category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	31/682	109/9376	3.90992493744787	HLA-DRB5/IRF4/HLA-DRA/IL21R/NFKB1/HLA-DQA1/HIF1A/CD247/HLA-DRB1/HLA-DQA2/JAK1/SMAD3/TGFBR2/STAT3/STAT1/TGFB1/IL2RB/GATA3/PRKCQ/NFKBIA/HLA-DPB1/RUNX1/MAPK8/IFNGR1/IL4R/HLA-DMA/HLA-DPA1/TBX21/STAT5B/RARA/SMAD4	8.55841735861214
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	44/682	205/9376	2.9507474429583	CD44/PIK3R1/ISG15/HLA-DRB5/TNFAIP3/HLA-DRA/HLA-C/NFKB1/EIF2AK2/BAX/HLA-DQA1/CD247/LYN/HLA-DRB1/HLA-DQA2/JAK1/CDK6/CYCS/RELB/PLCG2/MYC/OAS1/CALR/STAT3/STAT1/IRF9/MAP2K3/PSMD8/HLA-G/PDIA3/PSMD7/TAB2/NFKBIA/HLA-DPB1/CD58/MAPK8/HLA-DMA/BCL2L11/HLA-DPA1/TRAF6/NFKB2/PSMC4/IRF7/BAK1	7.90929251608638
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	38/682	180/9376	2.90231345715217	PIK3R1/HLA-DRB5/PPP1CB/BST2/HLA-DRA/SRSF2/HLA-C/CD74/NFKB1/EIF2AK2/BAX/HLA-DQA1/HLA-DRB1/HLA-DQA2/SRSF7/JAK1/CYCS/OAS1/CALR/STAT1/IFIH1/IRF9/SRSF5/HLA-G/PDIA3/BIRC2/TAB2/NFKBIA/HLA-DPB1/ALYREF/IFNGR1/HLA-DMA/HLA-DPA1/TRAF6/IRF7/PPP1CA/BAK1/SRPK1	7.21750110449732
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	37/682	173/9376	2.9402810502941	PIK3R1/HLA-DRB5/HLA-DRA/MX1/NFKB1/EIF2AK2/BAX/HLA-DQA1/KPNA2/HLA-DRB1/NUP98/HLA-DQA2/JAK1/CDK6/CYCS/MX2/PABPN1/OAS1/RAB11A/STAT1/IFIH1/IRF9/RSAD2/KPNA6/ADAR/CREBBP/NFKBIA/KPNA1/HLA-DPB1/PRKCA/IFNGR1/HLA-DMA/HLA-DPA1/RAF1/NXT1/IRF7/BAK1	7.21424671423781
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	37/682	196/9376	2.59524806990245	PIK3R1/UBC/GNG2/CTNNB1/CLEC2B/HLA-C/NFKB1/EIF2AK2/ZFP36/BAX/HIF1A/LYN/CALM1/JAK1/CSF2/CDK6/CYCS/PLCG2/MYC/STAT3/GNG4/STAT1/IRF9/HLA-G/MAP1LC3A/CALM3/GNB1/CREBBP/NFKBIA/PREX1/MAPK8/IFNGR1/GNGT2/RAF1/IRF7/GNB2/BAK1	6.32124947423208
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	16/682	46/9376	4.78184368226444	PSME2/PSME4/PSMA7/PSME1/PSMB9/POMP/PSMB1/PSMA6/PSMB6/PSMD8/PSMA2/PSMD7/PSMB3/PSMB7/PSMB10/PSMC4	7.20127963449117
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	41/682	232/9376	2.4295682070988	PIK3R1/CXCR4/ITGB2/TMSB4X/GNA13/PPP1CB/ARPC3/MYH9/CDC42/MSN/EZR/PFN1/PDGFRA/ITGA4/CFL1/ITGAE/MYL12B/RGCC/PDGFD/BRK1/F2R/IQGAP2/TIAM1/BRAF/SSH1/FN1/GNA12/PAK2/DIAPH1/GIT1/ACTN4/ACTN1/ROCK1/SOS2/PAK1/FGF10/ITGB7/RAF1/PDGFRB/NCKAP1L/PPP1CA	6.17516792983686
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	19/682	66/9376	3.95770016884386	HLA-DRB5/IL12RB2/HLA-DRA/IL21R/NFKB1/HLA-DQA1/HLA-DRB1/HLA-DQA2/SMAD3/STAT3/STAT1/TGFB1/GATA3/HLA-DPB1/IFNGR1/IL4R/HLA-DMA/HLA-DPA1/TBX21	6.75335035611114
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	23/682	93/9376	3.39999369343802	HLA-DRB5/IL12RB2/HLA-DRA/NFKB1/HLA-DQA1/CD247/HLA-DRB1/HLA-DQA2/JAK1/STAT1/IL2RB/GATA3/PRKCQ/NFKBIA/HLA-DPB1/MAPK8/IFNGR1/IL4R/HLA-DMA/HLA-DPA1/TBX21/STAT5B/JAG1	6.5144147804662
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	44/682	268/9376	2.25710158883004	NFE2L2/PSMA7/UBC/TUBA4A/ATP5F1E/NDUFB2/BAX/CALM1/UQCRB/COX7A2/COX6C/CYCS/NDUFS6/NDUFA13/EIF2AK3/ADORA2A/PSMB1/PSMA6/PSMB6/PSMD8/NDUFA6/CALM3/PSMA2/PSMD7/MT-ND6/NDUFA4/SNCAIP/UQCRQ/PARK7/TXN/PSMB3/UBE2L6/NDUFB1/MAPK8/NDUFB6/ATP5F1C/NDUFB8/ATP5MC1/NDUFA12/NDUFA11/PSMB7/UQCRFS1/COX7B/PSMC4	5.84782367145722
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	66/682	480/9376	1.89032258064516	PSMA7/UBC/TNFRSF1B/CTNNB1/TUBA4A/ATP5F1E/NDUFB2/NFKB1/BAX/ATXN1/CALM1/UQCRB/COX7A2/COX6C/CYCS/NDUFS6/NDUFA13/EIF2AK3/RAB1A/BRAF/DCTN6/PSMB1/RYR2/MAP2K3/PSMA6/PSMB6/PSMD8/NDUFA6/ATG2A/MAP1LC3A/CALM3/PSMA2/PSMD7/MT-ND6/NDUFA4/SNCAIP/VCP/UQCRQ/PARK7/PSMB3/PRKCA/UBE2L6/NDUFB1/MAPK8/AMBRA1/NDUFB6/ATP5F1C/NDUFB8/ATP5MC1/NDUFA12/NDUFA11/DKK1/CCS/TRPC3/PSMB7/UQCRFS1/CACNA1D/RAF1/COX7B/DCTN5/CSNK2B/WNT5A/PSMC4/BAK1/CSF1/RAB39B	5.60839543838489
Human Diseases	Infectious disease: viral	hsa05162	Measles	28/682	136/9376	2.83042953251682	PIK3R1/CBLB/TNFAIP3/MX1/NFKB1/EIF2AK2/BAX/MSN/JAK1/CDK6/CYCS/MX2/OAS1/STAT3/STAT1/IFIH1/IRF9/IL2RB/ADAR/TAB2/NFKBIA/MAPK8/TRAF6/STAT5B/CSNK2B/RAB9A/IRF7/BAK1	6.02219051254335
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	41/682	248/9376	2.27282187115694	ARPC3/CTNNB1/TUBA4A/CYTH1/FLNA/NFKB1/BAX/CDC42/PFN1/ARF6/HSP90B1/CYTH3/CYCS/MYL12B/PTPRC/BRK1/SNX9/MYC/DCTN6/MAP2K3/SKP1/BIRC2/TAB2/RALA/TXN/NFKBIA/KPNA1/PLEKHM2/MAPK8/DYNLT1/PAK1/TRAF6/RAF1/ELMO2/RHOH/NCKAP1L/ARL8A/DCTN5/RAB9A/PIK3C2B/BAK1	5.68949423344217
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	37/682	214/9376	2.37695617617234	PIK3R1/CXCR4/GNG2/TNFRSF1B/BST2/HLA-C/NFKB1/BAX/APOBEC3G/CD247/AP1S1/CALM1/CFL1/CYCS/PLCG2/CALR/GNG4/MAP2K3/HLA-G/PDIA3/CALM3/GNB1/SKP1/TAB2/PAK2/NFKBIA/PRKCA/MAPK8/RNF7/GNGT2/PAK1/RBX1/TRAF6/RAF1/RPS6KB1/GNB2/BAK1	5.70689482641984
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	38/682	224/9376	2.33221617092585	PIK3R1/HLA-DRB5/ITGB2/HLA-DRA/HLA-C/NFKB1/ZFP36/BAX/HLA-DQA1/HLA-DRB1/HLA-DQA2/JAK1/CSF2/SMAD3/RELB/TGFBR2/ETS1/ADCY3/MYC/CALR/TSPO/TGFB1/HLA-G/IL2RB/CREBBP/NFKBIA/RANBP1/HLA-DPB1/MAPK8/NRP1/EGR2/HLA-DMA/HLA-DPA1/STAT5B/KAT2B/NFKB2/ANAPC11/SMAD4	5.65208535883008
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	30/682	156/9376	2.64380780509813	PIK3R1/CTNNB1/MX1/YWHAZ/NFKB1/EIF2AK2/BAX/JAK1/CDK6/CYCS/MX2/MYC/OAS1/BRAF/STAT3/STAT1/IRF9/PPP2R2B/RSAD2/CD81/PPP2CA/PPP2R2D/NFKBIA/SOS2/PIAS1/TRAF6/RAF1/IRF7/BAK1/IFIT1	5.79850297710563
NA	NA	hsa04517	IgSF CAM signaling	46/682	299/9376	2.1150462440785	PIK3R1/FYN/ITGB2/ARPC3/MYL6/CTNNB1/TUBA4A/MYH9/CDC42/MSN/EZR/SH2D1A/ARF6/FOXO1/LYN/PPFIA2/ITGA4/SH2D1B/MYL12B/EPB41L3/PLCG2/CRTAM/SPTBN1/NLGN1/SLIT3/LRFN4/SLAMF7/PARD6G/PAK2/TIGIT/GIT1/PRKCQ/ACTN4/ACTN1/PRKCA/MAPK8/NRP1/ABL1/PAK1/MAGI2/RASA1/RAPGEF2/TRAF6/SPTBN4/PTPRD/PRKCI	5.48814166432435
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	53/682	368/9376	1.97998214968762	PSMA7/TNFRSF1B/TUBA4A/ATP5F1E/NDUFB2/BAX/PFN1/HNRNPA3/NUP98/SRSF7/UQCRB/COX7A2/COX6C/CYCS/NDUFS6/NDUFA13/EIF2AK3/RAB1A/DCTN6/PSMB1/MAP2K3/PSMA6/PSMB6/PSMD8/NDUFA6/ATG2A/MAP1LC3A/PSMA2/PSMD7/MT-ND6/NDUFA4/VCP/UQCRQ/PSMB3/NDUFB1/AMBRA1/NDUFB6/ATP5F1C/NDUFB8/ATP5MC1/NDUFA12/ALYREF/NDUFA11/NUP58/CCS/PSMB7/UQCRFS1/NXT1/COX7B/DCTN5/PSMC4/ANXA11/RAB39B	5.37150387419073
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	35/682	203/9376	2.37031044595005	PIK3R1/FYN/PPP1CB/IGF1/COL1A1/CTNNB1/FLNA/CDC42/COL6A1/PDGFRA/ITGA4/MYL12B/PDGFD/COL6A3/BRAF/LAMA2/COL4A2/FN1/PARVB/BIRC2/PAK2/DIAPH1/ACTN4/ACTN1/PRKCA/MAPK8/ROCK1/SOS2/LAMB1/PAK1/COL4A1/ITGB7/RAF1/PDGFRB/PPP1CA	5.52814337562553
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	35/682	205/9376	2.34718546598956	COL3A1/PIK3R1/PPP1CB/COL1A1/ATP5F1E/NDUFB2/NFKB1/UQCRB/SMAD3/COX7A2/COX6C/NDUFS6/TGFBR2/NDUFA13/RYR2/TGFB1/NDUFA6/CTSD/MT-ND6/NDUFA4/UQCRQ/GFPT1/PRKCA/NDUFB1/MAPK8/NDUFB6/ATP5F1C/NDUFB8/ATP5MC1/NDUFA12/NDUFA11/UQCRFS1/MMP2/COX7B/PPP1CA	5.46215450000686
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	40/682	250/9376	2.19964809384164	CXCR4/WIPF3/CBLB/BIN1/VPS37B/ARPC3/ARF5/HLA-C/ASAP1/CYTH1/CDC42/ARF6/CYTH3/CAPZA1/PDGFRA/SMAD3/TGFBR2/GRK5/RAB11A/EPS15/HLA-G/IL2RB/ITCH/PARD6G/GIT1/MVB12B/AP2B1/ARFGAP3/EHD4/STAM/RABEP1/TRAF6/PSD3/CHMP4A/RAB31/CHMP4B/DAB2/SNF8/SNX1/PRKCI	5.38457769685815
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	19/682	77/9376	3.3923144304376	PIK3R1/NFKB1/BAX/CDC42/JAK1/SMAD3/CDK6/TGFBR2/BRAF/STAT3/STAT1/TGFB1/RALA/TGFA/MAPK8/RAF1/RPS6KB1/BAK1/SMAD4	5.90355354021009
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	22/682	101/9376	2.99457042478441	COL3A1/PIK3R1/COL1A1/NFKB1/BAX/CDC42/FOXO1/SMAD3/PLCG2/TGFBR2/STAT3/STAT1/TGFB1/COL4A2/FN1/DIAPH1/PRKCA/MAPK8/COL4A1/MMP2/STAT5B/SMAD4	5.64444324350173
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	23/682	112/9376	2.8232090490155	HLA-DRB5/HLA-DRA/NFKB1/HLA-DQA1/HLA-DRB1/HLA-DQA2/JAK1/CYCS/STAT3/STAT1/MAP2K3/TGFB1/LAMA2/BIRC2/TAB2/NFKBIA/HLA-DPB1/MAPK8/IFNGR1/LAMB1/HLA-DMA/HLA-DPA1/TRAF6	5.43643517039102
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	18/682	77/9376	3.21377156567772	PIK3R1/NFKB1/BAX/GAB2/SMAD3/CDK6/TGFBR2/MYC/BRAF/TGFB1/NFKBIA/RUNX1/ABL1/SOS2/RAF1/STAT5B/BAK1/SMAD4	5.46296038576442
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	37/682	238/9376	2.13726311639025	PIK3R1/IGF1/GNG2/PLAAT2/REL/NFKB1/CDC42/ARF6/RALGAPA1/PDGFRA/STK4/GAB2/CALM1/PLCG2/PDGFD/ETS1/TIAM1/GNG4/CALM3/GNB1/PAK2/RALA/TGFA/PRKCA/MAPK8/ABL1/SOS2/GNGT2/PAK1/RASA1/FGF10/RAF1/RASGRP3/RASA3/PDGFRB/GNB2/CSF1	4.97727760137581
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	18/682	78/9376	3.17256936611775	HLA-DRB5/ITGB2/HLA-DRA/NFKB1/HLA-DQA1/ITGA4/HLA-DRB1/HLA-DQA2/JAK1/STAT1/TGFB1/TAB2/NFKBIA/HLA-DPB1/IFNGR1/HLA-DMA/HLA-DPA1/TRAF6	5.39627644014893
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	33/682	204/9376	2.22390891840607	CD44/PIK3R1/PPP1CB/IGF1/COL1A1/CTNNB1/CD63/DDX5/FLNA/CDC42/MSN/EZR/HIF1A/HPSE2/PLCG2/DCN/TIAM1/MYC/BRAF/STAT3/TIMP3/TGFB1/FN1/PRKCA/ROCK1/TWIST2/SOS2/PAK1/MMP2/RAF1/WNT5A/RPS6KB1/PPP1CA	4.94994265544193
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	44/682	308/9376	1.96397151235861	PSMA7/TUBA4A/ATP5F1E/NDUFB2/BAX/UQCRB/COX7A2/COX6C/CYCS/NDUFS6/NDUFA13/DCTN6/PSMB1/PSMA6/PSMB6/PSMD8/NDUFA6/ATG2A/PSMA2/PSMD7/MT-ND6/NDUFA4/CREBBP/UQCRQ/PSMB3/NDUFB1/MAPK8/AMBRA1/NDUFB6/TGM2/ATP5F1C/NDUFB8/ATP5MC1/NDUFA12/AP2B1/POLR2K/POLR2J3/NDUFA11/PSMB7/UQCRFS1/POLR2E/COX7B/DCTN5/PSMC4	4.81783375172499
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	52/682	388/9376	1.84248873839828	PIK3R1/PSMA7/CTNNB1/TUBA4A/ATP5F1E/NDUFB2/NFKB1/EIF2AK2/MME/CALM1/UQCRB/COX7A2/COX6C/CYCS/NDUFS6/NDUFA13/EIF2AK3/BRAF/PSMB1/PSMA6/PSMB6/PSMD8/APOE/NDUFA6/ATG2A/CALM3/PSMA2/PSMD7/MT-ND6/NDUFA4/UQCRQ/PSMB3/NDUFB1/MAPK8/AMBRA1/NDUFB6/ATP5F1C/LRP1/NDUFB8/ATP5MC1/NDUFA12/NDUFA11/DKK1/PSMB7/UQCRFS1/CACNA1D/RAF1/COX7B/CSNK2B/WNT5A/PSMC4/CSF1	4.74696951688251
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	18/682	80/9376	3.09325513196481	PIK3R1/IGF1/BAX/PDGFRA/JAK1/PLCG2/PDGFD/BRAF/STAT3/FOXO3/TGFA/PRKCA/EIF4E/SOS2/BCL2L11/RAF1/PDGFRB/RPS6KB1	5.2660758259758
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	46/682	333/9376	1.89909557651493	PIK3R1/ISG15/COL1A1/CTNNB1/MX1/HLA-C/NFKB1/EIF2AK2/BAX/CDC42/FOXO1/HES4/COL6A1/ITGA4/JAK1/CDK6/COL6A3/MX2/BCAP31/STAT1/IRF9/PPP2R2B/UBR4/PPP2CA/PTGER4/HLA-G/LAMA2/COL4A2/FN1/PPP2R2D/PARD6G/CREBBP/ATP6V0E1/OASL/SOS2/LAMB1/COL4A1/ITGB7/RAF1/HES6/PDGFRB/WNT5A/RPS6KB1/BAK1/JAG1/PRKCI	4.67885643829713
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	35/682	227/9376	2.11970493624608	PIK3R1/CXCR4/GNA13/GNG2/CTNNB1/AKAP13/HLA-C/NFKB1/CCL4/BAX/PDGFRA/CALM1/JAK1/CDK6/CYCS/ADCY3/MYC/CALR/STAT3/GNG4/PTGER4/HLA-G/PDIA3/CALM3/GNB1/GNA12/NFKBIA/PRKCA/ROCK1/SOS2/GNGT2/RAF1/RPS6KB1/GNB2/BAK1	4.78297064245301
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	25/682	138/9376	2.49054358451273	ATP5F1E/NDUFB2/UQCRB/COX7A2/COX6C/PPA1/CYCS/NDUFS6/NDUFA13/NDUFA6/MT-ND6/NDUFA4/ATP5ME/UQCRQ/NDUFB1/NDUFB6/ATP5F1C/NDUFB8/ATP5MC1/ATP6V0E1/NDUFA12/COX17/NDUFA11/UQCRFS1/COX7B	4.94041295036143
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	40/682	275/9376	1.99968008531058	PIK3R1/FYN/PSMA7/TUBA4A/ATP5F1E/NDUFB2/BAX/UQCRB/COX7A2/COX6C/CYCS/NDUFS6/NDUFA13/EIF2AK3/PSMB1/RYR2/PSMA6/PSMB6/PSMD8/NDUFA6/PSMA2/PSMD7/MT-ND6/NDUFA4/UQCRQ/PSMB3/NDUFB1/MAPK8/NDUFB6/ATP5F1C/NDUFB8/ATP5MC1/NDUFA12/NDUFA11/PSMB7/UQCRFS1/CACNA1D/COX7B/CSNK2B/PSMC4	4.71249430006556
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	31/682	193/9376	2.20819594912859	PIK3R1/CXCR4/GNG2/CCR9/XCL2/NFKB1/CCL4/CDC42/LYN/XCL1/PLCG2/GRK5/ADCY3/TIAM1/BRAF/STAT3/GNG4/STAT1/FOXO3/GNB1/NFKBIA/PREX1/ROCK1/SOS2/GNGT2/PAK1/CXCR6/RAF1/STAT5B/GNB2/ITK	4.74997960861399
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	34/682	227/9376	2.05914193806762	PIK3R1/NFE2L2/ATP5F1E/NDUFB2/NFKB1/HIF1A/PTPRJ/UQCRB/COX7A2/COX6C/NDUFS6/NDUFA13/BRAF/NDUFA6/FOXO3/PRKD3/MT-ND6/NDUFA4/UQCRQ/NFKBIA/NDUFB1/MAPK8/NDUFB6/ATP5F1C/NDUFB8/ATP5MC1/NDUFA12/NDUFA11/ABL1/SOS2/UQCRFS1/RAF1/COX7B/PTPN1	4.52426762799846
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	13/682	50/9376	3.57442815249267	CXCR4/HLA-DRB5/CCR9/HLA-DRA/HLA-DQA1/ITGA4/HLA-DRB1/HLA-DQA2/TGFB1/HLA-DPB1/HLA-DMA/HLA-DPA1/ITGB7	5.11194391283679
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	18/682	87/9376	2.84437253514005	PIK3R1/CTNNB1/BAX/SMAD3/CYCS/TGFBR2/MYC/BRAF/TGFB1/RALA/TGFA/MAPK8/SOS2/BCL2L11/RAF1/RPS6KB1/BAK1/SMAD4	4.84051754837496
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	27/682	163/9376	2.27724304193728	PIK3R1/YWHAZ/NFKB1/BAX/JAK1/SMAD3/CYCS/TGFBR2/MYC/BRAF/STAT3/STAT1/IFIH1/MAP2K3/TGFB1/TAB2/CREBBP/NFKBIA/PRKCA/MAPK8/EGR2/SOS2/TRAF6/RAF1/STAT5B/IRF7/SMAD4	4.60717617498033
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	31/682	200/9376	2.13090909090909	FYN/WIPF3/MYO5B/GNA13/ARPC3/TUBA4A/CYTH1/MYH9/NFKB1/BAX/CDC42/EZR/ARF6/CYTH3/CYCS/BRK1/F2R/SEC24B/RAB1A/GNA12/TAB2/PAK2/NFKBIA/MAPK8/SEC24A/ROCK1/ABL1/PAK1/TRAF6/NCKAP1L/BAK1	4.52776625277826
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	26/682	157/9376	2.27670582961316	PIK3R1/NDUFB2/NFKB1/BAX/CDC42/UQCRB/COX7A2/COX6C/CYCS/NDUFS6/NDUFA13/EIF2AK3/TGFB1/NDUFA6/ITCH/NDUFA4/UQCRQ/NDUFB1/MAPK8/NDUFB6/NDUFB8/NDUFA12/NDUFA11/UQCRFS1/BCL2L11/COX7B	4.51821369645471
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	41/682	300/9376	1.8788660801564	JUND/DUSP4/IGF1/FLNA/NFKB1/DUSP2/CDC42/PDGFRA/PPM1B/RPS6KA3/STK4/RELB/MAP3K8/PDGFD/TGFBR2/MYC/BRAF/MAP2K3/DUSP5/TGFB1/GNA12/TAB2/PAK2/CACNA2D1/TGFA/PRKCA/MAPK8/SOS2/DUSP16/PAK1/RASA1/FGF10/CACNA1D/RAPGEF2/TRAF6/RAF1/RASGRP3/NFKB2/PDGFRB/CSF1/MAP3K13	4.3331537051212
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	15/682	68/9376	3.03260307055373	PIK3R1/ZBTB16/NFKB1/CSF2/MYC/BRAF/STAT3/RUNX1T1/RUNX1/BCL2A1/SOS2/RAF1/STAT5B/RARA/RPS6KB1	4.71136611356992
Human Diseases	Cancer: specific types	hsa05214	Glioma	16/682	76/9376	2.89427380768637	PIK3R1/IGF1/BAX/PDGFRA/CALM1/CDK6/PLCG2/BRAF/CALM3/TGFA/PRKCA/SOS2/RAF1/PDGFRB/CAMK4/BAK1	4.64382755035669
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	20/682	110/9376	2.49960010663823	BMP8A/SMAD3/DCN/TGFBR2/MYC/ID2/PPP2CA/TGFB1/FBN1/SKP1/ACVR1B/CREBBP/NBL1/ROCK1/TGIF1/TFDP1/RBX1/GDF7/RPS6KB1/SMAD4	4.43091750993956
NA	NA	hsa04518	Integrin signaling	25/682	154/9376	2.23178580949842	PIK3R1/ITGB2/IGF1/COL1A1/CTNNB1/FLNA/CDC42/COL6A1/PDGFRA/ITGA4/ITGAE/PDGFD/COL6A3/TGFB1/LAMA2/FBN1/COL4A2/FN1/PARVB/ACTN4/ACTN1/LAMB1/COL4A1/ITGB7/PDGFRB	4.31669143569659
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	15/682	70/9376	2.94595726853791	FYN/HLA-DRB5/ITGB2/HLA-DRA/HLA-C/HLA-DQA1/HLA-DRB1/HLA-DQA2/CYCS/HLA-G/LAMA2/HLA-DPB1/ABL1/HLA-DMA/HLA-DPA1	4.57687237957945
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	46/682	362/9376	1.74695808557865	PIK3R1/MCL1/IGF1/GNG2/COL1A1/YWHAZ/NFKB1/COL6A1/HSP90B1/PDGFRA/ITGA4/JAK1/CDK6/PDGFD/F2R/COL6A3/MYC/PIK3AP1/GNG4/PPP2R2B/PPP2CA/IL2RB/FOXO3/LAMA2/COL4A2/FN1/GNB1/PPP2R2D/TGFA/PRKCA/EIF4E/IL4R/SOS2/LAMB1/GNGT2/MAGI2/COL4A1/BCL2L11/FGF10/ITGB7/RAF1/PDGFRB/PRLR/RPS6KB1/GNB2/CSF1	4.05938038361729
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	15/682	73/9376	2.82489053147471	EML4/PIK3R1/BAX/STK4/CDK6/PLCG2/BRAF/STAT3/FOXO3/TGFA/PRKCA/SOS2/RAF1/STAT5B/BAK1	4.38384050461981
Human Diseases	Immune disease	hsa05310	Asthma	9/682	32/9376	3.86656891495601	HLA-DRB5/HLA-DRA/HLA-DQA1/HLA-DRB1/HLA-DQA2/FCER1G/HLA-DPB1/HLA-DMA/HLA-DPA1	4.54924125542785
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	17/682	93/9376	2.51303881688897	PIK3R1/NFKB1/BAX/TRAF4/CDK6/CYCS/MYC/LAMA2/COL4A2/FN1/BIRC2/NFKBIA/LAMB1/COL4A1/TRAF6/BAK1/ZBTB17	4.10691180527269
Human Diseases	Immune disease	hsa05330	Allograft rejection	10/682	39/9376	3.52507707346417	HLA-DRB5/HLA-DRA/HLA-C/HLA-DQA1/HLA-DRB1/HLA-DQA2/HLA-G/HLA-DPB1/HLA-DMA/HLA-DPA1	4.42559095101557
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	20/682	122/9376	2.25373780106726	PIK3R1/FYN/CBLB/NFKB1/CDC42/CD247/CSF2/MAP3K8/PTPRC/PPP2R2B/PPP2CA/PPP2R2D/PAK2/PRKCQ/NFKBIA/MAPK8/SOS2/PAK1/RAF1/ITK	3.90382099765896
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	18/682	105/9376	2.35676581483033	PIK3R1/CBLB/NFKB1/CALM1/RELB/PLCG2/FCER1G/STAT1/IRF9/CALM3/NFKBIA/MAPK8/EGR2/PAK1/RAF1/NFKB2/BCL3/CYLD	3.91565354908329
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	22/682	142/9376	2.12994093593821	JUND/FOSL2/PIK3R1/FYN/NFKB1/GAB2/JAK1/RELB/PLCG2/TGFBR2/STAT1/IRF9/TGFB1/TAB2/NFKBIA/MAPK8/IFNGR1/TRAF6/NFKB2/CAMK4/CYLD/CSF1	3.79990717237188
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	17/682	98/9376	2.38482255072117	PIK3R1/BIN1/ARPC3/ASAP1/CDC42/ARF6/LYN/GAB2/CFL1/PLCG2/PTPRC/PLPP3/PRKCA/MARCKS/PAK1/RAF1/RPS6KB1	3.85965057378936
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	21/682	134/9376	2.15450606206504	PRKCH/GNA13/PPP1CB/MYL6/MYH9/CALM1/ADCY3/CALCRL/BRAF/ADORA2A/EDNRA/CALM3/GNA12/PRKCQ/PRKCA/ROCK1/PRKG1/CACNA1D/RAF1/PPP1CA/PPP1R14A	3.76993309055823
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	16/682	90/9376	2.44405343760182	EML4/PIK3R1/NFKB1/HIF1A/CD247/JAK1/STAT3/STAT1/MAP2K3/PRKCQ/NFKBIA/IFNGR1/TRAF6/RAF1/CSNK2B/RPS6KB1	3.8553000804916
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	29/682	212/9376	1.88059536324905	PIK3R1/ITGB2/IGF1/CTNNB1/SIPA1L1/CDC42/PFN1/PDGFRA/CALM1/PDGFD/F2R/ADCY3/TIAM1/BRAF/ADORA2A/MAP2K3/PRKD3/CALM3/PARD6G/RALA/PRKCA/MAGI2/FGF10/RAPGEF2/RAF1/RASGRP3/PDGFRB/CSF1/PRKCI	3.63220031852316
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	33/682	253/9376	1.79319138084916	CD44/PIK3R1/FNBP1/UBC/ARPC3/CYTH1/NFKB1/BAX/CDC42/PFN1/ARF6/FOXO1/CYTH3/CSF2/CYCS/MYL12B/PLCG2/FOXO3/MAP1LC3A/SKP1/TAB2/DIAPH1/PRKCQ/NFKBIA/ACTN4/ACTN1/MAPK8/ROCK1/RBX1/GLMN/TRAF6/ELMO2/RPS6KB1	3.58209761950408
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	15/682	82/9376	2.5148415707031	HLA-DRB5/PSME2/HLA-DRA/HLA-C/PSME1/CD74/HLA-DQA1/HLA-DRB1/HLA-DQA2/CALR/HLA-G/PDIA3/HLA-DPB1/HLA-DMA/HLA-DPA1	3.85869821685581
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	26/682	184/9376	1.94262399591993	PIK3R1/CXCR4/FYN/CDC42/EPHA4/CFL1/MYL12B/PLCG2/SLIT3/SEMA5A/SSH1/PARD6G/PAK2/PRKCA/NRP1/ROCK1/ABL1/TRPC3/PAK1/RASA1/GDF7/RAF1/EPHA6/PLXNC1/WNT5A/TRPC5	3.61668264742444
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	31/682	235/9376	1.81353965183752	ATP5F1E/BMP8A/NDUFB2/RPS6KA3/UQCRB/COX7A2/COX6C/NDUFS6/NDUFA13/ADCY3/MAP2K3/NDUFA6/MT-ND6/NDUFAF8/NDUFA4/ATP5ME/UQCRQ/NDUFB1/NDUFB6/ATP5F1C/NDUFB8/ATP5MC1/NDUFA12/COX17/COX20/NDUFA11/SOS2/UQCRFS1/PRKG1/COX7B/RPS6KB1	3.53739705176741
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	23/682	157/9376	2.01400900311934	ITGB2/PPP1CB/CTNNB1/YWHAZ/BMP8A/SMAD3/TGFBR2/MYC/ID2/PPP2R2B/PPP2CA/TGFB1/SNAI2/BIRC2/PPP2R2D/PARD6G/GDF7/WNT5A/CTNNA3/PPP1CA/CSNK1D/SMAD4/PRKCI	3.58853955230262
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	16/682	93/9376	2.3652130041308	FYN/CTNNB1/CDC42/PTPRJ/SMAD3/MYL12B/TGFBR2/SNAI2/CREBBP/ACTN4/ACTN1/ROCK1/CSNK2B/CTNNA3/PTPN1/SMAD4	3.7056613094071
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	10/682	44/9376	3.12450013329779	HLA-DRB5/HLA-DRA/HLA-C/HLA-DQA1/HLA-DRB1/HLA-DQA2/HLA-G/HLA-DPB1/HLA-DMA/HLA-DPA1	3.95606795877138
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	20/682	130/9376	2.1150462440785	COL3A1/PIK3R1/GNG2/COL1A1/NFKB1/TGFBR2/ADCY3/GNG4/TGFB1/COL4A2/GNB1/NFKBIA/PRKCA/MAPK8/SOS2/GNGT2/COL4A1/MMP2/RAF1/GNB2	3.5855486402971
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	10/682	45/9376	3.05506679700228	HLA-DRB5/HLA-DRA/HLA-C/HLA-DQA1/HLA-DRB1/HLA-DQA2/HLA-G/HLA-DPB1/HLA-DMA/HLA-DPA1	3.87022409433725
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	15/682	86/9376	2.39787219532156	PIK3R1/CBLB/PLCG2/MYC/BRAF/PAK2/TGFA/PRKCA/MAPK8/ABL1/SOS2/PAK1/RAF1/STAT5B/RPS6KB1	3.64734498217962
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	13/682	69/9376	2.59016532789324	PIK3R1/ALOX5AP/FYN/LYN/GAB2/CSF2/PLCG2/FCER1G/MAP2K3/PRKCA/MAPK8/SOS2/RAF1	3.71304297529482
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	25/682	181/9376	1.89886748432462	HLA-DRB5/ITGB2/HLA-DRA/CD74/NFKB1/BAX/HLA-DQA1/HLA-DRB1/HLA-DQA2/CALM1/JAK1/CYCS/FCER1G/STAT1/TGFB1/CTSD/CALM3/CREBBP/HLA-DPB1/MAPK8/IFNGR1/HLA-DMA/HLA-DPA1/TRAF6/RAF1	3.42000781747743
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	13/682	70/9376	2.55316296606619	PIK3R1/CDC42/HIF1A/ETS1/BRAF/TGFB1/CREBBP/PAK2/TGFA/SOS2/PAK1/RBX1/RAF1	3.65302403876272
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	11/682	54/9376	2.80047789725209	HLA-DRB5/HLA-DRA/HLA-C/TG/HLA-DQA1/HLA-DRB1/HLA-DQA2/HLA-G/HLA-DPB1/HLA-DMA/HLA-DPA1	3.71619190130518
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	18/682	116/9376	2.13327940135504	PIK3R1/CXCR4/ITGB2/CTNNB1/CDC42/MSN/EZR/ITGA4/MYL12B/PLCG2/ACTN4/ACTN1/PRKCA/ROCK1/MMP2/RHOH/CTNNA3/ITK	3.43976286728947
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	24/682	174/9376	1.89624835676004	NFE2L2/BAX/HSP90B1/STT3B/EIF2AK3/BCAP31/SEC24B/CALR/SELENOS/SEC61B/SEC61G/MAN1A1/PDIA3/SKP1/VCP/MAPK8/PLAA/SEC24A/RPN2/PDIA6/RAD23B/RBX1/SAR1B/BAK1	3.3421804130859
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	27/682	205/9376	1.81068593090623	PIK3R1/YWHAZ/HLA-C/REL/NFKB1/EIF2AK2/BAX/CDC42/LYN/JAK1/CDK6/STAT3/IRF9/UBR4/HLA-G/HDAC9/CREBBP/NFKBIA/RANBP1/ACTN4/ACTN1/EGR2/STAT5B/KAT2B/NFKB2/IRF7/BAK1	3.28692070793617
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	13/682	73/9376	2.44823846061142	CXCR4/BST2/MX1/APOBEC3G/ELL2/MX2/FEZ1/CREBBP/CPSF6/NELFA/KAT2B/CHMP4A/CHMP4B	3.47902864006095
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	23/682	168/9376	1.88213936601033	PIK3R1/MCL1/IL12RB2/IL21R/PDGFRA/JAK1/CSF2/IL9R/MYC/STAT3/STAT1/IRF9/IL2RB/CREBBP/IFNGR1/IL4R/SOS2/PIAS1/STAM/RAF1/STAT5B/PDGFRB/PRLR	3.23129937285805
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	18/682	120/9376	2.06217008797654	PIK3R1/NFKB1/BAX/CDC42/ARHGDIB/RPS6KA3/CALM1/PLCG2/BRAF/FOXO3/CALM3/NFKBIA/MAPK8/ABL1/SOS2/TRAF6/RAF1/CAMK4	3.27975214399862
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	21/682	149/9376	1.93760947863567	PIK3R1/FYN/GNA13/CYTH1/ARF6/CYTH3/PDGFRA/GAB2/PLCG2/PDGFD/FCER1G/F2R/ADCY3/PLPP3/DGKB/GNA12/RALA/PRKCA/SOS2/RAF1/PDGFRB	3.23111838653758
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	23/682	170/9376	1.85999654993962	ARPC3/MYL6/TUBA4A/MYH9/CDC42/MSN/EZR/RAB8B/MYL12B/TIAM1/PPP2R2B/PPP2CA/PPP2R2D/PARD6G/ACTN4/ACTN1/RUNX1/MAPK8/ROCK1/CACNA1D/RAPGEF2/RAP2C/PRKCI	3.1692295160174
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	20/682	144/9376	1.90941674812643	PIK3R1/PSMA7/ATXN1/CYCS/PSMB1/PUM1/PSMA6/PSMB6/PSMD8/ATG2A/PSMA2/PSMD7/PSMB3/PRKCA/MAPK8/AMBRA1/TRPC3/PSMB7/PUM2/PSMC4	3.08009636211582
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	16/682	106/9376	2.07513971117136	PIK3R1/IGF1/CTNNB1/NFKB1/FOXO1/HSP90B1/PDGFRA/PDGFD/BRAF/CREBBP/NFKBIA/GSTP1/TGFA/SOS2/RAF1/PDGFRB	3.1177836579747
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	21/682	157/9376	1.83887778545679	PIK3R1/PPP1CB/ZFP36L2/HLA-C/NFKB1/FOXO1/CALM1/SMAD3/CDK6/TGFBR2/ETS1/MYC/MAP2K3/TGFB1/HLA-G/FOXO3/CALM3/HIPK1/CACNA1D/RAF1/PPP1CA	2.96875678953457
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	15/682	99/9376	2.08300008886519	PIK3R1/PRKCH/PPP1CB/IGF1/CALM1/PLCG2/ADCY3/MAP2K3/PTGER4/CALM3/PRKCQ/PRKCA/MAPK8/TRPV2/PPP1CA	3.03396327048025
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	15/682	99/9376	2.08300008886519	PIK3R1/GPCPD1/HIF1A/PDGFRA/PDGFD/PLPP3/DGKB/PRKCA/MAPK8/CHPT1/SOS2/SLC22A5/RAF1/PDGFRB/RPS6KB1	3.03396327048025
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	20/682	149/9376	1.8453423606054	GNG2/NDUFB2/NDUFS6/NDUFA13/ADCY3/GNG4/NDUFA6/GNB1/MT-ND6/NDUFA4/PRKCA/NDUFB1/MAPK8/NDUFB6/NDUFB8/NDUFA12/NDUFA11/GNGT2/CACNA1D/GNB2	2.91315447050055
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	15/682	100/9376	2.06217008797654	CD44/HLA-DRB5/HLA-DRA/HLA-DQA1/MME/ITGA4/HLA-DRB1/HLA-DQA2/CSF2/IL9R/HLA-DPB1/IL4R/HLA-DMA/HLA-DPA1/CSF1	2.99076097149654
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	25/682	201/9376	1.70992544608337	ZBTB16/IGF1/REL/DDX5/NFKB1/BAX/FOXO1/CSF2/TGFBR2/MYC/ID2/NFKBIZ/IL2RB/BIRC2/WT1/KDM6A/RUNX1T1/RUNX1/BCL2A1/ITGB7/MEIS1/RARA/BAK1/PBX1/ZBTB17	2.84954646394192
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	28/682	233/9376	1.65209620782098	COL3A1/EMD/ATP1B3/COL1A1/MYH9/COL6A1/CAPZA1/ITGA4/FMNL1/LMNB1/DCN/NID1/SPTBN1/COL6A3/LAMA2/FBN1/COL4A2/FN1/ELN/COL5A2/LBR/LMNA/DIAPH1/FBLN2/FBLN1/COL4A1/ITGB7/SPTBN4	2.82301563117068
Human Diseases	Substance dependence	hsa05032	Morphine addiction	14/682	91/9376	2.1150462440785	PDE4D/PDE4B/GNG2/PDE7A/GRK5/ADCY3/GNG4/GNB1/PRKCA/PDE8A/PDE1C/GNGT2/GNB2/PDE3B	2.99357834723751
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	19/682	140/9376	1.86577293674068	GNA13/GNG2/CALM1/SMAD3/ADCY3/GNG4/RYR2/MAP1LC3A/CALM3/GNB1/SLC8A1/GNGT2/RAF1/CAMK4/RPS6KB1/GNB2/JAG1/SMAD4/PDE3B	2.89064040810398
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	19/682	142/9376	1.83949444467391	CBLB/UBC/UBE2B/UBA6/SKP1/ITCH/BIRC2/UBE2O/UBE2L6/UBE2M/UBE2K/FBXW7/RNF7/RBX1/PIAS1/UBA2/TRAF6/UBE2F/ANAPC11	2.82315726426357
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	27/682	226/9376	1.64243635325565	PIK3R1/PDE4D/ATP1B3/PDE4B/PPP1CB/NFKB1/CALM1/F2R/ADCY3/VIPR2/TIAM1/BRAF/ADORA2A/EDNRA/RYR2/CALM3/ADRB1/CREBBP/NFKBIA/MAPK8/ROCK1/PAK1/CACNA1D/RAF1/CAMK4/PPP1CA/PDE3B	2.73805260844134
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	15/682	103/9376	2.00210688153062	COL3A1/PIK3R1/ITGB2/COL1A1/NFKB1/CSF2/TGFB1/LAMA2/COL4A2/FN1/ACTN4/ACTN1/PRKCA/LAMB1/COL4A1	2.86411554568866
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	18/682	133/9376	1.86060459065552	PIK3R1/IGF1/GABARAPL1/FOXO1/STK4/SMAD3/TGFBR2/BRAF/STAT3/TGFB1/FOXO3/CREBBP/MAPK8/PRMT1/SOS2/BCL2L11/RAF1/SMAD4	2.79956793040177
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	18/682	133/9376	1.86060459065552	PIK3R1/FYN/ITGB2/HLA-C/SH2D1A/CD247/SH2D1B/CSF2/PLCG2/HCST/FCER1G/BRAF/HLA-G/PRKCA/IFNGR1/SOS2/PAK1/RAF1	2.79956793040177
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	9/682	49/9376	2.52510623017535	GALNT11/B4GALT1/OGT/GALNT3/GALNT13/GALNT2/GALNT17/GXYLT2/GXYLT1	2.99774822457054
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	15/682	105/9376	1.96397151235861	TNFAIP3/NFKB1/CCL4/LYN/RELB/PLCG2/BIRC2/TAB2/PRKCQ/NFKBIA/BCL2A1/TRAF6/NFKB2/CSNK2B/CYLD	2.78204125746948
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	15/682	105/9376	1.96397151235861	UBC/GABARAPL1/HIF1A/USP15/EIF2AK3/CCZ1/FOXO3/MAP1LC3A/ATG9A/VCP/MAPK8/AMBRA1/TAX1BP1/CSNK2B/TBC1D15	2.78204125746948
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	17/682	125/9376	1.8697008797654	PIK3R1/FYN/GNA13/NFKB1/BAX/GAB2/FCER1G/PPP2R2B/PPP2CA/CTSD/GNA12/PPP2R2D/PRKCA/MAPK8/ROCK1/S1PR3/RAF1	2.74156522697347
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	10/682	59/9376	2.33013569262886	PIK3R1/CTNNB1/BAX/MYC/BRAF/FOXO3/SOS2/RAF1/CTNNA3/BAK1	2.87046273463945
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	18/682	137/9376	1.80628036903055	PIK3R1/MCL1/TUBA4A/CTSW/NFKB1/BAX/LMNB1/CYCS/EIF2AK3/CTSD/BIRC2/LMNA/NFKBIA/BCL2A1/MAPK8/BCL2L11/RAF1/BAK1	2.6625752673906
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	20/682	158/9376	1.74022792234307	YWHAZ/SMAD3/CDK6/MCM6/MYC/CCNH/PPP2CA/TGFB1/SKP1/CREBBP/STAG2/RAD21/NIPBL/ABL1/TFDP1/RBX1/TFDP2/ANAPC11/ZBTB17/SMAD4	2.6281107482947
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	21/682	169/9376	1.70830658175571	PIK3R1/UBC/GABARAPL1/HIF1A/EIF2AK3/RAB1A/PPP2CA/CTSD/ATG2A/MAP1LC3A/RUBCN/ATG9A/PRKCQ/MTMR3/MAPK8/AMBRA1/TRAF6/RAF1/TAX1BP1/RPS6KB1/RAB39B	2.60239709642391
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	18/682	138/9376	1.79319138084916	PIK3R1/CBLB/PPP1CB/FOXO1/CALM1/PRKAR2A/BRAF/CALM3/MAPK8/EIF4E/SOS2/FASN/RAF1/RPS6KB1/PPP1CA/PTPN1/PDE3B/PRKCI	2.62903615216547
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	21/682	170/9376	1.69825771951009	PIK3R1/NFE2L2/CTNNB1/BAX/SMAD3/CDK6/PLCG2/TGFBR2/MYC/BRAF/TGFB1/GSTP1/TGFA/PRKCA/SOS2/RAF1/BRD7/WNT5A/RPS6KB1/BAK1/SMAD4	2.57319517690361
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	16/682	119/9376	1.84844377633751	PIK3R1/TNFAIP3/TNFRSF1B/NFKB1/CSF2/MAP3K8/MAP2K3/ITCH/BIRC2/TAB2/NFKBIA/MAPK8/BCL3/CYLD/JAG1/CSF1	2.6087317551375
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	15/682	109/9376	1.89189916328123	PIK3R1/PPP1CB/NFKB1/FOXO1/RPS6KA3/OGT/STAT3/PRKCQ/NFKBIA/GFPT1/MAPK8/OGA/RPS6KB1/PPP1CA/PTPN1	2.6231760080562
Human Diseases	Cancer: specific types	hsa05218	Melanoma	11/682	73/9376	2.07158638974812	PIK3R1/IGF1/BAX/PDGFRA/CDK6/PDGFD/BRAF/FGF10/RAF1/PDGFRB/BAK1	2.57421677550209
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	14/682	103/9376	1.86863308942858	PPP1CB/GSPT1/PABPN1/PPP2R2B/PPP2CA/PPP2R2D/RBM8A/ALYREF/CPSF6/RNMT/NXT1/PAPOLG/PPP1CA/MAGOH	2.48263491727748
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	13/682	95/9376	1.88127797499614	HLA-DRB5/ITGB2/HLA-DRA/HLA-DQA1/HLA-DRB1/HLA-DQA2/CSF2/TGFB1/HLA-DPB1/ATP6V0E1/HLA-DMA/HLA-DPA1/CSF1	2.41793899993359
Organismal Systems	Immune system	hsa04611	Platelet activation	16/682	126/9376	1.74575245542987	COL3A1/PIK3R1/FYN/GNA13/PPP1CB/COL1A1/LYN/MYL12B/PLCG2/FCER1G/F2R/ADCY3/ROCK1/PRKG1/PPP1CA/PRKCI	2.36035380166464
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	12/682	86/9376	1.91829775625725	EMD/CTNNB1/ITGA4/RYR2/LAMA2/LMNA/CACNA2D1/SLC8A1/CACNA1D/ITGB7/CTNNA3/GJA1	2.39603357491577
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	10/682	67/9376	2.05191053530004	PPP1CB/RPS6KA3/CALM1/BRAF/CALM3/CREBBP/PRKCA/RAF1/CAMK4/PPP1CA	2.42009658350791
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	6/682	31/9376	2.66086462964715	SPCS2/SEC61B/SRP14/SEC61G/SPCS1/TMEM208	2.59414016531274
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	12/682	87/9376	1.89624835676004	ATP1B3/UQCRB/COX7A2/COX6C/RYR2/UQCRQ/CACNA2D1/SLC8A1/UQCRFS1/SLC9A7/CACNA1D/COX7B	2.35218526406312
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	26/682	238/9376	1.50186056827423	PIK3R1/ISG15/MX1/NFKB1/EIF2AK2/RPS29/JAK1/CSF2/PLCG2/MX2/OAS1/STAT3/STAT1/IFIH1/IRF9/C1R/ADAR/TAB2/CFD/RPS27L/NFKBIA/PRKCA/MAPK8/NRP1/C1S/TRAF6	2.19641288764693
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	6/682	32/9376	2.57771260997067	BAX/CYCS/BIRC2/MAPK8/BCL2L11/BAK1	2.50382792370351
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	12/682	89/9376	1.85363603413622	TUBA4A/PDGFRA/PDGFD/ADCY3/ADRB1/PRKCA/SOS2/PRKG1/RAF1/PDGFRB/CSNK1D/GJA1	2.26619891677075
Organismal Systems	Nervous system	hsa04730	Long-term depression	9/682	60/9376	2.06217008797654	GNA13/IGF1/LYN/BRAF/PPP2CA/GNA12/PRKCA/PRKG1/RAF1	2.31165468589045
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	21/682	187/9376	1.54387065410008	TNFAIP3/GABARAPL1/NAMPT/NFKB1/JAK1/OAS1/STAT1/IRF9/MAP1LC3A/BIRC2/TAB2/TXN/NFKBIA/IFI16/MAPK8/TRAF6/PANX1/TRPV2/CARD16/IRF7/TP53BP1	2.10402216738137
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	10/682	71/9376	1.93630994176201	PIK3R1/NFKB1/STAT3/STAT1/FOXO3/MAPK8/SOS2/RAF1/STAT5B/PRLR	2.21798511874416
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	10/682	72/9376	1.90941674812643	ISG15/NFKB1/RNF125/IFIH1/ADAR/NFKBIA/MAPK8/TRAF6/CYLD/IRF7	2.16951348052467
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	13/682	103/9376	1.73515929732654	PIK3R1/NFKB1/CD247/TGFBR2/CALR/PPP2R2B/PPP2CA/TGFB1/PPP2R2D/NFKBIA/MAPK8/IFNGR1/TRAF6	2.1011542888663
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	11/682	83/9376	1.82199766809172	NFKB1/CCL4/ADAR/GSDME/NFKBIA/IFI16/POLR2K/POLR3E/POLR2E/IRF7/PCBP1	2.10668532843326
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	13/682	105/9376	1.70210864404413	EMD/IGF1/ITGA4/ADCY3/RYR2/TGFB1/LAMA2/ADRB1/LMNA/CACNA2D1/SLC8A1/CACNA1D/ITGB7	2.02629972972694
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	18/682	160/9376	1.5466275659824	HLA-DRB5/ITGB2/HLA-DRA/HLA-C/HLA-DQA1/ITGA4/HLA-DRB1/HLA-DQA2/PTPRC/NLGN1/HLA-G/TIGIT/HLA-DPB1/CD58/HLA-DMA/HLA-DPA1/ITGB7/PTPRD	1.95320710278243
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	16/682	138/9376	1.59394789408815	PIK3R1/WIPF3/ARPC3/NFKB1/CDC42/ARF6/ITGA4/RPS6KA3/MAP2K3/FN1/TAB2/NFKBIA/MAPK8/ROCK1/TRAF6/ELMO2	1.96864278125234
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	6/682	36/9376	2.29130009775171	GALNT11/B4GALT5/GALNT3/GALNT13/GALNT2/GALNT17	2.17406739951224
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	17/682	150/9376	1.55808406647116	PIK3R1/CTNNB1/BAX/SMAD3/TGFBR2/MYC/BRAF/TGFB1/SOS2/FGF10/ABCB1/RAF1/WNT5A/CTNNA3/RPS6KB1/BAK1/SMAD4	1.92977437582587
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	12/682	97/9376	1.70075883544457	GNG2/CALM1/ADCY3/GNG4/RYR2/CALM3/GNB1/PRKCA/GNGT2/PRKG1/CACNA1D/GNB2	1.94299583476475
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	8/682	56/9376	1.96397151235861	ITGB2/NFKB1/CYCS/RAB1A/VCP/NFKBIA/NFKB2/SAR1B	2.02636774824778
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	12/682	98/9376	1.68340415345024	PIK3R1/SACM1L/IP6K1/CALM1/PLCG2/DGKB/CALM3/MTMR3/PRKCA/MTMR6/CDS2/PIK3C2B	1.90472146169241
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	13/682	109/9376	1.6396459415104	PIK3R1/NFKB1/CCL4/JAK1/MAP3K8/STAT1/IRF9/MAP2K3/TAB2/NFKBIA/MAPK8/TRAF6/IRF7	1.88127083923671
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	4/682	20/9376	2.74956011730205	CYP51A1/DHCR7/LBR/SC5D	2.19364713321126
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	12/682	99/9376	1.66640007109215	HLA-DRB5/ITGB2/HLA-DRA/HLA-DQA1/HLA-DRB1/HLA-DQA2/C1R/CFD/HLA-DPB1/C1S/HLA-DMA/HLA-DPA1	1.86688196974903
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	10/682	78/9376	1.76253853673208	ITGB2/NFKB1/CALM1/CFL1/C1R/CALM3/SERPING1/MAPK8/C1S/TRAF6	1.89401029244282
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	13/682	110/9376	1.62474006931485	PIK3R1/IGF1/PFKFB3/NFKB1/HIF1A/PLCG2/STAT3/CREBBP/PRKCA/IFNGR1/EIF4E/RBX1/RPS6KB1	1.84593992760753
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	11/682	89/9376	1.69916636462486	CD44/COL1A1/COL6A1/ITGA4/COL6A3/LAMA2/COL4A2/FN1/LAMB1/COL4A1/ITGB7	1.85611899544365
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	17/682	155/9376	1.50782329013338	HLA-DRB5/ITGB2/TUBA4A/HLA-DRA/HLA-C/HLA-DQA1/HLA-DRB1/HLA-DQA2/CALR/SEC61B/SEC61G/C1R/HLA-G/HLA-DPB1/ATP6V0E1/HLA-DMA/HLA-DPA1	1.78549015784636
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	15/682	133/9376	1.55050382554627	PPP1CB/GNG2/CALM1/GNG4/PPP2R2B/PPP2CA/CALM3/GNB1/PPP2R2D/PRKCA/MAPK8/GNGT2/CACNA1D/PPP1CA/GNB2	1.79080250360844
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	14/682	122/9376	1.57761646074708	PIK3R1/IGF1/PLCG2/ADCY3/STAT3/STAT1/MAP2K3/CREBBP/PRKCA/MAPK8/SOS2/CACNA1D/RAF1/STAT5B	1.79855091402556
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	11/682	91/9376	1.66182204891882	PIK3R1/IFITM1/NFKB1/LYN/PLCG2/PIK3AP1/CD81/NFKBIA/SOS2/RAF1/RASGRP3	1.77680178368304
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	12/682	103/9376	1.6016855052245	COL3A1/ATP1B3/COL1A1/COL6A1/MME/COL6A3/COL4A2/ELN/COL5A2/COL23A1/SLC8A1/COL4A1	1.71967366045511
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	9/682	71/9376	1.74267894758581	NFKB1/CDC42/LYN/PLCG2/GIT1/NFKBIA/MAPK8/ATP6V0E1/PAK1	1.75930082580346
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	16/682	148/9376	1.48624871205516	PIK3R1/IGF1/CTNNB1/BAX/CDK6/MYC/BRAF/SOS2/PGR/FGF10/RAF1/NFKB2/WNT5A/RPS6KB1/BAK1/JAG1	1.66995026244683
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	11/682	93/9376	1.62608394033992	CDC42/CALM1/ADCY3/MAP2K3/CALM3/PRKCA/MAPK8/SOS2/CACNA1D/MMP2/RAF1	1.69940883007918
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	7/682	51/9376	1.88695302167788	KDELR2/PLCG2/ADCY3/SEC61B/SEC61G/PRKCA/ATP6V0E1	1.77880889719592
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/682	14/9376	2.94595726853791	B4GALT1/B3GNT7/CHST2	2.04070865483213
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	11/682	94/9376	1.60878517501716	JUND/TNFAIP3/NFKB1/HSP90B1/TRAF4/CSF2/TAB2/NFKBIA/MAPK8/S100A9/TRAF6	1.66140388019202
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	7/682	52/9376	1.85066546356869	TSPO/APOE/NPC1/LRP1/APOC2/STARD3NL/NPC2	1.72277018909046
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	8/682	63/9376	1.74575245542987	CCNH/RPA1/POLR2K/POLR2J3/RAD23B/RBX1/POLR2E/POLE4	1.66336735113985
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	16/682	154/9376	1.42834291807899	CREM/ATP1B3/PPP1CB/CALM1/ADCY3/RYR2/PPP2R2B/PPP2CA/CALM3/ADRB1/PPP2R2D/CACNA2D1/PRKCA/SLC8A1/CACNA1D/PPP1CA	1.50109230984385
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	17/682	166/9376	1.40790728897997	ATP1B3/GNA13/PPP1CB/CALM1/ADCY3/EDNRA/CALM3/GNA12/ADRB1/ROCK1/SLC8A1/PRKG1/CACNA1D/ADRA2C/RAF1/PPP1CA/PDE3B	1.48509317564552
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	5/682	34/9376	2.02173538036916	POLR2K/POLR2J3/POLR3E/CRCP/POLR2E	1.67157538368034
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	15/682	144/9376	1.43206256109482	PIK3R1/IGF1/CTNNB1/JAK1/SMAD3/KAT6A/MYC/ID2/STAT3/ACVR1B/PCGF5/MEIS1/RAF1/WNT5A/SMAD4	1.46334925695649
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	11/682	99/9376	1.52753339850114	PIK3R1/IGF1/BAX/ADCY3/BRAF/MAPK8/SOS2/MMP2/RAF1/RPS6KB1/JAG1	1.47785486950529
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	11/682	99/9376	1.52753339850114	EMD/IGF1/ITGA4/RYR2/TGFB1/LAMA2/LMNA/CACNA2D1/SLC8A1/CACNA1D/ITGB7	1.47785486950529
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	13/682	122/9376	1.46492957069372	PIK3R1/IGF1/PFKFB3/FOXO1/CAB39/PPP2R2B/PPP2CA/FOXO3/SCD/PPP2R2D/RAB2A/FASN/RPS6KB1	1.44767256675332
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	13/682	122/9376	1.46492957069372	PIK3R1/ATP1B3/CTNNB1/FOXO1/HIF1A/PLCG2/MYC/STAT1/CREBBP/PRKCA/MED30/RAF1/KAT2B	1.44767256675332
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	10/682	89/9376	1.54469669511351	GNG2/GABARAPL1/ADCY3/GNG4/GNB1/PLCL1/PRKCA/GNGT2/CACNA1D/GNB2	1.44603907411654
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	9/682	78/9376	1.58628468305888	BTG1/CNOT6L/TENT4B/DDX6/LSM7/DHX36/BTG3/LSM3/CNOT6	1.45622702397955
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	10/682	90/9376	1.52753339850114	PIK3R1/IGF1/NFKB1/BAX/FOXO1/ADCY3/FOXO3/EIF4E/CAMK4/RPS6KB1	1.40839632436389
Organismal Systems	Endocrine system	hsa04924	Renin secretion	8/682	69/9376	1.59394789408815	CALM1/EDNRA/PTGER4/CALM3/ADRB1/PDE1C/CACNA1D/PDE3B	1.38687092288508
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	5/682	37/9376	1.85781089006895	CTNNB1/BAX/MYC/BRAF/BAK1	1.46423315787396
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	14/682	138/9376	1.39470440732713	PPP1CB/IGF1/YWHAZ/RPS6KA3/CALM1/ADCY3/PPP2CA/CALM3/SKP1/PGR/RBX1/PPP1CA/ANAPC11/STAG3	1.30824941033921
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	12/682	115/9376	1.43455310467933	JUND/PDE4D/PDE4B/GNA13/AKAP13/ADCY3/BRAF/GNA12/GATA3/BGLAP/PRKCA/RAF1	1.31319990542135
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	17/682	178/9376	1.31299219084649	CTNNB1/TBL1X/APCDD1/SMAD3/MYC/SKP1/SFRP4/CREBBP/PRKCA/MAPK8/PRICKLE1/DKK1/RBX1/CSNK2B/WNT5A/TLE3/SMAD4	1.18076863444034
Organismal Systems	Sensory system	hsa04744	Phototransduction	4/682	29/9376	1.89624835676004	CALM1/CALM3/GNB1/SLC24A1	1.35381480028909
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	14/682	143/9376	1.34593851895905	HLA-DRB5/HLA-DRA/HLA-DQA1/HLA-DRB1/HLA-DQA2/C1R/HLA-DPB1/ACTN4/ACTN1/SSB/SNRPB/C1S/HLA-DMA/HLA-DPA1	1.16751785315688
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	11/682	108/9376	1.40023894862605	KPNA2/NUP98/SUMO2/KPNA6/KPNA1/RBM8A/ALYREF/NUP58/SUMO1/NXT1/MAGOH	1.17167245951079
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	20/682	217/9376	1.26707839507007	PIK3R1/NFKB1/HSP90B1/KPNA2/RPS6KA3/ADCY3/MYC/STAT3/KPNA6/ADRB1/KPNA1/PRKCA/SOS2/PGR/FGF10/CACNA1D/RAF1/STAT5B/RPS6KB1/JAG1	1.11484015451061
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	9/682	88/9376	1.406025059984	ITGB2/F2R/A2M/C1R/CFD/SERPING1/F2RL2/C1S/TFPI	1.07176872410145
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	3/682	21/9376	1.96397151235861	CHST12/CHST7/XYLT1	1.2385682950314
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	4/682	32/9376	1.71847507331378	GABARAPL1/PPP2CA/ATG2A/ATG9A	1.14021903588729
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	5/682	44/9376	1.56225006664889	B4GALT1/STT3B/MAN1A1/ALG13/RPN2	1.04697544548235
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	5/682	44/9376	1.56225006664889	ARHGDIB/ADCY3/DCTN6/RAB11A/DCTN5	1.04697544548235
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	11/682	115/9376	1.31500701262272	PIK3R1/FYN/GNG2/ADCY3/GNG4/GNB1/PRKCA/GNGT2/CACNA1D/CAMK4/GNB2	0.95193700086086
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	12/682	128/9376	1.28885630498534	PDE4D/PDE4B/PDE7A/PDE9A/ADCY3/GUK1/PDE8A/PDE1C/APRT/NME2/NME1/PDE3B	0.921575527241946
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	22/682	254/9376	1.19075438150876	CXCR4/PDGFRA/CALM1/PLCG2/PDGFD/F2R/ADCY3/ADORA2A/EDNRA/RYR2/MCOLN2/CALM3/ADRB1/TGFA/PRKCA/PDE1C/SLC8A1/FGF10/CACNA1D/P2RX5/PDGFRB/CAMK4	0.863205808750203
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	19/682	216/9376	1.2092972738134	PIK3R1/NFE2L2/NFKB1/BAX/CDC42/HSP90B1/LYN/CALM1/CYCS/EIF2AK3/STAT3/MAP2K3/CALM3/TAB2/NFKBIA/PRKCA/MAPK8/TRAF6/IRF7	0.871586947550298
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	4/682	34/9376	1.61738830429532	SKP1/RORB/RBX1/CSNK1D	1.01005711602093
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3/682	23/9376	1.79319138084916	ATP1B3/SLC4A4/GLUD1	1.06668071846989
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	13/682	142/9376	1.25860146214531	PIK3R1/NFE2L2/CTNNB1/NFKB1/HSP90B1/CALM1/SUMO2/CALM3/TXN/GSTP1/MAPK8/MMP2/SUMO1	0.869657448046947
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	7/682	69/9376	1.39470440732713	PPP1CB/CALM1/CALM3/PRKCA/CACNA1D/CAMK4/PPP1CA	0.921636512403128
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	15/682	168/9376	1.22748219522413	TNFAIP3/EIF2AK2/BAX/JAK1/STAT3/STAT1/IRF9/BIRC2/MAPK8/IFNGR1/STAT5B/CHMP4A/CYLD/GLUD1/CHMP4B	0.83327318005157
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	14/682	157/9376	1.22591852363786	DUSP4/ATP11B/DUSP2/HIF1A/CALR/DUSP5/TGFB1/PTGER4/LRP1/DNMT3A/DUSP16/UQCRFS1/PANX1/PBX1	0.799517119846376
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	25/682	298/9376	1.15333897537838	CXCR4/TNFRSF1B/IL12RB2/CCR9/IL21R/BMP8A/XCL2/CCL4/RELL1/XCL1/CSF2/TGFBR2/IL9R/TGFB1/IL2RB/TNFRSF18/ACVR1B/RELT/IFNGR1/IL4R/CXCR6/GDF7/TNFRSF4/PRLR/CSF1	0.753413863544352
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	8/682	83/9376	1.32508921315762	OGT/KDM2B/FOXK2/SKP1/CREBBP/TFDP1/PCGF5/CSNK2B	0.833166202747236
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	7/682	71/9376	1.35541695923341	PIK3R1/HIF1A/PDGFRA/MYC/RAF1/PDGFRB/TIGAR	0.841932239922072
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	6/682	59/9376	1.39808141557731	PIK3R1/PLAAT2/ADCY3/ADRB1/PRKG1/PDE3B	0.859068646228742
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	6/682	60/9376	1.37478005865103	PIK3R1/CDC42/PLCG2/SH2D2A/PRKCA/RAF1	0.815652868185533
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	10/682	110/9376	1.24980005331911	PIK3R1/IGF1/RPS6KA3/ADCY3/BRAF/MAPK8/PGR/RAF1/ANAPC11/PDE3B	0.738092392322377
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	6/682	62/9376	1.33043231482357	PIK3R1/IGF1/FOXO1/ADCY3/FOXO3/RPS6KB1	0.731102465301934
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	6/682	62/9376	1.33043231482357	ATXN1/ITCH/CREBBP/KAT2B/TLE3/JAG1	0.731102465301934
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	5/682	50/9376	1.37478005865103	ITGB2/GYPC/CD81/TGFB1/LRP1	0.744186485693422
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	4/682	38/9376	1.44713690384319	PIK3R1/ATP1B3/IGF1/PRKCA	0.773523275702206
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	7/682	75/9376	1.28312805474096	PIK3R1/BAX/CYCS/BIRC2/GSTP1/BAK1/REV3L	0.689472140302735
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	12/682	139/9376	1.18686048228866	PIK3R1/HSP90B1/CALM1/ADCY3/CTSD/CALM3/TGFA/SOS2/PGR/MMP2/RAF1/RARA	0.621623467185487
Human Diseases	Substance dependence	hsa05034	Alcoholism	16/682	191/9376	1.15164821667102	PPP1CB/GNG2/CALM1/BRAF/ADORA2A/GNG4/CALM3/GNB1/HDAC9/SOS2/GNGT2/RAF1/PKIA/CAMK4/PPP1CA/GNB2	0.593037857929763
NA	NA	hsa04081	Hormone signaling	18/682	219/9376	1.12995621258988	PIK3R1/GNA13/IGF1/GNG2/ADCY3/VIPR2/STAT3/GNG4/GNB1/GNA12/ADRB1/GNGT2/PRKG1/ADRA2C/STAT5B/PRLR/GNB2/SMAD4	0.545017570943196
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	13/682	154/9376	1.16052862093918	PPP1CB/MYL6/CALM1/ADCY3/RYR2/CALM3/CACNA2D1/PRKCA/ROCK1/CACNA1D/RAF1/CAMK4/PPP1CA	0.562559267892933
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	7/682	78/9376	1.23377697571246	PIK3R1/ARPC3/CTNNB1/CDC42/FN1/ELMO2/CTNNA3	0.580660487053024
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	5/682	53/9376	1.2969623194821	ATP1B3/RAB11A/PRKCA/AP2B1/SLC8A1	0.607196762075948
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	4/682	41/9376	1.34124883770832	MYC/BRAF/MMP2/RAF1	0.613301399435297
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	12/682	144/9376	1.14565004887586	CTNNB1/TRA2A/NFKB1/FOXO1/MAP2K3/FOXO3/SCD/TAB2/NFKBIA/MAPK8/FASN/TRAF6	0.4933009938609
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	13/682	158/9376	1.131148149523	PIK3R1/IGF1/RPS6KA3/PRR5L/CAB39/BRAF/PRKCA/EIF4E/SOS2/LAMTOR5/RAF1/WNT5A/RPS6KB1	0.465629370328728
Organismal Systems	Digestive system	hsa04970	Salivary secretion	8/682	93/9376	1.1826065020654	ATP1B3/CALM1/ADCY3/CALM3/ADRB1/PRKCA/LYZ/PRKG1	0.495657342482424
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	5/682	56/9376	1.22748219522413	B4GALT1/STT3B/MAN1A1/ALG13/RPN2	0.478191085310103
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	6/682	70/9376	1.17838290741517	TNFRSF1B/NFKB1/STAT3/PRKCQ/NFKBIA/MAPK8	0.419554845904183
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	25/682	323/9376	1.06407125282587	CD44/PIK3R1/ZEB2/MCL1/NFKB1/EZR/PDGFRA/CDK6/PLCG2/MYC/STAT3/TIMP3/CREBBP/PRKCA/ZFPM2/ROCK1/DNMT3A/ABL1/SOS2/MARCKS/BCL2L11/ABCB1/RAF1/PDGFRB/BAK1	0.3281982225593
Genetic Information Processing	Transcription	hsa03040	Spliceosome	19/682	243/9376	1.07493091005636	SRSF2/TRA2A/DDX5/HNRNPA3/SRSF7/LSM7/SRSF10/HNRNPM/SRSF5/SF1/RBM8A/SNRPB/ALYREF/SF3B5/PCBP1/MAGOH/WBP11/LSM3/SNRPA1	0.331455647268902
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/682	19/9376	1.44713690384319	HPSE2/HGSNAT	0.546407948842898
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	8/682	98/9376	1.12226943563349	ATP1B3/CALM1/ADCY3/PRKD3/CALM3/PRKCA/CACNA1D/CAMK4	0.340778172014852
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	8/682	100/9376	1.09982404692082	CXCR4/TNFRSF1B/CCR9/XCL2/CCL4/XCL1/IL2RB/CSF1	0.281075382301884
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	8/682	101/9376	1.0889346999216	CTNNB1/CALM1/ADCY3/CALM3/CREBBP/PRKCA/RAF1/WNT5A	0.251676681779544
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	19/682	250/9376	1.04483284457478	LITAF/CTSW/CD63/LAPTM4A/AP1S1/HGSNAT/MCOLN2/CTSD/CLN8/NPC1/ATP6V0E1/AP2B1/GGA2/LAMP3/OSBPL7/LAMTOR5/SCARB2/ARL8A/NPC2	0.201230624400038
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	9/682	115/9376	1.0759148285095	GNG2/BRAF/GNG4/GNB1/PRKCA/GNGT2/CACNA1D/RAF1/GNB2	0.229411191739884
NA	NA	hsa03272	Virion - Hepatitis viruses	4/682	48/9376	1.14565004887586	CD63/CD81/CHMP4A/CHMP4B	0.283338109774398
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	6/682	75/9376	1.09982404692082	IGF1/BAX/CDK6/CYCS/SHISA5/EI24	0.243091061206033
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	6/682	76/9376	1.08535267788239	ATP1B3/EZR/CALM1/ADCY3/CALM3/PRKCA	0.209242779707264
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	8/682	104/9376	1.05752312203925	PLAAT2/GPCPD1/PLPP3/DGKB/CHPT1/CDS2/SELENOI/ETNK1	0.165211553490245
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	3/682	36/9376	1.14565004887586	MCM6/RPA1/POLE4	0.245220319854143
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	6/682	78/9376	1.05752312203925	SACM1L/IP6K1/PLCG2/MTMR3/MTMR6/PIK3C2B	0.14287721858976
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	2/682	23/9376	1.19546092056611	MVD/IDI1	0.262855094263678
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/682	23/9376	1.19546092056611	MME/ATP6AP2	0.262855094263678
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	4/682	51/9376	1.07825886953022	PLAAT2/PLPP3/CHPT1/SELENOI	0.156950334462473
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	5/682	65/9376	1.05752312203925	PIK3R1/PRKCA/CACNA1D/RAF1/TRPC5	0.130337375508199
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/682	24/9376	1.14565004887586	EXT1/XYLT1	0.20009305455969
NA	NA	hsa04519	Cadherin signaling	29/682	404/9376	0.986847071803954	KRT86/PPP1CB/KRT81/ARPC3/CTNNB1/YWHAZ/NFKB1/CDC42/PDGFRA/LHFPL3/BRK1/MAP2K3/CDH11/CREBBP/NFKBIA/ACTN4/ACTN1/MAPK8/ROCK1/PRICKLE1/LHFPL6/PCDH18/RAF1/PDGFRB/NCKAP1L/WNT5A/CTNNA3/PPP1CA/GJA1	-0.0756896517319248
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	4/682	54/9376	1.01835559900076	RPA1/FANCA/WDR48/REV3L	0.0378860126271688
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	6/682	85/9376	0.970432982577195	CTPS1/GUK1/NT5C3A/APRT/NME2/NME1	-0.0766926523327408
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	2/682	27/9376	1.01835559900076	SCD/FADS1	0.0267507443691921
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/682	12/9376	1.14565004887586	NPC1	0.141396468532263
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	3/682	42/9376	0.981985756179305	PCBP2/MAP1LC3A/PCBP1	-0.0327698754768458
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	8/682	116/9376	0.948124178380018	GNG2/ADCY3/GNG4/GNB1/PRKCA/GNGT2/CACNA1D/GNB2	-0.157455014804988
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/682	28/9376	0.981985756179305	B3GNT5/B4GALT1	-0.0267364478934776
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/682	13/9376	1.05752312203925	XRCC6	0.0581265599399236
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	4/682	59/9376	0.932054277051543	CTPS1/NT5C3A/NME2/NME1	-0.146628397976613
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	5/682	75/9376	0.916520039100684	ATP1B3/TG/HSP90B1/ADCY3/PRKCA	-0.20329001789067
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	7/682	107/9376	0.899388823416559	FOXO1/CALM1/CALM3/CREBBP/PRMT1/SIK1/PDE3B	-0.293149854651291
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	3/682	47/9376	0.877519186372995	PIK3R1/MAPK8/CACNA1D	-0.235758550499354
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/682	15/9376	0.916520039100684	ST3GAL5	-0.0906222313653575
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	4/682	63/9376	0.872876227714937	PHYKPL/KMT2E/SETD2/DLST	-0.283543863426935
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	4/682	63/9376	0.872876227714937	CTNNB1/BAX/WNT5A/BAK1	-0.283543863426935
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	3/682	48/9376	0.859237536656892	PIK3R1/ATP1B3/CACNA1D	-0.273830119513513
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	4/682	65/9376	0.846018497631401	ADCY3/PDE8A/CACNA1D/PBX1	-0.348895264791751
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/682	17/9376	0.808694152147662	GLUD1	-0.221108781082492
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/682	17/9376	0.808694152147662	MYH9	-0.221108781082492
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/682	35/9376	0.785588604943444	PFKFB3/TIGAR	-0.355920666726397
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/682	18/9376	0.76376669925057	FASN	-0.280966057723611
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/682	18/9376	0.76376669925057	LMBRD1	-0.280966057723611
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	5/682	86/9376	0.799290731773853	ATP1B3/ADCY3/RYR2/PRKCA/CACNA1D	-0.523693042033206
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	6/682	102/9376	0.808694152147662	ATP1B3/ADCY3/RAB11A/RYR2/PRKCA/SLC4A4	-0.544080039640848
Cellular Processes	Cell motility	hsa04814	Motor proteins	12/682	194/9376	0.850379417722284	MYO5B/MYL6/TUBA4A/MYH9/BICDL1/CAPZA1/MYL12B/DCTN6/DYNLT1/KIF26B/DCTN5/MYO9B	-0.589782074752127
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/682	37/9376	0.743124356027582	GFPT1/GLUD1	-0.438471742092719
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/682	19/9376	0.723568451921593	DLST	-0.337803464403739
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	3/682	57/9376	0.723568451921593	SCD/FADS1/FASN	-0.586284463381232
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	2/682	41/9376	0.670624418854159	RPA1/RBBP8	-0.591962470006192
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	4/682	76/9376	0.723568451921593	UBC/DBI/FABP5/SCD	-0.677674174422621
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/682	23/9376	0.597730460283055	GLUD1	-0.540970529942533
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/682	23/9376	0.597730460283055	B4GALT1	-0.540970529942533
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/682	23/9376	0.597730460283055	RPA1	-0.540970529942533
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	2/682	44/9376	0.624900026659557	CCNH/GTF2F2	-0.69848006249107
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	2/682	44/9376	0.624900026659557	MPG/POLE4	-0.69848006249107
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/682	26/9376	0.528761561019626	PLAAT2	-0.67389088912061
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/682	26/9376	0.528761561019626	NR5A2	-0.67389088912061
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/682	26/9376	0.528761561019626	LMBRD1	-0.67389088912061
NA	NA	hsa04082	Neuroactive ligand signaling	11/682	199/9376	0.759928675636246	GNG2/ADCY3/ADORA2A/GNG4/GNB1/ADRB1/PRKCA/GNGT2/ADRA2C/P2RX5/GNB2	-0.958703842934366
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/682	27/9376	0.50917779950038	OXCT2	-0.715305407126502
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/682	28/9376	0.490992878089652	ATP6V0E1	-0.755460097455243
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	8/682	155/9376	0.709563901239239	CTNNB1/CDK6/ADCY3/BRAF/PDE8A/CACNA1D/WNT5A/PBX1	-1.02116386919636
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/682	29/9376	0.474062089190009	PAK1	-0.794447791526972
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/682	30/9376	0.458260019550342	DLST	-0.832351246683884
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/682	30/9376	0.458260019550342	PGAP1	-0.832351246683884
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/682	30/9376	0.458260019550342	PLAAT2	-0.832351246683884
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/682	30/9376	0.458260019550342	NFKB1	-0.832351246683884
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	2/682	52/9376	0.528761561019626	IGF1/ADCY3	-0.954353467252712
Organismal Systems	Digestive system	hsa04976	Bile secretion	4/682	90/9376	0.611013359400456	ATP1B3/ADCY3/ABCB1/SLC4A4	-1.03850743176381
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/682	32/9376	0.429618768328446	B4GALT1	-0.90519429583705
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	2/682	54/9376	0.50917779950038	DNMT3A/MAT2B	-1.01305852699512
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/682	55/9376	0.499920021327646	B4GALT5/PLPP3	-1.04173574356634
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/682	33/9376	0.416600017773038	DLST	-0.940260549214759
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/682	33/9376	0.416600017773038	STX11	-0.940260549214759
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	2/682	56/9376	0.490992878089652	SPOPL/CSNK1D	-1.06998557762758
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	3/682	79/9376	0.522068376702921	ATP6V0E1/AP2B1/SYT1	-1.19474688036549
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/682	36/9376	0.381883349625285	GYG1	-1.04067773325125
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	2/682	59/9376	0.466027138525772	GSTP1/PRDX6	-1.15232544218197
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/682	37/9376	0.371562178013791	GFPT1	-1.07270670874828
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/682	37/9376	0.371562178013791	PRKCA	-1.07270670874828
Organismal Systems	Digestive system	hsa04978	Mineral absorption	2/682	61/9376	0.450747560213451	ATP1B3/SLC8A1	-1.20535088260726
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/682	38/9376	0.361784225960796	GFPT1	-1.10407964964744
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/682	38/9376	0.361784225960796	NAMPT	-1.10407964964744
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/682	38/9376	0.361784225960796	PTPRC	-1.10407964964744
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	3/682	82/9376	0.502968314140619	GSTP1/NME2/NME1	-1.26606987624208
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/682	39/9376	0.352507707346417	MAT2B	-1.13483111518999
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	2/682	63/9376	0.436438113857469	PLAAT2/PTGDS	-1.25699947071033
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	2/682	65/9376	0.4230092488157	PLPP3/DGKB	-1.30736054539165
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/682	42/9376	0.327328585393102	DLST	-1.22366271451136
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/682	43/9376	0.319716292709541	PLPP3	-1.2522229882019
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/682	68/9376	0.404347076073831	ALDH1A3/ALDH1A1	-1.38066258085012
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/682	45/9376	0.305506679700228	ABCB1	-1.30791115184246
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/682	48/9376	0.286412512218964	OXCT2	-1.38816657808934
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	4/682	117/9376	0.470010276461889	BAZ1A/GATAD2B/BRD7/CDK2AP2	-1.61564650387304
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/682	49/9376	0.280567358908373	NFKB1	-1.41411652503875
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	18/682	370/9376	0.668811920424824	NR3C1/GPR35/GZMA/PGRMC2/F2R/P2RY8/VIPR2/CALCRL/ADORA2A/EDNRA/TSPO/PTGER4/ADRB1/F2RL2/S1PR3/ADRA2C/P2RX5/PRLR	-1.8204451374779
NA	NA	hsa04382	Cornified envelope formation	9/682	217/9376	0.570185277781532	KRT86/KRT81/S100A6/PPP2R2B/PPP2CA/COL4A2/PPP2R2D/COL4A1/S100A9	-1.79413505612558
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	7/682	195/9376	0.493510790284984	PIK3R1/ITGB2/NFKB1/PLCG2/HDAC9/PRKCA/RAF1	-2.00175313406814
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/682	70/9376	0.196397151235861	GSTP1	-1.89006600613763
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/682	73/9376	0.188326035431647	GSTP1	-1.94984254729221
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/682	75/9376	0.183304007820137	MAT2B	-1.98881433427748
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	4/682	154/9376	0.357085729519747	CTPS1/NME2/MAT2B/NME1	-2.25303985795981
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/682	79/9376	0.174022792234307	GSTP1	-2.06480099689417
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	5/682	183/9376	0.375622966844543	PWP2/NXT1/CSNK2B/TCOF1/WDR43	-2.38897630465914
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	1/682	83/9376	0.165636151644702	PRDX5	-2.13837842385349
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	2/682	116/9376	0.237031044595005	DLST/GLUD1	-2.31578574406166
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/682	86/9376	0.15985814635477	PDE1C	-2.19210825171834
Genetic Information Processing	Translation	hsa03010	Ribosome	5/682	222/9376	0.309635148344826	RPS29/RPS27L/MRPL47/MRPL23/MRPL33	-2.91553133185146
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	7/682	449/9376	0.214330966827554	CALM1/ADCY3/CALM3/GNB1/PDE1C/SLC8A1/PRKG1	-4.7783509824327