category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	23/257	180/9376	4.66165153480329	BST2/OAS2/OAS1/STAT1/B2M/EIF2AK2/SRSF7/OAS3/IRF9/HLA-A/HLA-C/AKT3/BIRC3/CCL5/IFIH1/CD74/SP100/PPP1CB/IFNG/HLA-B/ZC3HAV1/HLA-F/HLA-DPB1	8.32707305977664
Human Diseases	Infectious disease: viral	hsa05162	Measles	18/257	136/9376	4.82856488899062	MX1/OAS2/OAS1/STAT1/EIF2AK2/OAS3/IRF9/CDK6/FOS/MAPK10/AKT3/MX2/IFIH1/HSPA1A/ADAR/HSPA1B/IL2RB/IL2RG	7.55001949072678
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	22/257	227/9376	3.53574795591285	CCL4/B2M/CREB3L2/CDK6/HLA-A/HLA-C/CCL3/AKT3/CCL5/GNAQ/CCL3L1/PTK2/HLA-B/CCL4L2/PPP3CA/PLCB1/CXCR4/HLA-F/RAC2/GNAS/GNAI1/ITPR2	6.49248254761453
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	27/257	333/9376	2.95803975181407	ISG15/COL1A1/MX1/COL1A2/COL6A1/STAT1/EIF2AK2/CREB3L2/IRF9/CDK6/LAMA2/HLA-A/HLA-C/AKT3/MX2/MAML2/ITGB8/COL6A3/PTK2/HLA-B/FZD6/PDGFRB/HLA-F/GNAS/ATP6V1G1/ITGA4/CSNK1A1	6.10753476720709
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	18/257	173/9376	3.79586603990014	MX1/OAS2/OAS1/STAT1/EIF2AK2/OAS3/IRF9/CDK6/AKT3/MX2/RSAD2/CCL5/IFIH1/ADAR/RAB11A/IFNG/ACTB/HLA-DPB1	6.2309360145239
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	16/257	139/9376	4.19942334070487	FKBP5/CREB3L2/NCOA2/FOS/GREB1/AKT3/KRT18/HSPA1A/GNAQ/NCOA1/HSPA1B/PLCB1/HSP90AA1/GNAS/GNAI1/ITPR2	6.37958207487746
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	18/257	205/9376	3.20334060928158	ISG15/OAS2/OAS1/STAT1/B2M/EIF2AK2/OAS3/IRF9/CDK6/HLA-A/HLA-C/MAPK10/AKT3/HLA-B/RUNX3/CD247/HLA-F/HLA-DPB1	5.35462195958704
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	11/257	82/9376	4.89399259751352	B2M/HLA-A/HLA-C/CD74/HSPA1A/IFNG/HLA-B/HSPA1B/HLA-F/HSP90AA1/HLA-DPB1	5.94537572705694
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	12/257	103/9376	4.25038721619886	FOS/MAPK10/CCL3/AKT3/CCL5/GNAQ/CCL3L1/IFNG/PLCB1/CD247/GNAS/GNAI1	5.56829423355055
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	15/257	156/9376	3.50793175695899	MX1/OAS2/OAS1/STAT1/PIAS1/IFIT1/EIF2AK2/OAS3/IRF9/CDK6/YWHAZ/AKT3/MX2/RSAD2/IFNG	5.30262781326214
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	11/257	93/9376	4.31513325802268	STAT1/FOS/MAPK10/MAML2/IFNG/RUNX3/PPP3CA/CD247/IL2RB/IL2RG/HLA-DPB1	5.39357697804744
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	16/257	193/9376	3.02445515211387	CCL4/STAT1/CCL3/AKT3/XCL2/CCL5/GNAQ/XCL1/CCL3L1/PTK2/CCL4L2/PLCB1/CXCR4/RAC2/ELMO1/GNAI1	4.77060121680409
Human Diseases	Immune disease	hsa05330	Allograft rejection	7/257	39/9376	6.54813927965679	HLA-A/HLA-C/IFNG/HLA-B/GZMB/HLA-F/HLA-DPB1	5.82847007634205
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	17/257	214/9376	2.89814175060911	BST2/B2M/FOS/HLA-A/HLA-C/MAPK10/AKT3/GNAQ/PTK2/HLA-B/PPP3CA/CD247/CXCR4/HLA-F/RAC2/GNAI1/ITPR2	4.71540475155686
NA	NA	hsa04518	Integrin signaling	14/257	154/9376	3.31659002476123	COL1A1/COL1A2/COL6A1/LAMA2/AKT3/ITGB8/COL6A3/PTK2/PDGFRB/RAC2/FREM2/ACTB/ITGA4/ITGB2	4.8660388886761
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	11/257	100/9376	4.01307392996109	CCL4/CCL3/XCL2/CCL5/XCL1/CCL3L1/CCL4L2/CXCR4/IL2RB/IL20RA/IL2RG	5.085199666681
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	11/257	103/9376	3.89618828151562	COL3A1/COL1A1/COL1A2/ELN/COL6A1/COL5A2/MME/COL6A3/SLC8A1/SLC7A8/COL14A1	4.96150994775924
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	11/257	103/9376	3.89618828151562	COL3A1/COL1A1/COL1A2/LAMA2/GNAQ/PTK2/IFNG/PLCB1/HSPB1/GNAS/ITGB2	4.96150994775924
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	9/257	70/9376	4.69060589216231	LAMA2/HLA-A/HLA-C/HLA-B/HLA-F/RAC2/ACTB/HLA-DPB1/ITGB2	5.20287939276532
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	12/257	122/9376	3.5884416661351	STAT1/CREB3L2/FOS/MAPK10/AKT3/JUNB/GNAQ/PTK2/PLCB1/GNAS/GNAI1/ITPR2	4.83094554183278
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	16/257	203/9376	2.87546721358609	COL1A1/COL1A2/COL6A1/LAMA2/MAPK10/AKT3/BIRC3/ITGB8/COL6A3/PTK2/PPP1CB/PIP5K1B/PDGFRB/RAC2/ACTB/ITGA4	4.53503236214915
Organismal Systems	Immune system	hsa04611	Platelet activation	12/257	126/9376	3.47452288308319	COL3A1/COL1A1/COL1A2/AKT3/GNAQ/PPP1CB/STIM1/PLCB1/GNAS/ACTB/GNAI1/ITPR2	4.69444734833968
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	7/257	44/9376	5.80403254333215	HLA-A/HLA-C/IFNG/HLA-B/GZMB/HLA-F/HLA-DPB1	5.36195921080593
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	7/257	45/9376	5.67505404236922	HLA-A/HLA-C/IFNG/HLA-B/GZMB/HLA-F/HLA-DPB1	5.27724661202294
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	12/257	133/9376	3.29165325765776	CREB3L2/FOS/MAPK10/AKT3/GRIA1/GNAQ/PPP1CB/PPP3CA/PLCB1/GNAS/GNAI1/ITPR2	4.46834649269393
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	16/257	224/9376	2.6058921623124	B2M/CREB3L2/FOS/HLA-A/HLA-C/MAPK10/AKT3/MSX1/HLA-B/ZFP36/PPP3CA/IL2RB/HLA-F/IL2RG/HLA-DPB1/ITGB2	4.08376717465664
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	13/257	160/9376	2.96420233463035	HLA-A/HLA-C/ITGB8/PTPRC/NTNG1/HLA-B/NRXN3/HLA-F/NCAM1/PTPRF/HLA-DPB1/ITGA4/ITGB2	4.20681654418728
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	9/257	86/9376	3.81793502850421	CTNNA2/CTNNA3/LAMA2/ITGB8/GJA1/SLC8A1/RYR2/ACTB/ITGA4	4.40708002120153
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	10/257	109/9376	3.34701745618106	CCL4/STAT1/IRF9/FOS/MAPK10/CCL3/AKT3/CCL5/CCL3L1/CCL4L2	4.1375054532964
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	10/257	109/9376	3.34701745618106	STAT1/FOS/MAPK10/IFNG/PPP3CA/CD247/IL2RB/HSP90AA1/IL2RG/HLA-DPB1	4.1375054532964
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	16/257	238/9376	2.45260438805873	ISG15/MX1/OAS2/OAS1/STAT1/EIF2AK2/OAS3/IRF9/FOS/MAPK10/MX2/IFIH1/RPS29/ADAR/C1S/RPS27	3.81056036095588
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	10/257	112/9376	3.25736520289049	STAT1/LAMA2/MAPK10/AKT3/BIRC3/HSPA1A/IFNG/HSPA1B/HLA-DPB1/GNAI1	4.0345040549593
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	14/257	196/9376	2.6058921623124	STAT1/EIF2AK2/IRF9/CDK6/FOS/HLA-A/HLA-C/MAPK10/AKT3/HLA-B/ZFP36/PPP3CA/HLA-F/ITPR2	3.81418422463681
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	10/257	116/9376	3.14504226485979	CTNNA2/CTNNA3/PTK2/CXCR4/RAC2/TXK/ACTB/GNAI1/ITGA4/ITGB2	3.90245538808048
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	11/257	138/9376	2.90802458692833	FOS/MAPK10/AKT3/GNAQ/PTK2/BAIAP2/PIP5K1B/RAC2/ELMO1/ACTB/ITGA4	3.79064507902026
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	20/257	362/9376	2.0156071973687	COL1A1/COL1A2/COL6A1/CREB3L2/CDK6/YWHAZ/LAMA2/MAGI2/AKT3/PRLR/ITGB8/COL6A3/ERBB4/PTK2/PDGFRB/IL2RB/HSP90AA1/IL2RG/ITGA4/IL7	3.30826180105934
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	14/257	216/9376	2.36460585098717	ABCA1/FOS/MAPK10/CCL3/AKT3/CCL5/HSPA1A/CCL3L1/PTK2/PPP3CA/HSPA1B/PLCB1/MIB1/HSP90AA1	3.40615933556053
Organismal Systems	Endocrine system	hsa04924	Renin secretion	7/257	69/9376	3.70112220154514	EDNRA/GNAQ/PPP3CA/PLCB1/GNAS/GNAI1/ITPR2	3.78044142142318
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	8/257	89/9376	3.27932496830324	COL1A1/COL1A2/COL6A1/LAMA2/ITGB8/COL6A3/FREM2/ITGA4	3.6269546090091
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	8/257	89/9376	3.27932496830324	TUBB/GNAQ/GJA1/PLCB1/PDGFRB/GNAS/GNAI1/ITPR2	3.6269546090091
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	10/257	130/9376	2.8063454055672	COL3A1/COL1A1/COL1A2/CREB3L2/FOS/MAPK10/AKT3/PLCB1/GNAS/GNAI1	3.48156191077054
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	6/257	54/9376	4.05361003026373	HLA-A/HLA-C/HLA-B/GZMB/HLA-F/HLA-DPB1	3.77776115035395
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	10/257	133/9376	2.74304438138147	HLA-A/HLA-C/IFNG/HLA-B/GZMB/PPP3CA/HCST/CD247/RAC2/ITGB2	3.39864952175016
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	12/257	178/9376	2.45949372622743	SFRP4/MAPK10/TLE1/APCDD1/DKK1/DAAM1/PPP3CA/PLCB1/FZD6/RAC2/TLE4/CSNK1A1	3.30022935549471
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	11/257	157/9376	2.5560980445612	SNAI2/CTNNA2/CTNNA3/YWHAZ/BIRC3/BMP8A/PPP1CB/FZD6/LIMD1/ACTB/ITGB2	3.30083235544072
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	8/257	93/9376	3.1382787331074	SNAI2/CTNNA2/CTNNA3/BAIAP2/RAC2/PTPRF/ACTB/PTPN1	3.47888608086162
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	9/257	115/9376	2.85515141262054	CREB3L2/MMP16/FOS/GNAQ/PLCB1/GNAS/NR4A2/GNAI1/ITPR2	3.36029906777039
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	8/257	95/9376	3.07220970714725	FOS/CCL3/CCL5/CCL3L1/IFNG/HLA-DPB1/ATP6V1G1/ITGB2	3.40782050783629
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	14/257	232/9376	2.20152958540185	AKT3/ITGB8/PTK2/PPP1CB/BAIAP2/PIP5K1B/PDGFRB/CXCR4/RAC2/DIAPH2/ACTB/ITGA4/ITGB2/IQGAP2	3.11092072866555
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	14/257	233/9376	2.1920809605718	COL3A1/COL1A1/COL1A2/ELN/COL6A1/NID1/COL5A2/LAMA2/ITGB8/COL6A3/DAAM1/DIAPH2/ACTB/ITGA4	3.09327081692572
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	8/257	97/9376	3.00886517710297	FOS/GRIA1/GNAQ/RASD1/PLCB1/RYR2/GNAS/GNAI1	3.33860210051734
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	7/257	78/9376	3.27406963982839	CTNNA2/CTNNA3/ARHGAP10/PTK2/SEPTIN2/ELMO1/ACTB	3.38559404849995
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	10/257	142/9376	2.56918945580095	FOS/MAPK10/AKT3/PTK2/IFNG/MGST1/KLF2/RAC2/HSP90AA1/ACTB	3.16302926642592
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	8/257	99/9376	2.94808002200998	DGKB/FOS/MAPK10/AKT3/PLPP3/PIP5K1B/PDGFRB/RAC2	3.27114054160509
Organismal Systems	Nervous system	hsa04730	Long-term depression	6/257	60/9376	3.64824902723735	GRIA1/GNAQ/PLCB1/GNAS/GNAI1/ITPR2	3.4546042160087
Organismal Systems	Digestive system	hsa04978	Mineral absorption	6/257	61/9376	3.5884416661351	MT1G/MT1E/MT2A/TRPM6/SLC8A1/MT1F	3.40479102860309
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	11/257	168/9376	2.3887344821197	STAT1/PIAS1/IRF9/AKT3/PRLR/IFNG/PDGFRB/IL2RB/IL20RA/IL2RG/IL7	3.04908686210297
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	8/257	102/9376	2.86137178606851	SCTR/SLC12A2/GNAQ/RAB11A/PLCB1/RYR2/GNAS/ITPR2	3.17305981398863
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	6/257	62/9376	3.53056357474583	ATXN1/TLE1/MAML2/NUMB/DTX3L/TLE4	3.35601252057424
NA	NA	hsa04519	Cadherin signaling	20/257	404/9376	1.80606387486998	CTNNA2/LHFPL3/CTNNA3/YWHAZ/PCDH7/PCDH9/MAPK10/KRT8/KRT18/GJA1/PTK2/PPP1CB/DAAM1/PCDH20/FZD6/PDGFRB/RAC2/LIMD1/ACTB/CSNK1A1	2.78031562286663
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	8/257	107/9376	2.72766282410269	CREB3L2/AKT3/GNAQ/PPP3CA/PLCB1/GNAS/ITPR2/PFKM	3.01726203305595
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	10/257	154/9376	2.36899287482945	FOS/GNAQ/PPP1CB/PPP3CA/PLCB1/RYR2/GNAS/ACTB/GNAI1/ITPR2	2.875594082698
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	6/257	67/9376	3.26708868110808	GRIA1/GNAQ/PPP1CB/PPP3CA/PLCB1/ITPR2	3.12631681759731
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	3/257	17/9376	6.43808651865415	PCDH7/PCDH9/PCDH20	3.76733674807359
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	10/257	157/9376	2.32372549505564	ZFP36L1/CDK6/HLA-A/HLA-C/AKT3/PPP1CB/HLA-B/PPP3CA/HLA-F/ITPR2	2.80791815083448
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	6/257	69/9376	3.17239045846726	CREB3L2/FOS/GRIA1/PPP1CB/PPP3CA/GNAS	3.04043810679733
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	6/257	71/9376	3.08302734696114	STAT1/FOS/MAPK10/AKT3/PRLR/LHCGR	2.95763481138421
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	8/257	115/9376	2.53791236677381	CREB3L2/FOS/AKT3/GNAQ/PLCB1/GNAI1/ITPR2/KCNQ5	2.78567315704039
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	11/257	187/9376	2.14602883955138	OAS2/OAS1/STAT1/OAS3/IRF9/MAPK10/BIRC3/CCL5/PLCB1/HSP90AA1/ITPR2	2.65742377528052
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	5/257	53/9376	3.44174436531826	GNAQ/SLC8A1/RAB11A/PLCB1/GNAS	2.99253252200797
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	10/257	166/9376	2.19774037785383	EDNRA/CREB3L2/AKT3/GNAQ/SLC8A1/PPP1CB/PPP3CA/PLCB1/GNAI1/ITPR2	2.61375882122199
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	9/257	142/9376	2.31227051022086	STAT1/IRF9/FOS/MAPK10/AKT3/JUNB/IFNG/PPP3CA/ITPR2	2.64515544248136
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	15/257	298/9376	1.8363669600188	CCL4/CCL3/PRLR/XCL2/CCL5/XCL1/CCL3L1/BMP8A/IFNG/CCL4L2/CXCR4/IL2RB/IL20RA/IL2RG/IL7	2.46313663056306
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	9/257	144/9376	2.28015564202335	ATXN1/MAPK10/AKT3/GRIA1/GNAQ/PLCB1/PUM2/ITPR2/PUM1	2.5988111103097
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	6/257	76/9376	2.88019660045054	GNAQ/PLCB1/GNAS/ACTB/GNAI1/ITPR2	2.76278555700879
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	3/257	21/9376	5.21178432462479	ENPP3/ENPP1/BCAT1	3.2436386551855
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	7/257	99/9376	2.57957001925873	MAPK10/GNAQ/PPP1CB/PLCB1/PRKCH/GNAS/ITPR2	2.65235281401326
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	8/257	122/9376	2.39229444409007	STAT1/NCOA2/AKT3/MED12L/NCOA1/PLCB1/ACTB/PFKM	2.59851273667622
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	6/257	78/9376	2.8063454055672	FOS/MAPK10/SERPING1/C1S/GNAI1/ITGB2	2.68925460659376
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	6/257	78/9376	2.8063454055672	STAT1/FOS/IFNG/HLA-DPB1/ITGA4/ITGB2	2.68925460659376
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	13/257	250/9376	1.89708949416342	HLA-A/HLA-C/HSPA1A/EPS15/RAB11A/HLA-B/HSPA1B/PIP5K1B/CXCR4/IL2RB/HLA-F/IL2RG/CHMP1B	2.41348239260865
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	7/257	101/9376	2.52848942481797	COL3A1/COL1A1/COL1A2/STAT1/MAPK10/AKT3/PLCB1	2.59265516867071
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	12/257	226/9376	1.93712337729417	EDNRA/CREB3L2/FOS/MAPK10/AKT3/GRIA1/PPP1CB/RAC2/LHCGR/RYR2/GNAS/GNAI1	2.3939718336219
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	13/257	254/9376	1.86721406905849	EDNRA/ERBB4/GNAQ/SLC8A1/PPP3CA/STIM1/PLCB1/PDGFRB/CXCR4/LHCGR/RYR2/GNAS/ITPR2	2.35221346275097
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	5/257	60/9376	3.04020752269779	AKT3/PTK2/PPP3CA/HSPB1/RAC2	2.6614224859348
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	11/257	204/9376	1.9671931029221	COL1A1/COL1A2/AKT3/ERBB4/DDX5/PTK2/PPP1CB/FZD6/HOXD10/ACTB/ITPR2	2.34463283986258
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	7/257	105/9376	2.43216601815824	LAMA2/ITGB8/SLC8A1/RYR2/GNAS/ACTB/ITGA4	2.4774409723827
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	11/257	205/9376	1.95759703900541	EIF2AK2/CREB3L2/IRF9/CDK6/YWHAZ/HLA-A/HLA-C/SP100/HLA-B/HLA-F/HNRNPK	2.32717997022067
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	11/257	205/9376	1.95759703900541	MT-ND3/COL3A1/COL1A1/COL1A2/MT-CO3/MAPK10/AKT3/PPP1CB/PLCB1/RAC2/RYR2	2.32717997022067
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	9/257	154/9376	2.13209358734651	CREB3L2/AKT3/GNAQ/SLC8A1/PPP1CB/PLCB1/RYR2/GNAS/GNAI1	2.37798288120347
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	9/257	155/9376	2.1183381448475	TUBB/HLA-A/HLA-C/HLA-B/HLA-F/ACTB/HLA-DPB1/ATP6V1G1/ITGB2	2.35683168622793
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	9/257	155/9376	2.1183381448475	CREB3L2/CDK6/GNAQ/RASD1/PLCB1/FZD6/GNAS/GNAI1/ITPR2	2.35683168622793
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	7/257	109/9376	2.34291221932674	CREB3L2/MAPK10/AKT3/PPP1CB/SREBF1/PTPRF/PTPN1	2.36739041549512
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	6/257	86/9376	2.54529001900281	CREB3L2/PCLO/GNAQ/PLCB1/RYR2/GNAS	2.4167401664063
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	8/257	134/9376	2.17805912073872	EDNRA/CALCRL/GNAQ/PPP1CB/PLCB1/PRKCH/GNAS/ITPR2	2.30576527882885
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	11/257	212/9376	1.89295940092504	MAGI2/AKT3/GNAQ/SKAP1/PLCB1/PDGFRB/RAC2/GNAS/ACTB/GNAI1/ITGB2	2.20767782818457
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	5/257	65/9376	2.8063454055672	CREB3L2/GNAQ/PLCB1/GNAS/ITPR2	2.45322796003733
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	8/257	137/9376	2.13036439546707	FOS/MAPK10/AKT3/BIRC3/GZMB/CTSW/ACTB/ITPR2	2.23740632548211
NA	NA	hsa04517	IgSF CAM signaling	14/257	299/9376	1.70821024686699	TUBB/MAPK10/MAGI2/AKT3/CADM2/PTK2/BAIAP2/SRGAP3/NCAM1/PTPRF/ACTB/APP/ITGA4/ITGB2	2.08932126534993
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	6/257	90/9376	2.43216601815824	STAT1/FOS/AKT3/IFNG/PPP3CA/CD247	2.29181138122551
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	8/257	140/9376	2.08471372984992	AKT3/GNAQ/SLC8A1/PLCB1/KLF2/RYR2/GNAI1/ITPR2	2.17077986697348
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	13/257	275/9376	1.72462681287584	MT-ND3/MT-CO3/CREB3L2/TUBB/MAPK10/CCL5/HSPA1A/PPP3CA/HSPA1B/NCAM1/RAC2/RYR2/ITPR2	2.04745696238454
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	7/257	116/9376	2.20152958540185	GRIA1/GNAQ/PPP3CA/PLCB1/GNAS/GNAI1/ITPR2	2.18593156941645
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	6/257	93/9376	2.35370904983055	CDK6/LAMA2/AKT3/BIRC3/PTK2/CKS1B	2.20242548273774
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	7/257	119/9376	2.14602883955138	CREB3L2/FOS/MAPK10/AKT3/BIRC3/CCL5/JUNB	2.11209032680014
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	5/257	73/9376	2.49880070358723	BST2/MX1/MX2/MLLT3/CXCR4	2.15810415002102
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	7/257	122/9376	2.09325763857881	FOS/MAPK10/AKT3/PTPRC/IFNG/PPP3CA/CD247	2.04040453538707
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	4/257	51/9376	2.86137178606851	SLC12A2/GNAS/ACTB/ATP6V1G1	2.23754813389153
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	6/257	98/9376	2.23362185341063	MARCKS/AKT3/PTPRC/PLPP3/PIP5K1B/RAC2	2.06085055714035
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	6/257	98/9376	2.23362185341063	CREB3L2/GNAQ/PLCB1/GNAS/NR4A2/ITPR2	2.06085055714035
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	6/257	99/9376	2.21106001650749	LAMA2/ITGB8/SLC8A1/RYR2/ACTB/ITGA4	2.03356508642142
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	5/257	75/9376	2.43216601815824	CREB3L2/GNAQ/PLCB1/GNAS/ITPR2	2.09044028576038
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	6/257	101/9376	2.16727664984397	CREB3L2/GNAQ/PLCB1/FZD6/GNAS/GNAI1	1.97995863782115
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	5/257	77/9376	2.36899287482945	STAT1/CDK6/MAPK10/AKT3/RAC2	2.02491603039504
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	16/257	388/9376	1.50443258855149	MT-ND3/APOE/MT-CO3/EIF2AK2/TUBB/MME/MAPK10/AKT3/GNAQ/DKK1/PPP3CA/PLCB1/FZD6/APP/ITPR2/CSNK1A1	1.70359383223218
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	6/257	105/9376	2.08471372984992	STAT1/IRF9/MAPK10/AKT3/PPP3CA/ITPR2	1.87639854846725
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	5/257	83/9376	2.19774037785383	CCL4/PCBP1/CCL5/ADAR/CCL4L2	1.83993448912481
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/257	37/9376	2.95803975181407	GNAQ/IFNG/PLCB1	2.00332204847814
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	8/257	168/9376	1.7372614415416	STAT1/EIF2AK2/IRF9/MAPK10/BIRC3/IFNG/HSP90AA1/CHMP1B	1.61872136415046
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	6/257	115/9376	1.90343427508036	GNAQ/PLCB1/GNAS/APP/GNAI1/ITPR2	1.63642133558039
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	4/257	65/9376	2.24507632445376	DGKB/LIPG/PLPP3/ABHD16A	1.69095901709417
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	4/257	65/9376	2.24507632445376	AKT3/GNAQ/PLCB1/ITPR2	1.69095901709417
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	4/257	66/9376	2.21106001650749	STAT1/IFNG/IL2RG/HLA-DPB1	1.65745362297665
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	5/257	93/9376	1.96142420819213	MAPK10/GNAQ/PLCB1/GNAS/ITPR2	1.5641951836758
Organismal Systems	Digestive system	hsa04970	Salivary secretion	5/257	93/9376	1.96142420819213	SLC12A2/GNAQ/PLCB1/GNAS/ITPR2	1.5641951836758
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/257	21/9376	3.47452288308319	XYLT1/CHSY3	1.90571440939696
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	7/257	149/9376	1.71394249601755	DGKB/AKT3/PLPP3/PLCB1/PIP5K1B/PDGFRB/GNAS	1.47470345984541
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	7/257	149/9376	1.71394249601755	MT-ND3/MAPK10/GRIA1/GNAQ/PLCB1/GNAI1/ITPR2	1.47470345984541
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4/257	68/9376	2.14602883955138	ALDH1A2/UGT2B7/CYP26A1/ALDH1A3	1.59221022193008
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	3/257	44/9376	2.48744251857092	CREB3L2/RAB11A/GNAS	1.6601898594683
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	8/257	181/9376	1.61248575789496	STAT1/MAPK10/AKT3/CD74/IFNG/PPP3CA/HLA-DPB1/ITGB2	1.39681216011966
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	6/257	125/9376	1.75115953307393	MAPK10/AKT3/GNAQ/PLCB1/RAC2/GNAI1	1.41929097554234
Genetic Information Processing	Transcription	hsa03040	Spliceosome	10/257	243/9376	1.50133704824582	PCBP1/SRSF7/TRA2A/HSPA1A/DDX5/HSPA1B/PRPF4/HNRNPK/SF1/SNRNP27	1.32924427854693
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	5/257	98/9376	1.86135154450885	DGKB/PLCB1/PIP5K1B/ITPR2/IP6K2	1.43894727990353
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	8/257	184/9376	1.58619522923363	PTK2/NTNG1/PPP3CA/SRGAP3/CXCR4/RAC2/EPHA6/GNAI1	1.34810827739316
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	4/257	72/9376	2.02680501513186	ISG15/MAPK10/IFIH1/ADAR	1.46824310676695
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	5/257	99/9376	1.84255001375624	FOS/MAPK10/AKT3/PTK2/GNAS	1.41477735882958
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	5/257	100/9376	1.82412451361868	MME/CD37/HLA-DPB1/ITGA4/IL7	1.39088445865364
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	10/257	248/9376	1.47106815614409	TUBB/FOS/MAPK10/AKT3/BIRC3/PTPRC/EXOC4/HSP90AA1/ELMO1/ACTB	1.26211917230768
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	3/257	49/9376	2.23362185341063	CREB3L2/GNAS/GNAI1	1.45340850708448
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	3/257	50/9376	2.18894941634241	OAT/SAT1/GOT1	1.41507437522164
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	3/257	50/9376	2.18894941634241	CXCR4/HLA-DPB1/ITGA4	1.41507437522164
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	7/257	163/9376	1.56673271108353	STAT1/CREB3L2/YWHAZ/FOS/MAPK10/AKT3/IFIH1	1.2253217398936
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	2/257	27/9376	2.70240668684248	ELOVL5/FADS2	1.48710355104001
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	3/257	52/9376	2.1047590541754	APOE/LIPG/ABCA1	1.34105534352362
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	6/257	138/9376	1.58619522923363	MAPK10/AKT3/PPP1CB/SREBF1/PTPRF/PTPN1	1.16458565380274
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	7/257	170/9376	1.50222018768597	ARID1B/CDK6/AKT3/FZD6/MGST1/ACTB/CSNK1A1	1.10933249176867
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	3/257	56/9376	1.9544191217343	HSPA1A/HSPA1B/ITGB2	1.20255176799013
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	11/257	300/9376	1.33769130998703	FOS/MAPK10/AKT3/ERBB4/HSPA1A/MAP3K20/PPP3CA/HSPA1B/HSPB1/PDGFRB/RAC2	0.997957073040903
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	4/257	85/9376	1.71682307164111	ENPP3/ENPP1/XDH/GMPR	1.11447107145576
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	4/257	86/9376	1.69686001266854	MAPK10/AKT3/ERBB4/PTK2	1.08984692987614
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	4/257	87/9376	1.67735587459189	FOS/MAPK10/AKT3/RAC2	1.06554216148495
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/257	32/9376	2.28015564202335	MAPK10/BIRC3	1.21772701510235
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	3/257	59/9376	1.85504187825628	AKT3/GNAS/GNAI1	1.10599696757271
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	3/257	59/9376	1.85504187825628	CTNNA2/CTNNA3/AKT3	1.10599696757271
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	6/257	148/9376	1.47901987590704	CDK6/FOS/AKT3/NCOA1/FZD6/CSNK1A1	0.986073279945026
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	4/257	88/9376	1.65829501238062	SERPING1/C1S/SERPINA5/ITGB2	1.04154823993947
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	2/257	33/9376	2.21106001650749	BCAT1/GOT1	1.16992508639902
Organismal Systems	Digestive system	hsa04976	Bile secretion	4/257	90/9376	1.62144401210549	SCTR/UGT2B7/ABCG2/GNAS	0.994460447797366
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	4/257	91/9376	1.6036259460384	FOS/AKT3/PPP3CA/RAC2	0.971351092997226
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	3/257	62/9376	1.76528178737291	AKT3/HSPA1A/HSPA1B	1.01491038827147
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	16/257	480/9376	1.21608300907912	MT-ND3/MT-CO3/TUBB/ATXN1/MAPK10/SNCAIP/GRIA1/GNAQ/DKK1/PPP3CA/PLCB1/FZD6/RYR2/APP/ITPR2/CSNK1A1	0.815872777398015
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	8/257	217/9376	1.34497659990317	CREB3L2/FOS/AKT3/UGT2B7/MGST1/HSP90AA1/GNAS/GNAI1	0.863125737254668
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	3/257	63/9376	1.7372614415416	AASS/KMT2E/PRDM6	0.985656491131278
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	4/257	94/9376	1.55244639456909	FOS/MAPK10/IFNG/HSP90AA1	0.903674193865816
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	9/257	253/9376	1.2977960966457	MAPK10/AKT3/CCL5/PTK2/PLCB1/SEPTIN2/ELMO1/ACTB/ITPR2	0.806100176265349
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/257	36/9376	2.02680501513186	ENPP3/ENPP1	1.03620190283326
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/257	37/9376	1.97202650120938	ASRGL1/GOT1	0.994505918367446
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/257	37/9376	1.97202650120938	HGD/GOT1	0.994505918367446
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/257	38/9376	1.92013106696703	ENPP3/ENPP1	0.954098361077691
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	2/257	38/9376	1.92013106696703	PTPRC/IL2RG	0.954098361077691
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/257	12/9376	3.04020752269779	NCAM1	1.18716984615906
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	8/257	227/9376	1.28572652942286	MT-ND3/MT-CO3/FOS/MAPK10/AKT3/PTK2/MGST1/PTPN1	0.73156896423507
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	4/257	99/9376	1.47404001100499	KRT18/C1S/HLA-DPB1/ITGB2	0.795989631237749
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	3/257	69/9376	1.58619522923363	MAPK10/AKT3/RAC2	0.820428162919767
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	3/257	71/9376	1.54151367348057	MAPK10/CCL5/ATP6V1G1	0.768880780112272
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	3/257	71/9376	1.54151367348057	AKT3/PDGFRB/PFKM	0.768880780112272
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	7/257	201/9376	1.27053448709759	ZBTB16/BIRC3/DDX5/PTK2/MLLT3/GZMB/IL2RB	0.650872945865377
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	8/257	235/9376	1.24195711565527	MT-ND3/ZNF516/MT-CO3/ARID1B/CREB3L2/BMP8A/GNAS/ACTB	0.630600146584061
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	2/257	42/9376	1.7372614415416	PCBP1/SAT1	0.803879326565193
Human Diseases	Cancer: specific types	hsa05218	Melanoma	3/257	73/9376	1.49928042215234	CDK6/AKT3/PDGFRB	0.718907556216326
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/257	43/9376	1.69686001266854	ABCA1/PLPP3	0.76886082158985
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	4/257	106/9376	1.3766977461273	CREB3L2/AKT3/PDGFRB/HSP90AA1	0.654763828312227
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	3/257	75/9376	1.45929961089494	BCAT1/GOT1/PFKM	0.670409992749017
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	3/257	75/9376	1.45929961089494	AKT3/BIRC3/MGST1	0.670409992749017
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/257	15/9376	2.43216601815824	ST6GALNAC5	0.931872431304141
Human Diseases	Cancer: specific types	hsa05214	Glioma	3/257	76/9376	1.44009830022527	CDK6/AKT3/PDGFRB	0.646686217406806
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/257	45/9376	1.62144401210549	ABCA1/ABCG2	0.701492063562041
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	4/257	110/9376	1.32663600990449	BMP8A/IFNG/THSD4/CHRD	0.578485993837457
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	4/257	110/9376	1.32663600990449	MAPK10/AKT3/HSP90AA1/GNAI1	0.578485993837457
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/257	16/9376	2.28015564202335	GOT1	0.860326763927019
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	2/257	46/9376	1.58619522923363	IFNG/PSMB9	0.669050601646633
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	3/257	78/9376	1.4031727027836	PLCB1/PIP5K1B/IP6K2	0.600236280875193
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	2/257	48/9376	1.5201037613489	BCAT1/ACAD8	0.606449910869673
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/257	48/9376	1.5201037613489	AKT3/PLCB1	0.606449910869673
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	3/257	82/9376	1.33472525386732	UGT2B7/XDH/MGST1	0.511060909783574
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	5/257	150/9376	1.21608300907912	CTNNA2/CTNNA3/AKT3/FZD6/CSNK1A1	0.447855709729643
NA	NA	hsa04081	Hormone signaling	7/257	219/9376	1.16610699500737	PRLR/GNAQ/NPR3/PLCB1/LHCGR/GNAS/GNAI1	0.417553341923636
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	2/257	50/9376	1.45929961089494	IFNG/ITGB2	0.546653289865044
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	2/257	52/9376	1.4031727027836	LHCGR/GNAS	0.48940708418486
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/257	20/9376	1.82412451361868	LSS	0.619357378409464
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	3/257	87/9376	1.25801690594392	MT-CO3/SLC8A1/RYR2	0.405883970261254
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	4/257	122/9376	1.19614722204503	CREB3L2/AKT3/SREBF1/PFKM	0.366079931519648
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	5/257	157/9376	1.16186274752782	ABCA1/PTK2/MEGF10/ELMO1/MERTK	0.343347127803261
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	5/257	157/9376	1.16186274752782	MT-CO3/FOS/MAPK10/AKT3/SREBF1	0.343347127803261
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	2/257	54/9376	1.35120334342124	BCAT1/GOT1	0.434489778819792
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/257	55/9376	1.32663600990449	PLPP3/PSAP	0.407842748124646
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	8/257	268/9376	1.08902956036936	MT-ND3/MT-CO3/TUBB/MAPK10/SNCAIP/GNAS/GNAI1/ITPR2	0.248238253387354
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	2/257	56/9376	1.3029460811562	GPR161/CSNK1A1	0.381706880346313
NA	NA	hsa04082	Neuroactive ligand signaling	6/257	199/9376	1.09997458107659	P2RY14/GRIA1/GNAQ/PLCB1/GNAS/GNAI1	0.239300913979599
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	2/257	57/9376	1.28008737797802	ELOVL5/FADS2	0.356061405600316
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	4/257	128/9376	1.14007782101167	ENPP3/ENPP1/XDH/GMPR	0.267873063043889
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	6/257	200/9376	1.09447470817121	TUBB/FOS/MAPK10/TMBIM6/BAIAP2/ACTB	0.226716144002915
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	9/257	308/9376	1.06604679367325	MT-ND3/MT-CO3/CREB3L2/TUBB/TGM2/MAPK10/GRIA1/GNAQ/PLCB1	0.19785632291203
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/257	23/9376	1.58619522923363	GOT1	0.472508170302194
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/257	23/9376	1.58619522923363	MME	0.472508170302194
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	2/257	59/9376	1.23669458550419	ENPP3/ENPP1	0.306164528856031
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/257	24/9376	1.5201037613489	XYLT1	0.428274245211785
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/257	26/9376	1.4031727027836	FADS2	0.345581575820825
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	5/257	174/9376	1.04834742161993	MAPK10/HSPA1A/HSPA1B/HSP90AA1/SYVN1	0.108065090049013
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	4/257	138/9376	1.05746348615575	YWHAZ/PPP1CB/PPP3CA/ITPR2	0.114161883715728
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/257	28/9376	1.3029460811562	ELOVL5	0.269502994297491
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/257	28/9376	1.3029460811562	ATP6V1G1	0.269502994297491
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	3/257	105/9376	1.04235686492496	CCL4/BIRC3/CCL4L2	0.0732712767209207
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/257	29/9376	1.25801690594392	LIMD1	0.233609033495347
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	4/257	144/9376	1.01340250756593	TRA2A/MAPK10/AKT3/SREBF1	0.027208086598987
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	2/257	68/9376	1.07301441977569	ZBTB16/AKT3	0.101440994766466
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/257	30/9376	1.21608300907912	PIGN	0.198997192831878
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/257	30/9376	1.21608300907912	ABCG2	0.198997192831878
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	2/257	70/9376	1.04235686492496	MAPK10/AKT3	0.0597131381945232
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/257	70/9376	1.04235686492496	UGT2B7/MGST1	0.0597131381945232
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/257	31/9376	1.17685452491528	PFKM	0.16557164437966
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/257	31/9376	1.17685452491528	UGT2B7	0.16557164437966
NA	NA	hsa04981	Folate transport and metabolism	1/257	31/9376	1.17685452491528	ABCG2	0.16557164437966
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	3/257	110/9376	0.994977007428369	AKT3/IFNG/PFKM	-0.00889592929661239
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/257	32/9376	1.14007782101167	PFKM	0.133246725056792
Human Diseases	Immune disease	hsa05310	Asthma	1/257	32/9376	1.14007782101167	HLA-DPB1	0.133246725056792
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/257	73/9376	0.999520281434891	UGT2B7/MGST1	-0.000690740686019758
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	2/257	73/9376	0.999520281434891	CDK6/AKT3	-0.000690740686019758
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/257	35/9376	1.04235686492496	PFKM	0.0421443864989891
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	5/257	195/9376	0.935448468522398	AKT3/PLCB1/RAC2/ACTB/ITGB2	-0.152917593324229
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	3/257	117/9376	0.935448468522398	ARID1B/BAZ2B/ACTB	-0.117949480157684
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	2/257	77/9376	0.94759714993178	CDK6/AKT3	-0.0775105357321495
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/257	36/9376	1.01340250756593	UGT2B7	0.0135251616790867
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	4/257	158/9376	0.923607348667685	AKT3/FZD6/TELO2/ATP6V1G1	-0.162569985421315
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	2/257	78/9376	0.935448468522398	PAN3/PFKM	-0.0961031610309948
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/257	79/9376	0.923607348667685	UGT2B7/MGST1	-0.114464892665349
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	3/257	120/9376	0.912062256809339	MAPK10/AKT3/KIDINS220	-0.162754444784486
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	2/257	80/9376	0.912062256809339	AKT3/PDGFRB	-0.13260223489962
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/257	39/9376	0.935448468522398	MTHFD2	-0.0678131262815967
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	2/257	83/9376	0.879096151141531	RYBP/PHF1	-0.185729032347758
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	2/257	83/9376	0.879096151141531	XDH/PEX11B	-0.185729032347758
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/257	41/9376	0.88981683591155	GRIA1	-0.11869395437472
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	6/257	250/9376	0.875579766536965	PSAP/CTSW/SUMF1/TELO2/ATP6V1G1/BLOC1S4	-0.334733652217522
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	2/257	89/9376	0.81983124207581	PLCL1/GNAI1	-0.286691856597804
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	1/257	44/9376	0.829147506190308	ALG11	-0.19069481620052
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/257	44/9376	0.829147506190308	TAF6	-0.19069481620052
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	3/257	133/9376	0.822913314414441	MAPK10/AKT3/KLF2	-0.345289876553042
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	2/257	90/9376	0.810722006052745	CREB3L2/AKT3	-0.302890485630782
Human Diseases	Substance dependence	hsa05032	Morphine addiction	2/257	91/9376	0.801812973019199	GNAS/GNAI1	-0.318921322946953
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/257	46/9376	0.793097614616816	UGT2B7	-0.236146864592737
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/257	47/9376	0.776223197284543	MAPK10	-0.258181451969514
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	3/257	138/9376	0.793097614616816	MT-ND3/MT-CO3/ATP6V1G1	-0.411050001327777
NA	NA	hsa03272	Virion - Hepatitis viruses	1/257	48/9376	0.760051880674449	CHMP1B	-0.279783624715435
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	1/257	49/9376	0.744540617803542	GXYLT2	-0.300972975042856
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	3/257	142/9376	0.770756836740286	PIAS1/BIRC3/SYVN1	-0.462087501186031
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	3/257	143/9376	0.765366928791053	IFNG/C1S/HLA-DPB1	-0.474640090643276
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/257	51/9376	0.715342946517128	PLPP3	-0.34218519029181
Human Diseases	Substance dependence	hsa05034	Alcoholism	4/257	191/9376	0.76403120989264	CREB3L2/PPP1CB/GNAS/GNAI1	-0.553108408882372
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/257	54/9376	0.675601671710621	TELO2	-0.401328064063747
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	2/257	104/9376	0.701586351391799	DGKB/PLPP3	-0.513720897779572
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	2/257	105/9376	0.694904576616639	MAPK10/MTX1	-0.527771147194524
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	7/257	323/9376	0.790642204045247	MARCKS/CDK6/MMP16/ZFPM2/PDGFRB/HOXD10/HNRNPK	-0.642795356133455
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	1/257	56/9376	0.651473040578099	ALG11	-0.439138007297501
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	8/257	368/9376	0.793097614616816	MT-ND3/MT-CO3/SRSF7/TUBB/GRIA1/ERBB4/PPP3CA/ACTB	-0.679757190519977
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	3/257	154/9376	0.710697862448835	BCAT1/UGT2B7/MTHFD2	-0.607684327763687
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	8/257	370/9376	0.788810600483752	SCTR/EDNRA/GZMA/CALCRL/PRLR/P2RY14/GRIA1/LHCGR	-0.695801880373267
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	1/257	59/9376	0.618347292752094	MGST1	-0.493667909860645
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	3/257	158/9376	0.692705511500763	CDK6/YWHAZ/TFDP2	-0.653948510021653
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	1/257	63/9376	0.579087147180532	FZD6	-0.562725055462818
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	2/257	116/9376	0.629008452971958	GOT1/PFKM	-0.674941461690281
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/257	66/9376	0.552765004126872	UGT2B7	-0.612084664779518
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	1/257	67/9376	0.54451478018468	PFKM	-0.628114424787143
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	1/257	70/9376	0.521178432462479	AKT3	-0.675024898172734
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	1/257	75/9376	0.486433203631647	CDK6	-0.749620300262343
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	1/257	76/9376	0.480032766741757	FADS2	-0.764046675661183
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	1/257	79/9376	0.461803674333842	ATP6V1G1	-0.806420297971805
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	4/257	238/9376	0.613151097014681	MAPK10/AKT3/PDGFRB/RAC2	-1.01480561914393
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	2/257	144/9376	0.506701253782966	AKT3/FZD6	-1.0014331228853
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/257	86/9376	0.424215003167134	PLCB1	-0.900492924919088
NA	NA	hsa04382	Cornified envelope formation	3/257	217/9376	0.50436622496369	KRT8/KRT18/S100A6	-1.2400674932926
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	1/257	103/9376	0.354198934683238	PPP1CB	-1.10633291015384
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	2/257	169/9376	0.431745447010338	MAPK10/AKT3	-1.2514277953472
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	2/257	170/9376	0.429205767910277	MAPK10/ACTB	-1.26080273811536
Cellular Processes	Cell motility	hsa04814	Motor proteins	2/257	194/9376	0.376108147137872	TUBB/ACTB	-1.47407685475095
Genetic Information Processing	Translation	hsa03010	Ribosome	2/257	222/9376	0.328671083534897	RPS29/RPS27	-1.69935838730361
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/257	449/9376	0.0812527622992729	SLC8A1	-3.34923053074147