category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	41/764	227/9376	2.2165740249556	AKAP13/CREB3L2/CCL4/CCL3/B2M/ADCY3/GNAQ/GNB2/PDGFRA/ARHGEF1/PPP3CA/CCL3L1/CCL4L2/PRKCA/PTK2/HLA-C/PIK3R1/PPP3R1/RPS6KB1/TSC2/PLCB1/GNB1/MTOR/ARHGEF11/AKT3/CHUK/TAP2/CCL5/AKT2/CXCR4/NFATC4/IL1R1/GRB2/ADCY1/TBK1/MDM2/MAP2K1/ITPR2/IKBKB/GNB4/CASP8	5.52643366331839
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	53/764	333/9376	1.9532411993145	COL6A1/COL1A1/COL1A2/FOXO1/COL6A3/CREB3L2/ISG15/PDGFRB/MX1/STAT1/ITGB8/TCF7L2/LAMA2/PARD3/MAML2/TYK2/JAG1/PTK2/CSNK1A1/HLA-C/PIK3R1/PPP2R1A/ATP6V1C1/RPS6KB1/TSC2/TCIRG1/MTOR/EIF2AK2/HES4/ATP6V1E1/IRF9/AKT3/CHUK/THBS3/FZD1/DVL3/PPP2R2D/AKT2/FZD3/APC/GRB2/ITGA9/PPP2R5D/TCF7/TBK1/TUBG2/TNC/MDM2/MAP2K1/CHD4/CREBBP/IKBKB/CASP8	5.27532186624368
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	22/764	99/9376	2.72716695753345	PDGFRB/PLPP3/PDGFRA/DGKB/PRKCA/PIK3R1/RPS6KB1/TSC2/MTOR/MAPK10/AKT3/FOS/PIP5K1A/MAPK9/AKT2/PIP5K1C/WASF1/GRB2/DGKE/PCYT1A/MAP2K1/SLC44A1	5.14551024000799
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	36/764	214/9376	2.06449087439448	BST2/B2M/GNAQ/GNB2/PPP3CA/PRKCA/PTK2/HLA-C/PIK3R1/AP1B1/PPP3R1/RPS6KB1/APOBEC3C/GNB1/MTOR/MAP2K7/MAPK10/AKT3/CHUK/TAP2/PAK1/FOS/MAPK9/AKT2/CXCR4/NFATC4/PAK3/CD247/LIMK1/TBK1/MAP2K1/ITPR2/AP1G1/IKBKB/GNB4/CASP8	4.69174060011185
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	22/764	108/9376	2.49990304440566	TMEM33/AAAS/NUP85/NUP37/NUP35/DDX19A/NCBP1/KPNB1/NUP155/XPOT/XPO5/NXT1/NDC1/NUP133/SEH1L/NUP62/NUP43/POM121C/TNPO3/NXT2/NUP88/SENP2	4.66941375949732
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	31/764	180/9376	2.11355439208842	BST2/OAS2/B2M/STAT1/OAS1/EIF2B5/OAS3/SRSF7/TYK2/HLA-C/PIK3R1/BIRC3/TSC2/MTOR/EIF2AK2/EIF2B3/IRF9/AKT3/CD74/CHUK/TAP2/EIF2B4/CCL5/JAK2/HLA-DMB/AKT2/HLA-DRA/TBK1/IFIH1/IKBKB/CASP8	4.49291821715868
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	22/764	109/9376	2.47696815409001	CCL4/CCL3/STAT1/CCL3L1/TYK2/CCL4L2/PIK3R1/TOLLIP/MAP3K8/MAP2K7/MAPK10/IRF9/AKT3/CHUK/FOS/CCL5/MAPK9/AKT2/TBK1/MAP2K1/IKBKB/CASP8	4.61950142769315
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	23/764	122/9376	2.31362114839928	FOXO1/CREB3L2/INSR/STK11/PIK3R1/PPP2R1A/RPS6KB1/CPT1A/TSC2/RPTOR/MTOR/PFKL/PFKFB3/STRADA/AKT3/PPP2R2D/PRKAG2/AKT2/SCD5/PPP2R5D/PRKAA1/CAMKK2/SIRT1	4.34976311611881
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	38/764	250/9376	1.86538219895288	PSAP/MITF/CTSL/OSTM1/AP3D1/VAMP7/GLB1/GGA1/AP1B1/ATP6V1C1/SMPD1/TTI1/RPTOR/AP3S2/GGA2/TCIRG1/TMEM175/MTOR/LIPA/AP4S1/AP5Z1/BORCS5/ATP6V1E1/AP3M1/VPS39/VPS26B/SLC15A4/SGSH/TPCN2/PLEKHM1/AP2A2/VPS33A/GGA3/AP4E1/NAGA/ENTPD4/DMXL1/AP1G1	4.13064656426988
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	22/764	119/9376	2.2688195697127	CREB3L2/IL15/JAG1/PIK3R1/BIRC3/MAP3K8/BAG4/ITCH/MAP2K7/MAPK10/AKT3/CHUK/FOS/CCL5/DNM1L/MAPK9/AKT2/BCL3/MAP2K1/PGAM5/IKBKB/CASP8	4.14876202436576
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	31/764	196/9376	1.94101933967304	STAT1/GNB2/TCF7L2/PPP3CA/TYK2/HLA-C/PIK3R1/PPP3R1/GNB1/MTOR/EIF2AK2/MAP2K7/MAPK10/IRF9/AKT3/CHUK/FOS/JAK2/MAPK9/AKT2/NFATC4/TCF7/TBK1/ANGPT2/MAP2K1/ITPR2/FGF2/CREBBP/IKBKB/GNB4/CASP8	3.96538674961547
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	34/764	224/9376	1.86275243081526	CREB3L2/IL15/B2M/ADCY3/TCF3/MAP3K1/PPP3CA/MSX1/CANX/HLA-C/PIK3R1/PPP3R1/ANAPC1/KAT2A/MAPK10/AKT3/CHUK/GPS2/FOS/ETS1/HLA-DMB/MAPK9/AKT2/NFATC4/IL1R1/IL2RB/POLB/SRF/ELK4/HLA-DRA/ADCY1/MAP2K1/CREBBP/IKBKB	3.89253478222759
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	18/764	90/9376	2.4544502617801	FOXO1/CREB3L2/ADCY3/INSR/STK11/PIK3R1/RPS6KB1/TSC2/RPTOR/MTOR/ATG13/AKT3/PRKAG2/AKT2/ADCY1/PRKAA1/CAMKK2/SIRT1	4.1293918483272
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	22/764	122/9376	2.21302892455583	CREB3L2/STAT1/ADCY3/GNAQ/MAP3K1/CACNA1D/PRKCA/PTK2/PIK3R1/PLCB1/MTOR/MAPK10/AKT3/FOS/JAK2/MAPK9/AKT2/GRB2/ADCY1/MAP2K1/ITPR2/CREBBP	4.01667442797172
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	17/764	83/9376	2.51359364158203	AUTS2/RYBP/KDM2A/EED/UBE2D3/TEX10/RNF2/PHF1/E2F6/MTF2/USP45/RING1/FBRS/BAP1/SCML2/WDR5/CREBBP	4.12525385842407
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	14/764	62/9376	2.77115352136463	FOXO1/ADCY3/INSR/PIK3R1/RPS6KB1/RPTOR/EIF4EBP2/MTOR/AKT3/PRKAG2/AKT2/ADCY1/PRKAA1/SIRT1	4.1673909261652
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	26/764	158/9376	2.01948439260388	INSR/PRKCA/STK11/PIK3R1/ATP6V1C1/RPS6KB1/TTI1/TSC2/SKP2/RPTOR/MTOR/STRADA/ATP6V1E1/AKT3/CHUK/FZD1/DVL3/AKT2/FZD3/GRB2/SEH1L/ULK2/PRKAA1/MAP2K1/LRP6/IKBKB	3.84920534336956
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	30/764	193/9376	1.90760383039905	CCL4/CCL3/STAT1/ADCY3/GNAQ/GNB2/XCL2/XCL1/CCL3L1/PARD3/CCL4L2/PTK2/PIK3R1/PLCB1/GNB1/AKT3/CHUK/PAK1/CCL5/JAK2/ELMO1/AKT2/CXCR4/GRB2/ADCY1/ARRB1/GRK3/MAP2K1/IKBKB/GNB4	3.79457367404146
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	14/764	63/9376	2.72716695753345	KMT2C/GCDH/PLOD3/COLGALT1/SETDB1/SETMAR/SETDB2/DOT1L/AASS/AADAT/SMYD3/ASH1L/KMT5C/SUV39H2	4.09675602481645
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	28/764	178/9376	1.9304664980293	DKK1/APCDD1/TBL1X/TLE1/MCC/TCF7L2/PPP3CA/SFRP4/PRKCA/CSNK1A1/PPP3R1/PLCB1/MAPK10/CTBP1/FZD1/DVL3/ROR2/MAPK9/FZD3/NFATC4/APC/PRICKLE2/SIRT1/TCF7/LRP6/CREBBP/SENP2/LZTS2	3.73288272632036
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	23/764	138/9376	2.04537521815009	FOXO1/INSR/PIK3R1/RPS6KB1/TSC2/RPTOR/MTOR/MAPK10/AKT3/HK1/PRKAG2/MAPK9/AKT2/GRB2/PYGB/PTPRF/MKNK1/INPPL1/PRKAA1/RAPGEF1/MAP2K1/PDE3B/IKBKB	3.6847079517512
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	22/764	130/9376	2.07684252919855	COL3A1/COL1A1/COL1A2/CREB3L2/ADCY3/GNB2/PRKCA/PIK3R1/PLCB1/GNB1/MMP2/MAP2K7/MAPK10/AKT3/FOS/MAPK9/AKT2/GRB2/ADCY1/ARRB1/MAP2K1/GNB4	3.68236842441745
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	21/764	122/9376	2.11243670071239	PTPRC/PPP3CA/PIK3R1/PPP2R1A/PPP3R1/MAP3K8/MAP2K7/MAPK10/AKT3/CHUK/PAK1/FOS/PPP2R2D/MAPK9/AKT2/GRB2/PAK3/CD247/PPP2R5D/MAP2K1/IKBKB	3.68358573982463
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	21/764	122/9376	2.11243670071239	FOXO1/STAT1/NCOA2/MED13L/PRKCA/PIK3R1/NCOA1/MED24/TSC2/KAT2A/PLCB1/MTOR/PFKL/MED16/AKT3/MED27/AKT2/MED14/MDM2/MAP2K1/CREBBP	3.68358573982463
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	7/764	21/9376	4.09075043630017	XYLT1/CHSY3/CHST14/CHPF2/CSGALNACT2/CHST12/DSEL	4.22310614806211
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	14/764	68/9376	2.52663997536187	ZBTB16/TCF7L2/PIK3R1/RPS6KB1/MTOR/AKT3/CHUK/PER2/AKT2/GRB2/RARA/TCF7/MAP2K1/IKBKB	3.76307787776098
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	22/764	133/9376	2.02999645711136	FOXO1/INSR/FBXO25/BCL6/STK11/PIK3R1/SKP2/MAPK10/AKT3/CHUK/SGK3/PRKAG2/MAPK9/AKT2/GRB2/GADD45G/PRKAA1/SIRT1/MDM2/MAP2K1/CREBBP/IKBKB	3.56316047099023
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	17/764	93/9376	2.24331475539042	STAT1/MAF/PPP3CA/MAML2/TYK2/JAG1/PPP3R1/MAPK10/CHUK/FOS/JAK2/HLA-DMB/MAPK9/IL2RB/HLA-DRA/CD247/IKBKB	3.58887798792623
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	16/764	86/9376	2.28320954584196	PRKCA/PTK2/PIK3R1/RPS6KB1/ERBB4/MTOR/MAP2K7/MAPK10/AKT3/PAK1/ABL1/MAPK9/AKT2/GRB2/PAK3/MAP2K1	3.56056777738652
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	18/764	103/9376	2.14466527728359	CCL3/GNAQ/CCL3L1/PIK3R1/PPP2R1A/PLCB1/MAPK10/AKT3/CHUK/FOS/CCL5/PPP2R2D/MAPK9/AKT2/CD247/ADCY1/IKBKB/CASP8	3.47910309585968
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	12/764	56/9376	2.62976813762154	MAN1A1/MAGT1/TMEM258/MAN1A2/TUSC3/MGAT4B/DPAGT1/FUT8/MAN2A1/MOGS/ALG10B/DHRSX	3.64327695905387
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	46/764	362/9376	1.55945734864482	COL6A1/COL1A1/COL1A2/COL6A3/CREB3L2/PDGFRB/YWHAZ/PRLR/ITGB8/GNB2/PDGFRA/LAMA2/INSR/PRKCA/PTK2/STK11/PIK3R1/PPP2R1A/RPS6KB1/ERBB4/TSC2/PKN1/RPTOR/GNB1/MTOR/AKT3/CHUK/THBS3/PPP2R2D/SGK3/JAK2/MAGI2/AKT2/IL2RB/GRB2/ITGA9/PPP2R5D/PRKAA1/FLT3LG/ANGPT2/TNC/MDM2/MAP2K1/FGF2/IKBKB/GNB4	3.23327614546202
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	26/764	173/9376	1.84438458977696	OAS2/MX1/STAT1/OAS1/OAS3/ADAR/TYK2/PRKCA/PIK3R1/EIF2AK2/IRF9/AKT3/CHUK/CCL5/JAK2/HLA-DMB/AKT2/NXT1/HLA-DRA/TBK1/MAP2K1/NXT2/CREBBP/IFIH1/IKBKB/CASP8	3.3387119086339
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	29/764	203/9376	1.75317875841436	COL6A1/COL1A1/COL1A2/COL6A3/PDGFRB/ITGB8/PDGFRA/LAMA2/PRKCA/PTK2/PIK3R1/BIRC3/MAPK10/AKT3/THBS3/PAK1/PIP5K1A/PPP1R12C/MAPK9/AKT2/PIP5K1C/GRB2/PAK3/ITGA9/DIAPH1/RAPGEF1/TNC/MAP2K1/EMP1	3.23125098187531
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	34/764	250/9376	1.66902617801047	PDGFRA/CHMP1A/PARD3/HLA-C/CHMP1B/RAB31/ARFGAP1/DNM2/WASHC1/ITCH/WASHC2A/VPS45/EPS15/ZFYVE27/PSD3/WWP1/PIP5K1A/STAM2/VPS26B/TFRC/PIP5K1C/CHMP2B/CXCR4/IL2RB/VPS37A/EHD1/RUFY2/ZFYVE9/ARRB1/GRK3/AP2A2/HGS/MDM2/USP8	3.19339904027311
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	17/764	98/9376	2.12885992093172	INPP4B/DGKB/PRKCA/PIK3R1/IP6K1/PLCB1/MTM1/OCRL/MTMR14/PIP5K1A/PIP5K1C/PPIP5K2/DGKE/INPPL1/MTMR2/ITPR2/INPP5B	3.3458480574682
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	25/764	169/9376	1.81542179125747	CTSL/STK11/PIK3R1/RPS6KB1/TSC2/RPTOR/ATG4B/C9orf72/MTOR/ATG13/MAPK10/AKT3/MTMR14/VPS39/RAB1A/MAPK9/AKT2/PLEKHM1/ULK2/PRKAA1/CAMKK2/VPS33A/TBK1/SMCR8/MAP2K1	3.18600828602885
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	15/764	83/9376	2.21787674257238	XDH/GNPAT/CROT/PEX6/PEX3/ABCD3/PEX26/FAR2/HACL1/ABCD4/EPHX2/HSD17B4/PEX13/AGPS/NUDT19	3.31928636151671
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	18/764	109/9376	2.02661030789183	STAT1/RORA/PPP3CA/TYK2/PPP3R1/MTOR/MAPK10/CHUK/FOS/JAK2/HLA-DMB/MAPK9/IL1R1/IL2RB/HLA-DRA/CD247/RARA/IKBKB	3.21092081089095
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	18/764	109/9376	2.02661030789183	FOXO1/CREB3L2/INSR/PIK3R1/RPS6KB1/CPT1A/MTOR/MAPK10/AKT3/SLC27A4/PRKAG2/MAPK9/PTPA/AKT2/PYGB/PTPRF/PRKAA1/IKBKB	3.21092081089095
Human Diseases	Infectious disease: viral	hsa05162	Measles	21/764	136/9376	1.8949799815214	OAS2/MX1/STAT1/OAS1/OAS3/ADAR/TYK2/PIK3R1/EIF2AK2/MAPK10/IRF9/AKT3/CHUK/FOS/MAPK9/AKT2/IL2RB/TBK1/IFIH1/IKBKB/CASP8	3.13131743998224
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	24/764	163/9376	1.80695724793627	CREB3L2/YWHAZ/STAT1/MAP3K1/TYK2/PRKCA/PIK3R1/MAP2K7/MAPK10/AKT3/CHUK/FOS/JAK2/MAPK9/AKT2/NFATC4/HSPG2/GRB2/TBK1/MAP2K1/CREBBP/IFIH1/IKBKB/CASP8	3.09545218721971
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	28/764	201/9376	1.70956734651351	ZBTB16/PBX1/FOXO1/MITF/TCF3/MAF/JMJD1C/BCL6/MEIS1/DDX5/PTK2/SS18/BIRC3/PRCC/FUS/MLF1/ETV6/PER2/LDB1/DOT1L/IL2RB/FUT8/ELK4/GADD45G/RARA/ZBTB17/MDM2/CCNT1	3.02878831206242
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	23/764	156/9376	1.80937038528662	OAS2/MX1/YWHAZ/STAT1/PIAS1/IFIT1/OAS1/OAS3/TYK2/PIK3R1/PPP2R1A/CLDN7/EIF2AK2/IRF9/AKT3/CHUK/PPP2R2D/AKT2/GRB2/TBK1/MAP2K1/IKBKB/CASP8	3.03615860748379
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	13/764	70/9376	2.27913238593867	STK11/CPT1A/MTOR/MAPK10/AKT3/CHUK/JAK2/PRKAG2/MAPK9/AKT2/PRKAA1/CAMKK2/IKBKB	3.19936137700394
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	13/764	70/9376	2.27913238593867	PIK3R1/PRCC/AKT3/PAK1/ETS1/AKT2/EGLN1/EPAS1/GRB2/PAK3/RAPGEF1/MAP2K1/CREBBP	3.19936137700394
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	15/764	87/9376	2.1159053980863	TCF7L2/MSH3/PIK3R1/RPS6KB1/MTOR/MAPK10/AKT3/FOS/MAPK9/AKT2/APC/GRB2/GADD45G/TCF7/MAP2K1	3.11446052180771
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	28/764	205/9376	1.67620993487422	OAS2/ISG15/B2M/STAT1/OAS1/OAS3/TYK2/HLA-C/PIK3R1/SKP2/EIF2AK2/MAP2K7/MAPK10/IRF9/AKT3/CHUK/TAP2/HLA-DMB/MAPK9/AKT2/PSMD11/HLA-DRA/CD247/GADD45G/TBK1/MDM2/IKBKB/CASP8	2.91561675868562
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	17/764	105/9376	1.98693592620294	STAT1/PPP3CA/PIK3R1/PPP3R1/MAPK10/IRF9/AKT3/CHUK/PAK1/MAPK9/AKT2/NFATC4/BCL3/MDM2/ITPR2/IKBKB/CASP8	3.02900942204384
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	18/764	115/9376	1.92087411791486	AKAP13/CREB3L2/ADCY3/GNAQ/ARHGEF1/PRKCA/NR4A2/MMP16/PLCB1/STK39/ARHGEF11/WNK1/FOS/ADCY1/ARRB1/MAP2K1/ITPR2/LRP6	2.9593787557684
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	21/764	142/9376	1.8149104048374	MGST1/GSTT2B/CTSL/KEAP1/ACVR2A/PTK2/PIK3R1/MMP2/MAP2K7/MAPK10/AKT3/CHUK/DUSP1/FOS/MAPK9/AKT2/GSTA4/IL1R1/PRKAA1/ACVR2B/IKBKB	2.91433456317583
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	20/764	133/9376	1.8454513246467	CREB3L2/GNAQ/GNB2/PPP3CA/CACNA1D/PRKCA/PPP2R1A/PLCB1/GNB1/MAPK10/AKT3/FOS/PPP2R2D/MAPK9/AKT2/PPP2R5D/ARRB1/GRIA1/ITPR2/GNB4	2.92474670114494
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	16/764	98/9376	2.00363286675927	MARCKS/PLPP3/PTPRC/PRKCA/PIK3R1/RPS6KB1/DNM2/AKT3/PAK1/PIP5K1A/AKT2/PIP5K1C/WASF1/INPPL1/LIMK1/MAP2K1	2.97468535767145
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	24/764	170/9376	1.73255312596243	ARID1B/MGST1/GSTT2B/TCF7L2/KEAP1/PRKCA/CSNK1A1/PIK3R1/RPS6KB1/TXNRD2/MTOR/AKT3/FZD1/DVL3/AKT2/GSTA4/FZD3/APC/GRB2/GADD45G/TCF7/TXNRD1/MAP2K1/LRP6	2.87083616287287
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	17/764	107/9376	1.94979693692812	FOXO1/CREB3L2/GNAQ/PPP3CA/PPP3R1/CPT1A/PLCB1/PFKL/AKT3/PRKAG2/AKT2/PYGB/PRKAA1/SIRT1/ITPR2/PDE3B/CREBBP	2.94297463723139
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	16/764	99/9376	1.98339415093342	ADCY3/JAG1/PTK2/PIK3R1/RPS6KB1/MTOR/MMP2/MAPK10/AKT3/FOS/MAPK9/AKT2/GRB2/ADCY1/MDM2/MAP2K1	2.9296905267445
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	21/764	144/9376	1.78970331588133	ATXN1/PUM1/GNAQ/RORA/PRKCA/PIK3R1/PLCB1/MTOR/ATG13/MAPK10/AKT3/PPIF/MAPK9/AKT2/ATXN3/PSMD11/ULK2/GRIA1/ITPR2/PUM2/OPA1	2.84431450878245
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	11/764	59/9376	2.28804685420179	CTNNA2/TCF7L2/CTNNA3/PIK3R1/AKT3/AKT2/APC/GRB2/GADD45G/TCF7/MAP2K1	2.95596934764649
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	17/764	110/9376	1.89662065683008	INSR/PRKCA/PIK3R1/RPS6KB1/MTOR/PFKL/PFKFB3/AKT3/HK1/TFRC/AKT2/EGLN1/EPAS1/MKNK1/ANGPT2/MAP2K1/CREBBP	2.81733987272761
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	9/764	44/9376	2.51023322227511	MAN1A1/MAGT1/TMEM258/MAN1A2/TUSC3/MGAT4B/ST3GAL3/FUT8/MAN2A1	2.99063422976462
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	22/764	157/9376	1.71967852736186	FOXO1/ZFP36L1/PPP3CA/CACNA1D/HLA-C/PIK3R1/HIPK3/PPP3R1/TSC2/MTOR/AKT3/ETS1/AKT2/NFATC4/GADD45G/TRAF3IP2/TRPM7/CAPN1/SIRT1/MDM2/MAP2K1/ITPR2	2.70848709529042
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	21/764	148/9376	1.74133295599264	TCF7L2/JAG1/CSNK1A1/PIK3R1/NCOA1/RPS6KB1/MTOR/AKT3/FZD1/DVL3/FOS/AKT2/FZD3/APC/GRB2/GADD45G/TCF7/PGR/MAP2K1/FGF2/LRP6	2.7075137996754
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	7/764	30/9376	2.86352530541012	ATIC/ABCC4/CHUK/ABCC1/ABCC5/FPGS/IKBKB	3.04483203680186
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	21/764	149/9376	1.72964615763027	PDGFRB/PLPP3/ADCY3/PDGFRA/DGKB/INSR/PRKCA/PIK3R1/DNM2/TSC2/AGPAT3/PLCB1/MTOR/AKT3/PIP5K1A/AKT2/PIP5K1C/GRB2/DGKE/ADCY1/MAP2K1	2.67396353581151
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	5/764	17/9376	3.60948567908839	TXNRD2/SEPSECS/SCLY/CTH/TXNRD1	3.20733971335555
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	5/764	17/9376	3.60948567908839	PCDH9/MYH9/PCDH20/TFRC/PCDH7	3.20733971335555
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	13/764	78/9376	2.04537521815009	INPP4B/IP6K1/PLCB1/MTM1/OCRL/MTMR14/PIP5K1A/INPP5K/PIP5K1C/PPIP5K2/INPPL1/MTMR2/INPP5B	2.76124560582891
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	13/764	78/9376	2.04537521815009	PAN3/CNOT10/PARN/PFKL/CNOT7/CNOT6L/DCP1B/DIS3L/EXOSC10/EXOSC7/CNOT3/TENT4A/LSM1	2.76124560582891
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	20/764	142/9376	1.72848609984514	STAT1/MITF/PPP3CA/TYK2/PIK3R1/PPP3R1/MAP2K7/MAPK10/IRF9/AKT3/CHUK/FOS/MAPK9/AKT2/IL1R1/GRB2/MAP2K1/ITPR2/FOSL2/IKBKB	2.6052584516889
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	12/764	71/9376	2.07418331981417	STAT1/PRLR/PIK3R1/MAPK10/AKT3/FOS/JAK2/GALT/MAPK9/AKT2/GRB2/MAP2K1	2.70601186679754
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	17/764	115/9376	1.81415888914182	CREB3L2/ADCY3/GNAQ/GNB2/CACNA1D/PRKCA/PIK3R1/PLCB1/GNB1/AKT3/FOS/JAK2/AKT2/ADCY1/MAP2K1/ITPR2/GNB4	2.61643201114383
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	16/764	106/9376	1.85241529190951	FOXO1/CREB3L2/PDGFRB/PDGFRA/TCF7L2/PIK3R1/MTOR/AKT3/CHUK/AKT2/GRB2/TCF7/MDM2/MAP2K1/CREBBP/IKBKB	2.62872166593767
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	18/764	125/9376	1.76720418848168	GNAQ/CERS5/PRKCA/PIK3R1/PPP2R1A/SMPD1/PLCB1/MAPK10/AKT3/PPP2R2D/MAPK9/AKT2/NSMAF/ABCC1/PPP2R5D/S1PR2/CERS6/MAP2K1	2.57188732485039
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	20/764	144/9376	1.70447934845841	FOXO1/TRA2A/TCF7L2/CPT1A/MAP2K7/MAPK10/AKT3/CHUK/PRKAG2/IL17RC/MAPK9/AKT2/SCD5/PRKAA1/CAMKK2/SIRT1/TCF7/TBK1/IKBKB/CASP8	2.53735902035767
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	14/764	90/9376	1.90901687027341	STAT1/PPP3CA/PIK3R1/PPP3R1/RPS6KB1/MTOR/AKT3/CHUK/FOS/JAK2/AKT2/CD247/MAP2K1/IKBKB	2.58082861458927
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	26/764	204/9376	1.5641104609383	COL1A1/COL1A2/CTSL/ARHGEF1/DDX5/PRKCA/PTK2/HOXD10/PIK3R1/RPS6KB1/ERBB4/PLAUR/MTOR/MMP2/AKT3/PAK1/FZD1/PPP1R12C/AKT2/FZD3/HSPG2/GRB2/MDM2/MAP2K1/ITPR2/FGF2	2.42620515423867
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	44/764	388/9376	1.39169860204027	MT-ND3/MT-CO3/APOE/MT-CO2/DKK1/TUBB/MME/LRP1/GNAQ/SLC39A14/PPP3CA/INSR/CACNA1D/CSNK1A1/PIK3R1/PPP3R1/APP/PLCB1/MTOR/EIF2AK2/MAP2K7/ATG13/MT-CO1/MAPK10/AKT3/CHUK/FZD1/DVL3/PPIF/SLC39A10/MAPK9/AKT2/IDE/PSMD11/FZD3/BACE1/APC/ULK2/CAPN1/MAP2K1/ITPR2/LRP6/IKBKB/CASP8	2.34701929189991
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	16/764	110/9376	1.78505473584008	FBN1/ACVR2A/PPP2R1A/RPS6KB1/NEO1/LEMD3/TFRC/TGIF1/LTBP1/ZFYVE9/BMP8A/ACVR2B/THSD4/SKI/RGMB/CREBBP	2.46678011788773
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	19/764	138/9376	1.68965778890659	GNAQ/ARHGEF1/PTK2/PIK3R1/PKN1/MAP2K7/MAPK10/AKT3/CHUK/FOS/PIP5K1A/ELMO1/MAPK9/AKT2/PIP5K1C/LIMK1/TBK1/MAP2K1/IKBKB	2.43088557548571
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	15/764	101/9376	1.82261158052978	CREB3L2/ADCY3/MITF/GNAQ/TCF7L2/PRKCA/PLCB1/FZD1/DVL3/FZD3/ADCY1/TCF7/ASIP/MAP2K1/CREBBP	2.47559076413573
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	15/764	101/9376	1.82261158052978	COL3A1/COL1A1/COL1A2/FOXO1/STAT1/PRKCA/PIK3R1/PLCB1/MMP2/MAPK10/AKT3/JAK2/MAPK9/AKT2/DIAPH1	2.47559076413573
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	19/764	139/9376	1.67750197747561	CREB3L2/ADCY3/NCOA2/GREB1/GNAQ/FKBP5/PIK3R1/NCOA1/PLCB1/MMP2/AKT3/FOS/AKT2/GRB2/ADCY1/RARA/PGR/MAP2K1/ITPR2	2.39680555396575
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	7/764	34/9376	2.52663997536187	RORA/CRY1/PER2/BHLHE40/PRKAG2/CSNK1D/PRKAA1	2.65605133258583
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	14/764	93/9376	1.84743568090976	ADCY3/GNAQ/MAP3K1/CACNA1D/PRKCA/PLCB1/MMP2/MAP2K7/MAPK10/MAPK9/GRB2/ADCY1/MAP2K1/ITPR2	2.44615713616724
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	35/764	300/9376	1.43176265270506	PDGFRB/MAP3K20/STK3/PDGFRA/MAP3K1/PPP3CA/INSR/CACNA1D/MAP3K12/PRKCA/PPP3R1/ERBB4/MAP3K8/TAOK1/MAP2K7/MAPK10/AKT3/CHUK/DUSP1/PAK1/FOS/MAPK9/AKT2/IL1R1/GRB2/SRF/ELK4/MKNK1/GADD45G/FLT3LG/ARRB1/ANGPT2/MAP2K1/FGF2/IKBKB	2.26380369263692
Human Diseases	Cancer: specific types	hsa05214	Glioma	12/764	76/9376	1.93772389087903	PDGFRB/PDGFRA/PRKCA/PIK3R1/MTOR/AKT3/CAMK1/AKT2/GRB2/GADD45G/MDM2/MAP2K1	2.44467206361591
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	12/764	77/9376	1.91255864554294	STAT1/PIK3R1/RPS6KB1/MTOR/MAPK10/AKT3/CHUK/MAPK9/AKT2/GADD45G/MAP2K1/IKBKB	2.39479492752349
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	19/764	144/9376	1.61925538103549	TCF3/ACVR2A/MEIS1/PIK3R1/SETDB1/AKT3/FZD1/DVL3/JAK2/AKT2/FZD3/APC/GRB2/TCF7/SMARCAD1/REST/ACVR2B/MAP2K1/FGF2	2.2304035319329
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	20/764	155/9376	1.58351629792265	PBX1/CREB3L2/ADCY3/GNAQ/TCF7L2/CACNA1D/PLCB1/ASH2L/FZD1/DVL3/RASD1/FZD3/APC/STAR/ADCY1/TCF7/WDR5/MAP2K1/ITPR2/USP8	2.1817758769285
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	10/764	62/9376	1.97939537240331	ATXN1/TLE1/MAML2/JAG1/KAT2A/ITCH/CTBP1/DVL3/DTX1/CREBBP	2.30444359500639
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	13/764	89/9376	1.79257603388435	PDGFRB/GJA1/TUBB/ADCY3/GNAQ/PDGFRA/PRKCA/PLCB1/GRB2/CSNK1D/ADCY1/MAP2K1/ITPR2	2.237579751624
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	12/764	80/9376	1.84083769633508	PDGFRB/PDGFRA/PRKCA/PIK3R1/RPS6KB1/MTOR/AKT3/JAK2/AKT2/GRB2/MAP2K1/FGF2	2.24951770974992
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	21/764	166/9376	1.55251371980067	CREB3L2/EDNRA/ADCY3/GNAQ/ATP2B4/PPP3CA/PDE5A/INSR/CACNA1D/PPP3R1/SLC8A1/PLCB1/AKT3/PPIF/AKT2/NFATC4/SRF/ADCY1/MAP2K1/ITPR2/PDE3B	2.13918134469221
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	7/764	38/9376	2.2606778726922	ENPP1/ENPP3/NT5E/NAPRT/SIRT3/SIRT1/NNMT	2.31925926728578
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	11/764	73/9376	1.84924334791652	BST2/MX1/APOBEC3C/KAT2A/SERINC3/ELL/CXCR4/HGS/TNPO3/CREBBP/CCNT1	2.16951361654072
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	8/764	47/9376	2.08889383981286	INSR/CACNA1D/PIK3R1/MTOR/MAPK10/HK1/MAPK9/IKBKB	2.22893410912182
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	18/764	140/9376	1.57786088257292	ADCY3/GNAQ/GNB2/JAG1/RPS6KB1/SLC8A1/PLCB1/GNB1/MTOR/AKT3/PRKAG2/AKT2/ADCY1/PRKAA1/MAP2K1/ITPR2/PDE3B/GNB4	2.05175574989474
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	19/764	150/9376	1.55448516579407	CTNNA2/TCF7L2/CTNNA3/CSNK1A1/PIK3R1/RPS6KB1/MTOR/AKT3/FZD1/DVL3/AKT2/FZD3/APC/GRB2/GADD45G/TCF7/MAP2K1/FGF2/LRP6	2.03896205294732
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	12/764	83/9376	1.77430139405791	PCBP1/CCL4/ADAR/CCL4L2/POLR1C/CHUK/CCL5/POLR3E/DDX41/TBK1/IKBKB/CASP8	2.11033511615568
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	10/764	65/9376	1.88803866290777	GNAQ/CACNA1D/PRKCA/PIK3R1/PLCB1/AKT3/AKT2/ARRB1/MAP2K1/ITPR2	2.13978774628723
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	15/764	112/9376	1.64360508601346	STAT1/LAMA2/TYK2/BIRC3/MAPK10/AKT3/CHUK/PPIF/JAK2/HLA-DMB/MAPK9/AKT2/HLA-DRA/IKBKB/CASP8	2.04084260664632
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	11/764	75/9376	1.79993019197208	MGST1/GSTT2B/REV3L/MSH3/PIK3R1/BIRC3/AKT3/AKT2/GSTA4/MDM2/CASP8	2.07156328470242
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	18/764	142/9376	1.55563748986063	PIAS1/MAP3K1/KEAP1/UBA1/BIRC3/FBXO4/ANAPC1/SKP2/FBXW8/ITCH/CUL7/UBE2D3/WWP1/TRIM37/PPIL2/UBE4A/MDM2/RHOBTB1	1.98710622871504
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	10/764	67/9376	1.8316792998359	GNAQ/PPP3CA/PRKCA/PPP3R1/PLCB1/ADCY1/GRIA1/MAP2K1/ITPR2/CREBBP	2.0348016696246
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	21/764	174/9376	1.48113377866041	MAN1A1/CANX/SEC23B/MAP2K7/MAGT1/MAPK10/EDEM3/ERO1A/UBE2D3/TMEM258/MAN1A2/TUSC3/MAPK9/ATXN3/MBTPS2/MOGS/PDIA4/CAPN1/SEC31A/SIL1/SEC24C	1.90800568689929
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	25/764	216/9376	1.42039945704867	CCL3/ABCA1/ARHGEF1/PPP3CA/CCL3L1/MIB1/PRKCA/PTK2/PIK3R1/PPP3R1/PLCB1/MAP2K7/MAPK10/AKT3/ERO1A/CHUK/FOS/CCL5/JAK2/MAPK9/AKT2/CASP6/TBK1/IKBKB/CASP8	1.86175098424864
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	11/764	77/9376	1.75317875841436	PIK3R1/CTBP1/AKT3/CHUK/ABL1/AKT2/GRB2/GADD45G/MDM2/MAP2K1/IKBKB	1.97654000537797
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	25/764	217/9376	1.41385383743094	CREB3L2/MGST1/ADCY3/GSTT2B/CACNA1D/BCL6/JAG1/PRKCA/PIK3R1/RPS6KB1/MTOR/KPNB1/AKT3/FOS/JAK2/AKT2/GSTA4/UGT2B7/GRB2/EPHX2/ADCY1/ARRB1/PGR/MAP2K1/FGF2	1.83710141147966
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	15/764	116/9376	1.58692904856472	ADCY3/GNAQ/GNB2/PPP3CA/CACNA1D/PRKCA/PPP3R1/PLCB1/GNB1/NCDN/ADCY1/GRK3/GRIA1/ITPR2/GNB4	1.89447732919937
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	13/764	97/9376	1.64473471150213	ADCY3/GNAQ/GNB2/CACNA1D/PRKCA/PLCB1/GNB1/FOS/PER2/RASD1/ADCY1/GRIA1/GNB4	1.90106356867625
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	8/764	51/9376	1.92505902884714	ADCY3/PRKCA/ATP6V1C1/TCIRG1/ATP6V1E1/ERO1A/PDIA4/KDELR2	1.97292429604198
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	19/764	157/9376	1.48517690999433	PBX1/ABCA1/LRP1/PTK2/CPT1A/LIPA/JAK2/VPS39/TYRO3/ELMO1/TGFBRAP1/MEGF10/NFATC4/ANO6/VPS33A/SIRT1/ATP11A/VPS8/MAP2K1	1.8259477665252
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	19/764	157/9376	1.48517690999433	SNAI2/YWHAZ/CTNNA2/STK3/TCF7L2/CTNNA3/PARD3/PPP2R1A/BIRC3/TEAD1/FZD1/DVL3/PPP2R2D/FZD3/APC/GLI2/CSNK1D/BMP8A/TCF7	1.8259477665252
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	17/764	137/9376	1.52283410402415	CTSL/PIK3R1/BIRC3/MAPK10/AKT3/CHUK/FOS/MAPK9/AKT2/GADD45G/CASP6/LMNB2/CAPN1/MAP2K1/ITPR2/IKBKB/CASP8	1.83608175648808
Organismal Systems	Digestive system	hsa04978	Mineral absorption	9/764	61/9376	1.81066002918204	MT1G/ATP2B4/MT1E/MT2A/TRPM6/CYBRD1/SLC8A1/TRPM7/MT1A	1.89187550749757
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	10/764	71/9376	1.72848609984514	ATP6V1C1/TCIRG1/MAPK10/ATP6V1E1/CHUK/PAK1/CCL5/MAPK9/CSK/IKBKB	1.83515420004756
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	10/764	71/9376	1.72848609984514	PDGFRB/PDGFRA/PIK3R1/SIRT3/MTOR/PFKL/AKT3/HK1/AKT2/MAP2K1	1.83515420004756
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	10/764	72/9376	1.70447934845841	ISG15/MAP3K1/ADAR/MAPK10/CHUK/MAPK9/TBK1/IFIH1/IKBKB/CASP8	1.78722804497434
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	9/764	63/9376	1.75317875841436	TCF7L2/FZD1/DVL3/FZD3/APC/GLI2/GADD45G/HHIP/TCF7	1.7865033851182
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	7/764	45/9376	1.90901687027341	ABCA1/ABCD3/ABCC4/TAP2/ABCD4/ABCC1/ABCC5	1.82051563192696
Human Diseases	Cancer: specific types	hsa05218	Melanoma	10/764	73/9376	1.68113031628774	PDGFRB/MITF/PDGFRA/PIK3R1/AKT3/AKT2/GADD45G/MDM2/MAP2K1/FGF2	1.74004482867048
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	27/764	248/9376	1.33609187637223	AHNAK/TUBB/PTPRC/TCF7L2/FBXO22/BIRC3/EXOC4/DNM2/PKN1/MAP2K7/MAPK10/AKT3/CHUK/PAK1/FOS/VPS39/ELMO1/MAPK9/AKT2/PLEKHM1/PAK3/DYNC1LI2/VPS33A/TCF7/MAP2K1/IKBKB/CASP8	1.59763051467391
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	12/764	93/9376	1.58351629792265	SNAI2/CTNNA2/TCF7L2/CTNNA3/INSR/PARD3/CTNND1/WASF1/PTPRJ/PTPRF/TCF7/CREBBP	1.68434323499458
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	13/764	103/9376	1.54892492248259	COL3A1/COL6A1/COL1A1/ELN/COL1A2/COL5A2/COL6A3/COL15A1/MME/SLC7A8/COL5A3/SLC8A1/COL18A1	1.66840598304493
NA	NA	hsa04518	Integrin signaling	18/764	154/9376	1.4344189841572	COL6A1/COL1A1/COL1A2/COL6A3/PDGFRB/ITGB8/FBN1/PDGFRA/LAMA2/PTK2/PIK3R1/MTOR/AKT3/THBS3/AKT2/ITGA9/TNC/FERMT1	1.6189629278994
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	9/764	65/9376	1.699234796617	PBX1/CREB3L2/ADCY3/GNAQ/CACNA1D/PLCB1/STAR/ADCY1/ITPR2	1.68485237419677
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	10/764	75/9376	1.63630017452007	CREB3L2/ADCY3/GNAQ/PRKCA/CANX/PLCB1/GSR/PDIA4/ADCY1/ITPR2	1.64781388777926
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	21/764	187/9376	1.37816725928829	OAS2/STAT1/OAS1/OAS3/TYK2/BIRC3/PKN1/PLCB1/MAPK10/IRF9/CHUK/CCL5/DNM1L/DHX33/GBP1/MAPK9/TRPM7/TBK1/ITPR2/IKBKB/CASP8	1.5557897664578
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	4/764	21/9376	2.33757167788581	BCAT1/ENPP1/ENPP3/PPCDC	1.82761672052539
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	11/764	86/9376	1.56970656276635	GJA1/CTNNA2/ITGB8/TCF7L2/LAMA2/CTNNA3/CACNA1D/SLC8A1/ITGA9/TCF7/CDH2	1.58078533356025
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	18/764	158/9376	1.398104579495	YWHAZ/MCM3/ORC4/PPP2R1A/ANAPC1/SKP2/ORC2/ABL1/GADD45G/MCM7/CDK7/PPP2R5D/NIPBL/NDC80/ORC5/ZBTB17/MDM2/CREBBP	1.50309929777163
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	5/764	30/9376	2.04537521815009	PIGL/MPPE1/PIGS/PIGG/PIGB	1.70804868893455
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	15/764	128/9376	1.43815445026178	ENPP1/ENPP3/ADCY3/NT5E/XDH/PDE5A/PDE9A/ATIC/ADK/ENTPD6/RRM2B/AK3/ADCY1/ENTPD4/PDE3B	1.48658110448248
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/764	14/9376	2.62976813762154	ST3GAL3/FUT8/B4GALT4	1.81754775008757
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	7/764	49/9376	1.75317875841436	GXYLT2/PLOD3/COLGALT1/GALNT11/ST3GAL3/POFUT1/POMT2	1.57436498377027
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	12/764	98/9376	1.50272465006945	CREB3L2/ADCY3/GNAQ/ATP2B4/CACNA1D/PRKCA/NR4A2/PLCB1/CAMK1/STAR/ADCY1/ITPR2	1.49003455848442
NA	NA	hsa04981	Folate transport and metabolism	5/764	31/9376	1.97939537240331	ABCC4/MTHFD1/ABCC1/ABCC5/FPGS	1.62678271266075
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	8/764	59/9376	1.66403407578312	ADCY3/INSR/PIK3R1/PNPLA2/AKT3/AKT2/ADCY1/PDE3B	1.52390758721589
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	9/764	69/9376	1.60072843159572	PRKCA/PIK3R1/MAP2K7/MAPK10/AKT3/MAPK9/AKT2/GRB2/MAP2K1	1.49168863972745
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	24/764	227/9376	1.29750674631547	MT-ND3/MT-CO3/MT-CO2/MGST1/GSTT2B/KEAP1/PTK2/PIK3R1/MAP2K7/MT-CO1/MAPK10/AKT3/CHUK/FOS/PPIF/ABL1/MAPK9/AKT2/GSTA4/GRB2/EPHX2/PTPRJ/MAP2K1/IKBKB	1.35146013656026
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	8/764	60/9376	1.63630017452007	PPP3CA/PRKCA/PTK2/PIK3R1/PPP3R1/AKT3/AKT2/MAP2K1	1.47266252195434
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	4/764	23/9376	2.13430457546096	POMGNT2/CHST10/ST3GAL3/POMT2	1.62217775518227
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	25/764	238/9376	1.28910202824585	PDGFRB/GNB2/PDGFRA/INSR/PRKCA/PIK3R1/GNB1/MAPK10/AKT3/CHUK/PAK1/ETS1/RGL2/ABL1/MAPK9/AKT2/GRB2/PAK3/FLT3LG/TBK1/ANGPT2/MAP2K1/FGF2/IKBKB/GNB4	1.34553298007505
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	20/764	184/9376	1.3339403596631	PPP3CA/PARD3/PRKCA/PTK2/PIK3R1/PPP3R1/NEO1/LRIG2/PAK1/ABL1/FZD3/CXCR4/NFATC4/SEMA4C/PAK3/PLXNC1/LIMK1/SEMA5A/SLIT3/SRGAP3	1.36255211173367
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	5/764	32/9376	1.91753926701571	GLB1/PFKL/HK1/GALM/GALT	1.54850831091974
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	5/764	32/9376	1.91753926701571	RPTOR/ATG4B/MTOR/ATG13/ULK2	1.54850831091974
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	3/764	15/9376	2.4544502617801	ST6GALNAC5/GLB1/SLC33A1	1.67905022770699
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	11/764	91/9376	1.48345894942754	PPP3CA/PIK3R1/PPP3R1/AKT3/CHUK/FOS/AKT2/GRB2/INPPL1/MAP2K1/IKBKB	1.38028781151178
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	17/764	154/9376	1.35472904059291	ADCY3/GNAQ/PPP3CA/CACNA1D/PRKCA/PPP3R1/PLCB1/FOS/PPP1R12C/PRKAG2/CAMK1/NFATC4/ADCY1/PRKAA1/CAMKK2/MAP2K1/ITPR2	1.32197990215232
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	7/764	52/9376	1.6520338300443	APOE/LIPG/ABCA1/LRP1/LIPA/STAR/STARD3NL	1.40427115618599
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	26/764	253/9376	1.26117997640875	FOXO1/PTK2/PIK3R1/RPS6KB1/SEPTIN2/RPTOR/PLCB1/MTOR/MAPK10/AKT3/CHUK/UBE2D3/CCL5/HK1/GLMN/ELMO1/MAPK9/AKT2/IL1R1/WASF1/DIAPH1/CAPN1/TBK1/MDM2/ITPR2/IKBKB	1.25432941918318
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	12/764	103/9376	1.42977685152239	CSTF2/PPP2R1A/DDX19A/FUS/SYMPK/NCBP1/PPP2R2D/SMG5/FIP1L1/NXT1/PPP2R5D/NXT2	1.30626656048198
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	24/764	232/9376	1.26954323885178	PDGFRB/ITGB8/PDGFRA/ARHGEF1/PTK2/PIK3R1/SPATA13/MYH9/C7/AKT3/PAK1/PIP5K1A/PPP1R12C/AKT2/PIP5K1C/CXCR4/APC/WASF1/PAK3/ITGA9/DIAPH1/LIMK1/MAP2K1/FGF2	1.23818241924416
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	11/764	93/9376	1.45155660642909	LAMA2/PTK2/PIK3R1/BIRC3/SKP2/AKT3/CHUK/AKT2/GADD45G/ZBTB17/IKBKB	1.30343628440825
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	7/764	53/9376	1.62086338042082	GNAQ/ATP2B4/PRKCA/DNM2/SLC8A1/PLCB1/AP2A2	1.35000831921624
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	12/764	104/9376	1.41602899718083	PLPP3/GNPAT/DGKB/PISD/CEPT1/LYPLA2/CRLS1/AGPAT3/SELENOI/DGKE/PCYT1A/LPCAT2	1.27067319067866
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	5/764	34/9376	1.80474283954419	POLR2M/POLR1C/POLR1B/POLR3E/POLR1A	1.40009322817163
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	18/764	168/9376	1.31488406881077	STAT1/CHMP1A/TYK2/CHMP1B/BIRC3/SMPD1/EIF2AK2/MAPK10/IRF9/DNM1L/JAK2/MAPK9/CHMP2B/PYGB/TRPM7/CAPN1/PGAM5/CASP8	1.22660005842529
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	36/764	368/9376	1.20054632369679	MT-ND3/MT-CO3/MT-CO2/TUBB/PPP3CA/SRSF7/NUP85/NUP37/PPP3R1/ERBB4/NUP35/FUS/C9orf72/MTOR/NCBP1/ATG13/MT-CO1/NUP155/RAB1A/DNAH14/NXT1/PSMD11/CHMP2B/CCS/NDC1/NUP133/SEH1L/ULK2/NUP62/NUP43/GRIA1/POM121C/TBK1/SMCR8/NXT2/NUP88	1.16897367923919
Organismal Systems	Immune system	hsa04611	Platelet activation	14/764	126/9376	1.36358347876672	COL3A1/COL1A1/COL1A2/ADCY3/GNAQ/ARHGEF1/APBB1IP/PIK3R1/STIM1/PLCB1/AKT3/AKT2/ADCY1/ITPR2	1.22376732655511
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	11/764	95/9376	1.42099751997796	CCL3/IL15/CTSL/CCL3L1/ATP6V1C1/TCIRG1/ATP6V1E1/FOS/CCL5/HLA-DMB/HLA-DRA	1.22835602599897
NA	NA	hsa04519	Cadherin signaling	39/764	404/9376	1.18469752734436	LHFPL3/PDGFRB/CDH11/GJA1/YWHAZ/CTNNA2/PCDH9/STK3/PDGFRA/TCF7L2/GABRA2/KRT8/CTNNA3/RERE/PTK2/CSNK1A1/TAOK1/CTNND1/MPDZ/MAPK10/CHUK/TEAD1/PCDH20/FZD1/DVL3/MAPK9/FZD3/APC/WASF1/PRICKLE2/MYO1B/TCF7/PCDH7/TMC1/MAP2K1/LRP6/CDH2/CREBBP/IKBKB	1.13028363159358
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	10/764	85/9376	1.44379427163536	ENPP1/ENPP3/NT5E/XDH/NT5C3A/ADK/ENTPD6/RRM2B/AK3/ENTPD4	1.22416577080204
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	16/764	149/9376	1.31782564390878	MT-ND3/ADCY3/GNAQ/GNB2/GABRA2/CACNA1D/PRKCA/PLCB1/GNB1/NAPEPLD/MAPK10/MAPK9/ADCY1/GRIA1/ITPR2/GNB4	1.16474838340549
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	7/764	55/9376	1.56192289386007	PSAP/PLPP3/CERS5/GLB1/SMPD1/UGCG/CERS6	1.24482162468625
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	21/764	205/9376	1.25715745115566	MT-ND3/MT-CO3/COL3A1/COL1A1/COL1A2/MT-CO2/INSR/PRKCA/PIK3R1/CPT2/PLCB1/MTOR/GSR/MMP2/MT-CO1/MAPK10/AKT3/PPIF/MAPK9/PTPA/AKT2	1.10878668818996
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	5/764	36/9376	1.70447934845841	ENPP1/ENPP3/AGL/HK1/PYGB	1.26132320489984
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	7/764	56/9376	1.53403141361257	CSNK1A1/GLI2/CSNK1D/SPOPL/ARRB1/HHIP/GRK3	1.19380438217736
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	3/764	18/9376	2.04537521815009	MTRR/ZNF76/ABCD4	1.32220026375091
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	13/764	120/9376	1.32949389179756	MAP3K1/PIK3R1/MAP2K7/MAPK10/AKT3/ABL1/MAPK9/AKT2/GRB2/RAPGEF1/KIDINS220/MAP2K1/IKBKB	1.08194858922004
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	5/764	37/9376	1.65841233904061	GALK2/GMDS/HK1/GALT/NANP	1.19516796104375
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	5/764	37/9376	1.65841233904061	TCF7L2/GADD45G/TCF7/MAP2K1/NCOA4	1.19516796104375
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	9/764	78/9376	1.41602899718083	CTNNA2/CTNNA3/PTK2/PIK3R1/SEPTIN2/DNM2/CD2AP/ELMO1/WASF1	1.0988956122337
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	12/764	110/9376	1.33879105188006	ADCY3/PIK3R1/ANAPC1/MAPK10/AKT3/MAPK9/AKT2/ADCY1/PGR/MAP2K1/PDE3B/SPDYE3	1.06454109852825
NA	NA	hsa04517	IgSF CAM signaling	29/764	299/9376	1.19028524400707	FOXO1/TUBB/PARD3/PRKCA/PTK2/PIK3R1/MYH9/APP/MPDZ/MAPK10/AKT3/PAK1/TRIO/CD2AP/MAGI2/NCAM1/ABL1/MAPK9/AKT2/CSK/GRB2/PAK3/EPB41L1/PTPRF/SLIT3/MAP2K1/SRGAP3/CDH2/RAPGEF6	0.995978227892648
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	25/764	254/9376	1.20789875087604	PDGFRB/EDNRA/ADCY3/GNAQ/ATP2B4/PDGFRA/PPP3CA/STIM2/CACNA1D/PRKCA/PPP3R1/ERBB4/STIM1/SLC8A1/PLCB1/ASPH/PPIF/CAMK1/CXCR4/NFATC4/TPCN2/ADCY1/P2RX4/ITPR2/FGF2	1.0004698635567
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	10/764	89/9376	1.3789046414495	COL6A1/COL1A1/COL1A2/COL6A3/ITGB8/LAMA2/THBS3/HSPG2/ITGA9/TNC	1.0697135886744
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	6/764	48/9376	1.53403141361257	BCAT1/HMGCS1/AUH/HIBCH/OXCT1/ACADSB	1.1047740419727
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	6/764	48/9376	1.53403141361257	CACNA1D/PIK3R1/PLCB1/AKT3/HK1/AKT2	1.1047740419727
Organismal Systems	Endocrine system	hsa04924	Renin secretion	8/764	69/9376	1.42286971697397	EDNRA/GNAQ/PPP3CA/CACNA1D/PPP3R1/PLCB1/ITPR2/PDE3B	1.05004178213984
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	8/764	69/9376	1.42286971697397	CREB3L2/PPP3CA/CACNA1D/PRKCA/PPP3R1/FOS/GRIA1/SIRT1	1.05004178213984
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	14/764	134/9376	1.28217550988513	CALCRL/EDNRA/ADCY3/GNAQ/ARHGEF1/CACNA1D/PRKCA/MYH9/PLCB1/ARHGEF11/PPP1R12C/ADCY1/MAP2K1/ITPR2	0.979871311104751
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	7/764	59/9376	1.45602981631023	ENPP1/ENPP3/NT5E/NT5C3A/ENTPD6/RRM2B/ENTPD4	1.04655366707236
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	7/764	59/9376	1.45602981631023	MGST1/GSTT2B/LAP3/GSR/GSTA4/RRM2B/PGD	1.04655366707236
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	21/764	212/9376	1.21564753531562	PDGFRB/ADCY3/GNAQ/PDGFRA/INSR/PARD3/APBB1IP/PRKCA/PIK3R1/PLCB1/CTNND1/AKT3/MAGI2/AKT2/ADCY1/SIPA1/RAPGEF1/ANGPT2/MAP2K1/FGF2/RAPGEF6	0.945910825910112
Human Diseases	Substance dependence	hsa05032	Morphine addiction	10/764	91/9376	1.34859904493412	ADCY3/GNB2/GABRA2/PRKCA/GNB1/ADCY1/ARRB1/GRK3/PDE3B/GNB4	0.995259294293687
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	17/764	168/9376	1.24183495387684	PDGFRB/IL15/STAT1/PRLR/PIAS1/PDGFRA/TYK2/PIK3R1/MTOR/IRF9/AKT3/STAM2/JAK2/AKT2/IL2RB/GRB2/CREBBP	0.942044383747057
Organismal Systems	Nervous system	hsa04730	Long-term depression	7/764	60/9376	1.43176265270506	GNAQ/PRKCA/PPP2R1A/PLCB1/GRIA1/MAP2K1/ITPR2	0.99927786048136
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	11/764	103/9376	1.31062878056219	COL3A1/COL1A1/COL1A2/GNAQ/LAMA2/PRKCA/PTK2/PIK3R1/PLCB1/IL1R1/ADCY1	0.944127137919025
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	44/764	480/9376	1.12495636998255	MT-ND3/MT-CO3/MT-CO2/DKK1/ATXN1/TUBB/GNAQ/PPP3CA/CACNA1D/UBA1/PRKCA/CSNK1A1/PPP3R1/APP/PLCB1/FUS/C9orf72/MTOR/MAP2K7/ATG13/MT-CO1/MAPK10/SNCAIP/FZD1/DVL3/PPIF/RAB1A/DNAH14/MAPK9/ATXN3/PSMD11/FZD3/CHMP2B/CCS/APC/ULK2/CAPN1/GRIA1/TBK1/SMCR8/MAP2K1/ITPR2/LRP6/CASP8	0.837070311129429
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	10/764	94/9376	1.30555864988303	MAPK10/CHUK/FOS/IL17RC/MAPK9/TRAF3IP2/S100A9/TBK1/IKBKB/CASP8	0.8867843786375
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	5/764	42/9376	1.46098229867863	PCBP1/SLC39A14/SAT1/TFRC/NCOA4	0.891775020187389
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	4/764	32/9376	1.53403141361257	BIRC3/MAPK10/MAPK9/CASP8	0.901271598937595
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	19/764	200/9376	1.16586387434555	TUBB/ARHGEF1/MYH9/CLDN7/ARHGEF11/MAPK10/CHUK/PAK1/FOS/RAB1A/ABL1/MAPK9/IL1R1/WASF1/PAK3/MYO1B/SEC24C/IKBKB/CASP8	0.706188121121925
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	7/764	65/9376	1.32162706403544	LIPG/PLPP3/DGKB/PNPLA2/AGPAT3/ABHD16A/DGKE	0.774981630015864
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	15/764	155/9376	1.18763722344199	TUBB/CTSL/STX18/CANX/HLA-C/ATP6V1C1/TCIRG1/ATP6V1E1/THBS3/TAP2/HLA-DMB/TFRC/HLA-DRA/DYNC1LI2/HGS	0.701578292117963
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	10/764	99/9376	1.23962134433339	ADCY3/GNAQ/PRKCA/PIK3R1/PLCB1/MAPK10/MAPK9/IL1R1/ADCY1/ITPR2	0.713870813481007
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	5/764	44/9376	1.39457401237506	TAF6/TAF3/TAF1/CDK7/GTF2E1	0.781353853285494
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	3/764	23/9376	1.60072843159572	ICMT/HMGCS1/PDSS2	0.859106380880193
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	10/764	100/9376	1.22722513089005	CCL4/CCL3/XCL2/XCL1/CCL3L1/CCL4L2/CCL5/ACKR3/CXCR4/IL2RB	0.680387457681152
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	15/764	157/9376	1.17250808683763	MT-CO3/MT-CO2/INSR/PIK3R1/ITCH/MT-CO1/MAPK10/AKT3/FOS/PRKAG2/MAPK9/AKT2/PRKAA1/IKBKB/CASP8	0.649228661504904
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	9/764	89/9376	1.24101417730455	PLCL1/ADCY3/GNB2/GABRA2/CACNA1D/PRKCA/GNB1/ADCY1/GNB4	0.680424867691201
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	16/764	170/9376	1.15503541730828	MAP3K1/CACNA1D/PARD3/STK11/PPP2R1A/MYH9/CLDN7/SYMPK/MAP2K7/MPDZ/MAPK10/PPP2R2D/PRKAG2/MAPK9/PRKAA1/RAPGEF6	0.607575432771464
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	4/764	35/9376	1.40254300673149	PFKL/PFKFB3/GMDS/HK1	0.710607732901272
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	10/764	102/9376	1.20316189302946	ADCY3/SCTR/GNAQ/ATP2B4/PRKCA/PLCB1/TPCN2/ADCY1/SLC4A2/ITPR2	0.614453606838238
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	6/764	57/9376	1.29181592725269	ELOVL5/CPT1A/CPT2/SCD5/HSD17B4/ACADSB	0.658176043697652
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	11/764	115/9376	1.17386751650353	GNAQ/GNB2/CACNA1D/PRKCA/APP/PLCB1/GNB1/DUSP1/MAP2K1/ITPR2/GNB4	0.558751543396426
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	7/764	70/9376	1.22722513089005	LAMA2/EIF4G3/HLA-C/HLA-DMB/ABL1/HLA-DRA/CASP8	0.56833468970518
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	8/764	82/9376	1.19729281062444	B2M/CTSL/CANX/HLA-C/CD74/TAP2/HLA-DMB/HLA-DRA	0.534437789246725
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	21/764	235/9376	1.09666926590175	MT-ND3/MT-CO3/ZNF516/MT-CO2/ARID1B/CREB3L2/ADCY3/RPS6KB1/PNPLA2/CPT1A/TSC2/CPT2/RPTOR/MTOR/MT-CO1/PRKAG2/GRB2/ADCY1/PRKAA1/BMP8A/COX15	0.446998230769339
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	14/764	154/9376	1.11565920990005	CREB3L2/ADCY3/GNAQ/ATP2B4/CACNA1D/PRKCA/PPP2R1A/SLC8A1/PLCB1/AKT3/PPP2R2D/AKT2/PPP2R5D/ADCY1	0.431030824911079
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/764	27/9376	1.36358347876672	ELOVL5/SCD5/HSD17B4	0.563486803701746
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	21/764	238/9376	1.08284570372652	OAS2/ISG15/C1S/MX1/STAT1/OAS1/OAS3/ADAR/TYK2/PRKCA/PIK3R1/C7/EIF2AK2/MAPK10/IRF9/CHUK/FOS/MAPK9/TBK1/IFIH1/IKBKB	0.385578846671939
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	7/764	73/9376	1.17679122140142	PRKCA/PIK3R1/AKT3/AKT2/GRB2/GADD45G/MAP2K1	0.451638465059781
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	4/764	39/9376	1.25869244193852	MTHFD2/ATIC/MTHFD1/CTH	0.482161657489921
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	3/764	28/9376	1.31488406881077	ST3GAL3/B4GALT4/ST3GAL6	0.496993443363102
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	3/764	28/9376	1.31488406881077	ATP6V1C1/TCIRG1/ATP6V1E1	0.496993443363102
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	5/764	51/9376	1.20316189302946	PLPP3/CEPT1/SELENOI/AGPS/LPCAT2	0.433294549091896
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	2/764	17/9376	1.44379427163536	CYP46A1/HSD17B4	0.545471087801882
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	3/764	29/9376	1.26954323885178	STK3/TEAD1/PAK1	0.432983779538457
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	7/764	76/9376	1.1303389363461	ADCY3/GNAQ/PRKCA/PLCB1/ADCY1/SLC4A2/ITPR2	0.339797204258104
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	20/764	233/9376	1.05341212951936	NID1/COL3A1/COL6A1/COL1A1/VCAN/ELN/COL1A2/COL5A2/COL6A3/ITGB8/FBN1/LAMA2/COL5A3/MYH9/THBS3/SDC3/HSPG2/ITGA9/DIAPH1/LMNB2	0.24589732313953
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	12/764	138/9376	1.06715228773048	YWHAZ/ADCY3/PPP3CA/PPP2R1A/PPP3R1/ANAPC1/PPP2R5D/ADCY1/PGR/MAP2K1/ITPR2/SPDYE3	0.236696417021109
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/764	19/9376	1.29181592725269	GLB1/SGSH	0.379225719996677
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	3/764	31/9376	1.18763722344199	SRP68/GET1/SRP54	0.311666769057784
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	4/764	43/9376	1.14160477292098	CPT1A/GCDH/CPT2/ACADSB	0.277192703157865
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	10/764	116/9376	1.05795269904315	CTNNA2/CTNNA3/PRKCA/PTK2/PIK3R1/CLDN7/CTNND1/MMP2/CXCR4/SIPA1	0.187058512049523
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	19/764	226/9376	1.03173794189872	CREB3L2/EDNRA/ADCY3/ATP2B4/CACNA1D/PIK3R1/ABCC4/MAPK10/AKT3/PAK1/FOS/MAPK9/AKT2/ADCY1/HHIP/GRIA1/MAP2K1/PDE3B/CREBBP	0.143847639692549
Organismal Systems	Digestive system	hsa04970	Salivary secretion	8/764	93/9376	1.05567753194843	ADCY3/GNAQ/ATP2B4/PRKCA/PLCB1/ADCY1/SLC4A2/ITPR2	0.160715432649266
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/764	20/9376	1.22722513089005	LIPA/FDFT1	0.30297483696093
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/764	20/9376	1.22722513089005	GMDS/NANP	0.30297483696093
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	7/764	82/9376	1.04763120929639	MGST1/GSTT2B/XDH/TPMT/GSTA4/UGT2B7/RRM2B	0.129026081157947
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	17/764	205/9376	1.01769888903078	CREB3L2/YWHAZ/HLA-C/PIK3R1/SKP2/KAT2A/EIF2AK2/IRF9/HDAC7/GRB2/POLB/SRF/GTF2E1/MDM2/CHD4/CREBBP/CASP8	0.0763123621924362
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	3/764	33/9376	1.11565920990005	BCAT1/ACO2/AADAT	0.198232256043247
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	3/764	33/9376	1.11565920990005	BET1/STX18/VAMP7	0.198232256043247
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	13/764	160/9376	0.997120418848168	VCAN/ITGB8/PTPRC/HLA-C/CLDN7/NEO1/SDC3/NCAM1/HLA-DMB/ITGA9/HLA-DRA/PTPRF/CDH2	-0.0109420422520429
NA	NA	hsa03272	Virion - Hepatitis viruses	4/764	48/9376	1.02268760907504	CHMP1A/CHMP1B/CLDN7/HSPG2	0.046934844920409
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	7/764	86/9376	0.998904176305857	CREB3L2/ADCY3/GNAQ/CACNA1D/PRKCA/PLCB1/ADCY1	-0.00304062150075713
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	6/764	75/9376	0.981780104712042	TSC2/RRM2B/AIFM2/GADD45G/MDM2/CASP8	-0.0471836999133721
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	4/764	50/9376	0.981780104712042	OAT/SAT1/LAP3/CNDP2	-0.0384736580072221
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	4/764	50/9376	0.981780104712042	IL15/HLA-DMB/CXCR4/HLA-DRA	-0.0384736580072221
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/764	37/9376	0.995047403424367	GNAQ/PRKCA/PLCB1	-0.0089900878221645
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/764	24/9376	1.02268760907504	XYLT1/EXTL3	0.0331453347129605
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	6/764	76/9376	0.968861945439515	CPT1A/CPT2/HMGCS1/SLC27A4/SCD5/ME3	-0.0811777676134583
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	12/764	154/9376	0.956279322771469	BCAT1/MTHFD2/NAPRT/PDXP/PTS/MTHFD1/UGT2B7/AK3/PPCDC/FPGS/COX15/HAAO	-0.162935226583083
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	3/764	38/9376	0.968861945439515	GALK2/HK1/GALT	-0.057284436547168
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/764	38/9376	0.968861945439515	INSR/PRKCA/PIK3R1	-0.057284436547168
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	14/764	181/9376	0.949234907870759	STAT1/PPP3CA/PPP3R1/TCIRG1/MAPK10/AKT3/CD74/JAK2/HLA-DMB/MAPK9/AKT2/HLA-DRA/CREBBP/CASP8	-0.205404004507028
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	4/764	52/9376	0.944019331453887	ADCY3/INSR/STAR/ADCY1	-0.120564354978291
Human Diseases	Immune disease	hsa05330	Allograft rejection	3/764	39/9376	0.944019331453887	HLA-C/HLA-DMB/HLA-DRA	-0.104339082082666
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	8/764	105/9376	0.935028671154326	MITF/MAPK10/MAPK9/TBK1/TOMM70/PGAM5/USP8/OPA1	-0.199403793104791
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	5/764	66/9376	0.92971600825004	STAT1/RORA/MAF/HLA-DMB/HLA-DRA	-0.170660829929076
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/764	26/9376	0.944019331453887	ABCD4/ABCC1	-0.0851332584419261
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/764	12/9376	1.02268760907504	NCAM1	0.0234222686391865
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	4/764	54/9376	0.90905565251115	BCAT1/ENOPH1/DNMT1/CTH	-0.199617378945773
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/764	27/9376	0.90905565251115	HMGCS1/OXCT1	-0.140946832499263
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	3/764	41/9376	0.897969607968331	MMP2/MDM2/MAP2K1	-0.195004498225771
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/764	42/9376	0.87658937920718	GCDH/AADAT/HAAO	-0.238739121142649
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/764	28/9376	0.87658937920718	PTS/FPGS	-0.194783653574612
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	5/764	70/9376	0.87658937920718	MGST1/GSTT2B/SULT1A1/GSTA4/UGT2B7	-0.308674206061075
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	3/764	43/9376	0.856203579690734	PLPP3/ABCA1/SLC27A4	-0.281482873972002
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	23/764	308/9376	0.916434350989325	MT-ND3/MT-CO3/TGM2/MT-CO2/CREB3L2/TUBB/GNAQ/PLCB1/MTOR/MAP2K7/ATG13/MT-CO1/MAPK10/PPIF/DNAH14/MAPK9/PSMD11/ULK2/AP2A2/GRIA1/REST/CREBBP/CASP8	-0.444147988833688
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	7/764	99/9376	0.86773494103337	ITGB8/LAMA2/CACNA1D/SLC8A1/PRKAG2/ITGA9/PRKAA1	-0.394039043150739
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	3/764	44/9376	0.836744407425036	XRCC1/POLB/MUTYH	-0.323286334954071
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	3/764	44/9376	0.836744407425036	HLA-C/HLA-DMB/HLA-DRA	-0.323286334954071
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	3/764	44/9376	0.836744407425036	CREB3L2/ADCY3/DYNC1LI2	-0.323286334954071
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	3/764	45/9376	0.818150087260035	HLA-C/HLA-DMB/HLA-DRA	-0.364196330820662
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	6/764	87/9376	0.846362159234519	MT-CO3/MT-CO2/CACNA1D/SLC8A1/MT-CO1/ASPH	-0.428798884332367
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/764	31/9376	0.791758148961324	PFKL/PGD	-0.345891202743697
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/764	31/9376	0.791758148961324	CNDP2/HIBCH	-0.345891202743697
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/764	16/9376	0.767015706806283	NAGA	-0.277797937879355
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	8/764	117/9376	0.839128294625677	ARID1B/SS18/ACTR8/MTA1/GATAD2B/BCL7B/CHD4/BICRAL	-0.521519872025218
Human Diseases	Immune disease	hsa05310	Asthma	2/764	32/9376	0.767015706806283	HLA-DMB/HLA-DRA	-0.393201825026696
Organismal Systems	Digestive system	hsa04976	Bile secretion	6/764	90/9376	0.818150087260035	ADCY3/SCTR/ABCC4/UGT2B7/ADCY1/SLC4A2	-0.516297852886602
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	7/764	105/9376	0.818150087260035	CCL4/CCL4L2/BIRC3/CHUK/IL1R1/GADD45G/IKBKB	-0.558116372565749
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	7/764	105/9376	0.818150087260035	ADCY3/ITGB8/LAMA2/CACNA1D/SLC8A1/ITGA9/ADCY1	-0.558116372565749
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	9/764	133/9376	0.830453096091013	PPP3CA/PRKCA/HLA-C/PIK3R1/PPP3R1/PAK1/GRB2/CD247/MAP2K1	-0.586529033004202
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	5/764	78/9376	0.786682776211572	SERPING1/C1S/MAPK10/FOS/MAPK9	-0.563454381361518
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	5/764	78/9376	0.786682776211572	STAT1/FOS/JAK2/HLA-DMB/HLA-DRA	-0.563454381361518
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	5/764	79/9376	0.776724766386109	ATP6V1C1/DNM2/TCIRG1/ATP6V1E1/AP2A2	-0.593557763175215
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/764	18/9376	0.681791739383362	GLB1	-0.40247275696814
NA	NA	hsa04382	Cornified envelope formation	15/764	217/9376	0.848312302458562	S100A6/PCSK6/KRT8/PPP2R1A/BLMH/CLDN7/PPP2R2D/SLC27A4/S100A4/UGCG/EPHX2/PPP2R5D/S100A9/CAPN1/DST	-0.673343238732155
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	2/764	36/9376	0.681791739383362	MCM3/MCM7	-0.569730630124039
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	4/764	67/9376	0.73267171993436	PFKL/HK1/GALM/ADPGK	-0.654050221909776
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4/764	68/9376	0.721897135817678	ALDH1A2/ALDH1A3/CYP26A1/UGT2B7	-0.685507226874757
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	3/764	54/9376	0.681791739383362	REV3L/REV1/WDR48	-0.698448014605574
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	3/764	54/9376	0.681791739383362	HLA-C/HLA-DMB/HLA-DRA	-0.698448014605574
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	2/764	38/9376	0.645907963626343	PTPRC/TAP2	-0.651420362505405
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	6/764	100/9376	0.736335078534031	MME/HLA-DMB/TFRC/IL1R1/HLA-DRA/FLT3LG	-0.789500284995917
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	22/764	323/9376	0.835880894104679	MARCKS/PDGFRB/PDGFRA/PRKCA/HOXD10/PIK3R1/MMP16/BCL2L2/RPTOR/MTOR/DNMT1/ABL1/FZD3/APC/GRB2/ABCC1/SIRT1/TNC/MDM2/MAP2K1/CREBBP/IKBKB	-0.894014268486286
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	7/764	116/9376	0.740566889330204	ACO2/PFKL/HK1/HIBCH/PGD/ADPGK/ME3	-0.837392778240386
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	3/764	56/9376	0.657442034405385	HSF1/RAB1A/CASP8	-0.765773679323851
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/764	22/9376	0.557829604950024	CNDP2	-0.618418717998673
Genetic Information Processing	Transcription	hsa03040	Spliceosome	16/764	243/9376	0.8080494688988	PCBP1/TRA2A/SRSF7/SF1/DDX5/FUS/NCBP1/SART1/U2AF2/BUD13/RBMXL1/USP39/EFTUD2/DHX8/PRPF40B/SNRPA	-0.902954845696096
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	5/764	88/9376	0.69728700618753	SERPING1/C1S/TFPI/PLAUR/C7	-0.849750840583068
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4/764	73/9376	0.672452126515097	MGST1/GSTT2B/GSTA4/UGT2B7	-0.83676789855092
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/764	41/9376	0.598646405312221	GCAT/CTH	-0.767082775874341
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	2/764	41/9376	0.598646405312221	BARD1/UIMC1	-0.767082775874341
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	2/764	41/9376	0.598646405312221	GABRA2/GRIA1	-0.767082775874341
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/764	23/9376	0.53357614386524	MSH3	-0.667036367723954
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/764	23/9376	0.53357614386524	MME	-0.667036367723954
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	18/764	275/9376	0.803274631128034	MT-ND3/MT-CO3/MT-CO2/CREB3L2/TUBB/PPP3CA/CACNA1D/PIK3R1/PPP3R1/C7/MT-CO1/MAPK10/CCL5/PPIF/NCAM1/MAPK9/PSMD11/ITPR2	-0.986194247510512
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	4/764	75/9376	0.654520069808028	BCAT1/ACO2/PFKL/CTH	-0.894682493759689
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	8/764	138/9376	0.711434858486987	MT-ND3/MT-CO3/MT-CO2/ATP6V1C1/TCIRG1/MT-CO1/ATP6V1E1/COX15	-1.01712595924438
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4/764	79/9376	0.621379813108887	MGST1/GSTT2B/GSTA4/UGT2B7	-1.00652879222915
NA	NA	hsa04082	Neuroactive ligand signaling	12/764	199/9376	0.740035254808072	ADCY3/GNAQ/GNB2/GABRA2/PRKCA/PLCB1/GNB1/P2RY14/ADCY1/GRIA1/P2RX4/GNB4	-1.1040047320656
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	3/764	63/9376	0.584392919471453	UVSSA/POLR2M/CDK7	-0.985799782519706
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/764	46/9376	0.53357614386524	UGT2B7/COX15	-0.944493897027169
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	2/764	46/9376	0.53357614386524	PSMB9/PSMD11	-0.944493897027169
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/764	28/9376	0.43829468960359	ELOVL5	-0.886560750512327
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/764	29/9376	0.423181079617259	GNB1	-0.92657948802771
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/764	30/9376	0.409075043630017	ACO2	-0.965518006800066
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	2/764	50/9376	0.490890052356021	LRP1/THBS3	-1.07505129443169
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/764	31/9376	0.395879074480662	UGT2B7	-1.00344917454518
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/764	31/9376	0.395879074480662	ACO2	-1.00344917454518
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	16/764	268/9376	0.73267171993436	MT-ND3/MT-CO3/MT-CO2/TUBB/SLC39A14/KEAP1/UBA1/MT-CO1/MAPK10/SNCAIP/DUSP1/PPIF/SLC39A10/MAPK9/PSMD11/ITPR2	-1.32245559147829
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	18/764	298/9376	0.741276924698689	CCL4/CCL3/IL15/PRLR/XCL2/XCL1/CCL3L1/ACVR2A/CCL4L2/GDF11/CCL5/IL17RC/ACKR3/CXCR4/IL1R1/IL2RB/BMP8A/ACVR2B	-1.35185002860704
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/764	32/9376	0.383507853403141	HIBCH	-1.04043853700884
NA	NA	hsa04081	Hormone signaling	12/764	219/9376	0.672452126515097	PRLR/ADCY3/GNAQ/GNB2/INSR/STK11/PIK3R1/PLCB1/GNB1/JAK2/ADCY1/GNB4	-1.4608329008678
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/764	36/9376	0.340895869691681	UGT2B7	-1.18008190846533
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/764	36/9376	0.340895869691681	GALNT11	-1.18008190846533
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/764	37/9376	0.331682467808122	ASRGL1	-1.21314813668808
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/764	37/9376	0.331682467808122	HGD	-1.21314813668808
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	10/764	195/9376	0.629346220969258	PRKCA/PIK3R1/CLCN3/PLCB1/MTOR/AKT3/HDAC7/PPIF/AKT2/MAP2K1	-1.55783354481226
Cellular Processes	Cell motility	hsa04814	Motor proteins	9/764	194/9376	0.5693312462892	TUBB/MYH9/KIF13A/KIF3B/DNAH14/MYO1B/DYNC1LI2/MYO19/TUBG2	-1.80532705747106
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/764	47/9376	0.261111729976607	ME3	-1.51248285890589
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/764	49/9376	0.250454108344909	CREB3L2	-1.56677122445005
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	8/764	183/9376	0.536491860498384	NVL/WDR75/REXO1/NXT1/RCL1/WDR36/EMG1/NXT2	-1.88596916011681
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	3/764	99/9376	0.371886403300016	C1S/HLA-DMB/HLA-DRA	-1.8712521853264
Human Diseases	Substance dependence	hsa05034	Alcoholism	8/764	191/9376	0.514020997231436	CREB3L2/GNB2/GNB1/HDAC7/GRB2/CAMKK2/MAP2K1/GNB4	-2.02104003103621
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/764	86/9376	0.285401193230245	GABRA2/PLCB1	-1.98282306532702
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/764	63/9376	0.194797639823818	EPHX2	-1.90990083839901
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/764	66/9376	0.185943201650008	UGT2B7	-1.97666076380607
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	4/764	143/9376	0.343279756892322	C1S/C7/HLA-DMB/HLA-DRA	-2.3569876736118
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	10/764	370/9376	0.331682467808122	CALCRL/EDNRA/PRLR/SCTR/GZMA/GABRA2/P2RY14/GRIA1/S1PR2/P2RX4	-3.90659195969943
Genetic Information Processing	Translation	hsa03010	Ribosome	2/764	222/9376	0.110560822602707	MRPL30/MRPL39	-3.99454754888479
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	5/764	449/9376	0.136662041301788	ADCY3/SLC8A1/GNB1/ARRB1/GRK3	-5.58382175138146