category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	37/1078	82/9376	3.9245214715598	B2M/HLA-DRA/HLA-A/CD74/TAP1/HLA-C/KLRC1/HLA-DRB5/KLRC2/TAP2/KLRC3/CTSL/HLA-F/HLA-DPA1/HSPA5/HLA-B/KIR2DL4/HLA-DPB1/HSP90AA1/HLA-DQA2/HLA-DQA1/TNF/CTSS/PDIA3/KLRC4/IFNG/HLA-DRB1/HSPA1A/HLA-DQB1/HLA-E/HLA-DMA/CD8A/CALR/HSP90AB1/CD4/TAPBP/KIR2DL3	9.58669056784335
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	67/1078	227/9376	2.56712953503388	B2M/HLA-A/PDGFRA/CCL4/AKT3/ADCY3/PRKCA/CCL3/TAP1/HLA-C/ITPR2/CDKN2A/GNG2/PPP3CA/RAC2/CDK6/TAP2/ADCY1/HLA-F/PTGER4/AKAP13/MYC/CXCL8/HLA-B/FASLG/PTGER2/CCL5/CALML4/PRKCB/TNF/PIK3R1/IL10RA/NFATC2/PDIA3/PIK3CD/CREB3L2/IL1B/GNAI2/ADCY5/CCL3L1/GNGT2/CCL2/E2F1/HLA-E/CTNNB1/RAC3/GNAQ/PLCB4/MAPK12/GNG11/NFATC4/IRF3/BID/MDM2/CXCL12/CALM3/ITPR3/CCL4L2/CALR/GNB2/IKBKG/IL1R1/FAS/GNGT1/TAPBP/ITGAV/BAX	8.61468325324319
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	47/1078	133/9376	3.07358377390601	HLA-A/PRKCA/GZMB/HLA-C/FCER1G/KLRC1/ITGB2/PPP3CA/CD48/TYROBP/RAC2/KLRK1/CD247/KLRC2/HCST/KLRC3/LCP2/SH2D1A/PLCG2/PRF1/FYN/HLA-B/NCR3/FASLG/KIR2DL4/LCK/ITGAL/PRKCB/TNF/PIK3R1/NFATC2/ZAP70/PIK3CD/LAT2/IFNAR2/IFNG/NCR1/CSF2/FCGR3A/VAV3/HLA-E/RAC3/CD244/BID/ICAM1/FAS/KIR2DL3	8.68058977894599
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	59/1078	205/9376	2.50320828996787	B2M/VIM/HLA-DRA/HLA-A/AKT3/TAP1/HLA-C/CCND2/OAS2/STAT1/ISG15/TNFAIP3/CD247/CDK6/HLA-DRB5/TAP2/HLA-F/PLCG2/HLA-DPA1/MYC/RUNX3/HLA-B/HLA-DPB1/ITGAL/IRF9/GADD45A/HLA-DQA2/HLA-DQA1/TNF/PIK3R1/PDIA3/PIK3CD/IFNAR2/CD3E/HLA-DRB1/SAP30/NEDD4/OAS3/PSMD6/HLA-DQB1/E2F1/HLA-E/HLA-DMA/MAPK12/IRF3/BID/MDM2/PSMD13/CALR/PSMD11/JAK3/ICAM1/IKBKG/CIR1/FAS/TAPBP/OAS1/BAX/PSMD3	7.84324984077298
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	23/1078	45/9376	4.44543393114822	HLA-DRA/HLA-A/GZMB/HLA-C/KLRC1/HLA-DRB5/HLA-F/PRF1/HLA-DPA1/HLA-B/FASLG/HLA-DPB1/HLA-DQA2/HLA-DQA1/TNF/IL1B/IFNG/HLA-DRB1/HLA-DQB1/HLA-E/HLA-DMA/FAS/KIR2DL3	8.35015220803304
NA	NA	hsa04518	Integrin signaling	47/1078	154/9376	2.65445871382792	COL1A1/IGF1/COL6A1/COL6A3/PDGFRA/COL6A2/FN1/LAMA2/PDGFRB/AKT3/FBN1/CCND2/LAMB1/COL4A1/ITGB2/COL4A2/FLNA/RAC2/HGF/TNXB/THBS2/TGFB1/PARVG/COL4A6/ITGAL/ITGAX/ITGA1/COL4A5/COL1A2/LAMC3/PIK3R1/PIK3CD/ITGA5/ITGA4/TNC/CTNNB1/RAC3/ACTN1/ITGAM/ITGA9/PDGFD/ACTB/ICAM1/FERMT1/ARHGEF6/ITGAV/PARVA	7.46125767936
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	22/1078	44/9376	4.34879406307978	HLA-DRA/HLA-A/GZMB/HLA-C/HLA-DRB5/HLA-F/PRF1/HLA-DPA1/HLA-B/FASLG/HLA-DPB1/HLA-DQA2/HLA-DQA1/TNF/IL1B/IFNG/HLA-DRB1/HLA-DQB1/HLA-E/HLA-DMA/PTPRN2/FAS	8.02482772064966
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	34/1078	95/9376	3.11282101357289	HLA-DRA/CCL3/ITGB2/IL15/FOS/HLA-DRB5/CTSL/HLA-DPA1/TGFB1/CXCL8/HLA-DPB1/ITGAL/CCL5/CXCL3/ACP5/HLA-DQA2/HLA-DQA1/ATP6V0B/TNF/IL1B/IFNG/CSF2/HLA-DRB1/LTB/CCL3L1/CCL2/HLA-DQB1/HLA-DMA/CSF1/CXCL12/ANGPT1/ICAM1/CXCL2/CCL20	7.45994159429678
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	33/1078	93/9376	3.0862409479921	HLA-DRA/IL2RB/STAT1/PPP3CA/FOS/CD247/HLA-DRB5/IL2RG/HLA-DPA1/JAG1/MAF/RUNX3/HLA-DPB1/LCK/GATA3/STAT4/HLA-DQA2/HLA-DQA1/NFATC2/ZAP70/IFNG/CD3E/HLA-DRB1/HLA-DQB1/HLA-DMA/MAPK12/JAK3/MAML2/IKBKG/CD4/MAML3/JAG2/PRKCQ	7.2873573704645
Human Diseases	Immune disease	hsa05330	Allograft rejection	20/1078	39/9376	4.46030160315875	HLA-DRA/HLA-A/GZMB/HLA-C/HLA-DRB5/HLA-F/PRF1/HLA-DPA1/HLA-B/FASLG/HLA-DPB1/HLA-DQA2/HLA-DQA1/TNF/IFNG/HLA-DRB1/HLA-DQB1/HLA-E/HLA-DMA/FAS	7.80460416679134
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	58/1078	224/9376	2.2520540683806	B2M/HLA-DRA/HLA-A/AKT3/ADCY3/NRP1/HLA-C/CCND2/IL2RB/CDKN2A/ITGB2/PPP3CA/IL15/FOS/HLA-DRB5/ANAPC4/IL2RG/ADCY1/HLA-F/ETS1/HLA-DPA1/TGFB1/MYC/HLA-B/HLA-DPB1/LCK/ITGAL/HLA-DQA2/HLA-DQA1/TNF/PIK3R1/NFATC2/PIK3CD/CREB3L2/EGR1/CSF2/CD3E/HLA-DRB1/ADCY5/HLA-DQB1/E2F1/HLA-E/HLA-DMA/CDKN2C/CHEK1/LTBR/NFATC4/ATM/CALR/ZFP36/JAK3/PTTG1/ICAM1/RANBP1/IKBKG/IL1R1/CD4/BAX	6.83592659491136
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	27/1078	70/9376	3.35478399151869	HLA-DRA/HLA-A/LAMA2/HLA-C/ITGB2/RAC2/HLA-DRB5/HLA-F/PRF1/HLA-DPA1/FYN/SSPN/HLA-B/HLA-DPB1/ITGAL/HLA-DQA2/HLA-DQA1/DMD/HLA-DRB1/SNTB1/HLA-DQB1/HLA-E/RAC3/HLA-DMA/BID/ACTB/ICAM1	7.1273301083687
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	55/1078	214/9376	2.23536143429334	B2M/HLA-A/BST2/AKT3/PRKCA/TAP1/HLA-C/ITPR2/GNG2/PPP3CA/RAC2/APOBEC3G/FOS/CD247/TAP2/HLA-F/PLCG2/SAMHD1/HLA-B/FASLG/TNFRSF1B/CALML4/PRKCB/TNF/PIK3R1/NFATC2/PDIA3/PIK3CD/GNAI2/CD3E/APOBEC3H/GNGT2/HLA-E/RAC3/GNAQ/PAK3/MAPK12/GNG11/CDK1/CHEK1/NFATC4/IRF3/FBXW11/BID/CALM3/ATM/ITPR3/CALR/GNB2/IKBKG/CD4/FAS/GNGT1/TAPBP/BAX	6.58891774128718
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	51/1078	193/9376	2.2983263960318	CCL4/AKT3/ADCY3/CCL3/XCL1/XCL2/GNG2/STAT1/RAC2/ADCY1/ITK/ARRB1/PLCG2/CXCR3/DOCK2/CXCL8/CXCL13/GRK3/CCL5/PIK3CG/CXCL3/PRKCB/PIK3R1/PIK3CD/PIK3R5/GNAI2/NCF1/PREX1/PIK3R6/ADCY5/CCL3L1/GNGT2/CCL2/VAV3/GRK5/WAS/RAC3/GNAQ/PLCB4/GNG11/ELMO1/FGR/CXCL12/CCL4L2/GNB2/JAK3/IKBKG/CXCL2/GNGT1/CCL20/CCL15	6.568686763698
NA	NA	hsa04517	IgSF CAM signaling	69/1078	299/9376	2.00713572142144	NLGN1/SLIT3/AKT3/NRP1/PRKCA/MAGI2/NTRK3/ROBO1/PMP22/MYL9/CLMP/ITGB2/CD48/LCP2/SPTBN1/SH2D1A/PLCG2/TUBB6/FYN/CD96/UNC5C/JAM3/INPP5D/SLAMF7/APP/LCK/ITGAL/CD2/ITGAX/LRFN5/PRKCB/DOK2/SRGAP3/KIRREL1/CNTNAP1/PIK3R1/TIGIT/PIK3CD/NCAM1/MTSS1/ITGA5/ITGA4/MPDZ/PARD6G/MSN/VAV3/NLGN4X/CRTAM/CTNNB1/CASK/PAK3/MAPK12/CD244/KCNQ3/CDH2/ACTN1/ITGAM/NCAM2/MYLK3/PLXNA4/RAPGEF2/ACTB/MTSS2/ICAM1/ROBO2/ANK3/TJP2/PRKCQ/TRIO	6.37911938097559
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	35/1078	109/9376	2.79280352674848	HLA-DRA/RORA/IL2RB/STAT1/PPP3CA/FOS/CD247/HLA-DRB5/IL2RG/IL21R/HLA-DPA1/TGFB1/IL27RA/HLA-DPB1/LCK/GATA3/IRF4/HSP90AA1/HLA-DQA2/HLA-DQA1/NFATC2/ZAP70/IL1B/IFNG/CD3E/HLA-DRB1/HLA-DQB1/HLA-DMA/MAPK12/JAK3/HSP90AB1/IKBKG/IL1R1/CD4/PRKCQ	6.78554396451897
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	33/1078	100/9376	2.87020408163265	MME/HLA-DRA/CD7/HLA-DRB5/HLA-DPA1/CD37/HLA-DPB1/CD2/ITGA1/CD14/HLA-DQA2/HLA-DQA1/CD38/TNF/ANPEP/IL1B/IL7/ITGA5/ITGA4/CSF2/CD3E/HLA-DRB1/IL5RA/HLA-DQB1/GP1BB/HLA-DMA/CSF1/ITGAM/CR1L/CD8A/FLT3LG/IL1R1/CD4	6.77667930527176
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	33/1078	103/9376	2.78660590449772	COL3A1/COL1A1/FN1/LAMA2/PRKCA/LAMB1/COL4A1/ITGB2/COL4A2/ADCY1/TGFB1/CXCL8/COL4A6/COL4A5/CXCL3/COL1A2/CD14/LAMC3/PRKCB/TNF/PIK3R1/PIK3CD/IL1B/IFNG/CSF2/RAB7B/GNAQ/PLCB4/ACTN1/ITGAM/IL1R1/CXCL2/RAB5B	6.57121309221934
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	50/1078	196/9376	2.21877248116315	HLA-A/AKT3/CLEC2B/HLA-C/ITPR2/GNG2/STAT1/PPP3CA/FOS/CDK6/LEF1/HLA-F/FGF2/PLCG2/MYC/CXCL8/HLA-B/IRF9/CALML4/PIK3CG/CXCL3/PIK3R1/NFATC2/PIK3CD/PIK3R5/IFNAR2/PREX1/CSF2/PIK3R6/GNGT2/E2F1/HLA-E/CTNNB1/MAPK12/GNG11/NFATC4/IRF3/BID/CALM3/TCF7/ITPR3/GNB2/ZFP36/ICAM1/IKBKG/FAS/CXCL2/GNGT1/BAX/TCF7L2	6.21494998682257
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	43/1078	160/9376	2.33747680890538	HLA-DRA/HLA-A/NLGN1/HLA-C/ITGB2/PTPRC/HLA-DRB5/HLA-F/HLA-DPA1/SPN/VCAN/JAM3/HLA-B/HLA-DPB1/ITGAL/CD2/HLA-DQA2/HLA-DQA1/CNTNAP1/TIGIT/NCAM1/SELPLG/ITGA4/HLA-DRB1/NRXN2/VSIR/ICOS/HLA-DQB1/NLGN4X/HLA-E/HLA-DMA/GLG1/CD6/CDH2/ITGAM/CD8A/NCAM2/ITGA9/ICAM1/CD4/ITGAV/NRXN3/NEGR1	6.15011620866618
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	50/1078	203/9376	2.14226308526097	COL1A1/IGF1/COL6A1/COL6A3/PDGFRA/COL6A2/FN1/LAMA2/PDGFRB/AKT3/PRKCA/CCND2/LAMB1/COL4A1/PIP5K1B/MYL9/COL4A2/FLNA/RAC2/HGF/TNXB/BIRC3/THBS2/FYN/PARVG/COL4A6/EMP1/ITGA1/COL4A5/COL1A2/LAMC3/PRKCB/PPP1CB/PIK3R1/PIK3CD/ITGA5/ITGA4/TNC/VAV3/CTNNB1/RAC3/PAK3/ACTN1/EMP2/ITGA9/MYLK3/PDGFD/ACTB/ITGAV/PARVA	5.93016486547505
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	46/1078	180/9376	2.22271696557411	B2M/HLA-DRA/HLA-A/BST2/CD74/AKT3/TAP1/HLA-C/OAS2/STAT1/HLA-DRB5/TAP2/HLA-F/BIRC3/HLA-DPA1/HLA-B/FASLG/HLA-DPB1/IRF9/CCL5/HLA-DQA2/HLA-DQA1/TNF/PPP1CB/PIK3R1/PDIA3/PIK3CD/IL1B/IFNAR2/IFNG/ITGA5/HLA-DRB1/OAS3/CCL2/HLA-DQB1/HLA-E/HLA-DMA/SOCS3/IRF3/BID/CALR/IKBKG/FAS/TAPBP/OAS1/BAX	5.96995438566321
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	55/1078	233/9376	2.0530787422265	COL3A1/COL1A1/COL6A1/COL6A3/VIM/NID1/DCN/COL6A2/FN1/LAMA2/ELN/COL5A2/COL5A1/FBN1/COL4A1/FBLN2/MYL9/FMNL1/CSRP2/TPM2/COL4A2/FBLN1/SYNE1/SPTBN1/THBS2/VCAN/COL4A6/SSPN/LMOD1/LMNB1/TRIM55/TNNC1/TTN/ITGA1/COL4A5/COL1A2/FMN2/FHL1/PDLIM2/DMD/COL5A3/ITGA5/ITGA4/PDLIM4/SNTB1/SYNE3/FMNL3/ATP1B1/SYNPO2/ITGA9/ACTB/ANK3/TNNC2/ITGAV/ANKRD23	5.86681981407171
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	50/1078	204/9376	2.13176179562734	COL1A1/IGF1/HPSE2/DCN/FN1/TIMP3/TWIST2/AKT3/PRKCA/ITPR2/MMP2/LUM/FLNA/HOXD10/WNT4/CTSL/FGF2/HGF/PLCG2/CD63/ERBB4/TGFB1/WNT5A/MYC/FASLG/COL1A2/PRKCB/TNF/PPP1CB/PIK3R1/PIK3CD/DDX5/ITGA5/PLAU/MSN/VAV3/WNT2/CTNNB1/MAPK12/SMO/ESR1/HCLS1/MDM2/PTCH1/ITPR3/FZD2/ACTB/FAS/ANK3/ITGAV	5.89042178459559
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	70/1078	333/9376	1.82832182832183	COL1A1/COL6A1/COL6A3/HLA-A/COL6A2/FN1/LAMA2/PDGFRB/AKT3/MX1/HLA-C/CCND2/LAMB1/COL4A1/STAT1/COL4A2/ISG15/MX2/CDK6/OASL/WNT4/HLA-F/TNXB/THBS2/JAG1/PTGER4/WNT5A/COL4A6/HLA-B/FASLG/PPP2R2B/IRF9/ITGA1/COL4A5/COL1A2/LAMC3/ATP6V0B/TNF/PIK3R1/PIK3CD/CREB3L2/IFNAR2/ITGA5/ITGA4/IRF1/PARD6G/TNC/E2F1/HLA-E/WNT2/CTNNB1/MFNG/IRF3/MDM2/BCAP31/ITGA9/ATM/TCF7/FZD2/MAML2/CRB3/IKBKG/PPP2R5D/FAS/MAML3/LFNG/ITGAV/HES6/BAX/TCF7L2	5.54719280424811
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	28/1078	88/9376	2.76741440377804	C1R/C1S/CFD/SERPING1/TFPI/ITGB2/C1QA/C1QB/F10/MASP1/SERPINE2/C1QC/PLAT/PROCR/ITGAX/C6/SERPINE1/F2R/BDKRB2/PROS1/PLAU/SERPINA5/CFI/ITGAM/CR1L/C5AR1/CLU/SERPINA1	6.00380980982524
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	30/1078	103/9376	2.53327809499793	AKT3/CCL3/C1QA/FOS/C1QB/CD247/ADCY1/TGFB1/CXCL8/FASLG/C1QC/PPP2R2B/CCL5/TNF/PIK3R1/SERPINE1/PIK3CD/IL1B/IFNG/GNAI2/CD3E/BDKRB2/CCL3L1/CCL2/GNAQ/PLCB4/MAPK12/CALR/IKBKG/FAS	5.63946255102974
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	25/1078	78/9376	2.78768850197422	HLA-DRA/STAT1/ITGB2/FOS/HLA-DRB5/HLA-DPA1/TGFB1/HLA-DPB1/HLA-DQA2/PRKCB/HLA-DQA1/TNF/MARCKSL1/IL1B/IFNG/NCF1/ITGA4/HLA-DRB1/FCGR3A/HLA-DQB1/HLA-DMA/MAPK12/ITGAM/CR1L/CYBA	5.71416373583996
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	36/1078	142/9376	2.20502234184327	AKT3/ITPR2/STAT1/PPP3CA/TYROBP/FOS/LCP2/PLCG2/TGFB1/FYN/CAMK4/LCK/IRF9/ATP2A3/ACP5/FOSB/TNF/PIK3R1/NFATC2/PIK3CD/IL1B/IFNAR2/IFNG/NCF1/TEC1/MITF/FCGR3A/MAPK12/CSF1/SOCS3/ITPR3/JUNB/IKBKG/IL1R1/CYBA/SIRPA	5.21497990790211
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	71/1078	362/9376	1.70588054408102	COL1A1/IGF1/COL6A1/COL6A3/PDGFRA/COL6A2/FN1/LAMA2/PDGFRB/AKT3/PRKCA/CCND2/MAGI2/LAMB1/COL4A1/IL2RB/FGF10/GNG2/COL4A2/CDK6/IL2RG/FGF2/HGF/TNXB/ERBB4/THBS2/PIK3AP1/MYC/COL4A6/FASLG/HSP90B1/PPP2R2B/PIK3CG/HSP90AA1/ITGA1/COL4A5/PRLR/COL1A2/LAMC3/PIK3R1/PIK3CD/PIK3R5/CREB3L2/IFNAR2/IL7/ITGA5/ITGA4/GHR/F2R/PIK3R6/MYB/TNC/AREG/FGF7/GNGT2/GNG11/CSF1/MDM2/FLT3LG/ANGPT1/ITGA9/PDGFD/GNB2/BRCA1/JAK3/HSP90AB1/IKBKG/PPP2R5D/GNGT1/ITGAV/EREG	4.93668053161053
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	38/1078	155/9376	2.13231192770363	HLA-DRA/HLA-A/C1R/TAP1/HLA-C/ITGB2/MRC2/HLA-DRB5/CORO1A/TAP2/CTSL/HLA-F/TUBB6/HLA-DPA1/THBS2/HLA-B/HLA-DPB1/DYNC2H1/CD14/HLA-DQA2/HLA-DQA1/ATP6V0B/CTSS/ITGA5/NCF1/HLA-DRB1/RAB7B/FCGR3A/HLA-DQB1/HLA-E/HLA-DMA/ITGAM/CALR/ACTB/CYBA/COLEC11/ITGAV/RAB5B	5.12331694559072
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	41/1078	173/9376	2.06127811082394	HLA-DRA/AKT3/PRKCA/MX1/OAS2/STAT1/MX2/CDK6/HLA-DRB5/HLA-DPA1/CXCL8/FASLG/RSAD2/HLA-DPB1/IRF9/CCL5/HLA-DQA2/PRKCB/HLA-DQA1/TNF/PIK3R1/PIK3CD/IL1B/IFNAR2/IFNG/PYCARD/HLA-DRB1/OAS3/CCL2/HLA-DQB1/HLA-DMA/SOCS3/IRF3/BID/ACTB/ADAR/ICAM1/IKBKG/FAS/OAS1/BAX	5.07803688142374
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	19/1078	54/9376	3.06026248883392	HLA-DRA/HLA-A/GZMB/HLA-C/HLA-DRB5/HLA-F/PRF1/HLA-DPA1/HLA-B/FASLG/HLA-DPB1/HLA-DQA2/HLA-DQA1/HLA-DRB1/HLA-DQB1/HLA-E/HLA-DMA/FAS/TG	5.47234147248827
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	28/1078	101/9376	2.41121254982641	COL3A1/COL1A1/FN1/AKT3/PRKCA/MMP2/COL4A1/STAT1/COL4A2/PLCG2/TGFB1/CXCL8/COL4A6/PIM1/COL4A5/COL1A2/PRKCB/TNF/PIK3R1/SERPINE1/PIK3CD/IL1B/EGR1/CCL2/PLCB4/MAPK12/ICAM1/BAX	5.13930581366284
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	30/1078	115/9376	2.26893603291119	AKT3/ADCY3/PRKCA/CACNA1D/ITPR2/GNG2/FOS/ADCY1/FYN/CACNA1C/KCNQ5/CAMK4/PIK3CG/PRKCB/PIK3R1/PIK3CD/PIK3R5/CREB3L2/GNAI2/KCNJ2/PIK3R6/ADCY5/GNGT2/GNAQ/PLCB4/GNG11/KCNQ3/ITPR3/GNB2/GNGT1	4.93478244730809
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	37/1078	157/9376	2.04975006794843	HLA-A/AKT3/HLA-C/CCND2/CACNA1D/ITPR2/CDKN2A/PPP3CA/CDK6/HLA-F/ETS1/RASSF5/MYBL2/TGFB1/MYC/CXCL8/HLA-B/KIR2DL4/CALML4/GADD45A/PPP1CB/PIK3R1/NFATC2/SERPINE1/PIK3CD/E2F1/HLA-E/MAPK12/CDK1/CHEK1/HIPK1/NFATC4/FBXW11/MDM2/CALM3/ATM/ITPR3	4.78081714769082
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	31/1078	122/9376	2.21004288451595	AKT3/PTPRC/PPP3CA/FOS/CD247/LCP2/ITK/FYN/LCK/PPP2R2B/TNF/PIK3R1/NFATC2/ZAP70/PIK3CD/IFNG/TEC1/CSF2/CD3E/ICOS/VAV3/PAK3/MAPK12/RASGRP1/CARD11/CD8A/IKBKG/PPP2R5D/GRAP2/CD4/PRKCQ	4.84868793299252
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	17/1078	50/9376	2.95717996289425	GYPC/ITGB2/KLRB1/LRP1/KLRK1/HGF/THBS2/TGFB1/CXCL8/HBB/ITGAL/TNF/IL1B/IFNG/CCL2/CR1L/ICAM1	5.0012246251727
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	24/1078	86/9376	2.42723389567243	LAMA2/CACNA2D1/CACNA1D/SLC8A1/CTNNA3/LEF1/GJA1/CACNA1C/SSPN/RYR2/ITGA1/CACNB2/ATP2A3/DMD/ITGA5/ITGA4/SNTB1/CTNNB1/CDH2/ITGA9/TCF7/ACTB/ITGAV/TCF7L2	4.79230911528965
Organismal Systems	Immune system	hsa04611	Platelet activation	31/1078	126/9376	2.13988279294402	COL3A1/COL1A1/PRKG1/AKT3/ADCY3/FCER1G/ITPR2/APBB1IP/LCP2/ADCY1/PLCG2/FYN/PIK3CG/COL1A2/PPP1CB/PIK3R1/PIK3CD/PIK3R5/GNAI2/F2R/PIK3R6/ADCY5/STIM1/GP1BB/GNAQ/PLCB4/MAPK12/RASGRP1/MYLK3/ITPR3/ACTB	4.64283134054396
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	45/1078	212/9376	1.84618615885462	IGF1/PDGFRA/PDGFRB/AKT3/ADCY3/PRKCA/MAGI2/FGF10/APBB1IP/ITGB2/RAC2/LCP2/ADCY1/FGF2/FYB1/HGF/RASSF5/PFN2/ITGAL/CALML4/PRKCB/PIK3R1/PIK3CD/EVL/GNAI2/F2R/ADCY5/PARD6G/DOCK4/FGF7/VAV3/CTNNB1/PRKD3/RAC3/GNAQ/PLCB4/MAPK12/CSF1/ITGAM/ANGPT1/CALM3/SKAP1/RAPGEF2/PDGFD/ACTB	4.49158487629361
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	20/1078	66/9376	2.6356327655029	HLA-DRA/RORA/STAT1/HLA-DRB5/IL2RG/IL21R/HLA-DPA1/MAF/TGFB1/HLA-DPB1/GATA3/STAT4/HLA-DQA2/HLA-DQA1/TNF/IL1B/IFNG/HLA-DRB1/HLA-DQB1/HLA-DMA	4.80608262204958
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	29/1078	116/9376	2.17439703153989	PRKCA/MMP2/MYL9/ITGB2/RAC2/CTNNA3/ITK/PLCG2/RASSF5/RHOH/JAM3/ITGAL/PRKCB/PIK3R1/PIK3CD/GNAI2/NCF1/ITGA4/THY1/MSN/VAV3/CTNNB1/MAPK12/ACTN1/ITGAM/CXCL12/ACTB/ICAM1/CYBA	4.58719021793786
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	27/1078	105/9376	2.23652266101246	CCL4/TNFAIP3/BIRC3/PLCG2/CXCL8/BCL2A1/LCK/CXCL3/GADD45A/CD14/PRKCB/TNF/ZAP70/IL1B/TRAF1/LTB/PLAU/CARD11/LTBR/CXCL12/ATM/CCL4L2/ICAM1/IKBKG/IL1R1/CXCL2/PRKCQ	4.59242150761555
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	33/1078	140/9376	2.05014577259475	AKT3/ADCY3/ITPR2/SLC8A1/GNG2/ADCY1/JAG1/CAMK4/RYR2/PLAT/CALML4/PIK3CG/SERPINE1/PIK3R5/GNAI2/EGR1/PIK3R6/ADCY5/ACTA2/PDE3B/GNGT2/GNAQ/PLCB4/GNG11/PRKAG2/CALM3/MYLK3/ITPR3/MEF2C/GNB2/HDAC4/GNGT1/KLF2	4.51211279308511
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	26/1078	100/9376	2.26137291280148	CCL4/CCL3/XCL1/IL2RB/XCL2/IL2RG/CXCR3/CXCL8/CXCL13/TNFRSF1B/CCL5/CXCL3/TNF/IL10RA/CCL3L1/CCL2/CSF1/LTBR/CXCL12/CCL4L2/IL20RB/CXCL2/CCL20/ACKR4/CCL15/ACKR3	4.57058125279568
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	22/1078	78/9376	2.45316588173731	C1R/C1S/SERPING1/ITGB2/C1QA/FOS/C1QB/CXCL8/C1QC/CALML4/CD14/TNF/IL1B/GNAI2/PYCARD/ITGA5/IRF1/IRF8/MAPK12/ITGAM/IRF3/CALM3	4.64489634207146
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	35/1078	154/9376	1.97672457412717	CACNA2D1/ADCY3/PRKCA/CACNA1D/ITPR2/MYL9/PPP3CA/FOS/ADCY1/CACNA1C/CAMK4/RYR2/CAMK1/CALML4/PIK3CG/CACNB2/PRKCB/CD38/PPP1CB/NFATC2/PIK3R5/GNAI2/KCNJ2/PIK3R6/ADCY5/GNAQ/PLCB4/PRKAG2/RGS2/NFATC4/CALM3/MYLK3/ITPR3/MEF2C/ACTB	4.40482054246292
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	29/1078	119/9376	2.11958029965233	AKT3/IL15/FOS/TNFAIP3/BIRC3/JAG1/TNFRSF1B/CCL5/CXCL3/TNF/PIK3R1/PIK3CD/CREB3L2/IL1B/TRAF1/CSF2/IRF1/CCL2/MAPK12/CSF1/SOCS3/MMP14/JUNB/ICAM1/IKBKG/FAS/CXCL2/CCL20/FRMD8	4.42998137320247
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	32/1078	138/9376	2.01683202925439	FN1/AKT3/PIP5K1B/WIPF1/RAC2/FOS/LCP2/FYB1/CXCL8/LCK/TNF/PIK3R1/WIPF3/NFATC2/ZAP70/PIK3CD/IL1B/PYCARD/ITGA5/ITGA4/CCL2/VAV3/WAS/RAC3/GNAQ/MAPK12/ELMO1/IRF3/CD8A/ACTB/IKBKG/CD4	4.33718637958819
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	26/1078	103/9376	2.19550768233154	COL3A1/COL1A1/COL6A1/MME/COL6A3/COL6A2/ELN/COL5A2/COL5A1/COL15A1/COL4A1/SLC8A1/COL4A2/SLC1A5/COL4A6/COL23A1/COL4A5/COL1A2/COL5A3/COL21A1/COL7A1/SLC36A4/ATP1B1/DPP4/COL10A1/SLC7A7	4.39712849611028
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	42/1078	201/9376	1.81740647412289	IGF1/ZEB1/HOXA10/RUNX1T1/GZMB/WT1/CCND2/IL2RB/HOXA11/BIRC3/MAF/MYC/CXCL8/EYA1/FLI1/HOXA9/BCL2A1/PLAT/PBX3/GADD45A/CD14/BCL11B/DDX5/TRAF1/CSF2/ARNT2/MITF/PLAU/GRIA3/JMJD1C/MEIS1/CDK14/CDKN2C/ITGAM/ZBTB16/KDM6A/MDM2/ATM/MEF2C/ETV5/PROM1/BAX	4.22222495985824
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	31/1078	133/9376	2.02725738278907	AKT3/PRKCA/CACNA1D/ITPR2/GNG2/PPP3CA/FOS/ARRB1/CACNA1C/PPP2R2B/GRIA1/CALML4/PRKCB/SCN1A/PPP1CB/CREB3L2/GNAI2/MAOB/KIF5C/ADCY5/GNGT2/GRIA3/GNAQ/PLCB4/MAPK12/GNG11/CALM3/ITPR3/GNB2/PPP2R5D/GNGT1	4.30038084286717
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	16/1078	50/9376	2.78322820037106	HLA-DRA/IL15/HLA-DRB5/HLA-DPA1/TGFB1/HLA-DPB1/HLA-DQA2/HLA-DQA1/ITGA4/HLA-DRB1/PIGR/ICOS/HLA-DQB1/HLA-DMA/LTBR/CXCL12	4.55672189429624
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	26/1078	105/9376	2.15368848838237	IGF1/LAMA2/CACNA2D1/ADCY3/CACNA1D/SLC8A1/TPM2/ADCY1/TGFB1/CACNA1C/SSPN/TNNC1/RYR2/TTN/ITGA1/CACNB2/ATP2A3/TNF/DMD/ITGA5/ITGA4/ADCY5/SNTB1/ITGA9/ACTB/ITGAV	4.28477697513242
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	32/1078	142/9376	1.96001985941624	AKT3/MMP2/RAC2/FOS/CTSL/DUSP1/HSP90B1/PLAT/CALML4/HSP90AA1/GSTA3/TNF/PIK3R1/PIK3CD/IL1B/IFNG/NCF1/CCL2/CTNNB1/RAC3/MAPK12/NQO1/CALM3/MEF2C/ACTB/HSP90AB1/ICAM1/IKBKG/IL1R1/CYBA/ITGAV/KLF2	4.15468170522423
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	24/1078	97/9376	2.15198056729721	PRKG1/ADCY3/PRKCA/CACNA1D/GNG2/FOS/ADCY1/CACNA1C/CACNA1G/RYR2/GRIA1/CALML4/PRKCB/GNAI2/ADCY5/GNGT2/GRIA3/GNAQ/PLCB4/GNG11/CALM3/ITPR3/GNB2/GNGT1	4.1104440036081
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	13/1078	38/9376	2.9754906747388	TAP1/PTPRC/TAP2/IL2RG/LCK/ZAP70/CD3E/ICOS/ADA/CD8A/JAK3/IKBKG/CD4	4.39792836188923
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	20/1078	75/9376	2.31935683364255	IGF1/CCND2/CDKN2A/CDK6/TP73/RRM2/RPRM/GADD45A/SERPINE1/TP53AIP1/CDK1/CHEK1/BID/MDM2/ZNF385A/ATM/STEAP3/FAS/BAX/GORAB	4.13462745118687
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	35/1078	166/9376	1.83382882178063	EDNRA/PRKG1/AKT3/ADCY3/CACNA1D/ITPR2/SLC8A1/MYL9/ADRA2C/PPP3CA/ADCY1/CACNA1C/CALML4/PIK3CG/ATP2A3/PPP1CB/NFATC2/PIK3R5/CREB3L2/GNAI2/PIK3R6/ADCY5/BDKRB2/PDE3B/KCNMB2/GNAQ/PLCB4/KCNMB4/ATP1B1/RGS2/NFATC4/CALM3/MYLK3/ITPR3/MEF2C	3.90669435497846
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	24/1078	99/9376	2.10850621240232	IGF1/ADCY3/PRKCA/ITPR2/ADCY1/PLCG2/PTGER4/PTGER2/CALML4/PRKCB/PPP1CB/PIK3R1/PIK3CD/IL1B/ADCY5/BDKRB2/TRPV2/GNAQ/PLCB4/MAPK12/CALM3/ITPR3/IL1R1/PRKCQ	3.99631997473795
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	24/1078	99/9376	2.10850621240232	HLA-DRA/C1R/C1S/CFD/ITGB2/C1QA/C1QB/HLA-DRB5/MASP1/HLA-DPA1/C1QC/HLA-DPB1/ITGAL/HLA-DQA2/HLA-DQA1/SELPLG/HLA-DRB1/FCGR3A/HLA-DQB1/HLA-DMA/CFI/ITGAM/C5AR1/ICAM1	3.99631997473795
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	24/1078	99/9376	2.10850621240232	IGF1/LAMA2/CACNA2D1/CACNA1D/SLC8A1/TPM2/TGFB1/CACNA1C/SSPN/TNNC1/RYR2/TTN/ITGA1/CACNB2/ATP2A3/TNF/DMD/ITGA5/ITGA4/SNTB1/PRKAG2/ITGA9/ACTB/ITGAV	3.99631997473795
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	9/1078	21/9376	3.72753776835409	CHSY3/XYLT1/CHST11/UST/CHST12/CHST7/DSEL/DSE/CSGALNACT1	4.50989912402871
Human Diseases	Infectious disease: viral	hsa05162	Measles	30/1078	136/9376	1.91858561606461	AKT3/MX1/CCND2/OAS2/IL2RB/STAT1/FOS/MX2/TNFAIP3/CDK6/IL2RG/TP73/FASLG/IRF9/PIK3R1/PIK3CD/IL1B/IFNAR2/CD3E/HSPA1A/OAS3/MSN/IRF3/BID/JAK3/ADAR/IKBKG/FAS/OAS1/BAX	3.88921016852321
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	26/1078	112/9376	2.01908295785847	HLA-DRA/LAMA2/AKT3/LAMB1/STAT1/HLA-DRB5/BIRC3/HLA-DPA1/TGFB1/HLA-DPB1/PIK3CG/HLA-DQA2/LAMC3/HLA-DQA1/TNF/IL10RA/PIK3R5/IFNG/GNAI2/HLA-DRB1/PIK3R6/HSPA1A/HLA-DQB1/HLA-DMA/MAPK12/IKBKG	3.91045759228257
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	25/1078	106/9376	2.05131795428291	IGF1/ZEB1/PDGFRA/PDGFRB/AKT3/LEF1/AR/HSP90B1/PLAT/HSP90AA1/PIK3R1/PIK3CD/CREB3L2/PLAU/E2F1/CTNNB1/GRM5/MDM2/TCF7/SLC46A1/PDGFD/HSP90AB1/ETV5/IKBKG/TCF7L2	3.92333552061524
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	22/1078	89/9376	2.14996560421922	COL1A1/COL6A1/COL6A3/COL6A2/FN1/LAMA2/LAMB1/COL4A1/COL4A2/TNXB/THBS2/COL4A6/ITGA1/COL4A5/COL1A2/LAMC3/ITGA5/ITGA4/TNC/GP1BB/ITGA9/ITGAV	3.92871418217801
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	26/1078	115/9376	1.96641122852303	ADCY3/PRKCA/ITPR2/MMP16/FOS/PDE4B/ADCY1/ARRB1/AKAP13/GATA3/PTH1R/PRKCB/CREB3L2/GNAI2/EGR1/NR4A2/ADCY5/PDE4A/GNAQ/PLCB4/WNK1/PDE4D/MMP14/WNK4/ITPR3/MEF2C	3.75828965661555
Human Diseases	Substance dependence	hsa05032	Morphine addiction	22/1078	91/9376	2.10271361291769	ADCY3/PRKCA/GNG2/PDE4B/ADCY1/ARRB1/GRK3/GABBR1/PRKCB/GABRA2/GNAI2/PDE7A/ADCY5/PDE4A/PDE3B/GNGT2/GRK5/GNG11/PDE8B/PDE4D/GNB2/GNGT1	3.80978775354862
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	26/1078	116/9376	1.94945940758749	ADCY3/PRKCA/CACNA1D/ITPR2/GNG2/PPP3CA/ADCY1/CACNA1C/GRK3/GRIA1/PRKCB/GRM7/GNAI2/ADCY5/GNGT2/GRIA3/GNAQ/GRIN3B/PLCB4/GNG11/GRM5/TRPC1/ITPR3/GNB2/GNGT1/GRIK2	3.70858473739804
Human Diseases	Immune disease	hsa05310	Asthma	11/1078	32/9376	2.98979591836735	HLA-DRA/FCER1G/HLA-DRB5/HLA-DPA1/HLA-DPB1/HLA-DQA2/HLA-DQA1/TNF/HLA-DRB1/HLA-DQB1/HLA-DMA	4.06373531700867
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	47/1078	254/9376	1.60939622806889	PDGFRA/EDNRA/PDGFRB/ADCY3/PRKCA/CACNA1D/ITPR2/NTRK3/FGF10/SLC8A1/PPP3CA/ADCY1/FGF2/HGF/PLCG2/ERBB4/CACNA1C/CACNA1G/TNNC1/CAMK4/RYR2/CAMK1/CALML4/ATP2A3/PRKCB/CD38/NFATC2/F2R/MRLN/BDKRB2/STIM1/MCOLN2/FGF7/STIM2/GNAQ/GRIN3B/PLCB4/GRM5/NFATC4/CALM3/MYLK3/ITPR3/PDGFD/P2RX4/AVPR1A/TNNC2/MCOLN3	3.54878664012569
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	36/1078	181/9376	1.72990703061737	HLA-DRA/CD74/AKT3/FCER1G/STAT1/ITGB2/PPP3CA/MRC2/LSP1/HLA-DRB5/CORO1A/HLA-DPA1/TGFB1/HLA-DPB1/ITGAX/CALML4/CD14/HLA-DQA2/HLA-DQA1/ATP6V0B/TNF/CTSS/IL10RA/IL1B/IFNG/HLA-DRB1/FCGR3A/HLA-DQB1/HLA-DMA/MAPK12/ITGAM/CR1L/BID/CALM3/BAX/RAB5B	3.57387427895239
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	28/1078	130/9376	1.87332667332667	COL3A1/COL1A1/AKT3/ADCY3/PRKCA/MMP2/COL4A1/GNG2/COL4A2/FOS/ADCY1/ARRB1/TGFB1/COL4A6/COL4A5/COL1A2/PIK3R1/PIK3CD/CREB3L2/GNAI2/ADCY5/ACTA2/GNGT2/PLCB4/MAPK12/GNG11/GNB2/GNGT1	3.61393019483675
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	53/1078	298/9376	1.54688647881361	CCL4/CCL3/GDF7/XCL1/IL2RB/XCL2/IL15/TNFRSF18/IL2RG/RELL1/IL21R/TGFB1/CXCR3/CXCL8/IL32/IL27RA/CXCL13/FASLG/TNFRSF1B/CCL5/GDF11/PRLR/CXCL3/IL16/TNF/IL10RA/BMP8A/IL1B/IFNAR2/IFNG/IL7/CSF2/GHR/LTB/IL5RA/CCL3L1/CCL2/TNFRSF19/CSF1/ACVRL1/LTBR/CXCL12/CCL4L2/IL20RB/IL1R1/CD4/FAS/CXCL2/IL17RA/CCL20/ACKR4/CCL15/ACKR3	3.45794859005697
Human Diseases	Cancer: specific types	hsa05214	Glioma	19/1078	76/9376	2.17439703153989	IGF1/PDGFRA/PDGFRB/AKT3/PRKCA/CDKN2A/CDK6/PLCG2/CAMK4/CAMK1/CALML4/GADD45A/PRKCB/PIK3R1/PIK3CD/E2F1/MDM2/CALM3/BAX	3.70500305205796
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	17/1078	65/9376	2.27475381761096	AKT3/PRKCA/CACNA1D/ITPR2/TRPC4/ARRB1/CACNA1C/CACNA1G/GABBR1/KCNN3/PRKCB/PIK3R1/PIK3CD/GNAQ/PLCB4/TRPC1/ITPR3	3.71700495155408
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	35/1078	178/9376	1.7101999124471	APCDD1/SFRP4/PRKCA/MCC/CCND2/DKK1/PPP3CA/RAC2/SERPINF1/ROR1/WNT4/LEF1/SFRP1/PRICKLE1/TLE4/WNT5A/MYC/PRICKLE2/ROR2/PRKCB/NFATC2/TBL1X/CXXC4/WNT2/CTNNB1/NLK/RAC3/PLCB4/NFATC4/FBXW11/CTNNBIP1/TCF7/FZD2/CCDC88C/TCF7L2	3.44788058834463
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	28/1078	134/9376	1.81740647412289	CALCRL/EDNRA/RAMP1/PRKG1/ADCY3/PRKCA/CACNA1D/ITPR2/MYL9/ADCY1/CALD1/CACNA1C/CALML4/PRKCB/PPP1CB/ADCY5/ACTA2/RAMP2/KCNMB2/GNAQ/PLCB4/KCNMB4/CALM3/MYLK3/ITPR3/AVPR1A/PLA2G2A/PRKCQ	3.4349134109083
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	36/1078	187/9376	1.67440199220184	OAS2/ITPR2/GBP1/STAT1/TNFAIP3/BIRC3/CXCL8/GPSM3/GBP5/IRF9/GBP4/CCL5/HSP90AA1/CXCL3/NLRP1/TNF/PSTPIP1/IL1B/IFNAR2/PYCARD/ANTXR2/OAS3/CCL2/TRPV2/PLCB4/MAPK12/IRF3/ATG12/IFI16/ITPR3/HSP90AB1/IKBKG/CYBA/CXCL2/OAS1/GBP2	3.35748302353599
Human Diseases	Cancer: specific types	hsa05218	Melanoma	18/1078	73/9376	2.14461077083386	IGF1/PDGFRA/PDGFRB/AKT3/FGF10/CDKN2A/CDK6/FGF2/HGF/GADD45A/PIK3R1/PIK3CD/MITF/FGF7/E2F1/MDM2/PDGFD/BAX	3.53847434576049
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	28/1078	137/9376	1.77760925206181	AKT3/GZMB/ITPR2/CTSW/CTSC/PTPN13/FOS/CTSL/BIRC3/PRF1/LMNB1/BCL2A1/FASLG/GADD45A/TNF/CTSS/PIK3R1/PIK3CD/TRAF1/TP53AIP1/BID/ATM/ITPR3/ACTB/IKBKG/FAS/BAX/DFFA	3.30458953062161
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	17/1078	69/9376	2.14288403108279	PRKCA/CACNA1D/PPP3CA/FOS/CACNA1C/CAMK4/GRIA1/CALML4/FOSB/PRKCB/PPP1CB/CREB3L2/MAOB/ADCY5/GRIA3/GRIN3B/CALM3	3.43423615737378
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	21/1078	93/9376	1.96397151235861	FN1/LAMA2/AKT3/LAMB1/COL4A1/COL4A2/CDK6/BIRC3/MYC/COL4A6/COL4A5/GADD45A/LAMC3/PIK3R1/PIK3CD/TRAF1/E2F1/RARB/IKBKG/ITGAV/BAX	3.36720689538058
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	29/1078	144/9376	1.75159760874047	AKT3/C1QA/C1QB/LEF1/CXCL8/FASLG/C1QC/SCD5/CXCL3/CD14/TNF/IL1B/FASN/CTNNB1/MAPK12/ACADVL/TRA2A/PRKAG2/IRF3/C5AR1/ADH4/TCF7/ADH6/IKBKG/FAS/CXCL2/IL17RA/SREBF1/TCF7L2	3.27587288424447
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	35/1078	184/9376	1.65443252399774	SLIT3/NRP1/PRKCA/GDF7/ROBO1/MYL9/PPP3CA/TRPC4/EPHA6/RAC2/ABLIM1/WNT4/PLXNC1/PLCG2/FYN/WNT5A/UNC5C/SEMA5A/SRGAP3/PIK3R1/NFATC2/PIK3CD/GNAI2/PARD6G/RAC3/PAK3/SEMA6D/SMO/RGS3/NFATC4/TRPC1/CXCL12/PLXNA4/PTCH1/ROBO2	3.23129852091086
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	11/1078	37/9376	2.5857694429123	PRKCA/HBB/FASLG/PRKCB/TNF/IL1B/IFNG/GNAQ/PLCB4/ICAM1/FAS	3.48336531120644
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	30/1078	154/9376	1.69433534925186	AKT3/CACNA2D1/ADCY3/PRKCA/CACNA1D/SLC8A1/TPM2/ADCY1/CACNA1C/TNNC1/RYR2/PPP2R2B/CALML4/PIK3CG/CACNB2/ATP2A3/PPP1CB/PIK3R5/CREB3L2/GNAI2/PIK3R6/ADCY5/GNAQ/PLCB4/MAPK12/KCNE1/ATP1B1/POPDC3/CALM3/PPP2R5D	3.1313050687558
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	21/1078	98/9376	1.86376888417705	ADCY3/PRKCA/CACNA1D/ITPR2/ADCY1/CACNA1C/CACNA1G/CAMK4/CAMK1/CALML4/PRKCB/CREB3L2/NR4A2/ADCY5/PRKD3/GNAQ/PLCB4/ATP1B1/DAGLA/CALM3/ITPR3	3.09807346766528
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	30/1078	157/9376	1.66195951455278	AXL/LRP1/C1QA/MEGF10/C1QB/SLC16A1/PTGER4/TGFB1/MFGE8/C1QC/PTGER2/ATP8A2/ATP2A3/ANO4/NFATC2/PROS1/RAB7B/ANO6/LIPA/MAPK12/ELMO1/NFATC4/CALR/VPS8/SIRPA/ABCA1/ITGAV/GPR132/RAB5B/TYRO3	3.01472464244365
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	22/1078	105/9376	1.822351797862	AKT3/FCER1G/ITPR2/STAT1/PPP3CA/LSP1/PLCG2/IRF9/CALML4/TNF/PIK3R1/NFATC2/PIK3CD/IL1B/PYCARD/IRF1/MAPK12/NFATC4/MDM2/CALM3/ITPR3/IKBKG	3.05419884519991
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	17/1078	75/9376	1.97145330859617	ADCY3/PRKCA/ITPR2/ADCY1/HSPA5/HSP90B1/PRKCB/CREB3L2/GPX8/ADCY5/GNAQ/PDIA4/PLCB4/ATP1B1/ITPR3/DUOX1/TG	3.04436026315852
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	16/1078	69/9376	2.01683202925439	AKT3/PRKCA/FCER1G/ALOX5AP/RAC2/LCP2/PLCG2/FYN/INPP5D/TNF/PIK3R1/PIK3CD/CSF2/VAV3/RAC3/MAPK12	3.0554642692249
Organismal Systems	Endocrine system	hsa04924	Renin secretion	16/1078	69/9376	2.01683202925439	EDNRA/CACNA1D/ITPR2/PPP3CA/PTGER4/CACNA1C/PTGER2/CALML4/GNAI2/KCNJ2/ADCY5/PDE3B/GNAQ/PLCB4/CALM3/ITPR3	3.0554642692249
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	38/1078	216/9376	1.53013124441696	AKT3/PRKCA/CCL3/PPP3CA/FOS/CXCL8/HSPA5/FASLG/HSP90B1/CCL5/CALML4/HSP90AA1/CXCL3/CD14/TNF/PIK3R1/NFATC2/PIK3CD/IL1B/PYCARD/NCF1/CCL3L1/HSPA1A/CCL2/VAV3/PLCB4/MAPK12/IRF3/BID/CALM3/HSP90AB1/ICAM1/IKBKG/CYBA/FAS/CXCL2/ABCA1/BAX	2.84099744516726
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	9/1078	30/9376	2.60927643784787	TYMS/ABCC4/TNF/ABCG2/IL1B/DHFR/SLC46A1/GGH/IKBKG	3.1819012337959
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	28/1078	148/9376	1.64548964548965	IGF1/AKT3/FGF10/PGR/FOS/CDK6/WNT4/LEF1/FGF2/JAG1/WNT5A/MYC/GADD45A/PIK3R1/PIK3CD/BRCA2/NCOA1/FGF7/E2F1/WNT2/CTNNB1/ESR1/TCF7/FZD2/BRCA1/JAG2/BAX/TCF7L2	2.85282182378175
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	40/1078	232/9376	1.49958415968268	PDGFRA/FN1/PDGFRB/AKT3/FGF10/PIP5K1B/MYL9/ITGB2/RAC2/FGF2/NCKAP1L/PFN2/ITGAL/ITGAX/ITGA1/PPP1CB/PIK3R1/C6/PIK3CD/ITGA5/ITGA4/F2R/BDKRB2/FGF7/MSN/VAV3/CYFIP2/RAC3/PAK3/ACTN1/ITGAM/ABI2/CXCL12/ITGA9/MYLK3/PDGFD/ACTB/ARHGEF6/ITGAV/FGD3	2.77710849463776
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	24/1078	122/9376	1.71100094285106	IGF1/AKT3/ADCY3/PRKCA/CACNA1D/ITPR2/STAT1/FOS/ADCY1/PLCG2/CACNA1C/PRKCB/PIK3R1/PIK3CD/CREB3L2/GNAI2/GHR/ADCY5/GNAQ/PLCB4/MAPK12/SOCS3/ITPR3/JUNB	2.84900786250009
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	28/1078	149/9376	1.63444609082193	PDGFRA/PDGFRB/AKT3/DGKB/ADCY3/PRKCA/FCER1G/PIP5K1B/PLPP3/AGPAT4/PLPP1/ADCY1/PLCG2/FYN/CXCL8/PIK3CG/PIK3R1/GRM7/PIK3CD/PIK3R5/F2R/DGKD/PIK3R6/ADCY5/PLCB4/GRM5/PDGFD/AVPR1A	2.81362298448316
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	39/1078	226/9376	1.50091122531072	EDNRA/AKT3/ADCY3/CACNA1D/MYL9/RAC2/FOS/PDE4B/ADCY1/CACNA1C/GABBR1/PTGER2/ABCC4/CAMK4/RYR2/GRIA1/CALML4/ATP2A3/PPP1CB/PIK3R1/PIK3CD/CREB3L2/GNAI2/FXYD1/F2R/ADCY5/PDE4A/PDE3B/GRIA3/GLI3/VAV3/RAC3/GRIN3B/ATP1B1/POPDC3/PDE4D/GIPR/CALM3/PTCH1	2.74734209287201
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	29/1078	157/9376	1.60656086406769	SNAI2/GDF7/CCND2/ITGB2/CTNNA3/WNT4/LEF1/BIRC3/TP73/TGFB1/WNT5A/MYC/WWTR1/PPP2R2B/PPP1CB/SERPINE1/BMP8A/FRMD6/PARD6G/AREG/WNT2/CTNNB1/TEAD2/FBXW11/TCF7/FZD2/ACTB/GLI2/TCF7L2	2.76242571312263
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	20/1078	98/9376	1.77501798493052	AKT3/PRKCA/PIP5K1B/PLPP3/PTPRC/RAC2/PLPP1/PLCG2/INPP5D/PRKCB/PIK3R1/PIK3CD/MARCKS/MARCKSL1/NCF1/FCGR3A/VAV3/WAS/WASF3/ASAP1	2.77975127381934
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	16/1078	73/9376	1.90632068518566	AKT3/PRKCA/CDKN2A/CDK6/HGF/PLCG2/RASSF5/GADD45A/PRKCB/PIK3R1/PIK3CD/KIF5C/E2F1/RARB/JAK3/BAX	2.80181925181883
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	15/1078	67/9376	1.94722122227453	PRKCA/ITPR2/PPP3CA/ADCY1/CACNA1C/CAMK4/GRIA1/CALML4/PRKCB/PPP1CB/GNAQ/PLCB4/GRM5/CALM3/ITPR3	2.80443649014646
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	18/1078	86/9376	1.82042542175433	ADCY3/PRKCA/CACNA1D/ADCY1/ABCC8/CACNA1C/RYR2/KCNN3/PRKCB/CREB3L2/ADCY5/KCNMB2/GNAQ/PLCB4/KCNMB4/RIMS2/ATP1B1/ITPR3	2.75479179622216
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	20/1078	99/9376	1.75708851033526	PDGFRA/PDGFRB/AKT3/DGKB/PRKCA/PIP5K1B/PLPP3/SLC22A3/RAC2/FOS/PLPP1/PRKCB/PIK3R1/PIK3CD/DGKD/CHPT1/WAS/RAC3/WASF3/PDGFD	2.72940999576403
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	30/1078	168/9376	1.55314073681421	PDGFRA/PDGFRB/AKT3/CCND2/IL2RB/STAT1/IL15/IL2RG/IL21R/MYC/IL27RA/PIM1/IRF9/STAT4/PRLR/PIK3R1/FHL1/IL10RA/PIK3CD/IFNAR2/IFNG/IL7/CSF2/GHR/IL5RA/SOCS3/JAK3/IL20RB/PTPN2/PIAS1	2.60744966120755
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	15/1078	68/9376	1.91858561606461	RUNX1T1/AKT3/LEF1/MYC/PIM1/BCL2A1/CD14/PIK3R1/PIK3CD/CSF2/ITGAM/ZBTB16/TCF7/IKBKG/TCF7L2	2.74002302960694
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	19/1078	94/9376	1.75802313188331	FOS/TNFAIP3/CXCL8/HSP90B1/HSP90AA1/CXCL3/FOSB/TNF/IL1B/IFNG/CSF2/CCL2/MAPK15/MAPK12/HSP90AB1/IKBKG/CXCL2/IL17RA/CCL20	2.66215848731352
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	20/1078	101/9376	1.72229467844744	ADCY3/PRKCA/WNT4/ADCY1/LEF1/WNT5A/CALML4/PRKCB/CREB3L2/GNAI2/ADCY5/MITF/WNT2/CTNNB1/GNAQ/PLCB4/CALM3/TCF7/FZD2/TCF7L2	2.63042816659989
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	28/1078	156/9376	1.56110556110556	AKT3/MX1/OAS2/STAT1/MX2/CDK6/IFIT1/MYC/FASLG/RSAD2/PPP2R2B/IRF9/TNF/PIK3R1/PIK3CD/IFNAR2/IFNG/OAS3/E2F1/CTNNB1/SOCS3/IRF3/BID/IKBKG/FAS/PIAS1/OAS1/BAX	2.54712181283794
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	14/1078	63/9376	1.93279736136879	WNT4/LEF1/WNT5A/GADD45A/GLI3/WNT2/CTNNB1/SMO/PTCH1/TCF7/FZD2/GLI2/BAX/TCF7L2	2.67744825029245
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	23/1078	122/9376	1.63970923689893	AKT3/PRKCA/STAT1/WNT4/PLCG2/MYC/ATP2A3/PRKCB/PIK3R1/PIK3CD/NCOA1/DIO2/MED13L/CTNNB1/PLCB4/ESR1/MED12L/ATP1B1/MDM2/SLC16A2/ACTB/PFKM/ITGAV	2.56333928100117
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	16/1078	76/9376	1.83107118445464	ADCY3/PRKCA/ITPR2/ADCY1/CALML4/PRKCB/GNAI2/KCNJ2/ADCY5/GNAQ/PLCB4/ATP1B1/CALM3/MYLK3/ITPR3/ACTB	2.62187419772722
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	18/1078	89/9376	1.75906276708845	PDGFRA/PRKG1/PDGFRB/ADCY3/PRKCA/ITPR2/ADCY1/TUBB6/GJA1/PRKCB/GNAI2/ADCY5/GNAQ/PLCB4/GRM5/CDK1/ITPR3/PDGFD	2.59324335204655
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	28/1078	158/9376	1.54134473121815	CCND2/CDKN2A/CDK6/ANAPC4/TGFB1/MYC/CDC45/GADD45A/CDT1/NDC80/ESCO2/KNL1/E2F1/PCNA/CDK1/CDKN2C/CHEK1/DDX11/PDS5B/CDC6/MDM2/SGO1/ATM/PTTG1/CDC25B/PPP2R5D/ORC6/MCM7	2.47338891006717
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	18/1078	90/9376	1.73951762523191	AKT3/STAT1/PPP3CA/FOS/CD247/LCK/PIK3R1/NFATC2/ZAP70/PIK3CD/IFNG/CD3E/MAPK12/RASGRP1/IKBKG/CD4/BATF/PRKCQ	2.54076060871169
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	12/1078	52/9376	2.00713572142144	APOE/APOC1/LRP1/PLTP/OSBPL5/CYP27A1/LIPA/STARD3NL/SOAT1/LRPAP1/NPC2/ABCA1	2.62480377941497
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	39/1078	238/9376	1.42523502907657	IGF1/PDGFRA/PDGFRB/AKT3/PRKCA/FGF10/GNG2/RAC2/FGF2/HGF/ETS1/PLCG2/RASSF5/RASA3/FASLG/RASAL3/CALML4/PRKCB/PIK3R1/ZAP70/PIK3CD/PLAAT2/SYNGAP1/FGF7/GNGT2/RAC3/PAK3/RASGRP1/GNG11/CSF1/FLT3LG/ANGPT1/CALM3/PDGFD/GNB2/IKBKG/PLA2G2A/GNGT1/RAB5B	2.39497088248398
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	23/1078	125/9376	1.60035621521336	AKT3/PRKCA/FCER1G/RAC2/FYN/S1PR3/PPP2R2B/PRKCB/TNF/PIK3R1/PIK3CD/GNAI2/BDKRB2/RAC3/GNAQ/PLCB4/MAPK12/BID/S1PR4/SPTLC2/PPP2R5D/ORMDL1/BAX	2.43544306062227
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	25/1078	139/9376	1.56431441117978	AKT3/ADCY3/ITPR2/MMP2/PGR/FOS/ADCY1/GABBR1/HSP90B1/CALML4/HSP90AA1/PIK3R1/PIK3CD/CREB3L2/GNAI2/ADCY5/NCOA1/HSPA1A/GREB1/GNAQ/PLCB4/ESR1/CALM3/ITPR3/HSP90AB1	2.41585782916386
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	40/1078	248/9376	1.40283679454186	AKT3/MYL9/PTPRC/FLNA/FOS/LEF1/BIRC3/RHOH/TUBB6/MYC/CXCL8/NCKAP1L/PFN2/HSP90B1/PIK3CG/HSP90AA1/DYNC2H1/CD14/TNF/PIK3CD/IL1B/PYCARD/KIF5C/RAB7B/CTNNB1/CYFIP2/PAK3/DYNLRB2/MAPK12/WASF3/ELMO1/TCF7/ACTB/PLEKHM2/HSP90AB1/IKBKG/FHOD1/BAX/RAB5B/TCF7L2	2.31726370625374
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	47/1078	300/9376	1.362622139765	IGF1/PDGFRA/PDGFRB/AKT3/CACNA2D1/PRKCA/CACNA1D/FGF10/FLNA/PPP3CA/RAC2/FOS/FGF2/HGF/ARRB1/ERBB4/DUSP1/TGFB1/CACNA1C/MYC/FASLG/CACNA1G/PTPN7/GADD45A/CACNB2/CD14/PRKCB/TNF/IL1B/AREG/HSPA1A/FGF7/NLK/RAC3/MAPK12/RASGRP1/CSF1/FLT3LG/ANGPT1/RAPGEF2/PDGFD/MEF2C/CDC25B/IKBKG/IL1R1/FAS/EREG	2.30078482025918
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	5/1078	14/9376	3.10628147362841	CHST6/CHST2/ST3GAL3/ST3GAL2/B3GNT7	2.8425257699896
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	18/1078	93/9376	1.68340415345024	SNAI2/MYL9/RAC2/HEG1/CTNNA3/LEF1/FYN/RADIL/WAS/CTNNB1/NLK/RAC3/WASF3/ACTN1/TCF7/ACTB/PTPRJ/TCF7L2	2.3871692766096
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	15/1078	75/9376	1.73951762523191	AKT3/REV3L/CDKN2A/BIRC3/TOP2A/FASLG/GSTA3/PIK3R1/PIK3CD/BID/MDM2/ATM/BRCA1/FAS/BAX	2.31751547113962
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	17/1078	89/9376	1.66133705780576	PLCL1/ADCY3/PRKCA/CACNA1D/GNG2/ADCY1/CACNA1C/GABBR1/PRKCB/GABRA2/GNAI2/ADCY5/GNGT2/GNG11/GNB2/GNGT1/GPHN	2.25937564451369
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	15/1078	77/9376	1.69433534925186	AKT3/CDKN2A/STAT1/RAC2/CDK6/TGFB1/GADD45A/PIK3R1/PIK3CD/BRCA2/E2F1/RAC3/IKBKG/ARHGEF6/BAX	2.20498083089385
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	10/1078	45/9376	1.93279736136879	TAP1/TAP2/ABCC8/ABCC9/ABCC4/ABCG2/ABCA8/ABCB1/ABCA2/ABCA1	2.26067314083868
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	18/1078	99/9376	1.58137965930174	IGF1/AKT3/ADCY3/MMP2/CDKN2A/FOS/ADCY1/JAG1/PIK3R1/PIK3CD/ADCY5/E2F1/MAPK12/ESR1/CDKN2C/MDM2/JAG2/BAX	2.09595500627708
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	17/1078	93/9376	1.58988170048078	ADCY3/PRKCA/CACNA1D/ITPR2/MMP2/ADCY1/CACNA1C/CALML4/PRKCB/EGR1/ADCY5/GNAQ/PLCB4/MAPK12/MMP14/CALM3/ITPR3	2.06049007035261
Organismal Systems	Digestive system	hsa04970	Salivary secretion	17/1078	93/9376	1.58988170048078	PRKG1/ADCY3/PRKCA/ITPR2/ADCY1/CST3/CALML4/PRKCB/CD38/SLC12A2/LYZ/ADCY5/GNAQ/PLCB4/ATP1B1/CALM3/ITPR3	2.06049007035261
Cellular Processes	Cell motility	hsa04814	Motor proteins	31/1078	194/9376	1.38982078304611	KIF26B/STARD9/MYL9/TPM2/TUBB6/KIF9/DNAI1/TNNC1/KIF4A/DNAH9/DNAH10/DYNC2H1/DNAH2/DNAH12/DNAH3/KIF5C/ACTA2/DNAI2/KIF19/MYO1G/DYNLRB2/KIF6/KIF23/KIF15/ACTB/KIF18A/MYO1F/DNAH11/TNNC2/KIF17/KIF27	1.97745001150579
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	20/1078	115/9376	1.51262402194079	PRKCA/CACNA1D/ITPR2/GNG2/DUSP1/CACNA1C/APP/PRKCB/GNAI2/MAOB/ADCY5/KCND2/GNGT2/GNAQ/PLCB4/GNG11/TRPC1/ITPR3/GNB2/GNGT1	1.99355047057675
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	16/1078	87/9376	1.59955643699486	AKT3/RAC2/FOS/LEF1/TGFB1/MYC/GADD45A/PIK3R1/PIK3CD/AREG/CTNNB1/RAC3/TCF7/EREG/BAX/TCF7L2	2.02494633607495
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	12/1078	60/9376	1.73951762523191	AKT3/PRKCA/PPP3CA/RAC2/SH2D2A/PLCG2/PRKCB/PIK3R1/NFATC2/PIK3CD/RAC3/MAPK12	2.07117939938971
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	28/1078	174/9376	1.3996118823705	MAN1A1/HSPA5/PDIA6/HSP90B1/HSP90AA1/DNAJC10/PDIA3/ERO1B/UBXN6/HSPA1A/PDIA4/BAG2/LMAN1/STT3B/SEC24D/MAN1C1/DERL3/BCAP31/TXNDC5/SEC13/CALR/UBE2D1/HSP90AB1/SIL1/HERPUD1/BAX/HSPA4L/UGGT1	1.91769796085637
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	19/1078	109/9376	1.51609334309203	CCL4/AKT3/CCL3/STAT1/FOS/CXCL8/IRF9/CCL5/CD14/TNF/PIK3R1/PIK3CD/IL1B/IFNAR2/CCL3L1/MAPK12/IRF3/CCL4L2/IKBKG	1.95335072532901
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	18/1078	102/9376	1.53486849285169	ADCY3/PRKCA/ITPR2/ADCY1/RYR2/ATP2A3/PRKCB/CD38/SLC12A2/ADCY5/GNAQ/PLCB4/ATP1B1/TRPC1/ITPR3/SLC4A4/PLA2G2A/CEL	1.95759054808756
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	12/1078	62/9376	1.68340415345024	ATXN1/JAG1/TLE4/DTX1/APH1B/NUMBL/MFNG/MAML2/CIR1/MAML3/LFNG/JAG2	1.9458692059564
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	10/1078	49/9376	1.77501798493052	GALNT13/GALNT17/ST6GAL2/GXYLT2/GALNT18/ST3GAL3/MFNG/GALNT2/LFNG/GALNT3	1.96041102298753
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	25/1078	155/9376	1.40283679454186	ADCY3/CACNA1D/ITPR2/CDKN2A/CDK6/WNT4/ADCY1/LEF1/CACNA1C/WNT5A/CACNA1G/CREB3L2/GNAI2/ADCY5/E2F1/WNT2/CTNNB1/GNAQ/PLCB4/CDKN2C/PDE8B/TCF7/ITPR3/FZD2/TCF7L2	1.82269613636355
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	27/1078	170/9376	1.38138164356652	AKT3/PRKCA/CDKN2A/CDK6/WNT4/LEF1/HGF/PLCG2/TGFB1/WNT5A/MYC/GADD45A/GSTA3/PRKCB/PIK3R1/ARID1B/PIK3CD/E2F1/WNT2/CTNNB1/NQO1/DPF3/TCF7/FZD2/ACTB/BAX/TCF7L2	1.80866054509096
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	11/1078	56/9376	1.70845481049563	CCND2/ARRB1/GRK3/GPR161/GLI3/SMO/FBXW11/CSNK1G2/PTCH1/GLI2/HHAT	1.91648980917492
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	11/1078	56/9376	1.70845481049563	ITGB2/CXCL8/CXCL3/CD14/TNF/IL1B/PYCARD/HSPA1A/ITGAM/CR1L/CXCL2	1.91648980917492
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	16/1078	91/9376	1.52924626394014	AKT3/PPP3CA/RAC2/IFITM1/FOS/PLCG2/PIK3AP1/INPP5D/PRKCB/PIK3R1/NFATC2/PIK3CD/VAV3/RAC3/CARD11/IKBKG	1.82850371243309
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	24/1078	149/9376	1.40095379213308	ADCY3/PRKCA/CACNA1D/ITPR2/GNG2/ADCY1/CACNA1C/GRIA1/PRKCB/GABRA2/GNAI2/ADCY5/GNGT2/GRIA3/GNAQ/PLCB4/MAPK12/GNG11/GRM5/DAGLA/ITPR3/NAPEPLD/GNB2/GNGT1	1.77813816111598
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	11/1078	57/9376	1.67848191908342	HACD3/FADS2/FADS1/SCD5/ACSL4/ACAA2/FASN/HACD4/ELOVL5/ACADVL/ACSBG1	1.85182248889826
NA	NA	hsa04981	Folate transport and metabolism	7/1078	31/9376	1.96397151235861	TYMS/ABCC4/MTHFS/ABCG2/BHMT2/DHFR/SLC46A1	1.93759808736684
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	10/1078	51/9376	1.70540943650187	PLPP3/PLPP1/PLA2G7/PLAAT2/CHPT1/ENPP2/LPCAT4/PLA2G2A/SELENOI/PAFAH2	1.82058196517797
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	12/1078	65/9376	1.60570857713715	ADCY3/CACNA1D/ITPR2/ADCY1/CACNA1C/CACNA1G/CREB3L2/ADCY5/GNAQ/PLCB4/PDE8B/ITPR3	1.76616202227736
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	11/1078	59/9376	1.6215842269111	AKT3/CTNNA3/LEF1/MYC/GADD45A/PIK3R1/PIK3CD/CTNNB1/TCF7/BAX/TCF7L2	1.72622040880857
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	14/1078	80/9376	1.52207792207792	IGF1/PDGFRA/PDGFRB/AKT3/PRKCA/AXL/FGF2/HGF/PLCG2/PRKCB/PIK3R1/PIK3CD/PDGFD/BAX	1.69020961243392
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	5/1078	20/9376	2.17439703153989	SQLE/LIPA/SOAT1/CEL/FDFT1	1.89492986039933
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	13/1078	73/9376	1.54888555671335	BST2/MX1/MAP1B/APOBEC3G/MX2/NUP153/SAMHD1/MDFIC/MAP1A/APOBEC3H/CD4/CHMP6/FEZ1	1.69683661090635
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	35/1078	238/9376	1.2790570773764	C1R/NRP1/PRKCA/MX1/C1S/CFD/OAS2/STAT1/C1QA/ISG15/FOS/MX2/C1QB/MASP1/PLCG2/CXCL8/C1QC/IRF9/PRKCB/TNF/PIK3R1/C6/PIK3CD/IL1B/IFNAR2/CSF2/OAS3/CCL2/MAPK12/IRF3/C5AR1/ADAR/IKBKG/OAS1/RPLP1	1.5716804335685
Organismal Systems	Nervous system	hsa04730	Long-term depression	11/1078	60/9376	1.59455782312925	IGF1/PRKG1/PRKCA/ITPR2/GRIA1/PRKCB/GNAI2/GRIA3/GNAQ/PLCB4/ITPR3	1.66518805366555
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	25/1078	163/9376	1.33398590892018	AKT3/PRKCA/STAT1/FOS/TGFB1/MYC/CXCL8/FASLG/STAT4/PRKCB/TNF/PIK3R1/NFATC2/PIK3CD/CREB3L2/E2F1/PCNA/MAPK12/NFATC4/IRF3/BID/JAK3/IKBKG/FAS/BAX	1.55034985877366
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	6/1078	27/9376	1.93279736136879	HACD3/FADS2/FADS1/SCD5/HACD4/ELOVL5	1.74942333233912
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	4/1078	15/9376	2.31935683364255	ST6GALNAC3/ST3GAL5/ST8SIA1/ST3GAL2	1.84312623599907
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	23/1078	150/9376	1.33363017934446	AKT3/FGF10/CTNNA3/WNT4/LEF1/FGF2/HGF/TGFB1/WNT5A/MYC/GADD45A/PIK3R1/PIK3CD/FGF7/E2F1/WNT2/CTNNB1/ABCB1/RARB/TCF7/FZD2/BAX/TCF7L2	1.4846105304044
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	16/1078	98/9376	1.42001438794442	INPP4B/DGKB/PRKCA/ITPR2/PIP5K1B/PLCG2/INPP5D/CALML4/PRKCB/PIK3R1/PIK3CD/DGKD/PIP4P2/PLCB4/CALM3/ITPR3	1.50646249843558
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	20/1078	128/9376	1.35899814471243	ADCY3/PDE4B/ADCY1/RRM2/ENPP1/NUDT16/XDH/PDE7A/ADCY5/PDE4A/PDE3B/AK8/ADA/PDE8B/PDE4D/GMPS/ADK/NUDT5/ENTPD6/ENTPD2	1.47394603048512
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	14/1078	85/9376	1.43254392666157	UCK2/TYMS/RRM2/ENPP1/NUDT16/XDH/AK8/TK1/ADA/CMPK2/GMPS/ADK/ENTPD6/ENTPD2	1.44383230491984
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	12/1078	71/9376	1.47001489456218	PDGFRA/PDGFRB/AKT3/NTRK3/SLC1A5/MYC/LDHB/PIK3R1/PIK3CD/IDH2/SCO2/PFKM	1.43281760736205
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	7/1078	36/9376	1.69119769119769	GALNT13/ST6GALNAC3/GALNT17/GALNT18/GALNT2/ST3GAL2/GALNT3	1.49757435502335
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	35/1078	250/9376	1.21766233766234	HLA-A/PDGFRA/HLA-C/IL2RB/PIP5K1B/WIPF1/RAB31/PSD3/SH3KBP1/IL2RG/HLA-F/ARRB1/EHD2/GRK3/MVB12B/HLA-B/DAB2/WIPF3/KIF5C/EPN1/PARD6G/NEDD4/HSPA1A/HLA-E/GRK5/RAB4A/MDM2/ASAP1/IQSEC1/WASHC5/VPS37B/CHMP6/EPN2/RAB5B/ZFYVE27	1.25724919036286
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	17/1078	110/9376	1.34417271040648	IGF1/AKT3/ADCY3/PGR/ANAPC4/ADCY1/HSP90AA1/PIK3R1/PIK3CD/GNAI2/ADCY5/PDE3B/MAPK12/CDK1/HSP90AB1/CDC25B/SPDYE2	1.30868441356719
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	9/1078	51/9376	1.53486849285169	ADCY3/PRKCA/PLCG2/KDELR2/SLC12A2/ATP6V0B/PDIA4/ACTB/TJP2	1.38043507988302
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	7/1078	37/9376	1.64548964548965	LEF1/MYC/GADD45A/CTNNB1/TCF7/BAX/TCF7L2	1.4179086688114
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	10/1078	59/9376	1.47416747901009	PRKG1/AKT3/ADCY3/ADCY1/PIK3R1/PIK3CD/GNAI2/PLAAT2/ADCY5/PDE3B	1.3168248871566
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	9/1078	53/9376	1.4769489270837	PRKCA/SLC8A1/PTH1R/PRKCB/BDKRB2/GNAQ/PLCB4/ESR1/ATP1B1	1.25499002005587
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	8/1078	46/9376	1.51262402194079	PSMB9/IFNG/PSMD6/PSMB8/PSMD13/PSMD11/PSMA5/PSMD3	1.25616113098269
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	13/1078	83/9376	1.36227283903704	CCL4/SAMHD1/CCL5/IL1B/PYCARD/ZDHHC11/GSDME/DDX41/IRF3/IFI16/CCL4L2/ADAR/IKBKG	1.19482735098132
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	7/1078	39/9376	1.56110556110556	MTHFD2/TYMS/MTHFS/MAT2A/BHMT2/ALDH1L1/DHFR	1.26555638855777
Organismal Systems	Digestive system	hsa04978	Mineral absorption	10/1078	61/9376	1.42583411904255	SLC40A1/MT1G/MT1M/SLC8A1/MT1F/MT1H/MT1X/HEPH/ATP1B1/SLC46A1	1.20260289969875
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	12/1078	76/9376	1.37330338834098	FABP5/PLTP/FADS2/FABP6/SCD5/ACSL4/CYP27A1/SLC27A2/ME3/ME1/ACSBG1/PLIN5	1.1777023919529
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	20/1078	138/9376	1.26052001828399	IGF1/ADCY3/ITPR2/PGR/PPP3CA/ANAPC4/ADCY1/AR/CALML4/PPP1CB/ADCY5/MAPK12/CDK1/FBXW11/SGO1/CALM3/ITPR3/PTTG1/SPDYE2/PPP2R5D	1.1112197908832
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	8/1078	47/9376	1.48044053211226	CACNA1D/ABCC8/CACNA1C/CACNA1G/TNF/PIK3R1/PIK3CD/SOCS3	1.19008868235891
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	12/1078	77/9376	1.35546827940149	AKT3/CDKN2A/CDK6/TGFB1/MYC/GADD45A/PIK3R1/PIK3CD/E2F1/MDM2/IKBKG/BAX	1.12885040768217
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	37/1078	275/9376	1.17022094788329	CACNA1D/ITPR2/C1QA/PRNP/PPP3CA/RAC2/C1QB/TUBB6/FYN/CACNA1C/HSPA5/COX7A1/C1QC/RYR2/CCL5/TNF/PIK3R1/C6/PIK3CD/NCAM1/CREB3L2/IL1B/EGR1/NCF1/KIF5C/HSPA1A/PSMD6/GRIN3B/MAPK12/NCAM2/ITPR3/PSMD13/PSMD11/CYBA/PSMA5/BAX/PSMD3	1.03262609972582
NA	NA	hsa04081	Hormone signaling	30/1078	219/9376	1.19145042824103	IGF1/RAMP1/PRKG1/SLC40A1/ADCY3/GNG2/ADRA2C/ADCY1/PRLR/PTH1R/PIK3R1/PIK3CD/GNAI2/GHR/ADCY5/HEPH/RAMP2/DIO2/GNGT2/GNAQ/PLCB4/GNG11/ESR1/OPRK1/SLC16A2/GIPR/GNB2/AVPR1A/GNGT1/ITGAV	1.03326113892937
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	12/1078	78/9376	1.33809048094762	FN1/CTNNA3/SEPTIN6/PIK3R1/PIK3CD/ITGA5/CTNNB1/ELMO1/HCLS1/ARHGAP10/ACTB/ELMO3	1.08067169617644
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	34/1078	253/9376	1.16884583513607	AKT3/ITPR2/MYL9/PLCG2/CXCL8/PFN2/CCL5/CD14/SEPTIN6/TNF/PIK3R1/PIK3CD/IL1B/PYCARD/ITGA5/CSF2/PLCB4/MAPK12/ELMO1/ACTN1/HCLS1/IRF3/FBXW11/ATG12/MDM2/ATM/ITPR3/ACTB/UBE2D1/IKBKG/IL1R1/BAX/PRKCQ/TIFA	0.981273519147678
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	11/1078	71/9376	1.34751365334866	AKT3/CCND2/STAT1/FOS/PRLR/PIK3R1/PIK3CD/IRF1/MAPK12/ESR1/SOCS3	1.05937851561172
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	9/1078	56/9376	1.39782666313279	MAN1A1/ST6GAL2/MGAT5/STT3B/ALG13/MAN1C1/MGAT1/DPAGT1/MGAT4A	1.07618825423552
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	6/1078	34/9376	1.53486849285169	RORB/RORA/BHLHE41/PRKAG2/FBXW11/CRY1	1.1260945234601
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	7/1078	42/9376	1.44959802102659	SLC40A1/PRNP/ACSL4/ATG7/SLC39A8/PCBP2/STEAP3	1.05250323957492
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	15/1078	104/9376	1.2544598258884	DGKB/PLPP3/AGPAT4/PLPP1/MBOAT2/PEMT/PLAAT2/DGKD/CHPT1/GDPD5/GNPAT/LPCAT4/PLA2G2A/SELENOI/PNPLA6	0.940497157344853
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	5/1078	28/9376	1.55314073681421	AKR1C3/AKR1B1/DHFR/GGH/GPHN	1.05648567079244
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	17/1078	120/9376	1.2321583178726	AKT3/NTRK3/ARHGDIB/PLCG2/TP73/MATK/FASLG/CAMK4/CALML4/PIK3R1/PIK3CD/MAGED1/SH2B3/IRAK3/MAPK12/CALM3/BAX	0.922510890457585
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	20/1078	144/9376	1.20799835085549	RORA/AKT3/PRKCA/ITPR2/ATXN1/GRIA1/ATP2A3/PRKCB/PIK3R1/PIK3CD/GRIA3/PSMD6/GNAQ/GRIN3B/PLCB4/ITPR3/PSMD13/PSMD11/PSMA5/PSMD3	0.906570416950814
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	4/1078	21/9376	1.65668345260182	ENPP1/DPYD/BCAT1/PPCDC	1.08580572632739
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	29/1078	217/9376	1.16235048690612	AKT3/ADCY3/PRKCA/CACNA1D/FGF10/PGR/FOS/ADCY1/FGF2/ARRB1/JAG1/CACNA1C/MYC/AR/HSP90B1/HSP90AA1/GSTA3/PRKCB/CYP1B1/PIK3R1/PIK3CD/CREB3L2/GNAI2/ADCY5/FGF7/E2F1/ESR1/CDC6/HSP90AB1	0.872102911250181
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	7/1078	43/9376	1.41588643914225	ECI2/ACSL4/ACAA2/ACADVL/ADH4/ADH6/ACSBG1	0.985159745243469
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	5/1078	29/9376	1.49958415968268	RASSF2/WWTR1/FRMD6/TEAD2/RASSF4	0.971135523738612
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	7/1078	44/9376	1.38370720188902	MAN1A1/ST3GAL3/STT3B/ALG13/MAN1C1/MGAT1/MGAT4A	0.919490459052027
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	6/1078	37/9376	1.41041969613398	MAOB/GOT1/ADH4/FAH/ADH6/ALDH3B1	0.901544508212638
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	27/1078	205/9376	1.14553599710394	HLA-A/HLA-C/CCND2/CDKN2A/CDK6/HLA-F/HLA-B/IRF9/PIK3R1/PIK3CD/CREB3L2/TRAF1/HLA-E/CDK1/ACTN1/CHEK1/LTBR/IRF3/MDM2/HDAC4/JAK3/GTF2H2/RANBP1/IKBKG/HDAC6/GTF2H4/BAX	0.759359294204413
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	6/1078	38/9376	1.37330338834098	IGF1/PRKCA/PRKCB/PIK3R1/PIK3CD/ATP1B1	0.831065203277275
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	15/1078	109/9376	1.19691579717792	AKT3/PRKCB/TNF/PPP1CB/PIK3R1/PIK3CD/CREB3L2/SLC27A2/SLC27A3/GFPT2/PRKAG2/SOCS3/GFPT1/SREBF1/PRKCQ	0.745302415531525
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	3/1078	16/9376	1.63079777365492	MAOB/GOT1/ALDH3B1	0.910165820076164
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	3/1078	16/9376	1.63079777365492	ST8SIA1/A4GALT/ST3GAL2	0.910165820076164
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	9/1078	62/9376	1.26255311508768	IGF1/AKT3/ADCY3/ADCY1/PIK3R1/PIK3CD/ADCY5/HSPA1A/PRKAG2	0.747572309880966
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	15/1078	110/9376	1.1860347444763	IGF1/AKT3/PRKCA/PLCG2/TIMP1/PRKCB/LDHB/PIK3R1/SERPINE1/PIK3CD/IFNG/LTBR/ANGPT1/EGLN1/PFKM	0.707379647243268
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	26/1078	200/9376	1.13068645640074	WIPF1/FOS/TUBB6/FYN/CXCL8/NCKAP1L/FASLG/TNF/WIPF3/IL1B/PYCARD/F2R/MYO1G/CYFIP2/PAK3/MAPK12/WASF3/SEC24D/HCLS1/ACTB/IKBKG/IL1R1/MYO1F/FAS/TMED10/BAX	0.673328784679563
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	19/1078	143/9376	1.15562359718204	HLA-DRA/C1R/C1S/C1QA/C1QB/HLA-DRB5/HLA-DPA1/C1QC/HLA-DPB1/HLA-DQA2/HLA-DQA1/TNF/C6/IFNG/HLA-DRB1/FCGR3A/HLA-DQB1/HLA-DMA/ACTN1	0.675896743475501
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	4/1078	24/9376	1.44959802102659	XYLT1/HS6ST1/EXT1/HS2ST1	0.794851624386577
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	7/1078	48/9376	1.26839826839827	AKT3/CACNA1D/PRKCB/PIK3R1/PIK3CD/PLCB4/ATP1B1	0.671915040949187
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	6/1078	41/9376	1.27281777455993	RAD51B/BRIP1/BRCA2/ATM/BRCA1/BLM	0.630980201668834
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	6/1078	41/9376	1.27281777455993	MMP2/CDKN2A/MYC/CXCL8/E2F1/MDM2	0.630980201668834
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	3/1078	18/9376	1.44959802102659	ACSL4/FASN/ACSBG1	0.688140987671835
NA	NA	hsa04082	Neuroactive ligand signaling	25/1078	199/9376	1.09266182489442	ADCY3/PRKCA/P2RY14/GNG2/ADRA2C/ADCY1/GABBR1/GRIA1/PRKCB/GRM7/GABRA2/GNAI2/ADCY5/GNGT2/GRIA3/GNAQ/GRIN3B/PLCB4/GNG11/GRM5/OPRK1/GNB2/P2RX4/GNGT1/GRIK2	0.476195541324083
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	8/1078	59/9376	1.17933398320808	UCK2/TYMS/RRM2/ENPP1/DPYD/TK1/CMPK2/ENTPD6	0.498033843852647
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	14/1078	110/9376	1.10696576151122	DCN/FBN1/GDF7/EMP3/TGFB1/MYC/TNF/BMP8A/IFNG/GREM2/CHRD/NBL1/TGIF2/LEMD3	0.406727264081306
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	6/1078	44/9376	1.1860347444763	ADCY3/ARHGDIB/DYNC2H1/CREB3L2/AQP3/RAB5B	0.445801308278851
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	11/1078	86/9376	1.1124822021832	AKT3/PRKCA/PLCG2/ERBB4/MYC/PRKCB/PIK3R1/PIK3CD/AREG/PAK3/EREG	0.37768825731008
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	4/1078	28/9376	1.24251258945136	HACD3/ACAA2/HACD4/ELOVL5	0.463193286427928
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	3/1078	20/9376	1.30463821892393	CMAS/UGDH/GMDS	0.491544207073571
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/1078	12/9376	1.44959802102659	NCAM1/NCAM2	0.561684726852267
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	9/1078	70/9376	1.11826133050623	AKT3/TNFRSF1B/ACSL4/TNF/PRKAG2/SOCS3/IKBKG/ACSBG1/PRKCQ	0.357946862475982
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	9/1078	70/9376	1.11826133050623	AKT3/HGF/ETS1/TGFB1/PIK3R1/PIK3CD/ARNT2/PAK3/EGLN1	0.357946862475982
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	11/1078	87/9376	1.09969505043397	CACNA2D1/CACNA1D/SLC8A1/TPM2/CACNA1C/COX7A1/TNNC1/RYR2/CACNB2/ATP2A3/ATP1B1	0.336710799258417
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	5/1078	37/9376	1.17534974677832	GFPT2/CMAS/UGDH/GFPT1/GMDS	0.385180347613878
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	7/1078	54/9376	1.12746512746513	REV3L/BRIP1/BRCA2/FANCA/BRCA1/BLM/FANCB	0.338564967863981
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	9/1078	71/9376	1.10251117092163	PLCG2/CXCL8/JAM3/CCL5/CXCL3/ATP6V0B/MAPK12/IKBKG/CXCL2	0.312500332111043
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	9/1078	72/9376	1.08719851576994	ISG15/CXCL8/TNF/RNF125/MAPK12/IRF3/ATG12/ADAR/IKBKG	0.267700260304389
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	13/1078	107/9376	1.05671631439322	AKT3/ITPR2/PPP3CA/CALML4/LDHB/CREB3L2/PDE3B/GNAQ/PLCB4/PRKAG2/CALM3/ITPR3/PFKM	0.212662910043844
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	11/1078	90/9376	1.06303854875283	IGF1/AKT3/ADCY3/ADCY1/CAMK4/PIK3R1/PIK3CD/CREB3L2/ADCY5/PRKAG2/BAX	0.216581533741438
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	16/1078	133/9376	1.04632639111694	IGF1/AKT3/CCND2/TGFB1/FASLG/GADD45A/PIK3R1/PIK3CD/NLK/MAPK12/PRKAG2/ATG12/MDM2/ATM/S1PR4/KLF2	0.193934965293272
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	3/1078	22/9376	1.1860347444763	HNMT/MAOB/ALDH3B1	0.31485821071408
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	8/1078	65/9376	1.0704723847581	DGKB/PLPP3/AGPAT4/PLPP1/MBOAT2/AKR1B1/DGKD/CEL	0.205487678855982
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	4/1078	31/9376	1.12226943563349	HSPA5/SRPRB/SPCS2/SRP68	0.245763512292199
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	17/1078	144/9376	1.02679859822717	IGF1/AKT3/TBX3/WNT4/FGF2/WNT5A/MYC/PIK3R1/PIK3CD/WNT2/MEIS1/CTNNB1/MAPK12/TCF7/FZD2/JAK3/PCGF5	0.116802927852929
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	6/1078	49/9376	1.06501079095831	FOSB/CREB3L2/GNAI2/MAOB/ADCY5/GRIN3B	0.164445049903248
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	3/1078	23/9376	1.13446801645559	MME/ENPEP/ANPEP	0.232710378661032
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	4/1078	32/9376	1.08719851576994	ATG7/ATG12/ATG10/ATG4B	0.178084438134646
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	8/1078	68/9376	1.02324566190112	ALDH1A3/ALDH1A1/ALDH1A2/CYP26A1/DHRS3/CYP2S1/ADH4/ADH6	0.0693388268155256
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	4/1078	33/9376	1.05425310620116	BCAT1/AADAT/GOT1/IDH2	0.112524400334581
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	5/1078	42/9376	1.03542715787614	CYP1B1/MAOB/AADAT/KYNU/KMO	0.082934525264206
NA	NA	hsa04519	Cadherin signaling	46/1078	404/9376	0.990319440107276	VIM/PDGFRA/LHFPL3/PDGFRB/CDH11/LHFPL6/PCDH18/KRT81/RAC2/CTNNA3/WNT4/LEF1/GJA1/PRICKLE1/WNT5A/CDH13/PRICKLE2/WWTR1/NCKAP1L/TMC8/PPP1CB/GABRA2/EVL/APH1B/PCDH9/MPDZ/PCDH7/MYO1G/VAV3/WNT2/CTNNB1/CYFIP2/RAC3/MAPK12/TEAD2/CDH2/ACTN1/ABI2/TCF7/FZD2/ACTB/FAT1/IKBKG/MYO1F/TMC6/TCF7L2	-0.0716893808718001
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	5/1078	43/9376	1.01134745653018	PLPP3/PLPP1/PLA2G2A/CEL/ABCA1	0.0268800718953245
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	6/1078	52/9376	1.00356786071072	IGF1/ADCY3/ADCY1/AKR1C3/CYP1B1/ADCY5	0.0092985821858262
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	22/1078	195/9376	0.981266352694924	AKT3/PRKCA/ITGB2/RAC2/PLCG2/ITGAL/PRKCB/PIK3R1/PIK3CD/SELPLG/NCF1/ATG7/FCGR3A/PLCB4/MAPK12/ITGAM/CR1L/C5AR1/ACTB/HDAC4/CYBA/HDAC6	-0.0952802646900051
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	3/1078	26/9376	1.00356786071072	FADS2/PLAAT2/PLA2G2A	0.00656594231779344
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	3/1078	26/9376	1.00356786071072	SLC23A1/SLC46A1/CUBN	0.00656594231779344
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	54/1078	480/9376	0.97847866419295	SNCAIP/PRKCA/CACNA1D/ITPR2/DKK1/ATXN1/PRNP/PPP3CA/WNT4/TUBB6/CACNA1C/WNT5A/DNAI1/HSPA5/COX7A1/FASLG/APP/RYR2/DNAH9/TNFRSF1B/GRIA1/DNAH10/CALML4/ATP2A3/DNAH2/PRKCB/TNF/DNAH12/IFT57/GPX8/IL1B/DNAH3/KIF5C/DNAI2/GRIA3/PSMD6/WNT2/CTNNB1/GNAQ/PLCB4/MAPK12/GRM5/CSF1/BID/CALM3/ITPR3/FZD2/PSMD13/PSMD11/DNAH11/FAS/PSMA5/BAX/PSMD3	-0.174461964708673
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	2/1078	17/9376	1.02324566190112	CYP7B1/CYP27A1	0.0345748223483108
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/1078	17/9376	1.02324566190112	PCDH9/PCDH7	0.0345748223483108
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	4/1078	36/9376	0.966398680684395	AKR1B1/XYLB/UGDH/CRYL1	-0.0728018550160472
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	6/1078	55/9376	0.948827795581042	PLPP3/PLPP1/PSAP/B4GALT6/GALC/SPTLC2	-0.137180543838986
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	3/1078	28/9376	0.931884442088524	ST8SIA1/ST3GAL3/A4GALT	-0.130099097936587
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	5/1078	47/9376	0.925275332570165	LDHB/ME3/ADH4/ADH6/ME1	-0.185098831296148
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	17/1078	157/9376	0.941777058246576	AKT3/FOS/TGFB1/CXCL8/COX7A1/FASLG/TNF/PIK3R1/PIK3CD/IL1B/MAPK12/PRKAG2/SOCS3/BID/FAS/SREBF1/BAX	-0.265161438729669
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	18/1078	168/9376	0.931884442088524	STAT1/TNFAIP3/BIRC3/FASLG/IRF9/STAT4/HSP90AA1/TNF/IL1B/IFNAR2/IFNG/PYCARD/BID/JAK3/HSP90AB1/FAS/CHMP6/BAX	-0.321089872031787
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/1078	29/9376	0.899750495809609	CALML4/CALM3/GNGT1	-0.19487378226385
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	35/1078	323/9376	0.942463109645772	ZEB1/VIM/PDGFRA/ZEB2/TIMP3/PDGFRB/PRKCA/CCND2/CDKN2A/MMP16/ZFPM2/CDK6/HOXD10/TNXB/PLCG2/MYC/RECK/PIM1/PRKCB/CYP1B1/PIK3R1/SLC7A1/PIK3CD/MARCKS/ITGA5/TNC/PLAU/E2F1/ABCB1/KIF23/MDM2/ATM/BRCA1/HDAC4/CDC25B	-0.379279780188098
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	15/1078	142/9376	0.918759309101361	KLHL13/ANAPC4/BIRC3/UBE2C/NEDD4/UBE2E3/SOCS3/FBXW11/MDM2/RHOBTB1/UBE2D1/BRCA1/PIAS1/UBA2/UBE2W	-0.351585656156731
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	18/1078	170/9376	0.920921095711012	CACNA1D/MYL9/RAB8B/JAM3/PPP2R2B/MPDZ/PARD6G/NEDD4/MSN/WAS/PCNA/ACTN1/HCLS1/PRKAG2/RAPGEF2/ACTB/CRB3/TJP2	-0.375023015788047
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	8/1078	78/9376	0.892060320631749	INPP4B/PIP5K1B/PLCG2/INPP5D/PIK3CG/PIK3CD/PLCB4/PLCH1	-0.345018162181561
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	42/1078	388/9376	0.941491498192529	MME/APOE/AKT3/CACNA1D/ITPR2/DKK1/LRP1/PPP3CA/WNT4/TUBB6/CACNA1C/WNT5A/COX7A1/APP/CALML4/ATP2A3/TNF/PIK3R1/PIK3CD/IL1B/APH1B/KIF5C/PSMD6/WNT2/CTNNB1/GNAQ/PLCB4/GRM5/CSF1/APBB1/BID/SLC39A8/SLC39A10/CALM3/ITPR3/FZD2/PSMD13/PSMD11/IKBKG/FAS/PSMA5/PSMD3	-0.424239997776211
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/1078	10/9376	0.869758812615955	ETHE1	-0.148518164620292
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	4/1078	41/9376	0.848545183039957	GRIA1/GABRA2/GRIA3/GRIN3B	-0.350288726983843
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	3/1078	32/9376	0.815398886827458	ACSS3/SUCLA2/LDHB	-0.377008544561644
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	3/1078	32/9376	0.815398886827458	BIRC3/BID/BAX	-0.377008544561644
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	21/1078	205/9376	0.890972442191954	COL3A1/COL1A1/AKT3/PRKCA/MMP2/RAC2/TGFB1/COX7A1/RYR2/ATP2A3/COL1A2/PRKCB/PPP1CB/PIK3R1/PIK3CD/NCF1/PLCB4/MAPK12/GFPT2/CYBA/GFPT1	-0.568870183277194
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	8/1078	83/9376	0.838321747099716	FAR2/ECI2/ACSL4/XDH/SLC27A2/GNPAT/PEX10/IDH2	-0.533237874353542
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	5/1078	54/9376	0.805332233903662	BCAT1/LDHB/MAT2A/BHMT2/GOT1	-0.5170644495734
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	12/1078	122/9376	0.85550047142553	IGF1/AKT3/PPP2R2B/SCD5/PIK3R1/PIK3CD/CREB3L2/FASN/PRKAG2/PPP2R5D/PFKM/SREBF1	-0.579015115486929
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/1078	23/9376	0.756312010970396	ST3GAL3/LARGE1	-0.421726487063573
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	2/1078	23/9376	0.756312010970396	PCNA/LIG1	-0.421726487063573
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/1078	23/9376	0.756312010970396	ATP1B1/SLC4A4	-0.421726487063573
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	4/1078	44/9376	0.790689829650869	TAF3/GTF2F2/GTF2H2/GTF2H4	-0.501576993267501
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/1078	12/9376	0.724799010513296	NQO1	-0.343809770906821
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	3/1078	35/9376	0.745507553670819	AKR1B1/PFKM/GMDS	-0.543651431533759
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	15/1078	154/9376	0.847167674625931	MTHFD2/DHRS3/BCAT1/MAT2A/AK8/NQO1/DHFR/CMPK2/PPCDC/KYNU/KMO/UGDH/GGH/COX10/GPHN	-0.68924135236555
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	6/1078	67/9376	0.778888488909811	LDHB/ENO4/ADH4/ADH6/ALDH3B1/PFKM	-0.65464452813224
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	3/1078	36/9376	0.724799010513296	PCNA/LIG1/MCM7	-0.596260591695846
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	7/1078	78/9376	0.780552780552781	NUDT16/BTG4/CNOT9/DCPS/PFKM/PAN3/TENT4B	-0.701440626771062
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	3/1078	37/9376	0.705209848066991	GFPT2/GOT1/GFPT1	-0.647547973583641
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	13/1078	138/9376	0.819338011884596	AKT3/CALML4/PRKAR2B/PPP1CB/PIK3R1/PIK3CD/FASN/PDE3B/PRKAG2/SOCS3/RHOQ/CALM3/SREBF1	-0.770594052528045
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	5/1078	59/9376	0.737083739505047	RRM2/GSTA3/ANPEP/GPX8/IDH2	-0.730152721103277
Organismal Systems	Digestive system	hsa04976	Bile secretion	8/1078	90/9376	0.773118944547516	ADCY3/ADCY1/ABCC4/ABCG2/ADCY5/ABCB1/ATP1B1/SLC4A4	-0.779495212674384
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	3/1078	38/9376	0.686651694170491	GFPT2/UGDH/GFPT1	-0.697590436127851
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/1078	15/9376	0.579839208410637	AK8	-0.586959765978143
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	7/1078	82/9376	0.742477035159962	UCK2/RRM2/DPYD/GSTA3/XDH/TK1/GMPS	-0.844169893106755
Human Diseases	Substance dependence	hsa05034	Alcoholism	18/1078	191/9376	0.819667990946974	GNG2/CAMK4/CALML4/FOSB/PPP1CB/CREB3L2/GNAI2/MAOB/ADCY5/GNGT2/GRIN3B/GNG11/CALM3/GNB2/CAMKK1/HDAC4/GNGT1/HDAC6	-0.907524227310706
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	5/1078	63/9376	0.690284771917425	CETN2/PCNA/GTF2H2/GTF2H4/LIG1	-0.888988894974765
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	2/1078	30/9376	0.579839208410637	SUCLA2/IDH2	-0.830752324279815
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	2/1078	30/9376	0.579839208410637	PGAP1/PIGF	-0.830752324279815
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/1078	30/9376	0.579839208410637	PLAAT2/PLA2G2A	-0.830752324279815
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	6/1078	75/9376	0.695807050092764	BCAT1/ENO4/MAT2A/GOT1/IDH2/PFKM	-0.953286092945437
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/1078	31/9376	0.561134717816745	DPYD/ALDH3B1	-0.882126204424226
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	2/1078	32/9376	0.543599257884972	AKR1B1/PFKM	-0.932101527257933
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/1078	19/9376	0.457767796113661	HPSE2	-0.852711453588462
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	6/1078	79/9376	0.660576313379207	GSTA3/CYP1B1/CYP2S1/ADH4/ADH6/ALDH3B1	-1.09192442252515
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/1078	46/9376	0.567234008227797	HEPH/BLVRA/COX10	-1.06047277226154
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	6/1078	83/9376	0.628741310324787	AUTS2/SFMBT2/PHF19/UBE2D1/PHC1/PCGF5	-1.22446396448749
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	13/1078	158/9376	0.715624339494141	IGF1/AKT3/PRKCA/WNT4/WNT5A/PRKCB/TNF/PIK3R1/PIK3CD/WNT2/FZD2/SEC13/PRR5L	-1.29930442549145
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/1078	36/9376	0.483199340342198	ENPP1/PGM2L1	-1.11971932837565
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5/1078	73/9376	0.595725214120517	GSTA3/MAOB/ADH4/ADH6/ALDH3B1	-1.24978376486027
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	34/1078	370/9376	0.799237827809256	CALCRL/EDNRA/GZMA/P2RY14/ADRA2C/PTGER4/S1PR3/NR3C1/GABBR1/PTGER2/GRIA1/PRLR/P2RY10/PTH1R/GRM7/GABRA2/P2RY8/GHR/F2R/BDKRB2/PGRMC1/GRIA3/GRIN3B/GRM5/PTGDR/OPRK1/C5AR1/GIPR/S1PR4/P2RX4/AVPR1A/NPW/GRIK2/TMEM97	-1.42012011871527
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	3/1078	50/9376	0.521855287569573	MAOB/P4HA2/GOT1	-1.2218136070977
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/1078	23/9376	0.378156005485198	GOT1	-1.07616335278818
Organismal Systems	Sensory system	hsa04742	Taste transduction	6/1078	86/9376	0.606808473918108	CACNA1C/GABBR1/GABRA2/PLCB4/ITPR3/ENTPD2	-1.32024284191283
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	4/1078	63/9376	0.55222781753394	PRDM6/AADAT/CAMKMT/SMYD3	-1.28525968889334
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	4/1078	63/9376	0.55222781753394	PTGDS/AKR1C3/PLAAT2/PLA2G2A	-1.28525968889334
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/1078	38/9376	0.457767796113661	ENPP1/CD38	-1.20714231592956
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/1078	26/9376	0.334522620236906	NR5A2	-1.22467956111481
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	7/1078	105/9376	0.579839208410637	RAB7B/MITF/CCZ1/E2F1/NBR1/TOMM70/RAB5B	-1.56046914204698
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	19/1078	235/9376	0.703209252753326	PRKG1/ADCY3/ADCY1/COX7A1/ACSL4/ARID1B/BMP8A/CREB3L2/SLC25A29/ADCY5/COX20/ZNF516/MAPK12/PRKAG2/DPF3/ACTB/COX10/COX16/NDUFAF5	-1.66071740506123
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	32/1078	368/9376	0.756312010970396	PPP3CA/NUP153/TUBB6/ERBB4/DNAI1/HSPA5/COX7A1/PFN2/DNAH9/TNFRSF1B/GRIA1/DNAH10/DNAH2/TNF/DNAH12/GPX8/DNAH3/KIF5C/DNAI2/PSMD6/MAPK12/BID/ITPR3/SEC13/PSMD13/ACTB/PSMD11/DNAH11/PSMA5/HDAC6/BAX/PSMD3	-1.71890608113286
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	26/1078	308/9376	0.734211984675807	TGM2/TUBB6/DNAI1/COX7A1/DNAH9/GRIA1/DNAH10/DNAH2/DNAH12/IFT57/CREB3L2/GPX8/DNAH3/KIF5C/DNAI2/GRIA3/PSMD6/GNAQ/PLCB4/GRM5/PSMD13/PSMD11/DNAH11/PSMA5/BAX/PSMD3	-1.70947715010375
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	2/1078	44/9376	0.395344914825434	PCNA/LIG1	-1.44895529481385
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	20/1078	250/9376	0.695807050092764	CTSW/LAPTM5/CTSC/CTSL/CD63/ACP5/ATP6V0B/CTSS/PSAP/OSBPL5/MCOLN2/MITF/SLC36A4/LIPA/OSBPL7/GPR155/GALC/NPC2/ABCA2/MCOLN3	-1.75706254050371
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/1078	31/9376	0.280567358908373	PFKM	-1.44607106278244
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/1078	31/9376	0.280567358908373	UGDH	-1.44607106278244
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	2/1078	48/9376	0.362399505256648	BCAT1/ACAA2	-1.59618527008897
NA	NA	hsa03272	Virion - Hepatitis viruses	2/1078	48/9376	0.362399505256648	CD63/DPP4	-1.59618527008897
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	21/1078	268/9376	0.681527427796085	SNCAIP/ITPR2/TUBB6/DUSP1/HSPA5/COX7A1/CALML4/GNAI2/MAOB/KIF5C/ADCY5/PSMD6/SLC39A8/SLC39A10/CALM3/ITPR3/PSMD13/PSMD11/PSMA5/BAX/PSMD3	-1.90649743356317
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/1078	33/9376	0.26356327655029	STX2	-1.52741670464526
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	6/1078	103/9376	0.506655618999586	PPP2R2B/PPP1CB/DDX39B/PPP2R5D/PNN/RNMT	-1.81454177848706
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	7/1078	116/9376	0.524854455888939	SUCLA2/ENO4/GOT1/ME3/IDH2/ME1/PFKM	-1.85591663935417
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/1078	66/9376	0.395344914825434	AKR1C3/CYP1B1/CYP7B1	-1.7766960643503
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	6/1078	108/9376	0.483199340342198	NUP153/THOC3/DDX39B/SEC13/NUP42/PNN	-1.9469295101729
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	11/1078	169/9376	0.566115203477841	AKT3/CTSL/PIK3R1/PIK3CD/ATG7/RAB7B/ATG12/NBR1/ATG10/ATG4B/PRKCQ	-2.05147872134654
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	16/1078	227/9376	0.613045859112568	AKT3/FOS/HGF/COX7A1/AKR1C3/GSTA3/CYP1B1/PIK3R1/PIK3CD/NCF1/PRKD3/MAPK12/NQO1/IKBKG/CYBA/PTPRJ	-2.12712943171223
NA	NA	hsa04382	Cornified envelope formation	15/1078	217/9376	0.60121576908937	COL4A1/KRT81/S100A4/COL4A2/COL4A6/S100A6/PPP2R2B/COL4A5/S100A1/S100A16/COL7A1/PCSK6/KAZN/SPTLC2/PPP2R5D	-2.14216104531266
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/1078	41/9376	0.212136295759989	MAOB	-1.82219211996286
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	3/1078	79/9376	0.330288156689603	STX2/ATP6V0B/SYT1	-2.15445988771533
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/1078	70/9376	0.248502517890273	GSTA3/CYP1B1	-2.27459106648229
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	4/1078	117/9376	0.297353440210583	ARID1B/DPF3/ACTB/INO80E	-2.75648806530636
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	4/1078	138/9376	0.252104003656799	PPA1/COX7A1/ATP6V0B/COX10	-3.19006899405679
Genetic Information Processing	Translation	hsa03010	Ribosome	6/1078	222/9376	0.235069949355664	MRPL37/MRPS25/MRPS2/MRPS28/MRPL42/RPLP1	-4.15720134652617
Genetic Information Processing	Transcription	hsa03040	Spliceosome	7/1078	243/9376	0.250547806103362	DDX5/HSPA1A/THOC3/TRA2A/SF1/DDX39B/PRPF38A	-4.26627303920063
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	1/1078	183/9376	0.047527803968085	UTP6	-4.68983458574012
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	9/1078	449/9376	0.174339182929702	PRKG1/ADCY3/SLC8A1/ARRB1/SLC24A4/GRK3/CALML4/RGS2/CALM3	-6.46219979976494