category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	35/671	180/9376	2.71700612684219	BST2/OAS2/STAT1/OAS1/B2M/EIF2AK2/OAS3/SRSF7/IRF9/PIK3R1/AKT3/BIRC3/IFIH1/HLA-C/CD74/CCL5/SP100/PPP1CB/HLA-A/IFNG/HLA-DPB1/HLA-F/HLA-B/HLA-DRA/TAB2/AKT1/ZC3HAV1/TAP1/POU2F1/TRAF6/HLA-DQA1/IL1B/AKT2/NXF1/BIRC2	6.45759979865752
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	29/671	133/9376	3.04678238069092	CREB3L2/AKT3/MAPK10/GNAQ/FOS/PPP3CA/GRIA1/PPP1CB/PLCB1/GNB2/ITPR2/PPP2R1A/PRKCA/GNB1/GNAI1/AKT1/CAMK2D/PPP2R5E/PLCB3/GRIA3/CREB3L1/ATF2/PLCB4/PPP2R3C/CREB3L4/PPP2CB/AKT2/PRKACA/ARRB1	6.60014572261084
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	39/671	227/9376	2.4006775343527	CCL4/CREB3L2/B2M/CCL3/PIK3R1/CDK6/AKT3/GNAQ/PPP3CA/HLA-C/PTK2/CCL3L1/CCL5/PLCB1/CCL4L2/ADCY3/HLA-A/GNB2/ITPR2/CXCR4/PRKCA/SOS1/GNB1/HLA-F/GNAI1/HLA-B/AKT1/CTNNB1/RAC2/PLCB3/CREB3L1/ATF2/PLCB4/TAP1/IL1B/CREB3L4/AKT2/PRKACA/KRAS	5.93098449052107
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	27/671	130/9376	2.90212082998968	COL3A1/COL1A1/COL1A2/CREB3L2/PIK3R1/AKT3/MAPK10/FOS/PLCB1/ADCY3/GNB2/PRKCA/SOS1/GNB1/MMP2/GNAI1/AKT1/SMAD2/PLCB3/CREB3L1/ATF2/PLCB4/CREB3L4/AKT2/PRKACA/KRAS/ARRB1	6.06310855070154
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	25/671	122/9376	2.86335540299528	STAT1/CREB3L2/PIK3R1/AKT3/MAPK10/GNAQ/FOS/PTK2/PLCB1/ADCY3/ITPR2/PRKCA/SOS1/GNAI1/AKT1/CREBBP/PLCB3/CREB3L1/ATF2/JUNB/PLCB4/CREB3L4/AKT2/PRKACA/KRAS	5.75139738090116
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	27/671	139/9376	2.71421372588963	FKBP5/CREB3L2/NCOA2/GREB1/PIK3R1/AKT3/GNAQ/FOS/NCOA1/KRT18/PLCB1/ADCY3/ITPR2/SOS1/MMP2/GNAI1/AKT1/PLCB3/CREB3L1/ATF2/PLCB4/HSPA1A/CREB3L4/ESR1/AKT2/PRKACA/KRAS	5.65287532445866
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	32/671	193/9376	2.31679574990541	STAT1/CCL4/CCL3/PIK3R1/AKT3/XCL2/GNAQ/XCL1/PTK2/CCL3L1/CCL5/PARD3/PLCB1/CCL4L2/ADCY3/GNB2/CXCR4/SOS1/GNB1/ELMO1/GNAI1/AKT1/RAC2/PLCB3/PLCB4/DOCK2/LYN/AKT2/PRKACA/BRAF/KRAS/ARRB1	5.13177124639676
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	30/671	178/9376	2.35502938763208	SFRP4/TLE1/DKK1/APCDD1/MAPK10/TBL1X/PPP3CA/TCF7L2/PLCB1/CSNK1A1/PRKCA/DAAM1/SMAD3/CREBBP/CTNNB1/TLE4/CAMK2D/SOX17/RAC2/PLCB3/LGR5/FZD1/PLCB4/DVL3/RBX1/INVS/DKK2/DAAM2/LZTS2/PRKACA	5.06727557523541
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	35/671	224/9376	2.1833084947839	CREB3L2/B2M/PIK3R1/AKT3/MSX1/MAPK10/FOS/PPP3CA/HLA-C/IL15/ADCY3/HLA-A/HLA-DPB1/HLA-F/IL2RB/HLA-B/HLA-DRA/AKT1/SMAD3/SMAD2/CREBBP/ITGB2/CREB3L1/ATF2/IL2RG/CRTC2/CDC23/SLC2A1/HLA-DQA1/POLB/CREB3L4/AKT2/PRKACA/KRAS/XPO1	4.97652850792809
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	21/671	103/9376	2.84889962814521	CCL3/PIK3R1/AKT3/MAPK10/GNAQ/FOS/CCL3L1/CCL5/PLCB1/IFNG/PPP2R1A/CD247/GNAI1/AKT1/SMAD2/PLCB3/PLCB4/TRAF6/IL1B/PPP2CB/AKT2	5.23822716108913
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	29/671	173/9376	2.34232402677395	MX1/OAS2/STAT1/OAS1/EIF2AK2/OAS3/IRF9/PIK3R1/CDK6/AKT3/MX2/ADAR/RSAD2/IFIH1/CCL5/IFNG/RAB11A/PRKCA/HLA-DPB1/HLA-DRA/NXT1/AKT1/CREBBP/TNFRSF10B/HLA-DQA1/IL1B/AKT2/NXF1/XPO1	4.9474135590003
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	27/671	156/9376	2.4184340249914	MX1/OAS2/STAT1/OAS1/PIAS1/IFIT1/EIF2AK2/YWHAZ/OAS3/IRF9/PIK3R1/CDK6/AKT3/MX2/RSAD2/IFNG/PPP2R1A/SOS1/AKT1/CTNNB1/CLDN7/TRAF6/PPARA/PPP2CB/AKT2/BRAF/KRAS	4.9598493978254
Organismal Systems	Nervous system	hsa04730	Long-term depression	15/671	60/9376	3.49329359165425	GNAQ/GRIA1/PLCB1/ITPR2/PPP2R1A/PRKCA/GNAI1/PLCB3/GRIA3/IGF1R/PLCB4/LYN/PPP2CB/BRAF/KRAS	5.37894144526149
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	22/671	115/9376	2.67312900926586	CREB3L2/PIK3R1/AKT3/GNAQ/FOS/PLCB1/ADCY3/GNB2/ITPR2/PRKCA/GNB1/GNAI1/AKT1/CAMK2D/PLCB3/CREB3L1/PLCB4/KCNQ5/CREB3L4/AKT2/PRKACA/KRAS	5.01200987330005
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	23/671	125/9376	2.57106408345753	PIK3R1/AKT3/MAPK10/GNAQ/PLCB1/PPP2R1A/PRKCA/GNAI1/AKT1/PPP2R5E/RAC2/PLCB3/ORMDL3/FCER1G/PLCB4/CERS5/SGPP1/NSMAF/S1PR2/PPP2R3C/PPP2CB/AKT2/KRAS	4.90927179402477
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	45/671	333/9376	1.88826680629959	ISG15/COL1A1/COL6A1/MX1/COL1A2/STAT1/CREB3L2/COL6A3/EIF2AK2/IRF9/LAMA2/PIK3R1/PDGFRB/CDK6/AKT3/MX2/ITGB8/HLA-C/MAML2/PTK2/PARD3/TCF7L2/HLA-A/CSNK1A1/PPP2R1A/SOS1/HLA-F/CHD4/HLA-B/AKT1/ATP6V1G1/CREBBP/CTNNB1/PPP2R5E/CREB3L1/THBS3/FZD1/DVL3/PPP2R3C/CREB3L4/PPP2CB/AKT2/PRKACA/KRAS/HES4	4.58217630417632
Human Diseases	Infectious disease: viral	hsa05162	Measles	24/671	136/9376	2.46585429999123	MX1/OAS2/STAT1/OAS1/EIF2AK2/OAS3/IRF9/PIK3R1/CDK6/AKT3/MX2/MAPK10/ADAR/IFIH1/FOS/IL2RB/TAB2/AKT1/IL2RG/TRAF6/IL1B/RAB9A/HSPA1A/AKT2	4.7806481846291
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	26/671	157/9376	2.31402887600027	SNAI2/CTNNA2/YWHAZ/CTNNA3/BIRC3/STK3/PARD3/TCF7L2/PPP1CB/BMP8A/PPP2R1A/LIMD1/CTNNA1/SMAD3/SMAD2/ITGB2/CTNNB1/BMPR1B/FZD1/DVL3/MOB1A/BMPR2/TEAD3/BMPR1A/PPP2CB/BIRC2	4.6097284031126
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	22/671	122/9376	2.51975275463585	STAT1/NCOA2/PIK3R1/AKT3/NCOA1/PLCB1/PRKCA/AKT1/MED12L/CREBBP/MED30/CTNNB1/PLCB3/HIF1A/PLCB4/SLC2A1/MED16/MED14/ESR1/AKT2/PRKACA/KRAS	4.69083997533673
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	21/671	115/9376	2.55162314520832	CREB3L2/MMP16/GNAQ/FOS/PLCB1/ADCY3/NR4A2/ITPR2/PRKCA/GNAI1/WNK1/PLCB3/CREB3L1/MAFB/ATF2/PLCB4/CREB3L4/MEF2A/PRKACA/BRAF/ARRB1	4.64802802435258
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	20/671	107/9376	2.61180829282561	CREB3L2/AKT3/GNAQ/PPP3CA/PLCB1/ITPR2/AKT1/CREBBP/CPT1C/CAMK2D/PLCB3/CREB3L1/ATF2/PLCB4/CRTC2/SLC2A1/CREB3L4/PPARA/AKT2/PRKACA	4.65533934945915
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	24/671	142/9376	2.36166327323104	PIK3R1/AKT3/MAPK10/FOS/PTK2/GSTT2B/MGST1/CTSL/IFNG/MMP2/AKT1/CTNNB1/RAC2/KLF2/BMPR1B/GSTA4/DUSP1/IL1B/GSTO2/BMPR2/MEF2A/BMPR1A/NQO1/AKT2	4.53922250323183
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	19/671	101/9376	2.62861696005666	CREB3L2/GNAQ/MITF/TCF7L2/PLCB1/ADCY3/PRKCA/GNAI1/CREBBP/CTNNB1/CAMK2D/PLCB3/CREB3L1/FZD1/PLCB4/DVL3/CREB3L4/PRKACA/KRAS	4.56862162840223
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	18/671	93/9376	2.70448536128071	SNAI2/CTNNA2/CTNNA3/PARD3/TCF7L2/HEG1/BAIAP2/PTPRF/CTNNA1/SMAD3/CREBBP/CTNNB1/RAC2/IGF1R/PTPRJ/PTPN1/IQGAP1/SSX2IP	4.58620100661223
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	25/671	154/9376	2.26837246211315	CREB3L2/AKT3/GNAQ/SLC8A1/PPP1CB/PLCB1/ADCY3/PPP2R1A/PRKCA/ATP2B4/GNAI1/AKT1/CAMK2D/PPP2R5E/PLCB3/CREB3L1/ATF2/RYR2/PLCB4/CACNA2D1/PPP2R3C/CREB3L4/PPP2CB/AKT2/PRKACA	4.40612807091413
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	31/671	214/9376	2.02415142693984	BST2/B2M/PIK3R1/AKT3/MAPK10/GNAQ/FOS/PPP3CA/HLA-C/PTK2/HLA-A/GNB2/PAK3/ITPR2/CXCR4/CD247/PRKCA/GNB1/HLA-F/GNAI1/HLA-B/TAB2/AKT1/RAC2/AP1M1/TAP1/APOBEC3C/RBX1/TRAF6/AKT2/KRAS	4.20763857446065
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	11/671	44/9376	3.49329359165425	HLA-C/HLA-A/IFNG/GZMB/CPE/HLA-DPB1/HLA-F/HLA-B/HLA-DRA/HLA-DQA1/IL1B	4.60229978677965
Organismal Systems	Immune system	hsa04611	Platelet activation	21/671	126/9376	2.32886239443616	COL3A1/COL1A1/COL1A2/PIK3R1/AKT3/GNAQ/PPP1CB/PLCB1/ADCY3/STIM1/ITPR2/APBB1IP/GNAI1/AKT1/PLCB3/FCER1G/PLCB4/LYN/AKT2/PRKACA/MYLK3	4.16924031149672
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	16/671	83/9376	2.69362397428761	RYBP/AUTS2/KDM2A/MBD5/UBE2D3/PCGF2/CREBBP/PHF1/E2F6/MTF2/L3MBTL3/SCML2/PHC3/L3MBTL4/TEX10/FBRS	4.30269518894472
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	14/671	67/9376	2.91976777809907	GNAQ/PPP3CA/GRIA1/PPP1CB/PLCB1/ITPR2/PRKCA/CREBBP/CAMK2D/PLCB3/PLCB4/PRKACA/BRAF/KRAS	4.37821510368558
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	11/671	45/9376	3.41566484517304	HLA-C/HLA-A/IFNG/GZMB/HLA-DPB1/HLA-F/HLA-B/HLA-DRA/HLA-DQA1/IL1B/KLRC1	4.50963457844732
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	24/671	155/9376	2.16358828902457	CREB3L2/PBX1/CDK6/GNAQ/TCF7L2/PLCB1/RASD1/ADCY3/ITPR2/GNAI1/CTNNB1/CAMK2D/PLCB3/CREB3L1/ATF2/FZD1/PLCB4/KMT2A/DVL3/MEN1/CREB3L4/PRKACA/BRAF/PDE8A	4.05544662843022
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	18/671	101/9376	2.49026869900105	COL3A1/COL1A1/COL1A2/STAT1/PIK3R1/AKT3/MAPK10/PLCB1/PRKCA/MMP2/AKT1/SMAD3/SMAD2/PLCB3/PLCB4/IL1B/AKT2/KRAS	4.18052493457403
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	25/671	166/9376	2.1043937299122	EDNRA/CREB3L2/AKT3/GNAQ/PPP3CA/SLC8A1/PPP1CB/PLCB1/ADCY3/ITPR2/ATP2B4/GNAI1/AKT1/RGS2/PLCB3/CREB3L1/ATF2/PLCB4/PPIF/NPR1/CREB3L4/MEF2A/AKT2/NPR2/MYLK3	3.98575566271715
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	25/671	170/9376	2.05487858332603	ARID1B/PIK3R1/CDK6/AKT3/GSTT2B/TCF7L2/MGST1/CSNK1A1/PRKCA/SOS1/SMARCA2/AKT1/SMAD3/SMAD2/CTNNB1/PBRM1/IGF1R/FZD1/DVL3/GSTA4/GSTO2/NQO1/AKT2/BRAF/KRAS	3.85348755828203
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	16/671	89/9376	2.51203134680755	TUBB/GJA1/PDGFRB/GNAQ/PLCB1/ADCY3/ITPR2/PRKCA/SOS1/GNAI1/PLCB3/PLCB4/MAP3K2/HTR2A/PRKACA/KRAS	3.97906089864437
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	14/671	73/9376	2.67978686483066	BST2/MX1/MX2/MLLT3/CXCR4/CREBBP/NELFCD/SERINC3/HGS/APOBEC3C/SUPT5H/CDK9/NUP153/XPO1	4.00006097073977
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	13/671	65/9376	2.7946348733234	CREB3L2/PBX1/GNAQ/PLCB1/ADCY3/ITPR2/PLCB3/CREB3L1/ATF2/PLCB4/CREB3L4/PRKACA/PDE8A	4.0308545590293
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	17/671	99/9376	2.39943398214635	DGKB/PLPP3/PIK3R1/PDGFRB/AKT3/MAPK10/FOS/PIP5K1B/PRKCA/SOS1/AKT1/GPCPD1/RAC2/PCYT1A/HIF1A/AKT2/KRAS	3.88623219346674
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	28/671	204/9376	1.91788667777096	COL1A1/COL1A2/PIK3R1/AKT3/DDX5/ERBB4/PTK2/PPP1CB/HOXD10/ITPR2/CTSL/PRKCA/SOS1/MMP2/AKT1/SMAD2/CTNNB1/PLAUR/CAMK2D/HIF1A/IGF1R/FZD1/IQGAP1/ESR1/AKT2/PRKACA/BRAF/KRAS	3.67988831325642
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	28/671	205/9376	1.90853113300135	ISG15/OAS2/STAT1/OAS1/B2M/EIF2AK2/OAS3/IRF9/PIK3R1/CDK6/AKT3/MAPK10/HLA-C/HLA-A/CD247/HLA-DPB1/HLA-F/HLA-B/HLA-DRA/TAB2/AKT1/RUNX3/SKP2/TAP1/TRAF6/HLA-DQA1/LYN/AKT2	3.65149666566605
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	19/671	119/9376	2.2310110333254	CREB3L2/PIK3R1/AKT3/BIRC3/MAPK10/FOS/CCL5/IL15/ITCH/TAB2/AKT1/BCL3/CREB3L1/ATF2/JUNB/IL1B/CREB3L4/AKT2/BIRC2	3.75199978516303
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	12/671	59/9376	2.84200156609159	CTNNA2/CTNNA3/PIK3R1/AKT3/TCF7L2/SOS1/CTNNA1/AKT1/CTNNB1/AKT2/BRAF/KRAS	3.94040139126724
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	21/671	140/9376	2.09597615499255	AKT3/GNAQ/SLC8A1/PLCB1/ADCY3/GNB2/ITPR2/GNB1/GNAI1/AKT1/SMAD3/SMAD2/PLCB3/KLF2/RYR2/PLCB4/MEF2A/AKT2/PRKACA/MYLK3/KRAS	3.62731833931525
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	15/671	86/9376	2.43718157557273	CREB3L2/GNAQ/PCLO/PLCB1/ADCY3/PRKCA/CAMK2D/PLCB3/CREB3L1/ATF2/RYR2/PLCB4/SLC2A1/CREB3L4/PRKACA	3.71719650521112
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	11/671	53/9376	2.90009279307145	GNAQ/SLC8A1/PLCB1/RAB11A/PRKCA/ATP2B4/PLCB3/PLCB4/CLTC/ESR1/PRKACA	3.85121189184438
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	28/671	212/9376	1.84551359559092	PIK3R1/PDGFRB/AKT3/GNAQ/MAGI2/PARD3/PLCB1/ADCY3/SKAP1/APBB1IP/PRKCA/GNAI1/EVL/AKT1/ITGB2/CTNNB1/RAC2/PLCB3/EFNA5/FYB1/IGF1R/PFN2/PLCB4/LPAR3/AKT2/BRAF/KRAS/RAPGEF2	3.45707256866409
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	20/671	133/9376	2.10122922806271	PIK3R1/PPP3CA/HLA-C/HLA-A/IFNG/GZMB/CD247/PRKCA/SOS1/HLA-B/HCST/ITGB2/RAC2/FCER1G/CD48/TNFRSF10B/KLRK1/KLRC1/BRAF/KRAS	3.55107286821503
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	13/671	70/9376	2.59501809665744	PIK3R1/AKT3/PAK3/SOS1/AKT1/CREBBP/HIF1A/RBX1/SLC2A1/TFE3/AKT2/BRAF/KRAS	3.71873833933383
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	27/671	203/9376	1.85850102413132	COL1A1/COL6A1/COL1A2/COL6A3/LAMA2/PIK3R1/PDGFRB/AKT3/BIRC3/MAPK10/ITGB8/PTK2/PPP1CB/PAK3/PIP5K1B/PRKCA/SOS1/AKT1/CTNNB1/RAC2/THBS3/IGF1R/EMP1/AKT2/BRAF/MYLK3/BIRC2	3.43317269928118
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	16/671	97/9376	2.30485350377187	GNAQ/FOS/GRIA1/PLCB1/RASD1/ADCY3/GNB2/PRKCA/GNB1/GNAI1/CAMK2D/PLCB3/GRIA3/RYR2/PLCB4/PRKACA	3.58640677596132
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	13/671	71/9376	2.55846854600029	STAT1/PRLR/PIK3R1/AKT3/MAPK10/FOS/SOS1/AKT1/LHCGR/GALT/ESR1/AKT2/KRAS	3.6595824623551
Human Diseases	Immune disease	hsa05330	Allograft rejection	9/671	39/9376	3.22457869998854	HLA-C/HLA-A/IFNG/GZMB/HLA-DPB1/HLA-F/HLA-B/HLA-DRA/HLA-DQA1	3.86490576455366
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	16/671	98/9376	2.28133459046808	CREB3L2/GNAQ/PLCB1/ADCY3/NR4A2/ITPR2/PRKCA/ATP2B4/CAMK2D/PLCB3/CREB3L1/ATF2/PLCB4/NPR1/CREB3L4/PRKACA	3.54006237850635
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	14/671	82/9376	2.38566391625168	B2M/HLA-C/CD74/HLA-A/CTSL/IFNG/HLA-DPB1/HLA-F/HLA-B/HLA-DRA/TAP1/HLA-DQA1/KLRC1/HSPA1A	3.4988555290094
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	12/671	65/9376	2.57966295999083	PIK3R1/AKT3/GNAQ/PLCB1/ITPR2/PRKCA/AKT1/PLCB3/PLCB4/AKT2/KRAS/ARRB1	3.54801510806334
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	15/671	93/9376	2.25373780106726	STAT1/MAPK10/FOS/PPP3CA/MAML2/IFNG/MAF/CD247/HLA-DPB1/IL2RB/HLA-DRA/RUNX3/STAT4/IL2RG/HLA-DQA1	3.37338981953011
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	17/671	112/9376	2.12092825207579	STAT1/LAMA2/AKT3/BIRC3/MAPK10/IFNG/HLA-DPB1/GNAI1/HLA-DRA/TAB2/AKT1/TRAF6/PPIF/HLA-DQA1/HSPA1A/AKT2/BIRC2	3.3132183960781
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	18/671	122/9376	2.06161589015661	PIK3R1/AKT3/PTPRC/MAPK10/FOS/PPP3CA/PAK3/IFNG/PPP2R1A/CD247/SOS1/BCL10/AKT1/PPP2R5E/PPP2R3C/PPP2CB/AKT2/KRAS	3.27676343458415
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	22/671	163/9376	1.88594991451272	STAT1/CREB3L2/YWHAZ/PIK3R1/AKT3/MAPK10/IFIH1/FOS/PRKCA/SOS1/TAB2/AKT1/SMAD3/CREBBP/STAT4/CREB3L1/ATF2/TRAF6/CREB3L4/AKT2/BRAF/KRAS	3.16785246913819
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	21/671	154/9376	1.90543286817504	GNAQ/FOS/PPP3CA/PPP1CB/PLCB1/ADCY3/ITPR2/PRKCA/GNAI1/RGS2/CAMK2D/PLCB3/CAMKK2/RYR2/PLCB4/CACNA2D1/NPR1/PRKACA/NPR2/MYLK3/KRAS	3.14533253910906
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	27/671	216/9376	1.74664679582712	ABCA1/CCL3/PIK3R1/AKT3/MAPK10/MIB1/FOS/PPP3CA/PTK2/CCL3L1/CCL5/PLCB1/PRKCA/TAB2/AKT1/CAMK2D/PLCB3/PLCB4/POU2F1/TRAF6/DDIT3/TNFRSF10B/IL1B/HSPA1A/LYN/AKT2/KRAS	3.08217188801706
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	12/671	69/9376	2.43011728115078	CREB3L2/FOS/PPP3CA/GRIA1/PPP1CB/PRKCA/CAMK2D/GRIA3/CREB3L1/ATF2/CREB3L4/PRKACA	3.31019709756831
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	14/671	87/9376	2.24855679462802	PIK3R1/AKT3/MAPK10/FOS/TCF7L2/SOS1/AKT1/SMAD3/SMAD2/CTNNB1/RAC2/AKT2/BRAF/KRAS	3.2482239025295
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	30/671	250/9376	1.67678092399404	EPS15/HLA-C/PARD3/HLA-A/PIP5K1B/RAB11A/CXCR4/ITCH/ZFYVE27/HLA-F/IL2RB/HLA-B/CAPZA1/SMAD3/SMAD2/CHMP1B/ACTR2/ACAP2/IL2RG/IGF1R/HGS/CHMP2B/TRAF6/ARAP2/VPS37A/HSPA1A/CLTC/RAB31/ARRB1/ARF1	3.01120547709828
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	11/671	62/9376	2.47911158117398	ATXN1/TLE1/MAML2/ITCH/NUMB/DTX3L/CREBBP/TLE4/DTX1/DVL3/DTX3	3.24407716544528
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	15/671	99/9376	2.1171476313056	PIK3R1/AKT3/MAPK10/FOS/PTK2/ADCY3/SOS1/MMP2/AKT1/IGF1R/ESR1/AKT2/PRKACA/BRAF/KRAS	3.10232218527113
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	15/671	99/9376	2.1171476313056	PIK3R1/MAPK10/GNAQ/PPP1CB/PLCB1/ADCY3/ITPR2/PRKCA/PRKCH/CAMK2D/PLCB3/PLCB4/IL1B/HTR2A/PRKACA	3.10232218527113
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	16/671	109/9376	2.05110816390708	STAT1/CCL4/CCL3/IRF9/PIK3R1/AKT3/MAPK10/FOS/CCL3L1/CCL5/CCL4L2/TAB2/AKT1/TRAF6/IL1B/AKT2	3.0644573915229
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	14/671	90/9376	2.17360490147375	CREB3L2/PIK3R1/AKT3/ADCY3/AKT1/EHMT1/CAMKK2/CREB3L1/ATF2/IGF1R/CREB3L4/AKT2/PRKACA/KRAS	3.10592768767606
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	16/671	110/9376	2.03246172605338	BMP8A/IFNG/PPP2R1A/THSD4/SMAD3/SMAD2/CREBBP/GREM2/BMPR1B/RBX1/RGMB/LEMD3/BMPR2/BMPR1A/PPP2CB/TGIF1	3.02403397592828
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	14/671	93/9376	2.10348861432944	MAPK10/GNAQ/PLCB1/ADCY3/ITPR2/PRKCA/SOS1/MMP2/CAMK2D/PLCB3/PLCB4/MAP3K2/PRKACA/KRAS	2.96911942383608
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	15/671	103/9376	2.03492830581801	COL3A1/COL1A1/COL1A2/LAMA2/PIK3R1/GNAQ/PTK2/PLCB1/IFNG/PRKCA/ITGB2/PLCB3/PLCB4/IL1B/PRKACA	2.93211674597734
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	39/671	362/9376	1.50539723839244	COL1A1/COL6A1/COL1A2/CREB3L2/COL6A3/YWHAZ/PRLR/LAMA2/PIK3R1/PDGFRB/CDK6/AKT3/ITGB8/MAGI2/ERBB4/PTK2/GNB2/PPP2R1A/PRKCA/SOS1/GNB1/IL2RB/AKT1/PPP2R5E/CREB3L1/EFNA5/THBS3/ATF2/IL2RG/IGF1R/CRTC2/IL7/LPAR3/PPP2R3C/FLT3LG/CREB3L4/PPP2CB/AKT2/KRAS	2.72264415480593
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	12/671	75/9376	2.23570789865872	CREB3L2/GNAQ/PLCB1/ADCY3/ITPR2/PRKCA/PLCB3/CREB3L1/ATF2/PLCB4/CREB3L4/PRKACA	2.98293742351486
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	24/671	196/9376	1.71100094285106	STAT1/EIF2AK2/IRF9/PIK3R1/CDK6/AKT3/MAPK10/FOS/PPP3CA/HLA-C/TCF7L2/HLA-A/GNB2/ITPR2/GNB1/HLA-F/HLA-B/AKT1/CREBBP/CTNNB1/HIF1A/LYN/AKT2/KRAS	2.79279708352247
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	11/671	66/9376	2.32886239443616	STAT1/IFNG/MAF/HLA-DPB1/HLA-DRA/SMAD3/SMAD2/STAT4/IL2RG/HLA-DQA1/IL1B	3.00773555212854
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	19/671	144/9376	1.84368272892863	ATXN1/PIK3R1/AKT3/MAPK10/GNAQ/GRIA1/PLCB1/PUM1/ITPR2/PUM2/PRKCA/AKT1/PLCB3/GRIA3/PLCB4/PPIF/ATXN2/AKT2/CIC	2.83253325557774
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	12/671	76/9376	2.20629068946584	GNAQ/PLCB1/ADCY3/ITPR2/PRKCA/GNAI1/CAMK2D/PLCB3/PLCB4/SLC4A2/PRKACA/MYLK3	2.93143189107116
Human Diseases	Cancer: specific types	hsa05214	Glioma	12/671	76/9376	2.20629068946584	PIK3R1/PDGFRB/CDK6/AKT3/PRKCA/SOS1/AKT1/CAMK2D/IGF1R/AKT2/BRAF/KRAS	2.93143189107116
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	14/671	95/9376	2.05920464350145	CCL3/FOS/CCL3L1/CCL5/IL15/CTSL/IFNG/HLA-DPB1/HLA-DRA/ATP6V1G1/ITGB2/HLA-DQA1/IL1B/ACP5	2.88075817430101
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	13/671	86/9376	2.11222403216303	PIK3R1/AKT3/MAPK10/ERBB4/PTK2/PAK3/PRKCA/SOS1/AKT1/CAMK2D/AKT2/BRAF/KRAS	2.87671046974052
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	13/671	86/9376	2.11222403216303	CTNNA2/CTNNA3/GJA1/LAMA2/ITGB8/SLC8A1/TCF7L2/CTNNA1/PKP2/CTNNB1/RYR2/CACNA2D1/SNTB1	2.87671046974052
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	12/671	77/9376	2.17763756362862	STAT1/PIK3R1/CDK6/AKT3/MAPK10/AKT1/SMAD3/SMAD2/RAC2/AKT2/BRAF/KRAS	2.88072233204236
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	15/671	106/9376	1.97733599527599	CREB3L2/PIK3R1/PDGFRB/AKT3/TCF7L2/SOS1/AKT1/CREBBP/CTNNB1/CREB3L1/IGF1R/CREB3L4/AKT2/BRAF/KRAS	2.8094381159429
NA	NA	hsa04517	IgSF CAM signaling	33/671	299/9376	1.542189813038	TUBB/PIK3R1/AKT3/MAPK10/MAGI2/PTK2/PARD3/TRIO/PAK3/APP/SRGAP3/BAIAP2/PRKCA/PTPRF/NCAM1/AKT1/CADM2/ITGB2/CTNNB1/MYH9/ACTR2/IQGAP1/CD48/CD96/TRAF6/CSK/SSX2IP/PTPRD/LYN/NTRK3/AKT2/MYLK3/RAPGEF2	2.64532045754212
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	16/671	116/9376	1.92733439539545	GNAQ/PPP3CA/GRIA1/PLCB1/ADCY3/GNB2/ITPR2/PRKCA/GNB1/GNAI1/PLCB3/GRIA3/NCDN/PLCB4/GLUL/PRKACA	2.79011677460857
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	27/671	233/9376	1.61920904677536	COL3A1/NID1/COL1A1/COL6A1/COL1A2/ELN/COL5A2/COL6A3/LAMA2/ITGB8/DAAM1/CAPZA1/PKP2/LBR/NEBL/MYH9/DIAPH2/THBS3/AMPD2/LMNB2/TTN/SNTB1/ANKRD23/SYNE3/SDC3/DAAM2/CSRP2	2.657256047071
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	20/671	158/9376	1.76875624893886	YWHAZ/CDK6/PPP2R1A/NIPBL/STAG2/SMAD3/SMAD2/CREBBP/PPP2R5E/TFDP2/SKP2/CDC23/RBX1/MCM7/NDC80/DBF4/ZBTB17/MTBP/PPP2CB/ORC2	2.70558611306093
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	11/671	69/9376	2.22760750772155	PIK3R1/AKT3/MAPK10/PRKCA/SOS1/AKT1/RAC2/FCER1G/LYN/AKT2/KRAS	2.84146123018879
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	11/671	70/9376	2.19578454332553	LAMA2/HLA-C/HLA-A/HLA-DPB1/HLA-F/HLA-B/HLA-DRA/ITGB2/RAC2/HLA-DQA1/SNTB1	2.78793691191735
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	15/671	109/9376	1.92291390366289	STAT1/MAPK10/FOS/PPP3CA/IFNG/CD247/HLA-DPB1/IL2RB/HLA-DRA/SMAD3/SMAD2/HIF1A/IL2RG/HLA-DQA1/IL1B	2.69071293605613
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	15/671	109/9376	1.92291390366289	CREB3L2/PIK3R1/AKT3/MAPK10/PPP1CB/PTPRF/AKT1/SREBF1/CREB3L1/PTPN1/CRTC2/SLC2A1/CREB3L4/PPARA/AKT2	2.69071293605613
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	28/671	248/9376	1.57761646074708	TUBB/AKT3/BIRC3/PTPRC/MAPK10/FOS/EXOC4/TCF7L2/PAK3/ELMO1/TAB2/AKT1/CTNNB1/ACTR2/ARL8A/PFN2/TRAF6/TNFRSF10B/DCTN5/PLEKHM2/IL1B/RHOH/RAB9A/AKT2/SNX18/VPS11/ARF1/BIRC2	2.55941137862608
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	26/671	226/9376	1.60753333421257	EDNRA/CREB3L2/PIK3R1/AKT3/MAPK10/FOS/GRIA1/PPP1CB/ADCY3/ATP2B4/GNAI1/AKT1/CREBBP/CAMK2D/RAC2/GRIA3/CREB3L1/RYR2/LHCGR/HHIP/NPR1/CREB3L4/PPARA/AKT2/PRKACA/BRAF	2.56670699951386
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	24/671	205/9376	1.63588382828687	COL3A1/MT-ND3/MT-CO3/COL1A1/COL1A2/PIK3R1/AKT3/MAPK10/PPP1CB/PLCB1/PRKCA/MMP2/AKT1/SMAD3/SMAD2/CAMK2D/RAC2/PLCB3/RYR2/PLCB4/SLC2A1/PPIF/PPARA/AKT2	2.55569412472409
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	11/671	71/9376	2.16485800046179	PIK3R1/PDGFRB/AKT3/IDH1/AKT1/HIF1A/SLC2A1/SLC16A3/NTRK3/AKT2/KRAS	2.73530955794034
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	10/671	62/9376	2.25373780106726	PIK3R1/AKT3/ADCY3/EIF4EBP2/AKT1/IGF1R/HSPA1A/AKT2/PRKACA/KRAS	2.74977373151908
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	18/671	142/9376	1.77124745492328	PIAS1/BIRC3/ITCH/UBE2D3/SYVN1/UBE2E2/FBXO4/PRKN/SKP2/UBE2H/CDC23/UBR5/RBX1/TRAF6/RHOBTB1/TRIP12/UBE3B/BIRC2	2.57102021606338
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	16/671	122/9376	1.83254745791698	CREB3L2/PIK3R1/AKT3/PPP2R1A/AKT1/SREBF1/CPT1C/PPP2R5E/CAMKK2/CREB3L1/IGF1R/CRTC2/PPP2R3C/CREB3L4/PPP2CB/AKT2	2.56972516420786
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	10/671	63/9376	2.2179641851773	AASS/KMT2C/PRDM6/KMT2E/EHMT1/GCDH/KMT5C/KMT2A/SETMAR/SMYD2	2.69291410853472
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	5/671	21/9376	3.32694627776595	XYLT1/CHSY3/CHPF/CHST14/CHST12	2.96371623267683
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	7/671	37/9376	2.64357352881943	GNAQ/PLCB1/IFNG/PRKCA/PLCB3/PLCB4/IL1B	2.78100854215181
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	12/671	83/9376	2.02021798071571	XDH/IDH1/ACOT8/CROT/PEX11B/GNPAT/PEX11G/PEX3/NUDT19/ACSL5/PEX5/DHRS4	2.59188997318417
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	17/671	134/9376	1.77271615098872	EDNRA/CALCRL/GNAQ/PPP1CB/PLCB1/ADCY3/ITPR2/PRKCA/PRKCH/PLCB3/MYH9/PLCB4/NPR1/PRKACA/BRAF/NPR2/MYLK3	2.5012201425187
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	15/671	115/9376	1.82258796086309	GNAQ/PLCB1/GNB2/APP/ITPR2/PRKCA/GNB1/GNAI1/PLCB3/PLCB4/DUSP1/HTR2A/PRKACA/BRAF/KRAS	2.46413693066775
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	23/671	201/9376	1.5989204499114	ZBTB16/PBX1/BIRC3/DDX5/PTK2/JMJD1C/MITF/MLLT3/MAF/GZMB/FUS/IL2RB/GRIA3/IGF1R/HOXA10/KMT2A/MEN1/DDIT3/TFE3/ZBTB17/CDK9/KDM6A/BIRC2	2.38301428075924
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	9/671	56/9376	2.24568873749202	MAN1A1/ALG11/DPAGT1/MOGS/TMEM258/ALG10B/MGAT4B/STT3B/ALG9	2.59572156862451
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	14/671	105/9376	1.86308991554893	STAT1/IRF9/PIK3R1/AKT3/MAPK10/PPP3CA/ITPR2/BCL10/AKT1/BCL3/FCER1G/IL1B/AKT2/KRAS	2.46916386038091
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	17/671	137/9376	1.73389754914225	PIK3R1/AKT3/BIRC3/MAPK10/FOS/ITPR2/CTSL/GZMB/CTSW/AKT1/PARP2/LMNB2/DDIT3/TNFRSF10B/AKT2/KRAS/BIRC2	2.40240237179649
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	17/671	138/9376	1.72133307414847	PIK3R1/AKT3/MAPK10/GNAQ/FOS/PTK2/PIP5K1B/BAIAP2/ELMO1/TAB2/AKT1/RAC2/ACTR2/FYB1/TRAF6/IL1B/AKT2	2.37000313490243
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	18/671	149/9376	1.68803448724232	DGKB/PLPP3/PIK3R1/PDGFRB/AKT3/PLCB1/ADCY3/PIP5K1B/PRKCA/SOS1/AKT1/PLCB3/FCER1G/PLCB4/LPAR3/AKT2/KRAS/ARF1	2.35036651890935
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	19/671	160/9376	1.65931445603577	PTPRC/ITGB8/HLA-C/HLA-A/PTPRF/HLA-DPB1/HLA-F/HLA-B/HLA-DRA/NRXN3/NCAM1/ITGB2/CLDN7/NTNG1/GLG1/HLA-DQA1/SDC3/PTPRD/IGSF11	2.33530638626975
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	23/671	205/9376	1.56772200210825	CREB3L2/EIF2AK2/YWHAZ/IRF9/PIK3R1/CDK6/HLA-C/SP100/HLA-A/HNRNPK/HLA-F/CHD4/HLA-B/CREBBP/CREB3L1/HDAC9/ATF2/SKP2/POLB/CREB3L4/LYN/PRKACA/KRAS	2.2817434894886
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	11/671	78/9376	1.97057587221522	CTNNA2/CTNNA3/PIK3R1/PTK2/SEPTIN2/ARHGAP10/ELMO1/CTNNA1/CTNNB1/ACTR2/CLTC	2.38970631842982
Organismal Systems	Endocrine system	hsa04924	Renin secretion	10/671	69/9376	2.02509773429232	EDNRA/GNAQ/PPP3CA/PLCB1/ITPR2/GNAI1/PLCB3/PLCB4/NPR1/PRKACA	2.37272536280926
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	31/671	300/9376	1.44389468455042	PDGFRB/AKT3/MAP3K20/MAPK10/STK3/FOS/PPP3CA/ERBB4/PRKCA/SOS1/TAB2/AKT1/TAOK1/RAC2/EFNA5/ATF2/IGF1R/CACNA2D1/DUSP1/TRAF6/DDIT3/IL1B/MAP3K2/FLT3LG/HSPA1A/AKT2/PRKACA/BRAF/KRAS/ARRB1/RAPGEF2	2.16948093946831
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	17/671	142/9376	1.67284481853865	STAT1/IRF9/PIK3R1/AKT3/MAPK10/FOS/PPP3CA/MITF/ITPR2/IFNG/TAB2/AKT1/JUNB/TRAF6/IL1B/ACP5/AKT2	2.2429865015353
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	25/671	232/9376	1.50572999640269	PIK3R1/PDGFRB/AKT3/ITGB8/PTK2/PPP1CB/PAK3/PIP5K1B/CXCR4/BAIAP2/SOS1/AKT1/ITGB2/RAC2/MYH9/ACTR2/DIAPH2/PFN2/ABI2/IQGAP1/C7/AKT2/BRAF/MYLK3/KRAS	2.16549461477226
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	9/671	60/9376	2.09597615499255	PIK3R1/AKT3/PPP3CA/PTK2/PRKCA/AKT1/RAC2/AKT2/KRAS	2.36441932985373
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	12/671	90/9376	1.86308991554893	STAT1/PIK3R1/AKT3/FOS/PPP3CA/IFNG/CD247/AKT1/HIF1A/TRAF6/AKT2/KRAS	2.28415445631757
NA	NA	hsa04518	Integrin signaling	18/671	154/9376	1.63322817272147	COL1A1/COL6A1/COL1A2/COL6A3/LAMA2/PIK3R1/PDGFRB/AKT3/ITGB8/PTK2/AKT1/ITGB2/CTNNB1/RAC2/FRAS1/THBS3/IGF1R/AKT2	2.19973589025525
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	17/671	144/9376	1.64961086272562	PIK3R1/AKT3/AKT1/SMAD3/PCGF2/SMAD2/CTNNB1/BMPR1B/IGF1R/FZD1/DVL3/KAT6A/BMPR2/BMPR1A/LIFR/AKT2/KRAS	2.18096721523679
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	12/671	91/9376	1.84261639999345	PIK3R1/AKT3/FOS/PPP3CA/SOS1/BCL10/AKT1/RAC2/IFITM1/LYN/AKT2/KRAS	2.24244686044116
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	4/671	17/9376	3.28780573332164	PCDH9/PCDH7/PCDH20/MYH9	2.62114708300945
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	13/671	102/9376	1.78089477221589	SCTR/GNAQ/SLC12A2/PLCB1/ADCY3/ITPR2/RAB11A/PRKCA/ATP2B4/PLCB3/RYR2/PLCB4/SLC4A2	2.20151458027022
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	19/671	168/9376	1.58029948193883	STAT1/PIAS1/PRLR/IRF9/PIK3R1/PDGFRB/AKT3/IL15/IFNG/SOS1/IL2RB/AKT1/CREBBP/IL20RA/STAT4/IL2RG/IL7/LIFR/AKT2	2.10710743224159
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	13/671	103/9376	1.76360453170894	COL3A1/COL1A1/COL6A1/COL1A2/ELN/COL5A2/COL6A3/MME/SLC7A8/SLC8A1/COL18A1/COL15A1/COL14A1	2.16341327427341
Organismal Systems	Digestive system	hsa04970	Salivary secretion	12/671	93/9376	1.8029902408538	GNAQ/SLC12A2/PLCB1/ADCY3/ITPR2/PRKCA/ATP2B4/PLCB3/LYZ/PLCB4/SLC4A2/PRKACA	2.160578632448
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	12/671	93/9376	1.8029902408538	LAMA2/PIK3R1/CDK6/AKT3/BIRC3/PTK2/AKT1/SKP2/TRAF6/ZBTB17/AKT2/BIRC2	2.160578632448
NA	NA	hsa04519	Cadherin signaling	39/671	404/9376	1.34889554529223	LHFPL3/CTNNA2/YWHAZ/CTNNA3/PCDH9/GJA1/PDGFRB/PCDH7/MAPK10/STK3/CDH11/PTK2/GABRA2/TCF7L2/KRT18/PPP1CB/PCDH20/CSNK1A1/LIMD1/DAAM1/RERE/CTNNA1/EVL/PKP2/TAOK1/CREBBP/CTNNB1/RAC2/ACTR2/IGF1R/FZD1/ABI2/ERBIN/DVL3/MOB1A/DAAM2/TEAD3/TMC1/KRAS	1.9902332844441
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	11/671	83/9376	1.85186648232273	CCL4/PCBP1/ADAR/CCL5/CCL4L2/ZDHHC1/DDX41/POLR1C/IL1B/POLR3C/ZCCHC3	2.16418866924403
Human Diseases	Cancer: specific types	hsa05218	Melanoma	10/671	73/9376	1.91413347487904	PIK3R1/PDGFRB/CDK6/AKT3/MITF/AKT1/IGF1R/AKT2/BRAF/KRAS	2.17681761386972
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	7/671	44/9376	2.22300501287088	CREB3L2/ADCY3/RAB11A/CREB3L1/DCTN5/CREB3L4/PRKACA	2.25751019807966
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	17/671	148/9376	1.60502678535465	PIK3R1/CDK6/AKT3/FOS/NCOA1/TCF7L2/CSNK1A1/SOS1/AKT1/CTNNB1/IGF1R/FZD1/DVL3/ESR1/AKT2/BRAF/KRAS	2.05974841442117
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	8/671	54/9376	2.07009990616548	HLA-C/HLA-A/GZMB/HLA-DPB1/HLA-F/HLA-B/HLA-DRA/HLA-DQA1	2.18942043441072
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	14/671	116/9376	1.68641759597102	CTNNA2/CTNNA3/PIK3R1/PTK2/CXCR4/PRKCA/MMP2/GNAI1/CTNNA1/ITGB2/CTNNB1/CLDN7/RAC2/RHOH	2.06525850697959
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	23/671	217/9376	1.4810276978442	CREB3L2/PIK3R1/AKT3/FOS/GSTT2B/MGST1/ADCY3/PRKCA/SOS1/KPNB1/GNAI1/AKT1/CREB3L1/ATF2/GSTA4/GSTO2/CREB3L4/PPARA/ESR1/AKT2/PRKACA/KRAS/ARRB1	1.99039115000746
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	17/671	149/9376	1.59425479350664	MT-ND3/MAPK10/GNAQ/GRIA1/GABRA2/PLCB1/ADCY3/GNB2/ITPR2/PRKCA/GNB1/GNAI1/PLCB3/GRIA3/PLCB4/ABHD6/PRKACA	2.03000953623342
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	17/671	150/9376	1.58362642821659	CTNNA2/CTNNA3/PIK3R1/AKT3/TCF7L2/CSNK1A1/SOS1/CTNNA1/AKT1/SMAD3/SMAD2/CTNNB1/FZD1/DVL3/AKT2/BRAF/KRAS	2.00048990736651
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	10/671	75/9376	1.86308991554893	PIK3R1/AKT3/BIRC3/GSTT2B/MGST1/AKT1/GSTA4/GSTO2/AKT2/BIRC2	2.08345614019599
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	20/671	187/9376	1.49445715150984	OAS2/STAT1/OAS1/OAS3/IRF9/BIRC3/MAPK10/CCL5/PLCB1/ITPR2/TAB2/PLCB3/PLCB4/ERBIN/TRAF6/GBP1/IL1B/GBP4/RBCK1/BIRC2	1.89617253027885
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	12/671	98/9376	1.71100094285106	DGKB/PIK3R1/INPP4B/PLCB1/PIP5K1B/ITPR2/PRKCA/IP6K2/PLCB3/IPPK/PLCB4/OCRL	1.96434850631021
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	12/671	98/9376	1.71100094285106	MARCKS/PLPP3/PIK3R1/AKT3/PTPRC/PIP5K1B/PRKCA/AKT1/RAC2/ACTR2/LYN/AKT2	1.96434850631021
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	13/671	110/9376	1.65137515241837	PIK3R1/AKT3/MAPK10/ADCY3/GNAI1/AKT1/IGF1R/CDC23/SPDYE1/AKT2/PRKACA/BRAF/KRAS	1.90784853547857
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	4/671	20/9376	2.7946348733234	LSS/LBR/SC5D/FDFT1	2.2305322380988
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	10/671	78/9376	1.79143261110474	INPP4B/PLCB1/PIP5K1B/IP6K2/ALDH6A1/PLCB3/IPPK/PLCB4/INPP5K/OCRL	1.94862819642506
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	10/671	78/9376	1.79143261110474	STAT1/FOS/IFNG/HLA-DPB1/HLA-DRA/TAB2/ITGB2/TRAF6/HLA-DQA1/IL1B	1.94862819642506
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	6/671	38/9376	2.20629068946584	ENPP1/NNMT/NAPRT/SIRT5/NADK2/NT5E	2.06861347747348
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	16/671	144/9376	1.55257492962411	TRA2A/AKT3/MAPK10/TCF7L2/TAB2/AKT1/SREBF1/CTNNB1/CPT1C/CAMKK2/TRAF6/IL1B/IL17RA/PPARA/ADH4/AKT2	1.85518419506632
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	9/671	68/9376	1.84939072499343	ZBTB16/PIK3R1/AKT3/TCF7L2/SOS1/AKT1/AKT2/BRAF/KRAS	1.95162464608947
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	12/671	100/9376	1.67678092399404	CCL4/CCL3/XCL2/XCL1/CCL3L1/CCL5/CCL4L2/CXCR4/IL2RB/IL20RA/IL2RG/TNFRSF10B	1.88899256947371
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	7/671	48/9376	2.03775459513164	PIK3R1/AKT3/PLCB1/AKT1/PLCB3/PLCB4/AKT2	2.00116788949806
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	25/671	250/9376	1.3973174366617	PSAP/MITF/CTSL/CTSW/ATP6V1G1/OSBPL5/ENTPD4/ARL8A/SNAPIN/AP1M1/AP5Z1/SLC15A4/GM2A/MANBA/VAMP7/SUMF1/SGSH/TFE3/OSBPL2/LAPTM5/SLC11A2/ACP5/CLTC/NAGA/VPS11	1.767786884952
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	8/671	59/9376	1.89466771072773	GSTT2B/MGST1/IDH1/GSTA4/RRM2B/LANCL1/GSTO2/PGD	1.91386910682905
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	8/671	59/9376	1.89466771072773	PIK3R1/AKT3/ADCY3/GNAI1/AKT1/NPR1/AKT2/PRKACA	1.91386910682905
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	18/671	169/9376	1.4882670923024	PIK3R1/AKT3/MAPK10/CTSL/RAB1A/ATG9A/AKT1/CAMKK2/HIF1A/IGF1R/WDFY3/TRAF6/SMCR8/PPP2CB/AKT2/PRKACA/KRAS/VPS11	1.77829679780355
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	10/671	80/9376	1.74664679582712	PIK3R1/PDGFRB/AKT3/PRKCA/SOS1/AKT1/IGF1R/AKT2/BRAF/KRAS	1.86197845837365
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	9/671	70/9376	1.79655098999361	AKT3/MAPK10/AKT1/CPT1C/CAMKK2/SLC2A1/ACSL5/PPARA/AKT2	1.85713548450086
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	7/671	50/9376	1.95624441132638	IFNG/LRP1/ITGB2/THBS3/IL1B/KLRK1/KLRB1	1.88221277673383
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	19/671	184/9376	1.44288213568328	PIK3R1/PPP3CA/PTK2/PARD3/PAK3/SRGAP3/CXCR4/PRKCA/GNAI1/PLXNC1/SEMA3C/CAMK2D/RAC2/NTNG1/EFNA5/EPHA6/BMPR1B/BMPR2/KRAS	1.6844362415963
Organismal Systems	Digestive system	hsa04978	Mineral absorption	8/671	61/9376	1.83254745791698	MT1E/TRPM6/MT2A/SLC8A1/CYBRD1/ATP2B4/MT1H/SLC11A2	1.81111070478993
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	15/671	138/9376	1.51882330071924	PIK3R1/AKT3/MAPK10/PPP1CB/SOS1/PTPRF/AKT1/SREBF1/PTPN1/PRKAR1A/AKT2/PRKACA/BRAF/KRAS/RHOQ	1.7046394976642
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	7/671	51/9376	1.91788667777096	SLC12A2/ADCY3/PRKCA/ATP6V1G1/KDELR2/PRKACA/ARF1	1.82478727981353
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	9/671	73/9376	1.72272012739114	PIK3R1/CDK6/AKT3/PRKCA/SOS1/AKT1/AKT2/BRAF/KRAS	1.72100677465221
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	10/671	85/9376	1.64390286666082	ENPP1/XDH/ENTPD4/GMPR/AMPD2/CANT1/CMPK2/RRM2B/NT5E/NT5C3A	1.65562166932358
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	13/671	120/9376	1.51376055638351	PIK3R1/AKT3/MAPK10/KIDINS220/SOS1/AKT1/CAMK2D/TRAF6/MAGED1/NTRK3/AKT2/BRAF/KRAS	1.57254187542766
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	6/671	44/9376	1.90543286817504	MAN1A1/ALG11/TMEM258/MGAT4B/STT3B/ALG9	1.67131280090466
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	14/671	133/9376	1.47086045964389	PIK3R1/AKT3/MAPK10/SOS1/AKT1/SMAD3/CREBBP/KLF2/FBXO25/SKP2/IGF1R/AKT2/BRAF/KRAS	1.51835763195116
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	12/671	110/9376	1.52434629454004	PIK3R1/AKT3/IFNG/PRKCA/AKT1/CREBBP/CAMK2D/HIF1A/IGF1R/RBX1/SLC2A1/AKT2	1.53578672199533
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	16/671	157/9376	1.42401776984632	ZFP36L1/PIK3R1/CDK6/AKT3/PPP3CA/HLA-C/PPP1CB/HLA-A/ITPR2/HLA-F/HLA-B/AKT1/SMAD3/SMAD2/AKT2/KRAS	1.48749147966565
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	18/671	181/9376	1.38959745082379	STAT1/AKT3/MAPK10/PPP3CA/CD74/IFNG/HLA-DPB1/HLA-DRA/BCL10/AKT1/CREBBP/ITGB2/CAMK2D/FCER1G/TRAF6/HLA-DQA1/IL1B/AKT2	1.46940677456443
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	9/671	77/9376	1.63322817272147	PIK3R1/CDK6/AKT3/SOS1/AKT1/SMAD3/AKT2/BRAF/KRAS	1.54899486461385
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	24/671	254/9376	1.32029994015279	EDNRA/PDGFRB/GNAQ/PPP3CA/ERBB4/SLC8A1/PLCB1/ADCY3/STIM1/ITPR2/CXCR4/PRKCA/ATP2B4/CAMK2D/PLCB3/RYR2/LHCGR/PLCB4/PPIF/P2RX4/HTR2A/NTRK3/PRKACA/MYLK3	1.43678303852846
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	14/671	138/9376	1.41756841400462	YWHAZ/PPP3CA/PPP1CB/ADCY3/ITPR2/PPP2R1A/CAMK2D/PPP2R5E/IGF1R/CDC23/RBX1/SPDYE1/PPP2CB/PRKACA	1.37195767904509
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	17/671	174/9376	1.36519519673844	MAPK10/MAN1A1/SEC31A/UBE2D3/SYVN1/MOGS/UBQLN2/SEC24C/PRKN/EDEM2/TMEM258/MBTPS2/RBX1/DDIT3/HSPA1A/ERO1B/STT3B	1.34996054931246
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	7/671	59/9376	1.65783424688676	ENPP1/ENTPD4/CANT1/CMPK2/RRM2B/NT5E/NT5C3A	1.4072360357195
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	21/671	227/9376	1.29267251849761	MT-ND3/MT-CO3/PIK3R1/AKT3/MAPK10/FOS/PTK2/GSTT2B/MGST1/SOS1/AKT1/HIF1A/PTPRJ/PTPN1/GSTA4/PPIF/GSTO2/NQO1/AKT2/BRAF/KRAS	1.23928322218235
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	6/671	49/9376	1.71100094285106	CREB3L2/GNAI1/CREB3L1/ATF2/CREB3L4/PRKACA	1.38535073300587
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	23/671	253/9376	1.27028857878336	PIK3R1/AKT3/MAPK10/PTK2/CCL5/SEPTIN2/PLCB1/ITPR2/ELMO1/BCL10/UBE2D3/TAB2/AKT1/PLCB3/ACTR2/PFN2/PLCB4/RBX1/TRAF6/IL1B/AKT2/RBCK1/ARF1	1.20998957461266
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	5/671	39/9376	1.79143261110474	MTHFD2/CHDH/MTHFD1/AHCYL2/ALDH1L1	1.37500752880994
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	6/671	50/9376	1.67678092399404	IL15/CXCR4/HLA-DPB1/HLA-DRA/PIGR/HLA-DQA1	1.3321340099906
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	16/671	168/9376	1.33077851110638	STAT1/EIF2AK2/IRF9/BIRC3/MAPK10/IFNG/CHMP1B/CAMK2D/STAT4/CHMP2B/TNFRSF10B/IL1B/GLUL/USP21/RBCK1/BIRC2	1.20107958195892
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	4/671	29/9376	1.92733439539545	STK3/LIMD1/MOB1A/TEAD3	1.38855074721435
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	6/671	52/9376	1.61228934999427	APOE/LIPG/ABCA1/LRP1/OSBPL5/APOC1	1.22919208600474
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	33/671	388/9376	1.18844008788237	MT-ND3/MT-CO3/APOE/EIF2AK2/TUBB/MME/PIK3R1/DKK1/AKT3/MAPK10/GNAQ/PPP3CA/PLCB1/APP/ITPR2/CSNK1A1/SLC39A14/AKT1/LRP1/CTNNB1/PLCB3/FZD1/PLCB4/DVL3/DDIT3/PPIF/IL1B/APBB1/SLC11A2/DKK2/AKT2/BRAF/KRAS	1.05249523808625
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	9/671	89/9376	1.41301763257925	PLCL1/GABRA2/ADCY3/GNB2/PRKCA/GNB1/GNAI1/GLUL/PRKACA	1.08689698511649
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	21/671	238/9376	1.23292714999562	ISG15/MX1/OAS2/STAT1/OAS1/EIF2AK2/OAS3/IRF9/C1S/PIK3R1/MX2/MAPK10/ADAR/IFIH1/FOS/RPS29/PRKCA/TAB2/TRAF6/C7/IL1B	1.01052142328031
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	3/671	21/9376	1.99616776665957	BCAT1/ENPP1/AASDHPPT	1.26876954948564
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	5/671	43/9376	1.62478771704849	GCDH/CPT1C/ACSL5/ACADSB/ADH4	1.14003605968036
Human Diseases	Immune disease	hsa05310	Asthma	4/671	32/9376	1.74664679582712	HLA-DPB1/HLA-DRA/FCER1G/HLA-DQA1	1.17458997680129
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	8/671	78/9376	1.43314608888379	SERPING1/C1S/MAPK10/FOS/GNAI1/ITGB2/TRAF6/IL1B	1.06647195241553
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	6/671	55/9376	1.52434629454004	PSAP/PLPP3/CERS5/SGPP1/GM2A/B4GALT6	1.08275651252486
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	10/671	103/9376	1.35661887054534	PPP1CB/PPP2R1A/FUS/NXT1/CSTF2/PPP2R5E/CPSF1/PPP2R3C/PPP2CB/NXF1	1.01035806671751
Human Diseases	Substance dependence	hsa05032	Morphine addiction	9/671	91/9376	1.38196229999509	GABRA2/ADCY3/GNB2/PRKCA/GNB1/GNAI1/PRKACA/PDE8A/ARRB1	1.01651256780372
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	12/671	128/9376	1.30998509687034	ENPP1/XDH/ADCY3/ENTPD4/GMPR/AMPD2/CANT1/RRM2B/NPR1/NT5E/PDE8A/NPR2	0.980357328396643
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	6/671	56/9376	1.49712582499468	RAB1A/ITGB2/IL1B/HSPA1A/RAB1B/ARF1	1.03589298628238
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	11/671	117/9376	1.31371724814348	ARID1B/BAZ2B/CHD4/VPS72/SMARCA2/BPTF/PBRM1/EPC1/BRD9/ACTR5/BCL7B	0.948007550218375
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	10/671	105/9376	1.33077851110638	MAPK10/MITF/ATG9A/FUNDC1/PRKN/HIF1A/RHOT1/TFE3/TOMM70/KRAS	0.946305049683057
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	14/671	155/9376	1.26209316859766	TUBB/HLA-C/HLA-A/CTSL/HLA-DPB1/HLA-F/HLA-B/HLA-DRA/ATP6V1G1/ITGB2/THBS3/HGS/TAP1/HLA-DQA1	0.913471600693935
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	6/671	57/9376	1.47086045964389	ELOVL5/FADS2/CPT1C/ACSL5/ACADSB/HACD3	0.989936881389901
NA	NA	hsa04081	Hormone signaling	19/671	219/9376	1.21228453409006	PRLR/PIK3R1/GNAQ/PLCB1/ADCY3/GNB2/NPR3/GNB1/GNAI1/PLCB3/BMPR1B/IGF1R/LHCGR/PLCB4/NPR1/BMPR1A/ESR1/PRKACA/NPR2	0.882523575499125
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	3/671	23/9376	1.82258796086309	POMGNT1/LARGE1/B3GALNT2	1.09656229932234
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	10/671	108/9376	1.29381244135342	KPNB1/NXT1/NUP62/NUP37/NMD3/NUP153/NUP88/NXF1/NUP50/XPO1	0.852612229302732
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	3/671	24/9376	1.74664679582712	XYLT1/HS2ST1/HS6ST1	1.01678958255312
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	7/671	72/9376	1.3585030634211	ISG15/MAPK10/ADAR/IFIH1/RNF125/TRAF6/OTUD5	0.847787051145105
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	4/671	37/9376	1.51061344503967	TCF7L2/CTNNB1/BRAF/KRAS	0.863983464988567
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/671	27/9376	1.55257492962411	ELOVL5/FADS2/HACD3	0.798275847985952
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	8/671	89/9376	1.25601567340377	COL1A1/COL6A1/COL1A2/COL6A3/LAMA2/ITGB8/FRAS1/THBS3	0.67373071175536
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	6/671	65/9376	1.28983147999541	LIPG/DGKB/PLPP3/ABHD16A/DGAT1/MBOAT2	0.650978402267568
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	13/671	157/9376	1.15701443800013	PBX1/ABCA1/PTK2/MEGF10/ELMO1/LRP1/CPT1C/CAMK2D/HIF1A/TGFBRAP1/MERTK/SLC2A1/VPS11	0.550820402631569
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	9/671	105/9376	1.19770065999574	CCL4/BIRC3/CCL4L2/BCL10/TAB2/TRAF6/IL1B/LYN/BIRC2	0.565590347008595
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	9/671	105/9376	1.19770065999574	LAMA2/ITGB8/SLC8A1/ADCY3/RYR2/CACNA2D1/TTN/SNTB1/PRKACA	0.565590347008595
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	37/671	480/9376	1.07709885742673	MT-ND3/MT-CO3/ATXN1/TUBB/DKK1/MAPK10/GNAQ/SNCAIP/PPP3CA/GRIA1/PLCB1/APP/ITPR2/CSNK1A1/FUS/PRKCA/RAB1A/CTNNB1/CAMK2D/PLCB3/GRIA3/PRKN/CCS/RYR2/FZD1/PLCB4/DVL3/CHMP2B/DDIT3/PPIF/ATXN2/DCTN5/IL1B/DKK2/SMCR8/BRAF/KRAS	0.481430592619276
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	13/671	158/9376	1.14969156181026	PIK3R1/AKT3/PRKCA/SOS1/AKT1/ATP6V1G1/SKP2/IGF1R/FZD1/DVL3/AKT2/BRAF/KRAS	0.526829422766029
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	19/671	238/9376	1.1155055166627	PIK3R1/PDGFRB/AKT3/MAPK10/GNB2/PAK3/PRKCA/SOS1/GNB1/AKT1/RAC2/EFNA5/IGF1R/RGL2/RASAL2/FLT3LG/AKT2/PRKACA/KRAS	0.501104311356217
NA	NA	hsa04082	Neuroactive ligand signaling	16/671	199/9376	1.12347130585865	GNAQ/P2RY14/GRIA1/GABRA2/PLCB1/ADCY3/GNB2/PRKCA/GNB1/GNAI1/PLCB3/GRIA3/PLCB4/P2RX4/HTR2A/PRKACA	0.488770205491378
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	4/671	42/9376	1.33077851110638	PCBP1/SLC39A14/SLC11A2/ACSL5	0.596472664709075
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	6/671	68/9376	1.23292714999562	ALDH1A2/ALDH1A3/CYP26A1/DGAT1/ADH4/DHRS4	0.535191112050751
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	7/671	82/9376	1.19283195812584	XDH/GSTT2B/MGST1/TPMT/GSTA4/RRM2B/GSTO2	0.486908228572043
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	5/671	56/9376	1.24760485416223	CSNK1A1/GPR161/HHIP/PRKACA/ARRB1	0.515950125501675
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	2/671	18/9376	1.55257492962411	MANBA/ENGASE	0.651475997813812
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	23/671	298/9376	1.07846647796037	CCL4/PRLR/CCL3/XCL2/XCL1/CCL3L1/CCL5/IL15/CCL4L2/BMP8A/IFNG/CXCR4/IL2RB/IL20RA/IL2RG/BMPR1B/IL7/TNFRSF10B/IL1B/BMPR2/IL17RA/BMPR1A/LIFR	0.382172745897808
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	4/671	44/9376	1.27028857878336	TAF6/TAF9B/ERCC3/TAF8	0.49891800655466
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	4/671	44/9376	1.27028857878336	PARP2/OGG1/MUTYH/POLB	0.49891800655466
Human Diseases	Substance dependence	hsa05034	Alcoholism	15/671	191/9376	1.09736971465578	CREB3L2/PPP1CB/GNB2/SOS1/GNB1/GNAI1/CAMKK2/CREB3L1/HDAC9/ATF2/CREB3L4/PRKACA/BRAF/KRAS/CAMKK1	0.377453547249777
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	4/671	45/9376	1.24205994369929	ABCA1/ABCG2/TAP1/ABCC9	0.451884662040162
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	3/671	32/9376	1.30998509687034	BIRC3/MAPK10/BIRC2	0.487654122105126
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	21/671	275/9376	1.06704240617802	MT-ND3/MT-CO3/CREB3L2/TUBB/PIK3R1/MAPK10/PPP3CA/CCL5/ITPR2/NCAM1/RAC2/CREB3L1/ATF2/RYR2/DDIT3/PPIF/C7/IL1B/HSPA1A/CREB3L4/PRKACA	0.313280882264507
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	18/671	235/9376	1.07028569616641	MT-ND3/MT-CO3/ZNF516/ARID1B/CREB3L2/ADCY3/BMP8A/SOS1/SMARCA2/CPT1C/CREB3L1/ATF2/ACSL5/NPR1/CREB3L4/COX15/PRKACA/KRAS	0.302946917590353
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/671	20/9376	1.3973174366617	NANP/GNE	0.493821536851967
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	3/671	34/9376	1.23292714999562	POLR1C/POLR3C/POLR2J3	0.37774797985214
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	12/671	157/9376	1.06801332738474	MT-CO3/PIK3R1/AKT3/MAPK10/FOS/ITCH/AKT1/SREBF1/DDIT3/IL1B/PPARA/AKT2	0.238596710286875
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	4/671	48/9376	1.16443119721808	BCAT1/ALDH6A1/ACAD8/ACADSB	0.317083088283321
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	15/671	200/9376	1.04798807749627	TUBB/MAPK10/FOS/PAK3/BAIAP2/RAB1A/TAB2/CLDN7/MYH9/ACTR2/SEC24C/TRAF6/TNFRSF10B/IL1B/ARF1	0.190451394729424
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	8/671	104/9376	1.07485956666285	DGKB/PLPP3/GPCPD1/GNPAT/PCYT1A/CEPT1/LYPLA2/MBOAT2	0.213127640774166
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	5/671	63/9376	1.10898209258865	TCF7L2/CTNNB1/FZD1/DVL3/HHIP	0.24095898572493
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	6/671	78/9376	1.07485956666285	PAN3/EXOSC7/CNOT3/CNOT7/CNOT8/TOB2	0.184315708406001
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	3/671	37/9376	1.13296008377976	NANP/GALT/GNE	0.224975105934153
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	6/671	79/9376	1.06125374936332	GSTT2B/MGST1/GSTA4/CBR3/GSTO2/ADH4	0.151787957803315
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	7/671	94/9376	1.04055553793956	MAPK10/FOS/IFNG/TAB2/TRAF6/IL1B/IL17RA	0.109712426821726
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	4/671	52/9376	1.07485956666285	ADCY3/IGF1R/LHCGR/PRKACA	0.150283173967626
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/671	38/9376	1.10314534473292	PIK3R1/PRKCA/KRAS	0.176879297930791
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	3/671	38/9376	1.10314534473292	PTPRC/IL2RG/TAP1	0.176879297930791
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	7/671	99/9376	0.988002227942615	LAMA2/ITGB8/SLC8A1/RYR2/CACNA2D1/TTN/SNTB1	-0.0333178475113002
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	3/671	41/9376	1.02242739267929	RAD51B/RPA3/SYCP3	0.0399554535538884
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	3/671	41/9376	1.02242739267929	GRIA1/GABRA2/GRIA3	0.0399554535538884
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	3/671	41/9376	1.02242739267929	MMP2/BRAF/KRAS	0.0399554535538884
Genetic Information Processing	Transcription	hsa03040	Spliceosome	17/671	243/9376	0.977547177911477	PCBP1/TRA2A/SRSF7/DDX5/SF1/FUS/HNRNPK/SF3B4/CHERP/USP39/PRPF38A/RBMXL1/U2AF2/HSPA1A/BUD13/PRPF18/PRPF40A	-0.0984532038940847
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	7/671	100/9376	0.978122205663189	MME/HLA-DPB1/HLA-DRA/IL7/HLA-DQA1/IL1B/FLT3LG	-0.061064059983868
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	5/671	71/9376	0.984026363846267	MAPK10/CCL5/ATP6V1G1/CSK/LYN	-0.0375091553039482
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/671	12/9376	1.16443119721808	NQO1	0.158236493319815
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/671	12/9376	1.16443119721808	NCAM1	0.158236493319815
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	3/671	43/9376	0.974872630229092	ABCA1/PLPP3/DGAT1	-0.0458493450528796
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/671	28/9376	0.998083883329785	ELOVL5/HACD3	-0.00281905872946356
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5/671	73/9376	0.95706673743952	GSTT2B/MGST1/GSTA4/GSTO2/ADH4	-0.102236582217836
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	6/671	88/9376	0.952716434087522	SERPING1/C1S/TFPI/ITGB2/PLAUR/C7	-0.123723718701973
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/671	13/9376	1.07485956666285	LIG4	0.0749849288660407
Organismal Systems	Digestive system	hsa04976	Bile secretion	6/671	90/9376	0.931544957774466	SCTR/ADCY3/ABCG2/SLC2A1/SLC4A2/PRKACA	-0.181165237757892
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	25/671	368/9376	0.949264562949524	MT-ND3/MT-CO3/TUBB/SRSF7/PPP3CA/GRIA1/ERBB4/FUS/RAB1A/NXT1/NUP62/UBQLN2/PRKN/NUP37/CCS/PFN2/CHMP2B/DDIT3/ATXN2/DCTN5/SMCR8/NUP153/NUP88/NXF1/NUP50	-0.275666274507752
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/671	30/9376	0.931544957774466	ABCG2/IL1B	-0.104259513063861
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/671	31/9376	0.901495120426902	RPIA/PGD	-0.152514610172134
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	2/671	31/9376	0.901495120426902	ACSS1/GLUL	-0.152514610172134
NA	NA	hsa04981	Folate transport and metabolism	2/671	31/9376	0.901495120426902	ABCG2/MTHFD1	-0.152514610172134
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	4/671	63/9376	0.88718567407092	RPA3/RBX1/ERCC3/POLR2J3	-0.249432038837028
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	10/671	154/9376	0.907348984845259	BCAT1/MTHFD2/PDXP/NAPRT/CMPK2/MTHFD1/FECH/COX15/NADK2/NQO1	-0.321855173354889
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/671	15/9376	0.931544957774466	ST6GALNAC5	-0.0736635187172184
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/671	32/9376	0.873323397913562	ALDH6A1/ACSS1	-0.199281732591037
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	2/671	32/9376	0.873323397913562	ATG9A/PPP2CB	-0.199281732591037
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	3/671	49/9376	0.85550047142553	GXYLT2/POFUT2/GALNT2	-0.281550298691487
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	2/671	33/9376	0.846859052522242	BCAT1/IDH1	-0.24466262770939
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/671	16/9376	0.873323397913562	NAGA	-0.140792974109559
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/671	17/9376	0.821951433330411	ACOT8	-0.203990869662881
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/671	17/9376	0.821951433330411	KYAT3	-0.203990869662881
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/671	17/9376	0.821951433330411	GLUL	-0.203990869662881
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	6/671	99/9376	0.846859052522242	C1S/KRT18/HLA-DPB1/HLA-DRA/ITGB2/HLA-DQA1	-0.425272851609104
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/671	18/9376	0.776287464812055	ACSL5	-0.263753093511076
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/671	36/9376	0.776287464812055	ENPP1/TREH	-0.373362453884364
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	2/671	36/9376	0.776287464812055	RPA3/MCM7	-0.373362453884364
Organismal Systems	Sensory system	hsa04742	Taste transduction	5/671	86/9376	0.812393858524244	GABRA2/PLCB1/PLCB3/PLCB4/PRKACA	-0.485233672141891
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/671	70/9376	0.798467106663828	GSTT2B/MGST1/GSTA4/GSTO2	-0.469868084040338
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	12/671	195/9376	0.859887653330276	PIK3R1/AKT3/PLCB1/PRKCA/AKT1/ITGB2/RAC2/PLCB3/HDAC9/PLCB4/PPIF/AKT2	-0.54892274879093
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	3/671	54/9376	0.776287464812055	BCAT1/KYAT3/AHCYL2	-0.457715016282387
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/671	19/9376	0.735430229821947	SGSH	-0.320487589292589
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	2/671	38/9376	0.735430229821947	GALT/GNE	-0.453698761916773
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	19/671	308/9376	0.861981535602996	MT-ND3/MT-CO3/TGM2/CREB3L2/TUBB/MAPK10/GNAQ/GRIA1/PLCB1/CREBBP/PLCB3/GRIA3/CREB3L1/PLCB4/PPIF/DCTN5/CREB3L4/CLTC/POLR2J3	-0.683784582163883
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	10/671	170/9376	0.821951433330411	MAPK10/PARD3/PPP2R1A/CLDN7/MYH9/ACTR2/PPP2CB/RAB8B/PRKACA/RAPGEF2	-0.650414130380686
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	4/671	75/9376	0.745235966219573	BCAT1/IDH1/RPIA/GLUL	-0.614987709760626
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	4/671	75/9376	0.745235966219573	CDK6/RRM2B/TNFRSF10B/SHISA5	-0.614987709760626
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	4/671	76/9376	0.735430229821947	FADS2/CPT1C/ACSL5/PPARA	-0.642936456764615
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/671	42/9376	0.66538925555319	GCDH/KYAT3	-0.603383096782512
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/671	23/9376	0.607529320287695	GLUL	-0.523188487356865
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/671	23/9376	0.607529320287695	RPA3	-0.523188487356865
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/671	23/9376	0.607529320287695	MME	-0.523188487356865
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/671	46/9376	0.607529320287695	FECH/COX15	-0.740811681662212
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	2/671	46/9376	0.607529320287695	PSMB9/IFNG	-0.740811681662212
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/671	26/9376	0.537429783331423	FADS2	-0.655723948999094
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/671	26/9376	0.537429783331423	BTD	-0.655723948999094
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	2/671	47/9376	0.594603164536893	ACSS1/ADH4	-0.773524809011176
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	2/671	47/9376	0.594603164536893	PIK3R1/MAPK10	-0.773524809011176
NA	NA	hsa03272	Virion - Hepatitis viruses	2/671	48/9376	0.582215598609041	CHMP1B/CLDN7	-0.805640112526505
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	15/671	268/9376	0.782080654847966	MT-ND3/MT-CO3/TUBB/MAPK10/SNCAIP/ITPR2/SLC39A14/GNAI1/CAMK2D/PRKN/DUSP1/DDIT3/PPIF/SLC11A2/PRKACA	-1.00487995181877
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/671	28/9376	0.499041941664892	ST3GAL6	-0.737027243380845
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/671	28/9376	0.499041941664892	ATP6V1G1	-0.737027243380845
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	4/671	87/9376	0.642444798465149	MT-CO3/SLC8A1/RYR2/CACNA2D1	-0.9302094683208
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/671	29/9376	0.481833598848862	GNB1	-0.775880143206554
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/671	51/9376	0.547967622220274	PLPP3/CEPT1	-0.898654434161139
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/671	30/9376	0.465772478887233	IDH1	-0.813647898032481
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/671	30/9376	0.465772478887233	PIGN	-0.813647898032481
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/671	31/9376	0.450747560213451	ALDH6A1	-0.850404793175514
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/671	31/9376	0.450747560213451	GET1	-0.850404793175514
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	2/671	54/9376	0.51752497654137	RPA3/FANCM	-0.987142106421008
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/671	32/9376	0.436661698956781	GALT	-0.886217587287201
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/671	33/9376	0.423429526261121	VAMP7	-0.921146496008782
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/671	34/9376	0.410975716665206	RBX1	-0.955246020559477
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	5/671	116/9376	0.602291998561077	IDH1/ALDH6A1/RPIA/ACSS1/PGD	-1.19660369735083
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/671	36/9376	0.388143732406028	GALNT2	-1.02115045677478
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/671	37/9376	0.377653361259919	GLUL	-1.05304161217467
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/671	37/9376	0.377653361259919	ADH4	-1.05304161217467
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	6/671	143/9376	0.586287036361552	C1S/IFNG/HLA-DPB1/HLA-DRA/HLA-DQA1/C7	-1.3840705922911
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/671	41/9376	0.340809130893097	CHDH	-1.17437949789265
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	2/671	67/9376	0.417109682585582	ACSS1/ADH4	-1.32933744414799
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	16/671	323/9376	0.692169628067715	MARCKS/MMP16/PIK3R1/PDGFRB/CDK6/ZFPM2/HOXD10/PRKCA/SOS1/HNRNPK/CREBBP/EFNA5/ZEB2/BMPR2/SPRY2/KRAS	-1.56307198255412
Cellular Processes	Cell motility	hsa04814	Motor proteins	8/671	194/9376	0.576213375942969	TUBB/KIF26B/CAPZA1/MYH9/KIF13A/DCTN5/KIF21A/HOOK3	-1.65593000798789
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/671	50/9376	0.27946348733234	OAT	-1.41825982372557
NA	NA	hsa04382	Cornified envelope formation	9/671	217/9376	0.579532577417295	S100A6/KRT18/PPP2R1A/PKP2/CLDN7/PPP2R5E/PPP2R3C/S100A4/PPP2CB	-1.73980550501716
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	2/671	79/9376	0.353751249787772	ATP6V1G1/CLTC	-1.60141671403393
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/671	63/9376	0.22179641851773	CBR3	-1.7206051125229
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	4/671	138/9376	0.405019546858463	MT-ND3/MT-CO3/ATP6V1G1/COX15	-1.95486050714607
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	6/671	183/9376	0.458136864479246	NXT1/NMD3/WDR3/EFL1/NXF1/XPO1	-2.05517605409902
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	15/671	370/9376	0.566480041889878	EDNRA/SCTR/CALCRL/PRLR/GZMA/P2RY14/GRIA1/GABRA2/GRIA3/LHCGR/NR3C1/LPAR3/S1PR2/P2RX4/HTR2A	-2.3621446959828
Genetic Information Processing	Translation	hsa03010	Ribosome	3/671	222/9376	0.188826680629959	RPS29/MRPL30/MRPL21	-3.39583985750096
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	7/671	449/9376	0.217844589234563	SLC8A1/ADCY3/GNB1/RGS2/CAMK2D/PRKACA/ARRB1	-4.71548065656732