ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0044389 ubiquitin-like protein ligase binding 46/1183 322/18639 0.142857142857143 2.25081511894699 1.98892322190874e-07 0.000183407607295073 GO:0023026 MHC class II protein complex binding 11/1183 27/18639 0.407407407407407 6.41899126514511 3.25768396616471e-07 0.000183407607295073 GO:0140297 DNA-binding transcription factor binding 60/1183 488/18639 0.122950819672131 1.9371769466347 6.46908476761482e-07 0.000207524345900624 GO:0003725 double-stranded RNA binding 18/1183 75/18639 0.24 3.78136939983094 7.37209044051951e-07 0.000207524345900624 GO:0003712 transcription coregulator activity 60/1183 495/18639 0.121212121212121 1.90978252516714 1.04234274583835e-06 0.000234735586362797 GO:0031625 ubiquitin protein ligase binding 42/1183 302/18639 0.139072847682119 2.19119087738548 1.37311227702779e-06 0.000238690575149301 GO:0046332 SMAD binding 18/1183 79/18639 0.227848101265823 3.58990765806735 1.66621467411087e-06 0.000238690575149301 GO:0023023 MHC protein complex binding 12/1183 37/18639 0.324324324324324 5.10995864842019 1.69584778081208e-06 0.000238690575149301 GO:0001221 transcription coregulator binding 22/1183 115/18639 0.191304347826087 3.01413502885075 2.85185036609777e-06 0.000356798168025121 GO:0140313 molecular sequestering activity 14/1183 55/18639 0.254545454545455 4.010543302851 5.94379220712006e-06 0.000669271002521718 GO:0042277 peptide binding 35/1183 249/18639 0.140562248995984 2.21465744635346 8.03227661147773e-06 0.000822213042229448 GO:0045296 cadherin binding 42/1183 334/18639 0.125748502994012 1.98125642206711 1.76641080373231e-05 0.00165748213750216 GO:0048407 platelet-derived growth factor binding 6/1183 11/18639 0.545454545454545 8.59402136325213 2.26080582806581e-05 0.00195820566338623 GO:0032182 ubiquitin-like protein binding 20/1183 120/18639 0.166666666666667 2.62595097210482 6.42723238557187e-05 0.00516933119010995 GO:0001223 transcription coactivator binding 11/1183 44/18639 0.25 3.93892645815723 7.05481095768649e-05 0.00529581142556999 GO:0050699 WW domain binding 8/1183 24/18639 0.333333333333333 5.25190194420964 7.56456058014757e-05 0.00532355950827885 GO:0042578 phosphoric ester hydrolase activity 42/1183 363/18639 0.115702479338843 1.82297422856863 0.000122130144249752 0.00808932602501301 GO:0043130 ubiquitin binding 17/1183 100/18639 0.17 2.67846999154691 0.000173408924261344 0.010408818232366 GO:0019902 phosphatase binding 26/1183 190/18639 0.136842105263158 2.15604395604396 0.00017563725258877 0.010408818232366 GO:0032395 MHC class II receptor activity 5/1183 10/18639 0.5 7.87785291631445 0.000196619060207676 0.0109610818238854 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 40/1183 349/18639 0.114613180515759 1.8058115567483 0.000214002593220576 0.0109610818238854 GO:0005178 integrin binding 23/1183 161/18639 0.142857142857143 2.25081511894699 0.000215057145189675 0.0109610818238854 GO:0051020 GTPase binding 37/1183 315/18639 0.117460317460317 1.85067020891197 0.000223894211322703 0.0109610818238854 GO:0008081 phosphoric diester hydrolase activity 15/1183 87/18639 0.172413793103448 2.71650100562567 0.000350240419278839 0.0164321130044989 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 7/1183 23/18639 0.304347826086957 4.79521481862619 0.000405696394890449 0.0176233281279212 GO:0019208 phosphatase regulator activity 18/1183 117/18639 0.153846153846154 2.42395474348137 0.000407919426055579 0.0176233281279212 GO:0042605 peptide antigen binding 10/1183 45/18639 0.222222222222222 3.50126796280642 0.000422584244630437 0.0176233281279212 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 7/1183 24/18639 0.291666666666667 4.59541420118343 0.00054159966098591 0.0210290075265564 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 7/1183 24/18639 0.291666666666667 4.59541420118343 0.00054159966098591 0.0210290075265564 GO:0019903 protein phosphatase binding 20/1183 144/18639 0.138888888888889 2.18829247675402 0.000777921187957582 0.0268125133464517 GO:0019955 cytokine binding 20/1183 144/18639 0.138888888888889 2.18829247675402 0.000777921187957582 0.0268125133464517 GO:0019956 chemokine binding 8/1183 33/18639 0.242424242424242 3.81956505033428 0.000856651027687805 0.0268125133464517 GO:0140311 protein sequestering activity 8/1183 33/18639 0.242424242424242 3.81956505033428 0.000856651027687805 0.0268125133464517 GO:0001222 transcription corepressor binding 10/1183 49/18639 0.204081632653061 3.21545016992427 0.000864069965844522 0.0268125133464517 GO:0003713 transcription coactivator activity 30/1183 256/18639 0.1171875 1.8463717772612 0.000875945798452612 0.0268125133464517 GO:0140375 immune receptor activity 21/1183 156/18639 0.134615384615385 2.1209604005462 0.000880725382579947 0.0268125133464517 GO:0008137 NADH dehydrogenase (ubiquinone) activity 9/1183 41/18639 0.219512195121951 3.4585695730161 0.000894800130989206 0.0268125133464517 GO:0004112 cyclic-nucleotide phosphodiesterase activity 7/1183 26/18639 0.269230769230769 4.2419208010924 0.000920608900280178 0.0268125133464517 GO:0050840 extracellular matrix binding 12/1183 67/18639 0.17910447761194 2.8219174625604 0.000939313726747023 0.0268125133464517 GO:0044325 transmembrane transporter binding 19/1183 136/18639 0.139705882352941 2.2011647854408 0.000968615423288837 0.0268125133464517 GO:0005201 extracellular matrix structural constituent 22/1183 168/18639 0.130952380952381 2.06324719236807 0.000976299331442736 0.0268125133464517 GO:0030695 GTPase regulator activity 49/1183 489/18639 0.100204498977505 1.57879260899553 0.00104022162731944 0.0278115444897038 GO:0045309 protein phosphorylated amino acid binding 11/1183 59/18639 0.186440677966102 2.9375044772698 0.00107399184302021 0.0278115444897038 GO:0060589 nucleoside-triphosphatase regulator activity 49/1183 490/18639 0.1 1.57557058326289 0.00108677438503283 0.0278115444897038 GO:0019888 protein phosphatase regulator activity 16/1183 107/18639 0.149532710280374 2.35599339553329 0.00114401614363354 0.028625826171808 GO:0031490 chromatin DNA binding 18/1183 128/18639 0.140625 2.21564613271344 0.0012057617947996 0.0295149517596599 GO:0005161 platelet-derived growth factor receptor binding 5/1183 14/18639 0.357142857142857 5.62703779736747 0.00126088180936785 0.0302075088797489 GO:0097110 scaffold protein binding 12/1183 70/18639 0.171428571428571 2.70097814273638 0.001398722712658 0.0328117036344355 GO:0046875 ephrin receptor binding 7/1183 28/18639 0.25 3.93892645815723 0.00148239983971244 0.0331720091659971 GO:0051019 mitogen-activated protein kinase binding 7/1183 28/18639 0.25 3.93892645815723 0.00148239983971244 0.0331720091659971 GO:0003954 NADH dehydrogenase activity 9/1183 44/18639 0.204545454545455 3.22275801121955 0.0015256784439914 0.0331720091659971 GO:0009931 calcium-dependent protein serine/threonine kinase activity 6/1183 21/18639 0.285714285714286 4.50163023789397 0.00153192227054338 0.0331720091659971 GO:0051015 actin filament binding 25/1183 209/18639 0.119617224880383 1.88465380773073 0.00170452730062722 0.034898292095274 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 5/1183 15/18639 0.333333333333333 5.25190194420964 0.00179313418439879 0.034898292095274 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 5/1183 15/18639 0.333333333333333 5.25190194420964 0.00179313418439879 0.034898292095274 GO:0031386 protein tag activity 5/1183 15/18639 0.333333333333333 5.25190194420964 0.00179313418439879 0.034898292095274 GO:0141047 molecular tag activity 5/1183 15/18639 0.333333333333333 5.25190194420964 0.00179313418439879 0.034898292095274 GO:0005518 collagen binding 12/1183 72/18639 0.166666666666667 2.62595097210482 0.00179760296760736 0.034898292095274 GO:0003925 G protein activity 10/1183 54/18639 0.185185185185185 2.91772330233869 0.00188693714158922 0.0356694865843565 GO:0043394 proteoglycan binding 8/1183 37/18639 0.216216216216216 3.40663909894679 0.00190068312172415 0.0356694865843565 GO:0050321 tau-protein kinase activity 6/1183 22/18639 0.272727272727273 4.29701068162607 0.00199446586878363 0.0368158781680388 GO:0004722 protein serine/threonine phosphatase activity 15/1183 103/18639 0.145631067961165 2.29452026688771 0.00210620253536777 0.0381137553396315 GO:0005096 GTPase activator activity 30/1183 271/18639 0.11070110701107 1.74417407741279 0.00214812439308567 0.0381137553396315 GO:0003779 actin binding 44/1183 443/18639 0.0993227990970655 1.56490080504666 0.00216632357170197 0.0381137553396315 GO:0140789 histone phosphatase activity 18/1183 136/18639 0.132352941176471 2.08531400725971 0.00240718471341841 0.0403568984922136 GO:0120013 lipid transfer activity 11/1183 65/18639 0.169230769230769 2.66635021782951 0.00242648615491274 0.0403568984922136 GO:0001784 phosphotyrosine residue binding 9/1183 47/18639 0.191489361702128 3.0170500530566 0.00247203369865137 0.0403568984922136 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 5/1183 16/18639 0.3125 4.92365807269653 0.00247302486319959 0.0403568984922136 GO:0034450 ubiquitin-ubiquitin ligase activity 5/1183 16/18639 0.3125 4.92365807269653 0.00247302486319959 0.0403568984922136 GO:0019003 GDP binding 12/1183 75/18639 0.16 2.52091293322063 0.00256695377997979 0.0412320660082971 GO:0003714 transcription corepressor activity 24/1183 204/18639 0.117647058823529 1.85361245089752 0.00259989048542548 0.0412320660082971 GO:0019207 kinase regulator activity 31/1183 287/18639 0.10801393728223 1.70183582164284 0.00268008721820649 0.0419135862180627 GO:0016504 peptidase activator activity 10/1183 57/18639 0.175438596491228 2.76415891800507 0.00286640232064154 0.0438498682923976 GO:0004896 cytokine receptor activity 14/1183 96/18639 0.145833333333333 2.29770710059172 0.00288178530518421 0.0438498682923976 GO:1990782 protein tyrosine kinase binding 16/1183 117/18639 0.136752136752137 2.15462643865011 0.00293634732731568 0.0440843612074328 GO:0120015 sterol transfer activity 7/1183 32/18639 0.21875 3.44656065088757 0.00337492042027764 0.0500021104372713 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 11/1183 68/18639 0.161764705882353 2.54871711998409 0.00349493878750402 0.0511078061653185 GO:0004721 phosphoprotein phosphatase activity 21/1183 175/18639 0.12 1.89068469991547 0.00368903702498131 0.0530069119335664 GO:0004879 nuclear receptor activity 10/1183 59/18639 0.169491525423729 2.67045861569982 0.00371895740919338 0.0530069119335664 GO:0008139 nuclear localization sequence binding 6/1183 25/18639 0.24 3.78136939983094 0.00402063852398995 0.0558918392347245 GO:0120020 cholesterol transfer activity 6/1183 25/18639 0.24 3.78136939983094 0.00402063852398995 0.0558918392347245 GO:0098531 ligand-modulated transcription factor activity 10/1183 60/18639 0.166666666666667 2.62595097210482 0.00421455391737826 0.0578730208654625 GO:0031690 adrenergic receptor binding 5/1183 18/18639 0.277777777777778 4.37658495350803 0.00436242195855983 0.0589534983342843 GO:0005048 signal sequence binding 9/1183 51/18639 0.176470588235294 2.78041867634628 0.00439795191836579 0.0589534983342843 GO:0033192 calmodulin-dependent protein phosphatase activity 12/1183 81/18639 0.148148148148148 2.33417864187095 0.00490562572072135 0.0599400966118478 GO:0140791 histone H2AXS140 phosphatase activity 12/1183 81/18639 0.148148148148148 2.33417864187095 0.00490562572072135 0.0599400966118478 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 12/1183 81/18639 0.148148148148148 2.33417864187095 0.00490562572072135 0.0599400966118478 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 12/1183 81/18639 0.148148148148148 2.33417864187095 0.00490562572072135 0.0599400966118478 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 12/1183 81/18639 0.148148148148148 2.33417864187095 0.00490562572072135 0.0599400966118478 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 12/1183 81/18639 0.148148148148148 2.33417864187095 0.00490562572072135 0.0599400966118478 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 12/1183 81/18639 0.148148148148148 2.33417864187095 0.00490562572072135 0.0599400966118478 GO:1990439 MAP kinase serine/threonine phosphatase activity 12/1183 81/18639 0.148148148148148 2.33417864187095 0.00490562572072135 0.0599400966118478 GO:0070412 R-SMAD binding 6/1183 26/18639 0.230769230769231 3.63593211522206 0.00495064741110288 0.0599400966118478 GO:0015368 calcium:monoatomic cation antiporter activity 4/1183 12/18639 0.333333333333333 5.25190194420964 0.00529387788295896 0.0634138988958701 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 12/1183 82/18639 0.146341463414634 2.3057130486774 0.00542319415381428 0.06360954809578 GO:0033549 MAP kinase phosphatase activity 12/1183 82/18639 0.146341463414634 2.3057130486774 0.00542319415381428 0.06360954809578 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 5/1183 19/18639 0.263157894736842 4.14623837700761 0.0056152374908795 0.0638662365124275 GO:0030506 ankyrin binding 5/1183 19/18639 0.263157894736842 4.14623837700761 0.0056152374908795 0.0638662365124275 GO:0043395 heparan sulfate proteoglycan binding 5/1183 19/18639 0.263157894736842 4.14623837700761 0.0056152374908795 0.0638662365124275 GO:0051219 phosphoprotein binding 13/1183 93/18639 0.139784946236559 2.20241049273307 0.00577531904621152 0.0643890698506198 GO:0001217 DNA-binding transcription repressor activity 29/1183 278/18639 0.10431654676259 1.64358082426704 0.00588365552407458 0.0643890698506198 GO:0030020 extracellular matrix structural constituent conferring tensile strength 8/1183 44/18639 0.181818181818182 2.86467378775071 0.00588994155827161 0.0643890698506198 GO:0043014 alpha-tubulin binding 8/1183 44/18639 0.181818181818182 2.86467378775071 0.00588994155827161 0.0643890698506198 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 12/1183 83/18639 0.144578313253012 2.27793337339213 0.00598322918237556 0.0647799621091815 GO:0042562 hormone binding 13/1183 94/18639 0.138297872340426 2.17898059387421 0.00632340028851138 0.0678109402367982 GO:0015485 cholesterol binding 9/1183 54/18639 0.166666666666667 2.62595097210482 0.00648710091409933 0.0688393261330316 GO:0017018 myosin phosphatase activity 12/1183 84/18639 0.142857142857143 2.25081511894699 0.00658808396477418 0.0688393261330316 GO:0019783 ubiquitin-like protein peptidase activity 16/1183 127/18639 0.125984251968504 1.98497081355955 0.00660270623656075 0.0688393261330316 GO:0044390 ubiquitin-like protein conjugating enzyme binding 7/1183 36/18639 0.194444444444444 3.06360946745562 0.00671063220726087 0.0693226776639976 GO:0003924 GTPase activity 33/1183 331/18639 0.0996978851963746 1.57081055128929 0.00686021990100821 0.0702237055321386 GO:0070851 growth factor receptor binding 17/1183 139/18639 0.122302158273381 1.92695682845102 0.0070108459707669 0.0708926837948109 GO:0016004 phospholipase activator activity 5/1183 20/18639 0.25 3.93892645815723 0.00710174147147269 0.0708926837948109 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 16/1183 128/18639 0.125 1.96946322907861 0.00711445228136202 0.0708926837948109 GO:0031267 small GTPase binding 29/1183 283/18639 0.102473498233216 1.61454229380296 0.00749628264658131 0.0740422303513207 GO:0035591 signaling adaptor activity 16/1183 129/18639 0.124031007751938 1.95419607226405 0.00765758429869504 0.0749777384376575 GO:0004843 cysteine-type deubiquitinase activity 14/1183 108/18639 0.12962962962963 2.04240631163708 0.00833767929693604 0.0809329904168102 GO:0106222 lncRNA binding 6/1183 29/18639 0.206896551724138 3.25980120675081 0.00868349418136898 0.0835693542583032 GO:0004725 protein tyrosine phosphatase activity 13/1183 98/18639 0.13265306122449 2.09004261045077 0.00894185720593617 0.0853265357108825 GO:0016530 metallochaperone activity 4/1183 14/18639 0.285714285714286 4.50163023789397 0.00966902471433075 0.0885173647669841 GO:0019992 diacylglycerol binding 4/1183 14/18639 0.285714285714286 4.50163023789397 0.00966902471433075 0.0885173647669841 GO:0034236 protein kinase A catalytic subunit binding 4/1183 14/18639 0.285714285714286 4.50163023789397 0.00966902471433075 0.0885173647669841 GO:0042043 neurexin family protein binding 4/1183 14/18639 0.285714285714286 4.50163023789397 0.00966902471433075 0.0885173647669841 GO:0003697 single-stranded DNA binding 15/1183 121/18639 0.12396694214876 1.95318667346639 0.00966930361131354 0.0885173647669841 GO:0051721 protein phosphatase 2A binding 6/1183 30/18639 0.2 3.15114116652578 0.0102842005290418 0.0921998187509175 GO:0032934 sterol binding 10/1183 68/18639 0.147058823529412 2.3170155636219 0.0103000443120807 0.0921998187509175 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 9/1183 58/18639 0.155172413793103 2.44485090506311 0.0103659293160996 0.0921998187509175 GO:0005543 phospholipid binding 45/1183 497/18639 0.0905432595573441 1.42657296271288 0.0103990914576967 0.0921998187509175 GO:0008194 UDP-glycosyltransferase activity 17/1183 145/18639 0.117241379310345 1.84722068382546 0.0105467183102112 0.0927781626351388 GO:0004674 protein serine/threonine kinase activity 40/1183 433/18639 0.092378752886836 1.45549245567011 0.0110796511596326 0.0967107535329172 GO:0016763 pentosyltransferase activity 8/1183 49/18639 0.163265306122449 2.57236013593941 0.01133916705065 0.0982146315310144 GO:0070063 RNA polymerase binding 9/1183 59/18639 0.152542372881356 2.40341275412983 0.0115623842593426 0.0993835471451895 GO:0070325 lipoprotein particle receptor binding 6/1183 31/18639 0.193548387096774 3.04949145147656 0.0120835565214733 0.103076398811961 GO:0061578 K63-linked deubiquitinase activity 4/1183 15/18639 0.266666666666667 4.20152155536771 0.0125329849070333 0.106106323348267 GO:0005158 insulin receptor binding 5/1183 23/18639 0.217391304347826 3.42515344187585 0.0131622633586229 0.110602302550816 GO:0106310 protein serine kinase activity 34/1183 361/18639 0.0941828254847645 1.48391689282378 0.0139200680088315 0.116103678355143 GO:0101005 deubiquitinase activity 14/1183 115/18639 0.121739130434783 1.91808592745048 0.0141294274271034 0.116983347668518 GO:0016791 phosphatase activity 27/1183 273/18639 0.0989010989010989 1.55825662080945 0.0148825757601915 0.122319564277195 GO:0008234 cysteine-type peptidase activity 20/1183 187/18639 0.106951871657754 1.68510222808865 0.0154509585076143 0.125090764627774 GO:0048487 beta-tubulin binding 7/1183 42/18639 0.166666666666667 2.62595097210482 0.0156014014476399 0.125090764627774 GO:0019957 C-C chemokine binding 5/1183 24/18639 0.208333333333333 3.28243871513102 0.0157769613930698 0.125090764627774 GO:0030552 cAMP binding 5/1183 24/18639 0.208333333333333 3.28243871513102 0.0157769613930698 0.125090764627774 GO:0060229 lipase activator activity 5/1183 24/18639 0.208333333333333 3.28243871513102 0.0157769613930698 0.125090764627774 GO:0070411 I-SMAD binding 4/1183 16/18639 0.25 3.93892645815723 0.0158863049216445 0.125090764627774 GO:0005080 protein kinase C binding 8/1183 52/18639 0.153846153846154 2.42395474348137 0.0160173130791768 0.125246489771897 GO:0048156 tau protein binding 7/1183 43/18639 0.162790697674419 2.56488234484657 0.0176440330008755 0.137015042475764 GO:0005319 lipid transporter activity 19/1183 178/18639 0.106741573033708 1.68178882483118 0.0182706536695037 0.14090928788946 GO:0005496 steroid binding 13/1183 108/18639 0.12037037037037 1.89652014652015 0.0192142878358827 0.14717883063404 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 4/1183 17/18639 0.235294117647059 3.70722490179504 0.0197521822253841 0.14723725984104 GO:0031489 myosin V binding 4/1183 17/18639 0.235294117647059 3.70722490179504 0.0197521822253841 0.14723725984104 GO:0140463 chromatin-protein adaptor activity 8/1183 54/18639 0.148148148148148 2.33417864187095 0.0198236608213808 0.14723725984104 GO:0016757 glycosyltransferase activity 26/1183 267/18639 0.0973782771535581 1.53426348931967 0.0198541929969744 0.14723725984104 GO:0016209 antioxidant activity 11/1183 86/18639 0.127906976744186 2.0152646995223 0.0198757224652203 0.14723725984104 GO:0015631 tubulin binding 35/1183 385/18639 0.0909090909090909 1.43233689387536 0.020705155139656 0.150089092033996 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 26/1183 268/18639 0.0970149253731343 1.52853862555355 0.0207094262378627 0.150089092033996 GO:0043015 gamma-tubulin binding 6/1183 35/18639 0.171428571428571 2.70097814273638 0.0214929502443532 0.150089092033996 GO:0005031 tumor necrosis factor receptor activity 3/1183 10/18639 0.3 4.72671174978867 0.0218496999754314 0.150089092033996 GO:0031996 thioesterase binding 3/1183 10/18639 0.3 4.72671174978867 0.0218496999754314 0.150089092033996 GO:0043422 protein kinase B binding 3/1183 10/18639 0.3 4.72671174978867 0.0218496999754314 0.150089092033996 GO:0045322 unmethylated CpG binding 3/1183 10/18639 0.3 4.72671174978867 0.0218496999754314 0.150089092033996 GO:0019001 guanyl nucleotide binding 36/1183 400/18639 0.09 1.4180135249366 0.0219871867605883 0.150089092033996 GO:0032561 guanyl ribonucleotide binding 36/1183 400/18639 0.09 1.4180135249366 0.0219871867605883 0.150089092033996 GO:0001637 G protein-coupled chemoattractant receptor activity 5/1183 26/18639 0.192307692307692 3.02994342935171 0.0219935170387295 0.150089092033996 GO:0004950 chemokine receptor activity 5/1183 26/18639 0.192307692307692 3.02994342935171 0.0219935170387295 0.150089092033996 GO:0050750 low-density lipoprotein particle receptor binding 5/1183 26/18639 0.192307692307692 3.02994342935171 0.0219935170387295 0.150089092033996 GO:0097602 cullin family protein binding 5/1183 26/18639 0.192307692307692 3.02994342935171 0.0219935170387295 0.150089092033996 GO:0004715 non-membrane spanning protein tyrosine kinase activity 7/1183 45/18639 0.155555555555556 2.4508875739645 0.022279803322672 0.151126858682703 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 4/1183 18/18639 0.222222222222222 3.50126796280642 0.0241492565873339 0.160899780575964 GO:0070064 proline-rich region binding 4/1183 18/18639 0.222222222222222 3.50126796280642 0.0241492565873339 0.160899780575964 GO:1990381 ubiquitin-specific protease binding 4/1183 18/18639 0.222222222222222 3.50126796280642 0.0241492565873339 0.160899780575964 GO:0015085 calcium ion transmembrane transporter activity 16/1183 147/18639 0.108843537414966 1.71490675729294 0.0243922665105018 0.161562894651912 GO:0003727 single-stranded RNA binding 11/1183 89/18639 0.123595505617978 1.94733442875189 0.025016987795601 0.162827330970212 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 11/1183 89/18639 0.123595505617978 1.94733442875189 0.025016987795601 0.162827330970212 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 11/1183 89/18639 0.123595505617978 1.94733442875189 0.025016987795601 0.162827330970212 GO:0005525 GTP binding 34/1183 378/18639 0.0899470899470899 1.41717988970736 0.0256291466826773 0.165173127814546 GO:0019209 kinase activator activity 16/1183 148/18639 0.108108108108108 1.7033195494734 0.0257998246046026 0.165173127814546 GO:0019838 growth factor binding 15/1183 136/18639 0.110294117647059 1.73776167271642 0.0258174693564477 0.165173127814546 GO:0015078 proton transmembrane transporter activity 19/1183 185/18639 0.102702702702703 1.61815357199973 0.0261672168236556 0.166464893465742 GO:0140793 histone H2AXY142 phosphatase activity 11/1183 90/18639 0.122222222222222 1.92569737954353 0.0269275958242953 0.170339735382902 GO:0030551 cyclic nucleotide binding 6/1183 37/18639 0.162162162162162 2.55497932421009 0.0276655029210399 0.174029923402743 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 3/1183 11/18639 0.272727272727273 4.29701068162607 0.0286504817946643 0.176286571042579 GO:0035252 UDP-xylosyltransferase activity 3/1183 11/18639 0.272727272727273 4.29701068162607 0.0286504817946643 0.176286571042579 GO:0042285 xylosyltransferase activity 3/1183 11/18639 0.272727272727273 4.29701068162607 0.0286504817946643 0.176286571042579 GO:0097493 structural molecule activity conferring elasticity 3/1183 11/18639 0.272727272727273 4.29701068162607 0.0286504817946643 0.176286571042579 GO:0070003 threonine-type peptidase activity 4/1183 19/18639 0.210526315789474 3.31699070160609 0.0290916616797217 0.176415070982736 GO:1990380 K48-linked deubiquitinase activity 4/1183 19/18639 0.210526315789474 3.31699070160609 0.0290916616797217 0.176415070982736 GO:0061980 regulatory RNA binding 8/1183 58/18639 0.137931034482759 2.17320080450054 0.0292862095717594 0.176415070982736 GO:0048306 calcium-dependent protein binding 10/1183 80/18639 0.125 1.96946322907861 0.0295971248139747 0.176415070982736 GO:0046966 nuclear thyroid hormone receptor binding 5/1183 28/18639 0.178571428571429 2.81351889868373 0.0296114106711697 0.176415070982736 GO:0141052 histone H3 demethylase activity 5/1183 28/18639 0.178571428571429 2.81351889868373 0.0296114106711697 0.176415070982736 GO:0035401 histone H3Y41 kinase activity 13/1183 115/18639 0.11304347826087 1.78107978977544 0.0304752592426102 0.179660428833398 GO:0140801 histone H2AXY142 kinase activity 13/1183 115/18639 0.11304347826087 1.78107978977544 0.0304752592426102 0.179660428833398 GO:0042826 histone deacetylase binding 14/1183 127/18639 0.110236220472441 1.7368494618646 0.0306874894420549 0.179969339123718 GO:0043178 alcohol binding 11/1183 92/18639 0.119565217391304 1.88383439303172 0.0310604959937947 0.18121304916587 GO:0001786 phosphatidylserine binding 8/1183 59/18639 0.135593220338983 2.13636689255985 0.0320664174639031 0.186117453939974 GO:0004713 protein tyrosine kinase activity 15/1183 140/18639 0.107142857142857 1.68811133921024 0.0323834500736809 0.186993665553665 GO:0004629 phospholipase C activity 5/1183 29/18639 0.172413793103448 2.71650100562567 0.0339713932732115 0.194171516881402 GO:0035250 UDP-galactosyltransferase activity 5/1183 29/18639 0.172413793103448 2.71650100562567 0.0339713932732115 0.194171516881402 GO:0019887 protein kinase regulator activity 24/1183 255/18639 0.0941176470588235 1.48288996071802 0.0347404652552823 0.197564464027514 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 41/1183 484/18639 0.0847107438016529 1.33467756020204 0.0364297695109852 0.20111252207019 GO:0010853 cyclase activator activity 3/1183 12/18639 0.25 3.93892645815723 0.0364360164318994 0.20111252207019 GO:0035014 phosphatidylinositol 3-kinase regulator activity 3/1183 12/18639 0.25 3.93892645815723 0.0364360164318994 0.20111252207019 GO:0035197 siRNA binding 3/1183 12/18639 0.25 3.93892645815723 0.0364360164318994 0.20111252207019 GO:0035259 nuclear glucocorticoid receptor binding 3/1183 12/18639 0.25 3.93892645815723 0.0364360164318994 0.20111252207019 GO:0070410 co-SMAD binding 3/1183 12/18639 0.25 3.93892645815723 0.0364360164318994 0.20111252207019 GO:0015026 coreceptor activity 8/1183 61/18639 0.131147540983607 2.06632207641035 0.0381550880062622 0.209548772267419 GO:0005262 calcium channel activity 14/1183 131/18639 0.106870229007634 1.68381589050996 0.0385166307305584 0.209548772267419 GO:0031624 ubiquitin conjugating enzyme binding 5/1183 30/18639 0.166666666666667 2.62595097210482 0.0387088318220454 0.209548772267419 GO:0032452 histone demethylase activity 5/1183 30/18639 0.166666666666667 2.62595097210482 0.0387088318220454 0.209548772267419 GO:0032451 demethylase activity 6/1183 40/18639 0.15 2.36335587489434 0.0389432083922448 0.209808864352477 GO:0072542 protein phosphatase activator activity 4/1183 21/18639 0.19047619047619 3.00108682526265 0.0406472197929654 0.216913599463882 GO:0140312 cargo adaptor activity 4/1183 21/18639 0.19047619047619 3.00108682526265 0.0406472197929654 0.216913599463882 GO:0061650 ubiquitin-like protein conjugating enzyme activity 6/1183 41/18639 0.146341463414634 2.3057130486774 0.0432650637820408 0.228715783185812 GO:0140828 metal cation:monoatomic cation antiporter activity 6/1183 41/18639 0.146341463414634 2.3057130486774 0.0432650637820408 0.228715783185812 GO:0140457 protein demethylase activity 5/1183 31/18639 0.161290322580645 2.54124287623047 0.0438290770721554 0.230614676557229 GO:0001216 DNA-binding transcription activator activity 41/1183 491/18639 0.0835030549898167 1.31564957054539 0.0440558794694433 0.230729861779503 GO:0030159 signaling receptor complex adaptor activity 7/1183 52/18639 0.134615384615385 2.1209604005462 0.044949829207003 0.233396101886099 GO:0005035 death receptor activity 3/1183 13/18639 0.230769230769231 3.63593211522206 0.0451868119104525 0.233396101886099 GO:0071837 HMG box domain binding 3/1183 13/18639 0.230769230769231 3.63593211522206 0.0451868119104525 0.233396101886099 GO:0140996 histone H3 kinase activity 31/1183 357/18639 0.0868347338935574 1.3681425232815 0.047618913498258 0.244835144287847 GO:0035198 miRNA binding 6/1183 42/18639 0.142857142857143 2.25081511894699 0.0478756741711077 0.245036405075761 GO:0005246 calcium channel regulator activity 7/1183 53/18639 0.132075471698113 2.08094227978118 0.049074039756348 0.250033342830986 GO:0008378 galactosyltransferase activity 5/1183 32/18639 0.15625 2.46182903634827 0.0493357132381851 0.250234293271155 GO:0002020 protease binding 14/1183 136/18639 0.102941176470588 1.62191089453533 0.0501848572346353 0.253399772404481 GO:0016651 oxidoreductase activity, acting on NAD(P)H 10/1183 88/18639 0.113636363636364 1.79042111734419 0.0518367291258128 0.260572129444934 GO:0035173 histone kinase activity 31/1183 360/18639 0.0861111111111111 1.35674133558749 0.0521686736911321 0.261075229227621 GO:0016493 C-C chemokine receptor activity 4/1183 23/18639 0.173913043478261 2.74012275350068 0.0544474360551989 0.268641477261409 GO:0031681 G-protein beta-subunit binding 4/1183 23/18639 0.173913043478261 2.74012275350068 0.0544474360551989 0.268641477261409 GO:0044548 S100 protein binding 3/1183 14/18639 0.214285714285714 3.37622267842048 0.0548734811457585 0.268641477261409 GO:0071933 Arp2/3 complex binding 3/1183 14/18639 0.214285714285714 3.37622267842048 0.0548734811457585 0.268641477261409 GO:0098847 sequence-specific single stranded DNA binding 3/1183 14/18639 0.214285714285714 3.37622267842048 0.0548734811457585 0.268641477261409 GO:0030295 protein kinase activator activity 14/1183 139/18639 0.100719424460432 1.58690562343025 0.0582538829439144 0.283956156687652 GO:0000287 magnesium ion binding 21/1183 230/18639 0.091304347826087 1.43856444558786 0.0597535867327587 0.28876626034801 GO:0005085 guanyl-nucleotide exchange factor activity 21/1183 230/18639 0.091304347826087 1.43856444558786 0.0597535867327587 0.28876626034801 GO:0035091 phosphatidylinositol binding 25/1183 284/18639 0.0880281690140845 1.38694593597085 0.0612236554141196 0.293494020608617 GO:0008376 acetylgalactosaminyltransferase activity 5/1183 34/18639 0.147058823529412 2.3170155636219 0.0615138444614864 0.293494020608617 GO:0015035 protein-disulfide reductase activity 5/1183 34/18639 0.147058823529412 2.3170155636219 0.0615138444614864 0.293494020608617 GO:0035035 histone acetyltransferase binding 4/1183 24/18639 0.166666666666667 2.62595097210482 0.0621815309876247 0.295427864523483 GO:0009055 electron transfer activity 12/1183 116/18639 0.103448275862069 1.6299006033754 0.0643542996155621 0.304466140197996 GO:0141003 histone H2AX kinase activity 30/1183 354/18639 0.0847457627118644 1.33522930784991 0.0653194691464016 0.304571857278203 GO:1990841 promoter-specific chromatin binding 8/1183 68/18639 0.117647058823529 1.85361245089752 0.0653542451379581 0.304571857278203 GO:0055105 ubiquitin-protein transferase inhibitor activity 3/1183 15/18639 0.2 3.15114116652578 0.0654586052054398 0.304571857278203 GO:0120283 protein serine/threonine kinase binding 3/1183 15/18639 0.2 3.15114116652578 0.0654586052054398 0.304571857278203 GO:0004601 peroxidase activity 7/1183 57/18639 0.12280701754386 1.93491124260355 0.067912341184475 0.314652363435993 GO:0010485 histone H4 acetyltransferase activity 5/1183 35/18639 0.142857142857143 2.25081511894699 0.0681839934976753 0.314652363435993 GO:0030276 clathrin binding 6/1183 46/18639 0.130434782608696 2.05509206512551 0.0692528167029277 0.318280292275496 GO:0003707 nuclear steroid receptor activity 4/1183 25/18639 0.16 2.52091293322063 0.0704606717261551 0.318868957868239 GO:0004709 MAP kinase kinase kinase activity 4/1183 25/18639 0.16 2.52091293322063 0.0704606717261551 0.318868957868239 GO:0019211 phosphatase activator activity 4/1183 25/18639 0.16 2.52091293322063 0.0704606717261551 0.318868957868239 GO:0001618 virus receptor activity 9/1183 81/18639 0.111111111111111 1.75063398140321 0.0706267964887875 0.318868957868239 GO:1901681 sulfur compound binding 24/1183 275/18639 0.0872727272727273 1.37504341812034 0.070796837892593 0.318868957868239 GO:0022853 active monoatomic ion transmembrane transporter activity 12/1183 118/18639 0.101694915254237 1.60227516941989 0.0713109377816993 0.319904844391209 GO:0140104 molecular carrier activity 22/1183 249/18639 0.0883534136546185 1.39207039485075 0.0729986447475339 0.32617648407033 GO:0061659 ubiquitin-like protein ligase activity 31/1183 372/18639 0.0833333333333333 1.31297548605241 0.0735470761308759 0.327328093768246 GO:0140272 exogenous protein binding 9/1183 82/18639 0.109756097560976 1.72928478650805 0.0750969211293751 0.331353605279877 GO:0000993 RNA polymerase II complex binding 5/1183 36/18639 0.138888888888889 2.18829247675402 0.0752379579566919 0.331353605279877 GO:0005504 fatty acid binding 6/1183 47/18639 0.127659574468085 2.01136670203773 0.0753343898327251 0.331353605279877 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 7/1183 59/18639 0.11864406779661 1.86932103098987 0.0787530603112834 0.343312556767916 GO:0031593 polyubiquitin modification-dependent protein binding 7/1183 59/18639 0.11864406779661 1.86932103098987 0.0787530603112834 0.343312556767916 GO:0004435 phosphatidylinositol phospholipase C activity 4/1183 26/18639 0.153846153846154 2.42395474348137 0.0792728816693234 0.343312556767916 GO:0005160 transforming growth factor beta receptor binding 4/1183 26/18639 0.153846153846154 2.42395474348137 0.0792728816693234 0.343312556767916 GO:0001540 amyloid-beta binding 9/1183 83/18639 0.108433734939759 1.7084500300441 0.079736929113134 0.343999165445935 GO:0140693 molecular condensate scaffold activity 6/1183 48/18639 0.125 1.96946322907861 0.0817091209185543 0.351162099825543 GO:0042805 actinin binding 5/1183 37/18639 0.135135135135135 2.12914943684174 0.0826711540560125 0.353945701395704 GO:0061134 peptidase regulator activity 20/1183 226/18639 0.0884955752212389 1.39431025067512 0.0831650175102379 0.354711400441394 GO:0051117 ATPase binding 9/1183 84/18639 0.107142857142857 1.68811133921024 0.084546994039639 0.359244963353334 GO:0015297 antiporter activity 13/1183 135/18639 0.0962962962962963 1.51721611721612 0.0873478802407126 0.369029849240558 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 3/1183 17/18639 0.176470588235294 2.78041867634628 0.08914397779168 0.369029849240558 GO:0005092 GDP-dissociation inhibitor activity 3/1183 17/18639 0.176470588235294 2.78041867634628 0.08914397779168 0.369029849240558 GO:0008429 phosphatidylethanolamine binding 3/1183 17/18639 0.176470588235294 2.78041867634628 0.08914397779168 0.369029849240558 GO:0032183 SUMO binding 3/1183 17/18639 0.176470588235294 2.78041867634628 0.08914397779168 0.369029849240558 GO:0036041 long-chain fatty acid binding 3/1183 17/18639 0.176470588235294 2.78041867634628 0.08914397779168 0.369029849240558 GO:0070403 NAD+ binding 3/1183 17/18639 0.176470588235294 2.78041867634628 0.08914397779168 0.369029849240558 GO:0005539 glycosaminoglycan binding 21/1183 242/18639 0.0867768595041322 1.36723067142648 0.0903931054020118 0.372830170998774 GO:0016922 nuclear receptor binding 13/1183 137/18639 0.0948905109489051 1.4950669768188 0.09531118624834 0.390322859131968 GO:0048020 CCR chemokine receptor binding 6/1183 50/18639 0.12 1.89068469991547 0.0953275188821414 0.390322859131968 GO:0003684 damaged DNA binding 8/1183 74/18639 0.108108108108108 1.7033195494734 0.0963063863274345 0.392902141321345 GO:0043021 ribonucleoprotein complex binding 16/1183 177/18639 0.0903954802259887 1.4242445950399 0.0974322095602071 0.39581116545031 GO:0016755 aminoacyltransferase activity 39/1183 496/18639 0.0786290322580645 1.23885590216235 0.0977224724646414 0.39581116545031 GO:0036408 histone H3K14 acetyltransferase activity 4/1183 28/18639 0.142857142857143 2.25081511894699 0.0984355295911019 0.39585145114136 GO:0051537 2 iron, 2 sulfur cluster binding 4/1183 28/18639 0.142857142857143 2.25081511894699 0.0984355295911019 0.39585145114136 GO:0000400 four-way junction DNA binding 3/1183 18/18639 0.166666666666667 2.62595097210482 0.102142922032549 0.400741917103312 GO:0000900 mRNA regulatory element binding translation repressor activity 3/1183 18/18639 0.166666666666667 2.62595097210482 0.102142922032549 0.400741917103312 GO:0035615 clathrin adaptor activity 3/1183 18/18639 0.166666666666667 2.62595097210482 0.102142922032549 0.400741917103312 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 3/1183 18/18639 0.166666666666667 2.62595097210482 0.102142922032549 0.400741917103312 GO:0050811 GABA receptor binding 3/1183 18/18639 0.166666666666667 2.62595097210482 0.102142922032549 0.400741917103312 GO:0070628 proteasome binding 3/1183 18/18639 0.166666666666667 2.62595097210482 0.102142922032549 0.400741917103312 GO:1901611 phosphatidylglycerol binding 3/1183 18/18639 0.166666666666667 2.62595097210482 0.102142922032549 0.400741917103312 GO:0003743 translation initiation factor activity 6/1183 51/18639 0.117647058823529 1.85361245089752 0.102563845743685 0.400996146900657 GO:0015036 disulfide oxidoreductase activity 5/1183 40/18639 0.125 1.96946322907861 0.107179361528762 0.417591560835246 GO:0003785 actin monomer binding 4/1183 29/18639 0.137931034482759 2.17320080450054 0.108749791401964 0.417925819517446 GO:0010484 histone H3 acetyltransferase activity 4/1183 29/18639 0.137931034482759 2.17320080450054 0.108749791401964 0.417925819517446 GO:0016417 S-acyltransferase activity 4/1183 29/18639 0.137931034482759 2.17320080450054 0.108749791401964 0.417925819517446 GO:0043236 laminin binding 4/1183 29/18639 0.137931034482759 2.17320080450054 0.108749791401964 0.417925819517446 GO:0004857 enzyme inhibitor activity 33/1183 416/18639 0.0793269230769231 1.24985166460758 0.109814485694338 0.420582009836138 GO:0051540 metal cluster binding 8/1183 77/18639 0.103896103896104 1.63695645014326 0.114429943042193 0.434146820723556 GO:0003756 protein disulfide isomerase activity 3/1183 19/18639 0.157894736842105 2.48774302620456 0.115840033348704 0.434146820723556 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 3/1183 19/18639 0.157894736842105 2.48774302620456 0.115840033348704 0.434146820723556 GO:0022821 solute:potassium antiporter activity 3/1183 19/18639 0.157894736842105 2.48774302620456 0.115840033348704 0.434146820723556 GO:0140036 ubiquitin-modified protein reader activity 3/1183 19/18639 0.157894736842105 2.48774302620456 0.115840033348704 0.434146820723556 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 5/1183 41/18639 0.121951219512195 1.9214275405645 0.116056347326918 0.434146820723556 GO:0042287 MHC protein binding 5/1183 41/18639 0.121951219512195 1.9214275405645 0.116056347326918 0.434146820723556 GO:0038024 cargo receptor activity 7/1183 65/18639 0.107692307692308 1.69676832043696 0.116897698445491 0.434146820723556 GO:0051018 protein kinase A binding 6/1183 53/18639 0.113207547169811 1.78366481124101 0.11786654866282 0.434146820723556 GO:0001968 fibronectin binding 4/1183 30/18639 0.133333333333333 2.10076077768385 0.119525323645029 0.434146820723556 GO:0035925 mRNA 3'-UTR AU-rich region binding 4/1183 30/18639 0.133333333333333 2.10076077768385 0.119525323645029 0.434146820723556 GO:0043995 histone H4K5 acetyltransferase activity 4/1183 30/18639 0.133333333333333 2.10076077768385 0.119525323645029 0.434146820723556 GO:0043996 histone H4K8 acetyltransferase activity 4/1183 30/18639 0.133333333333333 2.10076077768385 0.119525323645029 0.434146820723556 GO:0043997 histone H4K12 acetyltransferase activity 4/1183 30/18639 0.133333333333333 2.10076077768385 0.119525323645029 0.434146820723556 GO:0048019 receptor antagonist activity 4/1183 30/18639 0.133333333333333 2.10076077768385 0.119525323645029 0.434146820723556 GO:0070566 adenylyltransferase activity 4/1183 30/18639 0.133333333333333 2.10076077768385 0.119525323645029 0.434146820723556 GO:0016758 hexosyltransferase activity 17/1183 197/18639 0.0862944162436548 1.35962943733346 0.122420308838045 0.441508758016098 GO:0072341 modified amino acid binding 9/1183 91/18639 0.0989010989010989 1.55825662080945 0.122934619439543 0.441508758016098 GO:0019787 ubiquitin-like protein transferase activity 37/1183 479/18639 0.0772442588726514 1.21703782005693 0.124916967566628 0.441508758016098 GO:0004402 histone acetyltransferase activity 5/1183 42/18639 0.119047619047619 1.87567926578916 0.125269951807433 0.441508758016098 GO:0043175 RNA polymerase core enzyme binding 5/1183 42/18639 0.119047619047619 1.87567926578916 0.125269951807433 0.441508758016098 GO:0033293 monocarboxylic acid binding 8/1183 79/18639 0.10126582278481 1.5955145146966 0.127462257057651 0.441508758016098 GO:0004862 cAMP-dependent protein kinase inhibitor activity 2/1183 10/18639 0.2 3.15114116652578 0.129124691093543 0.441508758016098 GO:0004935 adrenergic receptor activity 2/1183 10/18639 0.2 3.15114116652578 0.129124691093543 0.441508758016098 GO:0008140 cAMP response element binding protein binding 2/1183 10/18639 0.2 3.15114116652578 0.129124691093543 0.441508758016098 GO:0008641 ubiquitin-like modifier activating enzyme activity 2/1183 10/18639 0.2 3.15114116652578 0.129124691093543 0.441508758016098 GO:0015279 store-operated calcium channel activity 2/1183 10/18639 0.2 3.15114116652578 0.129124691093543 0.441508758016098 GO:0035256 G protein-coupled glutamate receptor binding 2/1183 10/18639 0.2 3.15114116652578 0.129124691093543 0.441508758016098 GO:0035374 chondroitin sulfate binding 2/1183 10/18639 0.2 3.15114116652578 0.129124691093543 0.441508758016098 GO:0050308 sugar-phosphatase activity 2/1183 10/18639 0.2 3.15114116652578 0.129124691093543 0.441508758016098 GO:0051864 histone H3K36 demethylase activity 2/1183 10/18639 0.2 3.15114116652578 0.129124691093543 0.441508758016098 GO:0051880 G-quadruplex DNA binding 2/1183 10/18639 0.2 3.15114116652578 0.129124691093543 0.441508758016098 GO:0070097 delta-catenin binding 2/1183 10/18639 0.2 3.15114116652578 0.129124691093543 0.441508758016098 GO:0070513 death domain binding 2/1183 10/18639 0.2 3.15114116652578 0.129124691093543 0.441508758016098 GO:0098505 G-rich strand telomeric DNA binding 2/1183 10/18639 0.2 3.15114116652578 0.129124691093543 0.441508758016098 GO:0001972 retinoic acid binding 3/1183 20/18639 0.15 2.36335587489434 0.130178425986984 0.441508758016098 GO:0010851 cyclase regulator activity 3/1183 20/18639 0.15 2.36335587489434 0.130178425986984 0.441508758016098 GO:0061608 nuclear import signal receptor activity 3/1183 20/18639 0.15 2.36335587489434 0.130178425986984 0.441508758016098 GO:0005452 solute:inorganic anion antiporter activity 4/1183 31/18639 0.129032258064516 2.03299430098438 0.130739582396566 0.442080389725324 GO:0008201 heparin binding 15/1183 172/18639 0.0872093023255814 1.37404411331066 0.131689692657034 0.443511923561556 GO:0061630 ubiquitin protein ligase activity 28/1183 353/18639 0.0793201133144476 1.24974437199323 0.131950705500108 0.443511923561556 GO:0008375 acetylglucosaminyltransferase activity 5/1183 43/18639 0.116279069767442 1.83205881774755 0.134808353036176 0.451768468805756 GO:0140030 modification-dependent protein binding 15/1183 173/18639 0.0867052023121387 1.36610166178863 0.136254334538511 0.455259289882383 GO:0005548 phospholipid transporter activity 7/1183 68/18639 0.102941176470588 1.62191089453533 0.13899938090804 0.461691159004285 GO:0030145 manganese ion binding 7/1183 68/18639 0.102941176470588 1.62191089453533 0.13899938090804 0.461691159004285 GO:0030971 receptor tyrosine kinase binding 8/1183 81/18639 0.0987654320987654 1.55611909458063 0.141228135280299 0.464721306677082 GO:0070717 poly-purine tract binding 4/1183 32/18639 0.125 1.96946322907861 0.142368706562048 0.464721306677082 GO:0140142 nucleocytoplasmic carrier activity 4/1183 32/18639 0.125 1.96946322907861 0.142368706562048 0.464721306677082 GO:0019212 phosphatase inhibitor activity 6/1183 56/18639 0.107142857142857 1.68811133921024 0.142801748440395 0.464721306677082 GO:0001046 core promoter sequence-specific DNA binding 5/1183 44/18639 0.113636363636364 1.79042111734419 0.144658850967764 0.464721306677082 GO:0030547 signaling receptor inhibitor activity 5/1183 44/18639 0.113636363636364 1.79042111734419 0.144658850967764 0.464721306677082 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 3/1183 21/18639 0.142857142857143 2.25081511894699 0.145100293685988 0.464721306677082 GO:0051010 microtubule plus-end binding 3/1183 21/18639 0.142857142857143 2.25081511894699 0.145100293685988 0.464721306677082 GO:0008083 growth factor activity 14/1183 162/18639 0.0864197530864197 1.36160420775805 0.148882380241558 0.464721306677082 GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity 2/1183 11/18639 0.181818181818182 2.86467378775071 0.151452293159961 0.464721306677082 GO:0008432 JUN kinase binding 2/1183 11/18639 0.181818181818182 2.86467378775071 0.151452293159961 0.464721306677082 GO:0008526 phosphatidylinositol transfer activity 2/1183 11/18639 0.181818181818182 2.86467378775071 0.151452293159961 0.464721306677082 GO:0010854 adenylate cyclase regulator activity 2/1183 11/18639 0.181818181818182 2.86467378775071 0.151452293159961 0.464721306677082 GO:0019107 myristoyltransferase activity 2/1183 11/18639 0.181818181818182 2.86467378775071 0.151452293159961 0.464721306677082 GO:0019203 carbohydrate phosphatase activity 2/1183 11/18639 0.181818181818182 2.86467378775071 0.151452293159961 0.464721306677082 GO:0032050 clathrin heavy chain binding 2/1183 11/18639 0.181818181818182 2.86467378775071 0.151452293159961 0.464721306677082 GO:0034056 estrogen response element binding 2/1183 11/18639 0.181818181818182 2.86467378775071 0.151452293159961 0.464721306677082 GO:0034713 type I transforming growth factor beta receptor binding 2/1183 11/18639 0.181818181818182 2.86467378775071 0.151452293159961 0.464721306677082 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 2/1183 11/18639 0.181818181818182 2.86467378775071 0.151452293159961 0.464721306677082 GO:0042608 T cell receptor binding 2/1183 11/18639 0.181818181818182 2.86467378775071 0.151452293159961 0.464721306677082 GO:0048101 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity 2/1183 11/18639 0.181818181818182 2.86467378775071 0.151452293159961 0.464721306677082 GO:0048185 activin binding 2/1183 11/18639 0.181818181818182 2.86467378775071 0.151452293159961 0.464721306677082 GO:0050786 RAGE receptor binding 2/1183 11/18639 0.181818181818182 2.86467378775071 0.151452293159961 0.464721306677082 GO:0070990 snRNP binding 2/1183 11/18639 0.181818181818182 2.86467378775071 0.151452293159961 0.464721306677082 GO:0140031 phosphorylation-dependent protein binding 2/1183 11/18639 0.181818181818182 2.86467378775071 0.151452293159961 0.464721306677082 GO:0140537 transcription regulator activator activity 2/1183 11/18639 0.181818181818182 2.86467378775071 0.151452293159961 0.464721306677082 GO:0140857 histone H3T45 kinase activity 20/1183 246/18639 0.0813008130081301 1.28095169370967 0.153003698824887 0.464721306677082 GO:0140303 intramembrane lipid transporter activity 5/1183 45/18639 0.111111111111111 1.75063398140321 0.154807962810836 0.464721306677082 GO:0016779 nucleotidyltransferase activity 12/1183 136/18639 0.0882352941176471 1.39020933817314 0.155040822751357 0.464721306677082 GO:0030165 PDZ domain binding 8/1183 83/18639 0.0963855421686747 1.51862224892809 0.155699111901412 0.464721306677082 GO:0033218 amide binding 20/1183 247/18639 0.0809716599190283 1.27576565446388 0.15716870185834 0.464721306677082 GO:0035403 histone H3T6 kinase activity 20/1183 247/18639 0.0809716599190283 1.27576565446388 0.15716870185834 0.464721306677082 GO:0008093 cytoskeletal anchor activity 3/1183 22/18639 0.136363636363636 2.14850534081303 0.160547591738352 0.464721306677082 GO:0032931 histone H3K56 acetyltransferase activity 3/1183 22/18639 0.136363636363636 2.14850534081303 0.160547591738352 0.464721306677082 GO:0043992 histone H3K9 acetyltransferase activity 3/1183 22/18639 0.136363636363636 2.14850534081303 0.160547591738352 0.464721306677082 GO:0043993 histone H3K18 acetyltransferase activity 3/1183 22/18639 0.136363636363636 2.14850534081303 0.160547591738352 0.464721306677082 GO:0043994 histone H3K23 acetyltransferase activity 3/1183 22/18639 0.136363636363636 2.14850534081303 0.160547591738352 0.464721306677082 GO:0043999 histone H2AK5 acetyltransferase activity 3/1183 22/18639 0.136363636363636 2.14850534081303 0.160547591738352 0.464721306677082 GO:0044012 histone H2AK9 acetyltransferase activity 3/1183 22/18639 0.136363636363636 2.14850534081303 0.160547591738352 0.464721306677082 GO:0044014 histone H2BK5 acetyltransferase activity 3/1183 22/18639 0.136363636363636 2.14850534081303 0.160547591738352 0.464721306677082 GO:0044015 histone H2BK12 acetyltransferase activity 3/1183 22/18639 0.136363636363636 2.14850534081303 0.160547591738352 0.464721306677082 GO:0044016 histone H3K4 acetyltransferase activity 3/1183 22/18639 0.136363636363636 2.14850534081303 0.160547591738352 0.464721306677082 GO:0044017 histone H3K27 acetyltransferase activity 3/1183 22/18639 0.136363636363636 2.14850534081303 0.160547591738352 0.464721306677082 GO:0044018 histone H3K36 acetyltransferase activity 3/1183 22/18639 0.136363636363636 2.14850534081303 0.160547591738352 0.464721306677082 GO:0046972 histone H4K16 acetyltransferase activity 3/1183 22/18639 0.136363636363636 2.14850534081303 0.160547591738352 0.464721306677082 GO:0061133 endopeptidase activator activity 3/1183 22/18639 0.136363636363636 2.14850534081303 0.160547591738352 0.464721306677082 GO:0070034 telomerase RNA binding 3/1183 22/18639 0.136363636363636 2.14850534081303 0.160547591738352 0.464721306677082 GO:0140035 ubiquitin-like protein reader activity 3/1183 22/18639 0.136363636363636 2.14850534081303 0.160547591738352 0.464721306677082 GO:0140517 protein-RNA adaptor activity 3/1183 22/18639 0.136363636363636 2.14850534081303 0.160547591738352 0.464721306677082 GO:0140908 histone H3K122 acetyltransferase activity 3/1183 22/18639 0.136363636363636 2.14850534081303 0.160547591738352 0.464721306677082 GO:0005516 calmodulin binding 17/1183 207/18639 0.0821256038647343 1.29394685581977 0.166333420248261 0.469732634969904 GO:0052866 phosphatidylinositol phosphate phosphatase activity 4/1183 34/18639 0.117647058823529 1.85361245089752 0.166770946088538 0.469732634969904 GO:0070888 E-box binding 6/1183 59/18639 0.101694915254237 1.60227516941989 0.169930507367449 0.469732634969904 GO:0042379 chemokine receptor binding 7/1183 72/18639 0.0972222222222222 1.53180473372781 0.171337513906243 0.469732634969904 GO:0061775 cohesin loader activity 13/1183 153/18639 0.0849673202614379 1.33872010342599 0.174205625557401 0.469732634969904 GO:0000340 RNA 7-methylguanosine cap binding 2/1183 12/18639 0.166666666666667 2.62595097210482 0.174455548505573 0.469732634969904 GO:0005025 transforming growth factor beta receptor activity, type I 2/1183 12/18639 0.166666666666667 2.62595097210482 0.174455548505573 0.469732634969904 GO:0005026 transforming growth factor beta receptor activity, type II 2/1183 12/18639 0.166666666666667 2.62595097210482 0.174455548505573 0.469732634969904 GO:0005095 GTPase inhibitor activity 2/1183 12/18639 0.166666666666667 2.62595097210482 0.174455548505573 0.469732634969904 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 2/1183 12/18639 0.166666666666667 2.62595097210482 0.174455548505573 0.469732634969904 GO:0008603 cAMP-dependent protein kinase regulator activity 2/1183 12/18639 0.166666666666667 2.62595097210482 0.174455548505573 0.469732634969904 GO:0016361 activin receptor activity, type I 2/1183 12/18639 0.166666666666667 2.62595097210482 0.174455548505573 0.469732634969904 GO:0016362 activin receptor activity, type II 2/1183 12/18639 0.166666666666667 2.62595097210482 0.174455548505573 0.469732634969904 GO:0017002 activin receptor activity 2/1183 12/18639 0.166666666666667 2.62595097210482 0.174455548505573 0.469732634969904 GO:0043047 single-stranded telomeric DNA binding 2/1183 12/18639 0.166666666666667 2.62595097210482 0.174455548505573 0.469732634969904 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 2/1183 12/18639 0.166666666666667 2.62595097210482 0.174455548505573 0.469732634969904 GO:0070679 inositol 1,4,5 trisphosphate binding 2/1183 12/18639 0.166666666666667 2.62595097210482 0.174455548505573 0.469732634969904 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 2/1183 12/18639 0.166666666666667 2.62595097210482 0.174455548505573 0.469732634969904 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 2/1183 12/18639 0.166666666666667 2.62595097210482 0.174455548505573 0.469732634969904 GO:0140829 bicarbonate:monoatomic anion antiporter activity 2/1183 12/18639 0.166666666666667 2.62595097210482 0.174455548505573 0.469732634969904 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 2/1183 12/18639 0.166666666666667 2.62595097210482 0.174455548505573 0.469732634969904 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 2/1183 12/18639 0.166666666666667 2.62595097210482 0.174455548505573 0.469732634969904 GO:0140900 chloride:bicarbonate antiporter activity 2/1183 12/18639 0.166666666666667 2.62595097210482 0.174455548505573 0.469732634969904 GO:1990247 N6-methyladenosine-containing RNA reader activity 2/1183 12/18639 0.166666666666667 2.62595097210482 0.174455548505573 0.469732634969904 GO:1990459 transferrin receptor binding 2/1183 12/18639 0.166666666666667 2.62595097210482 0.174455548505573 0.469732634969904 GO:1990817 poly(A) RNA polymerase activity 2/1183 12/18639 0.166666666666667 2.62595097210482 0.174455548505573 0.469732634969904 GO:0043495 protein-membrane adaptor activity 5/1183 47/18639 0.106382978723404 1.67613891836478 0.17594474666442 0.469732634969904 GO:0061733 protein-lysine-acetyltransferase activity 5/1183 47/18639 0.106382978723404 1.67613891836478 0.17594474666442 0.469732634969904 GO:1990518 single-stranded 3'-5' DNA helicase activity 5/1183 47/18639 0.106382978723404 1.67613891836478 0.17594474666442 0.469732634969904 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 3/1183 23/18639 0.130434782608696 2.05509206512551 0.176462615090825 0.469732634969904 GO:0004602 glutathione peroxidase activity 3/1183 23/18639 0.130434782608696 2.05509206512551 0.176462615090825 0.469732634969904 GO:0043274 phospholipase binding 3/1183 23/18639 0.130434782608696 2.05509206512551 0.176462615090825 0.469732634969904 GO:0044013 histone H2B acetyltransferase activity 3/1183 23/18639 0.130434782608696 2.05509206512551 0.176462615090825 0.469732634969904 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 3/1183 23/18639 0.130434782608696 2.05509206512551 0.176462615090825 0.469732634969904 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 6/1183 60/18639 0.1 1.57557058326289 0.179419570345074 0.473274866966083 GO:0005154 epidermal growth factor receptor binding 4/1183 35/18639 0.114285714285714 1.80065209515759 0.179491843197036 0.473274866966083 GO:0061631 ubiquitin conjugating enzyme activity 4/1183 35/18639 0.114285714285714 1.80065209515759 0.179491843197036 0.473274866966083 GO:0140566 histone reader activity 4/1183 35/18639 0.114285714285714 1.80065209515759 0.179491843197036 0.473274866966083 GO:0043539 protein serine/threonine kinase activator activity 7/1183 73/18639 0.0958904109589041 1.51082110723839 0.179894887265971 0.473274866966083 GO:0043138 3'-5' DNA helicase activity 5/1183 48/18639 0.104166666666667 1.64121935756551 0.186902377565102 0.490564282373671 GO:0055106 ubiquitin-protein transferase regulator activity 4/1183 36/18639 0.111111111111111 1.75063398140321 0.192523578852079 0.499779783653128 GO:0005315 phosphate transmembrane transporter activity 3/1183 24/18639 0.125 1.96946322907861 0.192788484248425 0.499779783653128 GO:0043998 histone H2A acetyltransferase activity 3/1183 24/18639 0.125 1.96946322907861 0.192788484248425 0.499779783653128 GO:0070300 phosphatidic acid binding 3/1183 24/18639 0.125 1.96946322907861 0.192788484248425 0.499779783653128 GO:0004197 cysteine-type endopeptidase activity 8/1183 88/18639 0.0909090909090909 1.43233689387536 0.19473305158189 0.499779783653128 GO:1901981 phosphatidylinositol phosphate binding 15/1183 185/18639 0.0810810810810811 1.27748966210505 0.197616876578561 0.499779783653128 GO:0004535 poly(A)-specific ribonuclease activity 2/1183 13/18639 0.153846153846154 2.42395474348137 0.197958955159232 0.499779783653128 GO:0015651 quaternary ammonium group transmembrane transporter activity 2/1183 13/18639 0.153846153846154 2.42395474348137 0.197958955159232 0.499779783653128 GO:0017154 semaphorin receptor activity 2/1183 13/18639 0.153846153846154 2.42395474348137 0.197958955159232 0.499779783653128 GO:0019855 calcium channel inhibitor activity 2/1183 13/18639 0.153846153846154 2.42395474348137 0.197958955159232 0.499779783653128 GO:0031432 titin binding 2/1183 13/18639 0.153846153846154 2.42395474348137 0.197958955159232 0.499779783653128 GO:0039706 co-receptor binding 2/1183 13/18639 0.153846153846154 2.42395474348137 0.197958955159232 0.499779783653128 GO:0070123 transforming growth factor beta receptor activity, type III 2/1183 13/18639 0.153846153846154 2.42395474348137 0.197958955159232 0.499779783653128 GO:0140333 glycerophospholipid flippase activity 2/1183 13/18639 0.153846153846154 2.42395474348137 0.197958955159232 0.499779783653128 GO:0140410 monoatomic cation:bicarbonate symporter activity 2/1183 13/18639 0.153846153846154 2.42395474348137 0.197958955159232 0.499779783653128 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 2/1183 13/18639 0.153846153846154 2.42395474348137 0.197958955159232 0.499779783653128 GO:0140852 histone ubiquitin ligase activity 2/1183 13/18639 0.153846153846154 2.42395474348137 0.197958955159232 0.499779783653128 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 19/1183 243/18639 0.0781893004115226 1.231927616543 0.203734609112646 0.513143965597708 GO:0022829 wide pore channel activity 4/1183 37/18639 0.108108108108108 1.7033195494734 0.205839024281905 0.513143965597708 GO:0017022 myosin binding 7/1183 76/18639 0.0921052631578947 1.45118343195266 0.206592501236532 0.513143965597708 GO:0051536 iron-sulfur cluster binding 7/1183 76/18639 0.0921052631578947 1.45118343195266 0.206592501236532 0.513143965597708 GO:0019210 kinase inhibitor activity 8/1183 90/18639 0.0888888888888889 1.40050718512257 0.21138353684791 0.513143965597708 GO:0004842 ubiquitin-protein transferase activity 33/1183 449/18639 0.0734966592427617 1.15799174270992 0.213307181221803 0.513143965597708 GO:0004676 3-phosphoinositide-dependent protein kinase activity 19/1183 245/18639 0.0775510204081633 1.22187106457122 0.213734031851976 0.513143965597708 GO:0004711 ribosomal protein S6 kinase activity 19/1183 245/18639 0.0775510204081633 1.22187106457122 0.213734031851976 0.513143965597708 GO:0035175 histone H3S10 kinase activity 19/1183 245/18639 0.0775510204081633 1.22187106457122 0.213734031851976 0.513143965597708 GO:0035979 histone H2AXS139 kinase activity 19/1183 245/18639 0.0775510204081633 1.22187106457122 0.213734031851976 0.513143965597708 GO:0044022 histone H3S28 kinase activity 19/1183 245/18639 0.0775510204081633 1.22187106457122 0.213734031851976 0.513143965597708 GO:0044023 histone H4S1 kinase activity 19/1183 245/18639 0.0775510204081633 1.22187106457122 0.213734031851976 0.513143965597708 GO:0044024 histone H2AS1 kinase activity 19/1183 245/18639 0.0775510204081633 1.22187106457122 0.213734031851976 0.513143965597708 GO:0044025 histone H2BS14 kinase activity 19/1183 245/18639 0.0775510204081633 1.22187106457122 0.213734031851976 0.513143965597708 GO:0072354 histone H3T3 kinase activity 19/1183 245/18639 0.0775510204081633 1.22187106457122 0.213734031851976 0.513143965597708 GO:0072371 histone H2AS121 kinase activity 19/1183 245/18639 0.0775510204081633 1.22187106457122 0.213734031851976 0.513143965597708 GO:0072518 Rho-dependent protein serine/threonine kinase activity 19/1183 245/18639 0.0775510204081633 1.22187106457122 0.213734031851976 0.513143965597708 GO:0140823 histone H2BS36 kinase activity 19/1183 245/18639 0.0775510204081633 1.22187106457122 0.213734031851976 0.513143965597708 GO:0140855 histone H3S57 kinase activity 19/1183 245/18639 0.0775510204081633 1.22187106457122 0.213734031851976 0.513143965597708 GO:0140995 histone H2A kinase activity 19/1183 245/18639 0.0775510204081633 1.22187106457122 0.213734031851976 0.513143965597708 GO:0140997 histone H4 kinase activity 19/1183 245/18639 0.0775510204081633 1.22187106457122 0.213734031851976 0.513143965597708 GO:0140998 histone H2B kinase activity 19/1183 245/18639 0.0775510204081633 1.22187106457122 0.213734031851976 0.513143965597708 GO:1990244 histone H2AT120 kinase activity 19/1183 245/18639 0.0775510204081633 1.22187106457122 0.213734031851976 0.513143965597708 GO:0003823 antigen binding 14/1183 174/18639 0.0804597701149425 1.26770046929198 0.215769246728432 0.514957025702729 GO:0004677 DNA-dependent protein kinase activity 19/1183 246/18639 0.0772357723577236 1.21690410902418 0.218817187479794 0.514957025702729 GO:0005126 cytokine receptor binding 21/1183 275/18639 0.0763636363636364 1.2031629908553 0.219351373922589 0.514957025702729 GO:0000146 microfilament motor activity 4/1183 38/18639 0.105263157894737 1.65849535080304 0.219410960272 0.514957025702729 GO:0005501 retinoid binding 4/1183 38/18639 0.105263157894737 1.65849535080304 0.219410960272 0.514957025702729 GO:0019840 isoprenoid binding 4/1183 38/18639 0.105263157894737 1.65849535080304 0.219410960272 0.514957025702729 GO:0042162 telomeric DNA binding 4/1183 38/18639 0.105263157894737 1.65849535080304 0.219410960272 0.514957025702729 GO:0043531 ADP binding 4/1183 38/18639 0.105263157894737 1.65849535080304 0.219410960272 0.514957025702729 GO:0005021 vascular endothelial growth factor receptor activity 5/1183 51/18639 0.0980392156862745 1.5446770424146 0.221143162867459 0.514957025702729 GO:0005347 ATP transmembrane transporter activity 2/1183 14/18639 0.142857142857143 2.25081511894699 0.221806534161478 0.514957025702729 GO:0005545 1-phosphatidylinositol binding 2/1183 14/18639 0.142857142857143 2.25081511894699 0.221806534161478 0.514957025702729 GO:0008191 metalloendopeptidase inhibitor activity 2/1183 14/18639 0.142857142857143 2.25081511894699 0.221806534161478 0.514957025702729 GO:0061665 SUMO ligase activity 2/1183 14/18639 0.142857142857143 2.25081511894699 0.221806534161478 0.514957025702729 GO:0098821 BMP receptor activity 2/1183 14/18639 0.142857142857143 2.25081511894699 0.221806534161478 0.514957025702729 GO:1901612 cardiolipin binding 2/1183 14/18639 0.142857142857143 2.25081511894699 0.221806534161478 0.514957025702729 GO:1990825 sequence-specific mRNA binding 2/1183 14/18639 0.142857142857143 2.25081511894699 0.221806534161478 0.514957025702729 GO:0035402 histone H3T11 kinase activity 19/1183 247/18639 0.0769230769230769 1.21197737174069 0.223954561281582 0.516163240590326 GO:0019199 transmembrane receptor protein kinase activity 7/1183 78/18639 0.0897435897435897 1.41397360036413 0.225170609775746 0.516163240590326 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 3/1183 26/18639 0.115384615384615 1.81796605761103 0.226451723669291 0.516163240590326 GO:0008143 poly(A) binding 3/1183 26/18639 0.115384615384615 1.81796605761103 0.226451723669291 0.516163240590326 GO:0030247 polysaccharide binding 3/1183 26/18639 0.115384615384615 1.81796605761103 0.226451723669291 0.516163240590326 GO:0030507 spectrin binding 3/1183 26/18639 0.115384615384615 1.81796605761103 0.226451723669291 0.516163240590326 GO:0043548 phosphatidylinositol 3-kinase binding 3/1183 26/18639 0.115384615384615 1.81796605761103 0.226451723669291 0.516163240590326 GO:0050681 nuclear androgen receptor binding 3/1183 26/18639 0.115384615384615 1.81796605761103 0.226451723669291 0.516163240590326 GO:0120014 phospholipid transfer activity 3/1183 26/18639 0.115384615384615 1.81796605761103 0.226451723669291 0.516163240590326 GO:0004679 AMP-activated protein kinase activity 19/1183 248/18639 0.0766129032258065 1.20709036620947 0.229145053477906 0.521247131749741 GO:0008013 beta-catenin binding 9/1183 106/18639 0.0849056603773585 1.33774860843076 0.230355752480011 0.52294471228325 GO:0000217 DNA secondary structure binding 4/1183 39/18639 0.102564102564103 1.61596982898758 0.233212230887463 0.527303156584906 GO:0016776 phosphotransferase activity, phosphate group as acceptor 4/1183 39/18639 0.102564102564103 1.61596982898758 0.233212230887463 0.527303156584906 GO:0008266 poly(U) RNA binding 3/1183 27/18639 0.111111111111111 1.75063398140321 0.243682750052634 0.539366827592867 GO:0015252 proton channel activity 3/1183 27/18639 0.111111111111111 1.75063398140321 0.243682750052634 0.539366827592867 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 3/1183 27/18639 0.111111111111111 1.75063398140321 0.243682750052634 0.539366827592867 GO:0004864 protein phosphatase inhibitor activity 5/1183 53/18639 0.0943396226415094 1.48638734270084 0.244947277392952 0.539366827592867 GO:0016860 intramolecular oxidoreductase activity 5/1183 53/18639 0.0943396226415094 1.48638734270084 0.244947277392952 0.539366827592867 GO:0017046 peptide hormone binding 5/1183 53/18639 0.0943396226415094 1.48638734270084 0.244947277392952 0.539366827592867 GO:0034212 protein N-acetyltransferase activity 5/1183 53/18639 0.0943396226415094 1.48638734270084 0.244947277392952 0.539366827592867 GO:0004865 protein serine/threonine phosphatase inhibitor activity 2/1183 15/18639 0.133333333333333 2.10076077768385 0.245860061693176 0.539366827592867 GO:0005041 low-density lipoprotein particle receptor activity 2/1183 15/18639 0.133333333333333 2.10076077768385 0.245860061693176 0.539366827592867 GO:0015929 hexosaminidase activity 2/1183 15/18639 0.133333333333333 2.10076077768385 0.245860061693176 0.539366827592867 GO:0016846 carbon-sulfur lyase activity 2/1183 15/18639 0.133333333333333 2.10076077768385 0.245860061693176 0.539366827592867 GO:0042809 nuclear vitamin D receptor binding 2/1183 15/18639 0.133333333333333 2.10076077768385 0.245860061693176 0.539366827592867 GO:0048531 beta-1,3-galactosyltransferase activity 2/1183 15/18639 0.133333333333333 2.10076077768385 0.245860061693176 0.539366827592867 GO:0050700 CARD domain binding 2/1183 15/18639 0.133333333333333 2.10076077768385 0.245860061693176 0.539366827592867 GO:0050780 dopamine receptor binding 2/1183 15/18639 0.133333333333333 2.10076077768385 0.245860061693176 0.539366827592867 GO:0016410 N-acyltransferase activity 8/1183 94/18639 0.0851063829787234 1.34091113469182 0.246211855579692 0.539366827592867 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 4/1183 40/18639 0.1 1.57557058326289 0.24721588303843 0.540514726798586 GO:0000510 H3-H4 histone complex chaperone activity 12/1183 151/18639 0.0794701986754967 1.2521090727917 0.25121447445566 0.545024081381645 GO:0140584 chromatin extrusion motor activity 12/1183 151/18639 0.0794701986754967 1.2521090727917 0.25121447445566 0.545024081381645 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 12/1183 151/18639 0.0794701986754967 1.2521090727917 0.25121447445566 0.545024081381645 GO:0140849 ATP-dependent H2AZ histone chaperone activity 12/1183 151/18639 0.0794701986754967 1.2521090727917 0.25121447445566 0.545024081381645 GO:0015399 primary active transmembrane transporter activity 13/1183 166/18639 0.0783132530120482 1.23388057725407 0.255929657655744 0.553140785416671 GO:0001664 G protein-coupled receptor binding 22/1183 297/18639 0.0740740740740741 1.16708932093547 0.255938143163486 0.553140785416671 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 5/1183 54/18639 0.0925925925925926 1.45886165116934 0.257092810050483 0.55351148014693 GO:0017069 snRNA binding 5/1183 54/18639 0.0925925925925926 1.45886165116934 0.257092810050483 0.55351148014693 GO:0015616 DNA translocase activity 12/1183 152/18639 0.0789473684210526 1.24387151310228 0.258302697895071 0.553997786342571 GO:0140674 ATP-dependent histone chaperone activity 12/1183 152/18639 0.0789473684210526 1.24387151310228 0.258302697895071 0.553997786342571 GO:0019789 SUMO transferase activity 3/1183 28/18639 0.107142857142857 1.68811133921024 0.261112416508018 0.556842009447024 GO:0051393 alpha-actinin binding 3/1183 28/18639 0.107142857142857 1.68811133921024 0.261112416508018 0.556842009447024 GO:0097718 disordered domain specific binding 3/1183 28/18639 0.107142857142857 1.68811133921024 0.261112416508018 0.556842009447024 GO:0016247 channel regulator activity 13/1183 168/18639 0.0773809523809524 1.21919152276295 0.269610698383575 0.562994675847819 GO:0004708 MAP kinase kinase activity 2/1183 16/18639 0.125 1.96946322907861 0.269997446676574 0.562994675847819 GO:0005024 transforming growth factor beta receptor activity 2/1183 16/18639 0.125 1.96946322907861 0.269997446676574 0.562994675847819 GO:0005159 insulin-like growth factor receptor binding 2/1183 16/18639 0.125 1.96946322907861 0.269997446676574 0.562994675847819 GO:0005521 lamin binding 2/1183 16/18639 0.125 1.96946322907861 0.269997446676574 0.562994675847819 GO:0015562 efflux transmembrane transporter activity 2/1183 16/18639 0.125 1.96946322907861 0.269997446676574 0.562994675847819 GO:0017070 U6 snRNA binding 2/1183 16/18639 0.125 1.96946322907861 0.269997446676574 0.562994675847819 GO:0031435 mitogen-activated protein kinase kinase kinase binding 2/1183 16/18639 0.125 1.96946322907861 0.269997446676574 0.562994675847819 GO:0055102 lipase inhibitor activity 2/1183 16/18639 0.125 1.96946322907861 0.269997446676574 0.562994675847819 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 2/1183 16/18639 0.125 1.96946322907861 0.269997446676574 0.562994675847819 GO:0140327 flippase activity 2/1183 16/18639 0.125 1.96946322907861 0.269997446676574 0.562994675847819 GO:0140328 floppase activity 2/1183 16/18639 0.125 1.96946322907861 0.269997446676574 0.562994675847819 GO:0002039 p53 binding 6/1183 69/18639 0.0869565217391304 1.37006137675034 0.272845826117104 0.566834686730367 GO:0008080 N-acetyltransferase activity 6/1183 69/18639 0.0869565217391304 1.37006137675034 0.272845826117104 0.566834686730367 GO:0008135 translation factor activity, RNA binding 7/1183 83/18639 0.0843373493975904 1.32879446781208 0.273878372467385 0.567931947326474 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 3/1183 29/18639 0.103448275862069 1.6299006033754 0.278692719404871 0.5757944991741 GO:0097472 cyclin-dependent protein kinase activity 3/1183 29/18639 0.103448275862069 1.6299006033754 0.278692719404871 0.5757944991741 GO:0004386 helicase activity 12/1183 155/18639 0.0774193548387097 1.21979658059063 0.279969014295537 0.577371996514238 GO:0005200 structural constituent of cytoskeleton 9/1183 112/18639 0.0803571428571429 1.26608350440768 0.280794560226879 0.578015858894818 GO:0141108 transporter regulator activity 13/1183 170/18639 0.0764705882352941 1.20484809308339 0.283531058099494 0.580249788877667 GO:0016782 transferase activity, transferring sulphur-containing groups 6/1183 70/18639 0.0857142857142857 1.35048907136819 0.283914739132146 0.580249788877667 GO:0004860 protein kinase inhibitor activity 7/1183 84/18639 0.0833333333333333 1.31297548605241 0.283941060099107 0.580249788877667 GO:0180051 translation factor activity 7/1183 84/18639 0.0833333333333333 1.31297548605241 0.283941060099107 0.580249788877667 GO:0004712 protein serine/threonine/tyrosine kinase activity 4/1183 43/18639 0.0930232558139535 1.46564705419804 0.290177190640769 0.591919414241859 GO:0004029 aldehyde dehydrogenase (NAD+) activity 2/1183 17/18639 0.117647058823529 1.85361245089752 0.294111242527892 0.592431590494467 GO:0004550 nucleoside diphosphate kinase activity 2/1183 17/18639 0.117647058823529 1.85361245089752 0.294111242527892 0.592431590494467 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 2/1183 17/18639 0.117647058823529 1.85361245089752 0.294111242527892 0.592431590494467 GO:0015278 intracellularly gated calcium channel activity 2/1183 17/18639 0.117647058823529 1.85361245089752 0.294111242527892 0.592431590494467 GO:0019198 transmembrane receptor protein phosphatase activity 2/1183 17/18639 0.117647058823529 1.85361245089752 0.294111242527892 0.592431590494467 GO:0051787 misfolded protein binding 2/1183 17/18639 0.117647058823529 1.85361245089752 0.294111242527892 0.592431590494467 GO:1990226 histone methyltransferase binding 2/1183 17/18639 0.117647058823529 1.85361245089752 0.294111242527892 0.592431590494467 GO:0140299 molecular sensor activity 6/1183 71/18639 0.0845070422535211 1.33146809853202 0.295079531951471 0.593320630316708 GO:0008187 poly-pyrimidine tract binding 3/1183 30/18639 0.1 1.57557058326289 0.296377985600409 0.594869183219359 GO:0140658 ATP-dependent chromatin remodeler activity 12/1183 158/18639 0.0759493670886076 1.19663588602245 0.302172646103286 0.605420639701601 GO:0140097 catalytic activity, acting on DNA 24/1183 336/18639 0.0714285714285714 1.12540755947349 0.303312115601901 0.606624231203803 GO:0022804 active transmembrane transporter activity 32/1183 457/18639 0.0700218818380744 1.1032441720878 0.306756868361989 0.609857688813873 GO:0017116 single-stranded DNA helicase activity 5/1183 58/18639 0.0862068965517241 1.35825050281284 0.306913136165335 0.609857688813873 GO:0140597 protein carrier chaperone 14/1183 188/18639 0.074468085106383 1.17329724285534 0.306933379300789 0.609857688813873 GO:0017124 SH3 domain binding 9/1183 115/18639 0.0782608695652174 1.23305523907531 0.307095301560805 0.609857688813873 GO:0005164 tumor necrosis factor receptor binding 3/1183 31/18639 0.0967741935483871 1.52474572573828 0.314124957372249 0.619447814362789 GO:0008327 methyl-CpG binding 3/1183 31/18639 0.0967741935483871 1.52474572573828 0.314124957372249 0.619447814362789 GO:0070273 phosphatidylinositol-4-phosphate binding 3/1183 31/18639 0.0967741935483871 1.52474572573828 0.314124957372249 0.619447814362789 GO:0072349 modified amino acid transmembrane transporter activity 3/1183 31/18639 0.0967741935483871 1.52474572573828 0.314124957372249 0.619447814362789 GO:0003689 DNA clamp loader activity 12/1183 160/18639 0.075 1.18167793744717 0.317231134873249 0.619703806567694 GO:0099106 ion channel regulator activity 12/1183 160/18639 0.075 1.18167793744717 0.317231134873249 0.619703806567694 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 2/1183 18/18639 0.111111111111111 1.75063398140321 0.318107282589811 0.619703806567694 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 2/1183 18/18639 0.111111111111111 1.75063398140321 0.318107282589811 0.619703806567694 GO:0008525 phosphatidylcholine transporter activity 2/1183 18/18639 0.111111111111111 1.75063398140321 0.318107282589811 0.619703806567694 GO:0017128 phospholipid scramblase activity 2/1183 18/18639 0.111111111111111 1.75063398140321 0.318107282589811 0.619703806567694 GO:0030228 lipoprotein particle receptor activity 2/1183 18/18639 0.111111111111111 1.75063398140321 0.318107282589811 0.619703806567694 GO:0015459 potassium channel regulator activity 5/1183 59/18639 0.0847457627118644 1.33522930784991 0.31959671290588 0.621530049623525 GO:0003678 DNA helicase activity 6/1183 74/18639 0.0810810810810811 1.27748966210505 0.329035649708076 0.638783002709126 GO:0015106 bicarbonate transmembrane transporter activity 3/1183 32/18639 0.09375 1.47709742180896 0.331892845387098 0.639683659452322 GO:0051059 NF-kappaB binding 3/1183 32/18639 0.09375 1.47709742180896 0.331892845387098 0.639683659452322 GO:0001098 basal transcription machinery binding 5/1183 60/18639 0.0833333333333333 1.31297548605241 0.332340089502317 0.639683659452322 GO:0001099 basal RNA polymerase II transcription machinery binding 5/1183 60/18639 0.0833333333333333 1.31297548605241 0.332340089502317 0.639683659452322 GO:0004714 transmembrane receptor protein tyrosine kinase activity 5/1183 60/18639 0.0833333333333333 1.31297548605241 0.332340089502317 0.639683659452322 GO:0030291 protein serine/threonine kinase inhibitor activity 4/1183 46/18639 0.0869565217391304 1.37006137675034 0.334032988942146 0.641844958274499 GO:0044183 protein folding chaperone 6/1183 75/18639 0.08 1.26045646661031 0.340470949726568 0.65251400285395 GO:0005346 purine ribonucleotide transmembrane transporter activity 2/1183 19/18639 0.105263157894737 1.65849535080304 0.341903429559352 0.65251400285395 GO:0008301 DNA binding, bending 2/1183 19/18639 0.105263157894737 1.65849535080304 0.341903429559352 0.65251400285395 GO:0046624 sphingolipid transporter activity 2/1183 19/18639 0.105263157894737 1.65849535080304 0.341903429559352 0.65251400285395 GO:0019905 syntaxin binding 5/1183 61/18639 0.0819672131147541 1.29145129775647 0.345128000747421 0.656567287120621 GO:0051087 protein-folding chaperone binding 10/1183 134/18639 0.0746268656716418 1.1757989427335 0.345193458237484 0.656567287120621 GO:0004175 endopeptidase activity 28/1183 405/18639 0.0691358024691358 1.08928336620644 0.346605618859042 0.65814152923319 GO:0140713 histone chaperone activity 12/1183 164/18639 0.0731707317073171 1.1528565243387 0.34784549320509 0.659383881058807 GO:0061749 forked DNA-dependent helicase activity 4/1183 47/18639 0.0851063829787234 1.34091113469182 0.348738871944726 0.659966335814724 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 3/1183 33/18639 0.0909090909090909 1.43233689387536 0.349643354159625 0.660567813395533 GO:0008094 ATP-dependent activity, acting on DNA 15/1183 210/18639 0.0714285714285714 1.12540755947349 0.355960541207213 0.671376163147942 GO:0000149 SNARE binding 8/1183 106/18639 0.0754716981132075 1.18910987416067 0.359241653160339 0.676431607790204 GO:0003724 RNA helicase activity 6/1183 77/18639 0.0779220779220779 1.22771733760745 0.36345082178372 0.678997379753751 GO:0009378 four-way junction helicase activity 4/1183 48/18639 0.0833333333333333 1.31297548605241 0.363451280524691 0.678997379753751 GO:0036121 double-stranded DNA helicase activity 4/1183 48/18639 0.0833333333333333 1.31297548605241 0.363451280524691 0.678997379753751 GO:0000339 RNA cap binding 2/1183 20/18639 0.1 1.57557058326289 0.365428429956282 0.678997379753751 GO:0001614 purinergic nucleotide receptor activity 2/1183 20/18639 0.1 1.57557058326289 0.365428429956282 0.678997379753751 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 2/1183 20/18639 0.1 1.57557058326289 0.365428429956282 0.678997379753751 GO:0016502 nucleotide receptor activity 2/1183 20/18639 0.1 1.57557058326289 0.365428429956282 0.678997379753751 GO:0042288 MHC class I protein binding 2/1183 20/18639 0.1 1.57557058326289 0.365428429956282 0.678997379753751 GO:0030332 cyclin binding 3/1183 34/18639 0.0882352941176471 1.39020933817314 0.367340683972955 0.681426046381462 GO:0005507 copper ion binding 5/1183 63/18639 0.0793650793650794 1.25045284385944 0.370778224337669 0.68667151415167 GO:0051213 dioxygenase activity 7/1183 93/18639 0.0752688172043011 1.18591334224089 0.377413979083783 0.686767897055234 GO:0005004 GPI-linked ephrin receptor activity 4/1183 49/18639 0.0816326530612245 1.28618006796971 0.378149286122775 0.686767897055234 GO:0005008 hepatocyte growth factor receptor activity 4/1183 49/18639 0.0816326530612245 1.28618006796971 0.378149286122775 0.686767897055234 GO:0005009 insulin receptor activity 4/1183 49/18639 0.0816326530612245 1.28618006796971 0.378149286122775 0.686767897055234 GO:0005011 macrophage colony-stimulating factor receptor activity 4/1183 49/18639 0.0816326530612245 1.28618006796971 0.378149286122775 0.686767897055234 GO:0005018 platelet-derived growth factor alpha-receptor activity 4/1183 49/18639 0.0816326530612245 1.28618006796971 0.378149286122775 0.686767897055234 GO:0005020 stem cell factor receptor activity 4/1183 49/18639 0.0816326530612245 1.28618006796971 0.378149286122775 0.686767897055234 GO:0008288 boss receptor activity 4/1183 49/18639 0.0816326530612245 1.28618006796971 0.378149286122775 0.686767897055234 GO:0035254 glutamate receptor binding 4/1183 49/18639 0.0816326530612245 1.28618006796971 0.378149286122775 0.686767897055234 GO:0036332 placental growth factor receptor activity 4/1183 49/18639 0.0816326530612245 1.28618006796971 0.378149286122775 0.686767897055234 GO:0038062 protein tyrosine kinase collagen receptor activity 4/1183 49/18639 0.0816326530612245 1.28618006796971 0.378149286122775 0.686767897055234 GO:0060175 brain-derived neurotrophic factor receptor activity 4/1183 49/18639 0.0816326530612245 1.28618006796971 0.378149286122775 0.686767897055234 GO:0000175 3'-5'-RNA exonuclease activity 3/1183 35/18639 0.0857142857142857 1.35048907136819 0.384951512795698 0.69799581869236 GO:0008186 ATP-dependent activity, acting on RNA 6/1183 79/18639 0.0759493670886076 1.19663588602245 0.386506019893511 0.69902091755216 GO:0001846 opsonin binding 2/1183 21/18639 0.0952380952380952 1.50054341263132 0.388620865353155 0.69902091755216 GO:0010314 phosphatidylinositol-5-phosphate binding 2/1183 21/18639 0.0952380952380952 1.50054341263132 0.388620865353155 0.69902091755216 GO:0035613 RNA stem-loop binding 2/1183 21/18639 0.0952380952380952 1.50054341263132 0.388620865353155 0.69902091755216 GO:0061891 calcium ion sensor activity 2/1183 21/18639 0.0952380952380952 1.50054341263132 0.388620865353155 0.69902091755216 GO:0005006 epidermal growth factor receptor activity 4/1183 50/18639 0.08 1.26045646661031 0.392812898862145 0.700962478793621 GO:0005007 fibroblast growth factor receptor activity 4/1183 50/18639 0.08 1.26045646661031 0.392812898862145 0.700962478793621 GO:0005017 platelet-derived growth factor receptor activity 4/1183 50/18639 0.08 1.26045646661031 0.392812898862145 0.700962478793621 GO:0005019 platelet-derived growth factor beta-receptor activity 4/1183 50/18639 0.08 1.26045646661031 0.392812898862145 0.700962478793621 GO:0032813 tumor necrosis factor receptor superfamily binding 4/1183 50/18639 0.08 1.26045646661031 0.392812898862145 0.700962478793621 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 3/1183 36/18639 0.0833333333333333 1.31297548605241 0.402444961336027 0.714752407672502 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 3/1183 36/18639 0.0833333333333333 1.31297548605241 0.402444961336027 0.714752407672502 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 3/1183 36/18639 0.0833333333333333 1.31297548605241 0.402444961336027 0.714752407672502 GO:0005010 insulin-like growth factor receptor activity 4/1183 51/18639 0.0784313725490196 1.23574163393168 0.407423089159565 0.721318236468035 GO:0005030 neurotrophin receptor activity 4/1183 51/18639 0.0784313725490196 1.23574163393168 0.407423089159565 0.721318236468035 GO:0016407 acetyltransferase activity 7/1183 96/18639 0.0729166666666667 1.14885355029586 0.409089931581951 0.721601471957445 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 2/1183 22/18639 0.0909090909090909 1.43233689387536 0.411428192714636 0.721601471957445 GO:0031683 G-protein beta/gamma-subunit complex binding 2/1183 22/18639 0.0909090909090909 1.43233689387536 0.411428192714636 0.721601471957445 GO:0034062 5'-3' RNA polymerase activity 2/1183 22/18639 0.0909090909090909 1.43233689387536 0.411428192714636 0.721601471957445 GO:0097747 RNA polymerase activity 2/1183 22/18639 0.0909090909090909 1.43233689387536 0.411428192714636 0.721601471957445 GO:0140784 metal ion sensor activity 2/1183 22/18639 0.0909090909090909 1.43233689387536 0.411428192714636 0.721601471957445 GO:0030246 carbohydrate binding 19/1183 280/18639 0.0678571428571429 1.06913718149982 0.415401381790484 0.727436945406042 GO:0016500 protein-hormone receptor activity 5/1183 67/18639 0.0746268656716418 1.1757989427335 0.42198555910263 0.737819471350251 GO:0000295 adenine nucleotide transmembrane transporter activity 2/1183 23/18639 0.0869565217391304 1.37006137675034 0.433805866774045 0.752333470931072 GO:0003887 DNA-directed DNA polymerase activity 2/1183 23/18639 0.0869565217391304 1.37006137675034 0.433805866774045 0.752333470931072 GO:0070577 lysine-acetylated histone binding 2/1183 23/18639 0.0869565217391304 1.37006137675034 0.433805866774045 0.752333470931072 GO:0099186 structural constituent of postsynapse 2/1183 23/18639 0.0869565217391304 1.37006137675034 0.433805866774045 0.752333470931072 GO:0005003 ephrin receptor activity 4/1183 53/18639 0.0754716981132075 1.18910987416067 0.436411967785549 0.752333470931072 GO:0005005 transmembrane-ephrin receptor activity 4/1183 53/18639 0.0754716981132075 1.18910987416067 0.436411967785549 0.752333470931072 GO:0005544 calcium-dependent phospholipid binding 4/1183 53/18639 0.0754716981132075 1.18910987416067 0.436411967785549 0.752333470931072 GO:0008146 sulfotransferase activity 4/1183 53/18639 0.0754716981132075 1.18910987416067 0.436411967785549 0.752333470931072 GO:0038064 collagen receptor activity 4/1183 53/18639 0.0754716981132075 1.18910987416067 0.436411967785549 0.752333470931072 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 3/1183 38/18639 0.0789473684210526 1.24387151310228 0.436968108338296 0.752333470931072 GO:0051287 NAD binding 4/1183 54/18639 0.0740740740740741 1.16708932093547 0.450757500404354 0.768268274138811 GO:0031072 heat shock protein binding 9/1183 131/18639 0.0687022900763359 1.08245307247069 0.452789377749735 0.768268274138811 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 3/1183 39/18639 0.0769230769230769 1.21197737174069 0.453947764792532 0.768268274138811 GO:0048027 mRNA 5'-UTR binding 2/1183 24/18639 0.0833333333333333 1.31297548605241 0.455716537912738 0.768268274138811 GO:0140033 acetylation-dependent protein binding 2/1183 24/18639 0.0833333333333333 1.31297548605241 0.455716537912738 0.768268274138811 GO:0015291 secondary active transmembrane transporter activity 19/1183 287/18639 0.0662020905923345 1.04306066487787 0.458679593568845 0.768268274138811 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 6/1183 86/18639 0.0697674418604651 1.09923529064853 0.466658777048236 0.768268274138811 GO:0004532 RNA exonuclease activity 3/1183 40/18639 0.075 1.18167793744717 0.470709809259081 0.768268274138811 GO:0061791 GTPase motor activity 3/1183 40/18639 0.075 1.18167793744717 0.470709809259081 0.768268274138811 GO:1990606 membrane scission GTPase motor activity 3/1183 40/18639 0.075 1.18167793744717 0.470709809259081 0.768268274138811 GO:0001848 complement binding 2/1183 25/18639 0.08 1.26045646661031 0.477129319505814 0.768268274138811 GO:0008483 transaminase activity 2/1183 25/18639 0.08 1.26045646661031 0.477129319505814 0.768268274138811 GO:0017025 TBP-class protein binding 2/1183 25/18639 0.08 1.26045646661031 0.477129319505814 0.768268274138811 GO:0017056 structural constituent of nuclear pore 2/1183 25/18639 0.08 1.26045646661031 0.477129319505814 0.768268274138811 GO:0019706 protein-cysteine S-palmitoyltransferase activity 2/1183 25/18639 0.08 1.26045646661031 0.477129319505814 0.768268274138811 GO:0019707 protein-cysteine S-acyltransferase activity 2/1183 25/18639 0.08 1.26045646661031 0.477129319505814 0.768268274138811 GO:0042974 nuclear retinoic acid receptor binding 2/1183 25/18639 0.08 1.26045646661031 0.477129319505814 0.768268274138811 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 2/1183 25/18639 0.08 1.26045646661031 0.477129319505814 0.768268274138811 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 12/1183 181/18639 0.0662983425414365 1.04457718227374 0.48090525649274 0.768268274138811 GO:0003680 minor groove of adenine-thymine-rich DNA binding 1/1183 10/18639 0.1 1.57557058326289 0.481020544642861 0.768268274138811 GO:0003796 lysozyme activity 1/1183 10/18639 0.1 1.57557058326289 0.481020544642861 0.768268274138811 GO:0004955 prostaglandin receptor activity 1/1183 10/18639 0.1 1.57557058326289 0.481020544642861 0.768268274138811 GO:0005131 growth hormone receptor binding 1/1183 10/18639 0.1 1.57557058326289 0.481020544642861 0.768268274138811 GO:0005381 iron ion transmembrane transporter activity 1/1183 10/18639 0.1 1.57557058326289 0.481020544642861 0.768268274138811 GO:0005528 FK506 binding 1/1183 10/18639 0.1 1.57557058326289 0.481020544642861 0.768268274138811 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 1/1183 10/18639 0.1 1.57557058326289 0.481020544642861 0.768268274138811 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 1/1183 10/18639 0.1 1.57557058326289 0.481020544642861 0.768268274138811 GO:0015658 branched-chain amino acid transmembrane transporter activity 1/1183 10/18639 0.1 1.57557058326289 0.481020544642861 0.768268274138811 GO:0015924 mannosyl-oligosaccharide mannosidase activity 1/1183 10/18639 0.1 1.57557058326289 0.481020544642861 0.768268274138811 GO:0016303 1-phosphatidylinositol-3-kinase activity 1/1183 10/18639 0.1 1.57557058326289 0.481020544642861 0.768268274138811 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 1/1183 10/18639 0.1 1.57557058326289 0.481020544642861 0.768268274138811 GO:0019531 oxalate transmembrane transporter activity 1/1183 10/18639 0.1 1.57557058326289 0.481020544642861 0.768268274138811 GO:0030957 Tat protein binding 1/1183 10/18639 0.1 1.57557058326289 0.481020544642861 0.768268274138811 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 1/1183 10/18639 0.1 1.57557058326289 0.481020544642861 0.768268274138811 GO:0031419 cobalamin binding 1/1183 10/18639 0.1 1.57557058326289 0.481020544642861 0.768268274138811 GO:0031434 mitogen-activated protein kinase kinase binding 1/1183 10/18639 0.1 1.57557058326289 0.481020544642861 0.768268274138811 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 1/1183 10/18639 0.1 1.57557058326289 0.481020544642861 0.768268274138811 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 1/1183 10/18639 0.1 1.57557058326289 0.481020544642861 0.768268274138811 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 1/1183 10/18639 0.1 1.57557058326289 0.481020544642861 0.768268274138811 GO:0042975 peroxisome proliferator activated receptor binding 1/1183 10/18639 0.1 1.57557058326289 0.481020544642861 0.768268274138811 GO:0043121 neurotrophin binding 1/1183 10/18639 0.1 1.57557058326289 0.481020544642861 0.768268274138811 GO:0043208 glycosphingolipid binding 1/1183 10/18639 0.1 1.57557058326289 0.481020544642861 0.768268274138811 GO:0047429 nucleoside triphosphate diphosphatase activity 1/1183 10/18639 0.1 1.57557058326289 0.481020544642861 0.768268274138811 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 1/1183 10/18639 0.1 1.57557058326289 0.481020544642861 0.768268274138811 GO:0050815 phosphoserine residue binding 1/1183 10/18639 0.1 1.57557058326289 0.481020544642861 0.768268274138811 GO:0140940 histone H2A methyltransferase activity 1/1183 10/18639 0.1 1.57557058326289 0.481020544642861 0.768268274138811 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 1/1183 10/18639 0.1 1.57557058326289 0.481020544642861 0.768268274138811 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 1/1183 10/18639 0.1 1.57557058326289 0.481020544642861 0.768268274138811 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 1/1183 10/18639 0.1 1.57557058326289 0.481020544642861 0.768268274138811 GO:1990259 histone H2AQ104 methyltransferase activity 1/1183 10/18639 0.1 1.57557058326289 0.481020544642861 0.768268274138811 GO:1990763 arrestin family protein binding 1/1183 10/18639 0.1 1.57557058326289 0.481020544642861 0.768268274138811 GO:0001727 lipid kinase activity 3/1183 41/18639 0.0731707317073171 1.1528565243387 0.487234639544966 0.772736804601061 GO:0042169 SH2 domain binding 3/1183 41/18639 0.0731707317073171 1.1528565243387 0.487234639544966 0.772736804601061 GO:0140318 protein transporter activity 3/1183 41/18639 0.0731707317073171 1.1528565243387 0.487234639544966 0.772736804601061 GO:0008017 microtubule binding 18/1183 276/18639 0.0652173913043478 1.02754603256275 0.487620438072239 0.772736804601061 GO:0005112 Notch binding 2/1183 26/18639 0.0769230769230769 1.21197737174069 0.498019119158857 0.772736804601061 GO:0008157 protein phosphatase 1 binding 2/1183 26/18639 0.0769230769230769 1.21197737174069 0.498019119158857 0.772736804601061 GO:0008198 ferrous iron binding 2/1183 26/18639 0.0769230769230769 1.21197737174069 0.498019119158857 0.772736804601061 GO:0015145 monosaccharide transmembrane transporter activity 2/1183 26/18639 0.0769230769230769 1.21197737174069 0.498019119158857 0.772736804601061 GO:0015216 purine nucleotide transmembrane transporter activity 2/1183 26/18639 0.0769230769230769 1.21197737174069 0.498019119158857 0.772736804601061 GO:0034237 protein kinase A regulatory subunit binding 2/1183 26/18639 0.0769230769230769 1.21197737174069 0.498019119158857 0.772736804601061 GO:0051139 metal cation:proton antiporter activity 2/1183 26/18639 0.0769230769230769 1.21197737174069 0.498019119158857 0.772736804601061 GO:0052742 phosphatidylinositol kinase activity 2/1183 26/18639 0.0769230769230769 1.21197737174069 0.498019119158857 0.772736804601061 GO:0070006 metalloaminopeptidase activity 2/1183 26/18639 0.0769230769230769 1.21197737174069 0.498019119158857 0.772736804601061 GO:0016859 cis-trans isomerase activity 3/1183 42/18639 0.0714285714285714 1.12540755947349 0.503504667547289 0.772736804601061 GO:0031492 nucleosomal DNA binding 3/1183 42/18639 0.0714285714285714 1.12540755947349 0.503504667547289 0.772736804601061 GO:0042056 chemoattractant activity 3/1183 42/18639 0.0714285714285714 1.12540755947349 0.503504667547289 0.772736804601061 GO:0051879 Hsp90 protein binding 3/1183 42/18639 0.0714285714285714 1.12540755947349 0.503504667547289 0.772736804601061 GO:0061135 endopeptidase regulator activity 12/1183 184/18639 0.0652173913043478 1.02754603256275 0.504136233001386 0.772736804601061 GO:0008408 3'-5' exonuclease activity 4/1183 58/18639 0.0689655172413793 1.08660040225027 0.506805875279895 0.772736804601061 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 1/1183 11/18639 0.0909090909090909 1.43233689387536 0.513977369791151 0.772736804601061 GO:0001851 complement component C3b binding 1/1183 11/18639 0.0909090909090909 1.43233689387536 0.513977369791151 0.772736804601061 GO:0002162 dystroglycan binding 1/1183 11/18639 0.0909090909090909 1.43233689387536 0.513977369791151 0.772736804601061 GO:0004016 adenylate cyclase activity 1/1183 11/18639 0.0909090909090909 1.43233689387536 0.513977369791151 0.772736804601061 GO:0004143 ATP-dependent diacylglycerol kinase activity 1/1183 11/18639 0.0909090909090909 1.43233689387536 0.513977369791151 0.772736804601061 GO:0004954 prostanoid receptor activity 1/1183 11/18639 0.0909090909090909 1.43233689387536 0.513977369791151 0.772736804601061 GO:0005114 type II transforming growth factor beta receptor binding 1/1183 11/18639 0.0909090909090909 1.43233689387536 0.513977369791151 0.772736804601061 GO:0005225 volume-sensitive anion channel activity 1/1183 11/18639 0.0909090909090909 1.43233689387536 0.513977369791151 0.772736804601061 GO:0005536 D-glucose binding 1/1183 11/18639 0.0909090909090909 1.43233689387536 0.513977369791151 0.772736804601061 GO:0008172 S-methyltransferase activity 1/1183 11/18639 0.0909090909090909 1.43233689387536 0.513977369791151 0.772736804601061 GO:0008271 secondary active sulfate transmembrane transporter activity 1/1183 11/18639 0.0909090909090909 1.43233689387536 0.513977369791151 0.772736804601061 GO:0008503 benzodiazepine receptor activity 1/1183 11/18639 0.0909090909090909 1.43233689387536 0.513977369791151 0.772736804601061 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 1/1183 11/18639 0.0909090909090909 1.43233689387536 0.513977369791151 0.772736804601061 GO:0019864 IgG binding 1/1183 11/18639 0.0909090909090909 1.43233689387536 0.513977369791151 0.772736804601061 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 1/1183 11/18639 0.0909090909090909 1.43233689387536 0.513977369791151 0.772736804601061 GO:0032794 GTPase activating protein binding 1/1183 11/18639 0.0909090909090909 1.43233689387536 0.513977369791151 0.772736804601061 GO:0034511 U3 snoRNA binding 1/1183 11/18639 0.0909090909090909 1.43233689387536 0.513977369791151 0.772736804601061 GO:0043522 leucine zipper domain binding 1/1183 11/18639 0.0909090909090909 1.43233689387536 0.513977369791151 0.772736804601061 GO:0045294 alpha-catenin binding 1/1183 11/18639 0.0909090909090909 1.43233689387536 0.513977369791151 0.772736804601061 GO:0050998 nitric-oxide synthase binding 1/1183 11/18639 0.0909090909090909 1.43233689387536 0.513977369791151 0.772736804601061 GO:0070697 activin receptor binding 1/1183 11/18639 0.0909090909090909 1.43233689387536 0.513977369791151 0.772736804601061 GO:0099528 G protein-coupled neurotransmitter receptor activity 1/1183 11/18639 0.0909090909090909 1.43233689387536 0.513977369791151 0.772736804601061 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 1/1183 11/18639 0.0909090909090909 1.43233689387536 0.513977369791151 0.772736804601061 GO:0180030 inositol phosphate kinase activity 1/1183 11/18639 0.0909090909090909 1.43233689387536 0.513977369791151 0.772736804601061 GO:0005506 iron ion binding 10/1183 154/18639 0.0649350649350649 1.02309778133954 0.517163017662813 0.772736804601061 GO:0004364 glutathione transferase activity 2/1183 27/18639 0.0740740740740741 1.16708932093547 0.518366028687355 0.772736804601061 GO:0005044 scavenger receptor activity 2/1183 27/18639 0.0740740740740741 1.16708932093547 0.518366028687355 0.772736804601061 GO:0005104 fibroblast growth factor receptor binding 2/1183 27/18639 0.0740740740740741 1.16708932093547 0.518366028687355 0.772736804601061 GO:0008320 protein transmembrane transporter activity 2/1183 27/18639 0.0740740740740741 1.16708932093547 0.518366028687355 0.772736804601061 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 2/1183 27/18639 0.0740740740740741 1.16708932093547 0.518366028687355 0.772736804601061 GO:0035255 ionotropic glutamate receptor binding 2/1183 27/18639 0.0740740740740741 1.16708932093547 0.518366028687355 0.772736804601061 GO:0005245 voltage-gated calcium channel activity 3/1183 43/18639 0.0697674418604651 1.09923529064853 0.519504228315278 0.772736804601061 GO:0008200 ion channel inhibitor activity 3/1183 43/18639 0.0697674418604651 1.09923529064853 0.519504228315278 0.772736804601061 GO:0016248 channel inhibitor activity 3/1183 44/18639 0.0681818181818182 1.07425267040652 0.535219487123123 0.780525708188846 GO:0019205 nucleobase-containing compound kinase activity 3/1183 44/18639 0.0681818181818182 1.07425267040652 0.535219487123123 0.780525708188846 GO:0045499 chemorepellent activity 2/1183 28/18639 0.0714285714285714 1.12540755947349 0.538154768085766 0.780525708188846 GO:0046625 sphingolipid binding 2/1183 28/18639 0.0714285714285714 1.12540755947349 0.538154768085766 0.780525708188846 GO:0050698 proteoglycan sulfotransferase activity 2/1183 28/18639 0.0714285714285714 1.12540755947349 0.538154768085766 0.780525708188846 GO:0051119 sugar transmembrane transporter activity 2/1183 28/18639 0.0714285714285714 1.12540755947349 0.538154768085766 0.780525708188846 GO:0004620 phospholipase activity 7/1183 109/18639 0.0642201834862385 1.01183431952663 0.542962512840557 0.780525708188846 GO:0000995 RNA polymerase III general transcription initiation factor activity 1/1183 12/18639 0.0833333333333333 1.31297548605241 0.544842989908022 0.780525708188846 GO:0004000 adenosine deaminase activity 1/1183 12/18639 0.0833333333333333 1.31297548605241 0.544842989908022 0.780525708188846 GO:0004126 cytidine deaminase activity 1/1183 12/18639 0.0833333333333333 1.31297548605241 0.544842989908022 0.780525708188846 GO:0004859 phospholipase inhibitor activity 1/1183 12/18639 0.0833333333333333 1.31297548605241 0.544842989908022 0.780525708188846 GO:0005049 nuclear export signal receptor activity 1/1183 12/18639 0.0833333333333333 1.31297548605241 0.544842989908022 0.780525708188846 GO:0005078 MAP-kinase scaffold activity 1/1183 12/18639 0.0833333333333333 1.31297548605241 0.544842989908022 0.780525708188846 GO:0005165 neurotrophin receptor binding 1/1183 12/18639 0.0833333333333333 1.31297548605241 0.544842989908022 0.780525708188846 GO:0005527 macrolide binding 1/1183 12/18639 0.0833333333333333 1.31297548605241 0.544842989908022 0.780525708188846 GO:0008179 adenylate cyclase binding 1/1183 12/18639 0.0833333333333333 1.31297548605241 0.544842989908022 0.780525708188846 GO:0015132 prostaglandin transmembrane transporter activity 1/1183 12/18639 0.0833333333333333 1.31297548605241 0.544842989908022 0.780525708188846 GO:0016208 AMP binding 1/1183 12/18639 0.0833333333333333 1.31297548605241 0.544842989908022 0.780525708188846 GO:0016273 arginine N-methyltransferase activity 1/1183 12/18639 0.0833333333333333 1.31297548605241 0.544842989908022 0.780525708188846 GO:0016274 protein-arginine N-methyltransferase activity 1/1183 12/18639 0.0833333333333333 1.31297548605241 0.544842989908022 0.780525708188846 GO:0016801 hydrolase activity, acting on ether bonds 1/1183 12/18639 0.0833333333333333 1.31297548605241 0.544842989908022 0.780525708188846 GO:0016803 ether hydrolase activity 1/1183 12/18639 0.0833333333333333 1.31297548605241 0.544842989908022 0.780525708188846 GO:0017166 vinculin binding 1/1183 12/18639 0.0833333333333333 1.31297548605241 0.544842989908022 0.780525708188846 GO:0034452 dynactin binding 1/1183 12/18639 0.0833333333333333 1.31297548605241 0.544842989908022 0.780525708188846 GO:0035251 UDP-glucosyltransferase activity 1/1183 12/18639 0.0833333333333333 1.31297548605241 0.544842989908022 0.780525708188846 GO:0036009 protein-glutamine N-methyltransferase activity 1/1183 12/18639 0.0833333333333333 1.31297548605241 0.544842989908022 0.780525708188846 GO:0045295 gamma-catenin binding 1/1183 12/18639 0.0833333333333333 1.31297548605241 0.544842989908022 0.780525708188846 GO:0070008 serine-type exopeptidase activity 1/1183 12/18639 0.0833333333333333 1.31297548605241 0.544842989908022 0.780525708188846 GO:0141221 histone deacetylase activity, hydrolytic mechanism 1/1183 12/18639 0.0833333333333333 1.31297548605241 0.544842989908022 0.780525708188846 GO:0008009 chemokine activity 3/1183 45/18639 0.0666666666666667 1.05038038884193 0.550638345513242 0.785828614762877 GO:0051539 4 iron, 4 sulfur cluster binding 3/1183 45/18639 0.0666666666666667 1.05038038884193 0.550638345513242 0.785828614762877 GO:0141110 transporter inhibitor activity 3/1183 45/18639 0.0666666666666667 1.05038038884193 0.550638345513242 0.785828614762877 GO:0004222 metalloendopeptidase activity 7/1183 110/18639 0.0636363636363636 1.00263582571275 0.552789764772372 0.787900348270495 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 2/1183 29/18639 0.0689655172413793 1.08660040225027 0.557374179099165 0.791429162251778 GO:0051861 glycolipid binding 2/1183 29/18639 0.0689655172413793 1.08660040225027 0.557374179099165 0.791429162251778 GO:0099604 ligand-gated calcium channel activity 2/1183 29/18639 0.0689655172413793 1.08660040225027 0.557374179099165 0.791429162251778 GO:1902936 phosphatidylinositol bisphosphate binding 7/1183 111/18639 0.0630630630630631 0.993603070526147 0.562524273102872 0.797735933896516 GO:0043022 ribosome binding 7/1183 112/18639 0.0625 0.984731614539307 0.572161868674641 0.797779676084945 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 1/1183 13/18639 0.0769230769230769 1.21197737174069 0.573749992803755 0.797779676084945 GO:0005172 vascular endothelial growth factor receptor binding 1/1183 13/18639 0.0769230769230769 1.21197737174069 0.573749992803755 0.797779676084945 GO:0008253 5'-nucleotidase activity 1/1183 13/18639 0.0769230769230769 1.21197737174069 0.573749992803755 0.797779676084945 GO:0019104 DNA N-glycosylase activity 1/1183 13/18639 0.0769230769230769 1.21197737174069 0.573749992803755 0.797779676084945 GO:0035325 Toll-like receptor binding 1/1183 13/18639 0.0769230769230769 1.21197737174069 0.573749992803755 0.797779676084945 GO:0035673 oligopeptide transmembrane transporter activity 1/1183 13/18639 0.0769230769230769 1.21197737174069 0.573749992803755 0.797779676084945 GO:0043560 insulin receptor substrate binding 1/1183 13/18639 0.0769230769230769 1.21197737174069 0.573749992803755 0.797779676084945 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 1/1183 13/18639 0.0769230769230769 1.21197737174069 0.573749992803755 0.797779676084945 GO:0046975 histone H3K36 methyltransferase activity 1/1183 13/18639 0.0769230769230769 1.21197737174069 0.573749992803755 0.797779676084945 GO:0061459 L-arginine transmembrane transporter activity 1/1183 13/18639 0.0769230769230769 1.21197737174069 0.573749992803755 0.797779676084945 GO:0071714 icosanoid transmembrane transporter activity 1/1183 13/18639 0.0769230769230769 1.21197737174069 0.573749992803755 0.797779676084945 GO:0089720 caspase binding 1/1183 13/18639 0.0769230769230769 1.21197737174069 0.573749992803755 0.797779676084945 GO:1901338 catecholamine binding 1/1183 13/18639 0.0769230769230769 1.21197737174069 0.573749992803755 0.797779676084945 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 2/1183 30/18639 0.0666666666666667 1.05038038884193 0.576016764349077 0.797779676084945 GO:0015215 nucleotide transmembrane transporter activity 2/1183 30/18639 0.0666666666666667 1.05038038884193 0.576016764349077 0.797779676084945 GO:0016769 transferase activity, transferring nitrogenous groups 2/1183 30/18639 0.0666666666666667 1.05038038884193 0.576016764349077 0.797779676084945 GO:0031210 phosphatidylcholine binding 2/1183 30/18639 0.0666666666666667 1.05038038884193 0.576016764349077 0.797779676084945 GO:0098918 structural constituent of synapse 2/1183 30/18639 0.0666666666666667 1.05038038884193 0.576016764349077 0.797779676084945 GO:0016298 lipase activity 8/1183 130/18639 0.0615384615384615 0.969581897392548 0.587626567635172 0.81186198178798 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 8/1183 130/18639 0.0615384615384615 0.969581897392548 0.587626567635172 0.81186198178798 GO:0017147 Wnt-protein binding 2/1183 31/18639 0.0645161290322581 1.01649715049219 0.594078268278513 0.813132463858411 GO:0047499 calcium-independent phospholipase A2 activity 2/1183 31/18639 0.0645161290322581 1.01649715049219 0.594078268278513 0.813132463858411 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 3/1183 48/18639 0.0625 0.984731614539307 0.595019604316207 0.813132463858411 GO:0032266 phosphatidylinositol-3-phosphate binding 3/1183 48/18639 0.0625 0.984731614539307 0.595019604316207 0.813132463858411 GO:0004065 arylsulfatase activity 1/1183 14/18639 0.0714285714285714 1.12540755947349 0.600822566545469 0.813132463858411 GO:0004705 JUN kinase activity 1/1183 14/18639 0.0714285714285714 1.12540755947349 0.600822566545469 0.813132463858411 GO:0008174 mRNA methyltransferase activity 1/1183 14/18639 0.0714285714285714 1.12540755947349 0.600822566545469 0.813132463858411 GO:0008195 phosphatidate phosphatase activity 1/1183 14/18639 0.0714285714285714 1.12540755947349 0.600822566545469 0.813132463858411 GO:0008331 high voltage-gated calcium channel activity 1/1183 14/18639 0.0714285714285714 1.12540755947349 0.600822566545469 0.813132463858411 GO:0008494 translation activator activity 1/1183 14/18639 0.0714285714285714 1.12540755947349 0.600822566545469 0.813132463858411 GO:0008559 ABC-type xenobiotic transporter activity 1/1183 14/18639 0.0714285714285714 1.12540755947349 0.600822566545469 0.813132463858411 GO:0015386 potassium:proton antiporter activity 1/1183 14/18639 0.0714285714285714 1.12540755947349 0.600822566545469 0.813132463858411 GO:0019763 immunoglobulin receptor activity 1/1183 14/18639 0.0714285714285714 1.12540755947349 0.600822566545469 0.813132463858411 GO:0032036 myosin heavy chain binding 1/1183 14/18639 0.0714285714285714 1.12540755947349 0.600822566545469 0.813132463858411 GO:0032454 histone H3K9 demethylase activity 1/1183 14/18639 0.0714285714285714 1.12540755947349 0.600822566545469 0.813132463858411 GO:0061783 peptidoglycan muralytic activity 1/1183 14/18639 0.0714285714285714 1.12540755947349 0.600822566545469 0.813132463858411 GO:0070742 C2H2 zinc finger domain binding 1/1183 14/18639 0.0714285714285714 1.12540755947349 0.600822566545469 0.813132463858411 GO:0022884 macromolecule transmembrane transporter activity 2/1183 32/18639 0.0625 0.984731614539307 0.611557296471274 0.820755084417943 GO:0030515 snoRNA binding 2/1183 32/18639 0.0625 0.984731614539307 0.611557296471274 0.820755084417943 GO:0042910 xenobiotic transmembrane transporter activity 2/1183 32/18639 0.0625 0.984731614539307 0.611557296471274 0.820755084417943 GO:0043425 bHLH transcription factor binding 2/1183 32/18639 0.0625 0.984731614539307 0.611557296471274 0.820755084417943 GO:0047498 calcium-dependent phospholipase A2 activity 2/1183 32/18639 0.0625 0.984731614539307 0.611557296471274 0.820755084417943 GO:0071813 lipoprotein particle binding 2/1183 32/18639 0.0625 0.984731614539307 0.611557296471274 0.820755084417943 GO:0071814 protein-lipid complex binding 2/1183 32/18639 0.0625 0.984731614539307 0.611557296471274 0.820755084417943 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 4/1183 67/18639 0.0597014925373134 0.940639154186801 0.622141841318749 0.820928418109128 GO:0015605 organophosphate ester transmembrane transporter activity 3/1183 50/18639 0.06 0.945342349957734 0.622972922115317 0.820928418109128 GO:0008237 metallopeptidase activity 11/1183 184/18639 0.0597826086956522 0.941917196515859 0.625178981091279 0.820928418109128 GO:0000774 adenyl-nucleotide exchange factor activity 1/1183 15/18639 0.0666666666666667 1.05038038884193 0.626177031177775 0.820928418109128 GO:0004129 cytochrome-c oxidase activity 1/1183 15/18639 0.0666666666666667 1.05038038884193 0.626177031177775 0.820928418109128 GO:0004559 alpha-mannosidase activity 1/1183 15/18639 0.0666666666666667 1.05038038884193 0.626177031177775 0.820928418109128 GO:0004953 icosanoid receptor activity 1/1183 15/18639 0.0666666666666667 1.05038038884193 0.626177031177775 0.820928418109128 GO:0005402 carbohydrate:monoatomic cation symporter activity 1/1183 15/18639 0.0666666666666667 1.05038038884193 0.626177031177775 0.820928418109128 GO:0005523 tropomyosin binding 1/1183 15/18639 0.0666666666666667 1.05038038884193 0.626177031177775 0.820928418109128 GO:0008252 nucleotidase activity 1/1183 15/18639 0.0666666666666667 1.05038038884193 0.626177031177775 0.820928418109128 GO:0015116 sulfate transmembrane transporter activity 1/1183 15/18639 0.0666666666666667 1.05038038884193 0.626177031177775 0.820928418109128 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 1/1183 15/18639 0.0666666666666667 1.05038038884193 0.626177031177775 0.820928418109128 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 1/1183 15/18639 0.0666666666666667 1.05038038884193 0.626177031177775 0.820928418109128 GO:0030553 cGMP binding 1/1183 15/18639 0.0666666666666667 1.05038038884193 0.626177031177775 0.820928418109128 GO:0031005 filamin binding 1/1183 15/18639 0.0666666666666667 1.05038038884193 0.626177031177775 0.820928418109128 GO:0033130 acetylcholine receptor binding 1/1183 15/18639 0.0666666666666667 1.05038038884193 0.626177031177775 0.820928418109128 GO:0047372 monoacylglycerol lipase activity 1/1183 15/18639 0.0666666666666667 1.05038038884193 0.626177031177775 0.820928418109128 GO:0141050 histone H3K deacetylase activity 1/1183 15/18639 0.0666666666666667 1.05038038884193 0.626177031177775 0.820928418109128 GO:0141051 histone H4K deacetylase activity 1/1183 15/18639 0.0666666666666667 1.05038038884193 0.626177031177775 0.820928418109128 GO:0019239 deaminase activity 2/1183 33/18639 0.0606060606060606 0.95489126258357 0.6284549701688 0.820928418109128 GO:0030296 protein tyrosine kinase activator activity 2/1183 33/18639 0.0606060606060606 0.95489126258357 0.6284549701688 0.820928418109128 GO:0071889 14-3-3 protein binding 2/1183 33/18639 0.0606060606060606 0.95489126258357 0.6284549701688 0.820928418109128 GO:0140416 transcription regulator inhibitor activity 2/1183 33/18639 0.0606060606060606 0.95489126258357 0.6284549701688 0.820928418109128 GO:0140223 general transcription initiation factor activity 4/1183 68/18639 0.0588235294117647 0.926806225448759 0.633857455605662 0.827026066062544 GO:0030414 peptidase inhibitor activity 10/1183 169/18639 0.0591715976331361 0.932290285954373 0.636421638358188 0.828481884157349 GO:0030544 Hsp70 protein binding 3/1183 51/18639 0.0588235294117647 0.926806225448759 0.636444786675051 0.828481884157349 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 2/1183 34/18639 0.0588235294117647 0.926806225448759 0.64477461305604 0.830661238648579 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 2/1183 34/18639 0.0588235294117647 0.926806225448759 0.64477461305604 0.830661238648579 GO:0090482 vitamin transmembrane transporter activity 2/1183 34/18639 0.0588235294117647 0.926806225448759 0.64477461305604 0.830661238648579 GO:0000062 fatty-acyl-CoA binding 1/1183 16/18639 0.0625 0.984731614539307 0.649922336811188 0.830661238648579 GO:0003688 DNA replication origin binding 1/1183 16/18639 0.0625 0.984731614539307 0.649922336811188 0.830661238648579 GO:0004707 MAP kinase activity 1/1183 16/18639 0.0625 0.984731614539307 0.649922336811188 0.830661238648579 GO:0005324 long-chain fatty acid transmembrane transporter activity 1/1183 16/18639 0.0625 0.984731614539307 0.649922336811188 0.830661238648579 GO:0008142 oxysterol binding 1/1183 16/18639 0.0625 0.984731614539307 0.649922336811188 0.830661238648579 GO:0008296 3'-5'-DNA exonuclease activity 1/1183 16/18639 0.0625 0.984731614539307 0.649922336811188 0.830661238648579 GO:0015385 sodium:proton antiporter activity 1/1183 16/18639 0.0625 0.984731614539307 0.649922336811188 0.830661238648579 GO:0015923 mannosidase activity 1/1183 16/18639 0.0625 0.984731614539307 0.649922336811188 0.830661238648579 GO:0016675 oxidoreductase activity, acting on a heme group of donors 1/1183 16/18639 0.0625 0.984731614539307 0.649922336811188 0.830661238648579 GO:0030275 LRR domain binding 1/1183 16/18639 0.0625 0.984731614539307 0.649922336811188 0.830661238648579 GO:0043023 ribosomal large subunit binding 1/1183 16/18639 0.0625 0.984731614539307 0.649922336811188 0.830661238648579 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 1/1183 16/18639 0.0625 0.984731614539307 0.649922336811188 0.830661238648579 GO:0097027 ubiquitin-protein transferase activator activity 1/1183 16/18639 0.0625 0.984731614539307 0.649922336811188 0.830661238648579 GO:0046982 protein heterodimerization activity 22/1183 369/18639 0.0596205962059621 0.939364575387089 0.651225657717946 0.831383322664861 GO:0016278 lysine N-methyltransferase activity 4/1183 70/18639 0.0571428571428571 0.900326047578795 0.656573777987414 0.835378318995127 GO:0043177 organic acid binding 11/1183 189/18639 0.0582010582010582 0.916998752163587 0.660279299402252 0.835378318995127 GO:0004623 phospholipase A2 activity 2/1183 35/18639 0.0571428571428571 0.900326047578795 0.660521467617273 0.835378318995127 GO:0005343 organic acid:sodium symporter activity 2/1183 35/18639 0.0571428571428571 0.900326047578795 0.660521467617273 0.835378318995127 GO:0034061 DNA polymerase activity 2/1183 35/18639 0.0571428571428571 0.900326047578795 0.660521467617273 0.835378318995127 GO:0016251 RNA polymerase II general transcription initiation factor activity 3/1183 53/18639 0.0566037735849057 0.891832405620504 0.662366263762765 0.835378318995127 GO:0140296 general transcription initiation factor binding 3/1183 53/18639 0.0566037735849057 0.891832405620504 0.662366263762765 0.835378318995127 GO:1901505 carbohydrate derivative transmembrane transporter activity 3/1183 53/18639 0.0566037735849057 0.891832405620504 0.662366263762765 0.835378318995127 GO:0140767 enzyme-substrate adaptor activity 8/1183 139/18639 0.0575539568345324 0.906803213388714 0.662996366690465 0.835378318995127 GO:0008484 sulfuric ester hydrolase activity 1/1183 17/18639 0.0588235294117647 0.926806225448759 0.672160530203894 0.835378318995127 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 1/1183 17/18639 0.0588235294117647 0.926806225448759 0.672160530203894 0.835378318995127 GO:0015347 sodium-independent organic anion transmembrane transporter activity 1/1183 17/18639 0.0588235294117647 0.926806225448759 0.672160530203894 0.835378318995127 GO:0016018 cyclosporin A binding 1/1183 17/18639 0.0588235294117647 0.926806225448759 0.672160530203894 0.835378318995127 GO:0030169 low-density lipoprotein particle binding 1/1183 17/18639 0.0588235294117647 0.926806225448759 0.672160530203894 0.835378318995127 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 1/1183 17/18639 0.0588235294117647 0.926806225448759 0.672160530203894 0.835378318995127 GO:0030548 acetylcholine receptor regulator activity 1/1183 17/18639 0.0588235294117647 0.926806225448759 0.672160530203894 0.835378318995127 GO:0032977 membrane insertase activity 1/1183 17/18639 0.0588235294117647 0.926806225448759 0.672160530203894 0.835378318995127 GO:0038191 neuropilin binding 1/1183 17/18639 0.0588235294117647 0.926806225448759 0.672160530203894 0.835378318995127 GO:0045125 bioactive lipid receptor activity 1/1183 17/18639 0.0588235294117647 0.926806225448759 0.672160530203894 0.835378318995127 GO:0045236 CXCR chemokine receptor binding 1/1183 17/18639 0.0588235294117647 0.926806225448759 0.672160530203894 0.835378318995127 GO:0046965 nuclear retinoid X receptor binding 1/1183 17/18639 0.0588235294117647 0.926806225448759 0.672160530203894 0.835378318995127 GO:0070402 NADPH binding 1/1183 17/18639 0.0588235294117647 0.926806225448759 0.672160530203894 0.835378318995127 GO:0070492 oligosaccharide binding 1/1183 17/18639 0.0588235294117647 0.926806225448759 0.672160530203894 0.835378318995127 GO:1901567 fatty acid derivative binding 1/1183 17/18639 0.0588235294117647 0.926806225448759 0.672160530203894 0.835378318995127 GO:0016409 palmitoyltransferase activity 2/1183 36/18639 0.0555555555555556 0.875316990701606 0.675702438574993 0.838854405551755 GO:0030280 structural constituent of skin epidermis 2/1183 37/18639 0.0540540540540541 0.851659774736698 0.690325861121148 0.852790795626899 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 5/1183 91/18639 0.0549450549450549 0.865698122671918 0.692800882735453 0.852790795626899 GO:0004706 JUN kinase kinase kinase activity 1/1183 18/18639 0.0555555555555556 0.875316990701606 0.692987191828252 0.852790795626899 GO:0017075 syntaxin-1 binding 1/1183 18/18639 0.0555555555555556 0.875316990701606 0.692987191828252 0.852790795626899 GO:0032393 MHC class I receptor activity 1/1183 18/18639 0.0555555555555556 0.875316990701606 0.692987191828252 0.852790795626899 GO:0034185 apolipoprotein binding 1/1183 18/18639 0.0555555555555556 0.875316990701606 0.692987191828252 0.852790795626899 GO:0098641 cadherin binding involved in cell-cell adhesion 1/1183 18/18639 0.0555555555555556 0.875316990701606 0.692987191828252 0.852790795626899 GO:0099602 neurotransmitter receptor regulator activity 1/1183 18/18639 0.0555555555555556 0.875316990701606 0.692987191828252 0.852790795626899 GO:0031491 nucleosome binding 4/1183 74/18639 0.0540540540540541 0.851659774736698 0.699089900483897 0.858424457955145 GO:0035064 methylated histone binding 4/1183 74/18639 0.0540540540540541 0.851659774736698 0.699089900483897 0.858424457955145 GO:0004866 endopeptidase inhibitor activity 9/1183 161/18639 0.0559006211180124 0.880753742196647 0.700122621397001 0.858756069382378 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 13/1183 229/18639 0.0567685589519651 0.894428715389414 0.701000988349639 0.858897837738513 GO:0005109 frizzled binding 2/1183 38/18639 0.0526315789473684 0.829247675401522 0.704401291831307 0.861724831142726 GO:0005229 intracellularly calcium-gated chloride channel activity 1/1183 19/18639 0.0526315789473684 0.829247675401522 0.712491845287636 0.861724831142726 GO:0015245 fatty acid transmembrane transporter activity 1/1183 19/18639 0.0526315789473684 0.829247675401522 0.712491845287636 0.861724831142726 GO:0022840 leak channel activity 1/1183 19/18639 0.0526315789473684 0.829247675401522 0.712491845287636 0.861724831142726 GO:0022842 narrow pore channel activity 1/1183 19/18639 0.0526315789473684 0.829247675401522 0.712491845287636 0.861724831142726 GO:0034987 immunoglobulin receptor binding 1/1183 19/18639 0.0526315789473684 0.829247675401522 0.712491845287636 0.861724831142726 GO:0042577 lipid phosphatase activity 1/1183 19/18639 0.0526315789473684 0.829247675401522 0.712491845287636 0.861724831142726 GO:0046527 glucosyltransferase activity 1/1183 19/18639 0.0526315789473684 0.829247675401522 0.712491845287636 0.861724831142726 GO:0050145 nucleoside monophosphate kinase activity 1/1183 19/18639 0.0526315789473684 0.829247675401522 0.712491845287636 0.861724831142726 GO:0097001 ceramide binding 1/1183 19/18639 0.0526315789473684 0.829247675401522 0.712491845287636 0.861724831142726 GO:0120227 acyl-CoA binding 1/1183 19/18639 0.0526315789473684 0.829247675401522 0.712491845287636 0.861724831142726 GO:0141147 intracellularly calcium-gated channel activity 1/1183 19/18639 0.0526315789473684 0.829247675401522 0.712491845287636 0.861724831142726 GO:0015293 symporter activity 8/1183 146/18639 0.0547945205479452 0.863326346993365 0.715547537900821 0.864491982485326 GO:0140034 methylation-dependent protein binding 4/1183 76/18639 0.0526315789473684 0.829247675401522 0.718876252154033 0.867582700884717 GO:0015103 inorganic anion transmembrane transporter activity 9/1183 165/18639 0.0545454545454545 0.859402136325213 0.727153517282023 0.868197548766277 GO:0004867 serine-type endopeptidase inhibitor activity 5/1183 95/18639 0.0526315789473684 0.829247675401522 0.7283768241474 0.868197548766277 GO:0008276 protein methyltransferase activity 5/1183 95/18639 0.0526315789473684 0.829247675401522 0.7283768241474 0.868197548766277 GO:0015095 magnesium ion transmembrane transporter activity 1/1183 20/18639 0.05 0.787785291631446 0.730758340831391 0.868197548766277 GO:0016505 peptidase activator activity involved in apoptotic process 1/1183 20/18639 0.05 0.787785291631446 0.730758340831391 0.868197548766277 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 1/1183 20/18639 0.05 0.787785291631446 0.730758340831391 0.868197548766277 GO:0030742 GTP-dependent protein binding 1/1183 20/18639 0.05 0.787785291631446 0.730758340831391 0.868197548766277 GO:0043024 ribosomal small subunit binding 1/1183 20/18639 0.05 0.787785291631446 0.730758340831391 0.868197548766277 GO:0140939 histone H4 methyltransferase activity 1/1183 20/18639 0.05 0.787785291631446 0.730758340831391 0.868197548766277 GO:0004177 aminopeptidase activity 2/1183 40/18639 0.05 0.787785291631446 0.730951399849405 0.868197548766277 GO:0015144 carbohydrate transmembrane transporter activity 2/1183 40/18639 0.05 0.787785291631446 0.730951399849405 0.868197548766277 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 2/1183 40/18639 0.05 0.787785291631446 0.730951399849405 0.868197548766277 GO:0030331 nuclear estrogen receptor binding 2/1183 40/18639 0.05 0.787785291631446 0.730951399849405 0.868197548766277 GO:0050997 quaternary ammonium group binding 2/1183 40/18639 0.05 0.787785291631446 0.730951399849405 0.868197548766277 GO:0140662 ATP-dependent protein folding chaperone 2/1183 40/18639 0.05 0.787785291631446 0.730951399849405 0.868197548766277 GO:0036002 pre-mRNA binding 3/1183 59/18639 0.0508474576271186 0.801137584709945 0.731955284132436 0.868473814471152 GO:0008509 monoatomic anion transmembrane transporter activity 8/1183 149/18639 0.0536912751677852 0.845943937322358 0.736326759565462 0.872740980284959 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 3/1183 60/18639 0.05 0.787785291631446 0.742381591504702 0.874450915519804 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 3/1183 60/18639 0.05 0.787785291631446 0.742381591504702 0.874450915519804 GO:0008227 G protein-coupled amine receptor activity 2/1183 41/18639 0.0487804878048781 0.7685710162258 0.743449695249633 0.874450915519804 GO:0016877 ligase activity, forming carbon-sulfur bonds 2/1183 41/18639 0.0487804878048781 0.7685710162258 0.743449695249633 0.874450915519804 GO:0015370 solute:sodium symporter activity 4/1183 79/18639 0.0506329113924051 0.797757257348299 0.746725534181018 0.874450915519804 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 1/1183 21/18639 0.0476190476190476 0.750271706315662 0.747865214605303 0.874450915519804 GO:0005123 death receptor binding 1/1183 21/18639 0.0476190476190476 0.750271706315662 0.747865214605303 0.874450915519804 GO:0008373 sialyltransferase activity 1/1183 21/18639 0.0476190476190476 0.750271706315662 0.747865214605303 0.874450915519804 GO:0009975 cyclase activity 1/1183 21/18639 0.0476190476190476 0.750271706315662 0.747865214605303 0.874450915519804 GO:0015174 basic amino acid transmembrane transporter activity 1/1183 21/18639 0.0476190476190476 0.750271706315662 0.747865214605303 0.874450915519804 GO:0019200 carbohydrate kinase activity 1/1183 21/18639 0.0476190476190476 0.750271706315662 0.747865214605303 0.874450915519804 GO:0036122 BMP binding 1/1183 21/18639 0.0476190476190476 0.750271706315662 0.747865214605303 0.874450915519804 GO:1904047 S-adenosyl-L-methionine binding 1/1183 21/18639 0.0476190476190476 0.750271706315662 0.747865214605303 0.874450915519804 GO:0008170 N-methyltransferase activity 5/1183 98/18639 0.0510204081632653 0.803862542481067 0.75303980955266 0.879587993315659 GO:0019894 kinesin binding 2/1183 42/18639 0.0476190476190476 0.750271706315662 0.75544694663475 0.880915661778467 GO:0031406 carboxylic acid binding 10/1183 187/18639 0.053475935828877 0.842551114044327 0.755741145007104 0.880915661778467 GO:0003774 cytoskeletal motor activity 8/1183 153/18639 0.0522875816993464 0.823827755954453 0.762376028842193 0.884913234920923 GO:0004407 histone deacetylase activity 1/1183 22/18639 0.0454545454545455 0.716168446937678 0.763886025171525 0.884913234920923 GO:0005243 gap junction channel activity 1/1183 22/18639 0.0454545454545455 0.716168446937678 0.763886025171525 0.884913234920923 GO:0008970 phospholipase A1 activity 1/1183 22/18639 0.0454545454545455 0.716168446937678 0.763886025171525 0.884913234920923 GO:0030021 extracellular matrix structural constituent conferring compression resistance 1/1183 22/18639 0.0454545454545455 0.716168446937678 0.763886025171525 0.884913234920923 GO:0033558 protein lysine deacetylase activity 1/1183 22/18639 0.0454545454545455 0.716168446937678 0.763886025171525 0.884913234920923 GO:0005283 amino acid:sodium symporter activity 1/1183 23/18639 0.0434782608695652 0.68503068837517 0.778889668735047 0.894938414423328 GO:0016849 phosphorus-oxygen lyase activity 1/1183 23/18639 0.0434782608695652 0.68503068837517 0.778889668735047 0.894938414423328 GO:0004536 DNA nuclease activity 3/1183 64/18639 0.046875 0.73854871090448 0.780879615937353 0.894938414423328 GO:0003730 mRNA 3'-UTR binding 14/1183 262/18639 0.0534351145038168 0.84190794525498 0.783970196815774 0.894938414423328 GO:0016887 ATP hydrolysis activity 23/1183 417/18639 0.0551558752997602 0.869019746164184 0.787013049581653 0.894938414423328 GO:0051082 unfolded protein binding 6/1183 121/18639 0.0495867768595041 0.781274669386558 0.787530103830643 0.894938414423328 GO:0004527 exonuclease activity 4/1183 84/18639 0.0476190476190476 0.750271706315662 0.788373930041167 0.894938414423328 GO:0046915 transition metal ion transmembrane transporter activity 2/1183 45/18639 0.0444444444444444 0.700253592561285 0.788565998472871 0.894938414423328 GO:0019843 rRNA binding 3/1183 65/18639 0.0461538461538462 0.727186423044411 0.789728020136376 0.894938414423328 GO:0005253 monoatomic anion channel activity 5/1183 103/18639 0.0485436893203883 0.764840088962568 0.790361658772967 0.894938414423328 GO:0004806 triacylglycerol lipase activity 1/1183 24/18639 0.0416666666666667 0.656487743026205 0.792940674422973 0.894938414423328 GO:0005540 hyaluronic acid binding 1/1183 24/18639 0.0416666666666667 0.656487743026205 0.792940674422973 0.894938414423328 GO:0015149 hexose transmembrane transporter activity 1/1183 24/18639 0.0416666666666667 0.656487743026205 0.792940674422973 0.894938414423328 GO:0015295 solute:proton symporter activity 1/1183 24/18639 0.0416666666666667 0.656487743026205 0.792940674422973 0.894938414423328 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 1/1183 24/18639 0.0416666666666667 0.656487743026205 0.792940674422973 0.894938414423328 GO:0030215 semaphorin receptor binding 1/1183 24/18639 0.0416666666666667 0.656487743026205 0.792940674422973 0.894938414423328 GO:0042625 ATPase-coupled ion transmembrane transporter activity 1/1183 24/18639 0.0416666666666667 0.656487743026205 0.792940674422973 0.894938414423328 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 1/1183 24/18639 0.0416666666666667 0.656487743026205 0.792940674422973 0.894938414423328 GO:0046961 proton-transporting ATPase activity, rotational mechanism 1/1183 24/18639 0.0416666666666667 0.656487743026205 0.792940674422973 0.894938414423328 GO:0050431 transforming growth factor beta binding 1/1183 24/18639 0.0416666666666667 0.656487743026205 0.792940674422973 0.894938414423328 GO:0055056 D-glucose transmembrane transporter activity 1/1183 24/18639 0.0416666666666667 0.656487743026205 0.792940674422973 0.894938414423328 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 1/1183 24/18639 0.0416666666666667 0.656487743026205 0.792940674422973 0.894938414423328 GO:0070840 dynein complex binding 1/1183 24/18639 0.0416666666666667 0.656487743026205 0.792940674422973 0.894938414423328 GO:0140612 DNA damage sensor activity 1/1183 24/18639 0.0416666666666667 0.656487743026205 0.792940674422973 0.894938414423328 GO:0008236 serine-type peptidase activity 10/1183 194/18639 0.0515463917525773 0.812149785187057 0.793998002861666 0.894938414423328 GO:0008528 G protein-coupled peptide receptor activity 6/1183 122/18639 0.0491803278688525 0.774870778653881 0.793999534643788 0.894938414423328 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 6/1183 122/18639 0.0491803278688525 0.774870778653881 0.793999534643788 0.894938414423328 GO:0008235 metalloexopeptidase activity 3/1183 66/18639 0.0454545454545455 0.716168446937678 0.798277344308121 0.898430993441876 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 2/1183 46/18639 0.0434782608695652 0.68503068837517 0.798693982624616 0.898430993441876 GO:0000030 mannosyltransferase activity 1/1183 25/18639 0.04 0.630228233305156 0.806099480877855 0.903638747968261 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 1/1183 25/18639 0.04 0.630228233305156 0.806099480877855 0.903638747968261 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 1/1183 25/18639 0.04 0.630228233305156 0.806099480877855 0.903638747968261 GO:0042054 histone methyltransferase activity 3/1183 67/18639 0.0447761194029851 0.7054793656401 0.806533696010748 0.903638747968261 GO:0099095 ligand-gated monoatomic anion channel activity 2/1183 47/18639 0.0425531914893617 0.670455567345911 0.808389422559966 0.903919056407668 GO:0140938 histone H3 methyltransferase activity 2/1183 47/18639 0.0425531914893617 0.670455567345911 0.808389422559966 0.903919056407668 GO:0016853 isomerase activity 9/1183 180/18639 0.05 0.787785291631446 0.813615075659742 0.907956890633633 GO:0017171 serine hydrolase activity 10/1183 198/18639 0.0505050505050505 0.795742718819642 0.813797331227071 0.907956890633633 GO:0008514 organic anion transmembrane transporter activity 14/1183 269/18639 0.0520446096654275 0.819999560062471 0.814419591065692 0.907956890633633 GO:0005125 cytokine activity 12/1183 234/18639 0.0512820512820513 0.80798491449379 0.81555920611547 0.908328057454025 GO:0004529 DNA exonuclease activity 1/1183 26/18639 0.0384615384615385 0.605988685870343 0.818422695346615 0.908820468402652 GO:0005227 calcium-activated cation channel activity 1/1183 26/18639 0.0384615384615385 0.605988685870343 0.818422695346615 0.908820468402652 GO:0019865 immunoglobulin binding 1/1183 26/18639 0.0384615384615385 0.605988685870343 0.818422695346615 0.908820468402652 GO:0016279 protein-lysine N-methyltransferase activity 3/1183 69/18639 0.0434782608695652 0.68503068837517 0.822192808861159 0.911677614301419 GO:0005261 monoatomic cation channel activity 18/1183 341/18639 0.0527859237536657 0.831679486766335 0.822614969920285 0.911677614301419 GO:0015081 sodium ion transmembrane transporter activity 8/1183 164/18639 0.0487804878048781 0.7685710162258 0.824359421803551 0.912712594838543 GO:0060590 ATPase regulator activity 2/1183 49/18639 0.0408163265306122 0.643090033984853 0.826538841411564 0.914226655628115 GO:0001653 peptide receptor activity 6/1183 128/18639 0.046875 0.73854871090448 0.829670673398948 0.915317058525798 GO:0001671 ATPase activator activity 1/1183 27/18639 0.037037037037037 0.583544660467737 0.829963336371971 0.915317058525798 GO:0004683 calcium/calmodulin-dependent protein kinase activity 1/1183 27/18639 0.037037037037037 0.583544660467737 0.829963336371971 0.915317058525798 GO:0016798 hydrolase activity, acting on glycosyl bonds 6/1183 130/18639 0.0461538461538462 0.727186423044411 0.840403181527106 0.924519741039892 GO:0051959 dynein light intermediate chain binding 1/1183 28/18639 0.0357142857142857 0.562703779736747 0.840771061123312 0.924519741039892 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 1/1183 28/18639 0.0357142857142857 0.562703779736747 0.840771061123312 0.924519741039892 GO:0016597 amino acid binding 2/1183 51/18639 0.0392156862745098 0.61787081696584 0.843125896268248 0.925616582137641 GO:0052689 carboxylic ester hydrolase activity 4/1183 92/18639 0.0434782608695652 0.68503068837517 0.843412622800373 0.925616582137641 GO:0005179 hormone activity 6/1183 132/18639 0.0454545454545455 0.716168446937678 0.850582113063332 0.931102835771726 GO:0004181 metallocarboxypeptidase activity 1/1183 29/18639 0.0344827586206897 0.543300201125135 0.85089237833846 0.931102835771726 GO:0005416 amino acid:monoatomic cation symporter activity 1/1183 29/18639 0.0344827586206897 0.543300201125135 0.85089237833846 0.931102835771726 GO:0001965 G-protein alpha-subunit binding 1/1183 30/18639 0.0333333333333333 0.525190194420964 0.86037084778637 0.938737959890943 GO:0022839 monoatomic ion-gated channel activity 1/1183 30/18639 0.0333333333333333 0.525190194420964 0.86037084778637 0.938737959890943 GO:0033612 receptor serine/threonine kinase binding 1/1183 30/18639 0.0333333333333333 0.525190194420964 0.86037084778637 0.938737959890943 GO:0050661 NADP binding 2/1183 54/18639 0.037037037037037 0.583544660467737 0.865315721612578 0.943040800278198 GO:0042393 histone binding 12/1183 247/18639 0.048582995951417 0.765459392678328 0.866139960020389 0.943040800278198 GO:0015294 solute:monoatomic cation symporter activity 5/1183 116/18639 0.0431034482758621 0.679125251406419 0.866827023346301 0.943040800278198 GO:0098631 cell adhesion mediator activity 3/1183 76/18639 0.0394736842105263 0.621935756551141 0.868733152204776 0.943849973730293 GO:0005310 dicarboxylic acid transmembrane transporter activity 1/1183 31/18639 0.032258064516129 0.508248575246094 0.869247267103299 0.943849973730293 GO:0098632 cell-cell adhesion mediator activity 2/1183 55/18639 0.0363636363636364 0.572934757550142 0.87204765653887 0.945978479058543 GO:0031369 translation initiation factor binding 1/1183 32/18639 0.03125 0.492365807269653 0.877559846801106 0.95104175890091 GO:0170055 lipid transmembrane transporter activity 2/1183 56/18639 0.0357142857142857 0.562703779736747 0.878468524842274 0.951111114396539 GO:0015932 nucleobase-containing compound transmembrane transporter activity 2/1183 57/18639 0.0350877192982456 0.552831783601014 0.884590653290158 0.956503824189875 GO:0016835 carbon-oxygen lyase activity 3/1183 79/18639 0.0379746835443038 0.598317943011224 0.885148299117096 0.956503824189875 GO:0004540 RNA nuclease activity 5/1183 121/18639 0.0413223140495868 0.651062224488798 0.889228677512999 0.958008603164456 GO:0015108 chloride transmembrane transporter activity 5/1183 121/18639 0.0413223140495868 0.651062224488798 0.889228677512999 0.958008603164456 GO:0000049 tRNA binding 3/1183 80/18639 0.0375 0.590838968723584 0.890198513909253 0.958008603164456 GO:0015020 glucuronosyltransferase activity 1/1183 34/18639 0.0294117647058824 0.46340311272438 0.892634366957679 0.958008603164456 GO:0016831 carboxy-lyase activity 1/1183 34/18639 0.0294117647058824 0.46340311272438 0.892634366957679 0.958008603164456 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 1/1183 34/18639 0.0294117647058824 0.46340311272438 0.892634366957679 0.958008603164456 GO:0051427 hormone receptor binding 1/1183 34/18639 0.0294117647058824 0.46340311272438 0.892634366957679 0.958008603164456 GO:0016829 lyase activity 9/1183 200/18639 0.045 0.709006762468301 0.894429774915234 0.958008603164456 GO:0008238 exopeptidase activity 4/1183 102/18639 0.0392156862745098 0.61787081696584 0.894781622484213 0.958008603164456 GO:0015101 organic cation transmembrane transporter activity 3/1183 81/18639 0.037037037037037 0.583544660467737 0.895048890345477 0.958008603164456 GO:0005254 chloride channel activity 3/1183 83/18639 0.036144578313253 0.569483343348033 0.904175694286735 0.962758945676427 GO:0004190 aspartic-type endopeptidase activity 1/1183 36/18639 0.0277777777777778 0.437658495350803 0.905854324891515 0.962758945676427 GO:0004869 cysteine-type endopeptidase inhibitor activity 1/1183 36/18639 0.0277777777777778 0.437658495350803 0.905854324891515 0.962758945676427 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 1/1183 36/18639 0.0277777777777778 0.437658495350803 0.905854324891515 0.962758945676427 GO:0005484 SNAP receptor activity 1/1183 36/18639 0.0277777777777778 0.437658495350803 0.905854324891515 0.962758945676427 GO:0045505 dynein intermediate chain binding 1/1183 36/18639 0.0277777777777778 0.437658495350803 0.905854324891515 0.962758945676427 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 2/1183 61/18639 0.0327868852459016 0.516580519102587 0.906327249038199 0.962758945676427 GO:0016836 hydro-lyase activity 2/1183 61/18639 0.0327868852459016 0.516580519102587 0.906327249038199 0.962758945676427 GO:0015179 L-amino acid transmembrane transporter activity 2/1183 62/18639 0.032258064516129 0.508248575246094 0.91112941468539 0.964974831975979 GO:0016874 ligase activity 7/1183 167/18639 0.0419161676646707 0.660418807355703 0.911585536564736 0.964974831975979 GO:0019213 deacetylase activity 1/1183 37/18639 0.027027027027027 0.425829887368349 0.911841226662915 0.964974831975979 GO:0070001 aspartic-type peptidase activity 1/1183 37/18639 0.027027027027027 0.425829887368349 0.911841226662915 0.964974831975979 GO:1901682 sulfur compound transmembrane transporter activity 2/1183 63/18639 0.0317460317460317 0.500181137543775 0.915700010409796 0.968148555606977 GO:0042887 amide transmembrane transporter activity 1/1183 38/18639 0.0263157894736842 0.414623837700761 0.917447711388093 0.969086419346147 GO:0046873 metal ion transmembrane transporter activity 22/1183 450/18639 0.0488888888888889 0.770278951817413 0.920939724295767 0.97186328918185 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 1/1183 39/18639 0.0256410256410256 0.403992457246895 0.922697932205678 0.972806995939694 GO:0071949 FAD binding 1/1183 40/18639 0.025 0.393892645815723 0.927614509958402 0.977075713950572 GO:0001530 lipopolysaccharide binding 1/1183 41/18639 0.024390243902439 0.3842855081129 0.932218630326122 0.980091669231758 GO:0015175 neutral L-amino acid transmembrane transporter activity 1/1183 41/18639 0.024390243902439 0.3842855081129 0.932218630326122 0.980091669231758 GO:0004252 serine-type endopeptidase activity 7/1183 176/18639 0.0397727272727273 0.626647391070468 0.935286886530926 0.981590430109378 GO:0004520 DNA endonuclease activity 1/1183 42/18639 0.0238095238095238 0.375135853157831 0.936530134806399 0.981590430109378 GO:0008307 structural constituent of muscle 1/1183 42/18639 0.0238095238095238 0.375135853157831 0.936530134806399 0.981590430109378 GO:0140098 catalytic activity, acting on RNA 18/1183 387/18639 0.0465116279069767 0.732823527099019 0.937131183274939 0.981590430109378 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1/1183 43/18639 0.0232558139534884 0.36641176354951 0.940567605932066 0.984274279070173 GO:0016790 thiolester hydrolase activity 1/1183 44/18639 0.0227272727272727 0.358084223468839 0.944348447090507 0.98731323251988 GO:0005216 monoatomic ion channel activity 21/1183 448/18639 0.046875 0.73854871090448 0.945464595058119 0.98756320411451 GO:0004180 carboxypeptidase activity 1/1183 46/18639 0.0217391304347826 0.342515344187585 0.951204401167734 0.991718662698953 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 1/1183 46/18639 0.0217391304347826 0.342515344187585 0.951204401167734 0.991718662698953 GO:0140359 ABC-type transporter activity 1/1183 47/18639 0.0212765957446809 0.335227783672956 0.954309074615729 0.99403516930371 GO:0016879 ligase activity, forming carbon-nitrogen bonds 1/1183 48/18639 0.0208333333333333 0.328243871513102 0.957216366178207 0.994964942726851 GO:0038187 pattern recognition receptor activity 1/1183 48/18639 0.0208333333333333 0.328243871513102 0.957216366178207 0.994964942726851 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 6/1183 167/18639 0.0359281437125748 0.566073263447745 0.958030716873388 0.994964942726851 GO:0004518 nuclease activity 8/1183 209/18639 0.0382775119617225 0.603089218473834 0.958736201473031 0.994964942726851 GO:0016830 carbon-carbon lyase activity 1/1183 51/18639 0.0196078431372549 0.30893540848292 0.964875408102048 0.999999224488041 GO:0046906 tetrapyrrole binding 5/1183 152/18639 0.0328947368421053 0.518279797125951 0.967961908849597 0.999999224488041 GO:0004497 monooxygenase activity 3/1183 106/18639 0.0283018867924528 0.445916202810252 0.968015810069504 0.999999224488041 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 1/1183 54/18639 0.0185185185185185 0.291772330233869 0.971164292344512 0.999999224488041 GO:0008374 O-acyltransferase activity 1/1183 55/18639 0.0181818181818182 0.286467378775071 0.972999785600172 0.999999224488041 GO:0030170 pyridoxal phosphate binding 1/1183 56/18639 0.0178571428571429 0.281351889868373 0.974718535795771 0.999999224488041 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 1/1183 56/18639 0.0178571428571429 0.281351889868373 0.974718535795771 0.999999224488041 GO:0099094 ligand-gated monoatomic cation channel activity 4/1183 136/18639 0.0294117647058824 0.46340311272438 0.97624636764662 0.999999224488041 GO:0070279 vitamin B6 binding 1/1183 57/18639 0.0175438596491228 0.276415891800507 0.976327962269085 0.999999224488041 GO:0008168 methyltransferase activity 7/1183 204/18639 0.0343137254901961 0.54063696484511 0.977233484357529 0.999999224488041 GO:0020037 heme binding 4/1183 142/18639 0.028169014084507 0.443822699510674 0.982049402727651 0.999999224488041 GO:0046943 carboxylic acid transmembrane transporter activity 6/1183 188/18639 0.0319148936170213 0.502841675509433 0.982053116181109 0.999999224488041 GO:0005342 organic acid transmembrane transporter activity 6/1183 189/18639 0.0317460317460317 0.500181137543775 0.982788163341489 0.999999224488041 GO:0016741 transferase activity, transferring one-carbon groups 7/1183 215/18639 0.0325581395348837 0.512976468969313 0.98529642765018 0.999999224488041 GO:0160215 deacylase activity 1/1183 65/18639 0.0153846153846154 0.242395474348137 0.986015536940995 0.999999224488041 GO:0030594 neurotransmitter receptor activity 2/1183 97/18639 0.0206185567010309 0.324859914074823 0.987068262570227 0.999999224488041 GO:0008173 RNA methyltransferase activity 1/1183 67/18639 0.0149253731343284 0.2351597885467 0.987740226879291 0.999999224488041 GO:0042626 ATPase-coupled transmembrane transporter activity 2/1183 98/18639 0.0204081632653061 0.321545016992427 0.987784299260977 0.999999224488041 GO:0003735 structural constituent of ribosome 5/1183 175/18639 0.0285714285714286 0.450163023789397 0.988316978084967 0.999999224488041 GO:0003777 microtubule motor activity 1/1183 68/18639 0.0147058823529412 0.23170155636219 0.988521150398665 0.999999224488041 GO:0098960 postsynaptic neurotransmitter receptor activity 1/1183 69/18639 0.0144927536231884 0.228343562791723 0.989252369992568 0.999999224488041 GO:0008028 monocarboxylic acid transmembrane transporter activity 1/1183 70/18639 0.0142857142857143 0.225081511894699 0.98993704669148 0.999999224488041 GO:0015171 amino acid transmembrane transporter activity 2/1183 102/18639 0.0196078431372549 0.30893540848292 0.990281195682556 0.999999224488041 GO:0004521 RNA endonuclease activity 1/1183 73/18639 0.0136986301369863 0.215831586748341 0.991740492342897 0.999999224488041 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 1/1183 73/18639 0.0136986301369863 0.215831586748341 0.991740492342897 0.999999224488041 GO:0048029 monosaccharide binding 1/1183 74/18639 0.0135135135135135 0.212914943684174 0.992266776817655 0.999999224488041 GO:0015276 ligand-gated monoatomic ion channel activity 5/1183 186/18639 0.0268817204301075 0.423540479371745 0.992939870835726 0.999999224488041 GO:0022834 ligand-gated channel activity 5/1183 188/18639 0.0265957446808511 0.419034729591194 0.993566151118434 0.999999224488041 GO:0140101 catalytic activity, acting on a tRNA 3/1183 139/18639 0.0215827338129496 0.340051205020768 0.994133687615018 0.999999224488041 GO:0022843 voltage-gated monoatomic cation channel activity 3/1183 143/18639 0.020979020979021 0.330539283202005 0.995258418514317 0.999999224488041 GO:0005244 voltage-gated monoatomic ion channel activity 4/1183 173/18639 0.023121387283237 0.364293776476969 0.996034758039 0.999999224488041 GO:0022832 voltage-gated channel activity 4/1183 175/18639 0.0228571428571429 0.360130419031518 0.996414128147166 0.999999224488041 GO:0050660 flavin adenine dinucleotide binding 1/1183 86/18639 0.0116279069767442 0.183205881774755 0.996491569126795 0.999999224488041 GO:0019842 vitamin binding 3/1183 150/18639 0.02 0.315114116652578 0.996743215304732 0.999999224488041 GO:0004519 endonuclease activity 2/1183 127/18639 0.015748031496063 0.248121351694943 0.99773004838671 0.999999224488041 GO:0015079 potassium ion transmembrane transporter activity 3/1183 160/18639 0.01875 0.295419484361792 0.998107805070669 0.999999224488041 GO:0022836 gated channel activity 8/1183 318/18639 0.0251572327044025 0.396369958053558 0.999528629483978 0.999999224488041 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1/1183 122/18639 0.00819672131147541 0.129145129775647 0.999673418573163 0.999999224488041 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 1/1183 132/18639 0.00757575757575758 0.119361407822946 0.999831266589993 0.999999224488041 GO:0045182 translation regulator activity 6/1183 356/18639 0.0168539325842697 0.265545603920712 0.999994782770015 0.999999224488041 GO:0030371 translation repressor activity 4/1183 329/18639 0.0121580547112462 0.191558733527403 0.999999224488041 0.999999224488041