category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	98/943	238/9376	4.09406774374649	RPLP1/RPL29/RPS29/RPS27L/ISG15/RPL4/RPS28/RPL35/RPL15/RPS23/UBA52/C1QA/RPS14/RPL28/RPSA/RPL22/RPS12/RPL18A/RPS19/RPL14/RPL39/RPS27A/RPS7/NFKBIA/PRKCB/RPS2/RPLP0/RPL30/RPL27/FAU/RPL23A/RPL12/RPL8/RPL32/RPL36AL/RPS15A/RPL26/RPS26/RPS21/C1QB/RPL18/RPL19/RPS18/RPS6/RPS3A/RPL7A/RPL36A/RPS5/RPS25/RPL36/STAT1/RPS4X/RPS3/RPL10/C1QC/RPL34/RPL11/RPS27/IRF9/TNF/RPL3/RPS24/RPL35A/RPS17/RPLP2/RPL9/RPS9/RPL10A/RPL13/RPS13/CSF2/RPL24/RPL21/RPL37/RPL41/OAS2/RPL17/RPS16/RPS15/RPL26L1/MX1/RPL6/RPL37A/FOS/IL1B/RPL5/RPL7/MX2/OAS1/NFKB1/RPL22L1/CGAS/RPL38/CXCL8/CASP1/MAPK12/PIK3R1/RPL27A	16.1675105977135
Genetic Information Processing	Translation	hsa03010	Ribosome	92/943	222/9376	4.12041309602285	RPLP1/RPL29/RPS29/RPS27L/RPL4/RPS28/RPL35/RPL15/RPS23/UBA52/RPS14/RPL28/RPSA/RPL22/RPS12/RPL18A/RPS19/RPL14/RPL39/RPS27A/RPS7/RPS2/RPLP0/RPL30/RPL27/FAU/RPL23A/RPL12/RPL8/RPL32/RPL36AL/RPS15A/RPL26/RPS26/RPS21/RPL18/RPL19/RPS18/RPS6/RPS3A/RPL7A/RPL36A/RPS5/RPS25/RPL36/RPS4X/RPS3/RPL10/MRPL51/RPL34/RPL11/RPS27/RPL3/MRPL23/RPS24/MRPL41/RPL35A/RPS17/RPLP2/RPL9/RPS9/MRPL11/RPL10A/RPL13/RPS13/RPL24/MRPS6/RPL21/RPL37/RPL41/RPL17/RPS16/RPS15/MRPL40/RPL26L1/RACK1/RPL6/MRPS21/MRPS7/RPL37A/MRPL20/RPL5/RPL7/MRPL4/RPL22L1/MRPS26/RPL38/MRPL47/MRPL52/MRPS24/MRPL18/RPL27A	15.7337976148499
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	99/943	275/9376	3.5793849416755	RAC2/ATP5F1E/SLC25A5/PSMA2/CYBA/COX6C/PSMA7/UQCRQ/NDUFB2/C1QA/NDUFB1/COX5A/ATP5MC2/CCL5/CYCS/UQCRH/CSNK2B/NDUFA2/ATP5F1D/ATP5PF/TUBB/TUBA1B/PSMA4/ATP5MC3/UQCR11/C1QB/PSMB1/ATP5PO/PSMB3/SLC25A6/NDUFB10/ATP5F1B/NCF1/NDUFA12/UQCR10/HSPA8/NDUFAB1/COX5B/C1QC/COX6B1/TNF/SOD1/COX7B/COX6A1/COX7A2/BAX/UQCRB/COX7C/SEM1/ITPR2/NDUFS6/COX8A/NDUFA11/NDUFB11/NCAM1/PSMB4/NDUFB8/NDUFB4/PSMB2/VDAC2/NDUFB6/TUBA4A/ATP5F1C/FYN/PSMD8/HSPA6/NDUFA13/NDUFA1/PSMC5/SDHD/PSMB6/RAC1/VDAC3/PRNP/NDUFB3/PSMC4/CYC1/ATP5PD/ATP5MC1/IL1B/PRKACB/COX4I1/PSMA5/CREB3L2/NDUFA6/NDUFS5/NDUFV2/PSMD13/UQCRFS1/NDUFB5/PPIF/PSMC1/PSMA1/PSMD9/PSMA3/MAPK12/NDUFA4/PIK3R1/NDUFV1	14.5173846595425
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	93/943	268/9376	3.45027777338124	ATP5F1E/UBC/SLC25A5/PSMA2/CALM3/COX6C/CALM1/PSMA7/UQCRQ/UBA52/NDUFB2/NDUFB1/COX5A/ATP5MC2/RPS27A/CYCS/UQCRH/NDUFA2/ATP5F1D/ATP5PF/TUBB/TUBA1B/PSMA4/UBB/DUSP1/ATP5MC3/UQCR11/PSMB1/ATP5PO/PSMB3/SLC25A6/NDUFB10/ATP5F1B/NDUFA12/UQCR10/NDUFAB1/UBE2L6/COX5B/COX6B1/GNAS/SOD1/COX7B/COX6A1/COX7A2/BAX/UQCRB/PARK7/COX7C/SEM1/ITPR2/NDUFS6/COX8A/NDUFA11/NDUFB11/UBE2L3/GNAI2/PSMB4/NDUFB8/NDUFB4/PSMB2/VDAC2/NDUFB6/TXN/TUBA4A/ATP5F1C/PSMD8/NDUFA13/NDUFA1/PSMC5/SDHD/PSMB6/VDAC3/NDUFB3/PSMC4/CYC1/ATP5PD/ATP5MC1/PRKACB/COX4I1/PSMA5/NDUFA6/NDUFS5/NDUFV2/PSMD13/UQCRFS1/NDUFB5/PPIF/PSMC1/PSMA1/PSMD9/PSMA3/NDUFA4/NDUFV1	13.6088566987249
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	60/943	138/9376	4.32292867352114	ATP5F1E/COX6C/ATP5MG/UQCRQ/NDUFB2/ATP5ME/NDUFB1/COX5A/ATP5MC2/CYCS/UQCRH/NDUFA2/ATP5F1D/ATP5PF/ATP5MC3/UQCR11/ATP5PO/NDUFB10/ATP5F1B/COX17/NDUFA12/UQCR10/ATP6V1F/NDUFAB1/COX5B/ATP6V0B/ATP6V0C/PPA1/COX6B1/COX7B/COX6A1/COX7A2/UQCRB/COX7C/NDUFS6/COX8A/NDUFA11/NDUFB11/NDUFB8/ATP5MF/NDUFB4/NDUFB6/ATP5F1C/NDUFA13/NDUFA1/SDHD/TCIRG1/NDUFB3/ATP6V1G1/CYC1/ATP5PD/ATP5MC1/COX4I1/NDUFA6/NDUFS5/NDUFV2/UQCRFS1/NDUFB5/NDUFA4/NDUFV1	13.1498869113647
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	92/943	308/9376	2.96990814063985	ATP5F1E/SLC25A5/PSMA2/COX6C/PSMA7/UQCRQ/NDUFB2/NDUFB1/POLR2L/COX5A/ATP5MC2/CYCS/UQCRH/NDUFA2/ATP5F1D/ATP5PF/TUBB/POLR2J/TUBA1B/PSMA4/ATP5MC3/UQCR11/PSMB1/ATP5PO/PSMB3/SLC25A6/NDUFB10/ATP5F1B/NDUFA12/UQCR10/NDUFAB1/COX5B/COX6B1/POLR2K/SOD1/COX7B/COX6A1/COX7A2/BAX/UQCRB/COX7C/SEM1/NDUFS6/COX8A/NDUFA11/NDUFB11/PSMB4/NDUFB8/POLR2G/NDUFB4/PSMB2/VDAC2/DCTN3/NDUFB6/TUBA4A/ATP5F1C/PSMD8/NDUFA13/NDUFA1/PSMC5/AP2S1/SDHD/PSMB6/VDAC3/NDUFB3/DCTN6/PSMC4/CYC1/ATP5PD/ATP5MC1/COX4I1/PSMA5/HDAC1/POLR2F/CREB3L2/CLTB/NDUFA6/NDUFS5/NDUFV2/PSMD13/UQCRFS1/NDUFB5/PPIF/PSMC1/PSMA1/AP2M1/PSMD9/POLR2E/PSMA3/HDAC2/NDUFA4/NDUFV1	11.7548207749461
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	71/943	205/9376	3.44358171895611	RAC2/ATP5F1E/SLC25A5/GAPDH/CYBA/COX6C/CTSD/UQCRQ/NDUFB2/PPP1CA/COL1A2/NDUFB1/COX5A/TGFB1/ATP5MC2/UQCRH/PRKCB/NDUFA2/ATP5F1D/ATP5PF/ATP5MC3/UQCR11/ATP5PO/SLC25A6/NDUFB10/ATP5F1B/NCF1/NDUFA12/UQCR10/NDUFAB1/COX5B/ATP2A3/COX6B1/COX7B/COX6A1/COX7A2/UQCRB/COX7C/NDUFS6/COX8A/NDUFA11/NDUFB11/NDUFB8/NDUFB4/VDAC2/NDUFB6/ATP5F1C/PARP1/NDUFA13/NDUFA1/SDHD/RAC1/VDAC3/NDUFB3/CYC1/ATP5PD/ATP5MC1/COL1A1/COX4I1/NFKB1/NDUFA6/NDUFS5/NDUFV2/UQCRFS1/NDUFB5/PPIF/MPC2/MAPK12/NDUFA4/PIK3R1/NDUFV1	11.8289415441489
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	69/943	227/9376	3.02224132373482	ATP5F1E/SLC25A5/CYBA/COX6C/UQCRQ/NDUFB2/NDUFB1/COX5A/ATP5MC2/UQCRH/NFKBIA/GSTO1/NDUFA2/ATP5F1D/ATP5PF/ATP5MC3/UQCR11/ATP5PO/SLC25A6/NDUFB10/ATP5F1B/NCF1/NDUFA12/UQCR10/NDUFAB1/COX5B/COX6B1/SOD1/COX7B/COX6A1/COX7A2/UQCRB/COX7C/NDUFS6/COX8A/NDUFA11/NDUFB11/NQO1/NDUFB8/NDUFB4/VDAC2/MAP2K2/NDUFB6/ATP5F1C/AKR1C3/NDUFA13/NDUFA1/SDHD/PRKD3/RAC1/ACP1/VDAC3/NDUFB3/FOS/CYC1/ATP5PD/ATP5MC1/COX4I1/NFKB1/NDUFA6/NDUFS5/NDUFV2/UQCRFS1/NDUFB5/PPIF/MAPK12/NDUFA4/PIK3R1/NDUFV1	10.3135820978287
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	93/943	368/9376	2.51270229148416	PFN1/ACTB/ATP5F1E/PSMA2/TNFRSF1B/COX6C/PSMA7/UQCRQ/NDUFB2/ACTG1/NDUFB1/COX5A/ATP5MC2/CYCS/UQCRH/NDUFA2/ATP5F1D/ATP5PF/TUBB/TUBA1B/PSMA4/ATP5MC3/UQCR11/PSMB1/ATP5PO/PSMB3/BID/NDUFB10/ATP5F1B/HNRNPA3/NDUFA12/CHCHD10/UQCR10/SRSF7/NDUFAB1/COX5B/HNRNPA1/COX6B1/TNF/SOD1/COX7B/COX6A1/ALYREF/COX7A2/BAX/UQCRB/COX7C/SEM1/NDUFS6/COX8A/NDUFA11/NDUFB11/VCP/PSMB4/NDUFB8/HNRNPA2B1/NDUFB4/PSMB2/DCTN3/NDUFB6/TUBA4A/ATP5F1C/PSMD8/NDUFA13/NDUFA1/PSMC5/SDHD/PSMB6/RAC1/NXT1/NDUFB3/DCTN6/PSMC4/CYC1/ATP5PD/ATP5MC1/COX4I1/PSMA5/NDUFA6/NDUFS5/NDUFV2/PSMD13/UQCRFS1/NDUFB5/RAB1A/PSMC1/PSMA1/PSMD9/CASP1/PSMA3/MAPK12/NDUFA4/NDUFV1	9.89950820118714
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	54/943	157/9376	3.41979453026322	COX6C/UQCRQ/NDUFB2/NDUFB1/COX5A/TGFB1/FASLG/CYCS/UQCRH/CDC42/NDUFA2/UQCR11/BID/NDUFB10/NDUFA12/UQCR10/NDUFAB1/COX5B/COX6B1/TNF/COX7B/COX6A1/COX7A2/BAX/UQCRB/COX7C/NDUFS6/COX8A/NDUFA11/NDUFB11/NDUFB8/NDUFB4/NDUFB6/NDUFA13/NDUFA1/SDHD/RAC1/NDUFB3/FOS/CYC1/IL1B/COX4I1/NFKB1/SREBF1/NDUFA6/NDUFS5/NDUFV2/UQCRFS1/NDUFB5/CXCL8/MAPK12/NDUFA4/PIK3R1/NDUFV1	10.2243767439855
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	54/943	158/9376	3.39815026108434	MCM6/E2F1/CCND2/CDC6/CDC45/TGFB1/CDT1/CHEK1/ORC6/MCM3/MCM7/PCNA/MAD2L1/YWHAB/CDK1/ESCO2/MYC/RBX1/ANAPC11/MCM5/PKMYT1/CDK4/BUB3/KNL1/GADD45B/NDC80/PTTG1/CCND3/CCNE2/MAD2L2/RAD21/CDCA5/SGO1/BUB1B/E2F2/CDC25B/DDX11/PPP2CA/BUB1/TTK/CDC25A/E2F3/MCM4/CDK2/HDAC1/ORC1/TFDP1/PPP2R1A/SKP1/AURKB/MCM2/YWHAQ/CDC7/HDAC2	10.1656936363689
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	68/943	235/9376	2.87704699803705	ACTB/ATP5F1E/COX6C/ATP5MG/UQCRQ/NDUFB2/ACTG1/ATP5ME/NDUFB1/COX5A/ATP5MC2/UQCRH/NDUFA2/ATP5F1D/ATP5PF/ATP5MC3/UQCR11/ATP5PO/RPS6/NDUFB10/ATP5F1B/COX17/NDUFA12/UQCR10/NDUFAB1/COX5B/COX6B1/GNAS/COX7B/COX6A1/COX7A2/UQCRB/ADCY3/COX7C/NDUFS6/RHEB/COX8A/NDUFAF8/NDUFA11/NDUFB11/COX14/NDUFB8/ATP5MF/BMP8A/NDUFB4/DPF3/NDUFB6/ATP5F1C/NDUFA13/NDUFA1/SDHD/NDUFB3/COA3/CYC1/ATP5PD/ATP5MC1/PRKACB/COX4I1/CREB3L2/NDUFA6/NDUFS5/NDUFV2/UQCRFS1/NDUFB5/ACTL6A/MAPK12/NDUFA4/NDUFV1	9.74456950890098
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	62/943	205/9376	3.00707136021519	B2M/HLA-C/VIM/HLA-DRA/HLA-A/HLA-B/ISG15/HLA-DPA1/HLA-F/HLA-E/HLA-DRB5/CD247/E2F1/CCND2/TNFAIP3/HLA-DPB1/CYCS/NFKBIA/RUNX3/HLA-DRB1/BID/TAP1/STAT1/HLA-DQA2/MYC/IRF9/TNF/CD3E/CDK4/CALR/PDIA3/BAX/SEM1/GADD45B/CD44/CCND3/CCNE2/OAS2/HLA-DQA1/E2F2/IRF7/PSMD8/PSMC5/JAK3/RAC1/HLA-DQB1/RELB/PSMC4/E2F3/CDK2/HDAC1/OAS1/NFKB1/NFKB2/PSMD13/HLA-DMA/PSMC1/CD58/ICAM1/MAPK12/HDAC2/PIK3R1	9.7158730607394
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	107/943	480/9376	2.2164015553199	ATP5F1E/UBC/SLC25A5/PSMA2/CALM3/TNFRSF1B/COX6C/CALM1/PSMA7/UQCRQ/UBA52/NDUFB2/NDUFB1/COX5A/ATP5MC2/FASLG/RPS27A/CYCS/UQCRH/CSNK2B/PRKCB/NDUFA2/ATP5F1D/ATP5PF/TUBB/TUBA1B/PSMA4/UBB/ATP5MC3/UQCR11/PSMB1/ATP5PO/PSMB3/BID/SLC25A6/NDUFB10/ATP5F1B/NDUFA12/UQCR10/NDUFAB1/UBE2L6/COX5B/ATP2A3/COX6B1/TNF/SOD1/COX7B/COX6A1/COX7A2/BAX/UQCRB/PARK7/COX7C/SEM1/ITPR2/NDUFS6/COX8A/NDUFA11/NDUFB11/VCP/UBE2L3/PSMB4/NDUFB8/NDUFB4/PSMB2/VDAC2/DCTN3/MAP2K2/NDUFB6/TUBA4A/ATP5F1C/PSMD8/NDUFA13/NDUFA1/PSMC5/SDHD/PSMB6/RAC1/VDAC3/PRNP/NDUFB3/DCTN6/PSMC4/CYC1/ATP5PD/ATP5MC1/IL1B/COX4I1/PSMA5/NFKB1/NDUFA6/NDUFS5/NDUFV2/PSMD13/UQCRFS1/NDUFB5/RAB1A/PPIF/PSMC1/PSMA1/HSD17B10/PSMD9/PSMA3/MAPK12/NDUFA4/TRPC3/NDUFV1	9.1485155952567
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	36/943	82/9376	4.36510358740915	B2M/HLA-C/HLA-DRA/HLA-A/CD74/HLA-B/HLA-DPA1/HLA-F/HLA-E/HLA-DRB5/KLRC3/PSME2/KLRC1/KLRC2/PSME1/IFNG/KLRD1/HLA-DPB1/HLA-DRB1/TAP1/KIR2DL4/HSPA8/HLA-DQA2/IFI30/TNF/CALR/PDIA3/KLRC4/HLA-DQA1/HSPA6/HSP90AB1/HLA-DQB1/CTSL/HLA-DMA/KIR2DL3/CTSB	10.2342132969504
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	90/943	388/9376	2.30630473046102	ATP5F1E/SLC25A5/GAPDH/PSMA2/CALM3/APOE/COX6C/CALM1/PSMA7/UQCRQ/NDUFB2/NDUFB1/COX5A/ATP5MC2/CYCS/UQCRH/CSNK2B/NDUFA2/ATP5F1D/ATP5PF/TUBB/TUBA1B/PSMA4/ATP5MC3/UQCR11/PSMB1/ATP5PO/PSMB3/BID/SLC25A6/NDUFB10/ATP5F1B/NDUFA12/UQCR10/NDUFAB1/COX5B/ATP2A3/COX6B1/TNF/COX7B/COX6A1/COX7A2/UQCRB/COX7C/SEM1/ITPR2/NDUFS6/COX8A/NDUFA11/NDUFB11/PSMB4/NDUFB8/NDUFB4/PSMB2/VDAC2/MAP2K2/NDUFB6/TUBA4A/ATP5F1C/PSMD8/NDUFA13/NDUFA1/PSMC5/SDHD/PSMB6/VDAC3/NDUFB3/PSMC4/CYC1/ATP5PD/ATP5MC1/IL1B/COX4I1/PSMA5/NFKB1/NDUFA6/NDUFS5/NDUFV2/PSMD13/UQCRFS1/NDUFB5/PPIF/PSMC1/PSMA1/HSD17B10/PSMD9/PSMA3/NDUFA4/PIK3R1/NDUFV1	8.7877817997988
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	62/943	224/9376	2.75200727162551	B2M/HLA-C/HLA-DRA/HLA-A/ITGB2/ZFP36/HLA-B/SLC25A5/HLA-DPA1/HLA-F/HLA-E/IL2RG/HLA-DRB5/RANBP1/IL2RB/E2F1/LCK/CCND2/RAN/TGFB1/CHEK1/HLA-DPB1/NFKBIA/HLA-DRB1/SLC25A6/ETS1/MAD2L1/HLA-DQA2/MYC/ANAPC11/TNF/CD3E/CDK4/CALR/BUB3/BAX/ADCY3/PTTG1/CSF2/CCND3/CCNE2/VDAC2/HLA-DQA1/BUB1B/MAP2K2/E2F2/JAK3/TSPO/VDAC3/FOS/HLA-DQB1/RELB/E2F3/PRKACB/CDK2/CREB3L2/EGR2/NFKB1/NFKB2/HLA-DMA/ICAM1/PIK3R1	8.87467263996297
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	25/943	46/9376	5.40366084190142	PSMB9/PSMA2/PSMB8/PSME2/PSMB10/PSME1/IFNG/PSMA7/POMP/PSMA4/PSMB1/PSMB3/SEM1/PSMB4/PSMB2/PSMD8/PSMC5/PSMB6/PSMC4/PSMA5/PSMD13/PSMC1/PSMA1/PSMD9/PSMA3	10.0115746914869
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	23/943	45/9376	5.08184281842818	HLA-C/HLA-DRA/HLA-A/GZMB/HLA-B/HLA-DPA1/HLA-F/HLA-E/HLA-DRB5/KLRC1/PRF1/IFNG/KLRD1/FASLG/HLA-DPB1/HLA-DRB1/HLA-DQA2/TNF/HLA-DQA1/HLA-DQB1/IL1B/HLA-DMA/KIR2DL3	9.17801733607391
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	42/943	133/9376	3.13981135234693	HLA-C/HLA-A/FCER1G/HCST/RAC2/ITGB2/TYROBP/GZMB/HLA-B/CD48/HLA-E/KLRK1/CD247/KLRC3/KLRC1/LCP2/PRF1/KLRC2/LCK/IFNG/LAT2/SH2D1A/KLRD1/FASLG/PRKCB/NCR3/BID/SH2D1B/KIR2DL4/ZAP70/TNF/LAT/CSF2/CD244/FCGR3A/MAP2K2/NCR1/FYN/RAC1/KIR2DL3/ICAM1/PIK3R1	8.31084658779801
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	57/943	227/9376	2.49663413699833	B2M/HLA-C/CCL4/HLA-A/CCL3/RAC2/CXCR4/HLA-B/CALM3/HLA-F/HLA-E/GNG2/GNG5/E2F1/CALM1/GNB2/PTGER4/FASLG/CCL5/CYCS/NFKBIA/PRKCB/RHOA/BID/TAP1/MYC/TNF/CDK4/GNAS/CALR/PDIA3/BAX/CCL4L2/EIF4EBP1/ADCY3/GNGT2/ITPR2/RHEB/GNAI2/IL10RA/MAP2K2/E2F2/RAC1/E2F3/CCR5/IL1B/PRKACB/CREB3L2/ARHGEF1/NFKB1/GNB1/CGAS/CCL3L1/GNG10/CXCL8/MAPK12/PIK3R1	7.63294610844844
Human Diseases	Immune disease	hsa05330	Allograft rejection	19/943	39/9376	4.84389700084292	HLA-C/HLA-DRA/HLA-A/GZMB/HLA-B/HLA-DPA1/HLA-F/HLA-E/HLA-DRB5/PRF1/IFNG/FASLG/HLA-DPB1/HLA-DRB1/HLA-DQA2/TNF/HLA-DQA1/HLA-DQB1/HLA-DMA	8.04360620616212
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	18/943	36/9376	4.97136797454931	MCM6/MCM3/MCM7/PCNA/POLE4/MCM5/FEN1/RPA2/RPA3/RFC4/RFC2/RNASEH2C/SSBP1/LIG1/MCM4/RPA1/MCM2/POLE3	7.98304129791829
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	20/943	44/9376	4.51942543140846	HLA-C/HLA-DRA/HLA-A/GZMB/HLA-B/HLA-DPA1/HLA-F/HLA-E/HLA-DRB5/PRF1/IFNG/FASLG/HLA-DPB1/HLA-DRB1/HLA-DQA2/TNF/HLA-DQA1/HLA-DQB1/IL1B/HLA-DMA	7.82458252769938
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	33/943	109/9376	3.01018611302986	HLA-DRA/HLA-DPA1/IL2RG/HLA-DRB5/IL2RB/CD247/LCK/IFNG/TGFB1/HLA-DPB1/NFKBIA/HLA-DRB1/IL27RA/PRKCQ/IL21R/ZAP70/STAT1/HLA-DQA2/CD3E/GATA3/LAT/IRF4/HLA-DQA1/JAK3/HSP90AB1/FOS/HLA-DQB1/IL1B/IL12RB1/NFKB1/TBX21/HLA-DMA/MAPK12	7.05879176390043
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	41/943	155/9376	2.63001402524544	HLA-C/HLA-DRA/HLA-A/ACTB/CORO1A/ITGB2/HLA-B/CYBA/HLA-DPA1/HLA-F/HLA-E/HLA-DRB5/SEC61G/ACTG1/SEC61B/HLA-DPB1/TUBB/TUBA1B/HLA-DRB1/NCF1/TAP1/ATP6V1F/ATP6V0B/HLA-DQA2/ATP6V0C/CALR/MARCO/HLA-DQA1/FCGR3A/RAB5C/CD14/TUBA4A/RAC1/LAMP1/TCIRG1/ATP6V1G1/HLA-DQB1/ITGAM/FCGR2B/CTSL/HLA-DMA	6.84255999142177
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	45/943	180/9376	2.48568398727466	B2M/HLA-C/HLA-DRA/HLA-A/CD74/BST2/HLA-B/HLA-DPA1/HLA-F/HLA-E/HLA-DRB5/IFNG/PPP1CA/SRSF2/FASLG/HLA-DPB1/CCL5/CYCS/NFKBIA/HLA-DRB1/SRSF9/BID/TAP1/SRSF7/STAT1/HLA-DQA2/IRF9/TNF/CALR/ALYREF/PDIA3/BAX/EIF4EBP1/RHEB/OAS2/HLA-DQA1/IRF7/HLA-DQB1/IL1B/OAS1/TNFSF14/NFKB1/HLA-DMA/CGAS/PIK3R1	6.72997805686536
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	30/943	95/9376	3.13981135234693	HLA-DRA/CCL3/ITGB2/HLA-DPA1/HLA-DRB5/IFNG/TGFB1/HLA-DPB1/CCL5/HLA-DRB1/ATP6V1F/ATP6V0B/HLA-DQA2/ATP6V0C/TNF/ACP5/CXCL3/LTB/CSF2/HLA-DQA1/TCIRG1/ATP6V1G1/FOS/HLA-DQB1/IL1B/CTSL/HLA-DMA/CCL3L1/CXCL8/ICAM1	7.0095532279897
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	25/943	70/9376	3.55097712467808	HLA-C/HLA-DRA/HLA-A/ACTB/RAC2/ITGB2/HLA-B/HLA-DPA1/HLA-F/HLA-E/HLA-DRB5/PRF1/ACTG1/HLA-DPB1/CYCS/SNTB1/HLA-DRB1/BID/HLA-DQA2/HLA-DQA1/FYN/RAC1/HLA-DQB1/HLA-DMA/ICAM1	7.163487287244
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	22/943	56/9376	3.90607483714589	ITGB2/CYCS/EEF1A1/NFKBIA/HSPA8/EEF1G/TNF/PYCARD/ARF1/CXCL3/VCP/RAB1B/CD14/HSPA6/IL1B/ITGAM/NFKB1/NFKB2/RAB1A/CXCL8/CLK1/CASP1	7.29362257106827
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	47/943	196/9376	2.38422749799814	HLA-C/HLA-A/CLEC2B/ZFP36/HLA-B/UBC/CALM3/HLA-F/HLA-E/GNG2/PREX1/GNG5/E2F1/CALM1/GNB2/UBA52/RPS27A/CYCS/NFKBIA/UBB/BID/STAT1/MYC/IRF9/CDK4/PIK3CG/BAX/GNGT2/ITPR2/CXCL3/CSF2/PIK3R6/MAP2K2/E2F2/IRF7/PIK3R5/RAC1/FOS/E2F3/CCR5/NFKB1/GNB1/GNG10/CXCL8/ICAM1/MAPK12/PIK3R1	6.54884334569465
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	29/943	93/9376	3.10042303789097	HLA-DRA/HLA-DPA1/IL2RG/HLA-DRB5/IL2RB/CD247/LCK/IFNG/HLA-DPB1/NFKBIA/RUNX3/HLA-DRB1/PRKCQ/ZAP70/STAT1/HLA-DQA2/CD3E/GATA3/LAT/HLA-DQA1/JAK3/IL12RB2/FOS/HLA-DQB1/IL12RB1/NFKB1/TBX21/HLA-DMA/MAPK12	6.80698050080492
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	37/943	138/9376	2.66580601533804	ACTB/RAC2/ARPC2/ARPC3/ARPC1B/LCP2/FYB1/LCK/ACTG1/NFKBIA/WIPF1/CDC42/RHOA/ZAP70/TNF/WAS/PYCARD/FN1/LAT/ARPC4/ACTR2/MAP2K2/ACTR3/RAC1/SKAP2/FOS/ARF6/ARPC5L/ARPC5/IL1B/ARHGEF1/NFKB1/RHOG/CXCL8/CASP1/MAPK12/PIK3R1	6.59212486037339
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	49/943	214/9376	2.27660776404595	B2M/HLA-C/HLA-A/RAC2/CXCR4/CFL1/BST2/HLA-B/CALM3/HLA-F/HLA-E/GNG2/TNFRSF1B/GNG5/CD247/CALM1/GNB2/APOBEC3G/FASLG/CHEK1/CYCS/NFKBIA/PRKCB/APOBEC3H/BID/TAP1/CDK1/ELOB/RBX1/TNF/CD3E/CALR/PDIA3/BAX/GNGT2/ITPR2/GNAI2/MAP2K2/RAC1/FOS/CCR5/NFKB1/GNB1/APOBEC3C/SKP1/CGAS/GNG10/MAPK12/PIK3R1	6.31712773707544
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	54/943	248/9376	2.1649505695618	PFN1/ACTB/ARPC2/ARPC3/GAPDH/RHOH/FLNA/ARPC1B/ACTG1/PTPRC/MYL12A/CYCS/NCKAP1L/NFKBIA/BRK1/CDC42/TUBB/TUBA1B/RHOA/RPS3/MYC/MYL12B/TNF/PYCARD/PIK3CG/BAX/ARF1/ARPC4/ACTR2/DCTN3/MAP2K2/RAB5C/TXN/CD14/TUBA4A/ACTR3/CYFIP2/RAC1/HSP90AB1/FOS/DYNLT1/DCTN6/ARF6/ARPC5L/ARPC5/IL1B/NFKB1/SKP1/RHOG/DYNLL1/S100A10/CXCL8/CASP1/MAPK12	6.21721601671195
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	39/943	157/9376	2.4698516051901	HLA-C/HLA-A/ZFP36L2/HLA-B/SLC25A5/CALM3/HLA-F/HLA-E/E2F1/RASSF5/CALM1/CCND2/PPP1CA/MYBL2/TGFB1/CHEK1/SLC25A6/ETS1/KIR2DL4/CDK1/MYC/CDK4/EIF4EBP1/ITPR2/RHEB/GADD45B/CCND3/CCNE2/VDAC2/MAP2K2/E2F2/VDAC3/CDC25A/E2F3/CDK2/NFKB1/CXCL8/MAPK12/PIK3R1	6.210575477076
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	25/943	78/9376	3.18677434265981	HLA-DRA/ITGB2/CYBA/HLA-DPA1/HLA-DRB5/IFNG/TGFB1/HLA-DPB1/EEF1A1/NFKBIA/PRKCB/HLA-DRB1/NCF1/STAT1/HLA-DQA2/TNF/HLA-DQA1/FCGR3A/FOS/HLA-DQB1/IL1B/ITGAM/NFKB1/HLA-DMA/MAPK12	6.48495451790649
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	41/943	173/9376	2.35637094747424	HLA-DRA/ACTB/SLC25A5/HLA-DPA1/HLA-DRB5/IFNG/ACTG1/FASLG/HLA-DPB1/CCL5/CYCS/NFKBIA/RAB11A/PRKCB/HLA-DRB1/BID/SLC25A6/STAT1/HLA-DQA2/IRF9/TNF/CDK4/PYCARD/BAX/CCND3/OAS2/HLA-DQA1/MAP2K2/IRF7/MX1/NXT1/HLA-DQB1/IL1B/MX2/OAS1/NFKB1/HLA-DMA/CXCL8/ICAM1/CASP1/PIK3R1	6.02125824314263
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	44/943	193/9376	2.26673772932818	CCL4/XCL1/CCL3/RAC2/CXCR4/XCL2/GNG2/PREX1/GNG5/GNB2/ITK/DOCK2/CCL5/NFKBIA/PRKCB/CDC42/CXCR3/RHOA/NCF1/STAT1/WAS/PIK3CG/CCL4L2/ADCY3/GNGT2/CXCL3/FGR/GNAI2/ARRB2/PIK3R6/GRK5/PIK3R5/JAK3/RAC1/CCR5/PRKACB/NFKB1/GNB1/CCL3L1/CCR9/GNG10/CXCL8/RAP1B/PIK3R1	5.94598080402555
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	41/943	181/9376	2.25222195532068	HLA-DRA/CD74/CORO1A/FCER1G/ITGB2/LSP1/CALM3/HLA-DPA1/HLA-DRB5/CALM1/CTSD/IFNG/TGFB1/HLA-DPB1/CYCS/RHOA/HLA-DRB1/BID/ATP6V0B/STAT1/HLA-DQA2/HSPA9/ATP6V0C/TNF/BAX/CEBPB/HLA-DQA1/FCGR3A/ITGAX/IL10RA/RAB5C/CD14/LAMP1/TCIRG1/HLA-DQB1/IL1B/ITGAM/FCGR2B/NFKB1/HLA-DMA/MAPK12	5.68846603200818
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	21/943	66/9376	3.16359780198592	HLA-DRA/HLA-DPA1/IL2RG/HLA-DRB5/IFNG/TGFB1/HLA-DPB1/HLA-DRB1/IL21R/STAT1/HLA-DQA2/TNF/GATA3/HLA-DQA1/IL12RB2/HLA-DQB1/IL1B/IL12RB1/NFKB1/TBX21/HLA-DMA	5.89826245234175
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	43/943	200/9376	2.1376882290562	ACTB/ARPC2/ARPC3/GAPDH/ARPC1B/ACTG1/FASLG/CYCS/NCKAP1L/NFKBIA/BRK1/WIPF1/CDC42/TUBB/TUBA1B/RHOA/TMBIM6/RPS3/TNF/PYCARD/BAX/ARF1/MYO1F/NCL/ARPC4/MYO1G/ACTR2/TUBA4A/FYN/ACTR3/CYFIP2/RAC1/FOS/ARF6/ARPC5L/ARPC5/IL1B/ARHGEF1/NFKB1/RAB1A/CXCL8/CASP1/MAPK12	5.43828538749925
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	23/943	78/9376	2.93183239524703	CFL1/ITGB2/CALM3/CALM1/C1QA/IRF8/IRF1/RHOA/C1QB/C1QC/TNF/SERPING1/PYCARD/GNAI2/CD14/FOS/IL1B/ITGAM/NFKB1/C4BPA/CXCL8/CASP1/MAPK12	5.7289154052162
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	27/943	105/9376	2.55670352976822	CCL4/LCK/TNFAIP3/NFKBIA/CSNK2B/PRKCB/BCL2A1/PRKCQ/ZAP70/CARD11/TNF/CCL4L2/CXCL3/LTB/GADD45B/LAT/TRAF1/CD14/PARP1/RELB/IL1B/TNFSF14/NFKB1/NFKB2/CXCL8/UBE2I/ICAM1	5.36398683853107
Human Diseases	Infectious disease: viral	hsa05162	Measles	32/943	136/9376	2.33946728214085	MSN/IL2RG/IL2RB/CCND2/TNFAIP3/FASLG/CYCS/NFKBIA/CSNK2B/BID/HSPA8/STAT1/IRF9/CD3E/CDK4/BAX/CCND3/CCNE2/OAS2/IRF7/RACK1/HSPA6/MX1/JAK3/FOS/IL1B/MX2/CDK2/FCGR2B/OAS1/NFKB1/PIK3R1	5.26157800009322
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	28/943	112/9376	2.48568398727466	HLA-DRA/HLA-DPA1/HLA-DRB5/IFNG/TGFB1/HLA-DPB1/CYCS/NFKBIA/HLA-DRB1/HSPA8/STAT1/HLA-DQA2/TNF/PIK3CG/GNAI2/PIK3R6/HLA-DQA1/IL10RA/HSPA6/PIK3R5/HLA-DQB1/LDLR/CCR5/NFKB1/SOCS1/HLA-DMA/PPIF/MAPK12	5.28915890674047
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	33/943	149/9376	2.2020824585252	GNG2/GNG5/GNB2/NDUFB2/NDUFB1/PRKCB/NDUFA2/NDUFB10/NDUFA12/NDUFAB1/ADCY3/GNGT2/ITPR2/NDUFS6/NDUFA11/NDUFB11/GNAI2/NDUFB8/NDUFB4/NDUFB6/NDUFA13/NDUFA1/NDUFB3/PRKACB/NDUFA6/NDUFS5/NDUFV2/GNB1/NDUFB5/GNG10/MAPK12/NDUFA4/NDUFV1	4.94592547371664
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	48/943	253/9376	1.88636887571832	PFN1/ACTB/ARPC2/ARPC3/UBC/ARPC1B/UBA52/ACTG1/MYL12A/RPS27A/CCL5/CYCS/NFKBIA/CDC42/UBB/RHOA/PRKCQ/SEPTIN6/RBX1/MYL12B/TNF/PYCARD/BAX/ARF1/ITPR2/CD44/CSF2/ARPC4/ACTR2/CD14/ACTR3/UBE2N/RAC1/CBX3/ARF6/ARPC5L/ARPC5/IL1B/NFKB1/CAPNS1/SEPTIN7/UBE2V1/SKP1/CGAS/CXCL8/CASP1/MAPK12/PIK3R1	4.77921265495965
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	17/943	54/9376	3.13012057656808	HLA-C/HLA-DRA/HLA-A/GZMB/HLA-B/HLA-DPA1/HLA-F/HLA-E/HLA-DRB5/PRF1/FASLG/HLA-DPB1/HLA-DRB1/HLA-DQA2/HLA-DQA1/HLA-DQB1/HLA-DMA	5.24924632209022
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	25/943	103/9376	2.4132854245385	CCL3/CD247/IFNG/C1QA/TGFB1/FASLG/CCL5/NFKBIA/C1QB/C1QC/TNF/CD3E/GNAS/CALR/GNAI2/PPP2CA/FOS/IL1B/NFKB1/PPP2R2B/PPP2R1A/CCL3L1/CXCL8/MAPK12/PIK3R1	4.82268389572571
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	28/943	122/9376	2.28193939815378	CD247/LCP2/LCK/IFNG/ITK/PTPRC/NFKBIA/CDC42/RHOA/PRKCQ/ZAP70/CARD11/TNF/CD3E/CDK4/LAT/CSF2/MAP2K2/FYN/PPP2CA/ICOS/FOS/GRAP2/NFKB1/PPP2R2B/PPP2R1A/MAPK12/PIK3R1	4.76577019834058
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	24/943	98/9376	2.4349557426364	RAC2/CFL1/ARPC2/ARPC3/ARPC1B/PTPRC/PRKCB/CDC42/NCF1/INPP5D/WAS/LAT/ARPC4/ACTR2/BIN1/FCGR3A/ACTR3/RAC1/ARF6/ARPC5L/ARPC5/FCGR2B/VASP/PIK3R1	4.77501560025168
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	30/943	137/9376	2.17724144870773	ACTB/CTSW/GZMB/CTSC/PRF1/CTSD/LMNB1/ACTG1/FASLG/CYCS/NFKBIA/TUBA1B/BCL2A1/BID/TNF/BAX/ITPR2/GADD45B/TRAF1/MAP2K2/TUBA4A/PARP1/FOS/MCL1/BIRC5/NFKB1/CTSL/CTSB/CTSZ/PIK3R1	4.64155797036942
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	10/943	23/9376	4.32292867352114	PCNA/RPA2/RPA3/RFC4/RFC2/MSH6/SSBP1/EXO1/LIG1/RPA1	5.3353130221731
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	30/943	142/9376	2.1005780174152	JUND/TYROBP/CYBA/JUNB/LCP2/LCK/IFNG/TGFB1/NFKBIA/NCF1/STAT1/ATP2A3/IRF9/TNF/FOSB/ACP5/ITPR2/FCGR3A/FYN/RAC1/FOS/RELB/IL1B/FCGR2B/NFKB1/SOCS1/FOSL2/NFKB2/MAPK12/PIK3R1	4.41896442824419
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	20/943	78/9376	2.54941947412785	ACTB/ARPC2/ARPC3/ARPC1B/ACTG1/CDC42/RHOA/SEPTIN6/SEPTIN1/FN1/ARPC4/ACTR2/MAD2L2/ACTR3/RAC1/ARPC5L/ARPC5/CLTB/RHOG/PIK3R1	4.59485673618076
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	26/943	116/9376	2.22854426445314	ACTB/RAC2/CXCR4/ITGB2/MSN/CYBA/RHOH/RASSF5/ACTG1/ITK/MYL12A/PRKCB/CDC42/RHOA/NCF1/MYL12B/GNAI2/CD99/RAC1/PECAM1/ITGAM/VASP/RAP1B/ICAM1/MAPK12/PIK3R1	4.45209829634507
Organismal Systems	Immune system	hsa04611	Platelet activation	27/943	126/9376	2.13058627480685	ACTB/FCER1G/APBB1IP/LCP2/ACTG1/PPP1CA/COL1A2/MYL12A/RHOA/MYL12B/GNAS/PIK3CG/ADCY3/VAMP8/ITPR2/FERMT3/GNAI2/PIK3R6/FYN/PIK3R5/COL1A1/PRKACB/ARHGEF1/VASP/RAP1B/MAPK12/PIK3R1	4.27236697610098
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	55/943	333/9376	1.6421936252265	HLA-C/HLA-A/HLA-B/ISG15/HLA-F/HLA-E/E2F1/CCND2/COL1A2/OASL/SPP1/PTGER4/FASLG/CDC42/IRF1/ATP6V1F/ATP6V0B/STAT1/PKM/BCAP31/ATP6V0C/IRF9/TNF/CDK4/GNAS/BAX/EIF4EBP1/FN1/RHEB/MFNG/ITGB7/ITGA1/CCND3/HES6/CCNE2/MAP2K2/PPP2CA/MX1/TCIRG1/ATP6V1G1/COL6A1/COL1A1/PRKACB/MX2/CDK2/HDAC1/CREB3L2/NFKB1/PPP2R2B/PDGFRB/PPP2R1A/LFNG/PSMC1/HDAC2/PIK3R1	3.99008618026059
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	29/943	142/9376	2.03055875016803	ACTB/RAC2/CALM3/SUMO2/CYBA/CALM1/IFNG/ACTG1/GSTO1/DUSP1/RHOA/GSTP1/NCF1/SUMO3/TNF/NQO1/SUMO1/TXN/KLF2/RAC1/PECAM1/HSP90AB1/FOS/IL1B/NFKB1/CTSL/ICAM1/MAPK12/PIK3R1	4.13782792873127
Human Diseases	Immune disease	hsa05310	Asthma	11/943	32/9376	3.41781548250265	HLA-DRA/FCER1G/HLA-DPA1/HLA-DRB5/HLA-DPB1/HLA-DRB1/HLA-DQA2/TNF/HLA-DQA1/HLA-DQB1/HLA-DMA	4.58123070599986
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	29/943	144/9376	2.00235654530458	SLC25A5/PSMA2/PSMA7/CYCS/PRKCB/PSMA4/PSMB1/PSMB3/SLC25A6/ATP2A3/SEM1/ITPR2/PSMB4/PSMB2/VDAC2/PSMD8/PSMC5/PSMB6/VDAC3/PSMC4/PSMA5/PSMD13/PPIF/PSMC1/PSMA1/PSMD9/PSMA3/TRPC3/PIK3R1	4.05327446922366
NA	NA	hsa04517	IgSF CAM signaling	50/943	299/9376	1.66266487443121	ACTB/ITGB2/ARPC2/ARPC3/MSN/CD48/ARPC1B/ICAM3/LCP2/LCK/ACTG1/SH2D1A/MYL12A/PRKCB/CDC42/TUBB/TUBA1B/RHOA/SLAMF7/PRKCQ/CD2/SH2D1B/DOK2/CRTAM/MYL6/INPP5D/MYL12B/CSK/TIGIT/NCAM1/ARPC4/ACTR2/CD244/ITGAX/MAP2K2/TUBA4A/FYN/CD96/ACTR3/RAC1/ARF6/ARPC5L/ARPC5/ITGAM/PLXNA4/DYNLL1/RAP1B/ICAM1/MAPK12/PIK3R1	3.89411534748934
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	14/943	50/9376	2.78396606574761	HLA-DRA/CXCR4/HLA-DPA1/HLA-DRB5/TGFB1/HLA-DPB1/HLA-DRB1/HLA-DQA2/ITGB7/HLA-DQA1/ICOS/HLA-DQB1/HLA-DMA/CCR9	4.22935675244021
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	37/943	205/9376	1.79454258593487	HLA-C/HLA-A/HLA-B/HLA-F/HLA-E/RANBP1/CCND2/CHEK1/NFKBIA/CDC42/RHOA/YWHAB/CDK1/PKM/IRF9/CDK4/BAX/TRAF1/GTF2A2/CCND3/CCNE2/IRF7/JAK3/RAC1/VDAC3/CCR5/PRKACB/CDK2/HDAC1/CREB3L2/EGR2/NFKB1/NFKB2/YWHAQ/PSMC1/HDAC2/PIK3R1	3.84623838460192
Genetic Information Processing	Transcription	hsa03040	Spliceosome	42/943	243/9376	1.71849757144914	SNRPF/SNRPB/SNRPG/SRSF2/SNRPD2/PCBP1/SRSF9/SF3B6/SNRPD3/LSM7/SNU13/HNRNPA3/LSM5/SRSF7/HSPA8/LSM4/SNRPE/SF3B5/HNRNPA1/ALYREF/RBM8A/LSM3/SNRPB2/SF3B2/LSM2/ZMAT2/BUD31/SNRPC/HSPA6/PUF60/MAGOH/LSM8/SNRPA1/BCAS2/THOC6/CCDC12/SNRPA/HNRNPM/SF3B4/PPIH/SNRNP40/SNRPD1	3.79465368762316
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	14/943	51/9376	2.72937849583099	ACTB/SEC61G/ACTG1/SEC61B/ATP6V1F/ATP6V0B/ATP6V0C/GNAS/ARF1/ADCY3/TCIRG1/ATP6V1G1/PRKACB/KDELR2	4.1409611554915
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	16/943	63/9376	2.52513928865997	POLR2L/POLR2J/PCNA/RBX1/POLE4/POLR2K/RPA2/POLR2G/RPA3/RFC4/RFC2/LIG1/RPA1/POLR2F/POLE3/POLR2E	4.0614902649593
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	30/943	160/9376	1.86426299045599	HLA-C/HLA-DRA/HLA-A/ITGB2/HLA-B/HLA-DPA1/HLA-F/HLA-E/HLA-DRB5/ICAM3/PTPRC/SPN/HLA-DPB1/HLA-DRB1/CD2/HLA-DQA2/TIGIT/NCAM1/CD99/ITGB7/HLA-DQA1/VSIR/PECAM1/ICOS/HLA-DQB1/ITGAM/SELPLG/HLA-DMA/CD58/ICAM1	3.68710163153961
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	42/943	250/9376	1.67037963944857	HLA-C/HLA-A/CXCR4/ARPC2/HLA-B/ARPC3/HLA-F/HLA-E/IL2RG/IL2RB/ARPC1B/WIPF1/RAB11A/CDC42/ACAP1/RHOA/SH3KBP1/ARF5/HSPA8/ARF1/ARPC4/ARFGAP3/CHMP4A/ACTR2/ARRB2/BIN1/RAB5C/CAPZA1/GRK5/ACTR3/HSPA6/AP2S1/ARF6/ARPC5L/LDLR/CCR5/ARPC5/CHMP5/CLTB/CHMP2A/AP2M1/SNX3	3.59253511735747
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	30/943	163/9376	1.82995140167459	E2F1/TGFB1/FASLG/CYCS/NFKBIA/PRKCB/PCNA/BID/YWHAB/STAT1/MYC/TNF/BAX/CCNE2/MAP2K2/E2F2/IRF7/JAK3/VDAC3/FOS/E2F3/CDK2/BIRC5/CREB3L2/EGR2/NFKB1/YWHAQ/CXCL8/MAPK12/PIK3R1	3.57434413542357
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	29/943	156/9376	1.84832911874269	E2F1/IFNG/FASLG/CYCS/NFKBIA/BID/YWHAB/STAT1/MYC/IRF9/TNF/CDK4/BAX/OAS2/MAP2K2/E2F2/IRF7/PPP2CA/MX1/LDLR/E2F3/MX2/CDK2/OAS1/NFKB1/PPP2R2B/PPP2R1A/YWHAQ/PIK3R1	3.57282420020399
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	21/943	100/9376	2.08797454931071	HLA-DRA/CD7/HLA-DPA1/HLA-DRB5/CD37/HLA-DPB1/HLA-DRB1/CD2/HLA-DQA2/TNF/CD3E/CD44/CSF2/ITGA1/HLA-DQA1/CD14/HLA-DQB1/IL1B/ITGAM/IL9R/HLA-DMA	3.65753760962727
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	19/943	87/9376	2.17140210382614	COX6C/UQCRQ/COX5A/UQCRH/UQCR11/UQCR10/COX5B/ATP2A3/COX6B1/COX7B/COX6A1/COX7A2/UQCRB/COX7C/COX8A/TPM3/CYC1/COX4I1/UQCRFS1	3.67055367293357
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	39/943	232/9376	1.67140819833985	PFN1/ACTB/RAC2/CXCR4/CFL1/ITGB2/ARPC2/ARPC3/MSN/TMSB4X/ARPC1B/ACTG1/PPP1CA/MYL12A/NCKAP1L/BRK1/CDC42/RHOA/ITGAE/MYL12B/FN1/ARPC4/DIAPH3/ITGB7/ITGA1/ACTR2/ITGAX/MAP2K2/RGCC/ACTR3/CYFIP2/RAC1/ARPC5L/ARPC5/ITGAM/ARHGEF1/PDGFRB/ARHGEF6/PIK3R1	3.4626847806658
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	12/943	44/9376	2.71165525884508	PCNA/UNG/POLE4/FEN1/RFC4/RFC2/HMGB1/PARP1/LIG1/MPG/APEX1/POLE3	3.80544725064515
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	18/943	83/9376	2.15625598896115	CCL4/POLR2L/PCBP1/CCL5/NFKBIA/POLR2K/PYCARD/CCL4L2/IFI16/IRF7/IL1B/POLR3K/POLR2F/ZBP1/NFKB1/CGAS/POLR2E/CASP1	3.53806255523723
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	32/943	187/9376	1.70143075064789	CYBA/GPSM3/TNFAIP3/CCL5/NFKBIA/RHOA/PSTPIP1/GABARAP/STAT1/IRF9/TNF/PYCARD/CARD16/ITPR2/CXCL3/IFI16/OAS2/VDAC2/TXN/IRF7/GBP5/NLRP1/HSP90AB1/VDAC3/IL1B/OAS1/NFKB1/GABARAPL2/CXCL8/CTSB/CASP1/MAPK12	3.23982769295015
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	30/943	174/9376	1.71426481881011	SEC61G/SEC61B/TMEM258/PPP1R15A/HSPA8/RBX1/BCAP31/CALR/PDIA3/BAX/VCP/DAD1/SSR4/LMAN2/STUB1/HSPA6/P4HB/HSP90AB1/MAN1A1/PDIA6/UFD1/SKP1/SSR2/SVIP/UBXN1/KRTCAP2/BAG1/DNAJA1/STT3B/ERO1B	3.1801177693188
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	16/943	75/9376	2.12111700247437	RRM2/CCND2/CHEK1/CYCS/BID/CDK1/SIVA1/CDK4/BAX/GADD45B/CCND3/CCNE2/SHISA5/GTSE1/CDK2/STEAP3	3.25962156910449
NA	NA	hsa04518	Integrin signaling	27/943	154/9376	1.74320695211469	ACTB/RAC2/ITGB2/FLNA/ICAM3/CCND2/ACTG1/COL1A2/SPP1/TGFB1/CDC42/ITGAE/FN1/PARVG/FERMT3/ITGB7/ITGA1/CCND3/ITGAX/RAC1/COL6A1/COL1A1/ITGAM/PDGFRB/ARHGEF6/ICAM1/PIK3R1	3.10962485820641
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	20/943	103/9376	1.9306283396308	ITGB2/IFNG/COL1A2/TGFB1/PRKCB/TNF/GNAS/FN1/CXCL3/CSF2/RAB5C/CD14/PRDX1/COL1A1/IL1B/PRKACB/ITGAM/NFKB1/CXCL8/PIK3R1	3.17566871384737
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	11/943	44/9376	2.48568398727466	ARHGDIB/RAB11A/GNAS/ADCY3/ARHGDIA/RAB5C/DCTN6/PRKACB/CREB3L2/DYNLL1/VAMP2	3.30305534101337
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	10/943	38/9376	2.61650946028911	IL2RG/LCK/PTPRC/TAP1/ZAP70/UNG/CD3E/JAK3/ICOS/ADA	3.33882416814754
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	20/943	105/9376	1.89385446649498	FCER1G/LSP1/CALM3/CALM1/NFKBIA/IRF1/RHOA/STAT1/IRF9/TNF/PYCARD/ITPR2/RELB/IL1B/EGR2/NFKB1/NFKB2/CASP1/MAPK12/PIK3R1	3.07998504670645
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	16/943	77/9376	2.06602305435816	RAC2/E2F1/TGFB1/CDC42/STAT1/CDK4/BAX/GADD45B/RAD51/E2F2/RAC1/E2F3/NFKB1/BRCA2/ARHGEF6/PIK3R1	3.14082884079168
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	19/943	99/9376	1.90820184881691	HLA-DRA/ITGB2/HLA-DPA1/HLA-DRB5/C1QA/HLA-DPB1/C1QB/HLA-DRB1/HLA-DQA2/C1QC/KRT10/HLA-DQA1/FCGR3A/HLA-DQB1/ITGAM/FCGR2B/SELPLG/HLA-DMA/ICAM1	3.03771226760041
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	19/943	100/9376	1.88911983032874	CCL4/XCL1/CCL3/CXCR4/XCL2/IL2RG/TNFRSF1B/IL2RB/CCL5/CXCR3/TNF/CCL4L2/CXCL3/IL10RA/CCR5/TNFSF14/CCL3L1/CCR9/CXCL8	2.98903059906418
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	13/943	59/9376	2.19077232776749	TYMS/RRM2/UPP1/DUT/TK1/NME2/CTPS1/DCK/DTYMK/UCK2/RRM1/NME1/NT5C	3.06808315376394
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	24/943	138/9376	1.72917146940846	CALM3/CALM1/PPP1CA/MAD2L1/YWHAB/CDK1/RBX1/ANAPC11/PKMYT1/ADCY3/ITPR2/PTTG1/CCNE2/MAD2L2/SGO1/PPP2CA/BUB1/PRKACB/CDK2/PPP2R1A/SKP1/YWHAQ/SPDYE2/MAPK12	2.88556370111741
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	34/943	216/9376	1.56506028828404	CCL3/CALM3/CYBA/CALM1/FASLG/CCL5/CYCS/NFKBIA/CDC42/RHOA/BID/NCF1/HSPA8/TNF/PYCARD/BAX/CXCL3/CD14/IRF7/HSPA6/RAC1/HSP90AB1/FOS/LDLR/IL1B/ARHGEF1/NFKB1/CCL3L1/CXCL8/RAP1B/ICAM1/CASP1/MAPK12/PIK3R1	2.8094697468652
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	20/943	109/9376	1.8243552200181	CCL4/CCL3/SPP1/CCL5/NFKBIA/STAT1/IRF9/TNF/CCL4L2/MAP2K2/CD14/IRF7/RAC1/FOS/IL1B/NFKB1/CCL3L1/CXCL8/MAPK12/PIK3R1	2.89473288063931
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	28/943	170/9376	1.6376270974986	ACTB/ARPC2/ARPC3/MSN/ARPC1B/ACTG1/MYL12A/CDC42/RAB8B/TUBA1B/RHOA/PCNA/MYL6/MYL12B/CDK4/WAS/ARPC4/ACTR2/TUBA4A/PPP2CA/ACTR3/RAC1/ARPC5L/ARPC5/PRKACB/PPP2R2B/VASP/PPP2R1A	2.80547352709241
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	11/943	50/9376	2.1874019088017	ITGB2/GYPC/KLRB1/KLRK1/IFNG/TGFB1/TNF/PECAM1/IL1B/CXCL8/ICAM1	2.81504585612523
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	8/943	31/9376	2.56586734170287	SEC61G/SRP14/SEC61B/SPCS1/SEC11A/SPCS2/SRP9/SRP19	2.92009240600199
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	16/943	85/9376	1.87157382571268	TYMS/RRM2/UPP1/DUT/GUK1/TK1/NME2/CTPS1/APRT/DCK/DTYMK/UCK2/RRM1/ADA/NME1/NT5C	2.69918621128328
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	14/943	71/9376	1.96053948292085	CCL5/NFKBIA/CDC42/ATP6V1F/ATP6V0B/ATP6V0C/CSK/CXCL3/RAC1/TCIRG1/ATP6V1G1/NFKB1/CXCL8/MAPK12	2.71666846336466
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	17/943	93/9376	1.81748936703953	E2F1/CKS1B/CYCS/NFKBIA/MYC/CDK4/BAX/FN1/GADD45B/TRAF1/CCNE2/E2F2/CKS2/E2F3/CDK2/NFKB1/PIK3R1	2.6492921095747
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	18/943	101/9376	1.77197274340371	COL1A2/TGFB1/PRKCB/CDC42/STAT1/TNF/CDK4/BAX/FN1/PIM1/RAC1/COL1A1/IL1B/NFKB1/CXCL8/ICAM1/MAPK12/PIK3R1	2.60829151640138
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	22/943	133/9376	1.64466308932458	CALM3/GNG2/GNG5/CALM1/GNB2/PPP1CA/PRKCB/GNAS/GNGT2/ITPR2/GNAI2/ARRB2/PPP2CA/SCN1A/FOS/PRKACB/CREB3L2/PPP2R2B/PPP2R1A/GNB1/GNG10/MAPK12	2.50381699784715
Human Diseases	Substance dependence	hsa05032	Morphine addiction	16/943	91/9376	1.74817335368767	GNG2/GNG5/PDE4A/GNB2/PDE4B/PRKCB/GNAS/ADCY3/GNGT2/GNAI2/ARRB2/GRK5/PRKACB/PDE7A/GNB1/GNG10	2.39818351425066
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	9/943	41/9376	2.18255179370458	BRIP1/SEM1/RPA2/RPA3/BLM/RAD51/SSBP1/RPA1/BRCA2	2.53749603780546
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	13/943	69/9376	1.87326909185916	FCER1G/RAC2/LCP2/ALOX5AP/INPP5D/TNF/LAT/CSF2/MAP2K2/FYN/RAC1/MAPK12/PIK3R1	2.43454727351493
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	21/943	130/9376	1.60613426870055	GNG2/GNG5/GNB2/COL1A2/TGFB1/NFKBIA/GNAS/ADCY3/GNGT2/GNAI2/ARRB2/MAP2K2/FOS/COL1A1/PRKACB/CREB3L2/NFKB1/GNB1/GNG10/MAPK12/PIK3R1	2.32709441677541
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	14/943	77/9376	1.80777017256339	E2F1/TGFB1/NFKBIA/MYC/CDK4/BAX/GADD45B/MAP2K2/E2F2/E2F3/HDAC1/NFKB1/HDAC2/PIK3R1	2.37993713583043
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	19/943	115/9376	1.64271289593803	GNG2/GNG5/KCNQ5/GNB2/PRKCB/PIK3CG/ADCY3/GNGT2/ITPR2/GNAI2/PIK3R6/FYN/PIK3R5/FOS/PRKACB/CREB3L2/GNB1/GNG10/PIK3R1	2.31892886511325
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	9/943	42/9376	2.13058627480685	PCBP2/PCBP1/FTL/GPX4/VDAC2/VDAC3/PRNP/NCOA4/STEAP3	2.45552799723279
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	7/943	30/9376	2.31997172145635	TYMS/GGH/TNF/DHFR/SHMT2/IL1B/NFKB1	2.4213791617338
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	13/943	73/9376	1.77062421011345	CXCR4/BST2/PPIA/APOBEC3G/RAN/APOBEC3H/PSIP1/CHMP4A/PIN1/MX1/CCR5/MX2/APOBEC3C	2.2102581608683
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	13/943	73/9376	1.77062421011345	E2F1/RASSF5/PRKCB/CDK4/BAX/GADD45B/STK4/MAP2K2/E2F2/JAK3/E2F3/RASSF1/PIK3R1	2.2102581608683
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	25/943	168/9376	1.4795738019492	SLC25A5/PPIA/IFNG/TNFAIP3/FTL/FASLG/BID/SLC25A6/STAT1/IRF9/TNF/PYCARD/BAX/CHMP4A/HMGB1/VDAC2/PARP1/JAK3/HSP90AB1/VDAC3/IL1B/CHMP5/ZBP1/CHMP2A/CASP1	2.09738361290455
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	15/943	90/9376	1.6571226581831	CD247/LCK/IFNG/NFKBIA/CSNK2B/PRKCQ/ZAP70/STAT1/CD3E/LAT/MAP2K2/FOS/NFKB1/MAPK12/PIK3R1	2.09461298632332
Human Diseases	Cancer: specific types	hsa05214	Glioma	13/943	76/9376	1.70073114918792	CALM3/E2F1/CALM1/PRKCB/CDK4/CAMK1/BAX/GADD45B/MAP2K2/E2F2/E2F3/PDGFRB/PIK3R1	2.05100717486741
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	47/943	362/9376	1.29090770609844	IL2RG/GNG2/IL2RB/GNG5/GNB2/CCND2/COL1A2/SPP1/FASLG/PIK3AP1/RPS6/YWHAB/MYC/CDK4/PIK3CG/EIF4EBP1/GNGT2/FN1/RHEB/ITGB7/ITGA1/CCND3/CCNE2/PIK3R6/MAP2K2/PPP2CA/PIK3R5/CDC37/NR4A1/JAK3/RAC1/HSP90AB1/COL6A1/COL1A1/DDIT4/MCL1/CDK2/CREB3L2/NFKB1/PPP2R2B/PDGFRB/PPP2R1A/GNB1/YWHAQ/GNG10/OSM/PIK3R1	1.88756175209136
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	10/943	54/9376	1.84124739798123	BRIP1/UBE2T/CENPX/RPA2/RPA3/BLM/RAD51/FANCI/RPA1/BRCA2	2.07308208671246
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	18/943	116/9376	1.5428383369291	IDH2/GAPDH/ENO1/PGK1/TPI1/TALDO1/PKM/PRPS1/ECHS1/PGLS/SDHD/SHMT2/MDH2/PGP/PGAM1/MDH1/IDH3G/GPI	1.96718157005812
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	19/943	125/9376	1.51129586426299	FCER1G/RAC2/CTSD/PRKCB/RHOA/BID/TNF/BAX/GNAI2/MAP2K2/FYN/PPP2CA/S1PR4/RAC1/NFKB1/PPP2R2B/PPP2R1A/MAPK12/PIK3R1	1.92434696960126
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	15/943	93/9376	1.60366708856429	ACTB/RAC2/ACTG1/MYL12A/CSNK2B/CDC42/RHOA/MYL12B/WAS/FYN/RAC1/ACP1/YES1/SNAI2/RAP1B	1.95634404436966
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	15/943	94/9376	1.58660680038808	JUND/IFNG/TNFAIP3/NFKBIA/TNF/FOSB/CXCL3/CEBPB/CSF2/HSP90AB1/FOS/IL1B/NFKB1/CXCL8/MAPK12	1.91135198760204
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	17/943	110/9376	1.53660464667888	MAD2L1/CDK1/ANAPC11/PKMYT1/ADCY3/GNAI2/MAD2L2/CDC25B/BUB1/STK10/HSP90AB1/CDC25A/PRKACB/CDK2/SPDYE2/MAPK12/PIK3R1	1.89301937132881
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	8/943	41/9376	1.94004603884851	E2F1/MYC/CDK4/MAP2K2/E2F2/E2F3/RASSF1/CXCL8	2.01713202891537
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	7/943	34/9376	2.04703387187325	POLR2L/POLR2J/POLR2K/POLR2G/POLR3K/POLR2F/POLR2E	2.04517602472421
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	18/943	119/9376	1.50394325280483	JUNB/TNFRSF1B/TNFAIP3/CCL5/NFKBIA/IRF1/TNF/CXCL3/TRAF1/CEBPB/CSF2/FOS/IL1B/CREB3L2/NFKB1/ICAM1/MAPK12/PIK3R1	1.84999441853905
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	6/943	28/9376	2.13058627480685	GGH/AKR1B1/DHFR/AKR1C3/GCH1/PTS	2.00342831315847
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	33/943	250/9376	1.31244114528102	LAPTM5/CTSW/CTSC/CD63/CTSD/LAMTOR5/ATP6V1F/ATP6V0B/ATP6V0C/LITAF/VAMP8/BLOC1S1/ACP5/CD68/LAMTOR2/KXD1/LAMTOR1/NPC2/PSAP/AP2S1/LAMP1/TCIRG1/ATP6V1G1/OSBPL7/LAMTOR4/CLTB/CTSA/CTSL/CD164/CTSB/CTSZ/AP2M1/LAPTM4A	1.67435840899455
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	17/943	115/9376	1.46979574899719	JUND/PDE4A/PDE4B/PRKCB/RHOA/NACA/NR4A2/GNAS/ADCY3/GATA3/ITPR2/GNAI2/ARRB2/FOS/PRKACB/CREB3L2/ARHGEF1	1.69503821993034
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	10/943	59/9376	1.68520948289807	IDH2/RRM2/GSTO1/GSTP1/GPX4/SRM/LAP3/RRM1/PRDX6/SMS	1.76547575238023
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	14/943	91/9376	1.52965168447671	RAC2/IFITM1/NFKBIA/PRKCB/PIK3AP1/INPP5D/CARD11/MAP2K2/RAC1/FOS/FCGR2B/NFKB1/CD79B/PIK3R1	1.6977374718659
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	12/943	75/9376	1.59083775185578	IDH2/GAPDH/ENO1/PGK1/TPI1/TALDO1/PKM/PRPS1/SHMT2/PGAM1/IDH3G/MAT2A	1.7178470003931
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	28/943	212/9376	1.31319154044699	PFN1/ACTB/RAC2/ITGB2/CALM3/APBB1IP/RASSF5/LCP2/FYB1/CALM1/ACTG1/PRKCB/CDC42/RHOA/GNAS/ADCY3/LAT/GNAI2/MAP2K2/PRKD3/RAC1/ITGAM/PDGFRB/VASP/RAP1B/MAPK12/PIK3R1/EVL	1.5423603335705
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	11/943	69/9376	1.58507384695775	CALM3/CALM1/PPP1CA/PRKCB/GNAS/FOSB/FOS/PRKACB/HDAC1/CREB3L2/HDAC2	1.63110082813467
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	27/943	204/9376	1.31595034620423	ACTB/MSN/FLNA/CD63/ACTG1/PPP1CA/COL1A2/TGFB1/FASLG/PRKCB/CDC42/RHOA/RPS6/MYC/TNF/FN1/ITPR2/CD44/MAP2K2/RAC1/COL1A1/PRKACB/ARHGEF1/CTSL/MAPK12/PIK3R1/NUDT16L1	1.52564092716563
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	17/943	120/9376	1.40855425945564	ARHGDIB/CALM3/MATK/CALM1/FASLG/NFKBIA/CDC42/RHOA/BAX/ARHGDIA/MAP2K2/RAC1/NFKB1/SH2B3/RAP1B/MAPK12/PIK3R1	1.50618780555289
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	13/943	87/9376	1.48569617630209	RAC2/TGFB1/CYCS/RHOA/MYC/BAX/GADD45B/MAP2K2/MSH6/RAC1/FOS/BIRC5/PIK3R1	1.52191453134017
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	11/943	71/9376	1.54042387943781	IDH2/LDHB/SLC7A5/SLC1A5/PKM/MYC/MAP2K2/LDHA/PGAM1/PDGFRB/PIK3R1	1.52846659218366
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	14/943	97/9376	1.43503405450908	CALM3/GNG2/GNG5/CALM1/GNB2/PRKCB/GNAS/ADCY3/GNGT2/GNAI2/FOS/PRKACB/GNB1/GNG10	1.44015411302289
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	13/943	89/9376	1.45230974537396	GNG2/GNG5/GNB2/PRKCB/GABARAP/ADCY3/GNGT2/GNAI2/SLC38A1/PRKACB/GNB1/GABARAPL2/GNG10	1.43365171980052
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	19/943	140/9376	1.34937130737767	CALM3/GNG2/GNG5/CALM1/GNB2/SPP1/RPS6/PIK3CG/ADCY3/GNGT2/ITPR2/GNAI2/PIK3R6/MAP2K2/KLF2/PIK3R5/PRKACB/GNB1/GNG10	1.39270689330758
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	14/943	98/9376	1.42039084987123	CALM3/CALM1/PRKCB/NR4A2/GNAS/CAMK1/ADCY3/ITPR2/NR4A1/PRKD3/LDLR/POMC/PRKACB/CREB3L2	1.39890925322206
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	26/943	203/9376	1.27345386540179	ACTB/RAC2/FLNA/CCND2/ACTG1/PPP1CA/COL1A2/MYL12A/SPP1/PRKCB/CDC42/RHOA/MYL12B/FN1/PARVG/ITGB7/ITGA1/CCND3/FYN/RAC1/COL6A1/COL1A1/PDGFRB/VASP/RAP1B/PIK3R1	1.31712448522592
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	22/943	168/9376	1.3020249457153	IL2RG/IL2RB/IFNG/CCND2/IL27RA/IL21R/STAT1/MYC/IRF9/CSF2/CCND3/PIM1/IL10RA/JAK3/IL12RB2/MCL1/IL12RB1/PDGFRB/SOCS1/IL9R/OSM/PIK3R1	1.32088568903676
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	14/943	99/9376	1.4060434675493	CALM3/CALM1/PPP1CA/PTGER4/PRKCB/PRKCQ/GNAS/ADCY3/ITPR2/IL1B/PRKACB/PRKCH/MAPK12/PIK3R1	1.35811573623231
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	15/943	108/9376	1.38093554848592	SUMO2/RAN/EEF1A1/SAP18/SUMO3/ALYREF/RNPS1/RBM8A/SUMO1/MAGOH/NXT1/PNN/THOC6/KPNB1/UBE2I	1.33143755307398
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	15/943	110/9376	1.35582762942254	GAPDH/LDHB/IFNG/ENO1/PRKCB/PGK1/RPS6/ELOB/RBX1/EIF4EBP1/MAP2K2/LDHA/NFKB1/TIMP1/PIK3R1	1.25527909517708
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	15/943	110/9376	1.35582762942254	EMP3/IFNG/TGFB1/RHOA/MYC/RBX1/TNF/BMP8A/PPP2CA/ID2/HDAC1/TFDP1/PPP2R1A/SKP1/HDAC2	1.25527909517708
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	20/943	154/9376	1.29126440897385	ACTB/CALM3/CALM1/ACTG1/PPP1CA/PRKCB/RHOA/MYL6/GNAS/CAMK1/PIK3CG/ADCY3/ITPR2/GNAI2/PIK3R6/MAP2K2/RGS2/PIK3R5/FOS/PRKACB	1.21866869500986
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	36/943	298/9376	1.20113588646829	CCL4/XCL1/CCL3/CXCR4/XCL2/IL2RG/TNFRSF18/TNFRSF1B/IL2RB/IFNG/TGFB1/FASLG/CCL5/CXCR3/IL32/IL27RA/IL21R/TNF/CCL4L2/CXCL3/LTB/CSF2/RELT/BMP8A/IL10RA/IL12RB2/CCR5/IL1B/TNFSF14/IL12RB1/IL9R/CCL3L1/CCR9/CXCL8/OSM/TNFRSF4	1.17992130010951
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	10/943	68/9376	1.46216705133803	BCL2A1/MYC/EIF4EBP1/CSF2/PIM1/MAP2K2/CD14/ITGAM/NFKB1/PIK3R1	1.27901513635873
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	9/943	60/9376	1.49141039236479	RAC2/PRKCB/CDC42/SH2D2A/MAP2K2/RAC1/MAPKAPK3/MAPK12/PIK3R1	1.27689638187574
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	8/943	52/9376	1.52965168447671	APOE/APOC1/STARD3NL/VDAC2/NPC2/TSPO/VDAC3/LDLR	1.28068207688927
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	11/943	78/9376	1.40218071077032	ENO1/LSM7/BTG1/LSM5/LSM4/HSPA9/PABPC1/LSM3/LSM2/LSM1/LSM8	1.19268072907445
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	29/943	238/9376	1.21150984253723	RAC2/CALM3/GNG2/GNG5/RASSF5/CALM1/GNB2/FASLG/PRKCB/CDC42/RHOA/ETS1/ZAP70/RASAL3/GNGT2/LAT/STK4/MAP2K2/RAB5C/RAC1/ARF6/PRKACB/NFKB1/PDGFRB/RASSF1/GNB1/GNG10/RAP1B/PIK3R1	1.10520774073313
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	6/943	37/9376	1.61233555931329	IFNG/FASLG/PRKCB/TNF/IL1B/ICAM1	1.24793104562333
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	6/943	37/9376	1.61233555931329	MYC/BAX/GADD45B/MAP2K2/TPM3/NCOA4	1.24793104562333
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	12/943	88/9376	1.35582762942254	ITGB2/C1QA/CLU/C1QB/SERPINE2/C1QC/SERPING1/ITGAX/ITGAM/VSIG4/C4BPA/F5	1.12142526025649
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	8/943	54/9376	1.47299791838498	LDHB/SRM/DNMT1/LDHA/MDH2/SMS/MDH1/MAT2A	1.16560659089025
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	24/943	195/9376	1.22372134758137	ACTB/RAC2/ITGB2/SLC25A5/CYBA/ACTG1/PRKCB/SLC25A6/NCF1/HMGB1/VDAC2/FCGR3A/MAP2K2/RAC1/VDAC3/ITGAM/HDAC1/NFKB1/SELPLG/PPIF/CASP1/MAPK12/HDAC2/PIK3R1	1.0556748446747
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	5/943	30/9376	1.6571226581831	IDH2/SDHD/MDH2/MDH1/IDH3G	1.20543727215016
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	12/943	89/9376	1.34059361111442	PRKCB/TUBB/TUBA1B/CDK1/GNAS/ADCY3/ITPR2/GNAI2/MAP2K2/TUBA4A/PRKACB/PDGFRB	1.07955360529222
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	18/943	142/9376	1.26034681044912	UBC/UBA52/RPS27A/UBB/UBE2C/UBE2L6/ELOB/RBX1/ANAPC11/UBE2L3/UBE2S/STUB1/UBE2N/UBE2M/SOCS1/SKP1/UBE2I/HERC1	1.04532643408911
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	18/943	143/9376	1.25153319639004	HLA-DRA/HLA-DPA1/HLA-DRB5/IFNG/SNRPB/C1QA/HLA-DPB1/C1QB/HLA-DRB1/SNRPD3/HLA-DQA2/C1QC/TNF/HLA-DQA1/FCGR3A/HLA-DQB1/HLA-DMA/SNRPD1	1.01354338858831
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	35/943	300/9376	1.15998586072817	JUND/RAC2/DUSP2/FLNA/STMN1/TGFB1/FASLG/PTPN7/PRKCB/CDC42/DUSP1/HSPA8/MYC/TNF/GADD45B/ARRB2/STK4/MAP2K2/CD14/CDC25B/HSPA6/NR4A1/RAC1/MAP4K1/FOS/RELB/DUSP4/IL1B/PRKACB/MAPKAPK3/NFKB1/PDGFRB/NFKB2/RAP1B/MAPK12	0.941771232590927
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	10/943	75/9376	1.32569812654648	TOP2A/FASLG/CYCS/GSTO1/GSTP1/BID/BAX/MSH6/BIRC5/PIK3R1	0.946959716037405
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	20/943	166/9376	1.1979199938673	SLC25A5/CALM3/CALM1/PPP1CA/RHOA/SLC25A6/ATP2A3/PIK3CG/ADCY3/ITPR2/GNAI2/VDAC2/PIK3R6/MAP2K2/RGS2/PIK3R5/VDAC3/CREB3L2/VASP/PPIF	0.860328543965848
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	9/943	67/9376	1.33559139614758	GAPDH/LDHB/ENO1/PGK1/TPI1/PKM/LDHA/PGAM1/GPI	0.92182214820701
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	19/943	157/9376	1.20326103842595	DUSP2/C1QA/TGFB1/PTGER4/C1QB/ATP2A3/C1QC/CALR/HAVCR2/CEBPB/MAP2K2/RAB5C/SLC16A1/RAC1/PECAM1/DUSP4/UQCRFS1/CASP1/MAPK12	0.858840454530051
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	19/943	157/9376	1.20326103842595	ACTB/ITGB2/CCND2/ACTG1/PPP1CA/TGFB1/MOB1A/YWHAB/MYC/BMP8A/CCND3/PPP2CA/ID2/BIRC5/PPP2R2B/RASSF1/PPP2R1A/YWHAQ/SNAI2	0.858840454530051
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	10/943	76/9376	1.30825473014456	ACTB/CALM3/CALM1/ACTG1/PRKCB/GNAS/ADCY3/ITPR2/GNAI2/PRKACB	0.902247122803082
Cellular Processes	Cell motility	hsa04814	Motor proteins	23/943	194/9376	1.17877797334674	ACTB/ACTG1/MYL12A/TUBB/TUBA1B/MYL6/MYL12B/MYO1F/MYO1G/KIF15/DCTN3/CAPZA1/TUBA4A/KIF18A/TPM3/KIFC1/DYNLT1/DCTN6/KIF21B/KIF2C/KIF11/BICDL1/DYNLL1	0.841388680298772
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	17/943	139/9376	1.2160180657171	CALM3/CALM1/CTSD/HSPA8/GNAS/ADCY3/ITPR2/GNAI2/KRT10/MAP2K2/HSPA6/HSP90AB1/FOS/POMC/PRKACB/CREB3L2/PIK3R1	0.857990414044848
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	13/943	103/9376	1.25490842076002	PPP1CA/SAP18/ALYREF/RNPS1/RBM8A/PABPC1/PPP2CA/NUDT21/MAGOH/NXT1/PNN/PPP2R2B/PPP2R1A	0.8698474592177
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	20/943	169/9376	1.17665514190516	UBC/CTSD/UBA52/RPS27A/UBB/PRKCQ/GABARAP/VAMP8/RHEB/HMGB1/MAP2K2/PPP2CA/LAMP1/DDIT4/PRKACB/CTSL/GABARAPL2/RAB1A/CTSB/PIK3R1	0.774927366268537
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	13/943	105/9376	1.23100540322173	ACTB/ACTG1/TGFB1/SNTB1/ATP2A3/TNF/GNAS/ADCY3/ITGB7/ITGA1/TPM3/EMD/PRKACB	0.795983254881833
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	13/943	106/9376	1.21939214470077	E2F1/NFKBIA/GSTP1/CCNE2/MAP2K2/E2F2/HSP90AB1/E2F3/CDK2/CREB3L2/NFKB1/PDGFRB/PIK3R1	0.759599331123282
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	9/943	70/9376	1.27835176488411	TGFB1/CDC42/ETS1/ELOB/RBX1/MAP2K2/RAC1/RAP1B/PIK3R1	0.781649239359946
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	3/943	18/9376	1.6571226581831	CD320/PRDX1/MMADHC	0.933128832624974
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	6/943	44/9376	1.35582762942254	TMEM258/DAD1/MAN1A1/MAN2A1/KRTCAP2/STT3B	0.791095792854478
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	7/943	53/9376	1.31319154044699	RAB11A/PRKCB/GNAS/AP2S1/PRKACB/CLTB/AP2M1	0.764575803850414
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	8/943	62/9376	1.28293367085143	HSPA8/SOD1/ADCY3/HSPA6/PRKACB/HDAC1/HDAC2/PIK3R1	0.747416698749928
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	9/943	71/9376	1.26034681044912	CCND2/IRF1/STAT1/MAP2K2/FOS/NFKB1/SOCS1/MAPK12/PIK3R1	0.736332011396331
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	4/943	27/9376	1.47299791838498	ELOVL5/ACOT7/FADS1/FADS2	0.82301730337254
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	12/943	99/9376	1.20518011504226	E2F1/CDK4/GNAS/BAX/ADCY3/MAP2K2/E2F2/FOS/E2F3/PRKACB/MAPK12/PIK3R1	0.686277123685067
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	18/943	155/9376	1.15464030376629	E2F1/CDK4/GNAS/ADCY3/ITPR2/GNAI2/CCNE2/MAP2K2/E2F2/NR4A1/AIP/LDLR/E2F3/POMC/PRKACB/CDK2/CREB3L2/RAP1B	0.649157331915108
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	9/943	72/9376	1.24284199363733	ISG15/RNF125/NFKBIA/TNF/IRF7/PIN1/NFKB1/CXCL8/MAPK12	0.691680642115262
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	15/943	128/9376	1.16516436903499	RRM2/PDE4A/PDE4B/GUK1/NME2/APRT/ADCY3/DCK/PRPS1/RRM1/ADA/PDE7A/PAICS/NME1/NT5C	0.629140830476551
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	10/943	82/9376	1.21252877428032	RRM2/UPP1/DUT/GSTO1/TK1/GSTP1/NME2/UCK2/RRM1/NME1	0.646358945936292
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	4/943	28/9376	1.42039084987123	ELOVL5/ACOT7/ACAA2/ECHS1	0.744943530619692
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	4/943	28/9376	1.42039084987123	ATP6V1F/ATP6V0C/TCIRG1/ATP6V1G1	0.744943530619692
Human Diseases	Cancer: specific types	hsa05218	Melanoma	9/943	73/9376	1.22581676084778	E2F1/CDK4/BAX/GADD45B/MAP2K2/E2F2/E2F3/PDGFRB/PIK3R1	0.647674095849077
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	10/943	83/9376	1.1979199938673	PHF19/CSNK2B/SFMBT2/AUTS2/CBX3/HDAC1/TFDP1/SKP1/AURKB/HDAC2	0.60562135540923
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	8/943	65/9376	1.22372134758137	GNAS/ADCY3/ITPR2/NR4A1/LDLR/POMC/PRKACB/CREB3L2	0.605224326800041
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	14/943	122/9376	1.14096969907689	JUNB/PRKCB/STAT1/GNAS/ADCY3/ITPR2/GNAI2/MAP2K2/FOS/PRKACB/CREB3L2/SOCS1/MAPK12/PIK3R1	0.52407250428315
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/943	12/9376	1.6571226581831	NCAM1/FCGR2B	0.761652369006801
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	5/943	39/9376	1.27470973706393	TYMS/MTHFD2/DHFR/SHMT2/MAT2A	0.574848115195597
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	3/943	21/9376	1.42039084987123	CHST12/XYLT1/CHST11	0.644898609541573
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	8/943	67/9376	1.18719235213118	CALM3/CALM1/PPP1CA/PRKCB/ITPR2/MAP2K2/PRKACB/RAP1B	0.514190942170651
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	12/943	105/9376	1.13631267989699	UBC/E2F1/UBA52/RPS27A/CSNK2B/UBB/GABARAP/VCP/RAB5C/TOMM7/PHB2/GABARAPL2	0.469697284621174
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	6/943	49/9376	1.2174778713182	GNAS/FOSB/GNAI2/PRKACB/CREB3L2/NFKB1	0.510378721304612
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	17/943	154/9376	1.09757474762777	CALM3/CALM1/PPP1CA/ATP2A3/GNAS/PIK3CG/ADCY3/GNAI2/PIK3R6/PPP2CA/PIK3R5/TPM3/PRKACB/CREB3L2/PPP2R2B/PPP2R1A/MAPK12	0.408258910782774
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	4/943	31/9376	1.28293367085143	TALDO1/PRPS1/PGLS/GPI	0.527626090443309
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	4/943	31/9376	1.28293367085143	SHMT2/MDH2/PGP/MDH1	0.527626090443309
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	2/943	13/9376	1.52965168447671	XRCC6/FEN1	0.639006030417232
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	13/943	116/9376	1.11427213222657	GNG2/GNG5/GNB2/PRKCB/GNAS/ADCY3/GNGT2/ITPR2/GNAI2/SLC38A1/PRKACB/GNB1/GNG10	0.414108616128772
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	12/943	107/9376	1.11507319055312	LDHB/CALM3/CALM1/PRMT1/PKM/GNAS/ITPR2/PPP4C/LDHA/PRKACB/CREB3L2/PGAM1	0.400313316103705
Organismal Systems	Endocrine system	hsa04924	Renin secretion	8/943	69/9376	1.15278097960564	CALM3/CALM1/PTGER4/GNAS/ITPR2/GNAI2/PRKACB/CTSB	0.42593116006427
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	9/943	79/9376	1.13271675369478	ATP6V1F/ATP6V0B/ATP6V0C/AP2S1/TCIRG1/ATP6V1G1/CLTB/VAMP2/AP2M1	0.396112287650363
Organismal Systems	Nervous system	hsa04730	Long-term depression	7/943	60/9376	1.15998586072817	PRKCB/GNAS/ITPR2/GNAI2/MAP2K2/PPP2CA/PPP2R1A	0.415712345300646
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	4/943	32/9376	1.24284199363733	CYCS/BID/BAX/BIRC5	0.460132382313144
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/943	14/9376	1.42039084987123	B3GNT7/ST3GAL1	0.526360618482994
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	17/943	158/9376	1.06978804515618	SLC7A5/PRKCB/RHOA/RPS6/LAMTOR5/ATP6V1F/TNF/EIF4EBP1/RHEB/LAMTOR2/MAP2K2/LAMTOR1/ATP6V1G1/PRR5L/DDIT4/LAMTOR4/PIK3R1	0.295829622543347
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	4/943	33/9376	1.20518011504226	VAMP8/STX11/VAMP5/VAMP2	0.394820322487842
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	18/943	170/9376	1.05276027696338	ACTB/E2F1/ACTG1/TGFB1/GSTO1/PRKCB/GSTP1/MYC/CDK4/BAX/GADD45B/NQO1/DPF3/MAP2K2/E2F2/E2F3/ACTL6A/PIK3R1	0.232138127258874
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	13/943	122/9376	1.05947186342854	ACTB/ACTG1/PRKCB/STAT1/ATP2A3/MYC/RHEB/MAP2K2/PRKACB/HDAC1/MED30/HDAC2/PIK3R1	0.221094097564762
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	21/943	201/9376	1.03879330811478	GZMB/IL2RB/CCND2/FLI1/BCL2A1/HPGD/MYC/BCL11B/BAX/GADD45B/TRAF1/CEBPB/CSF2/ITGB7/CD14/ID2/ITGAM/HDAC1/NFKB1/CXCL8/HDAC2	0.18590978236655
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	10/943	93/9376	1.0691113923762	CALM3/CALM1/PRKCB/CDC42/GNAS/ADCY3/ITPR2/MAP2K2/PRKACB/MAPK12	0.223973881357068
Organismal Systems	Digestive system	hsa04970	Salivary secretion	10/943	93/9376	1.0691113923762	CALM3/CALM1/PRKCB/LYZ/GNAS/CST3/ADCY3/ITPR2/PRKACB/VAMP2	0.223973881357068
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	14/943	133/9376	1.04660378411564	CCND2/TGFB1/FASLG/PRMT1/GABARAP/GADD45B/STK4/MAP2K2/KLF2/S1PR4/CDK2/GABARAPL2/MAPK12/PIK3R1	0.181005161866802
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	14/943	134/9376	1.03879330811478	CALM3/CALM1/PPP1CA/PRKCB/RHOA/PRKCQ/MYL6/GNAS/ADCY3/ITPR2/MAP2K2/PRKACB/ARHGEF1/PRKCH	0.151243481989019
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	12/943	115/9376	1.03750288164507	GNG2/GNG5/GNB2/PRKCB/DUSP1/GNAS/GNGT2/ITPR2/GNAI2/PRKACB/GNB1/GNG10	0.135311606973064
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	4/943	36/9376	1.10474843878874	AKR1B1/UGDH/UGP2/DCXR	0.210559967774792
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	6/943	56/9376	1.06529313740342	TMEM258/DAD1/MAN1A1/MAN2A1/KRTCAP2/STT3B	0.163871726431237
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	5/943	47/9376	1.05773786692539	LDHB/PKM/LDHA/MDH2/MDH1	0.132691331494215
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	22/943	217/9376	1.00801931281184	E2F1/CDC6/GSTO1/PRKCB/MYC/GNAS/EIF4EBP1/ADCY3/GNAI2/CCND3/ARRB2/MAP2K2/HSP90AB1/FOS/AIP/CDC25A/PRKACB/KPNB1/BIRC5/CREB3L2/NFKB1/PIK3R1	0.0399662523563783
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	4/943	37/9376	1.07489037287553	UGDH/UGP2/GALK1/GPI	0.152625500688685
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	15/943	149/9376	1.00094657205691	FCER1G/RHOA/GNAS/PIK3CG/ARF1/ADCY3/RHEB/PIK3R6/MAP2K2/FYN/PIK3R5/ARF6/PDGFRB/CXCL8/PIK3R1	0.00389463702408116
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	4/943	38/9376	1.04660378411564	UGDH/UGP2/GALK1/GPI	0.0962579214999549
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	10/943	99/9376	1.00431676253521	RAC2/PRKCB/WAS/EIF4EBP1/RHEB/MAP2K2/RAC1/FOS/PDGFRB/PIK3R1	0.0144385111378271
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	10/943	99/9376	1.00431676253521	ACTB/ACTG1/TGFB1/SNTB1/ATP2A3/TNF/ITGB7/ITGA1/TPM3/EMD	0.0144385111378271
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/943	29/9376	1.02855889128606	CALM3/CALM1/GNB1	0.0515056242555543
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	10/943	101/9376	0.984429301890953	CALM3/CALM1/PRKCB/GNAS/ADCY3/GNAI2/MAP2K2/POMC/PRKACB/CREB3L2	-0.0526092664919857
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	10/943	102/9376	0.974778034225355	RAB11A/PRKCB/RHOA/SLC4A4/ATP2A3/GNAS/ADCY3/ITPR2/RAC1/RAP1B	-0.0856437956456625
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	15/943	154/9376	0.968448306730385	MTHFD2/NME2/CTPS1/GGH/DHRS3/DHFR/NQO1/UGDH/PDXK/SHMT2/GCH1/NME1/UGP2/MAT2A/PTS	-0.132014278701953
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	5/943	52/9376	0.956032302797944	GNAS/ADCY3/AKR1C3/LDLR/PRKACB	-0.106312588856201
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/943	20/9376	0.994273594909862	UGDH/UGP2	-0.00857239931175788
NA	NA	hsa04981	Folate transport and metabolism	3/943	31/9376	0.962200253138576	TYMS/DHFR/SHMT2	-0.0704904884463616
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	3/943	32/9376	0.932131495227996	AKR1B1/UGP2/GALK1	-0.128595949642102
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	3/943	32/9376	0.932131495227996	LDHB/ECHS1/LDHA	-0.128595949642102
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	3/943	32/9376	0.932131495227996	GABARAP/PPP2CA/GABARAPL2	-0.128595949642102
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	6/943	65/9376	0.917791010686027	SPP1/PRKCB/ITPR2/ARRB2/MAP2K2/PIK3R1	-0.222396658845286
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	3/943	34/9376	0.87730023080282	BHLHE40/RBX1/SKP1	-0.239670017315015
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	21/943	226/9376	0.923882543942792	RAC2/CALM3/CALM1/PDE4A/PPP1CA/PDE4B/NFKBIA/RHOA/ATP2A3/GNAS/ADCY3/GNAI2/MAP2K2/RAC1/FOS/POMC/PRKACB/CREB3L2/NFKB1/RAP1B/PIK3R1	-0.387327535156704
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	8/943	89/9376	0.893729074076281	COL1A2/SPP1/FN1/CD44/ITGB7/ITGA1/COL6A1/COL1A1	-0.336838852740993
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/943	23/9376	0.864585734704228	ATP6AP2/CTSA	-0.217421908203333
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/943	23/9376	0.864585734704228	SLC4A4/MDH1	-0.217421908203333
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	5/943	57/9376	0.87216982009637	ELOVL5/ACAA2/FADS1/ECHS1/FADS2	-0.323695458710598
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	8/943	90/9376	0.883798751030989	BAX/EIF4EBP1/ADCY3/RHEB/PRKACB/CREB3L2/NFKB1/PIK3R1	-0.370397584205138
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	13/943	144/9376	0.897608106515848	C1QA/FASLG/NFKBIA/C1QB/C1QC/TNF/CXCL3/CD14/IL1B/NFKB1/SREBF1/CXCL8/MAPK12	-0.414046727842407
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	7/943	80/9376	0.869989395546129	PRKCB/RPS6/BAX/EIF4EBP1/MAP2K2/PDGFRB/PIK3R1	-0.390504594380917
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	4/943	47/9376	0.846190293540308	PKM/TNF/SOCS1/PIK3R1	-0.353480581006669
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	3/943	36/9376	0.828561329091552	GYG1/UGP2/GPI	-0.344617270092601
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	6/943	70/9376	0.852234509922739	TNFRSF1B/NFKBIA/PRKCQ/TNF/POMC/NFKB1	-0.414945394618315
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/943	12/9376	0.828561329091552	NQO1	-0.198709735862452
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	5/943	59/9376	0.842604741449036	GNAS/ADCY3/GNAI2/PRKACB/PIK3R1	-0.405536583259283
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	5/943	59/9376	0.842604741449036	MYC/BAX/GADD45B/MAP2K2/PIK3R1	-0.405536583259283
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	4/943	48/9376	0.828561329091552	OXCT1/ACAA2/ECHS1/HSD17B10	-0.398185623286557
NA	NA	hsa03272	Virion - Hepatitis viruses	4/943	48/9376	0.828561329091552	CD63/CHMP4A/LAMP1/LDLR	-0.398185623286557
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	4/943	50/9376	0.79541887592789	SRM/LAP3/SMS/GAMT	-0.485012901943057
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	29/943	323/9376	0.892691462922167	VIM/E2F1/ZEB2/CCND2/STMN1/PRKCB/RHOA/MYC/DNMT1/CD44/CCNE2/PIM1/CDCA5/MAP2K2/E2F2/CDC25B/CDC25A/E2F3/DDIT4/MCL1/HDAC1/NFKB1/PDGFRB/SOCS1/RASSF1/SPRY2/UBE2I/HDAC2/PIK3R1	-0.656280816313397
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/943	27/9376	0.73649895919249	OXCT1/ECHS1	-0.458492326523821
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	7/943	86/9376	0.809292460973144	ACTB/ACTG1/SNTB1/ATP2A3/ITGB7/ITGA1/EMD	-0.594100153915873
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	6/943	75/9376	0.79541887592789	PRKCB/GNAS/ADCY3/ITPR2/PRKACB/CREB3L2	-0.594814852673983
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	9/943	109/9376	0.820959849008143	PPP1CA/NFKBIA/PRKCB/PRKCQ/TNF/CREB3L2/NFKB1/SREBF1/PIK3R1	-0.628701559043174
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	3/943	41/9376	0.727517264568192	SHMT2/PGAM1/GAMT	-0.584688015535105
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/943	15/9376	0.662849063273241	ST3GAL1	-0.436977737717031
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/943	15/9376	0.662849063273241	ACP1	-0.436977737717031
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/943	29/9376	0.685705927524043	MOB1A/RASSF1	-0.566825660021111
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	20/943	233/9376	0.853453729536362	VIM/ACTB/FMNL1/LMNB1/ACTG1/COL1A2/ENO1/SNTB1/FN1/PDLIM2/FMNL3/DIAPH3/ITGB7/ITGA1/CAPZA1/TPM3/COL6A1/COL1A1/EMD/FBLN2	-0.757458433478306
NA	NA	hsa04519	Cadherin signaling	36/943	404/9376	0.885986371701857	VIM/ACTB/RAC2/KRT81/ARPC2/ARPC3/ARPC1B/ACTG1/PPP1CA/NCKAP1L/MOB1A/NFKBIA/BRK1/CDC42/RHOA/TMC8/YWHAB/KRT86/TMC6/MYO1F/ARPC4/MYO1G/ACTR2/KRT10/MAP2K2/ACTR3/CYFIP2/RAC1/ARPC5L/ARPC5/NFKB1/PDGFRB/VASP/YWHAQ/MAPK12/EVL	-0.783345316359702
Human Diseases	Substance dependence	hsa05034	Alcoholism	16/943	191/9376	0.83289934652135	CALM3/GNG2/GNG5/CALM1/GNB2/PPP1CA/GNAS/GNGT2/FOSB/GNAI2/PRKACB/HDAC1/CREB3L2/GNB1/GNG10/HDAC2	-0.780199532951064
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/943	16/9376	0.621420996818664	MIF	-0.506791152876778
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/943	16/9376	0.621420996818664	ST3GAL1	-0.506791152876778
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	3/943	43/9376	0.693679252262694	ACAA2/ECHS1/ECI1	-0.673209820642735
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	12/943	148/9376	0.806167779656645	E2F1/MYC/CDK4/BAX/GADD45B/MAP2K2/E2F2/FOS/E2F3/NFKB2/BRCA2/PIK3R1	-0.794791968416241
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	11/943	138/9376	0.792536923478875	CALM3/CALM1/PPP1CA/RPS6/EIF4EBP1/RHEB/MAP2K2/PRKACB/SREBF1/SOCS1/PIK3R1	-0.82099745813856
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/943	17/9376	0.584866820535213	LAMP1	-0.572858837241937
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	2/943	33/9376	0.602590057521129	IDH2/IDH3G	-0.764720897135025
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	6/943	86/9376	0.693679252262694	PRKCB/GNAS/ADCY3/PRKACB/CREB3L2/VAMP2	-0.954263288735169
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/943	35/9376	0.568156339948493	TPI1/AKR1B1	-0.855882839020757
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/943	20/9376	0.497136797454931	EBP	-0.752783658080677
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	4/943	62/9376	0.641466835425717	MFNG/HDAC1/LFNG/HDAC2	-0.947125428557368
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	3/943	49/9376	0.608738935659099	MFNG/LFNG/GALNT2	-0.918214439493091
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/943	36/9376	0.552374219394368	ST3GAL1/GALNT2	-0.899794507959994
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	4/943	63/9376	0.631284822164992	GPX4/HPGD/PTGDS/AKR1C3	-0.981899237961013
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	14/943	184/9376	0.756512517866199	RAC2/CXCR4/CFL1/MYL12A/CDC42/RHOA/MYL12B/GNAI2/FYN/RAC1/SEMA4D/PLXNA4/TRPC3/PIK3R1	-1.11540086461371
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	11/943	150/9376	0.729133969600566	E2F1/TGFB1/MYC/BAX/GADD45B/CCNE2/MAP2K2/E2F2/E2F3/CDK2/PIK3R1	-1.11826281018901
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/943	38/9376	0.523301892057822	PRKCB/PIK3R1	-0.984597494049239
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/943	23/9376	0.432292867352114	IDI1	-0.911513774500387
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	8/943	117/9376	0.679845193100761	ACTB/ACTG1/CDK2AP2/DPF3/HDAC1/POLE3/ACTL6A/HDAC2	-1.16525600599932
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/943	24/9376	0.414280664545776	XYLT1	-0.960712335696011
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	3/943	56/9376	0.532646568701712	CCND2/ARRB2/PRKACB	-1.17295655693821
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	8/943	122/9376	0.651982685186795	EIF4EBP1/RHEB/PPP2CA/CREB3L2/PPP2R2B/SREBF1/PPP2R1A/PIK3R1	-1.29379793602718
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/943	26/9376	0.382412921119178	FADS2	-1.05445852932318
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	6/943	98/9376	0.608738935659099	CALM3/CALM1/PRKCB/INPP5D/ITPR2/PIK3R1	-1.30197582440163
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	5/943	86/9376	0.578066043552245	PRKCB/MYC/EIF4EBP1/MAP2K2/PIK3R1	-1.31442642355446
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	2/943	44/9376	0.451942543140846	GTF2A2/TAF10	-1.21847184567264
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	4/943	76/9376	0.523301892057822	FABP5/UBC/DBI/FADS2	-1.39527298132557
Organismal Systems	Digestive system	hsa04976	Bile secretion	5/943	90/9376	0.552374219394368	SLC4A4/GNAS/ADCY3/LDLR/PRKACB	-1.42683068586019
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	18/943	254/9376	0.704603334975493	CXCR4/SLC25A5/CALM3/CALM1/PRKCB/SLC25A6/ATP2A3/GNAS/CAMK1/ADCY3/ITPR2/VDAC2/CYSLTR1/VDAC3/PRKACB/CYSLTR2/PDGFRB/PPIF	-1.59598147717463
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/943	48/9376	0.414280664545776	PRKCB/PIK3R1	-1.36039912945531
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/943	31/9376	0.320733417712859	UGDH	-1.2667236462257
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/943	31/9376	0.320733417712859	ECHS1	-1.2667236462257
NA	NA	hsa04082	Neuroactive ligand signaling	13/943	199/9376	0.649525464011468	GNG2/GNG5/GNB2/PRKCB/GNAS/ADCY3/GNGT2/GNAI2/P2RY14/POMC/PRKACB/GNB1/GNG10	-1.67102549566001
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	4/943	83/9376	0.479167997546922	IDH2/SOD1/PXMP2/PRDX1	-1.59370954446177
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	11/943	178/9376	0.614438738427443	RAC2/CCND2/CSNK2B/PRKCB/RHOA/MYC/RBX1/CCND3/RAC1/PRKACB/SKP1	-1.73662930603423
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/943	37/9376	0.268722593218882	MIF	-1.49033281671328
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	5/943	103/9376	0.4826570849077	COL1A2/SLC1A5/COL6A1/COL1A1/COL23A1	-1.76537683178764
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/943	38/9376	0.261650946028911	NT5C	-1.52502520182384
Organismal Systems	Digestive system	hsa04978	Mineral absorption	2/943	61/9376	0.325991342593397	FTL/MT2A	-1.76599470554056
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	3/943	78/9376	0.382412921119178	TPI1/INPP5D/PIK3CG	-1.83147572168671
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/943	42/9376	0.236731808311872	ECHS1	-1.65774736156923
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3/943	79/9376	0.377572251231593	GSTO1/GSTP1/AKR7A2	-1.85772536321024
NA	NA	hsa04081	Hormone signaling	13/943	219/9376	0.590208070037818	GNG2/GNG5/GNB2/RHOA/GNAS/ADCY3/GNGT2/GNAI2/POMC/PRKACB/GNB1/GNG10/PIK3R1	-2.05191462215633
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/943	63/9376	0.315642411082496	BAX/GADD45B	-1.8224641551144
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/943	45/9376	0.220949687757747	TAP1	-1.75169343590416
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/943	46/9376	0.216146433676057	FTL	-1.78206469757378
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/943	70/9376	0.284078169974246	GSTO1/GSTP1	-2.01040490658933
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/943	73/9376	0.272403724632839	GSTO1/GSTP1	-2.08684801793456
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	1/943	55/9376	0.180777017256339	PSAP	-2.03752362376376
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	6/943	144/9376	0.414280664545776	MYC/MAP2K2/ID2/JAK3/MAPK12/PIK3R1	-2.36849975155881
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/943	63/9376	0.157821205541248	ECHS1	-2.24274661369109
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/943	65/9376	0.152965168447671	AKR1B1	-2.29144912295861
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/943	66/9376	0.150647514380282	AKR1C3	-2.3154506212456
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/943	68/9376	0.146216705133803	DHRS3	-2.36278582417896
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	7/943	183/9376	0.38032323302563	RAN/CSNK2B/SNU13/NOP10/NHP2/FBL/NXT1	-2.8308220059845
NA	NA	hsa04382	Cornified envelope formation	9/943	217/9376	0.41237153705939	S100A4/KRT81/KRT86/KRT10/PPP2CA/S100A6/PPP2R2B/PPP2R1A/S100A10	-2.92859350828607
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/943	86/9376	0.115613208710449	PRKACB	-2.75507896283165
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	1/943	104/9376	0.0956032302797944	PTDSS1	-3.1012686933465
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	13/943	370/9376	0.349339371184546	GZMA/PTGER4/P2RY10/UTS2/TMEM97/NR3C1/P2RY8/CYSLTR1/S1PR4/TSPO/P2RY14/POMC/CYSLTR2	-4.27011777630243
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	7/943	449/9376	0.155009246422473	CALM3/CALM1/ADCY3/ARRB2/RGS2/PRKACB/GNB1	-6.13582259220385