category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	17/253	142/9376	4.43667538829817	FCGR3B/FOSL2/JUND/GAB2/TYROBP/TNFRSF1A/FOSB/NCF4/FOSL1/FCGR3A/NCF1/LILRB2/IFNGR2/PPP3CA/IFNAR2/LCP2/JUNB	6.87170981098317
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	17/253	173/9376	3.6416641915511	MX2/RSAD2/BID/OAS1/OAS3/TNFRSF1A/OAS2/PYCARD/KPNA1/NUP98/TNFSF10/ACTB/IFNGR2/CASP9/ACTG1/IFNAR2/CREBBP	5.84000220601477
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	19/253	250/9376	2.81650592885376	HLA-C/VPS37B/IQSEC1/ARPC3/SMAP2/CXCR2/ACTR3/ASAP1/AP2B1/ARF4/CAPZA1/ARAP1/SH3KBP1/CHMP4B/CHMP5/GRK5/RAB8A/CHMP1B/ARPC2	4.84778837775087
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	13/253	133/9376	3.62233647359505	BRAF/HLA-C/PAK1/FCGR3B/ITGB2/BID/TYROBP/FCGR3A/TNFSF10/IFNGR2/PPP3CA/IFNAR2/LCP2	5.07206512053037
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	11/253	98/9376	4.15971606033718	PAK1/FCGR3B/ARPC3/PTPRC/ACTR3/GAB2/ASAP1/FCGR3A/NCF1/WAS/ARPC2	5.23613665866125
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	13/253	137/9376	3.51657482473097	MCL1/TUBA1A/BID/BCL2A1/TNFRSF1A/PMAIP1/TNFSF10/ACTB/BIRC2/CASP9/TUBA4A/ACTG1/CTSS	4.94122589912572
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	18/253	248/9376	2.68978707127375	PAK1/TUBA1A/MAP2K3/ARPC3/PTPRC/ACTR3/CYFIP2/TNFRSF1A/PYCARD/KPNA1/ELMO1/TNFSF10/ACTB/BIRC2/TUBA4A/ACTG1/FLNA/ARPC2	4.4910415081887
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	9/253	73/9376	4.56895338134171	ELL2/MX2/SERINC3/APOBEC3A/BST2/SUPT4H1/CHMP4B/ELL/CREBBP	5.09762467184632
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	13/253	155/9376	3.10819839347189	HLA-C/FCGR3B/TUBA1A/ITGB2/NCF4/FCGR3A/CORO1A/NCF1/ACTB/TUBA4A/TAP1/ACTG1/CTSS	4.40722656855413
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	15/253	200/9376	2.77944664031621	PAK1/TUBA1A/MYH9/GNA13/ARPC3/ACTR3/CYFIP2/TNFRSF1A/PYCARD/TNFSF10/ACTB/CASP9/TUBA4A/ACTG1/ARPC2	4.23594513350474
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	14/253	180/9376	2.88238910847606	HLA-C/B2M/PILRA/BID/OAS1/OAS3/TNFRSF1A/OAS2/BST2/IFNGR2/BIRC2/CASP9/TAP1/IFNAR2	4.24642280915291
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	14/253	181/9376	2.86646430677178	FCGR3B/CEBPB/ITGB2/BID/VDR/TNFRSF1A/ITGAX/FCGR3A/CORO1A/IFNGR2/CASP9/PPP3CA/CREBBP/CTSS	4.22240776106158
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	13/253	168/9376	2.86768304159609	FTH1/BID/TNFRSF1A/PYCARD/TNFSF10/IFNGR2/BIRC2/CHMP4B/CHMP5/GLUL/IFNAR2/STAT5B/CHMP1B	4.06773097329481
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	12/253	156/9376	2.85071450288842	BRAF/MX2/RSAD2/BID/OAS1/IFIT1/OAS3/TNFRSF1A/OAS2/YWHAZ/CASP9/IFNAR2	3.88162278310662
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	5/253	32/9376	5.79051383399209	BID/TNFRSF1A/PMAIP1/BIRC2/CASP9	4.52030494997926
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	13/253	187/9376	2.57631417640718	ANTXR2/OAS1/GBP1/GBP2/OAS3/OAS2/PYCARD/GBP5/CARD16/GABARAPL1/NAMPT/BIRC2/IFNAR2	3.62582233773042
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	14/253	214/9376	2.42443943703594	HLA-C/PAK1/B2M/BID/MAP2K3/GNAI3/AP1G1/APOBEC3A/TNFRSF1B/TNFRSF1A/BST2/CASP9/TAP1/PPP3CA	3.51020752866819
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	9/253	115/9376	2.90029214641691	BRAF/PDE4B/OXSR1/NR4A2/GNA13/JUND/GNAI3/VDR/MEF2C	3.41442370525739
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	10/253	138/9376	2.68545569112677	MAP2K3/ARPC3/ACTR3/PYCARD/ELMO1/ACTB/WAS/ACTG1/LCP2/ARPC2	3.32158190139557
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	9/253	119/9376	2.80280333477264	PTGS2/MAP3K8/CEBPB/MAP2K3/TNFRSF1B/TNFRSF1A/BCL3/BIRC2/JUNB	3.29582211042531
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	7/253	78/9376	3.32583358670315	PTGS2/FCGR3B/ITGB2/NCF4/FCGR3A/NCF1/IFNGR2	3.43485358574051
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	11/253	170/9376	2.39795396419437	TUBA1A/MYH9/ARPC3/ACTR3/MYL6/ACTB/WAS/TUBA4A/ACTG1/RAB8A/ARPC2	3.06308399965338
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	14/253	250/9376	2.07532015810277	BORCS5/LAPTM5/HGSNAT/AP1G1/LAMTOR4/AP2B1/SLC36A4/SLC11A1/GALC/LIPA/CTBS/GNS/IDS/CTSS	2.86975367490337
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	10/253	154/9376	2.40644730763308	PTGS2/RGS2/PIK3R5/GNAI3/MYL6/MEF2C/CAMK1D/ACTB/ACTG1/PPP3CA	2.93054455647557
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	13/253	232/9376	2.07659806460406	BRAF/PAK1/MYH9/GNA13/ITGB2/ARPC3/ACTR3/CYFIP2/ITGAX/ACTB/ACTG1/IQGAP2/ARPC2	2.76507260759233
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	6/253	70/9376	3.17651044607566	HLA-C/ITGB2/BID/ACTB/CASP9/ACTG1	3.0437243110595
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	7/253	94/9376	2.75973425279623	PTGS2/S100A9/CEBPB/JUND/S100A8/FOSB/FOSL1	2.85540222547645
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	3/253	19/9376	5.85146661119201	HGSNAT/GNS/IDS	3.52499571920415
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	9/253	142/9376	2.34882814674609	DUSP1/IL1R2/TNFRSF1A/NFE2L2/NCF1/MEF2C/ACTB/THBD/ACTG1	2.69701224645346
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	11/253	193/9376	2.11218742960126	FOXO3/BRAF/PAK1/PIK3R5/GNAI3/CXCR2/ELMO1/NCF1/WAS/GRK5/STAT5B	2.59980877873103
NA	NA	hsa04517	IgSF CAM signaling	15/253	299/9376	1.85916163231853	PAK1/TUBA1A/MYH9/ITGB2/ARPC3/ACTR3/MYL6/ITGAX/ICAM3/ACTB/TUBA4A/JAML/ACTG1/LCP2/ARPC2	2.51429575562423
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	11/253	195/9376	2.09052396878484	C5AR1/FCGR3B/PADI4/ITGB2/AQP9/NCF4/FPR1/FCGR3A/NCF1/ACTB/ACTG1	2.5626222275083
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	11/253	196/9376	2.07985803016859	PTGS2/HLA-C/PIK3R5/BID/CLEC2B/TNFRSF1A/MAPKAPK2/CASP9/PPP3CA/IFNAR2/CREBBP	2.54419513963136
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	6/253	78/9376	2.85071450288842	ARPC3/ACTR3/ELMO1/ACTB/ACTG1/ARPC2	2.73318494615049
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	11/253	205/9376	1.98854718981972	HLA-C/B2M/ISG15/BID/MAP2K3/OAS1/OAS3/OAS2/CASP9/TAP1/IFNAR2	2.38310430402086
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	12/253	238/9376	1.8685355565151	C5AR1/MX2/ISG15/OAS1/OAS3/TNFRSF1A/OAS2/CFD/RPS9/IFNAR2/FAU/RPL30	2.26009953282968
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	11/253	212/9376	1.92288761279737	BRAF/SIPA1L1/RAPGEF1/ITGB2/MAP2K3/GNAI3/FPR1/RASSF5/ACTB/ACTG1/LCP2	2.26334765895325
Human Diseases	Infectious disease: viral	hsa05162	Measles	8/253	136/9376	2.17995814926761	MX2/BID/OAS1/OAS3/OAS2/CASP9/IFNAR2/STAT5B	2.30821965044248
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	6/253	88/9376	2.52676967301473	PLAUR/C5AR1/ITGB2/ITGAX/CFD/THBD	2.39624278818921
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	7/253	112/9376	2.31620553359684	PIK3R5/MAP2K3/GNAI3/TNFRSF1A/IFNGR2/BIRC2/CASP9	2.33351454287627
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	11/253	216/9376	1.88727858293076	BID/MAP2K3/TNFRSF1A/PYCARD/NCF4/NFE2L2/NCF1/TNFSF10/ABCA1/CASP9/PPP3CA	2.19692989580483
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	4/253	46/9376	3.22254682935212	PSMB9/POMP/PSME1/PSMB8	2.51632119508238
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	9/253	166/9376	2.00923853516834	RGS2/ATP2B1/PIK3R5/GNA13/GNAI3/PDE3B/MEF2C/PPP3CA/PDE2A	2.18471663163052
Human Diseases	Substance dependence	hsa05032	Morphine addiction	6/253	91/9376	2.44346957390436	PDE4B/PDE7A/GNAI3/PDE3B/GRK5/PDE2A	2.30416957381688
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	7/253	116/9376	2.23633637726591	ITGB2/GNAI3/NCF4/NCF1/RASSF5/ACTB/ACTG1	2.2311933686898
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	11/253	227/9376	1.79582455468301	PTGS2/HLA-C/B2M/GNA13/BID/GNAI3/CXCR2/TNFRSF1A/CASP9/TAP1/PPP3CA	2.02125222535923
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	10/253	201/9376	1.84374569838554	NR4A3/CEBPB/REL/IL1R2/BCL2A1/JMJD1C/DDX5/MEF2C/BIRC2/RARA	2.01364832561344
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	5/253	73/9376	2.53830743407873	FOXO3/BRAF/RASSF5/CASP9/STAT5B	2.19720267847722
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	6/253	99/9376	2.24601748712421	C5AR1/FCGR3B/ITGB2/FPR1/FCGR3A/CFD	2.07546310669014
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	5/253	75/9376	2.47061923583663	BID/PMAIP1/BIRC2/CASP9/ERCC1	2.12933068770495
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	5/253	75/9376	2.47061923583663	BID/SESN2/PMAIP1/COP1/CASP9	2.12933068770495
Organismal Systems	Immune system	hsa04611	Platelet activation	7/253	126/9376	2.05884936319719	PIK3R5/GNA13/GNAI3/ACTB/ACTG1/LCP2/P2RX1	1.99262533272574
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	13/253	300/9376	1.60590250329381	BRAF/DUSP1/PAK1/MAP3K8/JUND/MAP2K3/MAP4K4/TNFRSF1A/DUSP2/MEF2C/MAPKAPK2/PPP3CA/FLNA	1.77620542387691
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	6/253	105/9376	2.11767363071711	PTGS2/PAK1/PYCARD/BCL3/MAPKAPK2/PPP3CA	1.91788880929079
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	5/253	82/9376	2.25971271570423	HLA-C/B2M/PSME1/TAP1/CTSS	1.90789366812194
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	15/253	368/9376	1.51056882625881	C9orf72/TUBA1A/BID/MAP2K3/ATG2A/TNFRSF1B/TNFRSF1A/NUP98/ACTB/CASP9/TUBA4A/ACTG1/PPP3CA/RAB8A/NDUFB1	1.66395308237098
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	4/253	60/9376	2.47061923583663	PTGS2/MAPKAPK2/CASP9/PPP3CA	1.90299737360292
Cellular Processes	Cell motility	hsa04814	Motor proteins	9/253	194/9376	1.71924534452549	TPM4/TUBA1A/MYH9/MYL6/CAPZA1/ACTB/TUBA4A/ACTG1/KIF1B	1.68572350165829
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	4/253	62/9376	2.39092184113222	NUMB/TLE4/TLE3/CREBBP	1.82981640145563
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	8/253	169/9376	1.75428584793133	C9orf72/TP53INP2/ATG2A/ATG16L2/DDIT4/MTMR3/GABARAPL1/RAB8A	1.64777269349949
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	6/253	120/9376	1.85296442687747	FOXO3/BRAF/RAPGEF1/ARHGDIB/SH2B2/MAPKAPK2	1.56598259415158
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/253	21/9376	3.52945605119518	CHST15/CHSY1	1.93237740557592
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/253	21/9376	3.52945605119518	PPCDC/VNN2	1.93237740557592
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	4/253	68/9376	2.17995814926761	BRAF/BCL2A1/RARA/STAT5B	1.62618493872889
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	4/253	70/9376	2.11767363071711	BRAF/PAK1/RAPGEF1/CREBBP	1.56300210172551
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	7/253	157/9376	1.65232496664233	PTGS2/CEBPB/ELMO1/DUSP2/MAPKAPK2/ABCA1/LIPA	1.37261575927529
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	7/253	160/9376	1.62134387351779	HLA-C/ITGB2/PTPRC/VSIR/SELL/ICAM3/JAML	1.32007267120625
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	6/253	133/9376	1.67184760319772	FOXO3/BRAF/TNFSF10/GABARAPL1/CDKN2D/CREBBP	1.29947275218248
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	7/253	163/9376	1.59150318872912	BRAF/BID/MAP2K3/YWHAZ/CASP9/STAT5B/CREBBP	1.26860791936583
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	9/253	224/9376	1.48898927159797	HLA-C/B2M/ITGB2/IL1R2/TNFRSF1A/FOSL1/PPP3CA/STAT5B/CREBBP	1.23350920752026
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	5/253	105/9376	1.76472802559759	PTGS2/BCL2A1/TNFRSF1A/TNFSF13B/BIRC2	1.31224651108896
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	4/253	78/9376	1.90047633525894	INPP5A/INPP4A/ITPK1/MTMR3	1.32984766697043
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	3/253	52/9376	2.13803587716631	ABCA1/LIPA/MYLIP	1.37035646926502
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	3/253	53/9376	2.09769557759714	ATP2B1/VDR/AP2B1	1.33450150703642
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/253	28/9376	2.64709203839639	B3GNT5/B4GALT1	1.45349851733868
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/253	29/9376	2.55581300258961	PAK1/RASSF2	1.39732469911374
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	8/253	204/9376	1.45330543284507	PLAUR/BRAF/PAK1/PDCD4/DDX5/ACTB/ACTG1/FLNA	1.0900616132214
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	3/253	56/9376	1.98531902879729	ITGB2/PYCARD/CASP9	1.23151580198689
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	4/253	85/9376	1.74396651941409	CDA/CMPK2/AMPD2/TYMP	1.14738372585286
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/253	31/9376	2.39092184113222	TALDO1/TKT	1.29172772797802
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	3/253	59/9376	1.88437060360421	CDA/CMPK2/TYMP	1.13474771703401
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	3/253	59/9376	1.88437060360421	PTGS2/GNAI3/PDE3B	1.13474771703401
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	3/253	59/9376	1.88437060360421	FOXO3/BRAF/CASP9	1.13474771703401
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	2/253	32/9376	2.31620553359684	ATG2A/GABARAPL1	1.24196497388044
Organismal Systems	Nervous system	hsa04730	Long-term depression	3/253	60/9376	1.85296442687747	BRAF/GNA13/GNAI3	1.10374529624667
Organismal Systems	Digestive system	hsa04978	Mineral absorption	3/253	61/9376	1.82258796086309	ATP2B1/FTH1/VDR	1.07332908565607
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	5/253	122/9376	1.51882330071924	PAK1/MAP3K8/PTPRC/PPP3CA/LCP2	0.96053169816489
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	5/253	122/9376	1.51882330071924	ACTB/CASP9/NCOA2/ACTG1/CREBBP	0.96053169816489
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	5/253	122/9376	1.51882330071924	MAP2K3/GNAI3/STAT5B/JUNB/CREBBP	0.96053169816489
NA	NA	hsa04518	Integrin signaling	6/253	154/9376	1.44386838457985	ITGB2/ITGAX/ICAM3/ACTB/ACTG1/FLNA	0.92486655643798
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	3/253	63/9376	1.76472802559759	CCNH/RPA2/ERCC1	1.01416715434973
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	4/253	93/9376	1.59394789408815	ACTB/WAS/ACTG1/CREBBP	0.958567515404459
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	9/253	253/9376	1.31831461200769	FOXO3/ARPC3/ACTR3/TNFRSF1A/PYCARD/ELMO1/ACTB/ACTG1/ARPC2	0.854722348360029
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	5/253	125/9376	1.48237154150198	GNA13/BID/GNAI3/GAB2/TNFRSF1A	0.904106111949651
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	6/253	157/9376	1.41627854283628	FOXO3/HLA-C/MAP2K3/MAPKAPK2/RASSF5/PPP3CA	0.875929203026398
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	6/253	157/9376	1.41627854283628	ITGB2/BMP6/YWHAZ/ACTB/BIRC2/ACTG1	0.875929203026398
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	6/253	158/9376	1.40731475459048	CCNH/PRKDC/TFDP1/YWHAZ/CDKN2D/CREBBP	0.859839505951582
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	6/253	158/9376	1.40731475459048	BRAF/SESN2/LAMTOR4/TNFRSF1A/SLC7A5/DDIT4	0.859839505951582
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	3/253	65/9376	1.71042870173305	GPAT3/ABHD16A/DGAT2	0.957097265079316
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	5/253	128/9376	1.44762845849802	PDE4B/PDE7A/PDE3B/AMPD2/PDE2A	0.849133207019893
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	3/253	67/9376	1.65937112854699	BRAF/PPP3CA/CREBBP	0.901971623467019
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	4/253	98/9376	1.51262402194079	INPP5A/INPP4A/ITPK1/MTMR3	0.849497037752221
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	4/253	98/9376	1.51262402194079	NR4A2/ATP2B1/CAMK1D/PDE2A	0.849497037752221
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	2/253	38/9376	1.95048887039734	PTPRC/TAP1	0.977662507730579
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	4/253	100/9376	1.48237154150198	CXCR2/TNFRSF1B/TNFRSF1A/TNFSF10	0.807566637990982
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	10/253	298/9376	1.24360028649495	OSM/BMP6/CXCR2/IL1R2/TNFRSF1B/TNFRSF1A/TNFSF13B/TNFSF10/IFNGR2/IFNAR2	0.711652368204964
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	3/253	69/9376	1.61127341467606	MAP2K3/GAB2/LCP2	0.848657117218205
Organismal Systems	Endocrine system	hsa04924	Renin secretion	3/253	69/9376	1.61127341467606	GNAI3/PDE3B/PPP3CA	0.848657117218205
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/253	13/9376	2.85071450288842	PRKDC	1.11193820937595
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	6/253	168/9376	1.32354601919819	MCL1/OSM/IFNGR2/IFNAR2/STAT5B/CREBBP	0.70466890487693
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	2/253	41/9376	1.80777017256339	BRAF/TYMP	0.863176565468981
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	7/253	203/9376	1.27790650129481	BRAF/PAK1/RAPGEF1/ACTB/BIRC2/ACTG1/FLNA	0.666604268483679
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	2/253	42/9376	1.76472802559759	FTH1/SAT1	0.827131984011473
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	4/253	105/9376	1.41178242047807	FOXO3/RABGEF1/ARIH1/GABARAPL1	0.706604212887137
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	15/253	480/9376	1.15810276679842	BRAF/PTGS2/C9orf72/TUBA1A/BID/MAP2K3/ATG2A/CSNK1A1/TNFRSF1B/TNFRSF1A/CASP9/TUBA4A/PPP3CA/RAB8A/NDUFB1	0.592160948076645
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	5/253	138/9376	1.34272784556338	BRAF/RAPGEF1/INPP5A/PDE3B/SH2B2	0.675424821263966
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	7/253	205/9376	1.26543912079437	HLA-C/REL/YWHAZ/PMAIP1/MAPKAPK2/STAT5B/CREBBP	0.639897738555034
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/253	14/9376	2.64709203839639	B4GALT1	1.02700989686302
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	4/253	106/9376	1.39846371839809	BRAF/IL1R2/CASP9/CREBBP	0.68703507624673
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/253	43/9376	1.72368783895579	ABCA1/DGAT2	0.792048782845739
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	5/253	140/9376	1.32354601919819	PIK3R5/GNA13/GNAI3/PDE3B/MEF2C	0.64229594152985
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	3/253	75/9376	1.48237154150198	TALDO1/TKT/GLUL	0.69843267459464
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	2/253	44/9376	1.68451311534315	HLA-C/PTPRN2	0.757875396083731
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	3/253	76/9376	1.462866652798	GNAI3/ACTB/ACTG1	0.674680683776061
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	4/253	109/9376	1.35997389128622	IFNGR2/RARA/PPP3CA/STAT5B	0.629494197964487
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/253	45/9376	1.64707949055775	ABCA1/TAP1	0.724564177085149
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	3/253	77/9376	1.44386838457985	BRAF/RALBP1/CASP9	0.651266160052192
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	3/253	77/9376	1.44386838457985	BRAF/GAB2/STAT5B	0.651266160052192
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	6/253	178/9376	1.24918950126571	CSNK1A1/FOSL1/TLE4/TLE3/PPP3CA/CREBBP	0.55894631947368
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	3/253	78/9376	1.42535725144421	BTG1/BTG2/CNOT2	0.628179027380406
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	3/253	78/9376	1.42535725144421	ITGB2/GNAI3/PYCARD	0.628179027380406
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/253	17/9376	2.17995814926761	GLUL	0.810874050575381
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/253	17/9376	2.17995814926761	MYH9	0.810874050575381
NA	NA	hsa03272	Virion - Hepatitis viruses	2/253	48/9376	1.54413702239789	CHMP4B/CHMP1B	0.629378187064793
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	4/253	115/9376	1.28901873174085	BRAF/DUSP1/PTGS2/GNAI3	0.519305629284476
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	2/253	49/9376	1.51262402194079	GNAI3/FOSB	0.599105169045043
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	3/253	83/9376	1.33949235677889	JARID2/TFDP1/CREBBP	0.517330567278666
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	2/253	51/9376	1.45330543284507	ACTB/ACTG1	0.540541015566639
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	5/253	154/9376	1.20322365381654	ATP2B1/TPM4/PIK3R5/GNAI3/CREM	0.423447056428584
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/253	19/9376	1.95048887039734	OGDH	0.690609555381148
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	7/253	226/9376	1.14785406974711	BRAF/PDE4B/PAK1/ATP2B1/GNAI3/PDE3B/CREBBP	0.374674397032146
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	10/253	333/9376	1.11289154767416	PTGS2/MX2/HLA-C/ISG15/OASL/CSNK1A1/TNFRSF1A/HES4/IFNAR2/CREBBP	0.349304627967165
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	3/253	86/9376	1.29276587921684	BRAF/PAK1/STAT5B	0.454191382422064
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	2/253	52/9376	1.42535725144421	PTGS2/BMP6	0.512190408897076
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	3/253	87/9376	1.27790650129481	BRAF/PMAIP1/CASP9	0.433661545198549
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/253	20/9376	1.85296442687747	LIPA	0.635883962384914
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	2/253	54/9376	1.37256624213146	RPA2/ERCC1	0.457217551211774
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/253	54/9376	1.37256624213146	HLA-C/TG	0.457217551211774
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	3/253	89/9376	1.24918950126571	TUBA1A/GNAI3/TUBA4A	0.393336349452526
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	3/253	89/9376	1.24918950126571	GNAI3/GABARAPL1/GLUL	0.393336349452526
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	3/253	90/9376	1.23530961791831	MAP2K3/IFNGR2/PPP3CA	0.373528423662651
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	7/253	233/9376	1.11336918353153	TPM4/MYH9/FMNL1/CAPZA1/AMPD2/ACTB/ACTG1	0.291813702497532
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	3/253	91/9376	1.22173478695218	IFITM1/LILRB2/PPP3CA	0.35394895658939
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	3/253	93/9376	1.19546092056611	IFNGR2/PPP3CA/STAT5B	0.315452737269775
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	3/253	93/9376	1.19546092056611	PTGS2/BIRC2/CASP9	0.315452737269775
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/253	23/9376	1.61127341467606	GLUL	0.488766036801596
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/253	23/9376	1.61127341467606	B4GALT1	0.488766036801596
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/253	23/9376	1.61127341467606	RPA2	0.488766036801596
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/253	23/9376	1.61127341467606	ANPEP	0.488766036801596
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	11/253	388/9376	1.05064993276558	BRAF/PTGS2/TUBA1A/BID/ATG2A/CSNK1A1/TNFRSF1A/CASP9/TUBA4A/PPP3CA/NDUFB1	0.169683754682382
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	5/253	170/9376	1.08997907463381	BRAF/CSNK1A1/NFE2L2/ACTB/ACTG1	0.197154892702967
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	4/253	134/9376	1.10624741903133	BRAF/MYH9/GNA13/MYL6	0.206283678567834
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	3/253	99/9376	1.1230087435621	TPM4/ACTB/ACTG1	0.204892878070823
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	5/253	174/9376	1.06492208441234	SEC31A/NFE2L2/SEC23B/CKAP4/DNAJC5	0.143947135183341
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	3/253	100/9376	1.11177865612648	ANPEP/IL1R2/CD37	0.187135238629834
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	3/253	103/9376	1.07939675352086	GNAI3/TNFRSF1A/IFNGR2	0.134923714385521
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	3/253	105/9376	1.05883681535855	TPM4/ACTB/ACTG1	0.100961914685309
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	4/253	144/9376	1.02942468159859	FOXO3/C5AR1/MAP2K3/TNFRSF1A	0.0592546151218537
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	3/253	107/9376	1.0390454730154	PDE3B/PPP3CA/CREBBP	0.0676430524954059
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	2/253	69/9376	1.07418227645071	FOSB/PPP3CA	0.102990438271725
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/253	30/9376	1.23530961791831	OGDH	0.214963378452459
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	2/253	70/9376	1.05883681535855	TNFRSF1B/TNFRSF1A	0.082279892391532
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/253	70/9376	1.05883681535855	PTGS2/SULT1A1	0.082279892391532
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	3/253	109/9376	1.01998041846466	MAP3K8/MAP2K3/IFNAR2	0.0349401937220138
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/253	31/9376	1.19546092056611	GLUL	0.181521551653708
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	3/253	110/9376	1.01070786920589	PFKFB3/IFNGR2/CREBBP	0.0188117983063994
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	3/253	110/9376	1.01070786920589	TFDP1/BMP6/CREBBP	0.0188117983063994
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	3/253	110/9376	1.01070786920589	BRAF/GNAI3/PDE3B	0.0188117983063994
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	4/253	149/9376	0.994880229195957	PIK3R5/GNA13/CXCR2/GAB2	-0.0104903615084092
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	2/253	71/9376	1.04392362077604	FOXO3/STAT5B	0.0618651656738287
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	2/253	71/9376	1.04392362077604	PAK1/CXCR2	0.0618651656738287
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	2/253	71/9376	1.04392362077604	SLC16A3/SLC7A5	0.0618651656738287
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	2/253	72/9376	1.02942468159859	ISG15/ZNFX1	0.0417369040369422
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/253	32/9376	1.15810276679842	B4GALT1	0.1491849818475
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	7/253	268/9376	0.96796649165241	DUSP1/TUBA1A/GNAI3/NFE2L2/CASP9/TUBA4A/NDUFB1	-0.0886007612066696
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	8/253	308/9376	0.962578923053231	TUBA1A/ATG2A/AP2B1/RCOR1/CASP9/TUBA4A/NDUFB1/CREBBP	-0.11120208900909
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/253	33/9376	1.1230087435621	OGDH	0.117876393374446
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/253	33/9376	1.1230087435621	STX11	0.117876393374446
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/253	34/9376	1.08997907463381	NFIL3	0.0875262074835216
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	3/253	116/9376	0.958429875971105	TALDO1/TKT/OGDH	-0.0750208331441284
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	3/253	116/9376	0.958429875971105	GNAI3/PPP3CA/GLUL	-0.0750208331441284
Human Diseases	Cancer: specific types	hsa05214	Glioma	2/253	76/9376	0.975244435198669	BRAF/CAMK1D	-0.0360840455592589
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	7/253	275/9376	0.943327344592167	TUBA1A/NCF4/NCF1/CASP9/TUBA4A/PPP3CA/NDUFB1	-0.158844584563035
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/253	35/9376	1.05883681535855	PFKFB3	0.0580715683497941
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	6/253	238/9376	0.934267778257548	PAK1/RALGAPA1/REL/GAB2/RALBP1/RASSF5	-0.17104810797621
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/253	36/9376	1.02942468159859	RPA2	0.0294555167207152
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/253	37/9376	1.00160239290674	GLUL	0.00162628534895355
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	1/253	37/9376	1.00160239290674	BRAF	0.00162628534895355
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	2/253	80/9376	0.926482213438735	FOXO3/BRAF	-0.109968023752645
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	3/253	122/9376	0.911293980431543	FOXO3/PFKFB3/RAB8A	-0.164227287971492
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/253	38/9376	0.975244435198669	NAMPT	-0.0254633045348957
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	2/253	82/9376	0.903885086281693	CDA/TYMP	-0.1455705201743
NA	NA	hsa04519	Cadherin signaling	10/253	404/9376	0.91730912221657	MAP2K3/ARPC3/ACTR3/CSNK1A1/CYFIP2/YWHAZ/ACTB/ACTG1/ARPC2/CREBBP	-0.282931116607055
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/253	39/9376	0.950238167629472	HLA-C	-0.051856362472295
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/253	41/9376	0.903885086281693	RPA2	-0.102707606608494
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	2/253	86/9376	0.861843919477893	ACTB/ACTG1	-0.214332699460082
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	1/253	44/9376	0.842256557671577	B4GALT1	-0.174649500724807
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/253	44/9376	0.842256557671577	CCNH	-0.174649500724807
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	1/253	44/9376	0.842256557671577	ARHGDIB	-0.174649500724807
NA	NA	hsa04382	Cornified envelope formation	5/253	217/9376	0.853900657547221	S100A6/S100A9/S100A4/S100A8/S100A11	-0.362602805606379
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	2/253	90/9376	0.823539745278876	FOXO3/SESN2	-0.280111460671245
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/253	45/9376	0.823539745278876	HLA-C	-0.197590529627265
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/253	46/9376	0.80563670733803	FTH1	-0.220054068788229
Organismal Systems	Digestive system	hsa04970	Salivary secretion	2/253	93/9376	0.796973947044073	ATP2B1/LYZ	-0.327662040864909
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	3/253	139/9376	0.799840759803225	GNAI3/NCOA2/RARA	-0.395908324478606
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	2/253	95/9376	0.780195548158935	ITGB2/TNFSF13B	-0.358573311385022
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	5/253	227/9376	0.816283888492278	FOXO3/BRAF/NFE2L2/NCF1/NDUFB1	-0.466606109392085
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	1/253	49/9376	0.756312010970396	B4GALT1	-0.284798853766337
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	3/253	142/9376	0.78294271558203	UBE2R2/BIRC2/COP1	-0.434010926943829
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/253	50/9376	0.741185770750988	SAT1	-0.305564225839888
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/253	50/9376	0.741185770750988	TNFSF13B	-0.305564225839888
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	1/253	50/9376	0.741185770750988	ITGB2	-0.305564225839888
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	2/253	99/9376	0.748672495708069	WAS/SLC22A4	-0.418630531468948
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/253	51/9376	0.726652716422537	PAFAH1B1	-0.325951130433157
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	2/253	101/9376	0.733847297773256	GNAI3/CREBBP	-0.447828438315463
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	2/253	101/9376	0.733847297773256	THBD/STAT5B	-0.447828438315463
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	2/253	102/9376	0.726652716422537	ATP2B1/RAB8A	-0.4622302499937
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	8/253	362/9376	0.818989801934794	FOXO3/MCL1/PIK3R5/OSM/YWHAZ/DDIT4/CASP9/IFNAR2	-0.58489190856648
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	3/253	149/9376	0.746160171896968	PTGS2/GNAI3/NDUFB1	-0.520115384839202
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	2/253	103/9376	0.719597835680571	ITGB2/IL1R2	-0.476504389084098
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	1/253	55/9376	0.673805246137262	GALC	-0.404021172058986
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	1/253	56/9376	0.661773009599096	B4GALT1	-0.422738089048794
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	1/253	56/9376	0.661773009599096	CSNK1A1	-0.422738089048794
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	2/253	108/9376	0.68628312106573	KPNA1/NUP98	-0.546051761274246
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	3/253	157/9376	0.708139271418141	BID/TNFRSF1A/NDUFB1	-0.614130465720292
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	1/253	59/9376	0.628123534534736	ANPEP	-0.47715965284871
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	1/253	62/9376	0.597730460283055	FOXO3	-0.529202561792327
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	5/253	254/9376	0.729513553888768	ATP2B1/CAMK1D/PPP3CA/CYSLTR1/P2RX1	-0.727770409373789
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	2/253	115/9376	0.644509365870425	PIK3R5/GNAI3	-0.638741601104689
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/253	63/9376	0.588242675199197	PTGS2	-0.546064405119148
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	2/253	117/9376	0.633492111752981	ACTB/ACTG1	-0.664310744072052
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/253	66/9376	0.561504371781052	HSD17B11	-0.595304898884951
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/253	66/9376	0.561504371781052	IFNGR2	-0.595304898884951
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	4/253	217/9376	0.683120526037777	GNAI3/VDR/KPNA1/STAT5B	-0.786460666891183
Genetic Information Processing	Translation	hsa03010	Ribosome	4/253	222/9376	0.667734928604494	RPS9/MRPL33/FAU/RPL30	-0.834320248880214
Human Diseases	Cancer: specific types	hsa05218	Melanoma	1/253	73/9376	0.507661486815745	BRAF	-0.703219314891885
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	1/253	75/9376	0.494123847167325	TG	-0.732465338515673
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	3/253	184/9376	0.604227530503523	PAK1/GNAI3/PPP3CA	-0.902872750422627
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	2/253	133/9376	0.557282534399239	GNAI3/PPP3CA	-0.856294315444882
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	4/253	235/9376	0.630796400639139	MAP2K3/ACTB/ACTG1/NDUFB1	-0.954509080537958
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	1/253	79/9376	0.469104918196828	AP2B1	-0.789092459988333
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	2/253	138/9376	0.537091138225354	YWHAZ/PPP3CA	-0.912269426814994
Human Diseases	Substance dependence	hsa05034	Alcoholism	3/253	191/9376	0.582083066034807	BRAF/GNAI3/FOSB	-0.971726695073435
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	1/253	83/9376	0.446497452259631	PYCARD	-0.843446932736701
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	2/253	143/9376	0.518311727797894	FCGR3B/FCGR3A	-0.966584295872424
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	1/253	87/9376	0.425968833764936	TPM4	-0.895751777600731
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	2/253	148/9376	0.50080119645337	BRAF/CSNK1A1	-1.01936017409468
Organismal Systems	Digestive system	hsa04976	Bile secretion	1/253	90/9376	0.411769872639438	AQP9	-0.933751345005141
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	2/253	150/9376	0.494123847167325	BRAF/CSNK1A1	-1.04006425999302
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	3/253	205/9376	0.542331051769016	NCF4/NCF1/NDUFB1	-1.10330882691079
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	1/253	93/9376	0.398486973522037	MAP2K3	-0.970776818999592
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	2/253	154/9376	0.481289461526616	PPCDC/CMPK2	-1.08081144359961
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	2/253	155/9376	0.478184368226444	BRAF/GNAI3	-1.09086494106085
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	1/253	97/9376	0.382054521005664	GNAI3	-1.01873798646581
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	1/253	99/9376	0.374336247854034	BRAF	-1.04215394100872
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	1/253	99/9376	0.374336247854034	MAP2K3	-1.04215394100872
NA	NA	hsa04081	Hormone signaling	3/253	219/9376	0.507661486815745	GNA13/GNAI3/STAT5B	-1.22768322434308
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	5/253	323/9376	0.573673197175687	PTGS2/MCL1/PDCD4/DDIT4/CREBBP	-1.29844841204435
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	1/253	103/9376	0.359798917840285	ETF1	-1.08793249255372
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	1/253	103/9376	0.359798917840285	SLC36A4	-1.08793249255372
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	1/253	104/9376	0.356339312861052	GPAT3	-1.09916781713843
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	1/253	109/9376	0.339993472821554	TNFRSF1A	-1.15416781476293
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	1/253	130/9376	0.285071450288842	GNAI3	-1.36689272897542
NA	NA	hsa04082	Neuroactive ligand signaling	2/253	199/9376	0.372455161181401	GNAI3/P2RX1	-1.4900402355515
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	1/253	138/9376	0.268545569112677	NDUFB1	-1.44150084284131
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	1/253	144/9376	0.257356170399649	JARID2	-1.49551573389634
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	1/253	144/9376	0.257356170399649	ATG2A	-1.49551573389634
Genetic Information Processing	Transcription	hsa03040	Spliceosome	2/253	243/9376	0.305014720473658	BCAS2/DDX5	-1.82788586822166
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	4/253	370/9376	0.400640957162696	C5AR1/FPR1/CYSLTR1/P2RX1	-1.95884022721209
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/253	449/9376	0.165074781904452	RGS2/PDE2A	-3.01922197064942