category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	35/268	250/9376	4.89791044776119	PSAP/CTSD/HEXB/LGMN/LAPTM5/ASAH1/CD63/LAMP1/CD68/GNS/CLN8/LIPA/ATP6V0C/MITF/TPP1/CTSB/CTSA/ATP6V0E1/NPC2/ACP5/HEXA/AP1S2/ATP6V0A1/SLC17A5/ATP6V0B/CTSW/SLC29A1/CTSS/CTSK/RRAGD/GAA/ATP6V0D2/CTSH/ATP6AP1/ATP6V1B2	10.7152708601111
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	21/268	95/9376	7.73354281225452	HLA-DRB5/HLA-DQA2/TNF/TNFSF13B/CXCL3/CCL3/CXCL2/ITGB2/HLA-DMB/JUN/ATP6V0C/CCL5/ATP6V0E1/ACP5/FOS/ATP6V0A1/ATP6V0B/CTSK/ATP6V0D2/ATP6AP1/ATP6V1B2	11.3148699403214
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	24/268	155/9376	5.4170438131921	HLA-DRB5/HLA-C/MARCO/HLA-DQA2/HLA-A/ITGB2/HLA-DMB/LAMP1/CD14/ATP6V0C/HLA-E/HLA-F/COLEC12/ATP6V0E1/ATP6V0A1/NCF1/ATP6V0B/TAP1/FCGR3A/CTSS/FCGR2A/ATP6V0D2/ATP6AP1/ATP6V1B2	9.51152315322119
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	16/268	82/9376	6.82635602475428	HLA-DRB5/HLA-C/B2M/HLA-DQA2/HLA-A/TNF/LGMN/HLA-DMB/HLA-E/HLA-F/CTSB/IFI30/KLRD1/TAP1/CTSS/KLRC1	9.08958667811519
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	19/268	142/9376	4.68110153458062	NFKBIA/TNF/JUN/MITF/FOSL1/JUNB/SQSTM1/ACP5/FOSB/FOS/NCF1/LILRB4/FCGR3A/CTSK/PPARG/JUND/GAB2/FCGR2A/SIRPA	7.581734253249
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	11/268	45/9376	8.55190713101161	HLA-DRB5/HLA-C/HLA-DQA2/HLA-A/TNF/HLA-DMB/HLA-E/HLA-F/KLRD1/KLRC1/FAS	8.71044468283769
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	16/268	109/9376	5.135423798439	NFKBIA/CXCL9/TNF/MAP3K8/CCL3/CCL4/CXCL11/CXCL10/CD14/JUN/CCL5/TICAM1/FOS/CTSK/LY96/MAP2K3	7.44912418322049
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	13/268	71/9376	6.40571788942611	NFKBIA/CXCL3/CXCL2/JUN/ATP6V0C/CCL5/ATP6V0E1/ATP6V0A1/ADAM17/ATP6V0B/ATP6V0D2/ATP6AP1/ATP6V1B2	7.84270513706876
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	22/268	205/9376	3.75449581361485	HLA-DRB5/HLA-C/B2M/HLA-DQA2/NFKBIA/GADD45B/HLA-A/VIM/TNF/ISG15/CDKN1A/HLA-DMB/CXCL10/JUN/HLA-E/HLA-F/DDB2/BAX/MDM2/TAP1/FAS/MAP2K3	6.83993893844892
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	15/268	100/9376	5.24776119402985	CXCL9/TNF/CXCL3/CCL3/CXCL2/CXCR4/CCL4/CXCL11/CXCL10/XCL1/CCL18/XCL2/CCL5/TNFRSF14/IL10RA	7.3252296954642
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	20/268	181/9376	3.8657541024161	HLA-DRB5/HLA-DQA2/CTSD/TNF/ITGB2/HLA-DMB/LAMP1/CD14/ATP6V0C/CLEC4E/BAX/RIPK2/ATP6V0A1/ATP6V0B/FCGR3A/CTSS/IL10RA/FCGR2A/ATP6V0D2/ATP6AP1	6.67796083511571
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	19/268	180/9376	3.69286898839138	HLA-DRB5/HLA-C/B2M/HLA-DQA2/NFKBIA/HLA-A/TNF/HLA-DMB/HLA-E/PILRA/CCL5/TICAM1/HLA-F/BAX/TNFRSF14/TAP1/FAS/RHEB/SRSF7	6.25739427394701
Human Diseases	Immune disease	hsa05330	Allograft rejection	9/268	39/9376	8.07347876004592	HLA-DRB5/HLA-C/HLA-DQA2/HLA-A/TNF/HLA-DMB/HLA-E/HLA-F/FAS	7.59282170962069
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	15/268	119/9376	4.40988335632761	NFKBIA/TNF/MAP3K8/CXCL3/CXCL2/CXCL10/IRF1/JUN/CCL5/JUNB/FOS/ADAM17/FAS/MAP2K3/JAG1	6.42124730089601
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	12/268	78/9376	5.38231917336395	HLA-DRB5/HLA-DQA2/NFKBIA/TNF/ITGB2/HLA-DMB/JUN/FOS/NCF1/EEF1A1/FCGR3A/FCGR2A	6.66650270407828
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	19/268	196/9376	3.39141029546147	HLA-C/UBC/NFKBIA/HLA-A/CXCL3/CDKN1A/CXCL2/ZFP36/CLEC2B/RCAN1/MAP1LC3B/JUN/HLA-E/MICA/TICAM1/HLA-F/BAX/FOS/FAS	5.80366470428027
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	9/268	44/9376	7.15603799185889	HLA-DRB5/HLA-C/HLA-DQA2/HLA-A/TNF/HLA-DMB/HLA-E/HLA-F/FAS	7.02072219794255
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	20/268	224/9376	3.12366737739872	HLA-DRB5/HLA-C/B2M/HLA-DQA2/NFKBIA/HLA-A/TNF/CDKN1A/ITGB2/ZFP36/HLA-DMB/EGR1/JUN/HLA-E/FOSL1/HLA-F/BAX/FOS/EGR2/TSPO	5.51815662813599
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	25/268	333/9376	2.62650710411904	HLA-C/FN1/HLA-A/TNF/ISG15/CDKN1A/GNAS/IRF1/ATP6V0C/HLA-E/TICAM1/HLA-F/BAX/ATP6V0E1/MDM2/ATP6V0A1/ATP6V0B/FAS/RHEB/BCAP31/JAG1/ATP6V0D2/ATP6AP1/OASL/ATP6V1B2	5.18398027133264
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	19/268	227/9376	2.92826615819581	HLA-C/B2M/NFKBIA/HLA-A/TNF/CCL3/CDKN1A/CXCR4/GNAS/CCL4/HLA-E/CCL5/HLA-F/BAX/MDM2/TAP1/IL10RA/FAS/RHEB	5.04469156416016
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	14/268	137/9376	3.57511711515416	NFKBIA/GADD45B/LMNA/CTSD/TNF/JUN/CTSB/BAX/FOS/CTSW/CTSS/CTSK/FAS/CTSH	5.20818388705017
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	18/268	216/9376	2.91542288557214	NFKBIA/TNF/CXCL3/CCL3/CXCL2/SOD2/ABCG1/CD14/JUN/CCL5/TICAM1/BAX/FOS/NCF1/PPARG/FAS/LY96/MAP2K3	4.88523359565949
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	10/268	78/9376	4.48526597780329	TNF/ITGB2/SERPING1/CD14/IRF1/JUN/C2/TICAM1/FOS/LY96	5.30188106942982
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	16/268	187/9376	2.99337536914359	NFKBIA/GBP2/GBP5/TNF/CXCL3/CXCL2/GBP1/P2RX7/MAP1LC3B/JUN/GABARAP/GBP4/CCL5/TICAM1/CTSB/RIPK2	4.72299286410494
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	8/268	51/9376	5.48785484342991	GNAS/ATP6V0C/ATP6V0E1/ATP6V0A1/ATP6V0B/ATP6V0D2/ATP6AP1/ATP6V1B2	5.51240342101459
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	8/268	52/9376	5.38231917336395	APOC1/CYP27A1/LIPA/MYLIP/PLTP/APOE/NPC2/TSPO	5.43558220998612
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	8/268	54/9376	5.18297401879491	HLA-DRB5/HLA-C/HLA-DQA2/HLA-A/HLA-DMB/HLA-E/HLA-F/FAS	5.28772696459862
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	9/268	70/9376	4.49808102345416	HLA-DRB5/HLA-C/HLA-DQA2/HLA-A/ITGB2/HLA-DMB/HLA-E/HLA-F/DTNA	5.03893649050312
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	7/268	42/9376	5.83084577114428	FTH1/SAT1/MAP1LC3B/FTL/PCBP2/SLC3A2/LPCAT3	5.38214561680893
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	8/268	56/9376	4.99786780383795	NFKBIA/TNF/CXCL3/CXCL2/ITGB2/CD14/EEF1A1/VCP	5.14702183824383
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	10/268	94/9376	3.72181644966656	NFKBIA/TNF/CXCL3/CXCL2/CXCL10/JUN/FOSL1/FOSB/FOS/JUND	4.54928875478911
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	16/268	214/9376	2.61570651415818	HLA-C/B2M/NFKBIA/HLA-A/TNF/CXCR4/JUN/HLA-E/HLA-F/BAX/AP1S2/FOS/TAP1/FAS/CUL1/MAP2K3	4.1012452760058
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	15/268	193/9376	2.71904725079267	NFKBIA/CXCL9/CXCL3/CCL3/CXCL2/CXCR4/CCL4/CXCL11/CXCL10/XCL1/CCL18/XCL2/CCL5/CXCL16/NCF1	4.13919322692509
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	13/268	157/9376	2.89685331305257	HLA-C/GADD45B/HLA-A/CDKN1A/HLA-E/HLA-F/ZFP36L2/SQSTM1/MDM2/MRAS/SERPINE1/RHEB/MAP2K3	4.11133807645734
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	10/268	103/9376	3.39660918707434	NFKBIA/TNF/CCL3/GNAS/JUN/CCL5/TICAM1/FOS/SERPINE1/FAS	4.19514741705327
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	10/268	105/9376	3.3319118692253	NFKBIA/GADD45B/TNF/TNFSF13B/CXCL3/CXCL2/CCL4/CD14/TICAM1/LY96	4.12178197973436
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	19/268	298/9376	2.2305920064109	CXCL9/TNF/TNFSF13B/CXCL3/CCL3/CXCL2/CXCR4/CCL4/CXCL11/CXCL10/XCL1/CCL18/XCL2/CCL5/CXCL16/GDF15/TNFRSF14/IL10RA/FAS	3.70312742803177
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	5/268	28/9376	6.24733475479744	ATP6V0C/ATP6V0E1/ATP6V0A1/ATP6V0D2/ATP6V1B2	4.76979769135001
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	12/268	163/9376	2.57558831608827	NFKBIA/TNF/CDKN1A/JUN/TICAM1/DDB2/BAX/FOS/EGR2/FAS/MAP2K3/ATP6AP1	3.48078775478619
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	11/268	144/9376	2.67247097844113	NFKBIA/TNF/CXCL3/CXCL2/CD14/C2/TICAM1/ALDH2/FAS/LY96/MAP2K3	3.46923295178338
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	9/268	105/9376	2.99872068230277	UBC/MAP1LC3B/JUN/GABARAP/MITF/SQSTM1/MRAS/PINK1/VCP	3.53284830338585
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	5/268	37/9376	4.72771278741428	GADD45B/CDKN1A/DDB2/BAX/PPARG	3.89703801287351
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	10/268	133/9376	2.63045673886208	HLA-C/HLA-A/TNF/ITGB2/HLA-E/MICA/KLRD1/FCGR3A/KLRC1/FAS	3.24840483555205
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	15/268	248/9376	2.11603273952817	S100A10/NFKBIA/TNF/CD14/JUN/DYNLT1/ANXA2/PLEKHM2/BAX/AHNAK/RIPK2/FOS/LY96/MAP2K3/FLNA	3.05531846000447
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	7/268	75/9376	3.2652736318408	GADD45B/CDKN1A/DDB2/BAX/MDM2/SERPINE1/FAS	3.37853174155422
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	17/268	300/9376	1.98248756218905	GADD45B/TNF/MAP3K8/RAPGEF2/CD14/JUN/EREG/MRAS/FOS/RPS6KA2/DUSP10/JUND/FAS/DUSP1/MAP2K3/NR4A1/FLNA	2.9667569547514
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	15/268	253/9376	2.07421391068374	UBC/NFKBIA/TNF/CD14/MAP1LC3B/JUN/CCL5/SQSTM1/WIPI1/BAX/RIPK2/MDM2/RRAGD/CTTN/CUL1	2.97114412672605
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	11/268	160/9376	2.40522388059702	HLA-DRB5/HLA-C/HLA-DQA2/HLA-A/CD99/ITGB2/HLA-DMB/HLA-E/HLA-F/PTPRM/SDC3	3.07521726468364
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	7/268	77/9376	3.18046132971506	NFKBIA/GADD45B/CDKN1A/DDB2/BAX/MDM2/GAB2	3.29546840226541
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	7/268	79/9376	3.09994332136784	VAMP2/ATP6V0C/ATP6V0E1/ATP6V0A1/ATP6V0B/ATP6V0D2/ATP6V1B2	3.21507588113008
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	8/268	99/9376	2.8270767375245	MMP2/CDKN1A/GNAS/JUN/BAX/MDM2/FOS/JAG1	3.13481655357434
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	8/268	99/9376	2.8270767375245	HLA-DRB5/HLA-DQA2/ITGB2/CFD/HLA-DMB/C2/FCGR3A/FCGR2A	3.13481655357434
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	10/268	142/9376	2.46373764977927	TNF/MMP2/JUN/GSTO1/SQSTM1/KLF2/GSTO2/FOS/NCF1/DUSP1	3.01476875137758
Organismal Systems	Digestive system	hsa04978	Mineral absorption	6/268	61/9376	3.44115488133105	MT2A/FTH1/MT1X/FTL/ATOX1/ATP1B1	3.28103109753754
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	8/268	100/9376	2.79880597014925	HLA-DRB5/HLA-DQA2/TNF/HLA-DMB/CD14/CD9/CD7/CD38	3.10202629268217
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	3/268	15/9376	6.99701492537313	HEXB/ST3GAL1/HEXA	3.98713702174467
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	11/268	169/9376	2.27713503488475	UBC/CTSD/LAMP1/MAP1LC3B/GABARAP/CTSB/SQSTM1/WIPI1/MRAS/RRAGD/RHEB	2.87384025471447
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	8/268	103/9376	2.71728734965947	FN1/TNF/CXCL3/CXCL2/ITGB2/GNAS/CD14/PRDX1	3.00602769450985
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	3/268	16/9376	6.55970149253731	HEXB/ST3GAL1/HEXA	3.81781663194205
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	8/268	105/9376	2.66552949538024	NFKBIA/TNF/IRF1/JUN/CLEC4E/MDM2/MRAS/EGR2	2.94391462703734
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	11/268	173/9376	2.22448451384695	HLA-DRB5/HLA-DQA2/NFKBIA/TNF/HLA-DMB/CXCL10/RAB11A/CCL5/TICAM1/BAX/FAS	2.7883877218452
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	7/268	87/9376	2.81489106193172	GADD45B/CDKN1A/JUN/EREG/DDB2/BAX/FOS	2.91720689197988
Human Diseases	Immune disease	hsa05310	Asthma	4/268	32/9376	4.37313432835821	HLA-DRB5/HLA-DQA2/TNF/HLA-DMB	3.27856452187081
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	12/268	201/9376	2.08866117175317	GADD45B/CDKN1A/ID2/NUPR1/CD14/MITF/DDB2/BAX/NFKBIZ/MDM2/PPARG/ETV7	2.67626583600029
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	5/268	50/9376	3.49850746268657	HLA-DRB5/HLA-DQA2/TNFSF13B/CXCR4/HLA-DMB	3.0385016170415
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	12/268	205/9376	2.04790680742628	HLA-C/NFKBIA/HLA-A/CDKN1A/SCIN/JUN/HLA-E/HLA-F/BAX/MDM2/EGR2/ATP6V0D2	2.60215264824612
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	8/268	112/9376	2.49893390191898	HLA-DRB5/HLA-DQA2/NFKBIA/TNF/HLA-DMB/IL10RA/LY96/MAP2K3	2.73737152131553
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	3/268	19/9376	5.52395915161037	HEXB/GNS/HEXA	3.38585756842215
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	7/268	93/9376	2.63328518696838	HLA-DRB5/HLA-DQA2/NFKBIA/HLA-DMB/JUN/FOS/JAG1	2.71519388295851
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	9/268	138/9376	2.28163530175211	FN1/NFKBIA/TNF/JUN/TICAM1/FOS/RPS6KA2/FCGR2A/MAP2K3	2.60169600291857
Human Diseases	Cancer: specific types	hsa05218	Melanoma	6/268	73/9376	2.87548558576978	GADD45B/CDKN1A/MITF/DDB2/BAX/MDM2	2.75933973246848
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	5/268	55/9376	3.18046132971506	PSAP/HEXB/ASAH1/HEXA/SGMS2	2.78189032380249
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	6/268	75/9376	2.79880597014925	CDKN1A/GSTO1/BAX/GSTO2/MDM2/FAS	2.6828207337177
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	6/268	76/9376	2.76197957580518	UBC/FABP5/CYP27A1/PLTP/PLIN2/PPARG	2.6454996964452
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	7/268	98/9376	2.49893390191898	SCIN/NCF1/PLD1/FCGR3A/GAB2/FCGR2A/ASAP2	2.55864397817286
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	7/268	101/9376	2.42470814245604	FN1/TNF/MMP2/EGR1/JUN/BAX/SERPINE1	2.46928465960367
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	7/268	102/9376	2.40093649400059	GNAS/PLA2G2D/RAB11A/ATP1B1/KCNMA1/PLA2G12B/CD38	2.44020612580639
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	6/268	88/9376	2.3853459972863	ITGB2/SERPING1/CFD/VSIG4/C2/SERPINE1	2.23964926080329
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	5/268	66/9376	2.65038444142922	HLA-DRB5/HLA-DQA2/TNF/HLA-DMB/JUN	2.30793605750049
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	7/268	115/9376	2.1295262816353	CDKN1A/GNAS/EGR1/MAFB/FOS/PLD1/JUND	2.09053692461902
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	6/268	93/9376	2.25710158883004	MMP2/GNAS/EGR1/JUN/PLD1/MAP2K3	2.08982152748492
Organismal Systems	Digestive system	hsa04970	Salivary secretion	6/268	93/9376	2.25710158883004	GNAS/VAMP2/ATP1B1/LYZ/KCNMA1/CD38	2.08982152748492
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	6/268	93/9376	2.25710158883004	FN1/NFKBIA/GADD45B/CDKN1A/DDB2/BAX	2.08982152748492
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	5/268	72/9376	2.42951907131012	NFKBIA/TNF/ISG15/CXCL10/ZNFX1	2.08863655784786
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/268	14/9376	4.99786780383795	B4GALT1/ST3GAL1	2.56773176096419
Human Diseases	Cancer: specific types	hsa05214	Glioma	5/268	76/9376	2.30164964650432	GADD45B/CDKN1A/DDB2/BAX/MDM2	1.95434373473459
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	7/268	125/9376	1.95916417910448	CTSD/TNF/ASAH1/BAX/PLD1/SGMS2/GAB2	1.85180452728089
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	3/268	33/9376	3.18046132971506	VAMP5/VAMP2/STX5	2.15230447502347
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	10/268	204/9376	1.71495463857185	FN1/TNF/MMP2/CDKN1A/CD63/MDM2/MRAS/CTTN/FAS/FLNA	1.770936842587
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	5/268	77/9376	2.27175809265361	GADD45B/CDKN1A/DDB2/BAX/PLD1	1.92208802447003
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	3/268	34/9376	3.08691834942932	POLR2A/POLR2J3/POLR2E	2.0910600697025
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	11/268	238/9376	1.61695723065346	NFKBIA/TNF/ISG15/CFD/CXCL10/JUN/RPS27L/C2/FOS/ADAM17/FCGR2A	1.65371050181531
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	4/268	59/9376	2.37186946622818	GADD45B/CDKN1A/DDB2/BAX	1.81318564634927
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	5/268	83/9376	2.10753461607625	NFKBIA/CCL4/CXCL10/CCL5/POLR2E	1.73844081940103
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	6/268	109/9376	1.92578392441462	HLA-DRB5/HLA-DQA2/NFKBIA/HLA-DMB/JUN/FOS	1.66761129110803
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	2/268	18/9376	3.88723051409619	HEXB/HEXA	2.10313773342562
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	2/268	18/9376	3.88723051409619	TCN2/PRDX1	2.10313773342562
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	3/268	38/9376	2.76197957580518	HEXB/HEXA/AMDHD2	1.86684068744264
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	7/268	138/9376	1.77460523469608	ATP6V0C/ATP6V0E1/ATP6V0A1/ATP6V0B/ATP6V0D2/ATP6AP1/ATP6V1B2	1.57243432682724
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	11/268	250/9376	1.53934328358209	HLA-C/HLA-A/CXCR4/FOLR2/ARF5/HLA-E/RAB11A/HLA-F/MDM2/PLD1/ASAP2	1.48264293077414
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	4/268	63/9376	2.22127457948353	POLR2A/DDB2/POLR2J3/POLR2E	1.6683236830328
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	4/268	63/9376	2.22127457948353	GADD45B/CDKN1A/DDB2/BAX	1.6683236830328
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	8/268	168/9376	1.66595593461265	FTH1/TNF/FTL/TICAM1/SQSTM1/BAX/GLUL/FAS	1.4940289166455
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	3/268	41/9376	2.55988350928285	MMP2/CDKN1A/MDM2	1.71699273790965
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	5/268	90/9376	1.94361525704809	NFKBIA/JUN/TICAM1/FOS/MAP2K3	1.54291994657106
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	7/268	143/9376	1.7125561006158	HLA-DRB5/HLA-DQA2/TNF/HLA-DMB/C2/FCGR3A/FCGR2A	1.47284548541634
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	5/268	91/9376	1.92225684762998	NFKBIA/JUN/IFITM1/FOS/LILRB4	1.51643274878927
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	9/268	200/9376	1.57432835820896	NFKBIA/TNF/JUN/BAX/FOS/CTTN/FAS/TMBIM6/FCGR2A	1.40828346543971
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/268	22/9376	3.18046132971506	ALDH2/HNMT	1.75631564821408
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	3/268	44/9376	2.3853459972863	HEXB/B4GALT1/HEXA	1.57993329603248
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	3/268	44/9376	2.3853459972863	GNAS/VAMP2/RAB11A	1.57993329603248
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	7/268	148/9376	1.654699475595	GADD45B/CDKN1A/JUN/DDB2/BAX/FOS/JAG1	1.37708447472631
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	4/268	69/9376	2.0281202682241	GNAS/JUN/FOSB/FOS	1.47029721130375
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	3/268	45/9376	2.33233830845771	ABCG1/TAP1/ABCA6	1.53673223641614
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/268	23/9376	3.04218040233614	ATP6AP2/CTSA	1.68199259421026
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/268	46/9376	2.28163530175211	FTH1/FTL/BLVRB	1.49466573829971
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	7/268	154/9376	1.59023066485753	CDKN1A/GNAS/RCAN1/JUN/FOS/EEF2/CD38	1.26680886778737
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	4/268	73/9376	1.91699039051319	GADD45B/CDKN1A/DDB2/BAX	1.34913754498213
NA	NA	hsa03272	Virion - Hepatitis viruses	3/268	48/9376	2.1865671641791	CD63/LAMP1/CD9	1.41370957731302
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	7/268	156/9376	1.56984309223115	NFKBIA/TNF/CDKN1A/CXCL10/TICAM1/BAX/FAS	1.23110090599678
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	6/268	128/9376	1.63992537313433	ADA2/GUK1/GMPR/PDE8A/ENPP4/NUDT2	1.25040853345476
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	3/268	49/9376	2.14194334450198	GNAS/JUN/FOSB	1.37471646283751
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	7/268	158/9376	1.54997166068392	TNF/RPS6KA2/SLC3A2/RRAGD/CAB39L/RHEB/ATP6V1B2	1.19589218344518
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/268	26/9376	2.69115958668197	PLA2G2D/PLA2G12B	1.48117708528021
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	5/268	104/9376	1.68197474167623	PLA2G2D/PLD1/SGMS2/PLA2G12B/LPCAT3	1.19960915749493
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/268	51/9376	2.05794556628622	PLA2G2D/PLD1/PLA2G12B	1.29946777743513
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	6/268	133/9376	1.57827404331725	GADD45B/CDKN1A/SOD2/GABARAP/KLF2/MDM2	1.15211164688552
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	5/268	105/9376	1.66595593461265	LMNA/TNF/GNAS/EMD/DTNA	1.1771135979918
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	3/268	53/9376	1.98028724303013	GNAS/RAB11A/ATP1B1	1.22759459589025
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	5/268	110/9376	1.59023066485753	TNF/ID2/EMP3/TGIF1/CUL1	1.06810386842666
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/268	30/9376	2.33233830845771	PLA2G2D/PLA2G12B	1.2537293085162
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/268	30/9376	2.33233830845771	TNF/FOLR2	1.2537293085162
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	6/268	140/9376	1.49936034115139	MAP1LC3B/EGR1/KLF2/MRAS/SERPINE1/JAG1	1.02112198787748
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	7/268	174/9376	1.40744553096586	PPP1R15A/SSR3/BAX/CUL1/CRYAB/BCAP31/VCP	0.930560454367211
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	4/268	86/9376	1.62721277334259	GNAS/VAMP2/ATP1B1/KCNMA1	1.00230013106551
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	2/268	32/9376	2.1865671641791	B4GALT1/GAA	1.15330035172004
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	2/268	32/9376	2.1865671641791	GABARAP/WIPI1	1.15330035172004
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	5/268	116/9376	1.50797735460628	CD99/MMP2/ITGB2/CXCR4/NCF1	0.944298669090489
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/268	10/9376	3.49850746268657	SQOR	1.35595444303587
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/268	34/9376	2.05794556628622	BHLHE40/CUL1	1.06004517626904
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	4/268	90/9376	1.55489220563847	SOD2/BAX/PPARG/RHEB	0.907312854345655
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	5/268	120/9376	1.45771144278607	NFKBIA/JUN/BAX/RIPK2/RPS6KA2	0.865590027408064
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	3/268	62/9376	1.69282619162253	ADAM17/TLE1/JAG1	0.93884424748546
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	3/268	63/9376	1.66595593461265	LTA4H/PLA2G2D/PLA2G12B	0.909729946266768
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	5/268	122/9376	1.43381453388794	NFKBIA/TNF/MAP3K8/JUN/FOS	0.827295743562382
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	8/268	217/9376	1.28977233647431	GNAS/JUN/GSTO1/KLF4/GSTO2/FOS/RPS6KA2/JAG1	0.740805647028368
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	3/268	65/9376	1.61469575200918	GNAS/PDE8A/NR4A1	0.853022037378175
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	2/268	37/9376	1.89108511496571	TNF/FAS	0.931561191476851
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	6/268	157/9376	1.33700922140888	TNF/JUN/BAX/FOS/PPARG/FAS	0.730451234453029
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/268	38/9376	1.84131971720346	ATP1B1/NR3C2	0.891389378622855
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	4/268	99/9376	1.41353836876225	JUN/FOS/PLD1/RHEB	0.709530638373994
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	4/268	99/9376	1.41353836876225	LMNA/TNF/EMD/DTNA	0.709530638373994
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	5/268	130/9376	1.34557979334099	NFKBIA/MMP2/GNAS/JUN/FOS	0.680588484242197
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	3/268	69/9376	1.52109020116807	TNF/GAB2/MAP2K3	0.745202184311117
Organismal Systems	Endocrine system	hsa04924	Renin secretion	3/268	69/9376	1.52109020116807	GNAS/CTSB/KCNMA1	0.745202184311117
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	8/268	226/9376	1.23840972130498	NFKBIA/GNAS/JUN/CNGA1/ATP1B1/FOS/PLD1/SUCNR1	0.622313406138557
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	8/268	227/9376	1.23295417187192	NFKBIA/SOD2/JUN/GSTO1/GSTO2/FOS/NCF1/PLD1	0.609450070304479
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/268	70/9376	1.49936034115139	GSTO1/GSTO2/SULT1A1	0.719321544603091
Human Diseases	Infectious disease: viral	hsa05162	Measles	5/268	136/9376	1.28621597892888	NFKBIA/JUN/BAX/FOS/FAS	0.576725120972461
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/268	43/9376	1.62721277334259	PLA2G2D/PLA2G12B	0.707098658651288
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	6/268	170/9376	1.23476733977173	GADD45B/CDKN1A/GSTO1/DDB2/BAX/GSTO2	0.529868593293323
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	4/268	106/9376	1.32019149535342	NFKBIA/CDKN1A/FOLR2/MDM2	0.568675321989939
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	5/268	139/9376	1.2584559218297	CTSD/MMP2/GNAS/JUN/FOS	0.526586765409347
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	4/268	109/9376	1.28385594960975	NFKBIA/TNF/RPS6KA2/OGA	0.511308712685542
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	5/268	142/9376	1.23186882488964	UBC/UBE2B/DDB2/MDM2/CUL1	0.477565694782345
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/268	17/9376	2.05794556628622	CYP27A1	0.748884055517166
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/268	17/9376	2.05794556628622	GLUL	0.748884055517166
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/268	17/9376	2.05794556628622	LAMP1	0.748884055517166
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3/268	79/9376	1.32854713772908	DHDH/GSTO1/GSTO2	0.50301547074091
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	3/268	82/9376	1.27994175464143	GSTO1/GSTO2/CES1	0.436731781035338
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	2/268	50/9376	1.39940298507463	SAT1/ALDH2	0.485724631254663
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	2/268	50/9376	1.39940298507463	TNF/ITGB2	0.485724631254663
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	5/268	149/9376	1.17399579284784	GNAS/MRAS/PLD1/RHEB/GAB2	0.36723422184638
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/268	19/9376	1.84131971720346	OGDH	0.629667208852253
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	3/268	85/9376	1.23476733977173	ADA2/GUK1/GMPR	0.372955860511129
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/268	20/9376	1.74925373134328	LIPA	0.575360879987058
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	3/268	86/9376	1.22040958000694	CDKN1A/JUN/EREG	0.352219470518319
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	3/268	86/9376	1.22040958000694	LMNA/EMD/DTNA	0.352219470518319
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/268	21/9376	1.66595593461265	ALDH2	0.524052466227299
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	4/268	122/9376	1.14705162711035	PPARG/CAB39L/RHEB/EEF2	0.280431326498021
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	4/268	122/9376	1.14705162711035	RCAN1/ATP1B1/MDM2/RHEB	0.280431326498021
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	4/268	122/9376	1.14705162711035	GNAS/JUNB/FOS/MAP2K3	0.280431326498021
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	5/268	157/9376	1.11417435117407	TIMD4/LIPA/ADAM17/PPARG/SIRPA	0.247467399880984
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/268	23/9376	1.52109020116807	GLUL	0.429183366110847
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/268	23/9376	1.52109020116807	B4GALT1	0.429183366110847
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/268	23/9376	1.52109020116807	ATP1B1	0.429183366110847
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	7/268	233/9376	1.05105374415476	FN1/LMNA/VIM/ATP1B1/EMD/DTNA/SDC3	0.135363857644595
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	2/268	59/9376	1.18593473311409	GSTO1/GSTO2	0.245748008494692
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/268	26/9376	1.34557979334099	TCN2	0.302670945464591
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	2/268	62/9376	1.12855079441502	SOD2/CRYAB	0.174198341958734
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	3/268	98/9376	1.07097167225099	GNAS/ATP1B1/NR4A1	0.121146930890932
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	4/268	134/9376	1.04433058587659	GNAS/PLA2G2D/KCNMA1/PLA2G12B	0.0886572818990468
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/268	28/9376	1.24946695095949	B4GALT1	0.22676405115317
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/268	29/9376	1.20638188368502	CNGA1	0.19093079191642
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/268	30/9376	1.16616915422886	OGDH	0.15636504445273
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/268	68/9376	1.02897278314311	ALDH1A1/DHRS9	0.0411299336663703
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/268	31/9376	1.12855079441502	ALDH2	0.122972353016888
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/268	31/9376	1.12855079441502	ALDH2	0.122972353016888
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/268	31/9376	1.12855079441502	GLUL	0.122972353016888
NA	NA	hsa04981	Folate transport and metabolism	1/268	31/9376	1.12855079441502	FOLR2	0.122972353016888
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	2/268	70/9376	0.999573560767591	NFKBIA/TNF	-0.000614279713580827
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	2/268	70/9376	0.999573560767591	CDKN1A/JUN	-0.000614279713580827
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/268	32/9376	1.09328358208955	BAX	0.0906682666446575
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	2/268	71/9376	0.985495059911709	IRF1/FOS	-0.0210440075620355
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	10/268	368/9376	0.950681375730045	TNF/MAP1LC3B/SQSTM1/WIPI1/BAX/PSMA6/MAP2K3/PINK1/SRSF7/VCP	-0.165562584915987
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/268	33/9376	1.06015377657169	OGDH	0.0593769954735783
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/268	73/9376	0.958495195256594	GSTO1/GSTO2	-0.0610646425042081
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	4/268	150/9376	0.932935323383085	GADD45B/CDKN1A/DDB2/BAX	-0.142028095473749
NA	NA	hsa04517	IgSF CAM signaling	8/268	299/9376	0.936055508411122	ITGB2/RAPGEF2/SLAMF7/MBP/CD84/LY9/CRTAM/NPHS1	-0.19275652550148
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	2/268	75/9376	0.932935323383085	GNAS/ATP1B1	-0.100023297628373
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	2/268	76/9376	0.920659858601728	GNAS/ATP1B1	-0.11912415039722
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/268	36/9376	0.971807628524046	DHDH	-0.0290703958616737
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/268	36/9376	0.971807628524046	GAA	-0.0290703958616737
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/268	36/9376	0.971807628524046	ST3GAL1	-0.0290703958616737
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	3/268	116/9376	0.904786412763767	GNAS/PLD1/GLUL	-0.176996204439453
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	4/268	155/9376	0.902840635532017	CDKN1A/GNAS/PDE8A/NR4A1	-0.209219918065885
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	6/268	232/9376	0.904786412763767	FN1/ITGB2/CXCR4/SCIN/MRAS/IQGAP2	-0.251893137456638
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	2/268	78/9376	0.897053195560658	PABPC4/BTG1	-0.156605469164008
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	2/268	78/9376	0.897053195560658	FN1/CTTN	-0.156605469164008
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/268	37/9376	0.945542557482856	GLUL	-0.0569310823220348
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	8/268	308/9376	0.908703237061446	SOD2/POLR2A/WIPI1/BAX/POLR2J3/PPARG/PSMA6/POLR2E	-0.279457973882549
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	4/268	158/9376	0.885698091819384	GADD45B/CDKN1A/MDM2/CUL1	-0.248545094807397
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/268	38/9376	0.920659858601728	CD38	-0.0840619301969265
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/268	38/9376	0.920659858601728	TAP1	-0.0840619301969265
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	2/268	83/9376	0.843013846430498	SOD2/PRDX1	-0.246413189695908
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/268	42/9376	0.832977967306325	ALDH2	-0.186082715896734
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/268	43/9376	0.813606386671295	ALDH2	-0.21013391239388
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	4/268	170/9376	0.823178226514486	RAPGEF2/JUN/YBX3/CTTN	-0.399085769219429
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/268	44/9376	0.795115332428765	POLG2	-0.233663004604215
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	2/268	89/9376	0.786181452289116	GABARAP/GLUL	-0.347651558159499
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	5/268	212/9376	0.825119684595889	ITGB2/GNAS/RAPGEF2/MRAS/MAP2K3	-0.441781822344527
Organismal Systems	Digestive system	hsa04976	Bile secretion	2/268	90/9376	0.777446102819237	GNAS/ATP1B1	-0.363901330105161
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	1/268	46/9376	0.760545100584036	PSMA6	-0.279256535408907
Human Diseases	Substance dependence	hsa05032	Morphine addiction	2/268	91/9376	0.768902739051993	GNAS/PDE8A	-0.379984659975829
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/268	47/9376	0.744363289933312	ALDH2	-0.301367299441476
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/268	47/9376	0.744363289933312	TNF	-0.301367299441476
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/268	48/9376	0.728855721393035	ALDH2	-0.323048939050563
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/268	48/9376	0.728855721393035	ATP1B1	-0.323048939050563
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	4/268	178/9376	0.786181452289116	JUN/FOSL1/CUL1/TLE1	-0.494026446228548
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	1/268	49/9376	0.713981114833993	B4GALT1	-0.344320821180161
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	3/268	138/9376	0.760545100584036	CPEB4/RPS6KA2/CUL1	-0.486089025355419
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	2/268	97/9376	0.721341744883828	GNAS/FOS	-0.47320433809271
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/268	52/9376	0.672789896670494	GNAS	-0.405853007557256
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	2/268	99/9376	0.706769184381125	GNAS/MAP2K3	-0.503112319226182
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	6/268	268/9376	0.78324793940744	UBC/GNAS/BAX/PSMA6/DUSP1/PINK1	-0.617533674817582
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	2/268	101/9376	0.692773754987439	GNAS/MITF	-0.532480324376726
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	2/268	103/9376	0.679321837414867	ATP1B1/SLC3A2	-0.561331473120436
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	6/268	275/9376	0.763310719131615	TNF/EGR1/CCL5/BAX/NCF1/PSMA6	-0.68334796292581
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	1/268	56/9376	0.624733475479744	B4GALT1	-0.483133783216487
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	1/268	56/9376	0.624733475479744	CUL1	-0.483133783216487
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	5/268	235/9376	0.744363289933312	GNAS/RPS6KA2/PPARG/RHEB/MAP2K3	-0.680772212604441
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	4/268	195/9376	0.717642556448527	ITGB2/NCF1/FCGR3A/FCGR2A	-0.683459960890484
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	5/268	238/9376	0.734980559387934	PLA2G2D/MRAS/PLD1/PLA2G12B/GAB2	-0.71036598705748
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	11/268	480/9376	0.801741293532338	UBC/TNF/MAP1LC3B/SQSTM1/WIPI1/BAX/FAS/PSMA6/MAP2K3/PINK1/VCP	-0.764886549826125
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/268	59/9376	0.592967366557045	NUDT2	-0.537970810432599
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1/268	59/9376	0.592967366557045	GNAS	-0.537970810432599
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	3/268	154/9376	0.681527427796085	GNAS/ATP1B1/KCNE1	-0.68353595066491
NA	NA	hsa04518	Integrin signaling	3/268	154/9376	0.681527427796085	FN1/ITGB2/FLNA	-0.68353595066491
Organismal Systems	Nervous system	hsa04730	Long-term depression	1/268	60/9376	0.583084577114428	GNAS	-0.555712762251097
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	2/268	110/9376	0.636092265943012	CDKN1A/SERPINE1	-0.658541281636852
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	2/268	110/9376	0.636092265943012	CPEB4/RPS6KA2	-0.658541281636852
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	3/268	157/9376	0.66850461070444	ITGB2/ID2/SERPINE1	-0.718500269263106
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	4/268	203/9376	0.689361076391442	FN1/EMP1/JUN/FLNA	-0.767520031802874
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/268	63/9376	0.555318644870884	ALDH2	-0.607457527265288
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	2/268	115/9376	0.608436080467229	GNAS/DUSP1	-0.724709858850462
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/268	65/9376	0.538231917336395	ALDH2	-0.640802135662125
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/268	66/9376	0.530076888285844	DHRS9	-0.657151428814197
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	1/268	67/9376	0.522165292938294	ALDH2	-0.673294553854023
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	1/268	67/9376	0.522165292938294	RPS6KA2	-0.673294553854023
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	3/268	166/9376	0.632260384822874	CNGA1/ATP1B1/KCNMA1	-0.819985495681025
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	1/268	68/9376	0.514486391571554	CD14	-0.689237979318266
Organismal Systems	Immune system	hsa04611	Platelet activation	2/268	126/9376	0.555318644870884	GNAS/FCGR2A	-0.861995206800156
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	1/268	73/9376	0.479247597628297	CXCR4	-0.766165736247379
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/268	75/9376	0.466467661691542	GLUL	-0.795734305464892
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	2/268	133/9376	0.526091347772416	GNAS/FOS	-0.94418154178101
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	1/268	80/9376	0.437313432835821	BAX	-0.866971872495444
Human Diseases	Substance dependence	hsa05034	Alcoholism	3/268	191/9376	0.54950378995077	GNAS/FOSB/SLC29A1	-1.07897099284652
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	1/268	87/9376	0.402127294561674	ATP1B1	-0.96100444451743
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	2/268	144/9376	0.485903814262023	ID2/KLF4	-1.06639783346837
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	2/268	144/9376	0.485903814262023	WIPI1/PSMA6	-1.06639783346837
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	1/268	89/9376	0.393090726144558	FN1	-0.986785089395471
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	1/268	89/9376	0.393090726144558	GNAS	-0.986785089395471
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	7/268	388/9376	0.63117402677335	TNF/RTN4/APOE/WIPI1/ADAM17/FAS/PSMA6	-1.27276244498702
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	1/268	93/9376	0.376183598138341	PTPRM	-1.03704024988304
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	4/268	254/9376	0.550946057115995	CXCR4/GNAS/P2RX7/CD38	-1.2445486058029
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	3/268	205/9376	0.511976701856571	CTSD/MMP2/NCF1	-1.21185501293641
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	1/268	103/9376	0.339660918707434	PABPC4	-1.15589133439215
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	6/268	362/9376	0.579863115362414	FN1/CDKN1A/EREG/MDM2/RHEB/NR4A1	-1.39838849883854
NA	NA	hsa04382	Cornified envelope formation	3/268	217/9376	0.483664626177866	S100A10/S100A6/S100A4	-1.32001613867599
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	2/268	168/9376	0.416488983653163	CDKN1A/IL10RA	-1.30906909345353
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	1/268	107/9376	0.326963314269773	GNAS	-1.20103512639886
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	1/268	108/9376	0.323935876174682	EEF1A1	-1.21212743094119
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	1/268	115/9376	0.304218040233615	FOS	-1.28775921554436
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	1/268	116/9376	0.301595470921256	OGDH	-1.2982910779694
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	2/268	184/9376	0.380272550292018	CXCR4/SEMA4A	-1.4562842775458
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	1/268	138/9376	0.253515033528012	RHEB	-1.51535070144675
Genetic Information Processing	Translation	hsa03010	Ribosome	2/268	222/9376	0.315180852494285	RPS27L/MRPL23	-1.77128502959744
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	1/268	154/9376	0.227175809265362	ALDH2	-1.65870835989105
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	1/268	183/9376	0.191175271185058	NOP10	-1.89536501402804
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	3/268	323/9376	0.324938773624139	VIM/CDKN1A/MDM2	-2.11782314018595
Cellular Processes	Cell motility	hsa04814	Motor proteins	1/268	194/9376	0.180335436220957	DYNLT1	-1.9788364653878
NA	NA	hsa04082	Neuroactive ligand signaling	1/268	199/9376	0.175804395109878	GNAS	-2.01580255286815
NA	NA	hsa04519	Cadherin signaling	4/268	404/9376	0.346386877493719	NFKBIA/VIM/MRAS/MAP2K3	-2.30360672244251
NA	NA	hsa04081	Hormone signaling	1/268	219/9376	0.159749199209432	GNAS	-2.15822097813161
Genetic Information Processing	Transcription	hsa03040	Spliceosome	1/268	243/9376	0.143971500522081	SRSF7	-2.31913567131693
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	2/268	370/9376	0.189108511496571	P2RX7/TSPO	-2.72985234328884