category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	53/664	333/9376	2.24740403053656	ISG15/COL6A1/COL6A3/COL1A1/STAT1/EIF2AK2/LAMA2/MX1/HLA-A/PIK3R1/PDGFRB/CREB3L2/CDK6/AKT3/COL4A2/IRF9/CREB3L1/CHD4/MX2/TCF7L1/COL4A5/PTK2/COL6A2/PPP2R5E/FN1/TCF7L2/PTEN/HLA-B/CTNNB1/SOS1/STAT2/HLA-E/SOS2/PPP2R3A/PPP2R5C/PPP2R3C/PARD3/HLA-C/DLG1/ATP6V1E1/RB1/CREB5/MAML2/ITGB1/RAF1/ATP6V1D/HDAC1/HDAC2/ATR/NFKB1/ATP6V1G1/TNFRSF1A/TP53	6.39858198341988
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	41/664	227/9376	2.55039541425614	MT-CO3/MT-ND3/PIK3R1/FOS/AKT3/MAPK10/COX7A2L/MT-CO2/PRKD1/MAPK8/NDUFV2/PTK2/BRAF/PTEN/UQCR10/NDUFA4/SOS1/NDUFA7/NDUFB1/CBR1/ATP5MC2/NDUFS4/NDUFB8/NDUFC2/NDUFA10/SOS2/SOD1/NDUFS6/JUN/RAF1/PRKD3/NDUFA8/NDUFA11/PTPN11/NFKB1/NDUFA5/ATP5MC3/SDHD/SDHB/SDHA/COX7C	6.52798780544051
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	38/664	205/9376	2.61745518660006	COL3A1/MT-CO3/COL1A1/MT-ND3/PIK3R1/PRKCA/AKT3/MAPK10/COX7A2L/MT-CO2/PPP1CA/PPP1CB/MAPK8/NDUFV2/PTEN/UQCR10/NDUFA4/MMP2/NDUFA7/NDUFB1/SMAD3/ATP5MC2/NDUFS4/SMAD2/NDUFB8/NDUFC2/NDUFA10/NDUFS6/GFPT1/NDUFA8/NDUFA11/NFKB1/NDUFA5/ATP5MC3/SDHD/SDHB/SDHA/COX7C	6.4641523749754
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	41/664	235/9376	2.463573442707	MT-CO3/MT-ND3/ZNF516/CREB3L2/PRKG1/CREB3L1/SMARCA2/COX7A2L/MT-CO2/ARID1B/ATF2/NDUFV2/COA3/COX16/UQCR10/NDUFA4/SOS1/NDUFA7/NDUFB1/ATP5MC2/NDUFS4/NDUFB8/ADCY3/NDUFC2/NDUFA10/SOS2/NDUFS6/SMARCC2/CREB5/ADCY1/COA5/NDUFA8/NDUFA11/COA4/NDUFA5/ATP5MC3/SDHD/SDHB/SDHA/COX15/COX7C	6.27281300964291
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	45/664	275/9376	2.31062431544359	MT-CO3/MT-ND3/ITPR2/CACNA1D/PIK3R1/CREB3L2/CREB3L1/MAPK10/COX7A2L/MT-CO2/MAPK8/ATF2/NDUFV2/SEM1/PPP3CA/PSMB5/UQCR10/NDUFA4/NDUFA7/NDUFB1/ATP5MC2/NDUFS4/NDUFB8/HSPA1A/NDUFC2/NDUFA10/SOD1/PSMB4/NDUFS6/CSNK2B/EGR1/CREB5/NDUFA8/NDUFA11/PSMA3/PSMB1/NDUFA5/PSMA7/ATP5MC3/SDHD/FYN/SDHB/SDHA/PSMD1/COX7C	6.08990832813245
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	48/664	308/9376	2.20059458613675	MT-CO3/MT-ND3/CREB3L2/CREB3L1/MAPK10/COX7A2L/MT-CO2/TGM2/MAPK8/NDUFV2/SEM1/PSMB5/UQCR10/NDUFA4/NDUFA7/NDUFB1/ATP5MC2/RCOR1/NDUFS4/NDUFB8/NDUFC2/NDUFA10/SOD1/GRIA1/PSMB4/AP2A1/POLR2K/NDUFS6/POLR2A/CREB5/POLR2J3/NDUFA8/NDUFA11/HDAC1/HDAC2/PSMA3/PSMB1/NDUFA5/PSMA7/ATP5MC3/POLR2H/POLR2J/SDHD/SDHB/SDHA/PSMD1/COX7C/TP53	5.91461836835644
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	39/664	227/9376	2.4259858818534	B2M/ITPR2/HLA-A/PIK3R1/CREB3L2/PRKCA/CDK6/AKT3/PDGFRA/ROCK1/CREB3L1/GNG5/ATF2/GNAI1/PTK2/GNG11/IL1R1/PPP3CA/HLA-B/CTNNB1/CALM3/SOS1/TAP1/GNB2/ADCY3/CALM2/HLA-E/SOS2/HLA-C/RB1/CREB5/RAF1/TAP2/ADCY1/NFKB1/TAPBP/TNFRSF1A/GNA12/TP53	6.00415762448291
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	36/664	203/9376	2.50412487387976	COL6A1/IGF1/COL6A3/COL1A1/LAMA2/PIP5K1B/PIK3R1/PDGFRB/PRKCA/AKT3/PDGFRA/PAK3/COL4A2/ROCK1/MAPK10/PPP1CA/PPP1CB/MAPK8/COL4A5/PTK2/COL6A2/FN1/BRAF/PTEN/CTNNB1/EMP1/SOS1/PARVA/MYL9/RAP1A/SOS2/FLNA/JUN/ITGB1/RAF1/FYN	5.98118120600007
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	43/664	268/9376	2.26559971228196	MT-CO3/SNCAIP/MT-ND3/ITPR2/MAPK10/COX7A2L/MT-CO2/MAPK8/GNAI1/NDUFV2/UBB/SEM1/PRKN/PSMB5/CALM3/UQCR10/NDUFA4/NDUFA7/NDUFB1/ATP5MC2/NDUFS4/NDUFB8/NDUFC2/NDUFA10/CALM2/SOD1/MAOB/PSMB4/NDUFS6/TXN/NDUFA8/NDUFA11/PSMA3/PSMB1/NDUFA5/PSMA7/ATP5MC3/SDHD/SDHB/SDHA/PSMD1/COX7C/TP53	5.80313933170402
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	27/664	130/9376	2.93271547729379	COL3A1/COL1A1/PIK3R1/CREB3L2/FOS/PRKCA/AKT3/COL4A2/CREB3L1/GNG5/MAPK10/MAPK8/ATF2/GNAI1/COL4A5/GNG11/SOS1/MMP2/GNB2/SMAD2/ADCY3/SOS2/JUN/CREB5/RAF1/ADCY1/NFKB1	6.12594933507508
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	37/664	214/9376	2.44139173516496	B2M/BST2/ITPR2/HLA-A/PIK3R1/FOS/PRKCA/AKT3/PAK3/TAB2/GNG5/MAPK10/MAPK8/CUL5/GNAI1/PTK2/CUL4A/GNG11/PPP3CA/RBX1/HLA-B/CALM3/TAP1/GNB2/CALM2/HLA-E/AP1G1/HLA-C/JUN/RNF7/RAF1/TAP2/ATR/NFKB1/TAPBP/SKP1/TNFRSF1A	5.88849777083129
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	28/664	138/9376	2.86502531866597	MT-CO3/MT-ND3/PPA1/COX7A2L/MT-CO2/NDUFV2/UQCR10/NDUFA4/NDUFA7/NDUFB1/ATP5MC2/NDUFS4/NDUFB8/NDUFC2/NDUFA10/NDUFS6/ATP6V1E1/NDUFA8/ATP6V1D/NDUFA11/NDUFA5/ATP5MC3/ATP6V1G1/SDHD/SDHB/SDHA/COX15/COX7C	6.09320852043145
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	27/664	133/9376	2.86656400036235	ITPR2/CACNA1D/CREB3L2/FOS/PRKCA/AKT3/CREB3L1/GNG5/MAPK10/PPP1CA/PPP1CB/MAPK8/ATF2/GNAI1/PPP2R5E/GNG11/PPP3CA/CALM3/GNB2/CALM2/PPP2R3A/PPP2R5C/PPP2R3C/MAOB/GRIA1/CREB5/COMT	5.98512153907339
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	29/664	157/9376	2.6082418847364	MT-CO3/PIK3R1/FOS/AKT3/MAPK10/COX7A2L/MT-CO2/MAPK8/NDUFV2/UQCR10/NDUFA4/SREBF1/NDUFA7/NDUFB1/NDUFS4/NDUFB8/NDUFC2/NDUFA10/NDUFS6/JUN/NDUFA8/NDUFA11/NFKB1/NDUFA5/TNFRSF1A/SDHD/SDHB/SDHA/COX7C	5.61009262672525
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	33/664	196/9376	2.3774280796656	STAT1/EIF2AK2/ITPR2/HLA-A/PIK3R1/ZFP36/FOS/CDK6/AKT3/IRF9/GNG5/MAPK10/TCF7L1/MAPK8/UBB/GNG11/PPP3CA/TCF7L2/HLA-B/CTNNB1/CALM3/GNB2/STAT2/CALM2/HLA-E/FGF2/HLA-C/RB1/JUN/RAF1/NFKB1/TNFRSF1A/TP53	5.38005074116187
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	31/664	180/9376	2.43186077643909	B2M/STAT1/EIF2AK2/BST2/HLA-A/PIK3R1/SRSF7/AKT3/IRF9/TAB2/SP100/OAS1/PPP1CA/PPP1CB/OAS2/POU2F1/HLA-B/TAP1/STAT2/HLA-E/SRSF9/IFNGR2/IFIH1/HLA-C/TAP2/PTPN11/SRSF5/NFKB1/TAPBP/TNFRSF1A/TP53	5.35486230924372
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	22/664	106/9376	2.93066606046829	IGF1/PIK3R1/PDGFRB/CREB3L2/AKT3/PDGFRA/CREB3L1/TCF7L1/ZEB1/BRAF/TCF7L2/AR/PTEN/CTNNB1/SOS1/SOS2/RB1/CREB5/FOLR1/RAF1/NFKB1/TP53	5.5186261202893
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	17/664	69/9376	3.47895931552296	CACNA1D/CREB3L2/FOS/PRKCA/CREB3L1/PPP1CA/PPP1CB/ATF2/PPP3CA/CALM3/CALM2/MAOB/GRIA1/JUN/CREB5/HDAC1/HDAC2	5.70558043347674
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	30/664	174/9376	2.43456584960532	MAN1A1/SEC31A/TMEM258/MAPK10/SEC62/SEC61G/MAPK8/SEC24D/STT3B/SEC61B/VCP/PRKN/RBX1/HSPA1A/UBQLN1/UGGT2/ATXN3/SAR1A/PDIA6/DNAJC3/SEC23A/KRTCAP2/SSR4/TUSC3/SKP1/LMAN1/HERPUD1/DNAJA2/TXNDC5/SEC13	5.2730846384421
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	38/664	250/9376	2.14631325301205	HLA-A/PIP5K1B/PDGFRA/ARF1/CHMP5/RAB4A/EPS15/SNX3/VPS35/HLA-B/ASAP1/SMAD3/NEDD4/WASHC4/RAB31/SMAD2/VPS29/SH3KBP1/HSPA1A/HLA-E/SNX2/SNF8/PARD3/ARPC2/RAB7A/AP2A1/HLA-C/FOLR1/ASAP2/SNX4/EPN2/IGF2R/MVB12B/ASAP3/SNX5/VPS37A/WIPF1/DNM1	5.07158641824937
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	51/664	388/9376	1.85604272761148	MT-CO3/EIF2AK2/APOE/MT-ND3/ITPR2/CACNA1D/PIK3R1/MME/AKT3/APP/MAPK10/COX7A2L/MT-CO2/LRP1/MAPK8/NDUFV2/SEM1/PPP3CA/BRAF/PSMB5/CTNNB1/CALM3/UQCR10/NDUFA4/NDUFA7/NDUFB1/ATP5MC2/NDUFS4/NDUFB8/NDUFC2/NDUFA10/CALM2/PSMB4/NDUFS6/CSNK2B/DKK1/RAF1/NDUFA8/NDUFA11/PSMA3/PSMB1/NFKB1/NDUFA5/PSMA7/ATP5MC3/TNFRSF1A/SDHD/SDHB/SDHA/PSMD1/COX7C	4.75434307727729
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	32/664	204/9376	2.21497755728798	IGF1/COL1A1/ITPR2/PIK3R1/DCN/DDX5/PRKCA/AKT3/TWIST2/ROCK1/TIMP3/PPP1CA/PPP1CB/PTK2/FN1/ESR1/CTSL/BRAF/CTNNB1/SOS1/MMP2/HOXD10/LUM/SMAD2/CD63/SOS2/FGF2/FLNA/ITGB1/RAF1/PTPN11/TP53	4.84353074738161
Human Diseases	Cancer: specific types	hsa05214	Glioma	17/664	76/9376	3.15852885225111	IGF1/PIK3R1/PDGFRB/PRKCA/CDK6/AKT3/PDGFRA/BRAF/PTEN/CALM3/SOS1/CALM2/SOS2/POLK/RB1/RAF1/TP53	5.21595606336287
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	32/664	205/9376	2.20417278871584	ISG15/B2M/STAT1/EIF2AK2/HLA-A/PIK3R1/CDK6/AKT3/IRF9/TAB2/MAPK10/OAS1/MAPK8/OAS2/VIM/SEM1/HLA-B/TAP1/NEDD4/STAT2/HLA-E/POLK/HLA-C/RB1/JUN/TAP2/HDAC1/HDAC2/NFKB1/TAPBP/PSMD1/TP53	4.81247113153123
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	18/664	87/9376	2.92147901952638	PIK3R1/FOS/AKT3/MAPK10/TCF7L1/MAPK8/BRAF/TCF7L2/CTNNB1/SOS1/SMAD3/SMAD2/SOS2/POLK/RALA/JUN/RAF1/TP53	4.97074559339259
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	24/664	139/9376	2.43806882205079	ITPR2/PIK3R1/CREB3L2/FOS/AKT3/PGR/GREB1/CREB3L1/NCOA1/ATF2/GNAI1/ESR1/CALM3/KRT10/SOS1/MMP2/ADCY3/HSPA1A/CALM2/SOS2/JUN/CREB5/RAF1/ADCY1	4.71554988475761
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	22/664	122/9376	2.54631641319376	IGF1/STAT1/ITPR2/CACNA1D/PIK3R1/CREB3L2/FOS/PRKCA/AKT3/CREB3L1/JUNB/MAPK10/MAPK8/ATF2/GNAI1/PTK2/SOS1/ADCY3/SOS2/CREB5/RAF1/ADCY1	4.74596223342202
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	25/664	149/9376	2.36920837713269	MT-ND3/ITPR2/CACNA1D/PRKCA/GNG5/MAPK10/MAPK8/GNAI1/NDUFV2/GNG11/NDUFA4/NDUFA7/NDUFB1/GNB2/NDUFS4/NDUFB8/ADCY3/NDUFC2/NDUFA10/GRIA1/NDUFS6/ADCY1/NDUFA8/NDUFA11/NDUFA5	4.65096601394582
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	33/664	224/9376	2.0802495697074	B2M/HLA-A/PIK3R1/ZFP36/CREB3L2/FOS/IL15/AKT3/CREB3L1/MAPK10/MAPK8/ATF2/IL1R1/PPP3CA/PTEN/HLA-B/SMAD3/SMAD2/ADCY3/HLA-E/HLA-C/DLG1/RB1/JUN/EGR1/RANBP1/CREB5/ADCY1/ATR/NFKB1/CRTC3/TNFRSF1A/TP53	4.51752796787291
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	22/664	125/9376	2.48520481927711	PIK3R1/PRKCA/AKT3/ROCK1/MAPK10/MAPK8/GNAI1/PPP2R5E/PTEN/PPP2R3A/PPP2R5C/PPP2R3C/PRKCE/RAF1/NSMAF/ORMDL1/NFKB1/TNFRSF1A/CERS2/FYN/GNA12/TP53	4.61485181632012
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	57/664	480/9376	1.67680722891566	MT-CO3/SNCAIP/MT-ND3/ITPR2/CACNA1D/PRKCA/APP/MAPK10/COX7A2L/ATXN1/MT-CO2/FUS/MAPK8/NDUFV2/UBB/VCP/SEM1/PRKN/PPP3CA/BRAF/PSMB5/CTNNB1/CALM3/UQCR10/NDUFA4/NDUFA7/NDUFB1/ATP5MC2/NDUFS4/NDUFB8/NDUFC2/NDUFA10/CALM2/SOD1/ATXN3/GRIA1/PSMB4/NDUFS6/CSNK2B/DKK1/RAF1/NDUFA8/NDUFA11/PSMA3/PSMB1/NFKB1/NDUFA5/TANK/PSMA7/ATP5MC3/TNFRSF1A/WDR41/SDHD/SDHB/SDHA/PSMD1/COX7C	4.20241525967371
Human Diseases	Infectious disease: viral	hsa05162	Measles	23/664	136/9376	2.3880226789511	STAT1/EIF2AK2/MX1/PIK3R1/FOS/CDK6/AKT3/IRF9/TAB2/MAPK10/MX2/OAS1/MAPK8/OAS2/ADAR/HSPA1A/STAT2/IFIH1/JUN/CSNK2B/NFKB1/RAB9A/TP53	4.50132919421909
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	26/664	166/9376	2.21164174771375	EDNRA/ITPR2/CACNA1D/CREB3L2/AKT3/PRKG1/ROCK1/CREB3L1/PPP1CA/PPP1CB/PDE5A/ATF2/GNAI1/ATP2B4/PPP3CA/CALM3/MYL9/ADCY3/CALM2/SLC8A1/CREB5/PRKCE/RAF1/ADCY1/ATP2B1/GNA12	4.34819690104378
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	25/664	157/9376	2.24848438339345	ITPR2/HLA-A/CACNA1D/PIK3R1/CDK6/AKT3/ZFP36L1/PPP1CA/PPP1CB/PPP3CA/PTEN/HLA-B/CALM3/SMAD3/SMAD2/CALM2/HLA-E/ZFP36L2/HLA-C/RB1/RAF1/ATR/NFKB1/RBBP4/TP53	4.35513656268517
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	46/664	368/9376	1.76506024096386	MT-CO3/MT-ND3/SRSF7/COX7A2L/MT-CO2/FUS/NDUFV2/NUP153/VCP/SEM1/PRKN/PPP3CA/PSMB5/UQCR10/NDUFA4/NDUFA7/NDUFB1/HNRNPA3/ATP5MC2/NDUFS4/NDUFB8/NDUFC2/NDUFA10/UBQLN1/SOD1/GRIA1/PSMB4/NDUFS6/CHCHD10/NDUFA8/NDUFA11/PSMA3/PSMB1/NDUFA5/TANK/PSMA7/ATP5MC3/TNFRSF1A/WDR41/SDHD/SDHB/SDHA/PSMD1/COX7C/TP53/SEC13	4.13348244976382
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	33/664	238/9376	1.95788194795991	ISG15/STAT1/EIF2AK2/C1S/MX1/PIK3R1/CFD/FOS/PRKCA/IRF9/TAB2/MAPK10/MX2/OAS1/C1R/MAPK8/OAS2/RPS27L/RPS27/RPS29/ADAR/RPS17/STAT2/RSL24D1/MASP1/IFIH1/JUN/RPL39/RPLP1/RPL23/RPS23/NFKB1/TNFRSF1A	4.13224092809411
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	22/664	134/9376	2.31828807768387	EDNRA/CALCRL/ITPR2/CACNA1D/PRKCA/PRKG1/RAMP1/ROCK1/PPP1CA/PPP1CB/BRAF/CALD1/CALM3/RAMP2/MYL9/ADCY3/CALM2/PRKCE/RAF1/ADCY1/PPP1R14A/GNA12	4.24317052928833
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	18/664	99/9376	2.56736035049288	IGF1/PIK3R1/FOS/AKT3/MAPK10/MAPK8/PTK2/ESR1/BRAF/SOS1/MMP2/ADCY3/SOS2/RB1/JUN/RAF1/ADCY1/TP53	4.32806146456777
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	18/664	99/9376	2.56736035049288	DGKB/PIP5K1B/PIK3R1/PLPP3/PDGFRB/FOS/PRKCA/AKT3/PDGFRA/MAPK10/MAPK8/SOS1/SOS2/GPCPD1/JUN/RAF1/SLC22A3/PLPP1	4.32806146456777
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	13/664	59/9376	3.11129262813968	CTNNA3/PIK3R1/AKT3/TCF7L1/BRAF/TCF7L2/PTEN/CTNNB1/SOS1/SOS2/POLK/RAF1/TP53	4.49104217903031
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	18/664	101/9376	2.51652153167124	COL3A1/COL1A1/STAT1/PIK3R1/PRKCA/AKT3/COL4A2/MAPK10/MAPK8/COL4A5/FN1/MMP2/SMAD3/SMAD2/JUN/EGR1/PRKCE/NFKB1	4.23022096315434
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	24/664	156/9376	2.17238183503244	STAT1/EIF2AK2/MX1/PIK3R1/CDK6/AKT3/IFIT1/IRF9/MX2/OAS1/PIAS1/OAS2/CD81/BRAF/CTNNB1/SOS1/STAT2/SOS2/RB1/RAF1/YWHAE/NFKB1/TNFRSF1A/TP53	4.07639878984607
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	20/664	120/9376	2.35341365461847	PIK3R1/AKT3/MAPK10/KIDINS220/NTRK3/MAPK8/BRAF/CALM3/MAGED1/SOS1/RAP1A/CALM2/SOS2/JUN/RAF1/YWHAE/PTPN11/NFKB1/BEX3/TP53	4.11926989906409
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	15/664	77/9376	2.75074323267094	STAT1/PIK3R1/CDK6/AKT3/MAPK10/MAPK8/BRAF/SMAD3/SMAD2/POLK/RALA/RB1/RAF1/NFKB1/TP53	4.25853714321337
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	15/664	77/9376	2.75074323267094	PIK3R1/CDK6/AKT3/BRAF/SOS1/SMAD3/SOS2/POLK/RB1/RAF1/HDAC1/HDAC2/PTPN11/NFKB1/TP53	4.25853714321337
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	11/664	46/9376	3.37663698271346	PSMB9/SEM1/PSMB5/POMP/PSMB8/PSMB4/PSMA3/PSMB1/PSMA7/PSME1/PSMD1	4.46078908429828
Human Diseases	Cancer: specific types	hsa05218	Melanoma	14/664	73/9376	2.70803762997194	IGF1/PIK3R1/PDGFRB/CDK6/AKT3/PDGFRA/MITF/BRAF/PTEN/FGF2/POLK/RB1/RAF1/TP53	4.04443722090224
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	28/664	205/9376	1.92865119012636	EIF2AK2/HLA-A/PIK3R1/CREB3L2/CDK6/IRF9/CREB3L1/CHD4/SP100/HDAC8/ATF2/HNRNPK/HLA-B/HLA-E/GTF2H2/GSN/HLA-C/DLG1/RB1/JUN/RANBP1/CREB5/RASA2/YWHAE/HDAC1/HDAC2/NFKB1/TP53	3.71135030256845
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	16/664	93/9376	2.4293302241223	ITPR2/CACNA1D/PRKCA/MAPK10/MAPK8/CALM3/SOS1/MMP2/ADCY3/CALM2/SOS2/MMP14/JUN/EGR1/RAF1/ADCY1	3.82420020827174
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	19/664	122/9376	2.19909144775825	PIK3R1/FOS/AKT3/PAK3/MAPK10/MAPK8/PPP2R5E/PPP3CA/SOS1/SOS2/PPP2R3A/PPP2R5C/PPP2R3C/DLG1/JUN/RAF1/PTPN11/NFKB1/FYN	3.68025759600269
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	8/664	31/9376	3.64399533618344	SEC62/SEC61G/SEC61B/SRP14/SPCS2/SRP72/IMMP2L/IMMP1L	4.07063932005104
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	23/664	163/9376	1.99246064010644	STAT1/PIK3R1/CREB3L2/FOS/PRKCA/AKT3/TAB2/CREB3L1/MAPK10/MAPK8/ATF2/BRAF/SOS1/SMAD3/STAT2/SOS2/IFIH1/RB1/JUN/CREB5/RAF1/NFKB1/TP53	3.52872084764809
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	18/664	115/9376	2.21016238868518	ITPR2/CREB3L2/FOS/PRKCA/CREB3L1/MMP16/ATF2/GNAI1/BRAF/OXSR1/WNK1/ADCY3/MMP14/EGR1/CREB5/RAF1/ADCY1/GNA12	3.60474355244836
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	22/664	154/9376	2.01721170395869	CACNA1D/CREB3L2/PRKCA/AKT3/CREB3L1/CACNA2D1/PPP1CA/PPP1CB/ATF2/GNAI1/ATP2B4/PPP2R5E/CALM3/ADCY3/CALM2/SLC8A1/PPP2R3A/PPP2R5C/PPP2R3C/CREB5/ADCY1/ATP2B1	3.51374219944921
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	25/664	184/9376	1.9185437401781	PIK3R1/PRKCA/PAK3/SLIT3/EPHA6/ROCK1/GDF7/SEMA5A/ROBO1/GNAI1/PTK2/SRGAP2/PPP3CA/TRPC1/RASA1/MYL9/SEMA3C/SRGAP1/PARD3/ITGB1/RAF1/UNC5C/PTPN11/FYN/ABLIM1	3.47387742181863
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	16/664	98/9376	2.30538480452422	ITPR2/CACNA1D/CREB3L2/PRKCA/CREB3L1/PRKD1/ATF2/ATP2B4/CALM3/ADCY3/CALM2/CREB5/PRKCE/PRKD3/ADCY1/ATP2B1	3.58620532598034
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	17/664	109/9376	2.20227699789986	PIK3R1/CREB3L2/AKT3/CREB3L1/MAPK10/PPP1CA/PPP1CB/MAPK8/PTEN/OGT/SREBF1/CREB5/PRKCE/GFPT1/PTPN11/NFKB1/TNFRSF1A	3.48545074777969
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	21/664	148/9376	2.00358189514816	IGF1/PIK3R1/FOS/CDK6/AKT3/PGR/NCOA1/TCF7L1/ESR1/BRAF/TCF7L2/PTEN/CTNNB1/SOS1/SOS2/FGF2/POLK/RB1/JUN/RAF1/TP53	3.39735263147777
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	21/664	149/9376	1.99013503679146	DGKB/PIP5K1B/PIK3R1/PLPP3/PDGFRB/PRKCA/AKT3/PDGFRA/ARF1/SOS1/ADCY3/SOS2/RALA/RAF1/ADCY1/PTPN11/PLPP1/FYN/GNA12/DNM1/AGPAT4	3.3633188945117
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	15/664	93/9376	2.27749708511465	CTNNA3/SNAI2/ROCK1/TCF7L1/TCF7L2/HEG1/CTNNB1/NLK/MYL9/SMAD3/RAP1A/PARD3/CSNK2B/FER/FYN	3.41796775616492
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	16/664	103/9376	2.19347292080945	COL3A1/COL6A1/COL5A2/COL6A3/COL1A1/MME/COL14A1/COL18A1/COL4A2/ELN/COL15A1/COL4A5/SLC7A8/COL6A2/COL5A1/SLC8A1	3.36226389114231
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	20/664	142/9376	1.98880027150857	STAT1/ITPR2/PIK3R1/FOS/AKT3/MITF/IRF9/TAB2/JUNB/MAPK10/MAPK8/IL1R1/PPP3CA/STAT2/IFNGR2/JUN/CTSK/NFKB1/TNFRSF1A/FYN	3.27769515067589
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	20/664	142/9376	1.98880027150857	PIK3R1/FOS/AKT3/MAPK10/MAPK8/PTK2/IL1R1/CTSL/CTNNB1/CALM3/MMP2/SUMO2/CALM2/BMPR1A/JUN/TXN/NFKB1/TNFRSF1A/ACVR1/TP53	3.27769515067589
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	12/664	67/9376	2.52904153929149	ITPR2/PRKCA/PPP1CA/PPP1CB/PPP3CA/BRAF/CALM3/RAP1A/CALM2/GRIA1/RAF1/ADCY1	3.46749556846759
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	28/664	226/9376	1.74944023883143	EDNRA/CACNA1D/PIK3R1/CREB3L2/FOS/AKT3/ROCK1/CREB3L1/MAPK10/PPP1CA/PPP1CB/MAPK8/GNAI1/ATP2B4/BRAF/CALM3/MYL9/RAP1A/GLI3/ADCY3/CALM2/GRIA1/JUN/CREB5/RAF1/ADCY1/ATP2B1/NFKB1	3.1484110248764
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	23/664	178/9376	1.82455665358061	SFRP4/TLE4/DAAM1/PRKCA/INVS/MAPK10/MCC/PRICKLE1/TCF7L1/MAPK8/ROR1/PPP3CA/RBX1/TCF7L2/CTNNB1/NLK/SMAD3/APCDD1/JUN/CSNK2B/DKK1/SKP1/TP53	3.06615809257096
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	15/664	98/9376	2.16129825424146	MARCKS/PIP5K1B/PIK3R1/PLPP3/PRKCA/AKT3/ASAP1/MARCKSL1/GSN/ARPC2/PRKCE/RAF1/ASAP2/PLPP1/ASAP3	3.19036499427484
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	13/664	80/9376	2.29457831325301	IGF1/PIK3R1/PDGFRB/PRKCA/AKT3/PDGFRA/BRAF/PTEN/SOS1/NF1/SOS2/FGF2/RAF1	3.21022895753798
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	12/664	71/9376	2.38656032581028	STAT1/PIK3R1/FOS/PRLR/AKT3/MAPK10/MAPK8/ESR1/SOS1/SOS2/RAF1/NFKB1	3.23757993277273
NA	NA	hsa04517	IgSF CAM signaling	34/664	299/9376	1.60567353024137	PIK3R1/PRKCA/AKT3/PAK3/MAGI2/APP/SLIT3/TRIO/MAPK10/NTRK3/MAPK8/ROBO1/PTK2/KIRREL1/SRGAP2/ERC1/CTNNB1/RASA1/MYL9/CASK/RAP1A/PMP22/SRGAP1/PARD3/ARPC2/SPTBN1/EPB41L2/ITGB1/PTPRD/UNC5C/PTPN11/CLMP/FYN/PPFIA1	2.93841928097951
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	34/664	300/9376	1.60032128514056	IGF1/CACNA1D/PDGFRB/FOS/PRKCA/AKT3/PDGFRA/STMN1/TAB2/CACNA2D1/STK3/MAPK10/MAPK8/ATF2/IL1R1/PPP3CA/BRAF/NLK/SOS1/RASA1/RAP1A/HSPA1A/NF1/SOS2/FGF2/FLNA/JUN/RAF1/RASA2/MAP4K4/NFKB1/TNFRSF1A/GNA12/TP53	2.91747988450015
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	14/664	93/9376	2.12566394610701	LAMA2/PIK3R1/CDK6/AKT3/COL4A2/COL4A5/PTK2/FN1/PTEN/POLK/RB1/ITGB1/NFKB1/TP53	3.01173530405811
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	9/664	48/9376	2.64759036144578	ECHS1/BCAT1/HADHB/AUH/HIBADH/HIBCH/DLD/ALDH7A1/ACADM	3.15926704375355
NA	NA	hsa04518	Integrin signaling	20/664	154/9376	1.83382882178063	COL6A1/IGF1/COL6A3/COL1A1/LAMA2/PIK3R1/FBN1/PDGFRB/AKT3/PDGFRA/COL4A2/COL4A5/PTK2/COL6A2/FN1/CTNNB1/PARVA/FLNA/ITGB1/ITGAE	2.88028490707043
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	23/664	187/9376	1.73674376650989	STAT1/ITPR2/ANTXR2/IRF9/TAB2/MAPK10/OAS1/ANTXR1/MAPK8/NEK7/TXNIP/OAS2/GABARAP/IFI16/STAT2/GABARAPL2/CTSB/JUN/TXN/TP53BP1/YWHAE/NFKB1/TANK	2.80940203096937
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	15/664	105/9376	2.01721170395869	MITF/MAPK10/MAPK8/UBB/VCP/PRKN/TOMM20/GABARAP/MTX2/GABARAPL2/RAB7A/JUN/CSNK2B/USP15/TP53	2.89369965158454
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	15/664	105/9376	2.01721170395869	STAT1/ITPR2/PIK3R1/AKT3/IRF9/MAPK10/MAPK8/PPP3CA/CALM3/STAT2/CALM2/JUN/RAF1/PTPN11/NFKB1	2.89369965158454
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	16/664	115/9376	1.96458878994238	ITPR2/CACNA1D/PIK3R1/CREB3L2/FOS/PRKCA/AKT3/CREB3L1/GNG5/GNAI1/GNG11/GNB2/ADCY3/CREB5/ADCY1/FYN	2.87324680870852
Organismal Systems	Immune system	hsa04611	Platelet activation	17/664	126/9376	1.9051443870721	COL3A1/COL1A1/ITPR2/PIK3R1/AKT3/PRKG1/STIM1/ROCK1/PPP1CA/PPP1CB/GNAI1/RAP1A/ADCY3/ITGB1/ADCY1/SNAP23/FYN	2.82385903554031
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	14/664	97/9376	2.03800770090672	CACNA1D/FOS/PRKCA/PRKG1/GNG5/GNAI1/GNG11/CALM3/GNB2/RASD1/ADCY3/CALM2/GRIA1/ADCY1	2.83691680421174
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	12/664	78/9376	2.17238183503244	C1S/FOS/SERPING1/MAPK10/C1R/MAPK8/GNAI1/CALM3/CALM2/JUN/ITGB1/NFKB1	2.87033347377365
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	9/664	51/9376	2.49184975194897	PRKCA/ARF1/SLC12A2/SEC61G/SEC61B/ADCY3/ATP6V1E1/ATP6V1D/ATP6V1G1	2.94914753150785
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	38/664	362/9376	1.4822605338481	COL6A1/IGF1/COL6A3/COL1A1/LAMA2/PIK3R1/PDGFRB/CREB3L2/PRLR/PRKCA/CDK6/AKT3/PDGFRA/MAGI2/COL4A2/CREB3L1/GNG5/ATF2/COL4A5/PTK2/COL6A2/PPP2R5E/GNG11/FN1/PTEN/SOS1/GNB2/SOS2/FGF2/PPP2R3A/PPP2R5C/PPP2R3C/CREB5/ITGB1/RAF1/YWHAE/NFKB1/TP53	2.58337811098404
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	16/664	119/9376	1.89855219196112	PIK3R1/CREB3L2/FOS/IL15/AKT3/TAB2/CREB3L1/JUNB/MAPK10/MAPK8/ATF2/MMP14/JUN/CREB5/NFKB1/TNFRSF1A	2.723280656692
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	14/664	99/9376	1.99683582816113	IGF1/ITPR2/PIK3R1/PRKCA/MAPK10/PPP1CA/PPP1CB/MAPK8/IL1R1/CALM3/ADCY3/CALM2/PRKCE/ADCY1	2.75263230501394
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	11/664	70/9376	2.21893287435456	PIK3R1/AKT3/PAK3/BRAF/RBX1/SOS1/RAP1A/SOS2/JUN/RAF1/PTPN11	2.82590807521105
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	13/664	90/9376	2.03962516733601	IGF1/PIK3R1/CREB3L2/AKT3/CREB3L1/ATF2/SESN3/ADCY3/CREB5/ADCY1/SESN1/NFKB1/TP53	2.73586361689308
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	15/664	110/9376	1.92552026286966	DCN/FBN1/ROCK1/GDF7/SMAD5/THSD4/RBX1/SMAD3/SMAD2/BMPR1A/HDAC1/HDAC2/EMP3/SKP1/ACVR1	2.69554676358836
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	12/664	82/9376	2.0664119894211	B2M/HLA-A/CTSL/HLA-B/TAP1/HSPA1A/HLA-E/CTSB/HLA-C/TAP2/PSME1/TAPBP	2.67757322000499
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	11/664	73/9376	2.12774385212081	PIK3R1/PRKCA/CDK6/AKT3/BRAF/SOS1/SOS2/POLK/RB1/RAF1/TP53	2.67036810613827
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	19/664	155/9376	1.73089778468714	ITPR2/CACNA1D/CREB3L2/CDK6/CREB3L1/TCF7L1/ATF2/GNAI1/PBX1/BRAF/TCF7L2/CTNNB1/PDE8A/RASD1/RAP1A/ADCY3/RB1/CREB5/ADCY1	2.53305271628797
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	14/664	103/9376	1.91928880570827	COL3A1/COL1A1/LAMA2/PIK3R1/PRKCA/COL4A2/COL4A5/PTK2/FN1/IL1R1/RAB7A/ADCY1/NFKB1/SERPINB6	2.58982965015068
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	7/664	37/9376	2.67144252686421	CCDC6/TCF7L1/BRAF/TCF7L2/CTNNB1/POLK/TP53	2.8122431438752
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	24/664	212/9376	1.59854512389179	IGF1/PIK3R1/PDGFRB/PRKCA/AKT3/PDGFRA/MAGI2/PRKD1/GNAI1/EVL/BRAF/CTNNB1/CALM3/MAGI3/RAP1A/ADCY3/CALM2/FGF2/PARD3/RALA/ITGB1/RAF1/PRKD3/ADCY1	2.43350942072131
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	10/664	65/9376	2.17238183503244	ITPR2/CACNA1D/CREB3L2/CREB3L1/ATF2/PBX1/PDE8A/ADCY3/CREB5/ADCY1	2.61841415655751
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	20/664	170/9376	1.66123316796598	PIK3R1/PRKCA/CDK6/AKT3/SMARCA2/ARID1B/TCF7L1/BRAF/TCF7L2/PTEN/CTNNB1/SOS1/SMAD3/SMAD2/SOS2/POLK/RB1/SMARCC2/RAF1/TP53	2.40189683517311
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	12/664	86/9376	1.97029980386663	PIK3R1/PRKCA/AKT3/PAK3/MAPK10/MAPK8/PTK2/BRAF/SOS1/SOS2/JUN/RAF1	2.49550277264845
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	27/664	250/9376	1.52501204819277	MITF/OSBPL5/LAPTM4A/AP3S1/VPS35/CTSL/PSAP/OSBPL1A/CD63/VPS29/SCARB2/DMXL1/SUMF1/CTSB/RAB7A/AP1G1/AP2A1/ATP6V1E1/ATP6V1D/CTSK/IGF2R/LAMTOR2/ATP6V1G1/IDS/CD164/CTBS/HGSNAT	2.32278913816567
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	13/664	98/9376	1.87312515367593	DGKB/ITPR2/PIP5K1B/PIK3R1/PRKCA/IP6K2/INPP4B/PTEN/CALM3/INPP5A/CALM2/SACM1L/PI4KB	2.39868433086385
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	10/664	68/9376	2.07654145995748	PIK3R1/AKT3/TCF7L1/BRAF/TCF7L2/SOS1/ZBTB16/SOS2/RAF1/NFKB1	2.45961862877071
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	8/664	49/9376	2.30538480452422	CREB3L2/CREB3L1/ATF2/GNAI1/MAOB/JUN/CREB5/NFKB1	2.52916025903596
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	12/664	89/9376	1.90388520373629	ITPR2/PDGFRB/PRKCA/PDGFRA/PRKG1/GJA1/GNAI1/SOS1/ADCY3/SOS2/RAF1/ADCY1	2.36527315249517
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	12/664	89/9376	1.90388520373629	PLCL1/CACNA1D/PRKCA/GNG5/GNAI1/GNG11/GABARAP/GNB2/ADCY3/GABARAPL2/ADCY1/GLUL	2.36527315249517
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	25/664	232/9376	1.52160365600332	PIP5K1B/PIK3R1/PDGFRB/AKT3/PDGFRA/PAK3/ROCK1/ABI2/PPP1CA/PPP1CB/PTK2/FN1/BRAF/TMSB4X/SOS1/MYL9/SOS2/FGF2/GSN/ARPC2/ITGB1/RAF1/ARHGEF7/ITGAE/GNA12	2.2208910556242
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	25/664	233/9376	1.51507316820932	COL3A1/COL6A1/COL5A2/COL6A3/COL1A1/NID1/LAMA2/CSRP2/DCN/FBN1/DAAM1/COL4A2/ELN/FBLN1/COL4A5/COL6A2/FBLN2/SNTB2/FN1/VIM/COL5A1/MYL9/SYNPO2/SPTBN1/ITGB1	2.19792703937729
Organismal Systems	Nervous system	hsa04730	Long-term depression	9/664	60/9376	2.11807228915663	IGF1/ITPR2/PRKCA/PRKG1/GNAI1/BRAF/GRIA1/RAF1/GNA12	2.39850989022467
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	12/664	90/9376	1.88273092369478	STAT1/PIK3R1/FOS/AKT3/PPP3CA/PTEN/IFNGR2/JUN/CSNK2B/RAF1/PTPN11/NFKB1	2.3229828341222
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	13/664	101/9376	1.81748777287367	CREB3L2/PRKCA/MITF/CREB3L1/TCF7L1/GNAI1/TCF7L2/CTNNB1/CALM3/ADCY3/CALM2/RAF1/ADCY1	2.28031969326648
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	18/664	155/9376	1.63979790128255	HLA-A/SEC61G/C1R/SEC61B/CTSL/DYNC2H1/MRC2/HLA-B/STX7/TAP1/HLA-E/RAB7A/HLA-C/ATP6V1E1/ITGB1/TAP2/ATP6V1D/ATP6V1G1	2.21733031030163
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	17/664	144/9376	1.66700133868809	ITPR2/PIK3R1/PRKCA/AKT3/MAPK10/ATXN1/MAPK8/SEM1/PSMB5/ATXN10/ATXN3/GRIA1/PSMB4/PSMA3/PSMB1/PSMA7/PSMD1	2.22674660174924
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	10/664	71/9376	1.98880027150857	PIK3R1/PDGFRB/IDH1/AKT3/PDGFRA/NTRK3/PTEN/RAF1/LDHB/TP53	2.30882122974748
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	26/664	248/9376	1.48037310532452	FOS/AKT3/PAK3/TAB2/ARF1/MAPK10/TCF7L1/MAPK8/DYNC2LI1/DYNLT1/DYNC2H1/TCF7L2/CTNNB1/MYL9/FLNA/ARPC2/RAB7A/RALA/JUN/TXN/DYNLRB1/RAF1/NFKB1/SKP1/TNFRSF1A/RAB9A	2.116544743113
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	9/664	62/9376	2.04974737660319	IGF1/PIK3R1/AKT3/ADCY3/HSPA1A/SOD1/ADCY1/HDAC1/HDAC2	2.28940839206553
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	25/664	238/9376	1.48324389996963	IGF1/PIK3R1/PDGFRB/PRKCA/AKT3/PDGFRA/PAK3/GNG5/MAPK10/MAPK8/GNG11/CALM3/SOS1/RASA1/GNB2/RAP1A/NF1/CALM2/SOS2/FGF2/RALA/RAF1/RASA2/PTPN11/NFKB1	2.08468300917379
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	9/664	63/9376	2.01721170395869	ECHS1/ASH1L/SETD2/TMLHE/DLD/AASS/ALDH7A1/PRDM6/PHYKPL	2.23639012669575
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	9/664	63/9376	2.01721170395869	CUL4A/RBX1/GTF2H2/POLR2K/POLR2A/POLR2J3/POLR2H/POLR2J/GTF2H5	2.23639012669575
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	16/664	137/9376	1.64910737841878	ITPR2/PIK3R1/FOS/AKT3/MAPK10/PTPN13/MAPK8/CTSL/CTSB/JUN/RAF1/CTSK/NFKB1/ENDOG/TNFRSF1A/TP53	2.11288125578197
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	16/664	138/9376	1.63715732495198	IGF1/ITPR2/PGR/PPP1CA/PPP1CB/PPP2R5E/PPP3CA/RBX1/AR/CALM3/ADCY3/CALM2/PPP2R5C/ADCY1/YWHAE/SKP1	2.08165133330722
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	16/664	138/9376	1.63715732495198	PIP5K1B/PIK3R1/FOS/AKT3/ROCK1/TAB2/MAPK10/MAPK8/PTK2/FN1/ARPC2/JUN/ITGB1/NFKB1/ARHGEF7/WIPF1	2.08165133330722
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	14/664	117/9376	1.68963031613634	SMARCA2/CHD4/ARID1B/MORF4L1/RSF1/EPC1/CDK2AP1/SMARCA1/ZNHIT1/SMARCC2/HDAC1/HDAC2/RBBP4/DPF2	2.0722301020447
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	19/664	173/9376	1.55080437356362	STAT1/EIF2AK2/MX1/PIK3R1/PRKCA/CDK6/AKT3/IRF9/MX2/OAS1/OAS2/ADAR/STAT2/IFNGR2/IFIH1/RAF1/DNAJC3/NFKB1/TNFRSF1A	2.01867528122108
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	10/664	75/9376	1.88273092369478	IGF1/CDK6/PTEN/SESN3/SHISA5/PPM1D/TP53I3/SESN1/ATR/TP53	2.11887284414399
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	16/664	140/9376	1.61376936316695	ITPR2/AKT3/GNG5/GNAI1/GNG11/CALM3/SMAD3/GNB2/SMAD2/ADCY3/CALM2/SLC8A1/EGR1/PRKCE/RAF1/ADCY1	2.01993784774303
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	11/664	86/9376	1.80610815354441	CTNNA3/LAMA2/CACNA1D/GJA1/CACNA2D1/TCF7L1/SNTB2/TCF7L2/CTNNB1/SLC8A1/ITGB1	2.07322017814311
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	17/664	154/9376	1.55875449851353	ITPR2/CACNA1D/FOS/PRKCA/ROCK1/CACNA2D1/PPP1CA/PPP1CB/GNAI1/PPP3CA/CALM3/MYL9/ADCY3/CALM2/JUN/RAF1/ADCY1	1.93009896850225
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	21/664	201/9376	1.47527423125337	IGF1/HOXA10/DDX5/MITF/MLLT3/FUS/JMJD1C/CDK14/MAF/PTK2/ZEB1/PBX1/ZBTB16/POLK/MEIS1/CCNT2/HDAC1/HDAC2/NFKB1/PBX3/TP53	1.8803989707975
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	15/664	133/9376	1.59253555575686	IGF1/PIK3R1/AKT3/MAPK10/MAPK8/PRMT1/BRAF/PTEN/NLK/SOS1/GABARAP/SMAD3/SOS2/GABARAPL2/RAF1	1.89996020320694
Human Diseases	Substance dependence	hsa05034	Alcoholism	20/664	191/9376	1.47858449504826	CREB3L2/CREB3L1/GNG5/PPP1CA/PPP1CB/HDAC8/ATF2/GNAI1/GNG11/BRAF/CALM3/SOS1/GNB2/CALM2/SOS2/MAOB/CREB5/RAF1/HDAC1/HDAC2	1.84478803099859
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	17/664	157/9376	1.52896938070754	CTNNA3/SNAI2/GDF7/STK3/PPP1CA/TCF7L1/PPP1CB/FRMD6/WWTR1/TCF7L2/CTNNB1/SMAD3/SMAD2/BMPR1A/PARD3/DLG1/YWHAE	1.84522443460501
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	9/664	69/9376	1.84180199057098	PIK3R1/PRKCA/AKT3/MAPK10/MAPK8/SOS1/SOS2/RAF1/FYN	1.93749406704173
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	17/664	158/9376	1.51929235931066	CDK6/TFDP2/PDS5B/HDAC8/PPP2R5E/RBX1/SMAD3/SMAD2/CDKN1C/PPP2R5C/RB1/YWHAE/HDAC1/HDAC2/ATR/SKP1/TP53	1.81732612013029
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	17/664	158/9376	1.51929235931066	IGF1/PIK3R1/PRKCA/AKT3/RICTOR/BRAF/PTEN/SOS1/SOS2/ATP6V1E1/RAF1/ATP6V1D/GRB10/LAMTOR2/ATP6V1G1/TNFRSF1A/SEC13	1.81732612013029
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	20/664	193/9376	1.46326237592858	STAT1/PIK3R1/AKT3/ROCK1/GNG5/GNAI1/PTK2/GNG11/BRAF/SOS1/GNB2/RAP1A/ADCY3/STAT2/SOS2/PARD3/CXCL13/RAF1/ADCY1/NFKB1	1.79524669989759
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	22/664	217/9376	1.43156959635778	CACNA1D/PIK3R1/CREB3L2/FOS/PRKCA/AKT3/PGR/CREB3L1/ATF2/GNAI1/ESR1/AR/SOS1/ADCY3/SOS2/FGF2/RB1/JUN/CREB5/RAF1/ADCY1/NFKB1	1.7756911222864
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	5/664	30/9376	2.35341365461847	IDH1/DLD/SDHD/SDHB/SDHA	2.04969403530323
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	12/664	103/9376	1.64510469060709	FUS/PPP1CA/PPP1CB/PPP2R5E/FIP1L1/SAP18/RBM8A/PPP2R3A/PPP2R5C/PPP2R3C/CPSF7/UPF3A	1.81739540915906
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	12/664	103/9376	1.64510469060709	PIK3R1/FOS/AKT3/MAPK10/MAPK8/GNAI1/SMAD2/IFNGR2/JUN/ADCY1/NFKB1/TNFRSF1A	1.81739540915906
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	15/664	138/9376	1.53483499214248	PIK3R1/AKT3/MAPK10/PPP1CA/PPP1CB/MAPK8/BRAF/CALM3/INPP5A/SOS1/SREBF1/CALM2/SOS2/RAF1/RHOQ	1.74735490104686
Organismal Systems	Digestive system	hsa04970	Salivary secretion	11/664	93/9376	1.67016452908408	ITPR2/PRKCA/PRKG1/SLC12A2/ATP2B4/CALM3/CST3/ADCY3/CALM2/ADCY1/ATP2B1	1.79303794773767
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	16/664	150/9376	1.50618473895582	CTNNA3/PIK3R1/AKT3/TCF7L1/BRAF/TCF7L2/CTNNB1/SOS1/SMAD3/SMAD2/SOS2/FGF2/POLK/RB1/RAF1/TP53	1.72527645819894
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	13/664	116/9376	1.58246780224346	CTNNA3/PIK3R1/PRKCA/ROCK1/GNAI1/PTK2/CD99/CTNNB1/MMP2/MYL9/RAP1A/ITGB1/PTPN11	1.74263394370515
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	13/664	116/9376	1.58246780224346	ITPR2/CACNA1D/PRKCA/GNG5/GNAI1/GNG11/PPP3CA/TRPC1/GNB2/ADCY3/GRIA1/ADCY1/GLUL	1.74263394370515
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	10/664	83/9376	1.70126288285673	MBD5/RYBP/OGT/SCMH1/CSNK2B/HDAC1/HDAC2/DCAF7/RBBP4/SKP1	1.77154698365263
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	5/664	32/9376	2.20632530120482	ECHS1/ACSS3/HIBCH/DLD/LDHB	1.88705151188283
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	15/664	142/9376	1.49160020363143	UBE2K/PIAS1/CUL5/UBB/KLHL9/CUL4A/PRKN/RBX1/UBE2E1/UBE2E2/NEDD4/UBE2W/RNF7/KLHL13/SKP1	1.62956630367394
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	7/664	53/9376	1.86496931120709	PRKCA/ATP2B4/ESR1/SLC8A1/AP2A1/ATP2B1/DNM1	1.74329761631584
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	6/664	43/9376	1.97029980386663	ECHS1/ECI2/HADHB/ADH5/ALDH7A1/ACADM	1.76051724279876
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	10/664	86/9376	1.64191650322219	CACNA1D/CREB3L2/PRKCA/CREB3L1/ATF2/ADCY3/ABCC8/CREB5/ADCY1/PCLO	1.65093758363777
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	12/664	109/9376	1.55454846910578	STAT1/PIK3R1/FOS/AKT3/IRF9/TAB2/MAPK10/MAPK8/STAT2/JUN/CTSK/NFKB1	1.60765895022623
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	15/664	144/9376	1.47088353413655	AKT3/TAB2/MAPK10/TCF7L1/MAPK8/TCF7L2/CTNNB1/TRA2A/SREBF1/ADH5/NFKB1/TRA2B/ALDH7A1/TNFRSF1A/ACADM	1.5720182983749
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	21/664	216/9376	1.37282463186078	PIK3R1/MIB1/FOS/PRKCA/AKT3/TAB2/MAPK10/ABCA1/MAPK8/PTK2/PPP3CA/POU2F1/CALM3/RAP1A/HSPA1A/CALM2/JUN/NFKB1/TANK/TNFRSF1A/TP53	1.53036308405952
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	14/664	133/9376	1.4863665187064	HLA-A/PIK3R1/PRKCA/PPP3CA/BRAF/HLA-B/SOS1/HLA-E/SOS2/IFNGR2/HLA-C/RAF1/PTPN11/FYN	1.55953009188474
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	6/664	44/9376	1.92552026286966	CREB3L2/CREB3L1/DYNC2LI1/DYNC2H1/ADCY3/CREB5	1.6987741708679
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	5/664	34/9376	2.07654145995748	POLR2K/POLR2A/POLR2J3/POLR2H/POLR2J	1.73604521320362
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	17/664	169/9376	1.42040350752121	PIK3R1/AKT3/MAPK10/MAPK8/UVRAG/UBB/CTSL/PTEN/GABARAP/STX7/GABARAPL2/CTSB/RAB7A/RAF1/HMGB1/TANK/WDR41	1.52251421465566
Genetic Information Processing	Transcription	hsa03040	Spliceosome	23/664	243/9376	1.33650651990679	SRSF7/DDX5/PCBP1/SF3B6/FUS/SF1/LSM7/SNRPF/HNRNPK/TRA2A/HNRNPA3/HNRNPM/PRPF6/HSPA1A/RBM8A/SRSF9/SNRPB2/PRPF40A/SRSF5/SNRPE/TRA2B/PRPF40B/SF3B2	1.46723823458886
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	12/664	112/9376	1.51290877796902	STAT1/LAMA2/AKT3/TAB2/MAPK10/MAPK8/GNAI1/HSPA1A/IFNGR2/ITGB1/NFKB1/TNFRSF1A	1.50751143236041
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	9/664	78/9376	1.62928637627433	CTNNA3/PIK3R1/ARHGAP10/PTK2/FN1/CTNNB1/ARPC2/ITGB1/DNM1	1.5406770187291
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	10/664	91/9376	1.55170131073746	PIK3R1/FOS/AKT3/CD81/PPP3CA/SOS1/SOS2/JUN/RAF1/NFKB1	1.45997191805323
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	6/664	47/9376	1.80261471417585	CACNA1D/PIK3R1/MAPK10/MAPK8/ABCC8/PRKCE	1.52282235718158
Organismal Systems	Endocrine system	hsa04924	Renin secretion	8/664	69/9376	1.63715732495198	EDNRA/ITPR2/CACNA1D/GNAI1/PPP3CA/CALM3/CALM2/CTSB	1.46648327123735
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	12/664	115/9376	1.47344159245678	ITPR2/CACNA1D/PRKCA/APP/GNG5/GNAI1/GNG11/TRPC1/BRAF/GNB2/MAOB/RAF1	1.41025332122882
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	19/664	200/9376	1.34144578313253	FOS/PAK3/ROCK1/TAB2/ARF1/MAPK10/MAPK8/SEC24D/IL1R1/TMED10/ARPC2/JUN/ITGB1/PTPN11/NFKB1/TNFRSF1A/FYN/WIPF1/GNA12	1.34747523908691
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	10/664	93/9376	1.51833139007643	STAT1/FOS/MAPK10/MAPK8/MAF/PPP3CA/IFNGR2/JUN/MAML2/NFKB1	1.38680549563085
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	8/664	71/9376	1.59104021720686	MAPK10/MAPK8/ATP6V1E1/JUN/ATP6V1D/PTPN11/NFKB1/ATP6V1G1	1.38006252672224
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	11/664	107/9376	1.451638329017	ITPR2/CREB3L2/AKT3/CREB3L1/ATF2/PRMT1/PPP3CA/CALM3/CALM2/CREB5/LDHB	1.29711052768406
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	8/664	72/9376	1.56894243641232	ISG15/MAPK10/MAPK8/ADAR/IFIH1/NFKB1/TANK/SIKE1	1.33785938672742
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	5/664	39/9376	1.81031819586036	MTHFD2/AHCYL2/GCSH/DLD/ALDH7A1	1.3998933800509
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	14/664	144/9376	1.37282463186078	IGF1/PIK3R1/AKT3/SMAD5/TBX3/KAT6A/CTNNB1/SMAD3/SMAD2/BMPR1A/FGF2/RAF1/MEIS1/ACVR1	1.24465414668773
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	8/664	73/9376	1.54745007426968	BST2/MX1/MLLT3/MX2/MAP1B/NUP153/CCNT2/CPSF7	1.29629899137431
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	4/664	29/9376	1.94765267968425	STK3/FRMD6/WWTR1/FAT4	1.41098636540879
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	11/664	109/9376	1.42500276334697	STAT1/FOS/MAPK10/MAPK8/IL1R1/PPP3CA/SMAD3/SMAD2/IFNGR2/JUN/NFKB1	1.23210059071554
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	12/664	122/9376	1.38889986174205	STAT1/PIK3R1/PRKCA/AKT3/NCOA1/ESR1/CTNNB1/RAF1/MED13L/HDAC1/HDAC2/TP53	1.19361344202426
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	11/664	110/9376	1.41204819277108	IGF1/PIK3R1/AKT3/PGR/MAPK10/MAPK8/GNAI1/BRAF/ADCY3/RAF1/ADCY1	1.20007655912656
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	8/664	75/9376	1.50618473895582	ITPR2/CREB3L2/PRKCA/CREB3L1/ATF2/ADCY3/CREB5/ADCY1	1.21502608405782
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	6/664	52/9376	1.62928637627433	APOE/ABCA1/LRP1/OSBPL5/LRPAP1/LIPG	1.25620238467993
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	5/664	41/9376	1.72200999118425	BRAF/MMP2/RB1/RAF1/TP53	1.27905352552918
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	7/664	65/9376	1.52066728452271	DGKB/PLPP3/MBOAT2/PLPP1/ALDH7A1/AGPAT4/LIPG	1.16286567047748
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	7/664	65/9376	1.52066728452271	ITPR2/CACNA1D/PIK3R1/PRKCA/AKT3/TRPC1/RAF1	1.16286567047748
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	9/664	89/9376	1.42791390280222	COL6A1/COL6A3/COL1A1/LAMA2/COL4A2/COL4A5/COL6A2/FN1/ITGB1	1.11975863936457
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	3/664	21/9376	2.01721170395869	CHSY3/XYLT1/DSEL	1.28827875365732
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	7/664	66/9376	1.49762687112085	STAT1/MAF/SMAD3/SMAD2/IFNGR2/JUN/NFKB1	1.11998368267673
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	22/664	253/9376	1.22786799371399	ITPR2/PIK3R1/AKT3/ROCK1/TAB2/ARF1/MAPK10/MAPK8/UBB/PTK2/IL1R1/RBX1/MYL9/ARPC2/JUN/ITGB1/PRKCE/NFKB1/SKP1/TNFRSF1A/FNBP1/TP53	1.01434454092488
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	10/664	102/9376	1.38436097330498	ITPR2/PRKCA/SLC12A2/ATP2B4/TRPC1/SCTR/RAP1A/ADCY3/ADCY1/ATP2B1	1.07749823906464
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	8/664	78/9376	1.44825455668829	STAT1/FOS/TAB2/MARCKSL1/IFNGR2/JUN/ITGB1/NFKB1	1.09745820038091
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	11/664	116/9376	1.33901121728292	IDH1/ECHS1/ADH5/HIBCH/GLUD1/GCSH/PRPS2/DLD/SDHD/SDHB/SDHA	1.01425770189972
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	5/664	44/9376	1.60460021905805	MAN1A1/TMEM258/STT3B/KRTCAP2/TUSC3	1.10973176605808
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	6/664	56/9376	1.51290877796902	MAN1A1/TMEM258/STT3B/KRTCAP2/TUSC3/ST6GAL2	1.06276424176971
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	6/664	56/9376	1.51290877796902	ARF1/VCP/HSPA1A/SAR1A/NFKB1/CLK1	1.06276424176971
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	15/664	168/9376	1.26075731497418	STAT1/PIK3R1/PDGFRB/PRLR/IL15/AKT3/PDGFRA/IRF9/PIAS1/SOS1/STAT2/SOS2/IFNGR2/RAF1/PTPN11	0.941497628679265
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	5/664	45/9376	1.56894243641232	ABCA1/ABCC9/TAP1/ABCC8/TAP2	1.05613937651492
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	4/664	34/9376	1.66123316796598	RORB/RBX1/NFIL3/SKP1	1.06631348513428
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	3/664	23/9376	1.84180199057098	MME/PREP/ENPEP	1.11585854553212
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	7/664	70/9376	1.41204819277108	LAMA2/HLA-A/SNTB2/HLA-B/HLA-E/HLA-C/FYN	0.955270253043667
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	6/664	59/9376	1.43598121298754	PIK3R1/AKT3/PRKG1/GNAI1/ADCY3/ADCY1	0.927398689644039
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	11/664	122/9376	1.27315820659688	IGF1/PIK3R1/CREB3L2/AKT3/CREB3L1/PPP2R5E/SREBF1/PPP2R3A/PPP2R5C/PPP2R3C/CREB5	0.838378562884488
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	6/664	60/9376	1.41204819277108	PIK3R1/PRKCA/AKT3/PTK2/PPP3CA/RAF1	0.883933601785385
Organismal Systems	Digestive system	hsa04978	Mineral absorption	6/664	61/9376	1.38889986174205	CYBRD1/ATP2B4/ATOX1/SLC8A1/ATP2B1/HEPH	0.841244080239094
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	5/664	49/9376	1.44086550282764	GXYLT2/GALNT13/OGT/ST6GAL2/GALNT17	0.854169211612633
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	8/664	87/9376	1.2984351197895	MT-CO3/CACNA1D/CACNA2D1/COX7A2L/MT-CO2/UQCR10/SLC8A1/COX7C	0.772032919189984
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	5/664	50/9376	1.41204819277108	OAT/MAOB/P4HA2/SMS/ALDH7A1	0.80648455532601
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	6/664	63/9376	1.34480780263913	TCF7L1/TCF7L2/CTNNB1/GLI3/POLK/TP53	0.758076969060432
NA	NA	hsa04081	Hormone signaling	18/664	219/9376	1.16058755570226	IGF1/PIK3R1/PRLR/PRKG1/RAMP1/GNG5/SMAD5/GNAI1/GNG11/ESR1/RAMP2/GNB2/ADCY3/BMPR1A/ADCY1/HEPH/ACVR1/GNA12	0.66384713090409
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	7/664	76/9376	1.3005707038681	ITPR2/PRKCA/GNAI1/CALM3/ADCY3/CALM2/ADCY1	0.726311155709166
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	11/664	128/9376	1.21347891566265	ENPP1/PDE5A/DGUOK/PDE8A/ADCY3/ADCY1/PRPS2/NME7/NME3/ITPA/HPRT1	0.671346620398839
Human Diseases	Immune disease	hsa05330	Allograft rejection	4/664	39/9376	1.44825455668829	HLA-A/HLA-B/HLA-E/HLA-C	0.774397748552748
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	7/664	78/9376	1.26722273710226	PIP5K1B/IP6K2/INPP4B/PTEN/INPP5A/SACM1L/PI4KB	0.654239382032728
Human Diseases	Substance dependence	hsa05032	Morphine addiction	8/664	91/9376	1.24136104858996	PRKCA/GNG5/GNAI1/GNG11/PDE8A/GNB2/ADCY3/ADCY1	0.638715816321346
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	9/664	104/9376	1.22196478220575	DGKB/PLPP3/MBOAT2/ETNK1/GPCPD1/PLPP1/PEMT/LPGAT1/AGPAT4	0.628383504154427
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	14/664	170/9376	1.16286321757619	CACNA1D/ROCK1/MAPK10/MAPK8/MYL9/NEDD4/RAP1A/RAB8B/PARD3/ARPC2/DLG1/JUN/ITGB1/PRKCE	0.591592596701802
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	3/664	28/9376	1.51290877796902	CBR1/PCBD1/PTS	0.750361495002077
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	3/664	28/9376	1.51290877796902	ATP6V1E1/ATP6V1D/ATP6V1G1	0.750361495002077
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	9/664	105/9376	1.21032702237522	IGF1/LAMA2/CACNA1D/CACNA2D1/SNTB2/ADCY3/SLC8A1/ITGB1/ADCY1	0.598325037941846
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	4/664	41/9376	1.3776079929474	MAOB/GCSH/DLD/ALDH7A1	0.668939267523398
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	5/664	54/9376	1.3074520303436	BCAT1/ADI1/AHCYL2/SMS/LDHB	0.625504502962449
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/664	17/9376	1.66123316796598	GLUD1/GLUL	0.753312391845959
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	4/664	42/9376	1.34480780263913	ECHS1/MAOB/DLD/ALDH7A1	0.618270572817358
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	5/664	55/9376	1.28368017524644	PLPP3/PSAP/PLPP1/CERS2/ACER3	0.582491807826323
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	9/664	108/9376	1.17670682730924	NUP153/SAP18/SUMO2/RBM8A/TNPO1/XPO6/UPF3A/XPO4/SEC13	0.509897566259064
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	8/664	95/9376	1.18909321496512	FOS/IL15/CTSL/ATP6V1E1/JUN/ATP6V1D/CTSK/ATP6V1G1	0.511388675605208
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	6/664	70/9376	1.21032702237522	AKT3/MAPK10/MAPK8/PTPN11/NFKB1/TNFRSF1A	0.487610797501822
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	9/664	110/9376	1.1553121577218	IGF1/PIK3R1/PRKCA/AKT3/TIMP1/RBX1/IFNGR2/NFKB1/LDHB	0.452341456895655
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	3/664	31/9376	1.36649825106879	ECHS1/HIBCH/ALDH7A1	0.564252958813484
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	3/664	31/9376	1.36649825106879	GCSH/GLUL/DLD	0.564252958813484
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	4/664	44/9376	1.28368017524644	HLA-A/HLA-B/HLA-E/HLA-C	0.520689361248268
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/664	19/9376	1.4863665187064	IDS/HGSNAT	0.585845233583966
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	2/664	19/9376	1.4863665187064	GCSH/DLD	0.585845233583966
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	4/664	45/9376	1.25515394912985	HLA-A/HLA-B/HLA-E/HLA-C	0.473647447444104
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	7/664	85/9376	1.16286321757619	ENPP1/DUT/DGUOK/NME7/NME3/ITPA/HPRT1	0.416401214881581
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	3/664	32/9376	1.32379518072289	MAPK10/MAPK8/TNFRSF1A	0.506511953876165
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	3/664	33/9376	1.28368017524644	IDH1/BCAT1/DLD	0.450664684341493
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	3/664	33/9376	1.28368017524644	STX7/STX16/SNAP23	0.450664684341493
NA	NA	hsa04519	Cadherin signaling	30/664	404/9376	1.04855063819635	CTNNA3/LHFPL3/PDGFRB/DAAM1/PDGFRA/GJA1/ROCK1/STK3/MAPK10/ABI2/PPP1CA/PRICKLE1/TCF7L1/PPP1CB/MAPK8/EVL/PTK2/PCDH18/WWTR1/VIM/TCF7L2/CTNNB1/KRT10/CDH11/RERE/ARPC2/RAF1/YWHAE/FAT4/NFKB1	0.275392264812225
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	4/664	47/9376	1.2017431427839	ADH5/DLD/ALDH7A1/LDHB	0.382772658927469
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	7/664	88/9376	1.12322015334064	C1S/CFD/SERPING1/C1R/TFPI/MASP1/F10	0.320606794630372
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	24/664	323/9376	1.04919989555746	MARCKS/ZFPM2/PIK3R1/PDGFRB/PRKCA/CDK6/PDGFRA/STMN1/ROCK1/TIMP3/MMP16/ZEB1/VIM/PTEN/HNRNPK/SOS1/HOXD10/SOS2/PRKCE/RAF1/HDAC1/HDAC2/NFKB1/TP53	0.248416206975742
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	12/664	157/9376	1.07927250402885	ABCA1/LRP1/PTK2/PBX1/RAB7A/MEGF10/PTPN11/VPS8/MFGE8/TMEM30A/ATP8A2/ANO6	0.276529354554907
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/664	21/9376	1.34480780263913	ENPP1/BCAT1	0.43669234684041
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	5/664	62/9376	1.13874854255733	TLE4/ATXN1/MAML2/HDAC1/HDAC2	0.302598591620657
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/664	22/9376	1.28368017524644	MAOB/ALDH7A1	0.367749752133835
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	3/664	36/9376	1.17670682730924	GALNT13/ST6GALNAC3/GALNT17	0.293252610045071
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	6/664	79/9376	1.07244166539576	AP2A1/ATP6V1E1/ATP6V1D/ATP6V1G1/DNM1/STXBP1	0.178501265996135
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/664	23/9376	1.22786799371399	GLUD1/GLUL	0.302052562107326
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	3/664	37/9376	1.14490394008466	GLUD1/GFPT1/GLUL	0.243804441656822
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	3/664	37/9376	1.14490394008466	ADH5/MAOB/COMT	0.243804441656822
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	3/664	37/9376	1.14490394008466	PMM1/GFPT1/GALK2	0.243804441656822
Genetic Information Processing	Translation	hsa03010	Ribosome	16/664	222/9376	1.01769239118637	RPS27L/MRPS26/RPS27/RPS29/RPS17/RSL24D1/RPL39/RPLP1/RPL23/RPS23/MRPL20/MRPS18C/MRPL51/MRPS10/MRPL1/MRPL54	0.0736492470026993
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	3/664	38/9376	1.1147748890298	PMM1/GFPT1/GALK2	0.195714268778531
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/664	38/9376	1.1147748890298	IGF1/PIK3R1/PRKCA	0.195714268778531
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/664	10/9376	1.41204819277108	ETHE1	0.359899863110448
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	13/664	181/9376	1.01417826000133	STAT1/AKT3/MAPK10/MAPK8/PPP3CA/MRC2/CALM3/CALM2/IFNGR2/RAB7A/RAF1/NFKB1/TNFRSF1A	0.0531737269795584
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	12/664	168/9376	1.00860585197935	STAT1/EIF2AK2/IRF9/MAPK10/CHMP5/MAPK8/STAT2/IFNGR2/GLUD1/GLUL/HMGB1/TNFRSF1A	0.0310725289993155
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	4/664	54/9376	1.04596162427488	HLA-A/HLA-B/HLA-E/HLA-C	0.0935079300509901
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	6/664	83/9376	1.02075772971404	PCBP1/ADAR/IFI16/POLR2K/NFKB1/POLR2H	0.052438670805698
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	7/664	99/9376	0.998417914080565	IGF1/LAMA2/CACNA1D/CACNA2D1/SNTB2/SLC8A1/ITGB1	-0.00436872420524755
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	3/664	41/9376	1.03320599471055	SEM1/SSBP1/RAD51B	0.0588250095176219
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	4/664	57/9376	0.990911012470936	ECHS1/HADHB/FADS2/ACADM	-0.019001112268875
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/664	12/9376	1.17670682730924	VKORC1	0.169092363442415
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	3/664	43/9376	0.985149901933315	PLPP3/ABCA1/PLPP1	-0.0269440987202813
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/664	28/9376	1.00860585197935	ECHS1/HADHB	0.0125899579698335
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	4/664	59/9376	0.957320808658362	ENPP1/DUT/NME7/NME3	-0.0907851644663249
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/664	29/9376	0.973826339842127	CALM3/CALM2	-0.0389706887421103
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	17/664	254/9376	0.945071625083009	EDNRA/ITPR2/CACNA1D/PDGFRB/PRKCA/PDGFRA/STIM1/NTRK3/ATP2B4/PPP3CA/CALM3/ADCY3/CALM2/SLC8A1/FGF2/ADCY1/ATP2B1	-0.245007466361314
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/664	30/9376	0.941365461847389	FOLR1/NFKB1	-0.0887998009359856
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	5/664	78/9376	0.905159097930182	LSM7/DHX36/CNOT2/EXOSC7/DCP1A	-0.232198254663639
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	6/664	94/9376	0.901307357087926	FOS/TAB2/MAPK10/MAPK8/JUN/NFKB1	-0.265484193175852
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/664	15/9376	0.941365461847389	ST6GALNAC3	-0.0627406133608794
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	3/664	48/9376	0.882530120481928	CACNA1D/PIK3R1/AKT3	-0.225249387031789
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	2/664	32/9376	0.882530120481928	GABARAP/GABARAPL2	-0.183757825127167
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/664	16/9376	0.882530120481928	MAOB	-0.129825299986988
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	5/664	82/9376	0.861004995592125	DUT/NME7/NME3/ITPA/HPRT1	-0.348992045484255
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	4/664	67/9376	0.843013846430498	ADH5/DLD/ALDH7A1/LDHB	-0.356006542546419
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/664	52/9376	0.814643188137164	IGF1/ADCY3/ADCY1	-0.370015429949905
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	3/664	54/9376	0.784471218206158	REV3L/POLK/ATR	-0.438488642860469
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/664	38/9376	0.743183259353202	ENPP1/NNMT	-0.437924192570746
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	2/664	38/9376	0.743183259353202	TAP1/TAP2	-0.437924192570746
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	6/664	105/9376	0.806884681583477	TAB2/ERC1/IL1R1/CSNK2B/NFKB1/TNFRSF1A	-0.549362268879502
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/664	20/9376	0.706024096385542	LSS	-0.363322563459361
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	9/664	154/9376	0.825222969801283	MTHFD2/BCAT1/PMM1/VKORC1/NME7/DLD/NME3/PTS/COX15	-0.603730201012885
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	4/664	75/9376	0.753092369477912	IDH1/BCAT1/PRPS2/GLUL	-0.592667436114523
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	4/664	75/9376	0.753092369477912	PIK3R1/AKT3/REV3L/TP53	-0.592667436114523
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	4/664	76/9376	0.743183259353202	PLIN2/FADS2/DBI/ACADM	-0.620582316586946
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	2/664	42/9376	0.672403901319564	PCBP1/TP53	-0.587408480996192
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/664	23/9376	0.613933996856993	LARGE1	-0.511753421317469
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/664	23/9376	0.613933996856993	PDSS2	-0.511753421317469
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/664	23/9376	0.613933996856993	SSBP1	-0.511753421317469
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/664	23/9376	0.613933996856993	GLUD1	-0.511753421317469
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	2/664	44/9376	0.64184008762322	GTF2H2/GTF2H5	-0.657395448371365
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	2/664	44/9376	0.64184008762322	HMGB1/MPG	-0.657395448371365
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/664	24/9376	0.588353413654618	XYLT1	-0.557427813558841
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	3/664	63/9376	0.672403901319564	PTGDS/CBR3/CBR1	-0.720236188574886
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	5/664	99/9376	0.713155652914689	C1S/CFD/C1R/KRT10/MASP1	-0.792083303982159
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/664	46/9376	0.613933996856993	HEPH/COX15	-0.724620135580302
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	4/664	83/9376	0.680505153142691	IDH1/ECI2/SLC25A17/SOD1	-0.807115485617768
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/664	26/9376	0.543095458758109	FADS2	-0.644046297138618
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/664	27/9376	0.522980812137439	ECHS1	-0.685245031634123
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/664	27/9376	0.522980812137439	FADS2	-0.685245031634123
NA	NA	hsa03272	Virion - Hepatitis viruses	2/664	48/9376	0.588353413654618	CD81/CD63	-0.789335458829346
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3/664	68/9376	0.622962437987243	ALDH1A2/ALDH1A3/ADH5	-0.861433252472692
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	2/664	50/9376	0.564819277108434	LRP1/CD81	-0.85176088123905
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/664	51/9376	0.553744389321994	PLPP3/PLPP1	-0.88217572240987
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	8/664	160/9376	0.706024096385542	HLA-A/GLG1/CD99/HLA-B/HLA-E/HLA-C/ITGB1/PTPRD	-1.03540733378187
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/664	30/9376	0.470682730923695	PIGP	-0.80163107968239
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/664	31/9376	0.45549941702293	PRPS2	-0.838301585681539
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/664	31/9376	0.45549941702293	ALDH7A1	-0.838301585681539
NA	NA	hsa04981	Folate transport and metabolism	1/664	31/9376	0.45549941702293	FOLR1	-0.838301585681539
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	2/664	56/9376	0.504302925989673	GLI3/CSNK1G3	-1.02710101218012
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/664	35/9376	0.403442340791738	PMM1	-0.976113921130313
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3/664	79/9376	0.53622083269788	CBR3/ADH5/CBR1	-1.1427838945142
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	2/664	59/9376	0.478660404329181	IDH1/SMS	-1.10896901857669
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/664	36/9376	0.392235609103079	ENPP1	-1.00861124970047
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/664	36/9376	0.392235609103079	SSBP1	-1.00861124970047
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/664	37/9376	0.381634646694888	PRKCA	-1.04041490945237
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	9/664	195/9376	0.651714550509731	PIK3R1/PRKCA/AKT3/HDAC8/RAF1/HDAC1/HDAC2/HMGB1/NFKB1	-1.35680797492326
NA	NA	hsa04082	Neuroactive ligand signaling	9/664	199/9376	0.638614760549737	PRKCA/GNG5/GNAI1/GNG11/P2RY14/GNB2/ADCY3/GRIA1/ADCY1	-1.42251654723229
NA	NA	hsa04382	Cornified envelope formation	10/664	217/9376	0.650713452889901	S100A6/COL4A2/S100A4/COL4A5/PPP2R5E/KRT10/DST/PPP2R3A/PPP2R5C/PPP2R3C	-1.4371378940311
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/664	41/9376	0.34440199823685	GRIA1	-1.16140350649393
Organismal Systems	Digestive system	hsa04976	Bile secretion	3/664	90/9376	0.470682730923695	SCTR/ADCY3/ADCY1	-1.39294421081577
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/664	73/9376	0.38686251856742	ADH5/MAOB	-1.45183923815362
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/664	50/9376	0.282409638554217	IL15	-1.40450936009407
Cellular Processes	Cell motility	hsa04814	Motor proteins	7/664	194/9376	0.50950192522668	DYNC2LI1/DYNLT1/DYNC2H1/MYL9/DYNLRB1/KIFAP3/MYO9B	-1.9058129443003
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/664	66/9376	0.213946695874407	COMT	-1.76913049802127
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	4/664	143/9376	0.394978515460443	C1S/C1R/SSB/RO60	-2.01269580934914
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/664	70/9376	0.201721170395869	CBR1	-1.85068648020741
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	2/664	100/9376	0.282409638554217	CXCL13/TNFRSF1A	-1.99162225802845
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	2/664	100/9376	0.282409638554217	MME/IL1R1	-1.99162225802845
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	10/664	298/9376	0.473841675426538	PRLR/IL15/GDF7/IL1R1/BMPR1A/IFNGR2/GDF11/CXCL13/TNFRSF1A/ACVR1	-2.5482394407929
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	3/664	183/9376	0.231483310290342	NOP10/CSNK2B/NVL	-2.89841763031324
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	9/664	370/9376	0.343471182025399	EDNRA/CALCRL/PRLR/NPW/P2RY14/PGRMC1/NR3C1/SCTR/GRIA1	-3.55712747610168
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	5/664	449/9376	0.15724367402796	PRKG1/CALM3/ADCY3/CALM2/SLC8A1	-5.05223064469031