ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003712 transcription coregulator activity 78/1291 495/18639 0.157575757575758 2.27502288571227 5.74599036103394e-12 6.72280872240971e-09 GO:0003713 transcription coactivator activity 43/1291 256/18639 0.16796875 2.42507322327653 5.31154643445653e-08 3.10725466415707e-05 GO:0003714 transcription corepressor activity 34/1291 204/18639 0.166666666666667 2.40627420604183 1.54486346302015e-06 0.000602496750577857 GO:0046332 SMAD binding 18/1291 79/18639 0.227848101265823 3.28959005382933 5.70416185809071e-06 0.00166846734349153 GO:0001221 transcription coregulator binding 21/1291 115/18639 0.182608695652174 2.63643956488061 3.7462968904612e-05 0.00876633472367921 GO:0140297 DNA-binding transcription factor binding 57/1291 488/18639 0.116803278688525 1.68636430013587 7.31418170481684e-05 0.014166223475162 GO:0016763 pentosyltransferase activity 12/1291 49/18639 0.244897959183673 3.53574985377575 9.68109490265084e-05 0.014166223475162 GO:0042393 histone binding 34/1291 247/18639 0.137651821862348 1.9873681701722 9.6863066496834e-05 0.014166223475162 GO:0004842 ubiquitin-protein transferase activity 52/1291 449/18639 0.115812917594655 1.67206581800679 0.000184362708472431 0.0239671521014161 GO:0061630 ubiquitin protein ligase activity 42/1291 353/18639 0.118980169971671 1.71779348419983 0.000423822330371959 0.0400371198872171 GO:0001222 transcription corepressor binding 11/1291 49/18639 0.224489795918367 3.24110403262777 0.000425396129587422 0.0400371198872171 GO:0019787 ubiquitin-like protein transferase activity 53/1291 479/18639 0.110647181628392 1.59748475474176 0.000490706205176902 0.0400371198872171 GO:0035252 UDP-xylosyltransferase activity 5/1291 11/18639 0.454545454545455 6.56256601647771 0.000513296408810476 0.0400371198872171 GO:0042285 xylosyltransferase activity 5/1291 11/18639 0.454545454545455 6.56256601647771 0.000513296408810476 0.0400371198872171 GO:0048407 platelet-derived growth factor binding 5/1291 11/18639 0.454545454545455 6.56256601647771 0.000513296408810476 0.0400371198872171 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 53/1291 484/18639 0.109504132231405 1.58098181306054 0.000626438085984873 0.0433682438798544 GO:0016755 aminoacyltransferase activity 54/1291 496/18639 0.108870967741935 1.57184040878539 0.000641578129051631 0.0433682438798544 GO:0061659 ubiquitin-like protein ligase activity 43/1291 372/18639 0.115591397849462 1.66886759451288 0.000667203751997761 0.0433682438798544 GO:0003924 GTPase activity 39/1291 331/18639 0.117824773413897 1.7011122785915 0.00080653614738774 0.046406617992817 GO:0035497 cAMP response element binding 5/1291 12/18639 0.416666666666667 6.01568551510457 0.000829862333673646 0.046406617992817 GO:0042605 peptide antigen binding 10/1291 45/18639 0.222222222222222 3.20836560805577 0.000838171991249121 0.046406617992817 GO:0001216 DNA-binding transcription activator activity 53/1291 491/18639 0.107942973523422 1.55844235747719 0.000872603073369209 0.046406617992817 GO:0017124 SH3 domain binding 18/1291 115/18639 0.156521739130435 2.25980534132624 0.000919471232408229 0.046526807240817 GO:0008013 beta-catenin binding 17/1291 106/18639 0.160377358490566 2.31547140581383 0.000954396045965477 0.046526807240817 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 40/1291 349/18639 0.114613180515759 1.65474443968492 0.00118691457285368 0.0555476020095523 GO:0003725 double-stranded RNA binding 13/1291 75/18639 0.173333333333333 2.5025251742835 0.00178742612905931 0.0804341758076691 GO:0005516 calmodulin binding 26/1291 207/18639 0.1256038647343 1.81342403933587 0.00234158668317884 0.101468756271083 GO:0030020 extracellular matrix structural constituent conferring tensile strength 9/1291 44/18639 0.204545454545455 2.95315470741497 0.00277935982664997 0.116137535613588 GO:0017046 peptide hormone binding 10/1291 53/18639 0.188679245283019 2.72408400683981 0.00309586403574793 0.124902100752589 GO:0141109 transporter activator activity 4/1291 10/18639 0.4 5.77505809450039 0.00342909285851437 0.133734621482061 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 6/1291 23/18639 0.260869565217391 3.76634223554373 0.0039585528980101 0.140348693656722 GO:0005158 insulin receptor binding 6/1291 23/18639 0.260869565217391 3.76634223554373 0.0039585528980101 0.140348693656722 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 6/1291 23/18639 0.260869565217391 3.76634223554373 0.0039585528980101 0.140348693656722 GO:0042277 peptide binding 29/1291 249/18639 0.116465863453815 1.68149281867983 0.00418617424395545 0.14405364310082 GO:0070325 lipoprotein particle receptor binding 7/1291 31/18639 0.225806451612903 3.26011344044377 0.00453645371892317 0.151647167175432 GO:0140537 transcription regulator activator activity 4/1291 11/18639 0.363636363636364 5.25005281318217 0.00509526225834517 0.165596023396218 GO:0019207 kinase regulator activity 32/1291 287/18639 0.111498257839721 1.60977229114993 0.00528248765824499 0.167040825949909 GO:0045296 cadherin binding 36/1291 334/18639 0.107784431137725 1.55615337875759 0.00557936519006645 0.171785717694151 GO:0070064 proline-rich region binding 5/1291 18/18639 0.277777777777778 4.01045701006971 0.00633178577478557 0.184173089116317 GO:0042578 phosphoric ester hydrolase activity 38/1291 363/18639 0.104683195592287 1.5113788401585 0.00721355608561762 0.184173089116317 GO:0070410 co-SMAD binding 4/1291 12/18639 0.333333333333333 4.81254841208366 0.00722796222068093 0.184173089116317 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 4/1291 12/18639 0.333333333333333 4.81254841208366 0.00722796222068093 0.184173089116317 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 4/1291 12/18639 0.333333333333333 4.81254841208366 0.00722796222068093 0.184173089116317 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 4/1291 12/18639 0.333333333333333 4.81254841208366 0.00722796222068093 0.184173089116317 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 4/1291 12/18639 0.333333333333333 4.81254841208366 0.00722796222068093 0.184173089116317 GO:0005096 GTPase activator activity 30/1291 271/18639 0.11070110701107 1.59826331028608 0.00746885898009465 0.184173089116317 GO:0004435 phosphatidylinositol phospholipase C activity 6/1291 26/18639 0.230769230769231 3.33176428528868 0.00755581904066942 0.184173089116317 GO:0050750 low-density lipoprotein particle receptor binding 6/1291 26/18639 0.230769230769231 3.33176428528868 0.00755581904066942 0.184173089116317 GO:0042800 histone H3K4 methyltransferase activity 5/1291 19/18639 0.263157894736842 3.7993803253292 0.00811069545759174 0.1932841058336 GO:0016791 phosphatase activity 30/1291 273/18639 0.10989010989011 1.58655442156604 0.00826000452280341 0.1932841058336 GO:0001223 transcription coactivator binding 8/1291 44/18639 0.181818181818182 2.62502640659109 0.00981295059034416 0.213960253071683 GO:0004535 poly(A)-specific ribonuclease activity 4/1291 13/18639 0.307692307692308 4.44235238038491 0.00987508860330845 0.213960253071683 GO:0046975 histone H3K36 methyltransferase activity 4/1291 13/18639 0.307692307692308 4.44235238038491 0.00987508860330845 0.213960253071683 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 4/1291 13/18639 0.307692307692308 4.44235238038491 0.00987508860330845 0.213960253071683 GO:0016004 phospholipase activator activity 5/1291 20/18639 0.25 3.60941130906274 0.0102083567121333 0.216785447701468 GO:0001217 DNA-binding transcription repressor activity 30/1291 278/18639 0.107913669064748 1.55801927009903 0.0105441525457536 0.216785447701468 GO:0019887 protein kinase regulator activity 28/1291 255/18639 0.109803921568627 1.58531006515697 0.0105613423239177 0.216785447701468 GO:0030165 PDZ domain binding 12/1291 83/18639 0.144578313253012 2.08737039560255 0.011615844041002 0.234319612551247 GO:0043394 proteoglycan binding 7/1291 37/18639 0.189189189189189 2.73144639604748 0.0123714051103185 0.242278642864694 GO:0005201 extracellular matrix structural constituent 20/1291 168/18639 0.119047619047619 1.71876729002988 0.012424545787933 0.242278642864694 GO:0042562 hormone binding 13/1291 94/18639 0.138297872340426 1.99669561777939 0.0126599858704994 0.242822679811219 GO:0004629 phospholipase C activity 6/1291 29/18639 0.206896551724138 2.98709901439675 0.0130585876855223 0.246428186968727 GO:0016922 nuclear receptor binding 17/1291 137/18639 0.124087591240876 1.79153262055669 0.0137860148795075 0.256025990619424 GO:0140938 histone H3 methyltransferase activity 8/1291 47/18639 0.170212765957447 2.45747152957463 0.0145038656707426 0.265148794293264 GO:0031624 ubiquitin conjugating enzyme binding 6/1291 30/18639 0.2 2.88752904725019 0.0153903927021291 0.272597310820483 GO:0008093 cytoskeletal anchor activity 5/1291 22/18639 0.227272727272727 3.28128300823886 0.0154563696399181 0.272597310820483 GO:0044389 ubiquitin-like protein ligase binding 33/1291 322/18639 0.102484472049689 1.47963444967789 0.0156102733546773 0.272597310820483 GO:0016500 protein-hormone receptor activity 10/1291 67/18639 0.149253731343284 2.15487242332104 0.016442355391048 0.278064476323749 GO:0042054 histone methyltransferase activity 10/1291 67/18639 0.149253731343284 2.15487242332104 0.016442355391048 0.278064476323749 GO:0140030 modification-dependent protein binding 20/1291 173/18639 0.115606936416185 1.6690919348267 0.0167245498046371 0.278064476323749 GO:0042809 nuclear vitamin D receptor binding 4/1291 15/18639 0.266666666666667 3.85003872966692 0.0168739981358856 0.278064476323749 GO:0008170 N-methyltransferase activity 13/1291 98/18639 0.13265306122449 1.91519783746186 0.0175339428773313 0.284926571756633 GO:1990841 promoter-specific chromatin binding 10/1291 68/18639 0.147058823529412 2.12318312297808 0.0181194011917592 0.28711503841874 GO:0019199 transmembrane receptor protein kinase activity 11/1291 78/18639 0.141025641025641 2.03607817434309 0.0182087653273227 0.28711503841874 GO:0016757 glycosyltransferase activity 28/1291 267/18639 0.104868913857678 1.51406017458812 0.018639686981624 0.28711503841874 GO:0070577 lysine-acetylated histone binding 5/1291 23/18639 0.217391304347826 3.13861852961978 0.0186502076237814 0.28711503841874 GO:0016279 protein-lysine N-methyltransferase activity 10/1291 69/18639 0.144927536231884 2.09241235307985 0.0199189412882759 0.302664432562114 GO:0005525 GTP binding 37/1291 378/18639 0.0978835978835979 1.41320866069123 0.0211836464197846 0.306255791005026 GO:0005024 transforming growth factor beta receptor activity 4/1291 16/18639 0.25 3.60941130906274 0.0212904300923152 0.306255791005026 GO:0034450 ubiquitin-ubiquitin ligase activity 4/1291 16/18639 0.25 3.60941130906274 0.0212904300923152 0.306255791005026 GO:0016278 lysine N-methyltransferase activity 10/1291 70/18639 0.142857142857143 2.06252074803585 0.0218456556683501 0.306255791005026 GO:0097110 scaffold protein binding 10/1291 70/18639 0.142857142857143 2.06252074803585 0.0218456556683501 0.306255791005026 GO:0035035 histone acetyltransferase binding 5/1291 24/18639 0.208333333333333 3.00784275755229 0.022249352337972 0.306255791005026 GO:0060229 lipase activator activity 5/1291 24/18639 0.208333333333333 3.00784275755229 0.022249352337972 0.306255791005026 GO:0140033 acetylation-dependent protein binding 5/1291 24/18639 0.208333333333333 3.00784275755229 0.022249352337972 0.306255791005026 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 12/1291 91/18639 0.131868131868132 1.90386530587925 0.0228823429416613 0.311306293508648 GO:0051879 Hsp90 protein binding 7/1291 42/18639 0.166666666666667 2.40627420604183 0.0240402296569982 0.314533548016246 GO:0071889 14-3-3 protein binding 6/1291 33/18639 0.181818181818182 2.62502640659109 0.0240769552516568 0.314533548016246 GO:0004674 protein serine/threonine kinase activity 41/1291 433/18639 0.0946882217090069 1.36707495308612 0.0259210960514418 0.314533548016246 GO:0016779 nucleotidyltransferase activity 16/1291 136/18639 0.117647058823529 1.69854649838247 0.0260420883116241 0.314533548016246 GO:0004029 aldehyde dehydrogenase (NAD+) activity 4/1291 17/18639 0.235294117647059 3.39709299676493 0.0263503941167292 0.314533548016246 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 4/1291 17/18639 0.235294117647059 3.39709299676493 0.0263503941167292 0.314533548016246 GO:0019198 transmembrane receptor protein phosphatase activity 4/1291 17/18639 0.235294117647059 3.39709299676493 0.0263503941167292 0.314533548016246 GO:0004712 protein serine/threonine/tyrosine kinase activity 7/1291 43/18639 0.162790697674419 2.35031434078504 0.0270553073307964 0.314533548016246 GO:0019209 kinase activator activity 17/1291 148/18639 0.114864864864865 1.65837816902883 0.0273873525132996 0.314533548016246 GO:0004382 GDP phosphatase activity 3/1291 10/18639 0.3 4.33129357087529 0.0275277494962845 0.314533548016246 GO:0005522 profilin binding 3/1291 10/18639 0.3 4.33129357087529 0.0275277494962845 0.314533548016246 GO:0008140 cAMP response element binding protein binding 3/1291 10/18639 0.3 4.33129357087529 0.0275277494962845 0.314533548016246 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 3/1291 10/18639 0.3 4.33129357087529 0.0275277494962845 0.314533548016246 GO:0140999 histone H3K4 trimethyltransferase activity 3/1291 10/18639 0.3 4.33129357087529 0.0275277494962845 0.314533548016246 GO:1990763 arrestin family protein binding 3/1291 10/18639 0.3 4.33129357087529 0.0275277494962845 0.314533548016246 GO:0035401 histone H3Y41 kinase activity 14/1291 115/18639 0.121739130434783 1.75762637658707 0.0276897055091225 0.314533548016246 GO:0140801 histone H2AXY142 kinase activity 14/1291 115/18639 0.121739130434783 1.75762637658707 0.0276897055091225 0.314533548016246 GO:0019001 guanyl nucleotide binding 38/1291 400/18639 0.095 1.37157629744384 0.0297285170279021 0.331133602690899 GO:0032561 guanyl ribonucleotide binding 38/1291 400/18639 0.095 1.37157629744384 0.0297285170279021 0.331133602690899 GO:0070412 R-SMAD binding 5/1291 26/18639 0.192307692307692 2.77647023774057 0.0307257000573365 0.331133602690899 GO:0000175 3'-5'-RNA exonuclease activity 6/1291 35/18639 0.171428571428571 2.47502489764302 0.0313974282457679 0.331133602690899 GO:0003925 G protein activity 8/1291 54/18639 0.148148148148148 2.13891040537051 0.0314202300957578 0.331133602690899 GO:0000400 four-way junction DNA binding 4/1291 18/18639 0.222222222222222 3.20836560805577 0.0320699965001418 0.331133602690899 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 4/1291 18/18639 0.222222222222222 3.20836560805577 0.0320699965001418 0.331133602690899 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 4/1291 18/18639 0.222222222222222 3.20836560805577 0.0320699965001418 0.331133602690899 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 4/1291 18/18639 0.222222222222222 3.20836560805577 0.0320699965001418 0.331133602690899 GO:1990381 ubiquitin-specific protease binding 4/1291 18/18639 0.222222222222222 3.20836560805577 0.0320699965001418 0.331133602690899 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 27/1291 268/18639 0.100746268656716 1.4545388857417 0.0322642997493696 0.331133602690899 GO:0004713 protein tyrosine kinase activity 16/1291 140/18639 0.114285714285714 1.65001659842868 0.032974811053253 0.335482860280922 GO:0004721 phosphoprotein phosphatase activity 19/1291 175/18639 0.108571428571429 1.56751576850725 0.0343528163376301 0.33639776549039 GO:0140313 molecular sequestering activity 8/1291 55/18639 0.145454545454545 2.10002112527287 0.0346207445146387 0.33639776549039 GO:0044390 ubiquitin-like protein conjugating enzyme binding 6/1291 36/18639 0.166666666666667 2.40627420604183 0.0355465532488598 0.33639776549039 GO:0004364 glutathione transferase activity 5/1291 27/18639 0.185185185185185 2.67363800671314 0.0356277544422946 0.33639776549039 GO:0023026 MHC class II protein complex binding 5/1291 27/18639 0.185185185185185 2.67363800671314 0.0356277544422946 0.33639776549039 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 3/1291 11/18639 0.272727272727273 3.93753960988663 0.0359399322105117 0.33639776549039 GO:0042608 T cell receptor binding 3/1291 11/18639 0.272727272727273 3.93753960988663 0.0359399322105117 0.33639776549039 GO:0043522 leucine zipper domain binding 3/1291 11/18639 0.272727272727273 3.93753960988663 0.0359399322105117 0.33639776549039 GO:0045294 alpha-catenin binding 3/1291 11/18639 0.272727272727273 3.93753960988663 0.0359399322105117 0.33639776549039 GO:0050786 RAGE receptor binding 3/1291 11/18639 0.272727272727273 3.93753960988663 0.0359399322105117 0.33639776549039 GO:0140996 histone H3 kinase activity 34/1291 357/18639 0.0952380952380952 1.3750138320239 0.0369391450218643 0.343006346631597 GO:0035091 phosphatidylinositol binding 28/1291 284/18639 0.0985915492957746 1.42342981202474 0.0376463716865276 0.346132291003396 GO:0004725 protein tyrosine phosphatase activity 12/1291 98/18639 0.122448979591837 1.76787492688787 0.0380408098002955 0.346132291003396 GO:0042577 lipid phosphatase activity 4/1291 19/18639 0.210526315789474 3.03950426026336 0.0384591434448218 0.346132291003396 GO:0043395 heparan sulfate proteoglycan binding 4/1291 19/18639 0.210526315789474 3.03950426026336 0.0384591434448218 0.346132291003396 GO:0023023 MHC protein complex binding 6/1291 37/18639 0.162162162162162 2.3412397680407 0.0400320657918033 0.357538297529847 GO:0035173 histone kinase activity 34/1291 360/18639 0.0944444444444444 1.3635553834237 0.040846599445838 0.360542324182145 GO:0097718 disordered domain specific binding 5/1291 28/18639 0.178571428571429 2.57815093504482 0.0409847257403635 0.360542324182145 GO:0106310 protein serine kinase activity 34/1291 361/18639 0.0941828254847645 1.35977822169677 0.0422158124070468 0.362922972111818 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 6/1291 38/18639 0.157894736842105 2.27962819519752 0.0448601722557045 0.362922972111818 GO:0003995 acyl-CoA dehydrogenase activity 3/1291 12/18639 0.25 3.60941130906274 0.0455105888737886 0.362922972111818 GO:0005025 transforming growth factor beta receptor activity, type I 3/1291 12/18639 0.25 3.60941130906274 0.0455105888737886 0.362922972111818 GO:0005026 transforming growth factor beta receptor activity, type II 3/1291 12/18639 0.25 3.60941130906274 0.0455105888737886 0.362922972111818 GO:0005095 GTPase inhibitor activity 3/1291 12/18639 0.25 3.60941130906274 0.0455105888737886 0.362922972111818 GO:0016361 activin receptor activity, type I 3/1291 12/18639 0.25 3.60941130906274 0.0455105888737886 0.362922972111818 GO:0016362 activin receptor activity, type II 3/1291 12/18639 0.25 3.60941130906274 0.0455105888737886 0.362922972111818 GO:0017002 activin receptor activity 3/1291 12/18639 0.25 3.60941130906274 0.0455105888737886 0.362922972111818 GO:0035259 nuclear glucocorticoid receptor binding 3/1291 12/18639 0.25 3.60941130906274 0.0455105888737886 0.362922972111818 GO:0045295 gamma-catenin binding 3/1291 12/18639 0.25 3.60941130906274 0.0455105888737886 0.362922972111818 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 3/1291 12/18639 0.25 3.60941130906274 0.0455105888737886 0.362922972111818 GO:0140939 histone H4 methyltransferase activity 4/1291 20/18639 0.2 2.88752904725019 0.0455218401279938 0.362922972111818 GO:0019210 kinase inhibitor activity 11/1291 90/18639 0.122222222222222 1.76460108443067 0.0462499603216947 0.362922972111818 GO:0099604 ligand-gated calcium channel activity 5/1291 29/18639 0.172413793103448 2.48924917866396 0.0468026711684554 0.362922972111818 GO:0002039 p53 binding 9/1291 69/18639 0.130434782608696 1.88317111777187 0.047827744750037 0.362922972111818 GO:0019838 growth factor binding 15/1291 136/18639 0.110294117647059 1.59238734223356 0.049542606637431 0.362922972111818 GO:0140789 histone phosphatase activity 15/1291 136/18639 0.110294117647059 1.59238734223356 0.049542606637431 0.362922972111818 GO:0036002 pre-mRNA binding 8/1291 59/18639 0.135593220338983 1.95764681169505 0.0496037166651015 0.362922972111818 GO:0141003 histone H2AX kinase activity 33/1291 354/18639 0.0932203389830508 1.34588218304034 0.0503883779254506 0.362922972111818 GO:0005004 GPI-linked ephrin receptor activity 7/1291 49/18639 0.142857142857143 2.06252074803585 0.0505610636360909 0.362922972111818 GO:0005008 hepatocyte growth factor receptor activity 7/1291 49/18639 0.142857142857143 2.06252074803585 0.0505610636360909 0.362922972111818 GO:0005009 insulin receptor activity 7/1291 49/18639 0.142857142857143 2.06252074803585 0.0505610636360909 0.362922972111818 GO:0005011 macrophage colony-stimulating factor receptor activity 7/1291 49/18639 0.142857142857143 2.06252074803585 0.0505610636360909 0.362922972111818 GO:0005018 platelet-derived growth factor alpha-receptor activity 7/1291 49/18639 0.142857142857143 2.06252074803585 0.0505610636360909 0.362922972111818 GO:0005020 stem cell factor receptor activity 7/1291 49/18639 0.142857142857143 2.06252074803585 0.0505610636360909 0.362922972111818 GO:0008288 boss receptor activity 7/1291 49/18639 0.142857142857143 2.06252074803585 0.0505610636360909 0.362922972111818 GO:0036332 placental growth factor receptor activity 7/1291 49/18639 0.142857142857143 2.06252074803585 0.0505610636360909 0.362922972111818 GO:0038062 protein tyrosine kinase collagen receptor activity 7/1291 49/18639 0.142857142857143 2.06252074803585 0.0505610636360909 0.362922972111818 GO:0060175 brain-derived neurotrophic factor receptor activity 7/1291 49/18639 0.142857142857143 2.06252074803585 0.0505610636360909 0.362922972111818 GO:0001965 G-protein alpha-subunit binding 5/1291 30/18639 0.166666666666667 2.40627420604183 0.0530851268617207 0.373610508961769 GO:0036122 BMP binding 4/1291 21/18639 0.19047619047619 2.7500276640478 0.0532565487534485 0.373610508961769 GO:1904047 S-adenosyl-L-methionine binding 4/1291 21/18639 0.19047619047619 2.7500276640478 0.0532565487534485 0.373610508961769 GO:0005178 integrin binding 17/1291 161/18639 0.105590062111801 1.52447185724389 0.0541575255540452 0.373610508961769 GO:0005006 epidermal growth factor receptor activity 7/1291 50/18639 0.14 2.02127033307514 0.0554315372364443 0.373610508961769 GO:0005007 fibroblast growth factor receptor activity 7/1291 50/18639 0.14 2.02127033307514 0.0554315372364443 0.373610508961769 GO:0005017 platelet-derived growth factor receptor activity 7/1291 50/18639 0.14 2.02127033307514 0.0554315372364443 0.373610508961769 GO:0005019 platelet-derived growth factor beta-receptor activity 7/1291 50/18639 0.14 2.02127033307514 0.0554315372364443 0.373610508961769 GO:0048020 CCR chemokine receptor binding 7/1291 50/18639 0.14 2.02127033307514 0.0554315372364443 0.373610508961769 GO:0004532 RNA exonuclease activity 6/1291 40/18639 0.15 2.16564678543765 0.0555622736208732 0.373610508961769 GO:0005338 nucleotide-sugar transmembrane transporter activity 3/1291 13/18639 0.230769230769231 3.33176428528868 0.0562012389549327 0.373610508961769 GO:0051011 microtubule minus-end binding 3/1291 13/18639 0.230769230769231 3.33176428528868 0.0562012389549327 0.373610508961769 GO:0070123 transforming growth factor beta receptor activity, type III 3/1291 13/18639 0.230769230769231 3.33176428528868 0.0562012389549327 0.373610508961769 GO:0030295 protein kinase activator activity 15/1291 139/18639 0.107913669064748 1.55801927009903 0.057912996760688 0.382814724350311 GO:0033218 amide binding 24/1291 247/18639 0.097165991902834 1.40284812012155 0.0586511943801286 0.385516277667138 GO:0005518 collagen binding 9/1291 72/18639 0.125 1.80470565453137 0.0599177986456354 0.38946775047534 GO:0005010 insulin-like growth factor receptor activity 7/1291 51/18639 0.137254901960784 1.98163758144621 0.060583872296164 0.38946775047534 GO:0005021 vascular endothelial growth factor receptor activity 7/1291 51/18639 0.137254901960784 1.98163758144621 0.060583872296164 0.38946775047534 GO:0005030 neurotrophin receptor activity 7/1291 51/18639 0.137254901960784 1.98163758144621 0.060583872296164 0.38946775047534 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 4/1291 22/18639 0.181818181818182 2.62502640659109 0.0616565885564552 0.394197861262583 GO:0140713 histone chaperone activity 17/1291 164/18639 0.103658536585366 1.49658517692845 0.0622941267384224 0.396109392847577 GO:0140597 protein carrier chaperone 19/1291 188/18639 0.101063829787234 1.45912372068494 0.0626488347436509 0.396211549459846 GO:0008276 protein methyltransferase activity 11/1291 95/18639 0.115789473684211 1.67172734314485 0.0638103314933149 0.401387569070852 GO:0004860 protein kinase inhibitor activity 10/1291 84/18639 0.119047619047619 1.71876729002988 0.0644257111912807 0.401593437272493 GO:0061775 cohesin loader activity 16/1291 153/18639 0.104575163398693 1.5098191096733 0.0647451843914646 0.401593437272493 GO:0016798 hydrolase activity, acting on glycosyl bonds 14/1291 130/18639 0.107692307692308 1.55482333313472 0.066199776505996 0.401593437272493 GO:0120015 sterol transfer activity 5/1291 32/18639 0.15625 2.25588206816421 0.0670454614109126 0.401593437272493 GO:0008307 structural constituent of muscle 6/1291 42/18639 0.142857142857143 2.06252074803585 0.067675560006901 0.401593437272493 GO:0035198 miRNA binding 6/1291 42/18639 0.142857142857143 2.06252074803585 0.067675560006901 0.401593437272493 GO:0005161 platelet-derived growth factor receptor binding 3/1291 14/18639 0.214285714285714 3.09378112205378 0.0679619663076527 0.401593437272493 GO:0008474 palmitoyl-(protein) hydrolase activity 3/1291 14/18639 0.214285714285714 3.09378112205378 0.0679619663076527 0.401593437272493 GO:0034236 protein kinase A catalytic subunit binding 3/1291 14/18639 0.214285714285714 3.09378112205378 0.0679619663076527 0.401593437272493 GO:0046030 inositol trisphosphate phosphatase activity 3/1291 14/18639 0.214285714285714 3.09378112205378 0.0679619663076527 0.401593437272493 GO:0098599 palmitoyl hydrolase activity 3/1291 14/18639 0.214285714285714 3.09378112205378 0.0679619663076527 0.401593437272493 GO:0098821 BMP receptor activity 3/1291 14/18639 0.214285714285714 3.09378112205378 0.0679619663076527 0.401593437272493 GO:0031072 heat shock protein binding 14/1291 131/18639 0.106870229007634 1.54295445272911 0.0696298163858989 0.403539266634206 GO:0031625 ubiquitin protein ligase binding 28/1291 302/18639 0.0927152317880795 1.33858962455307 0.0706981564124337 0.403539266634206 GO:0031681 G-protein beta-subunit binding 4/1291 23/18639 0.173913043478261 2.51089482369582 0.0707105634896498 0.403539266634206 GO:0044013 histone H2B acetyltransferase activity 4/1291 23/18639 0.173913043478261 2.51089482369582 0.0707105634896498 0.403539266634206 GO:0004386 helicase activity 16/1291 155/18639 0.103225806451613 1.49033757277429 0.0710165478311017 0.403539266634206 GO:0005003 ephrin receptor activity 7/1291 53/18639 0.132075471698113 1.90685880478786 0.0717403140683033 0.403539266634206 GO:0005005 transmembrane-ephrin receptor activity 7/1291 53/18639 0.132075471698113 1.90685880478786 0.0717403140683033 0.403539266634206 GO:0034212 protein N-acetyltransferase activity 7/1291 53/18639 0.132075471698113 1.90685880478786 0.0717403140683033 0.403539266634206 GO:0038064 collagen receptor activity 7/1291 53/18639 0.132075471698113 1.90685880478786 0.0717403140683033 0.403539266634206 GO:0051018 protein kinase A binding 7/1291 53/18639 0.132075471698113 1.90685880478786 0.0717403140683033 0.403539266634206 GO:0019955 cytokine binding 15/1291 144/18639 0.104166666666667 1.50392137877614 0.0739171992904439 0.413794847702485 GO:0140311 protein sequestering activity 5/1291 33/18639 0.151515151515152 2.18752200549257 0.0747184089393512 0.416288278376385 GO:0120013 lipid transfer activity 8/1291 65/18639 0.123076923076923 1.77694095215397 0.0789904753517223 0.438004057637512 GO:0047372 monoacylglycerol lipase activity 3/1291 15/18639 0.2 2.88752904725019 0.0807339583505945 0.443951318079435 GO:0140658 ATP-dependent chromatin remodeler activity 16/1291 158/18639 0.10126582278481 1.46204002392415 0.0811600258603221 0.443951318079435 GO:0001046 core promoter sequence-specific DNA binding 6/1291 44/18639 0.136363636363636 1.96876980494331 0.0812013521957258 0.443951318079435 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 5/1291 34/18639 0.147058823529412 2.12318312297808 0.0828462095549374 0.450837512461752 GO:0043130 ubiquitin binding 11/1291 100/18639 0.11 1.58814097598761 0.0852220976779744 0.461619695755695 GO:0015631 tubulin binding 34/1291 385/18639 0.0883116883116883 1.27501282605853 0.0862351171530507 0.464439272109092 GO:0030695 GTPase regulator activity 42/1291 489/18639 0.0858895705521472 1.24004314912585 0.0871993288208958 0.464439272109092 GO:0003727 single-stranded RNA binding 10/1291 89/18639 0.112359550561798 1.62220732991584 0.0876057178254211 0.464439272109092 GO:0004715 non-membrane spanning protein tyrosine kinase activity 6/1291 45/18639 0.133333333333333 1.92501936483346 0.0884886845914083 0.464439272109092 GO:0008009 chemokine activity 6/1291 45/18639 0.133333333333333 1.92501936483346 0.0884886845914083 0.464439272109092 GO:0140303 intramembrane lipid transporter activity 6/1291 45/18639 0.133333333333333 1.92501936483346 0.0884886845914083 0.464439272109092 GO:0002020 protease binding 14/1291 136/18639 0.102941176470588 1.48622818608466 0.0885213313507073 0.464439272109092 GO:0060589 nucleoside-triphosphatase regulator activity 42/1291 490/18639 0.0857142857142857 1.23751244882151 0.0892816257849253 0.465505155379331 GO:0003707 nuclear steroid receptor activity 4/1291 25/18639 0.16 2.31002323780016 0.090713825150844 0.465505155379331 GO:0019706 protein-cysteine S-palmitoyltransferase activity 4/1291 25/18639 0.16 2.31002323780016 0.090713825150844 0.465505155379331 GO:0019707 protein-cysteine S-acyltransferase activity 4/1291 25/18639 0.16 2.31002323780016 0.090713825150844 0.465505155379331 GO:0120020 cholesterol transfer activity 4/1291 25/18639 0.16 2.31002323780016 0.090713825150844 0.465505155379331 GO:0010485 histone H4 acetyltransferase activity 5/1291 35/18639 0.142857142857143 2.06252074803585 0.091421006439799 0.467085491417314 GO:0008094 ATP-dependent activity, acting on DNA 20/1291 210/18639 0.0952380952380952 1.3750138320239 0.0919480651460746 0.467735809656119 GO:0004708 MAP kinase kinase activity 3/1291 16/18639 0.1875 2.70705848179706 0.0944516956409667 0.468256287711572 GO:0005521 lamin binding 3/1291 16/18639 0.1875 2.70705848179706 0.0944516956409667 0.468256287711572 GO:0015923 mannosidase activity 3/1291 16/18639 0.1875 2.70705848179706 0.0944516956409667 0.468256287711572 GO:0030275 LRR domain binding 3/1291 16/18639 0.1875 2.70705848179706 0.0944516956409667 0.468256287711572 GO:0070411 I-SMAD binding 3/1291 16/18639 0.1875 2.70705848179706 0.0944516956409667 0.468256287711572 GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 3/1291 16/18639 0.1875 2.70705848179706 0.0944516956409667 0.468256287711572 GO:0005548 phospholipid transporter activity 8/1291 68/18639 0.117647058823529 1.69854649838247 0.096879294539619 0.474619194764033 GO:0032934 sterol binding 8/1291 68/18639 0.117647058823529 1.69854649838247 0.096879294539619 0.474619194764033 GO:0140104 molecular carrier activity 23/1291 249/18639 0.0923694779116466 1.33359775274607 0.0969521261099178 0.474619194764033 GO:1901681 sulfur compound binding 25/1291 275/18639 0.0909090909090909 1.31251320329554 0.0992718821719552 0.481361480460128 GO:0000510 H3-H4 histone complex chaperone activity 15/1291 151/18639 0.0993377483443709 1.434203169164 0.10080830470018 0.481361480460128 GO:0140584 chromatin extrusion motor activity 15/1291 151/18639 0.0993377483443709 1.434203169164 0.10080830470018 0.481361480460128 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 15/1291 151/18639 0.0993377483443709 1.434203169164 0.10080830470018 0.481361480460128 GO:0140849 ATP-dependent H2AZ histone chaperone activity 15/1291 151/18639 0.0993377483443709 1.434203169164 0.10080830470018 0.481361480460128 GO:0042826 histone deacetylase binding 13/1291 127/18639 0.102362204724409 1.47786919741152 0.101357719328644 0.481361480460128 GO:0034237 protein kinase A regulatory subunit binding 4/1291 26/18639 0.153846153846154 2.22117619019246 0.101620756986027 0.481361480460128 GO:0097602 cullin family protein binding 4/1291 26/18639 0.153846153846154 2.22117619019246 0.101620756986027 0.481361480460128 GO:0043178 alcohol binding 10/1291 92/18639 0.108695652173913 1.56930926480989 0.103646607991294 0.487891247696993 GO:0043495 protein-membrane adaptor activity 6/1291 47/18639 0.127659574468085 1.84310364718097 0.104090977940741 0.487891247696993 GO:0061980 regulatory RNA binding 7/1291 58/18639 0.120689655172414 1.74247442506477 0.10458555488866 0.487891247696993 GO:0015616 DNA translocase activity 15/1291 152/18639 0.0986842105263158 1.42476762199845 0.105084268734737 0.487891247696993 GO:0140674 ATP-dependent histone chaperone activity 15/1291 152/18639 0.0986842105263158 1.42476762199845 0.105084268734737 0.487891247696993 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 13/1291 128/18639 0.1015625 1.46632334430674 0.10606895866758 0.490516528225566 GO:0017110 nucleoside diphosphate phosphatase activity 3/1291 17/18639 0.176470588235294 2.5478197475737 0.109044831681875 0.496429778473904 GO:0031489 myosin V binding 3/1291 17/18639 0.176470588235294 2.5478197475737 0.109044831681875 0.496429778473904 GO:0046965 nuclear retinoid X receptor binding 3/1291 17/18639 0.176470588235294 2.5478197475737 0.109044831681875 0.496429778473904 GO:0070403 NAD+ binding 3/1291 17/18639 0.176470588235294 2.5478197475737 0.109044831681875 0.496429778473904 GO:0004879 nuclear receptor activity 7/1291 59/18639 0.11864406779661 1.71294096023317 0.111986956187985 0.503134703653275 GO:0032266 phosphatidylinositol-3-phosphate binding 6/1291 48/18639 0.125 1.80470565453137 0.112393994342268 0.503134703653275 GO:0140693 molecular condensate scaffold activity 6/1291 48/18639 0.125 1.80470565453137 0.112393994342268 0.503134703653275 GO:0004683 calcium/calmodulin-dependent protein kinase activity 4/1291 27/18639 0.148148148148148 2.13891040537051 0.113097800906676 0.503134703653275 GO:0005044 scavenger receptor activity 4/1291 27/18639 0.148148148148148 2.13891040537051 0.113097800906676 0.503134703653275 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 4/1291 27/18639 0.148148148148148 2.13891040537051 0.113097800906676 0.503134703653275 GO:0000287 magnesium ion binding 21/1291 230/18639 0.091304347826087 1.31821978244031 0.1185324004084 0.5253140472645 GO:0004714 transmembrane receptor protein tyrosine kinase activity 7/1291 60/18639 0.116666666666667 1.68439194422928 0.119656862534346 0.52631026001949 GO:0098531 ligand-modulated transcription factor activity 7/1291 60/18639 0.116666666666667 1.68439194422928 0.119656862534346 0.52631026001949 GO:0042379 chemokine receptor binding 8/1291 72/18639 0.111111111111111 1.60418280402789 0.123989556391949 0.532314460793608 GO:0017128 phospholipid scramblase activity 3/1291 18/18639 0.166666666666667 2.40627420604183 0.124439798718221 0.532314460793608 GO:0031690 adrenergic receptor binding 3/1291 18/18639 0.166666666666667 2.40627420604183 0.124439798718221 0.532314460793608 GO:0034185 apolipoprotein binding 3/1291 18/18639 0.166666666666667 2.40627420604183 0.124439798718221 0.532314460793608 GO:0036408 histone H3K14 acetyltransferase activity 4/1291 28/18639 0.142857142857143 2.06252074803585 0.125116646767728 0.532314460793608 GO:0046875 ephrin receptor binding 4/1291 28/18639 0.142857142857143 2.06252074803585 0.125116646767728 0.532314460793608 GO:0046966 nuclear thyroid hormone receptor binding 4/1291 28/18639 0.142857142857143 2.06252074803585 0.125116646767728 0.532314460793608 GO:0050698 proteoglycan sulfotransferase activity 4/1291 28/18639 0.142857142857143 2.06252074803585 0.125116646767728 0.532314460793608 GO:0051959 dynein light intermediate chain binding 4/1291 28/18639 0.142857142857143 2.06252074803585 0.125116646767728 0.532314460793608 GO:0032182 ubiquitin-like protein binding 12/1291 120/18639 0.1 1.4437645236251 0.127167601552335 0.539080050058811 GO:0000217 DNA secondary structure binding 5/1291 39/18639 0.128205128205128 1.85098015849371 0.129968531909973 0.548964557164868 GO:0003779 actin binding 37/1291 443/18639 0.0835214446952596 1.20585298812931 0.13621160419909 0.561362958696709 GO:0008237 metallopeptidase activity 17/1291 184/18639 0.0923913043478261 1.3339128750884 0.137614406552333 0.561362958696709 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 4/1291 29/18639 0.137931034482759 1.99139934293117 0.137646882863612 0.561362958696709 GO:0010484 histone H3 acetyltransferase activity 4/1291 29/18639 0.137931034482759 1.99139934293117 0.137646882863612 0.561362958696709 GO:0016417 S-acyltransferase activity 4/1291 29/18639 0.137931034482759 1.99139934293117 0.137646882863612 0.561362958696709 GO:0097472 cyclin-dependent protein kinase activity 4/1291 29/18639 0.137931034482759 1.99139934293117 0.137646882863612 0.561362958696709 GO:0003684 damaged DNA binding 8/1291 74/18639 0.108108108108108 1.56082651202713 0.138888720788742 0.561362958696709 GO:0004222 metalloendopeptidase activity 11/1291 110/18639 0.1 1.4437645236251 0.139810840272536 0.561362958696709 GO:0016918 retinal binding 3/1291 19/18639 0.157894736842105 2.27962819519752 0.140561171581984 0.561362958696709 GO:0046527 glucosyltransferase activity 3/1291 19/18639 0.157894736842105 2.27962819519752 0.140561171581984 0.561362958696709 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 5/1291 40/18639 0.125 1.80470565453137 0.140597997379844 0.561362958696709 GO:1901981 phosphatidylinositol phosphate binding 17/1291 185/18639 0.0918918918918919 1.32670253522306 0.142356962243625 0.561362958696709 GO:0003689 DNA clamp loader activity 15/1291 160/18639 0.09375 1.35352924089853 0.143172383122102 0.561362958696709 GO:0019003 GDP binding 8/1291 75/18639 0.106666666666667 1.54001549186677 0.146659802255836 0.561362958696709 GO:0008081 phosphoric diester hydrolase activity 9/1291 87/18639 0.103448275862069 1.49354950719838 0.147454823389859 0.561362958696709 GO:0008017 microtubule binding 24/1291 276/18639 0.0869565217391304 1.25544741184791 0.147850793767961 0.561362958696709 GO:0004090 carbonyl reductase (NADPH) activity 2/1291 10/18639 0.2 2.88752904725019 0.149103041802987 0.561362958696709 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 2/1291 10/18639 0.2 2.88752904725019 0.149103041802987 0.561362958696709 GO:0004445 inositol-polyphosphate 5-phosphatase activity 2/1291 10/18639 0.2 2.88752904725019 0.149103041802987 0.561362958696709 GO:0005381 iron ion transmembrane transporter activity 2/1291 10/18639 0.2 2.88752904725019 0.149103041802987 0.561362958696709 GO:0015924 mannosyl-oligosaccharide mannosidase activity 2/1291 10/18639 0.2 2.88752904725019 0.149103041802987 0.561362958696709 GO:0032356 oxidized DNA binding 2/1291 10/18639 0.2 2.88752904725019 0.149103041802987 0.561362958696709 GO:0032395 MHC class II receptor activity 2/1291 10/18639 0.2 2.88752904725019 0.149103041802987 0.561362958696709 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 2/1291 10/18639 0.2 2.88752904725019 0.149103041802987 0.561362958696709 GO:0043208 glycosphingolipid binding 2/1291 10/18639 0.2 2.88752904725019 0.149103041802987 0.561362958696709 GO:0043422 protein kinase B binding 2/1291 10/18639 0.2 2.88752904725019 0.149103041802987 0.561362958696709 GO:0045322 unmethylated CpG binding 2/1291 10/18639 0.2 2.88752904725019 0.149103041802987 0.561362958696709 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 2/1291 10/18639 0.2 2.88752904725019 0.149103041802987 0.561362958696709 GO:1905394 retromer complex binding 2/1291 10/18639 0.2 2.88752904725019 0.149103041802987 0.561362958696709 GO:0001968 fibronectin binding 4/1291 30/18639 0.133333333333333 1.92501936483346 0.15065638378698 0.561362958696709 GO:0008187 poly-pyrimidine tract binding 4/1291 30/18639 0.133333333333333 1.92501936483346 0.15065638378698 0.561362958696709 GO:0031210 phosphatidylcholine binding 4/1291 30/18639 0.133333333333333 1.92501936483346 0.15065638378698 0.561362958696709 GO:0043995 histone H4K5 acetyltransferase activity 4/1291 30/18639 0.133333333333333 1.92501936483346 0.15065638378698 0.561362958696709 GO:0043996 histone H4K8 acetyltransferase activity 4/1291 30/18639 0.133333333333333 1.92501936483346 0.15065638378698 0.561362958696709 GO:0043997 histone H4K12 acetyltransferase activity 4/1291 30/18639 0.133333333333333 1.92501936483346 0.15065638378698 0.561362958696709 GO:0048019 receptor antagonist activity 4/1291 30/18639 0.133333333333333 1.92501936483346 0.15065638378698 0.561362958696709 GO:0070566 adenylyltransferase activity 4/1291 30/18639 0.133333333333333 1.92501936483346 0.15065638378698 0.561362958696709 GO:0042169 SH2 domain binding 5/1291 41/18639 0.121951219512195 1.76068844344524 0.151591894045727 0.563055606455559 GO:0140034 methylation-dependent protein binding 8/1291 76/18639 0.105263157894737 1.51975213013168 0.154638483647765 0.57255387932875 GO:0010851 cyclase regulator activity 3/1291 20/18639 0.15 2.16564678543765 0.157332818309158 0.57705140257591 GO:0042288 MHC class I protein binding 3/1291 20/18639 0.15 2.16564678543765 0.157332818309158 0.57705140257591 GO:0052745 inositol phosphate phosphatase activity 3/1291 20/18639 0.15 2.16564678543765 0.157332818309158 0.57705140257591 GO:0038024 cargo receptor activity 7/1291 65/18639 0.107692307692308 1.55482333313472 0.161827625866625 0.586554981069993 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 9/1291 89/18639 0.101123595505618 1.45998659692426 0.162405766742555 0.586554981069993 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 9/1291 89/18639 0.101123595505618 1.45998659692426 0.162405766742555 0.586554981069993 GO:0004402 histone acetyltransferase activity 5/1291 42/18639 0.119047619047619 1.71876729002988 0.162931939186109 0.586554981069993 GO:0042056 chemoattractant activity 5/1291 42/18639 0.119047619047619 1.71876729002988 0.162931939186109 0.586554981069993 GO:0048487 beta-tubulin binding 5/1291 42/18639 0.119047619047619 1.71876729002988 0.162931939186109 0.586554981069993 GO:0017147 Wnt-protein binding 4/1291 31/18639 0.129032258064516 1.86292196596787 0.16411167573022 0.588974841455558 GO:0019902 phosphatase binding 17/1291 190/18639 0.0894736842105263 1.29178931061193 0.167411543925963 0.588974841455558 GO:0015485 cholesterol binding 6/1291 54/18639 0.111111111111111 1.60418280402789 0.168703707001559 0.588974841455558 GO:0140793 histone H2AXY142 phosphatase activity 9/1291 90/18639 0.1 1.4437645236251 0.170142497768018 0.588974841455558 GO:0005319 lipid transporter activity 16/1291 178/18639 0.0898876404494382 1.29776586393267 0.171717820306036 0.588974841455558 GO:0008172 S-methyltransferase activity 2/1291 11/18639 0.181818181818182 2.62502640659109 0.174250399490204 0.588974841455558 GO:0010854 adenylate cyclase regulator activity 2/1291 11/18639 0.181818181818182 2.62502640659109 0.174250399490204 0.588974841455558 GO:0016176 superoxide-generating NADPH oxidase activator activity 2/1291 11/18639 0.181818181818182 2.62502640659109 0.174250399490204 0.588974841455558 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 2/1291 11/18639 0.181818181818182 2.62502640659109 0.174250399490204 0.588974841455558 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 2/1291 11/18639 0.181818181818182 2.62502640659109 0.174250399490204 0.588974841455558 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 2/1291 11/18639 0.181818181818182 2.62502640659109 0.174250399490204 0.588974841455558 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 2/1291 11/18639 0.181818181818182 2.62502640659109 0.174250399490204 0.588974841455558 GO:0034056 estrogen response element binding 2/1291 11/18639 0.181818181818182 2.62502640659109 0.174250399490204 0.588974841455558 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 2/1291 11/18639 0.181818181818182 2.62502640659109 0.174250399490204 0.588974841455558 GO:0050998 nitric-oxide synthase binding 2/1291 11/18639 0.181818181818182 2.62502640659109 0.174250399490204 0.588974841455558 GO:0097493 structural molecule activity conferring elasticity 2/1291 11/18639 0.181818181818182 2.62502640659109 0.174250399490204 0.588974841455558 GO:0180030 inositol phosphate kinase activity 2/1291 11/18639 0.181818181818182 2.62502640659109 0.174250399490204 0.588974841455558 GO:0048156 tau protein binding 5/1291 43/18639 0.116279069767442 1.6787959577036 0.174598953814751 0.588974841455558 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 3/1291 21/18639 0.142857142857143 2.06252074803585 0.17467886323511 0.588974841455558 GO:0009975 cyclase activity 3/1291 21/18639 0.142857142857143 2.06252074803585 0.17467886323511 0.588974841455558 GO:0010314 phosphatidylinositol-5-phosphate binding 3/1291 21/18639 0.142857142857143 2.06252074803585 0.17467886323511 0.588974841455558 GO:0051010 microtubule plus-end binding 3/1291 21/18639 0.142857142857143 2.06252074803585 0.17467886323511 0.588974841455558 GO:0070717 poly-purine tract binding 4/1291 32/18639 0.125 1.80470565453137 0.177978277775835 0.597329072923596 GO:0140097 catalytic activity, acting on DNA 28/1291 336/18639 0.0833333333333333 1.20313710302091 0.178177646538748 0.597329072923596 GO:0004857 enzyme inhibitor activity 34/1291 416/18639 0.0817307692307692 1.17999985103974 0.178710555513717 0.597403857002998 GO:0050840 extracellular matrix binding 7/1291 67/18639 0.104477611940299 1.50841069632473 0.180344232338989 0.599683397384579 GO:0005543 phospholipid binding 40/1291 497/18639 0.0804828973843058 1.1619835200202 0.180417569127668 0.599683397384579 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 15/1291 167/18639 0.0898203592814371 1.29679448229799 0.18194029353014 0.603031567791116 GO:0035591 signaling adaptor activity 12/1291 129/18639 0.0930232558139535 1.34303676616288 0.182801744671446 0.604175257812406 GO:0043014 alpha-tubulin binding 5/1291 44/18639 0.113636363636364 1.64064150411943 0.18657300530437 0.604490266711254 GO:0019208 phosphatase regulator activity 11/1291 117/18639 0.094017094017094 1.35738544956206 0.186854761198906 0.604490266711254 GO:0140857 histone H3T45 kinase activity 21/1291 246/18639 0.0853658536585366 1.23248191041167 0.188286157773707 0.604490266711254 GO:0031683 G-protein beta/gamma-subunit complex binding 3/1291 22/18639 0.136363636363636 1.96876980494331 0.192524485552792 0.604490266711254 GO:0032931 histone H3K56 acetyltransferase activity 3/1291 22/18639 0.136363636363636 1.96876980494331 0.192524485552792 0.604490266711254 GO:0043992 histone H3K9 acetyltransferase activity 3/1291 22/18639 0.136363636363636 1.96876980494331 0.192524485552792 0.604490266711254 GO:0043993 histone H3K18 acetyltransferase activity 3/1291 22/18639 0.136363636363636 1.96876980494331 0.192524485552792 0.604490266711254 GO:0043994 histone H3K23 acetyltransferase activity 3/1291 22/18639 0.136363636363636 1.96876980494331 0.192524485552792 0.604490266711254 GO:0043999 histone H2AK5 acetyltransferase activity 3/1291 22/18639 0.136363636363636 1.96876980494331 0.192524485552792 0.604490266711254 GO:0044012 histone H2AK9 acetyltransferase activity 3/1291 22/18639 0.136363636363636 1.96876980494331 0.192524485552792 0.604490266711254 GO:0044014 histone H2BK5 acetyltransferase activity 3/1291 22/18639 0.136363636363636 1.96876980494331 0.192524485552792 0.604490266711254 GO:0044015 histone H2BK12 acetyltransferase activity 3/1291 22/18639 0.136363636363636 1.96876980494331 0.192524485552792 0.604490266711254 GO:0044016 histone H3K4 acetyltransferase activity 3/1291 22/18639 0.136363636363636 1.96876980494331 0.192524485552792 0.604490266711254 GO:0044017 histone H3K27 acetyltransferase activity 3/1291 22/18639 0.136363636363636 1.96876980494331 0.192524485552792 0.604490266711254 GO:0044018 histone H3K36 acetyltransferase activity 3/1291 22/18639 0.136363636363636 1.96876980494331 0.192524485552792 0.604490266711254 GO:0046972 histone H4K16 acetyltransferase activity 3/1291 22/18639 0.136363636363636 1.96876980494331 0.192524485552792 0.604490266711254 GO:0050321 tau-protein kinase activity 3/1291 22/18639 0.136363636363636 1.96876980494331 0.192524485552792 0.604490266711254 GO:0140908 histone H3K122 acetyltransferase activity 3/1291 22/18639 0.136363636363636 1.96876980494331 0.192524485552792 0.604490266711254 GO:0140375 immune receptor activity 14/1291 156/18639 0.0897435897435897 1.2956861109456 0.192979876725477 0.604490266711254 GO:0035403 histone H3T6 kinase activity 21/1291 247/18639 0.0850202429149798 1.22749210510636 0.193230222008555 0.604490266711254 GO:0051539 4 iron, 4 sulfur cluster binding 5/1291 45/18639 0.111111111111111 1.60418280402789 0.19883354539349 0.607787228799427 GO:0008080 N-acetyltransferase activity 7/1291 69/18639 0.101449275362319 1.4646886471559 0.199700712140473 0.607787228799427 GO:0005049 nuclear export signal receptor activity 2/1291 12/18639 0.166666666666667 2.40627420604183 0.199998361613487 0.607787228799427 GO:0005165 neurotrophin receptor binding 2/1291 12/18639 0.166666666666667 2.40627420604183 0.199998361613487 0.607787228799427 GO:0016273 arginine N-methyltransferase activity 2/1291 12/18639 0.166666666666667 2.40627420604183 0.199998361613487 0.607787228799427 GO:0016274 protein-arginine N-methyltransferase activity 2/1291 12/18639 0.166666666666667 2.40627420604183 0.199998361613487 0.607787228799427 GO:0035014 phosphatidylinositol 3-kinase regulator activity 2/1291 12/18639 0.166666666666667 2.40627420604183 0.199998361613487 0.607787228799427 GO:0035251 UDP-glucosyltransferase activity 2/1291 12/18639 0.166666666666667 2.40627420604183 0.199998361613487 0.607787228799427 GO:0042301 phosphate ion binding 2/1291 12/18639 0.166666666666667 2.40627420604183 0.199998361613487 0.607787228799427 GO:0097677 STAT family protein binding 2/1291 12/18639 0.166666666666667 2.40627420604183 0.199998361613487 0.607787228799427 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 2/1291 12/18639 0.166666666666667 2.40627420604183 0.199998361613487 0.607787228799427 GO:0016410 N-acyltransferase activity 9/1291 94/18639 0.0957446808510638 1.38232773538573 0.202716954822878 0.614452945965718 GO:0008376 acetylgalactosaminyltransferase activity 4/1291 34/18639 0.117647058823529 1.69854649838247 0.206804326138348 0.625222381348494 GO:0016782 transferase activity, transferring sulphur-containing groups 7/1291 70/18639 0.1 1.4437645236251 0.209670019608621 0.631588808112417 GO:0016849 phosphorus-oxygen lyase activity 3/1291 23/18639 0.130434782608696 1.88317111777187 0.210796573862264 0.631588808112417 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 5/1291 46/18639 0.108695652173913 1.56930926480989 0.211359542835377 0.631588808112417 GO:0030291 protein serine/threonine kinase inhibitor activity 5/1291 46/18639 0.108695652173913 1.56930926480989 0.211359542835377 0.631588808112417 GO:0008408 3'-5' exonuclease activity 6/1291 58/18639 0.103448275862069 1.49354950719838 0.211609241692365 0.631588808112417 GO:0008201 heparin binding 15/1291 172/18639 0.0872093023255814 1.2590969682777 0.212475772507299 0.632561460136233 GO:0005496 steroid binding 10/1291 108/18639 0.0925925925925926 1.33681900335657 0.214462730475706 0.636856331615676 GO:0001540 amyloid-beta binding 8/1291 83/18639 0.0963855421686747 1.39158026373503 0.215788690127312 0.639171563161912 GO:0003697 single-stranded DNA binding 11/1291 121/18639 0.0909090909090909 1.31251320329554 0.21660902080305 0.639981197827193 GO:0005154 epidermal growth factor receptor binding 4/1291 35/18639 0.114285714285714 1.65001659842868 0.221692496422032 0.645335738577958 GO:0004620 phospholipase activity 10/1291 109/18639 0.0917431192660551 1.32455460883036 0.222624555245492 0.645335738577958 GO:0070888 E-box binding 6/1291 59/18639 0.101694915254237 1.46823510877129 0.222887236277767 0.645335738577958 GO:0061733 protein-lysine-acetyltransferase activity 5/1291 47/18639 0.106382978723404 1.53591970598415 0.224129610084738 0.645335738577958 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 2/1291 13/18639 0.153846153846154 2.22117619019246 0.226143293005951 0.645335738577958 GO:0008253 5'-nucleotidase activity 2/1291 13/18639 0.153846153846154 2.22117619019246 0.226143293005951 0.645335738577958 GO:0019104 DNA N-glycosylase activity 2/1291 13/18639 0.153846153846154 2.22117619019246 0.226143293005951 0.645335738577958 GO:0031432 titin binding 2/1291 13/18639 0.153846153846154 2.22117619019246 0.226143293005951 0.645335738577958 GO:0035673 oligopeptide transmembrane transporter activity 2/1291 13/18639 0.153846153846154 2.22117619019246 0.226143293005951 0.645335738577958 GO:0039706 co-receptor binding 2/1291 13/18639 0.153846153846154 2.22117619019246 0.226143293005951 0.645335738577958 GO:0043560 insulin receptor substrate binding 2/1291 13/18639 0.153846153846154 2.22117619019246 0.226143293005951 0.645335738577958 GO:0046974 histone H3K9 methyltransferase activity 2/1291 13/18639 0.153846153846154 2.22117619019246 0.226143293005951 0.645335738577958 GO:0097157 pre-mRNA intronic binding 2/1291 13/18639 0.153846153846154 2.22117619019246 0.226143293005951 0.645335738577958 GO:0140852 histone ubiquitin ligase activity 2/1291 13/18639 0.153846153846154 2.22117619019246 0.226143293005951 0.645335738577958 GO:0015295 solute:proton symporter activity 3/1291 24/18639 0.125 1.80470565453137 0.229424255025446 0.649942804793637 GO:0043998 histone H2A acetyltransferase activity 3/1291 24/18639 0.125 1.80470565453137 0.229424255025446 0.649942804793637 GO:0050431 transforming growth factor beta binding 3/1291 24/18639 0.125 1.80470565453137 0.229424255025446 0.649942804793637 GO:0044325 transmembrane transporter binding 12/1291 136/18639 0.0882352941176471 1.27390987378685 0.232755179989886 0.651752304003645 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 6/1291 60/18639 0.1 1.4437645236251 0.234357277804814 0.651752304003645 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 6/1291 60/18639 0.1 1.4437645236251 0.234357277804814 0.651752304003645 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 6/1291 60/18639 0.1 1.4437645236251 0.234357277804814 0.651752304003645 GO:0016409 palmitoyltransferase activity 4/1291 36/18639 0.111111111111111 1.60418280402789 0.236849931597413 0.651752304003645 GO:0009378 four-way junction helicase activity 5/1291 48/18639 0.104166666666667 1.50392137877614 0.237122123543165 0.651752304003645 GO:0043138 3'-5' DNA helicase activity 5/1291 48/18639 0.104166666666667 1.50392137877614 0.237122123543165 0.651752304003645 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 19/1291 229/18639 0.0829694323144105 1.1978832292086 0.238720090076478 0.651752304003645 GO:1902936 phosphatidylinositol bisphosphate binding 10/1291 111/18639 0.0900900900900901 1.30068876002261 0.239301693033889 0.651752304003645 GO:0043539 protein serine/threonine kinase activator activity 7/1291 73/18639 0.0958904109589041 1.38443173498297 0.240619992766647 0.651752304003645 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 20/1291 243/18639 0.0823045267489712 1.18828355853917 0.242542590515593 0.651752304003645 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 6/1291 61/18639 0.0983606557377049 1.420096252746 0.246004615600786 0.651752304003645 GO:0000030 mannosyltransferase activity 3/1291 25/18639 0.12 1.73251742835012 0.24833931364471 0.651752304003645 GO:0004709 MAP kinase kinase kinase activity 3/1291 25/18639 0.12 1.73251742835012 0.24833931364471 0.651752304003645 GO:0008483 transaminase activity 3/1291 25/18639 0.12 1.73251742835012 0.24833931364471 0.651752304003645 GO:0017056 structural constituent of nuclear pore 3/1291 25/18639 0.12 1.73251742835012 0.24833931364471 0.651752304003645 GO:0042974 nuclear retinoic acid receptor binding 3/1291 25/18639 0.12 1.73251742835012 0.24833931364471 0.651752304003645 GO:0035064 methylated histone binding 7/1291 74/18639 0.0945945945945946 1.36572319802374 0.251248633122548 0.651752304003645 GO:0008195 phosphatidate phosphatase activity 2/1291 14/18639 0.142857142857143 2.06252074803585 0.252506847455667 0.651752304003645 GO:0015386 potassium:proton antiporter activity 2/1291 14/18639 0.142857142857143 2.06252074803585 0.252506847455667 0.651752304003645 GO:0019763 immunoglobulin receptor activity 2/1291 14/18639 0.142857142857143 2.06252074803585 0.252506847455667 0.651752304003645 GO:0019992 diacylglycerol binding 2/1291 14/18639 0.142857142857143 2.06252074803585 0.252506847455667 0.651752304003645 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 2/1291 14/18639 0.142857142857143 2.06252074803585 0.252506847455667 0.651752304003645 GO:0044548 S100 protein binding 2/1291 14/18639 0.142857142857143 2.06252074803585 0.252506847455667 0.651752304003645 GO:0070742 C2H2 zinc finger domain binding 2/1291 14/18639 0.142857142857143 2.06252074803585 0.252506847455667 0.651752304003645 GO:1901474 azole transmembrane transporter activity 2/1291 14/18639 0.142857142857143 2.06252074803585 0.252506847455667 0.651752304003645 GO:0004676 3-phosphoinositide-dependent protein kinase activity 20/1291 245/18639 0.0816326530612245 1.17858328459192 0.254016282586036 0.651752304003645 GO:0004711 ribosomal protein S6 kinase activity 20/1291 245/18639 0.0816326530612245 1.17858328459192 0.254016282586036 0.651752304003645 GO:0035175 histone H3S10 kinase activity 20/1291 245/18639 0.0816326530612245 1.17858328459192 0.254016282586036 0.651752304003645 GO:0035979 histone H2AXS139 kinase activity 20/1291 245/18639 0.0816326530612245 1.17858328459192 0.254016282586036 0.651752304003645 GO:0044022 histone H3S28 kinase activity 20/1291 245/18639 0.0816326530612245 1.17858328459192 0.254016282586036 0.651752304003645 GO:0044023 histone H4S1 kinase activity 20/1291 245/18639 0.0816326530612245 1.17858328459192 0.254016282586036 0.651752304003645 GO:0044024 histone H2AS1 kinase activity 20/1291 245/18639 0.0816326530612245 1.17858328459192 0.254016282586036 0.651752304003645 GO:0044025 histone H2BS14 kinase activity 20/1291 245/18639 0.0816326530612245 1.17858328459192 0.254016282586036 0.651752304003645 GO:0072354 histone H3T3 kinase activity 20/1291 245/18639 0.0816326530612245 1.17858328459192 0.254016282586036 0.651752304003645 GO:0072371 histone H2AS121 kinase activity 20/1291 245/18639 0.0816326530612245 1.17858328459192 0.254016282586036 0.651752304003645 GO:0072518 Rho-dependent protein serine/threonine kinase activity 20/1291 245/18639 0.0816326530612245 1.17858328459192 0.254016282586036 0.651752304003645 GO:0140823 histone H2BS36 kinase activity 20/1291 245/18639 0.0816326530612245 1.17858328459192 0.254016282586036 0.651752304003645 GO:0140855 histone H3S57 kinase activity 20/1291 245/18639 0.0816326530612245 1.17858328459192 0.254016282586036 0.651752304003645 GO:0140995 histone H2A kinase activity 20/1291 245/18639 0.0816326530612245 1.17858328459192 0.254016282586036 0.651752304003645 GO:0140997 histone H4 kinase activity 20/1291 245/18639 0.0816326530612245 1.17858328459192 0.254016282586036 0.651752304003645 GO:0140998 histone H2B kinase activity 20/1291 245/18639 0.0816326530612245 1.17858328459192 0.254016282586036 0.651752304003645 GO:1990244 histone H2AT120 kinase activity 20/1291 245/18639 0.0816326530612245 1.17858328459192 0.254016282586036 0.651752304003645 GO:0140767 enzyme-substrate adaptor activity 12/1291 139/18639 0.0863309352517986 1.24641541607922 0.255662107590645 0.654539750286772 GO:0004677 DNA-dependent protein kinase activity 20/1291 246/18639 0.0813008130081301 1.17379229563016 0.259833107790667 0.663765799377904 GO:0035402 histone H3T11 kinase activity 20/1291 247/18639 0.0809716599190283 1.16904010010129 0.265701203454289 0.666730771365547 GO:0005160 transforming growth factor beta receptor binding 3/1291 26/18639 0.115384615384615 1.66588214264434 0.267476516687147 0.666730771365547 GO:0008143 poly(A) binding 3/1291 26/18639 0.115384615384615 1.66588214264434 0.267476516687147 0.666730771365547 GO:0008198 ferrous iron binding 3/1291 26/18639 0.115384615384615 1.66588214264434 0.267476516687147 0.666730771365547 GO:0019865 immunoglobulin binding 3/1291 26/18639 0.115384615384615 1.66588214264434 0.267476516687147 0.666730771365547 GO:0030247 polysaccharide binding 3/1291 26/18639 0.115384615384615 1.66588214264434 0.267476516687147 0.666730771365547 GO:0030507 spectrin binding 3/1291 26/18639 0.115384615384615 1.66588214264434 0.267476516687147 0.666730771365547 GO:0043548 phosphatidylinositol 3-kinase binding 3/1291 26/18639 0.115384615384615 1.66588214264434 0.267476516687147 0.666730771365547 GO:0070006 metalloaminopeptidase activity 3/1291 26/18639 0.115384615384615 1.66588214264434 0.267476516687147 0.666730771365547 GO:0120014 phospholipid transfer activity 3/1291 26/18639 0.115384615384615 1.66588214264434 0.267476516687147 0.666730771365547 GO:0005501 retinoid binding 4/1291 38/18639 0.105263157894737 1.51975213013168 0.267832019266502 0.666730771365547 GO:0019840 isoprenoid binding 4/1291 38/18639 0.105263157894737 1.51975213013168 0.267832019266502 0.666730771365547 GO:0004679 AMP-activated protein kinase activity 20/1291 248/18639 0.0806451612903226 1.16432622872992 0.271618992239899 0.674281263557942 GO:0051536 iron-sulfur cluster binding 7/1291 76/18639 0.0921052631578947 1.32978311386522 0.272908413423291 0.674281263557942 GO:0005048 signal sequence binding 5/1291 51/18639 0.0980392156862745 1.41545541531872 0.277216896964713 0.674281263557942 GO:0004559 alpha-mannosidase activity 2/1291 15/18639 0.133333333333333 1.92501936483346 0.278933445779525 0.674281263557942 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 2/1291 15/18639 0.133333333333333 1.92501936483346 0.278933445779525 0.674281263557942 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 2/1291 15/18639 0.133333333333333 1.92501936483346 0.278933445779525 0.674281263557942 GO:0005523 tropomyosin binding 2/1291 15/18639 0.133333333333333 1.92501936483346 0.278933445779525 0.674281263557942 GO:0008252 nucleotidase activity 2/1291 15/18639 0.133333333333333 1.92501936483346 0.278933445779525 0.674281263557942 GO:0015929 hexosaminidase activity 2/1291 15/18639 0.133333333333333 1.92501936483346 0.278933445779525 0.674281263557942 GO:0034483 heparan sulfate sulfotransferase activity 2/1291 15/18639 0.133333333333333 1.92501936483346 0.278933445779525 0.674281263557942 GO:0051371 muscle alpha-actinin binding 2/1291 15/18639 0.133333333333333 1.92501936483346 0.278933445779525 0.674281263557942 GO:0061578 K63-linked deubiquitinase activity 2/1291 15/18639 0.133333333333333 1.92501936483346 0.278933445779525 0.674281263557942 GO:0120283 protein serine/threonine kinase binding 2/1291 15/18639 0.133333333333333 1.92501936483346 0.278933445779525 0.674281263557942 GO:0140776 protein-containing complex destabilizing activity 2/1291 15/18639 0.133333333333333 1.92501936483346 0.278933445779525 0.674281263557942 GO:0003724 RNA helicase activity 7/1291 77/18639 0.0909090909090909 1.31251320329554 0.283917335023202 0.683504695426226 GO:0051540 metal cluster binding 7/1291 77/18639 0.0909090909090909 1.31251320329554 0.283917335023202 0.683504695426226 GO:0005385 zinc ion transmembrane transporter activity 3/1291 27/18639 0.111111111111111 1.60418280402789 0.286773856159706 0.684745738177257 GO:0008266 poly(U) RNA binding 3/1291 27/18639 0.111111111111111 1.60418280402789 0.286773856159706 0.684745738177257 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 3/1291 27/18639 0.111111111111111 1.60418280402789 0.286773856159706 0.684745738177257 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 3/1291 27/18639 0.111111111111111 1.60418280402789 0.286773856159706 0.684745738177257 GO:0016298 lipase activity 11/1291 130/18639 0.0846153846153846 1.22164690460585 0.289691143296354 0.690302724351801 GO:0016758 hexosyltransferase activity 16/1291 197/18639 0.0812182741116751 1.17260062832495 0.29047117585631 0.690328618815824 GO:0030159 signaling receptor complex adaptor activity 5/1291 52/18639 0.0961538461538462 1.38823511887029 0.290882059039488 0.690328618815824 GO:0004177 aminopeptidase activity 4/1291 40/18639 0.1 1.4437645236251 0.29947560739442 0.697077200784941 GO:0015036 disulfide oxidoreductase activity 4/1291 40/18639 0.1 1.4437645236251 0.29947560739442 0.697077200784941 GO:0030331 nuclear estrogen receptor binding 4/1291 40/18639 0.1 1.4437645236251 0.29947560739442 0.697077200784941 GO:0032451 demethylase activity 4/1291 40/18639 0.1 1.4437645236251 0.29947560739442 0.697077200784941 GO:0050997 quaternary ammonium group binding 4/1291 40/18639 0.1 1.4437645236251 0.29947560739442 0.697077200784941 GO:0008194 UDP-glycosyltransferase activity 12/1291 145/18639 0.0827586206896552 1.1948396057587 0.303631252387013 0.697077200784941 GO:0008146 sulfotransferase activity 5/1291 53/18639 0.0943396226415094 1.3620420034199 0.304661728511538 0.697077200784941 GO:0140296 general transcription initiation factor binding 5/1291 53/18639 0.0943396226415094 1.3620420034199 0.304661728511538 0.697077200784941 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 2/1291 16/18639 0.125 1.80470565453137 0.305287981513605 0.697077200784941 GO:0005149 interleukin-1 receptor binding 2/1291 16/18639 0.125 1.80470565453137 0.305287981513605 0.697077200784941 GO:0005159 insulin-like growth factor receptor binding 2/1291 16/18639 0.125 1.80470565453137 0.305287981513605 0.697077200784941 GO:0008142 oxysterol binding 2/1291 16/18639 0.125 1.80470565453137 0.305287981513605 0.697077200784941 GO:0015385 sodium:proton antiporter activity 2/1291 16/18639 0.125 1.80470565453137 0.305287981513605 0.697077200784941 GO:0015562 efflux transmembrane transporter activity 2/1291 16/18639 0.125 1.80470565453137 0.305287981513605 0.697077200784941 GO:0019841 retinol binding 2/1291 16/18639 0.125 1.80470565453137 0.305287981513605 0.697077200784941 GO:0022858 alanine transmembrane transporter activity 2/1291 16/18639 0.125 1.80470565453137 0.305287981513605 0.697077200784941 GO:0043023 ribosomal large subunit binding 2/1291 16/18639 0.125 1.80470565453137 0.305287981513605 0.697077200784941 GO:0140328 floppase activity 2/1291 16/18639 0.125 1.80470565453137 0.305287981513605 0.697077200784941 GO:0045499 chemorepellent activity 3/1291 28/18639 0.107142857142857 1.54689056102689 0.306172721286743 0.697077200784941 GO:0141052 histone H3 demethylase activity 3/1291 28/18639 0.107142857142857 1.54689056102689 0.306172721286743 0.697077200784941 GO:0008186 ATP-dependent activity, acting on RNA 7/1291 79/18639 0.0886075949367089 1.27928502093363 0.306237334361931 0.697077200784941 GO:0051213 dioxygenase activity 8/1291 93/18639 0.0860215053763441 1.24194797731191 0.315433262408811 0.712532339694058 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 4/1291 41/18639 0.0975609756097561 1.40855075475619 0.315463035864549 0.712532339694058 GO:0042287 MHC protein binding 4/1291 41/18639 0.0975609756097561 1.40855075475619 0.315463035864549 0.712532339694058 GO:0140828 metal cation:monoatomic cation antiporter activity 4/1291 41/18639 0.0975609756097561 1.40855075475619 0.315463035864549 0.712532339694058 GO:0000049 tRNA binding 7/1291 80/18639 0.0875 1.26329395817196 0.317526046017611 0.713957749683315 GO:0031267 small GTPase binding 22/1291 283/18639 0.0777385159010601 1.12236111377216 0.317758081359779 0.713957749683315 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 5/1291 54/18639 0.0925925925925926 1.33681900335657 0.318534996012556 0.713957749683315 GO:0051287 NAD binding 5/1291 54/18639 0.0925925925925926 1.33681900335657 0.318534996012556 0.713957749683315 GO:0043236 laminin binding 3/1291 29/18639 0.103448275862069 1.49354950719838 0.325618010335566 0.721712781905288 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 3/1291 29/18639 0.103448275862069 1.49354950719838 0.325618010335566 0.721712781905288 GO:0033192 calmodulin-dependent protein phosphatase activity 7/1291 81/18639 0.0864197530864197 1.24769773646613 0.328885726909776 0.721712781905288 GO:0140791 histone H2AXS140 phosphatase activity 7/1291 81/18639 0.0864197530864197 1.24769773646613 0.328885726909776 0.721712781905288 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 7/1291 81/18639 0.0864197530864197 1.24769773646613 0.328885726909776 0.721712781905288 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 7/1291 81/18639 0.0864197530864197 1.24769773646613 0.328885726909776 0.721712781905288 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 7/1291 81/18639 0.0864197530864197 1.24769773646613 0.328885726909776 0.721712781905288 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 7/1291 81/18639 0.0864197530864197 1.24769773646613 0.328885726909776 0.721712781905288 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 7/1291 81/18639 0.0864197530864197 1.24769773646613 0.328885726909776 0.721712781905288 GO:1990439 MAP kinase serine/threonine phosphatase activity 7/1291 81/18639 0.0864197530864197 1.24769773646613 0.328885726909776 0.721712781905288 GO:0030145 manganese ion binding 6/1291 68/18639 0.0882352941176471 1.27390987378685 0.33124294977721 0.721712781905288 GO:0015278 intracellularly gated calcium channel activity 2/1291 17/18639 0.117647058823529 1.69854649838247 0.331453734824502 0.721712781905288 GO:0045125 bioactive lipid receptor activity 2/1291 17/18639 0.117647058823529 1.69854649838247 0.331453734824502 0.721712781905288 GO:0070402 NADPH binding 2/1291 17/18639 0.117647058823529 1.69854649838247 0.331453734824502 0.721712781905288 GO:1990226 histone methyltransferase binding 2/1291 17/18639 0.117647058823529 1.69854649838247 0.331453734824502 0.721712781905288 GO:0004843 cysteine-type deubiquitinase activity 9/1291 108/18639 0.0833333333333333 1.20313710302091 0.332439933914778 0.721712781905288 GO:0098632 cell-cell adhesion mediator activity 5/1291 55/18639 0.0909090909090909 1.31251320329554 0.332481358501667 0.721712781905288 GO:0008168 methyltransferase activity 16/1291 204/18639 0.0784313725490196 1.13236433225498 0.339778663068146 0.734607482017226 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 7/1291 82/18639 0.0853658536585366 1.23248191041167 0.340305346370373 0.734607482017226 GO:0033549 MAP kinase phosphatase activity 7/1291 82/18639 0.0853658536585366 1.23248191041167 0.340305346370373 0.734607482017226 GO:0051020 GTPase binding 24/1291 315/18639 0.0761904761904762 1.10001106561912 0.343494514949185 0.738058653645207 GO:0008106 alcohol dehydrogenase (NADP+) activity 3/1291 30/18639 0.1 1.4437645236251 0.345058191063186 0.738058653645207 GO:0016769 transferase activity, transferring nitrogenous groups 3/1291 30/18639 0.1 1.4437645236251 0.345058191063186 0.738058653645207 GO:0032452 histone demethylase activity 3/1291 30/18639 0.1 1.4437645236251 0.345058191063186 0.738058653645207 GO:0035925 mRNA 3'-UTR AU-rich region binding 3/1291 30/18639 0.1 1.4437645236251 0.345058191063186 0.738058653645207 GO:0004896 cytokine receptor activity 8/1291 96/18639 0.0833333333333333 1.20313710302091 0.347059920978705 0.739635897167732 GO:0016407 acetyltransferase activity 8/1291 96/18639 0.0833333333333333 1.20313710302091 0.347059920978705 0.739635897167732 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 7/1291 83/18639 0.0843373493975904 1.21763273076815 0.351773985761182 0.748319206073787 GO:0003746 translation elongation factor activity 2/1291 18/18639 0.111111111111111 1.60418280402789 0.357330476837787 0.753291275495874 GO:0004706 JUN kinase kinase kinase activity 2/1291 18/18639 0.111111111111111 1.60418280402789 0.357330476837787 0.753291275495874 GO:0004970 glutamate-gated receptor activity 2/1291 18/18639 0.111111111111111 1.60418280402789 0.357330476837787 0.753291275495874 GO:0035615 clathrin adaptor activity 2/1291 18/18639 0.111111111111111 1.60418280402789 0.357330476837787 0.753291275495874 GO:0098641 cadherin binding involved in cell-cell adhesion 2/1291 18/18639 0.111111111111111 1.60418280402789 0.357330476837787 0.753291275495874 GO:0004527 exonuclease activity 7/1291 84/18639 0.0833333333333333 1.20313710302091 0.363280864331153 0.75737304034818 GO:0017018 myosin phosphatase activity 7/1291 84/18639 0.0833333333333333 1.20313710302091 0.363280864331153 0.75737304034818 GO:0051117 ATPase binding 7/1291 84/18639 0.0833333333333333 1.20313710302091 0.363280864331153 0.75737304034818 GO:0016790 thiolester hydrolase activity 4/1291 44/18639 0.0909090909090909 1.31251320329554 0.363717327726429 0.75737304034818 GO:0030547 signaling receptor inhibitor activity 4/1291 44/18639 0.0909090909090909 1.31251320329554 0.363717327726429 0.75737304034818 GO:0008327 methyl-CpG binding 3/1291 31/18639 0.0967741935483871 1.3971914744759 0.364445317706005 0.75737304034818 GO:0070273 phosphatidylinositol-4-phosphate binding 3/1291 31/18639 0.0967741935483871 1.3971914744759 0.364445317706005 0.75737304034818 GO:0140457 protein demethylase activity 3/1291 31/18639 0.0967741935483871 1.3971914744759 0.364445317706005 0.75737304034818 GO:0070851 growth factor receptor binding 11/1291 139/18639 0.079136690647482 1.14254746473929 0.368520722367552 0.764484477251836 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 5/1291 58/18639 0.0862068965517241 1.24462458933198 0.3745613547494 0.774269938262894 GO:0017116 single-stranded DNA helicase activity 5/1291 58/18639 0.0862068965517241 1.24462458933198 0.3745613547494 0.774269938262894 GO:0008381 mechanosensitive monoatomic ion channel activity 2/1291 19/18639 0.105263157894737 1.51975213013168 0.382832748044352 0.782177636664642 GO:0022821 solute:potassium antiporter activity 2/1291 19/18639 0.105263157894737 1.51975213013168 0.382832748044352 0.782177636664642 GO:0030506 ankyrin binding 2/1291 19/18639 0.105263157894737 1.51975213013168 0.382832748044352 0.782177636664642 GO:0046624 sphingolipid transporter activity 2/1291 19/18639 0.105263157894737 1.51975213013168 0.382832748044352 0.782177636664642 GO:1990380 K48-linked deubiquitinase activity 2/1291 19/18639 0.105263157894737 1.51975213013168 0.382832748044352 0.782177636664642 GO:0022884 macromolecule transmembrane transporter activity 3/1291 32/18639 0.09375 1.35352924089853 0.383735011491884 0.782177636664642 GO:0043425 bHLH transcription factor binding 3/1291 32/18639 0.09375 1.35352924089853 0.383735011491884 0.782177636664642 GO:0140142 nucleocytoplasmic carrier activity 3/1291 32/18639 0.09375 1.35352924089853 0.383735011491884 0.782177636664642 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 7/1291 86/18639 0.0813953488372093 1.17515717039252 0.386367048974259 0.786172951825883 GO:0031593 polyubiquitin modification-dependent protein binding 5/1291 59/18639 0.0847457627118644 1.2235292573094 0.388605254607885 0.789354423422266 GO:0001653 peptide receptor activity 10/1291 128/18639 0.078125 1.12794103408211 0.394104890165849 0.799138165500941 GO:0101005 deubiquitinase activity 9/1291 115/18639 0.0782608695652174 1.12990267066312 0.402323169778237 0.80992628977383 GO:0001098 basal transcription machinery binding 5/1291 60/18639 0.0833333333333333 1.20313710302091 0.402627797953618 0.80992628977383 GO:0001099 basal RNA polymerase II transcription machinery binding 5/1291 60/18639 0.0833333333333333 1.20313710302091 0.402627797953618 0.80992628977383 GO:0019239 deaminase activity 3/1291 33/18639 0.0909090909090909 1.31251320329554 0.402886410810572 0.80992628977383 GO:0030296 protein tyrosine kinase activator activity 3/1291 33/18639 0.0909090909090909 1.31251320329554 0.402886410810572 0.80992628977383 GO:0003678 DNA helicase activity 6/1291 74/18639 0.0810810810810811 1.17061988402035 0.406797288596153 0.811614466118142 GO:0001614 purinergic nucleotide receptor activity 2/1291 20/18639 0.1 1.4437645236251 0.407888295792707 0.811614466118142 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 2/1291 20/18639 0.1 1.4437645236251 0.407888295792707 0.811614466118142 GO:0015095 magnesium ion transmembrane transporter activity 2/1291 20/18639 0.1 1.4437645236251 0.407888295792707 0.811614466118142 GO:0016502 nucleotide receptor activity 2/1291 20/18639 0.1 1.4437645236251 0.407888295792707 0.811614466118142 GO:0031418 L-ascorbic acid binding 2/1291 20/18639 0.1 1.4437645236251 0.407888295792707 0.811614466118142 GO:0008238 exopeptidase activity 8/1291 102/18639 0.0784313725490196 1.13236433225498 0.411237605436978 0.81284260994757 GO:0061749 forked DNA-dependent helicase activity 4/1291 47/18639 0.0851063829787234 1.22873576478732 0.411819439314785 0.81284260994757 GO:0140359 ABC-type transporter activity 4/1291 47/18639 0.0851063829787234 1.22873576478732 0.411819439314785 0.81284260994757 GO:1990518 single-stranded 3'-5' DNA helicase activity 4/1291 47/18639 0.0851063829787234 1.22873576478732 0.411819439314785 0.81284260994757 GO:0046982 protein heterodimerization activity 27/1291 369/18639 0.0731707317073171 1.05641306606714 0.411979203161461 0.81284260994757 GO:0015026 coreceptor activity 5/1291 61/18639 0.0819672131147541 1.183413543955 0.416612010663693 0.81922025626306 GO:0019905 syntaxin binding 5/1291 61/18639 0.0819672131147541 1.183413543955 0.416612010663693 0.81922025626306 GO:0016741 transferase activity, transferring one-carbon groups 16/1291 215/18639 0.0744186046511628 1.0744294129303 0.420249901067007 0.821447215571082 GO:0015020 glucuronosyltransferase activity 3/1291 34/18639 0.0882352941176471 1.27390987378685 0.421862096424013 0.821447215571082 GO:0015035 protein-disulfide reductase activity 3/1291 34/18639 0.0882352941176471 1.27390987378685 0.421862096424013 0.821447215571082 GO:0052866 phosphatidylinositol phosphate phosphatase activity 3/1291 34/18639 0.0882352941176471 1.27390987378685 0.421862096424013 0.821447215571082 GO:0090482 vitamin transmembrane transporter activity 3/1291 34/18639 0.0882352941176471 1.27390987378685 0.421862096424013 0.821447215571082 GO:0004722 protein serine/threonine phosphatase activity 8/1291 103/18639 0.0776699029126214 1.12137050378648 0.421957073981385 0.821447215571082 GO:0036121 double-stranded DNA helicase activity 4/1291 48/18639 0.0833333333333333 1.20313710302091 0.427701013475842 0.830789636821074 GO:0017022 myosin binding 6/1291 76/18639 0.0789473684210526 1.13981409759876 0.431942352457635 0.830789636821074 GO:0001846 opsonin binding 2/1291 21/18639 0.0952380952380952 1.3750138320239 0.432436657114559 0.830789636821074 GO:0008373 sialyltransferase activity 2/1291 21/18639 0.0952380952380952 1.3750138320239 0.432436657114559 0.830789636821074 GO:0009931 calcium-dependent protein serine/threonine kinase activity 2/1291 21/18639 0.0952380952380952 1.3750138320239 0.432436657114559 0.830789636821074 GO:0015174 basic amino acid transmembrane transporter activity 2/1291 21/18639 0.0952380952380952 1.3750138320239 0.432436657114559 0.830789636821074 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 2/1291 21/18639 0.0952380952380952 1.3750138320239 0.432436657114559 0.830789636821074 GO:0140312 cargo adaptor activity 2/1291 21/18639 0.0952380952380952 1.3750138320239 0.432436657114559 0.830789636821074 GO:0015085 calcium ion transmembrane transporter activity 11/1291 147/18639 0.0748299319727891 1.08036801087592 0.440516142966074 0.84237705198744 GO:0043015 gamma-tubulin binding 3/1291 35/18639 0.0857142857142857 1.23751244882151 0.440627996424199 0.84237705198744 GO:0061631 ubiquitin conjugating enzyme activity 3/1291 35/18639 0.0857142857142857 1.23751244882151 0.440627996424199 0.84237705198744 GO:0005126 cytokine receptor binding 20/1291 275/18639 0.0727272727272727 1.05001056263643 0.443816267679302 0.847088145489042 GO:0000149 SNARE binding 8/1291 106/18639 0.0754716981132075 1.08963360273592 0.453998981545692 0.854929977482362 GO:0004407 histone deacetylase activity 2/1291 22/18639 0.0909090909090909 1.31251320329554 0.456427874270735 0.854929977482362 GO:0033558 protein lysine deacetylase activity 2/1291 22/18639 0.0909090909090909 1.31251320329554 0.456427874270735 0.854929977482362 GO:0034062 5'-3' RNA polymerase activity 2/1291 22/18639 0.0909090909090909 1.31251320329554 0.456427874270735 0.854929977482362 GO:0097747 RNA polymerase activity 2/1291 22/18639 0.0909090909090909 1.31251320329554 0.456427874270735 0.854929977482362 GO:0140035 ubiquitin-like protein reader activity 2/1291 22/18639 0.0909090909090909 1.31251320329554 0.456427874270735 0.854929977482362 GO:0015605 organophosphate ester transmembrane transporter activity 4/1291 50/18639 0.08 1.15501161890008 0.459101771873043 0.854929977482362 GO:0000993 RNA polymerase II complex binding 3/1291 36/18639 0.0833333333333333 1.20313710302091 0.459153275044816 0.854929977482362 GO:0004033 aldo-keto reductase (NADPH) activity 3/1291 36/18639 0.0833333333333333 1.20313710302091 0.459153275044816 0.854929977482362 GO:0004869 cysteine-type endopeptidase inhibitor activity 3/1291 36/18639 0.0833333333333333 1.20313710302091 0.459153275044816 0.854929977482362 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 3/1291 36/18639 0.0833333333333333 1.20313710302091 0.459153275044816 0.854929977482362 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 3/1291 36/18639 0.0833333333333333 1.20313710302091 0.459153275044816 0.854929977482362 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 3/1291 36/18639 0.0833333333333333 1.20313710302091 0.459153275044816 0.854929977482362 GO:0015297 antiporter activity 10/1291 135/18639 0.0740740740740741 1.06945520268526 0.460436823121707 0.854929977482362 GO:0019888 protein phosphatase regulator activity 8/1291 107/18639 0.0747663551401869 1.07945011112157 0.464616394172022 0.854929977482362 GO:0008528 G protein-coupled peptide receptor activity 9/1291 122/18639 0.0737704918032787 1.0650721895595 0.472417124938887 0.854929977482362 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 9/1291 122/18639 0.0737704918032787 1.0650721895595 0.472417124938887 0.854929977482362 GO:0042805 actinin binding 3/1291 37/18639 0.0810810810810811 1.17061988402035 0.477410208897001 0.854929977482362 GO:0003887 DNA-directed DNA polymerase activity 2/1291 23/18639 0.0869565217391304 1.25544741184791 0.479821331452495 0.854929977482362 GO:0140103 catalytic activity, acting on a glycoprotein 2/1291 23/18639 0.0869565217391304 1.25544741184791 0.479821331452495 0.854929977482362 GO:0051015 actin filament binding 15/1291 209/18639 0.0717703349282297 1.03619463418069 0.481919879074343 0.854929977482362 GO:0008235 metalloexopeptidase activity 5/1291 66/18639 0.0757575757575758 1.09376100274629 0.485414881983056 0.854929977482362 GO:0004867 serine-type endopeptidase inhibitor activity 7/1291 95/18639 0.0736842105263158 1.06382649109218 0.489499407548884 0.854929977482362 GO:0001664 G protein-coupled receptor binding 21/1291 297/18639 0.0707070707070707 1.0208436025632 0.493686461705997 0.854929977482362 GO:0001618 virus receptor activity 6/1291 81/18639 0.0740740740740741 1.06945520268526 0.493808137765623 0.854929977482362 GO:0015101 organic cation transmembrane transporter activity 6/1291 81/18639 0.0740740740740741 1.06945520268526 0.493808137765623 0.854929977482362 GO:0005109 frizzled binding 3/1291 38/18639 0.0789473684210526 1.13981409759876 0.495374053722473 0.854929977482362 GO:0042887 amide transmembrane transporter activity 3/1291 38/18639 0.0789473684210526 1.13981409759876 0.495374053722473 0.854929977482362 GO:0043531 ADP binding 3/1291 38/18639 0.0789473684210526 1.13981409759876 0.495374053722473 0.854929977482362 GO:0140101 catalytic activity, acting on a tRNA 10/1291 139/18639 0.0719424460431655 1.03867951339935 0.497887186376662 0.854929977482362 GO:0001091 RNA polymerase II general transcription initiation factor binding 2/1291 24/18639 0.0833333333333333 1.20313710302091 0.502584702036772 0.854929977482362 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 2/1291 24/18639 0.0833333333333333 1.20313710302091 0.502584702036772 0.854929977482362 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 2/1291 24/18639 0.0833333333333333 1.20313710302091 0.502584702036772 0.854929977482362 GO:0004806 triacylglycerol lipase activity 2/1291 24/18639 0.0833333333333333 1.20313710302091 0.502584702036772 0.854929977482362 GO:0015149 hexose transmembrane transporter activity 2/1291 24/18639 0.0833333333333333 1.20313710302091 0.502584702036772 0.854929977482362 GO:0030552 cAMP binding 2/1291 24/18639 0.0833333333333333 1.20313710302091 0.502584702036772 0.854929977482362 GO:0050699 WW domain binding 2/1291 24/18639 0.0833333333333333 1.20313710302091 0.502584702036772 0.854929977482362 GO:0055056 D-glucose transmembrane transporter activity 2/1291 24/18639 0.0833333333333333 1.20313710302091 0.502584702036772 0.854929977482362 GO:0070840 dynein complex binding 2/1291 24/18639 0.0833333333333333 1.20313710302091 0.502584702036772 0.854929977482362 GO:1901505 carbohydrate derivative transmembrane transporter activity 4/1291 53/18639 0.0754716981132075 1.08963360273592 0.505010252034402 0.854929977482362 GO:0140272 exogenous protein binding 6/1291 82/18639 0.0731707317073171 1.05641306606714 0.505926779191563 0.854929977482362 GO:0030414 peptidase inhibitor activity 12/1291 169/18639 0.0710059171597633 1.02515824162729 0.507656295046295 0.854929977482362 GO:0003680 minor groove of adenine-thymine-rich DNA binding 1/1291 10/18639 0.1 1.4437645236251 0.512258178512413 0.854929977482362 GO:0003796 lysozyme activity 1/1291 10/18639 0.1 1.4437645236251 0.512258178512413 0.854929977482362 GO:0004862 cAMP-dependent protein kinase inhibitor activity 1/1291 10/18639 0.1 1.4437645236251 0.512258178512413 0.854929977482362 GO:0005528 FK506 binding 1/1291 10/18639 0.1 1.4437645236251 0.512258178512413 0.854929977482362 GO:0008190 eukaryotic initiation factor 4E binding 1/1291 10/18639 0.1 1.4437645236251 0.512258178512413 0.854929977482362 GO:0008401 retinoic acid 4-hydroxylase activity 1/1291 10/18639 0.1 1.4437645236251 0.512258178512413 0.854929977482362 GO:0008519 ammonium channel activity 1/1291 10/18639 0.1 1.4437645236251 0.512258178512413 0.854929977482362 GO:0015187 glycine transmembrane transporter activity 1/1291 10/18639 0.1 1.4437645236251 0.512258178512413 0.854929977482362 GO:0015658 branched-chain amino acid transmembrane transporter activity 1/1291 10/18639 0.1 1.4437645236251 0.512258178512413 0.854929977482362 GO:0016427 tRNA (cytidine) methyltransferase activity 1/1291 10/18639 0.1 1.4437645236251 0.512258178512413 0.854929977482362 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 1/1291 10/18639 0.1 1.4437645236251 0.512258178512413 0.854929977482362 GO:0016783 sulfurtransferase activity 1/1291 10/18639 0.1 1.4437645236251 0.512258178512413 0.854929977482362 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 1/1291 10/18639 0.1 1.4437645236251 0.512258178512413 0.854929977482362 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 1/1291 10/18639 0.1 1.4437645236251 0.512258178512413 0.854929977482362 GO:0031434 mitogen-activated protein kinase kinase binding 1/1291 10/18639 0.1 1.4437645236251 0.512258178512413 0.854929977482362 GO:0033204 ribonuclease P RNA binding 1/1291 10/18639 0.1 1.4437645236251 0.512258178512413 0.854929977482362 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 1/1291 10/18639 0.1 1.4437645236251 0.512258178512413 0.854929977482362 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 1/1291 10/18639 0.1 1.4437645236251 0.512258178512413 0.854929977482362 GO:0043121 neurotrophin binding 1/1291 10/18639 0.1 1.4437645236251 0.512258178512413 0.854929977482362 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 1/1291 10/18639 0.1 1.4437645236251 0.512258178512413 0.854929977482362 GO:0043295 glutathione binding 1/1291 10/18639 0.1 1.4437645236251 0.512258178512413 0.854929977482362 GO:0047429 nucleoside triphosphate diphosphatase activity 1/1291 10/18639 0.1 1.4437645236251 0.512258178512413 0.854929977482362 GO:0050815 phosphoserine residue binding 1/1291 10/18639 0.1 1.4437645236251 0.512258178512413 0.854929977482362 GO:0051378 serotonin binding 1/1291 10/18639 0.1 1.4437645236251 0.512258178512413 0.854929977482362 GO:0051864 histone H3K36 demethylase activity 1/1291 10/18639 0.1 1.4437645236251 0.512258178512413 0.854929977482362 GO:0070097 delta-catenin binding 1/1291 10/18639 0.1 1.4437645236251 0.512258178512413 0.854929977482362 GO:0099122 RNA polymerase II C-terminal domain binding 1/1291 10/18639 0.1 1.4437645236251 0.512258178512413 0.854929977482362 GO:0140135 mechanosensitive monoatomic cation channel activity 1/1291 10/18639 0.1 1.4437645236251 0.512258178512413 0.854929977482362 GO:0140940 histone H2A methyltransferase activity 1/1291 10/18639 0.1 1.4437645236251 0.512258178512413 0.854929977482362 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 1/1291 10/18639 0.1 1.4437645236251 0.512258178512413 0.854929977482362 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 1/1291 10/18639 0.1 1.4437645236251 0.512258178512413 0.854929977482362 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 1/1291 10/18639 0.1 1.4437645236251 0.512258178512413 0.854929977482362 GO:1990259 histone H2AQ104 methyltransferase activity 1/1291 10/18639 0.1 1.4437645236251 0.512258178512413 0.854929977482362 GO:1990757 ubiquitin ligase activator activity 1/1291 10/18639 0.1 1.4437645236251 0.512258178512413 0.854929977482362 GO:0005539 glycosaminoglycan binding 17/1291 242/18639 0.0702479338842975 1.0142147480011 0.512300153464626 0.854929977482362 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 3/1291 39/18639 0.0769230769230769 1.11058809509623 0.513022904333266 0.854929977482362 GO:0140098 catalytic activity, acting on RNA 27/1291 387/18639 0.0697674418604651 1.00727757462216 0.513465021272273 0.854929977482362 GO:0005200 structural constituent of cytoskeleton 8/1291 112/18639 0.0714285714285714 1.03126037401793 0.516923694817863 0.854929977482362 GO:0016887 ATP hydrolysis activity 29/1291 417/18639 0.0695443645083933 1.00405686295271 0.519094181284982 0.854929977482362 GO:0017069 snRNA binding 4/1291 54/18639 0.0740740740740741 1.06945520268526 0.519928272516149 0.854929977482362 GO:0050661 NADP binding 4/1291 54/18639 0.0740740740740741 1.06945520268526 0.519928272516149 0.854929977482362 GO:0140463 chromatin-protein adaptor activity 4/1291 54/18639 0.0740740740740741 1.06945520268526 0.519928272516149 0.854929977482362 GO:0019783 ubiquitin-like protein peptidase activity 9/1291 127/18639 0.0708661417322835 1.02314021359259 0.521442855262971 0.854929977482362 GO:0001848 complement binding 2/1291 25/18639 0.08 1.15501161890008 0.52469299667956 0.854929977482362 GO:0008139 nuclear localization sequence binding 2/1291 25/18639 0.08 1.15501161890008 0.52469299667956 0.854929977482362 GO:0015296 monoatomic anion:monoatomic cation symporter activity 2/1291 25/18639 0.08 1.15501161890008 0.52469299667956 0.854929977482362 GO:0015645 fatty acid ligase activity 2/1291 25/18639 0.08 1.15501161890008 0.52469299667956 0.854929977482362 GO:0017025 TBP-class protein binding 2/1291 25/18639 0.08 1.15501161890008 0.52469299667956 0.854929977482362 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 2/1291 25/18639 0.08 1.15501161890008 0.52469299667956 0.854929977482362 GO:0120515 fatty acid-CoA ligase activity 2/1291 25/18639 0.08 1.15501161890008 0.52469299667956 0.854929977482362 GO:0015144 carbohydrate transmembrane transporter activity 3/1291 40/18639 0.075 1.08282339271882 0.53033755003101 0.854929977482362 GO:0061791 GTPase motor activity 3/1291 40/18639 0.075 1.08282339271882 0.53033755003101 0.854929977482362 GO:1990606 membrane scission GTPase motor activity 3/1291 40/18639 0.075 1.08282339271882 0.53033755003101 0.854929977482362 GO:0031490 chromatin DNA binding 9/1291 128/18639 0.0703125 1.0151469306739 0.531073457665274 0.854929977482362 GO:0008374 O-acyltransferase activity 4/1291 55/18639 0.0727272727272727 1.05001056263643 0.534629991262383 0.854929977482362 GO:0019903 protein phosphatase binding 10/1291 144/18639 0.0694444444444444 1.00261425251743 0.543665448808157 0.854929977482362 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 1/1291 11/18639 0.0909090909090909 1.31251320329554 0.546058956414634 0.854929977482362 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 1/1291 11/18639 0.0909090909090909 1.31251320329554 0.546058956414634 0.854929977482362 GO:0001851 complement component C3b binding 1/1291 11/18639 0.0909090909090909 1.31251320329554 0.546058956414634 0.854929977482362 GO:0004016 adenylate cyclase activity 1/1291 11/18639 0.0909090909090909 1.31251320329554 0.546058956414634 0.854929977482362 GO:0004143 ATP-dependent diacylglycerol kinase activity 1/1291 11/18639 0.0909090909090909 1.31251320329554 0.546058956414634 0.854929977482362 GO:0004523 RNA-DNA hybrid ribonuclease activity 1/1291 11/18639 0.0909090909090909 1.31251320329554 0.546058956414634 0.854929977482362 GO:0005225 volume-sensitive anion channel activity 1/1291 11/18639 0.0909090909090909 1.31251320329554 0.546058956414634 0.854929977482362 GO:0008046 axon guidance receptor activity 1/1291 11/18639 0.0909090909090909 1.31251320329554 0.546058956414634 0.854929977482362 GO:0008199 ferric iron binding 1/1291 11/18639 0.0909090909090909 1.31251320329554 0.546058956414634 0.854929977482362 GO:0008432 JUN kinase binding 1/1291 11/18639 0.0909090909090909 1.31251320329554 0.546058956414634 0.854929977482362 GO:0008503 benzodiazepine receptor activity 1/1291 11/18639 0.0909090909090909 1.31251320329554 0.546058956414634 0.854929977482362 GO:0008526 phosphatidylinositol transfer activity 1/1291 11/18639 0.0909090909090909 1.31251320329554 0.546058956414634 0.854929977482362 GO:0015173 aromatic amino acid transmembrane transporter activity 1/1291 11/18639 0.0909090909090909 1.31251320329554 0.546058956414634 0.854929977482362 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 1/1291 11/18639 0.0909090909090909 1.31251320329554 0.546058956414634 0.854929977482362 GO:0019215 intermediate filament binding 1/1291 11/18639 0.0909090909090909 1.31251320329554 0.546058956414634 0.854929977482362 GO:0019864 IgG binding 1/1291 11/18639 0.0909090909090909 1.31251320329554 0.546058956414634 0.854929977482362 GO:0032050 clathrin heavy chain binding 1/1291 11/18639 0.0909090909090909 1.31251320329554 0.546058956414634 0.854929977482362 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 1/1291 11/18639 0.0909090909090909 1.31251320329554 0.546058956414634 0.854929977482362 GO:0032404 mismatch repair complex binding 1/1291 11/18639 0.0909090909090909 1.31251320329554 0.546058956414634 0.854929977482362 GO:0032794 GTPase activating protein binding 1/1291 11/18639 0.0909090909090909 1.31251320329554 0.546058956414634 0.854929977482362 GO:0034713 type I transforming growth factor beta receptor binding 1/1291 11/18639 0.0909090909090909 1.31251320329554 0.546058956414634 0.854929977482362 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 1/1291 11/18639 0.0909090909090909 1.31251320329554 0.546058956414634 0.854929977482362 GO:0047676 arachidonate-CoA ligase activity 1/1291 11/18639 0.0909090909090909 1.31251320329554 0.546058956414634 0.854929977482362 GO:0070697 activin receptor binding 1/1291 11/18639 0.0909090909090909 1.31251320329554 0.546058956414634 0.854929977482362 GO:0070990 snRNP binding 1/1291 11/18639 0.0909090909090909 1.31251320329554 0.546058956414634 0.854929977482362 GO:0140031 phosphorylation-dependent protein binding 1/1291 11/18639 0.0909090909090909 1.31251320329554 0.546058956414634 0.854929977482362 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 1/1291 11/18639 0.0909090909090909 1.31251320329554 0.546058956414634 0.854929977482362 GO:1900750 oligopeptide binding 1/1291 11/18639 0.0909090909090909 1.31251320329554 0.546058956414634 0.854929977482362 GO:0004112 cyclic-nucleotide phosphodiesterase activity 2/1291 26/18639 0.0769230769230769 1.11058809509623 0.546127703345594 0.854929977482362 GO:0005112 Notch binding 2/1291 26/18639 0.0769230769230769 1.11058809509623 0.546127703345594 0.854929977482362 GO:0008066 glutamate receptor activity 2/1291 26/18639 0.0769230769230769 1.11058809509623 0.546127703345594 0.854929977482362 GO:0015145 monosaccharide transmembrane transporter activity 2/1291 26/18639 0.0769230769230769 1.11058809509623 0.546127703345594 0.854929977482362 GO:0051139 metal cation:proton antiporter activity 2/1291 26/18639 0.0769230769230769 1.11058809509623 0.546127703345594 0.854929977482362 GO:0052742 phosphatidylinositol kinase activity 2/1291 26/18639 0.0769230769230769 1.11058809509623 0.546127703345594 0.854929977482362 GO:0001727 lipid kinase activity 3/1291 41/18639 0.0731707317073171 1.05641306606714 0.547301327465204 0.854929977482362 GO:0017080 sodium channel regulator activity 3/1291 41/18639 0.0731707317073171 1.05641306606714 0.547301327465204 0.854929977482362 GO:0061650 ubiquitin-like protein conjugating enzyme activity 3/1291 41/18639 0.0731707317073171 1.05641306606714 0.547301327465204 0.854929977482362 GO:0140318 protein transporter activity 3/1291 41/18639 0.0731707317073171 1.05641306606714 0.547301327465204 0.854929977482362 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 9/1291 130/18639 0.0692307692307692 0.999529285586605 0.550122011885778 0.857483809987735 GO:0050660 flavin adenine dinucleotide binding 6/1291 86/18639 0.0697674418604651 1.00727757462216 0.553252272502194 0.857483809987735 GO:0005262 calcium channel activity 9/1291 131/18639 0.0687022900763359 0.991899291040143 0.559531269767222 0.857483809987735 GO:0015932 nucleobase-containing compound transmembrane transporter activity 4/1291 57/18639 0.0701754385964912 1.01316808675445 0.563336158176336 0.857483809987735 GO:0016859 cis-trans isomerase activity 3/1291 42/18639 0.0714285714285714 1.03126037401793 0.563899972594984 0.857483809987735 GO:0043175 RNA polymerase core enzyme binding 3/1291 42/18639 0.0714285714285714 1.03126037401793 0.563899972594984 0.857483809987735 GO:0008320 protein transmembrane transporter activity 2/1291 27/18639 0.0740740740740741 1.06945520268526 0.566876011120465 0.857483809987735 GO:0016405 CoA-ligase activity 2/1291 27/18639 0.0740740740740741 1.06945520268526 0.566876011120465 0.857483809987735 GO:0035255 ionotropic glutamate receptor binding 2/1291 27/18639 0.0740740740740741 1.06945520268526 0.566876011120465 0.857483809987735 GO:1990782 protein tyrosine kinase binding 8/1291 117/18639 0.0683760683760684 0.987189417863314 0.567382495858087 0.857483809987735 GO:0043021 ribonucleoprotein complex binding 12/1291 177/18639 0.0677966101694915 0.978823405847523 0.573488144120365 0.857483809987735 GO:0016651 oxidoreductase activity, acting on NAD(P)H 6/1291 88/18639 0.0681818181818182 0.984384902471657 0.576119651574966 0.857483809987735 GO:0000340 RNA 7-methylguanosine cap binding 1/1291 12/18639 0.0833333333333333 1.20313710302091 0.577519010487466 0.857483809987735 GO:0004000 adenosine deaminase activity 1/1291 12/18639 0.0833333333333333 1.20313710302091 0.577519010487466 0.857483809987735 GO:0004032 aldose reductase (NADPH) activity 1/1291 12/18639 0.0833333333333333 1.20313710302091 0.577519010487466 0.857483809987735 GO:0004126 cytidine deaminase activity 1/1291 12/18639 0.0833333333333333 1.20313710302091 0.577519010487466 0.857483809987735 GO:0004300 enoyl-CoA hydratase activity 1/1291 12/18639 0.0833333333333333 1.20313710302091 0.577519010487466 0.857483809987735 GO:0004526 ribonuclease P activity 1/1291 12/18639 0.0833333333333333 1.20313710302091 0.577519010487466 0.857483809987735 GO:0004859 phospholipase inhibitor activity 1/1291 12/18639 0.0833333333333333 1.20313710302091 0.577519010487466 0.857483809987735 GO:0005078 MAP-kinase scaffold activity 1/1291 12/18639 0.0833333333333333 1.20313710302091 0.577519010487466 0.857483809987735 GO:0005527 macrolide binding 1/1291 12/18639 0.0833333333333333 1.20313710302091 0.577519010487466 0.857483809987735 GO:0008179 adenylate cyclase binding 1/1291 12/18639 0.0833333333333333 1.20313710302091 0.577519010487466 0.857483809987735 GO:0008603 cAMP-dependent protein kinase regulator activity 1/1291 12/18639 0.0833333333333333 1.20313710302091 0.577519010487466 0.857483809987735 GO:0010853 cyclase activator activity 1/1291 12/18639 0.0833333333333333 1.20313710302091 0.577519010487466 0.857483809987735 GO:0015368 calcium:monoatomic cation antiporter activity 1/1291 12/18639 0.0833333333333333 1.20313710302091 0.577519010487466 0.857483809987735 GO:0016208 AMP binding 1/1291 12/18639 0.0833333333333333 1.20313710302091 0.577519010487466 0.857483809987735 GO:0017166 vinculin binding 1/1291 12/18639 0.0833333333333333 1.20313710302091 0.577519010487466 0.857483809987735 GO:0031543 peptidyl-proline dioxygenase activity 1/1291 12/18639 0.0833333333333333 1.20313710302091 0.577519010487466 0.857483809987735 GO:0034452 dynactin binding 1/1291 12/18639 0.0833333333333333 1.20313710302091 0.577519010487466 0.857483809987735 GO:0035197 siRNA binding 1/1291 12/18639 0.0833333333333333 1.20313710302091 0.577519010487466 0.857483809987735 GO:0036009 protein-glutamine N-methyltransferase activity 1/1291 12/18639 0.0833333333333333 1.20313710302091 0.577519010487466 0.857483809987735 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 1/1291 12/18639 0.0833333333333333 1.20313710302091 0.577519010487466 0.857483809987735 GO:0070008 serine-type exopeptidase activity 1/1291 12/18639 0.0833333333333333 1.20313710302091 0.577519010487466 0.857483809987735 GO:0070679 inositol 1,4,5 trisphosphate binding 1/1291 12/18639 0.0833333333333333 1.20313710302091 0.577519010487466 0.857483809987735 GO:0097371 MDM2/MDM4 family protein binding 1/1291 12/18639 0.0833333333333333 1.20313710302091 0.577519010487466 0.857483809987735 GO:0140829 bicarbonate:monoatomic anion antiporter activity 1/1291 12/18639 0.0833333333333333 1.20313710302091 0.577519010487466 0.857483809987735 GO:0140900 chloride:bicarbonate antiporter activity 1/1291 12/18639 0.0833333333333333 1.20313710302091 0.577519010487466 0.857483809987735 GO:0141221 histone deacetylase activity, hydrolytic mechanism 1/1291 12/18639 0.0833333333333333 1.20313710302091 0.577519010487466 0.857483809987735 GO:1990817 poly(A) RNA polymerase activity 1/1291 12/18639 0.0833333333333333 1.20313710302091 0.577519010487466 0.857483809987735 GO:0005245 voltage-gated calcium channel activity 3/1291 43/18639 0.0697674418604651 1.00727757462216 0.580121473158458 0.859167245057463 GO:0008375 acetylglucosaminyltransferase activity 3/1291 43/18639 0.0697674418604651 1.00727757462216 0.580121473158458 0.859167245057463 GO:0016866 intramolecular transferase activity 2/1291 28/18639 0.0714285714285714 1.03126037401793 0.586930110338444 0.861006780022096 GO:0046625 sphingolipid binding 2/1291 28/18639 0.0714285714285714 1.03126037401793 0.586930110338444 0.861006780022096 GO:0051019 mitogen-activated protein kinase binding 2/1291 28/18639 0.0714285714285714 1.03126037401793 0.586930110338444 0.861006780022096 GO:0051119 sugar transmembrane transporter activity 2/1291 28/18639 0.0714285714285714 1.03126037401793 0.586930110338444 0.861006780022096 GO:0051393 alpha-actinin binding 2/1291 28/18639 0.0714285714285714 1.03126037401793 0.586930110338444 0.861006780022096 GO:0051537 2 iron, 2 sulfur cluster binding 2/1291 28/18639 0.0714285714285714 1.03126037401793 0.586930110338444 0.861006780022096 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 2/1291 28/18639 0.0714285714285714 1.03126037401793 0.586930110338444 0.861006780022096 GO:0051087 protein-folding chaperone binding 9/1291 134/18639 0.0671641791044776 0.969692590494468 0.587250778168916 0.861006780022096 GO:0031491 nucleosome binding 5/1291 74/18639 0.0675675675675676 0.975516570016957 0.588545937361038 0.861597542141726 GO:0015459 potassium channel regulator activity 4/1291 59/18639 0.0677966101694915 0.978823405847523 0.591044147664397 0.861597542141726 GO:0004518 nuclease activity 14/1291 209/18639 0.0669856459330144 0.967114991901979 0.591302101270254 0.861597542141726 GO:0004540 RNA nuclease activity 8/1291 121/18639 0.0661157024793388 0.954555056942213 0.605992036967802 0.861597542141726 GO:0003785 actin monomer binding 2/1291 29/18639 0.0689655172413793 0.995699671465584 0.606286562190509 0.861597542141726 GO:0004181 metallocarboxypeptidase activity 2/1291 29/18639 0.0689655172413793 0.995699671465584 0.606286562190509 0.861597542141726 GO:0051861 glycolipid binding 2/1291 29/18639 0.0689655172413793 0.995699671465584 0.606286562190509 0.861597542141726 GO:0004465 lipoprotein lipase activity 1/1291 13/18639 0.0769230769230769 1.11058809509623 0.606800320277592 0.861597542141726 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 1/1291 13/18639 0.0769230769230769 1.11058809509623 0.606800320277592 0.861597542141726 GO:0004993 G protein-coupled serotonin receptor activity 1/1291 13/18639 0.0769230769230769 1.11058809509623 0.606800320277592 0.861597542141726 GO:0005035 death receptor activity 1/1291 13/18639 0.0769230769230769 1.11058809509623 0.606800320277592 0.861597542141726 GO:0008035 high-density lipoprotein particle binding 1/1291 13/18639 0.0769230769230769 1.11058809509623 0.606800320277592 0.861597542141726 GO:0008417 fucosyltransferase activity 1/1291 13/18639 0.0769230769230769 1.11058809509623 0.606800320277592 0.861597542141726 GO:0009982 pseudouridine synthase activity 1/1291 13/18639 0.0769230769230769 1.11058809509623 0.606800320277592 0.861597542141726 GO:0015651 quaternary ammonium group transmembrane transporter activity 1/1291 13/18639 0.0769230769230769 1.11058809509623 0.606800320277592 0.861597542141726 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 1/1291 13/18639 0.0769230769230769 1.11058809509623 0.606800320277592 0.861597542141726 GO:0017154 semaphorin receptor activity 1/1291 13/18639 0.0769230769230769 1.11058809509623 0.606800320277592 0.861597542141726 GO:0019855 calcium channel inhibitor activity 1/1291 13/18639 0.0769230769230769 1.11058809509623 0.606800320277592 0.861597542141726 GO:0031994 insulin-like growth factor I binding 1/1291 13/18639 0.0769230769230769 1.11058809509623 0.606800320277592 0.861597542141726 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 1/1291 13/18639 0.0769230769230769 1.11058809509623 0.606800320277592 0.861597542141726 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 1/1291 13/18639 0.0769230769230769 1.11058809509623 0.606800320277592 0.861597542141726 GO:0061459 L-arginine transmembrane transporter activity 1/1291 13/18639 0.0769230769230769 1.11058809509623 0.606800320277592 0.861597542141726 GO:0071837 HMG box domain binding 1/1291 13/18639 0.0769230769230769 1.11058809509623 0.606800320277592 0.861597542141726 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 1/1291 13/18639 0.0769230769230769 1.11058809509623 0.606800320277592 0.861597542141726 GO:0140410 monoatomic cation:bicarbonate symporter activity 1/1291 13/18639 0.0769230769230769 1.11058809509623 0.606800320277592 0.861597542141726 GO:0140666 annealing activity 1/1291 13/18639 0.0769230769230769 1.11058809509623 0.606800320277592 0.861597542141726 GO:0046915 transition metal ion transmembrane transporter activity 3/1291 45/18639 0.0666666666666667 0.962509682416731 0.611395377997871 0.86706980879698 GO:0098631 cell adhesion mediator activity 5/1291 76/18639 0.0657894736842105 0.949845081332301 0.612508036988908 0.867596129875329 GO:0052689 carboxylic ester hydrolase activity 6/1291 92/18639 0.0652173913043478 0.941585558885933 0.620013481392557 0.869686737724216 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 2/1291 30/18639 0.0666666666666667 0.962509682416731 0.624945731556746 0.869686737724216 GO:0051721 protein phosphatase 2A binding 2/1291 30/18639 0.0666666666666667 0.962509682416731 0.624945731556746 0.869686737724216 GO:0004180 carboxypeptidase activity 3/1291 46/18639 0.0652173913043478 0.941585558885933 0.626433718079551 0.869686737724216 GO:0030276 clathrin binding 3/1291 46/18639 0.0652173913043478 0.941585558885933 0.626433718079551 0.869686737724216 GO:0005506 iron ion binding 10/1291 154/18639 0.0649350649350649 0.937509430925387 0.629933473037843 0.869686737724216 GO:0015179 L-amino acid transmembrane transporter activity 4/1291 62/18639 0.0645161290322581 0.931460982983933 0.630594382055311 0.869686737724216 GO:0005085 guanyl-nucleotide exchange factor activity 15/1291 230/18639 0.0652173913043478 0.941585558885933 0.633657535467163 0.869686737724216 GO:0004705 JUN kinase activity 1/1291 14/18639 0.0714285714285714 1.03126037401793 0.634053664340817 0.869686737724216 GO:0005545 1-phosphatidylinositol binding 1/1291 14/18639 0.0714285714285714 1.03126037401793 0.634053664340817 0.869686737724216 GO:0008191 metalloendopeptidase inhibitor activity 1/1291 14/18639 0.0714285714285714 1.03126037401793 0.634053664340817 0.869686737724216 GO:0008559 ABC-type xenobiotic transporter activity 1/1291 14/18639 0.0714285714285714 1.03126037401793 0.634053664340817 0.869686737724216 GO:0015926 glucosidase activity 1/1291 14/18639 0.0714285714285714 1.03126037401793 0.634053664340817 0.869686737724216 GO:0016530 metallochaperone activity 1/1291 14/18639 0.0714285714285714 1.03126037401793 0.634053664340817 0.869686737724216 GO:0030983 mismatched DNA binding 1/1291 14/18639 0.0714285714285714 1.03126037401793 0.634053664340817 0.869686737724216 GO:0031404 chloride ion binding 1/1291 14/18639 0.0714285714285714 1.03126037401793 0.634053664340817 0.869686737724216 GO:0032454 histone H3K9 demethylase activity 1/1291 14/18639 0.0714285714285714 1.03126037401793 0.634053664340817 0.869686737724216 GO:0042043 neurexin family protein binding 1/1291 14/18639 0.0714285714285714 1.03126037401793 0.634053664340817 0.869686737724216 GO:0042813 Wnt receptor activity 1/1291 14/18639 0.0714285714285714 1.03126037401793 0.634053664340817 0.869686737724216 GO:0043176 amine binding 1/1291 14/18639 0.0714285714285714 1.03126037401793 0.634053664340817 0.869686737724216 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 1/1291 14/18639 0.0714285714285714 1.03126037401793 0.634053664340817 0.869686737724216 GO:0061665 SUMO ligase activity 1/1291 14/18639 0.0714285714285714 1.03126037401793 0.634053664340817 0.869686737724216 GO:0061783 peptidoglycan muralytic activity 1/1291 14/18639 0.0714285714285714 1.03126037401793 0.634053664340817 0.869686737724216 GO:0071933 Arp2/3 complex binding 1/1291 14/18639 0.0714285714285714 1.03126037401793 0.634053664340817 0.869686737724216 GO:0098847 sequence-specific single stranded DNA binding 1/1291 14/18639 0.0714285714285714 1.03126037401793 0.634053664340817 0.869686737724216 GO:1901612 cardiolipin binding 1/1291 14/18639 0.0714285714285714 1.03126037401793 0.634053664340817 0.869686737724216 GO:1990825 sequence-specific mRNA binding 1/1291 14/18639 0.0714285714285714 1.03126037401793 0.634053664340817 0.869686737724216 GO:0005164 tumor necrosis factor receptor binding 2/1291 31/18639 0.0645161290322581 0.931460982983933 0.642911277339556 0.878745554307571 GO:0016411 acylglycerol O-acyltransferase activity 2/1291 31/18639 0.0645161290322581 0.931460982983933 0.642911277339556 0.878745554307571 GO:0016878 acid-thiol ligase activity 2/1291 31/18639 0.0645161290322581 0.931460982983933 0.642911277339556 0.878745554307571 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 3/1291 48/18639 0.0625 0.902352827265686 0.655290876236023 0.879751643762413 GO:0016879 ligase activity, forming carbon-nitrogen bonds 3/1291 48/18639 0.0625 0.902352827265686 0.655290876236023 0.879751643762413 GO:0048306 calcium-dependent protein binding 5/1291 80/18639 0.0625 0.902352827265686 0.657894584555153 0.879751643762413 GO:0004129 cytochrome-c oxidase activity 1/1291 15/18639 0.0666666666666667 0.962509682416731 0.659419394238052 0.879751643762413 GO:0004467 long-chain fatty acid-CoA ligase activity 1/1291 15/18639 0.0666666666666667 0.962509682416731 0.659419394238052 0.879751643762413 GO:0005041 low-density lipoprotein particle receptor activity 1/1291 15/18639 0.0666666666666667 0.962509682416731 0.659419394238052 0.879751643762413 GO:0016846 carbon-sulfur lyase activity 1/1291 15/18639 0.0666666666666667 0.962509682416731 0.659419394238052 0.879751643762413 GO:0031005 filamin binding 1/1291 15/18639 0.0666666666666667 0.962509682416731 0.659419394238052 0.879751643762413 GO:0031386 protein tag activity 1/1291 15/18639 0.0666666666666667 0.962509682416731 0.659419394238052 0.879751643762413 GO:0033130 acetylcholine receptor binding 1/1291 15/18639 0.0666666666666667 0.962509682416731 0.659419394238052 0.879751643762413 GO:0050700 CARD domain binding 1/1291 15/18639 0.0666666666666667 0.962509682416731 0.659419394238052 0.879751643762413 GO:0050780 dopamine receptor binding 1/1291 15/18639 0.0666666666666667 0.962509682416731 0.659419394238052 0.879751643762413 GO:0055105 ubiquitin-protein transferase inhibitor activity 1/1291 15/18639 0.0666666666666667 0.962509682416731 0.659419394238052 0.879751643762413 GO:0141047 molecular tag activity 1/1291 15/18639 0.0666666666666667 0.962509682416731 0.659419394238052 0.879751643762413 GO:0141050 histone H3K deacetylase activity 1/1291 15/18639 0.0666666666666667 0.962509682416731 0.659419394238052 0.879751643762413 GO:0141051 histone H4K deacetylase activity 1/1291 15/18639 0.0666666666666667 0.962509682416731 0.659419394238052 0.879751643762413 GO:0015106 bicarbonate transmembrane transporter activity 2/1291 32/18639 0.0625 0.902352827265686 0.660189695062734 0.879751643762413 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 2/1291 32/18639 0.0625 0.902352827265686 0.660189695062734 0.879751643762413 GO:0042910 xenobiotic transmembrane transporter activity 2/1291 32/18639 0.0625 0.902352827265686 0.660189695062734 0.879751643762413 GO:0051059 NF-kappaB binding 2/1291 32/18639 0.0625 0.902352827265686 0.660189695062734 0.879751643762413 GO:0071813 lipoprotein particle binding 2/1291 32/18639 0.0625 0.902352827265686 0.660189695062734 0.879751643762413 GO:0071814 protein-lipid complex binding 2/1291 32/18639 0.0625 0.902352827265686 0.660189695062734 0.879751643762413 GO:0043022 ribosome binding 7/1291 112/18639 0.0625 0.902352827265686 0.664994253344982 0.885145934486494 GO:0003823 antigen binding 11/1291 174/18639 0.0632183908045977 0.912724698843452 0.666873519633653 0.886638656785652 GO:0035254 glutamate receptor binding 3/1291 49/18639 0.0612244897959184 0.883937463443937 0.669105370610368 0.888596235657356 GO:0140416 transcription regulator inhibitor activity 2/1291 33/18639 0.0606060606060606 0.875008802197028 0.67678990694997 0.892897141286065 GO:0042626 ATPase-coupled transmembrane transporter activity 6/1291 98/18639 0.0612244897959184 0.883937463443937 0.680718193072874 0.892897141286065 GO:0000062 fatty-acyl-CoA binding 1/1291 16/18639 0.0625 0.902352827265686 0.683028155086349 0.892897141286065 GO:0003688 DNA replication origin binding 1/1291 16/18639 0.0625 0.902352827265686 0.683028155086349 0.892897141286065 GO:0004707 MAP kinase activity 1/1291 16/18639 0.0625 0.902352827265686 0.683028155086349 0.892897141286065 GO:0005324 long-chain fatty acid transmembrane transporter activity 1/1291 16/18639 0.0625 0.902352827265686 0.683028155086349 0.892897141286065 GO:0015378 sodium:chloride symporter activity 1/1291 16/18639 0.0625 0.902352827265686 0.683028155086349 0.892897141286065 GO:0016675 oxidoreductase activity, acting on a heme group of donors 1/1291 16/18639 0.0625 0.902352827265686 0.683028155086349 0.892897141286065 GO:0016722 oxidoreductase activity, acting on metal ions 1/1291 16/18639 0.0625 0.902352827265686 0.683028155086349 0.892897141286065 GO:0017070 U6 snRNA binding 1/1291 16/18639 0.0625 0.902352827265686 0.683028155086349 0.892897141286065 GO:0031435 mitogen-activated protein kinase kinase kinase binding 1/1291 16/18639 0.0625 0.902352827265686 0.683028155086349 0.892897141286065 GO:0055102 lipase inhibitor activity 1/1291 16/18639 0.0625 0.902352827265686 0.683028155086349 0.892897141286065 GO:0097027 ubiquitin-protein transferase activator activity 1/1291 16/18639 0.0625 0.902352827265686 0.683028155086349 0.892897141286065 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 1/1291 16/18639 0.0625 0.902352827265686 0.683028155086349 0.892897141286065 GO:0004866 endopeptidase inhibitor activity 10/1291 161/18639 0.062111801242236 0.896748151319936 0.684856107206679 0.894287550705151 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 4/1291 67/18639 0.0597014925373134 0.861948969328416 0.690814026479003 0.896578066231169 GO:0008175 tRNA methyltransferase activity 2/1291 34/18639 0.0588235294117647 0.849273249191233 0.692722895107843 0.896578066231169 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 2/1291 34/18639 0.0588235294117647 0.849273249191233 0.692722895107843 0.896578066231169 GO:0030332 cyclin binding 2/1291 34/18639 0.0588235294117647 0.849273249191233 0.692722895107843 0.896578066231169 GO:0030544 Hsp70 protein binding 3/1291 51/18639 0.0588235294117647 0.849273249191233 0.695505388132475 0.896578066231169 GO:0003777 microtubule motor activity 4/1291 68/18639 0.0588235294117647 0.849273249191233 0.701980143978597 0.896578066231169 GO:0015291 secondary active transmembrane transporter activity 18/1291 287/18639 0.0627177700348432 0.905496913771838 0.703434481205074 0.896578066231169 GO:0004549 tRNA-specific ribonuclease activity 1/1291 17/18639 0.0588235294117647 0.849273249191233 0.705001556352714 0.896578066231169 GO:0004550 nucleoside diphosphate kinase activity 1/1291 17/18639 0.0588235294117647 0.849273249191233 0.705001556352714 0.896578066231169 GO:0004659 prenyltransferase activity 1/1291 17/18639 0.0588235294117647 0.849273249191233 0.705001556352714 0.896578066231169 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 1/1291 17/18639 0.0588235294117647 0.849273249191233 0.705001556352714 0.896578066231169 GO:0005092 GDP-dissociation inhibitor activity 1/1291 17/18639 0.0588235294117647 0.849273249191233 0.705001556352714 0.896578066231169 GO:0008429 phosphatidylethanolamine binding 1/1291 17/18639 0.0588235294117647 0.849273249191233 0.705001556352714 0.896578066231169 GO:0008484 sulfuric ester hydrolase activity 1/1291 17/18639 0.0588235294117647 0.849273249191233 0.705001556352714 0.896578066231169 GO:0008569 minus-end-directed microtubule motor activity 1/1291 17/18639 0.0588235294117647 0.849273249191233 0.705001556352714 0.896578066231169 GO:0016018 cyclosporin A binding 1/1291 17/18639 0.0588235294117647 0.849273249191233 0.705001556352714 0.896578066231169 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 1/1291 17/18639 0.0588235294117647 0.849273249191233 0.705001556352714 0.896578066231169 GO:0030548 acetylcholine receptor regulator activity 1/1291 17/18639 0.0588235294117647 0.849273249191233 0.705001556352714 0.896578066231169 GO:0032183 SUMO binding 1/1291 17/18639 0.0588235294117647 0.849273249191233 0.705001556352714 0.896578066231169 GO:0032977 membrane insertase activity 1/1291 17/18639 0.0588235294117647 0.849273249191233 0.705001556352714 0.896578066231169 GO:0038191 neuropilin binding 1/1291 17/18639 0.0588235294117647 0.849273249191233 0.705001556352714 0.896578066231169 GO:0045236 CXCR chemokine receptor binding 1/1291 17/18639 0.0588235294117647 0.849273249191233 0.705001556352714 0.896578066231169 GO:0051787 misfolded protein binding 1/1291 17/18639 0.0588235294117647 0.849273249191233 0.705001556352714 0.896578066231169 GO:1901567 fatty acid derivative binding 1/1291 17/18639 0.0588235294117647 0.849273249191233 0.705001556352714 0.896578066231169 GO:0016229 steroid dehydrogenase activity 2/1291 35/18639 0.0571428571428571 0.825008299214341 0.708001373815942 0.896612670891167 GO:0034061 DNA polymerase activity 2/1291 35/18639 0.0571428571428571 0.825008299214341 0.708001373815942 0.896612670891167 GO:0005080 protein kinase C binding 3/1291 52/18639 0.0576923076923077 0.832941071322171 0.708094109319178 0.896612670891167 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 3/1291 52/18639 0.0576923076923077 0.832941071322171 0.708094109319178 0.896612670891167 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 11/1291 181/18639 0.0607734806629834 0.877425953584313 0.716266363402332 0.90104009734532 GO:0015171 amino acid transmembrane transporter activity 6/1291 102/18639 0.0588235294117647 0.849273249191233 0.717501816564565 0.90104009734532 GO:0019842 vitamin binding 9/1291 150/18639 0.06 0.866258714175058 0.719190284789153 0.90104009734532 GO:0016251 RNA polymerase II general transcription initiation factor activity 3/1291 53/18639 0.0566037735849057 0.817225202051942 0.720279140756265 0.90104009734532 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 3/1291 53/18639 0.0566037735849057 0.817225202051942 0.720279140756265 0.90104009734532 GO:0045505 dynein intermediate chain binding 2/1291 36/18639 0.0555555555555556 0.802091402013943 0.722639497273067 0.90104009734532 GO:0055106 ubiquitin-protein transferase regulator activity 2/1291 36/18639 0.0555555555555556 0.802091402013943 0.722639497273067 0.90104009734532 GO:0000900 mRNA regulatory element binding translation repressor activity 1/1291 18/18639 0.0555555555555556 0.802091402013943 0.725452796324181 0.90104009734532 GO:0008525 phosphatidylcholine transporter activity 1/1291 18/18639 0.0555555555555556 0.802091402013943 0.725452796324181 0.90104009734532 GO:0015373 monoatomic anion:sodium symporter activity 1/1291 18/18639 0.0555555555555556 0.802091402013943 0.725452796324181 0.90104009734532 GO:0016854 racemase and epimerase activity 1/1291 18/18639 0.0555555555555556 0.802091402013943 0.725452796324181 0.90104009734532 GO:0017075 syntaxin-1 binding 1/1291 18/18639 0.0555555555555556 0.802091402013943 0.725452796324181 0.90104009734532 GO:0022851 GABA-gated chloride ion channel activity 1/1291 18/18639 0.0555555555555556 0.802091402013943 0.725452796324181 0.90104009734532 GO:0030228 lipoprotein particle receptor activity 1/1291 18/18639 0.0555555555555556 0.802091402013943 0.725452796324181 0.90104009734532 GO:0050811 GABA receptor binding 1/1291 18/18639 0.0555555555555556 0.802091402013943 0.725452796324181 0.90104009734532 GO:0070628 proteasome binding 1/1291 18/18639 0.0555555555555556 0.802091402013943 0.725452796324181 0.90104009734532 GO:0099602 neurotransmitter receptor regulator activity 1/1291 18/18639 0.0555555555555556 0.802091402013943 0.725452796324181 0.90104009734532 GO:1901611 phosphatidylglycerol binding 1/1291 18/18639 0.0555555555555556 0.802091402013943 0.725452796324181 0.90104009734532 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 3/1291 54/18639 0.0555555555555556 0.802091402013943 0.73206448594686 0.903578915806515 GO:0016247 channel regulator activity 10/1291 168/18639 0.0595238095238095 0.859383645014938 0.73455346573335 0.903578915806515 GO:0019213 deacetylase activity 2/1291 37/18639 0.0540540540540541 0.780413256013566 0.736652599465985 0.903578915806515 GO:0030551 cyclic nucleotide binding 2/1291 37/18639 0.0540540540540541 0.780413256013566 0.736652599465985 0.903578915806515 GO:0004197 cysteine-type endopeptidase activity 5/1291 88/18639 0.0568181818181818 0.820320752059714 0.737852752370547 0.903578915806515 GO:0003756 protein disulfide isomerase activity 1/1291 19/18639 0.0526315789473684 0.75987606506584 0.744487243450838 0.903578915806515 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 1/1291 19/18639 0.0526315789473684 0.75987606506584 0.744487243450838 0.903578915806515 GO:0004890 GABA-A receptor activity 1/1291 19/18639 0.0526315789473684 0.75987606506584 0.744487243450838 0.903578915806515 GO:0005229 intracellularly calcium-gated chloride channel activity 1/1291 19/18639 0.0526315789473684 0.75987606506584 0.744487243450838 0.903578915806515 GO:0005520 insulin-like growth factor binding 1/1291 19/18639 0.0526315789473684 0.75987606506584 0.744487243450838 0.903578915806515 GO:0008301 DNA binding, bending 1/1291 19/18639 0.0526315789473684 0.75987606506584 0.744487243450838 0.903578915806515 GO:0008574 plus-end-directed microtubule motor activity 1/1291 19/18639 0.0526315789473684 0.75987606506584 0.744487243450838 0.903578915806515 GO:0015245 fatty acid transmembrane transporter activity 1/1291 19/18639 0.0526315789473684 0.75987606506584 0.744487243450838 0.903578915806515 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 1/1291 19/18639 0.0526315789473684 0.75987606506584 0.744487243450838 0.903578915806515 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 1/1291 19/18639 0.0526315789473684 0.75987606506584 0.744487243450838 0.903578915806515 GO:0050145 nucleoside monophosphate kinase activity 1/1291 19/18639 0.0526315789473684 0.75987606506584 0.744487243450838 0.903578915806515 GO:0070003 threonine-type peptidase activity 1/1291 19/18639 0.0526315789473684 0.75987606506584 0.744487243450838 0.903578915806515 GO:0097001 ceramide binding 1/1291 19/18639 0.0526315789473684 0.75987606506584 0.744487243450838 0.903578915806515 GO:0099589 serotonin receptor activity 1/1291 19/18639 0.0526315789473684 0.75987606506584 0.744487243450838 0.903578915806515 GO:0120227 acyl-CoA binding 1/1291 19/18639 0.0526315789473684 0.75987606506584 0.744487243450838 0.903578915806515 GO:0140036 ubiquitin-modified protein reader activity 1/1291 19/18639 0.0526315789473684 0.75987606506584 0.744487243450838 0.903578915806515 GO:0141147 intracellularly calcium-gated channel activity 1/1291 19/18639 0.0526315789473684 0.75987606506584 0.744487243450838 0.903578915806515 GO:0141108 transporter regulator activity 10/1291 170/18639 0.0588235294117647 0.849273249191233 0.747746547237685 0.906104915458026 GO:0030246 carbohydrate binding 17/1291 280/18639 0.0607142857142857 0.876571317915237 0.748117391737139 0.906104915458026 GO:0042162 telomeric DNA binding 2/1291 38/18639 0.0526315789473684 0.75987606506584 0.750056963118403 0.906559508596249 GO:0005125 cytokine activity 14/1291 234/18639 0.0598290598290598 0.8637907406304 0.752660704778452 0.906559508596249 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 4/1291 73/18639 0.0547945205479452 0.791103848561697 0.753418934589479 0.906559508596249 GO:0019212 phosphatase inhibitor activity 3/1291 56/18639 0.0535714285714286 0.773445280513445 0.75445599021727 0.906559508596249 GO:0030170 pyridoxal phosphate binding 3/1291 56/18639 0.0535714285714286 0.773445280513445 0.75445599021727 0.906559508596249 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 3/1291 56/18639 0.0535714285714286 0.773445280513445 0.75445599021727 0.906559508596249 GO:0004175 endopeptidase activity 25/1291 405/18639 0.0617283950617284 0.891212668904381 0.754560812893351 0.906559508596249 GO:0008234 cysteine-type peptidase activity 11/1291 187/18639 0.0588235294117647 0.849273249191233 0.754691419976706 0.906559508596249 GO:0046943 carboxylic acid transmembrane transporter activity 11/1291 188/18639 0.0585106382978723 0.84475583829128 0.760735774541267 0.907993336200624 GO:0000339 RNA cap binding 1/1291 20/18639 0.05 0.721882261812548 0.762202977538108 0.907993336200624 GO:0001972 retinoic acid binding 1/1291 20/18639 0.05 0.721882261812548 0.762202977538108 0.907993336200624 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 1/1291 20/18639 0.05 0.721882261812548 0.762202977538108 0.907993336200624 GO:0061608 nuclear import signal receptor activity 1/1291 20/18639 0.05 0.721882261812548 0.762202977538108 0.907993336200624 GO:0140664 ATP-dependent DNA damage sensor activity 1/1291 20/18639 0.05 0.721882261812548 0.762202977538108 0.907993336200624 GO:0048029 monosaccharide binding 4/1291 74/18639 0.0540540540540541 0.780413256013566 0.762840248716818 0.907993336200624 GO:0016776 phosphotransferase activity, phosphate group as acceptor 2/1291 39/18639 0.0512820512820513 0.740392063397486 0.762869614944626 0.907993336200624 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 2/1291 39/18639 0.0512820512820513 0.740392063397486 0.762869614944626 0.907993336200624 GO:0070279 vitamin B6 binding 3/1291 57/18639 0.0526315789473684 0.75987606506584 0.765073758663989 0.90969135938706 GO:0005342 organic acid transmembrane transporter activity 11/1291 189/18639 0.0582010582010582 0.840286230681273 0.766676827977937 0.910671968258057 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 2/1291 40/18639 0.05 0.721882261812548 0.775108144676922 0.917491252229973 GO:0071949 FAD binding 2/1291 40/18639 0.05 0.721882261812548 0.775108144676922 0.917491252229973 GO:0140662 ATP-dependent protein folding chaperone 2/1291 40/18639 0.05 0.721882261812548 0.775108144676922 0.917491252229973 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 1/1291 21/18639 0.0476190476190476 0.687506916011951 0.778691293559285 0.917491252229973 GO:0019200 carbohydrate kinase activity 1/1291 21/18639 0.0476190476190476 0.687506916011951 0.778691293559285 0.917491252229973 GO:0035613 RNA stem-loop binding 1/1291 21/18639 0.0476190476190476 0.687506916011951 0.778691293559285 0.917491252229973 GO:0051428 peptide hormone receptor binding 1/1291 21/18639 0.0476190476190476 0.687506916011951 0.778691293559285 0.917491252229973 GO:0072542 protein phosphatase activator activity 1/1291 21/18639 0.0476190476190476 0.687506916011951 0.778691293559285 0.917491252229973 GO:0051219 phosphoprotein binding 5/1291 93/18639 0.0537634408602151 0.776217485819945 0.780378478205084 0.918554144366145 GO:0045309 protein phosphorylated amino acid binding 3/1291 59/18639 0.0508474576271186 0.734117554385643 0.785186548819359 0.920544938304702 GO:0070063 RNA polymerase binding 3/1291 59/18639 0.0508474576271186 0.734117554385643 0.785186548819359 0.920544938304702 GO:0099106 ion channel regulator activity 9/1291 160/18639 0.05625 0.812117544539117 0.785951811613961 0.920544938304702 GO:0001530 lipopolysaccharide binding 2/1291 41/18639 0.0487804878048781 0.704275377378096 0.786790545559574 0.920544938304702 GO:0015175 neutral L-amino acid transmembrane transporter activity 2/1291 41/18639 0.0487804878048781 0.704275377378096 0.786790545559574 0.920544938304702 GO:0016877 ligase activity, forming carbon-sulfur bonds 2/1291 41/18639 0.0487804878048781 0.704275377378096 0.786790545559574 0.920544938304702 GO:0005243 gap junction channel activity 1/1291 22/18639 0.0454545454545455 0.656256601647771 0.794037170668264 0.921655480517167 GO:0008649 rRNA methyltransferase activity 1/1291 22/18639 0.0454545454545455 0.656256601647771 0.794037170668264 0.921655480517167 GO:0008970 phospholipase A1 activity 1/1291 22/18639 0.0454545454545455 0.656256601647771 0.794037170668264 0.921655480517167 GO:0015377 chloride:monoatomic cation symporter activity 1/1291 22/18639 0.0454545454545455 0.656256601647771 0.794037170668264 0.921655480517167 GO:0030021 extracellular matrix structural constituent conferring compression resistance 1/1291 22/18639 0.0454545454545455 0.656256601647771 0.794037170668264 0.921655480517167 GO:0140517 protein-RNA adaptor activity 1/1291 22/18639 0.0454545454545455 0.656256601647771 0.794037170668264 0.921655480517167 GO:0031492 nucleosomal DNA binding 2/1291 42/18639 0.0476190476190476 0.687506916011951 0.797935074207804 0.921655480517167 GO:0015293 symporter activity 8/1291 146/18639 0.0547945205479452 0.791103848561697 0.800477141438651 0.921655480517167 GO:0016835 carbon-oxygen lyase activity 4/1291 79/18639 0.0506329113924051 0.731020011962074 0.805781160213996 0.921655480517167 GO:0033293 monocarboxylic acid binding 4/1291 79/18639 0.0506329113924051 0.731020011962074 0.805781160213996 0.921655480517167 GO:0016853 isomerase activity 10/1291 180/18639 0.0555555555555556 0.802091402013943 0.806921677543123 0.921655480517167 GO:0004022 alcohol dehydrogenase (NAD+) activity 1/1291 23/18639 0.0434782608695652 0.627723705923955 0.808319708814435 0.921655480517167 GO:0004602 glutathione peroxidase activity 1/1291 23/18639 0.0434782608695652 0.627723705923955 0.808319708814435 0.921655480517167 GO:0005283 amino acid:sodium symporter activity 1/1291 23/18639 0.0434782608695652 0.627723705923955 0.808319708814435 0.921655480517167 GO:0008171 O-methyltransferase activity 1/1291 23/18639 0.0434782608695652 0.627723705923955 0.808319708814435 0.921655480517167 GO:0016493 C-C chemokine receptor activity 1/1291 23/18639 0.0434782608695652 0.627723705923955 0.808319708814435 0.921655480517167 GO:0016917 GABA receptor activity 1/1291 23/18639 0.0434782608695652 0.627723705923955 0.808319708814435 0.921655480517167 GO:0017134 fibroblast growth factor binding 1/1291 23/18639 0.0434782608695652 0.627723705923955 0.808319708814435 0.921655480517167 GO:0042171 lysophosphatidic acid acyltransferase activity 1/1291 23/18639 0.0434782608695652 0.627723705923955 0.808319708814435 0.921655480517167 GO:0043274 phospholipase binding 1/1291 23/18639 0.0434782608695652 0.627723705923955 0.808319708814435 0.921655480517167 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 1/1291 23/18639 0.0434782608695652 0.627723705923955 0.808319708814435 0.921655480517167 GO:0071617 lysophospholipid acyltransferase activity 1/1291 23/18639 0.0434782608695652 0.627723705923955 0.808319708814435 0.921655480517167 GO:0140102 catalytic activity, acting on a rRNA 1/1291 23/18639 0.0434782608695652 0.627723705923955 0.808319708814435 0.921655480517167 GO:0008200 ion channel inhibitor activity 2/1291 43/18639 0.0465116279069767 0.67151838308144 0.808560127917528 0.921655480517167 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 2/1291 43/18639 0.0465116279069767 0.67151838308144 0.808560127917528 0.921655480517167 GO:0003954 NADH dehydrogenase activity 2/1291 44/18639 0.0454545454545455 0.656256601647771 0.818684137683876 0.921655480517167 GO:0016248 channel inhibitor activity 2/1291 44/18639 0.0454545454545455 0.656256601647771 0.818684137683876 0.921655480517167 GO:0015399 primary active transmembrane transporter activity 9/1291 166/18639 0.0542168674698795 0.782763898350956 0.820022152505525 0.921655480517167 GO:0005507 copper ion binding 3/1291 63/18639 0.0476190476190476 0.687506916011951 0.821133745655007 0.921655480517167 GO:0022824 transmitter-gated monoatomic ion channel activity 3/1291 63/18639 0.0476190476190476 0.687506916011951 0.821133745655007 0.921655480517167 GO:0022835 transmitter-gated channel activity 3/1291 63/18639 0.0476190476190476 0.687506916011951 0.821133745655007 0.921655480517167 GO:1901682 sulfur compound transmembrane transporter activity 3/1291 63/18639 0.0476190476190476 0.687506916011951 0.821133745655007 0.921655480517167 GO:0004622 lysophospholipase activity 1/1291 24/18639 0.0416666666666667 0.601568551510457 0.821612535196073 0.921655480517167 GO:0005540 hyaluronic acid binding 1/1291 24/18639 0.0416666666666667 0.601568551510457 0.821612535196073 0.921655480517167 GO:0019957 C-C chemokine binding 1/1291 24/18639 0.0416666666666667 0.601568551510457 0.821612535196073 0.921655480517167 GO:0030215 semaphorin receptor binding 1/1291 24/18639 0.0416666666666667 0.601568551510457 0.821612535196073 0.921655480517167 GO:0042625 ATPase-coupled ion transmembrane transporter activity 1/1291 24/18639 0.0416666666666667 0.601568551510457 0.821612535196073 0.921655480517167 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 1/1291 24/18639 0.0416666666666667 0.601568551510457 0.821612535196073 0.921655480517167 GO:0046961 proton-transporting ATPase activity, rotational mechanism 1/1291 24/18639 0.0416666666666667 0.601568551510457 0.821612535196073 0.921655480517167 GO:0048027 mRNA 5'-UTR binding 1/1291 24/18639 0.0416666666666667 0.601568551510457 0.821612535196073 0.921655480517167 GO:0070300 phosphatidic acid binding 1/1291 24/18639 0.0416666666666667 0.601568551510457 0.821612535196073 0.921655480517167 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 1/1291 24/18639 0.0416666666666667 0.601568551510457 0.821612535196073 0.921655480517167 GO:0140612 DNA damage sensor activity 1/1291 24/18639 0.0416666666666667 0.601568551510457 0.821612535196073 0.921655480517167 GO:0015294 solute:monoatomic cation symporter activity 6/1291 116/18639 0.0517241379310345 0.746774753599188 0.822523478309563 0.921793553277959 GO:0061135 endopeptidase regulator activity 10/1291 184/18639 0.0543478260869565 0.784654632404944 0.82747217063361 0.926452095350549 GO:0141110 transporter inhibitor activity 2/1291 45/18639 0.0444444444444444 0.641673121611154 0.82832547534369 0.926520847181757 GO:0022804 active transmembrane transporter activity 27/1291 457/18639 0.0590809628008753 0.852989981135178 0.831506875060623 0.926649091815845 GO:0005251 delayed rectifier potassium channel activity 1/1291 25/18639 0.04 0.577505809450039 0.833984182634261 0.926649091815845 GO:0005537 D-mannose binding 1/1291 25/18639 0.04 0.577505809450039 0.833984182634261 0.926649091815845 GO:0015662 P-type ion transporter activity 1/1291 25/18639 0.04 0.577505809450039 0.833984182634261 0.926649091815845 GO:0019211 phosphatase activator activity 1/1291 25/18639 0.04 0.577505809450039 0.833984182634261 0.926649091815845 GO:0047617 fatty acyl-CoA hydrolase activity 1/1291 25/18639 0.04 0.577505809450039 0.833984182634261 0.926649091815845 GO:0140358 P-type transmembrane transporter activity 1/1291 25/18639 0.04 0.577505809450039 0.833984182634261 0.926649091815845 GO:0160215 deacylase activity 3/1291 65/18639 0.0461538461538462 0.666352857057737 0.837100112000035 0.929228777077838 GO:0003774 cytoskeletal motor activity 8/1291 153/18639 0.0522875816993464 0.754909554836652 0.839456707672844 0.930538009197278 GO:0008514 organic anion transmembrane transporter activity 15/1291 269/18639 0.0557620817843866 0.805073154437786 0.841609261183051 0.930538009197278 GO:0001637 G protein-coupled chemoattractant receptor activity 1/1291 26/18639 0.0384615384615385 0.555294047548114 0.845498441805807 0.930538009197278 GO:0004950 chemokine receptor activity 1/1291 26/18639 0.0384615384615385 0.555294047548114 0.845498441805807 0.930538009197278 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 1/1291 26/18639 0.0384615384615385 0.555294047548114 0.845498441805807 0.930538009197278 GO:0016289 acyl-CoA hydrolase activity 1/1291 26/18639 0.0384615384615385 0.555294047548114 0.845498441805807 0.930538009197278 GO:0050681 nuclear androgen receptor binding 1/1291 26/18639 0.0384615384615385 0.555294047548114 0.845498441805807 0.930538009197278 GO:0001784 phosphotyrosine residue binding 2/1291 47/18639 0.0425531914893617 0.614367882393658 0.846232856227268 0.930538009197278 GO:0005504 fatty acid binding 2/1291 47/18639 0.0425531914893617 0.614367882393658 0.846232856227268 0.930538009197278 GO:0099095 ligand-gated monoatomic anion channel activity 2/1291 47/18639 0.0425531914893617 0.614367882393658 0.846232856227268 0.930538009197278 GO:0008173 RNA methyltransferase activity 3/1291 67/18639 0.0447761194029851 0.646461726996312 0.851821118251111 0.935803482022347 GO:0016209 antioxidant activity 4/1291 86/18639 0.0465116279069767 0.67151838308144 0.855037238281252 0.938455505430642 GO:0005104 fibroblast growth factor receptor binding 1/1291 27/18639 0.037037037037037 0.534727601342628 0.856214689139859 0.938867091184288 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 3/1291 68/18639 0.0441176470588235 0.636954936893425 0.858736855525227 0.939871020546787 GO:0140223 general transcription initiation factor activity 3/1291 68/18639 0.0441176470588235 0.636954936893425 0.858736855525227 0.939871020546787 GO:0098960 postsynaptic neurotransmitter receptor activity 3/1291 69/18639 0.0434782608695652 0.627723705923955 0.865367981879759 0.944492250427179 GO:0061134 peptidase regulator activity 12/1291 226/18639 0.0530973451327434 0.766600632013326 0.865512865484869 0.944492250427179 GO:0005242 inward rectifier potassium channel activity 1/1291 28/18639 0.0357142857142857 0.515630187008963 0.86618819205843 0.944492250427179 GO:0019789 SUMO transferase activity 1/1291 28/18639 0.0357142857142857 0.515630187008963 0.86618819205843 0.944492250427179 GO:0004252 serine-type endopeptidase activity 9/1291 176/18639 0.0511363636363636 0.738288676853743 0.867373097894551 0.944903654130935 GO:0032813 tumor necrosis factor receptor superfamily binding 2/1291 50/18639 0.04 0.577505809450039 0.869921766865092 0.94579903966428 GO:0008236 serine-type peptidase activity 10/1291 194/18639 0.0515463917525773 0.744208517332524 0.871496615037702 0.94579903966428 GO:0008028 monocarboxylic acid transmembrane transporter activity 3/1291 70/18639 0.0428571428571429 0.618756224410756 0.871723393569672 0.94579903966428 GO:0015079 potassium ion transmembrane transporter activity 8/1291 160/18639 0.05 0.721882261812548 0.872166930864071 0.94579903966428 GO:0022843 voltage-gated monoatomic cation channel activity 7/1291 143/18639 0.048951048951049 0.7067378786976 0.873737718307905 0.94579903966428 GO:0003730 mRNA 3'-UTR binding 14/1291 262/18639 0.0534351145038168 0.771477226364556 0.875394728637566 0.94579903966428 GO:0005416 amino acid:monoatomic cation symporter activity 1/1291 29/18639 0.0344827586206897 0.497849835732792 0.875470393125141 0.94579903966428 GO:0035250 UDP-galactosyltransferase activity 1/1291 29/18639 0.0344827586206897 0.497849835732792 0.875470393125141 0.94579903966428 GO:0106222 lncRNA binding 1/1291 29/18639 0.0344827586206897 0.497849835732792 0.875470393125141 0.94579903966428 GO:0015215 nucleotide transmembrane transporter activity 1/1291 30/18639 0.0333333333333333 0.481254841208366 0.884109174558534 0.952493309607261 GO:0033612 receptor serine/threonine kinase binding 1/1291 30/18639 0.0333333333333333 0.481254841208366 0.884109174558534 0.952493309607261 GO:0098918 structural constituent of synapse 1/1291 30/18639 0.0333333333333333 0.481254841208366 0.884109174558534 0.952493309607261 GO:0017171 serine hydrolase activity 10/1291 198/18639 0.0505050505050505 0.729174001830857 0.886361215888741 0.954041051140595 GO:0004864 protein phosphatase inhibitor activity 2/1291 53/18639 0.0377358490566038 0.544816801367961 0.890211201045171 0.954671957124519 GO:0005246 calcium channel regulator activity 2/1291 53/18639 0.0377358490566038 0.544816801367961 0.890211201045171 0.954671957124519 GO:0005544 calcium-dependent phospholipid binding 2/1291 53/18639 0.0377358490566038 0.544816801367961 0.890211201045171 0.954671957124519 GO:0016860 intramolecular oxidoreductase activity 2/1291 53/18639 0.0377358490566038 0.544816801367961 0.890211201045171 0.954671957124519 GO:0005452 solute:inorganic anion antiporter activity 1/1291 31/18639 0.032258064516129 0.465730491491967 0.892149104465834 0.954999498833509 GO:0072349 modified amino acid transmembrane transporter activity 1/1291 31/18639 0.032258064516129 0.465730491491967 0.892149104465834 0.954999498833509 GO:0016829 lyase activity 10/1291 200/18639 0.05 0.721882261812548 0.893247958138552 0.955301746820937 GO:0008378 galactosyltransferase activity 1/1291 32/18639 0.03125 0.451176413632843 0.899631666059482 0.958666029558939 GO:0030515 snoRNA binding 1/1291 32/18639 0.03125 0.451176413632843 0.899631666059482 0.958666029558939 GO:0031369 translation initiation factor binding 1/1291 32/18639 0.03125 0.451176413632843 0.899631666059482 0.958666029558939 GO:0044183 protein folding chaperone 3/1291 75/18639 0.04 0.577505809450039 0.899671196970697 0.958666029558939 GO:0015078 proton transmembrane transporter activity 9/1291 185/18639 0.0486486486486487 0.702371930412209 0.900874404822564 0.959074662094996 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 6/1291 132/18639 0.0454545454545455 0.656256601647771 0.901813866251898 0.959202021377019 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 1/1291 33/18639 0.0303030303030303 0.437504401098514 0.906595471031654 0.962537841294951 GO:0019956 chemokine binding 1/1291 33/18639 0.0303030303030303 0.437504401098514 0.906595471031654 0.962537841294951 GO:0030594 neurotransmitter receptor activity 4/1291 97/18639 0.0412371134020619 0.595366813866019 0.910855399209215 0.965291477261225 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 1/1291 34/18639 0.0294117647058824 0.424636624595617 0.913076458180861 0.965291477261225 GO:0019825 oxygen binding 1/1291 34/18639 0.0294117647058824 0.424636624595617 0.913076458180861 0.965291477261225 GO:0051427 hormone receptor binding 1/1291 34/18639 0.0294117647058824 0.424636624595617 0.913076458180861 0.965291477261225 GO:0043177 organic acid binding 9/1291 189/18639 0.0476190476190476 0.687506916011951 0.913314243870236 0.965291477261225 GO:0005249 voltage-gated potassium channel activity 4/1291 98/18639 0.0408163265306122 0.589291642295958 0.91483323989122 0.966024269560223 GO:0099094 ligand-gated monoatomic cation channel activity 6/1291 136/18639 0.0441176470588235 0.636954936893425 0.916067792598243 0.966455651343503 GO:0022853 active monoatomic ion transmembrane transporter activity 5/1291 118/18639 0.0423728813559322 0.611764628654702 0.91818380339745 0.96704716872465 GO:0005343 organic acid:sodium symporter activity 1/1291 35/18639 0.0285714285714286 0.41250414960717 0.91910807830924 0.96704716872465 GO:0140566 histone reader activity 1/1291 35/18639 0.0285714285714286 0.41250414960717 0.91910807830924 0.96704716872465 GO:0001786 phosphatidylserine binding 2/1291 59/18639 0.0338983050847458 0.489411702923762 0.922261817316831 0.969466053419757 GO:0004190 aspartic-type endopeptidase activity 1/1291 36/18639 0.0277777777777778 0.401045701006971 0.924721466338845 0.969466053419757 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 1/1291 36/18639 0.0277777777777778 0.401045701006971 0.924721466338845 0.969466053419757 GO:0005484 SNAP receptor activity 1/1291 36/18639 0.0277777777777778 0.401045701006971 0.924721466338845 0.969466053419757 GO:0030971 receptor tyrosine kinase binding 3/1291 81/18639 0.037037037037037 0.534727601342628 0.925888999371433 0.969821064695234 GO:0022829 wide pore channel activity 1/1291 37/18639 0.027027027027027 0.390206628006783 0.929945601529758 0.971778878865967 GO:0070001 aspartic-type peptidase activity 1/1291 37/18639 0.027027027027027 0.390206628006783 0.929945601529758 0.971778878865967 GO:0016836 hydro-lyase activity 2/1291 61/18639 0.0327868852459016 0.473365417581999 0.930823639940442 0.971778878865967 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 5/1291 122/18639 0.040983606557377 0.591706771977499 0.931080447186965 0.971778878865967 GO:0008135 translation factor activity, RNA binding 3/1291 83/18639 0.036144578313253 0.521842598900637 0.933125067084591 0.973044856050777 GO:0020037 heme binding 6/1291 142/18639 0.0422535211267606 0.610041348010604 0.934062846137576 0.97306470128798 GO:0000146 microfilament motor activity 1/1291 38/18639 0.0263157894736842 0.37993803253292 0.934807456621957 0.97306470128798 GO:0180051 translation factor activity 3/1291 84/18639 0.0357142857142857 0.515630187008963 0.936493623894695 0.973429744595374 GO:0005267 potassium channel activity 5/1291 124/18639 0.0403225806451613 0.582163114364958 0.936822130268711 0.973429744595374 GO:0019843 rRNA binding 2/1291 65/18639 0.0307692307692308 0.444235238038491 0.945341336013513 0.98141026010276 GO:0008137 NADH dehydrogenase (ubiquinone) activity 1/1291 41/18639 0.024390243902439 0.352137688689048 0.947461819822963 0.981554239066942 GO:0008227 G protein-coupled amine receptor activity 1/1291 41/18639 0.024390243902439 0.352137688689048 0.947461819822963 0.981554239066942 GO:0016874 ligase activity 7/1291 167/18639 0.0419161676646707 0.605170758405729 0.948699070569306 0.981554239066942 GO:0015276 ligand-gated monoatomic ion channel activity 8/1291 186/18639 0.043010752688172 0.620973988655956 0.949466693419999 0.981554239066942 GO:0004520 DNA endonuclease activity 1/1291 42/18639 0.0238095238095238 0.343753458005975 0.951108813618455 0.981554239066942 GO:0019894 kinesin binding 1/1291 42/18639 0.0238095238095238 0.343753458005975 0.951108813618455 0.981554239066942 GO:0031406 carboxylic acid binding 8/1291 187/18639 0.0427807486631016 0.617653272139079 0.951352570172574 0.981554239066942 GO:0022834 ligand-gated channel activity 8/1291 188/18639 0.0425531914893617 0.614367882393658 0.953175558815614 0.982014275506855 GO:0046873 metal ion transmembrane transporter activity 23/1291 450/18639 0.0511111111111111 0.737924089852827 0.953477108526314 0.982014275506855 GO:0072341 modified amino acid binding 3/1291 91/18639 0.032967032967033 0.475966326469812 0.956015117477187 0.983449286993361 GO:0046906 tetrapyrrole binding 6/1291 152/18639 0.0394736842105263 0.56990704879938 0.95655152871662 0.983449286993361 GO:0019205 nucleobase-containing compound kinase activity 1/1291 44/18639 0.0227272727272727 0.328128300823886 0.95766140418329 0.983725937571949 GO:0022836 gated channel activity 15/1291 318/18639 0.0471698113207547 0.681021001709951 0.959545230552123 0.984091361858086 GO:0005244 voltage-gated monoatomic ion channel activity 7/1291 173/18639 0.0404624277456647 0.584182177189346 0.959699353743655 0.984091361858086 GO:0140299 molecular sensor activity 2/1291 71/18639 0.028169014084507 0.40669423200707 0.961799161833961 0.985380927623235 GO:0022832 voltage-gated channel activity 7/1291 175/18639 0.04 0.577505809450039 0.962862746763996 0.985607536057634 GO:0004521 RNA endonuclease activity 2/1291 73/18639 0.0273972602739726 0.395551924280848 0.966139504274458 0.988097220280696 GO:0008188 neuropeptide receptor activity 1/1291 48/18639 0.0208333333333333 0.300784275755228 0.968251201903234 0.988528713984977 GO:0038187 pattern recognition receptor activity 1/1291 48/18639 0.0208333333333333 0.300784275755228 0.968251201903234 0.988528713984977 GO:0015108 chloride transmembrane transporter activity 4/1291 121/18639 0.0330578512396694 0.477277528471106 0.971808449998713 0.990431956880221 GO:0051082 unfolded protein binding 4/1291 121/18639 0.0330578512396694 0.477277528471106 0.971808449998713 0.990431956880221 GO:0015081 sodium ion transmembrane transporter activity 6/1291 164/18639 0.0365853658536585 0.528206533033572 0.974244318675347 0.99050203785164 GO:0003743 translation initiation factor activity 1/1291 51/18639 0.0196078431372549 0.283091083063744 0.97441696202328 0.99050203785164 GO:0016597 amino acid binding 1/1291 51/18639 0.0196078431372549 0.283091083063744 0.97441696202328 0.99050203785164 GO:0015103 inorganic anion transmembrane transporter activity 6/1291 165/18639 0.0363636363636364 0.525005281318217 0.975367652728327 0.990607772302207 GO:0015370 solute:sodium symporter activity 2/1291 79/18639 0.0253164556962025 0.365510005981037 0.97649509506555 0.990892681029222 GO:0004519 endonuclease activity 4/1291 127/18639 0.031496062992126 0.454728983818928 0.979190432769995 0.992328257485451 GO:0008509 monoatomic anion transmembrane transporter activity 5/1291 149/18639 0.0335570469798658 0.484484739471509 0.979952194670462 0.992328257485451 GO:0005261 monoatomic cation channel activity 15/1291 341/18639 0.0439882697947214 0.635087033852682 0.980734614398481 0.992328257485451 GO:0005254 chloride channel activity 2/1291 83/18639 0.0240963855421687 0.347895065933758 0.98161765061313 0.992328257485451 GO:0170055 lipid transmembrane transporter activity 1/1291 56/18639 0.0178571428571429 0.257815093504482 0.982150531767652 0.992328257485451 GO:0004601 peroxidase activity 1/1291 57/18639 0.0175438596491228 0.253292021688613 0.98339057177669 0.992723873148169 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 1/1291 59/18639 0.0169491525423729 0.244705851461881 0.985618365501536 0.994115075548963 GO:0008083 growth factor activity 5/1291 162/18639 0.0308641975308642 0.44560633445219 0.989374557347826 0.996783054143365 GO:0004536 DNA nuclease activity 1/1291 64/18639 0.015625 0.225588206816421 0.989967443516744 0.996783054143365 GO:0005253 monoatomic anion channel activity 2/1291 103/18639 0.0194174757281553 0.280342625946621 0.994751271004432 0.999999985009469 GO:0004497 monooxygenase activity 2/1291 106/18639 0.0188679245283019 0.272408400683981 0.995663765657987 0.999999985009469 GO:0009055 electron transfer activity 2/1291 116/18639 0.0172413793103448 0.248924917866396 0.997716394515228 0.999999985009469 GO:0005216 monoatomic ion channel activity 17/1291 448/18639 0.0379464285714286 0.547857073697023 0.998430276402159 0.999999985009469 GO:0003735 structural constituent of ribosome 3/1291 175/18639 0.0171428571428571 0.247502489764302 0.999669914787112 0.999999985009469 GO:0005179 hormone activity 1/1291 132/18639 0.00757575757575758 0.109376100274629 0.999925856524555 0.999999985009469 GO:0045182 translation regulator activity 5/1291 356/18639 0.0140449438202247 0.20277591623948 0.999999842504873 0.999999985009469 GO:0030371 translation repressor activity 3/1291 329/18639 0.00911854103343465 0.131650260512927 0.999999985009469 0.999999985009469