ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0005201 extracellular matrix structural constituent 54/2058 168/18639 0.321428571428571 2.91113077884215 1.3913062515273e-13 1.7377415081576e-10 GO:0005178 integrin binding 48/2058 161/18639 0.298136645962733 2.70017927312895 6.27818264045539e-11 3.92072505896439e-08 GO:0023023 MHC protein complex binding 20/2058 37/18639 0.540540540540541 4.89559530375857 1.640502742907e-10 6.82995975296946e-08 GO:0017124 SH3 domain binding 37/2058 115/18639 0.321739130434783 2.91394346558499 9.0931991226612e-10 2.83935142605096e-07 GO:0015631 tubulin binding 80/2058 385/18639 0.207792207792208 1.88194312975654 1.5324684032271e-08 3.82810607126131e-06 GO:0023026 MHC class II protein complex binding 15/2058 27/18639 0.555555555555556 5.03158406219631 2.00230739326996e-08 4.16813655699029e-06 GO:0008201 heparin binding 44/2058 172/18639 0.255813953488372 2.31686894026714 6.59549040662522e-08 1.17682393112499e-05 GO:0008017 microtubule binding 60/2058 276/18639 0.217391304347826 1.96888071998986 1.86982360182737e-07 2.91926209835299e-05 GO:0030020 extracellular matrix structural constituent conferring tensile strength 18/2058 44/18639 0.409090909090909 3.70507553670819 3.35608452261508e-07 4.65749952082915e-05 GO:0042605 peptide antigen binding 18/2058 45/18639 0.4 3.62274052478134 5.01775512551043e-07 6.26717615176253e-05 GO:0005539 glycosaminoglycan binding 53/2058 242/18639 0.21900826446281 1.98352528732863 7.46841369970492e-07 8.48004428266495e-05 GO:0003779 actin binding 83/2058 443/18639 0.187358916478555 1.69688184851496 8.89021979527988e-07 9.25323710358714e-05 GO:0005518 collagen binding 23/2058 72/18639 0.319444444444444 2.89316083576288 1.54281912827701e-06 0.000148229314709076 GO:0048407 platelet-derived growth factor binding 8/2058 11/18639 0.727272727272727 6.58680095414789 2.64538103059901e-06 0.000236005779087012 GO:0043394 proteoglycan binding 15/2058 37/18639 0.405405405405405 3.67169647781893 3.67464163296211e-06 0.000305975159971312 GO:0003777 microtubule motor activity 21/2058 68/18639 0.308823529411765 2.79696878751501 7.91535599816683e-06 0.000617892477606898 GO:1901681 sulfur compound binding 55/2058 275/18639 0.2 1.81137026239067 8.69194711214321e-06 0.000638602467239228 GO:0015026 coreceptor activity 19/2058 61/18639 0.311475409836066 2.82098647421498 1.84785931471457e-05 0.00128220904671028 GO:0042277 peptide binding 50/2058 249/18639 0.200803212851406 1.8186448417577 1.95307686893657e-05 0.00128389105752725 GO:0030695 GTPase regulator activity 84/2058 489/18639 0.171779141104294 1.55577813947665 2.47447468565213e-05 0.00154530944118976 GO:0060589 nucleoside-triphosphatase regulator activity 84/2058 490/18639 0.171428571428571 1.55260308204915 2.67029787484374e-05 0.00158819145032373 GO:0043178 alcohol binding 24/2058 92/18639 0.260869565217391 2.36265686398783 4.32862298717625e-05 0.00237182744537881 GO:0042608 T cell receptor binding 7/2058 11/18639 0.636363636363636 5.76345083487941 4.36765662479686e-05 0.00237182744537881 GO:0033218 amide binding 47/2058 247/18639 0.190283400809717 1.72336846826643 0.000134705341063704 0.00701029045785692 GO:0005516 calmodulin binding 41/2058 207/18639 0.198067632850242 1.7938691004352 0.000143783339892215 0.00718341566101508 GO:0140375 immune receptor activity 33/2058 156/18639 0.211538461538462 1.91587239291321 0.000173926053227501 0.00835514001850572 GO:0005096 GTPase activator activity 50/2058 271/18639 0.18450184501845 1.67100577711316 0.000184686823050509 0.00854347562926246 GO:0019955 cytokine binding 31/2058 144/18639 0.215277777777778 1.94973882410107 0.000193793899610828 0.00864459216478302 GO:0001965 G-protein alpha-subunit binding 11/2058 30/18639 0.366666666666667 3.32084548104956 0.000214241807079324 0.00922717300145089 GO:0032395 MHC class II receptor activity 6/2058 10/18639 0.6 5.43411078717201 0.000254611250876638 0.010600315078164 GO:0019838 growth factor binding 29/2058 136/18639 0.213235294117647 1.93124035328417 0.000363111409919215 0.0141726922184094 GO:0044325 transmembrane transporter binding 29/2058 136/18639 0.213235294117647 1.93124035328417 0.000363111409919215 0.0141726922184094 GO:0008081 phosphoric diester hydrolase activity 21/2058 87/18639 0.241379310344828 2.18613652357495 0.00040655103090545 0.0153873405333608 GO:0061134 peptidase regulator activity 42/2058 226/18639 0.185840707964602 1.68313165974354 0.000497424563686844 0.0181188102190392 GO:0097493 structural molecule activity conferring elasticity 6/2058 11/18639 0.545454545454545 4.94010071561092 0.000507732872431042 0.0181188102190392 GO:0038024 cargo receptor activity 17/2058 65/18639 0.261538461538462 2.36871495851088 0.000525632038872081 0.0182365115708675 GO:0004629 phospholipase C activity 10/2058 29/18639 0.344827586206897 3.12305217653564 0.000728667467271259 0.0245974504492379 GO:0050840 extracellular matrix binding 17/2058 67/18639 0.253731343283582 2.2980070493016 0.000766116584808129 0.0251810424848777 GO:0004222 metalloendopeptidase activity 24/2058 110/18639 0.218181818181818 1.97604028624437 0.000797710860630281 0.0255472016648005 GO:0008009 chemokine activity 13/2058 45/18639 0.288888888888889 2.61642371234208 0.000848665314711732 0.0264995744518738 GO:0008237 metallopeptidase activity 35/2058 184/18639 0.190217391304348 1.72277062999113 0.000914902165897396 0.0267422589068109 GO:0008179 adenylate cyclase binding 6/2058 12/18639 0.5 4.52842565597668 0.000920670242588365 0.0267422589068109 GO:0031543 peptidyl-proline dioxygenase activity 6/2058 12/18639 0.5 4.52842565597668 0.000920670242588365 0.0267422589068109 GO:0008013 beta-catenin binding 23/2058 106/18639 0.216981132075472 1.96516585070686 0.00109844278976757 0.0305344048585613 GO:0003725 double-stranded RNA binding 18/2058 75/18639 0.24 2.1736443148688 0.00110011866984408 0.0305344048585613 GO:0051010 microtubule plus-end binding 8/2058 21/18639 0.380952380952381 3.45022907122032 0.0011789320982663 0.0320105693637958 GO:0003774 cytoskeletal motor activity 30/2058 153/18639 0.196078431372549 1.77585319842223 0.0012469494169031 0.0321528868848298 GO:0004435 phosphatidylinositol phospholipase C activity 9/2058 26/18639 0.346153846153846 3.13506391567616 0.00129769635330039 0.0321528868848298 GO:0043548 phosphatidylinositol 3-kinase binding 9/2058 26/18639 0.346153846153846 3.13506391567616 0.00129769635330039 0.0321528868848298 GO:0050750 low-density lipoprotein particle receptor binding 9/2058 26/18639 0.346153846153846 3.13506391567616 0.00129769635330039 0.0321528868848298 GO:0070325 lipoprotein particle receptor binding 10/2058 31/18639 0.32258064516129 2.92156493933979 0.00131288809537736 0.0321528868848298 GO:0008569 minus-end-directed microtubule motor activity 7/2058 17/18639 0.411764705882353 3.72929171668667 0.00141200767745945 0.0337482833131836 GO:0005496 steroid binding 23/2058 108/18639 0.212962962962963 1.92877389050858 0.0014320728707756 0.0337482833131836 GO:0001540 amyloid-beta binding 19/2058 83/18639 0.228915662650602 2.07325511960378 0.00148520546886219 0.0343522524186828 GO:0001664 G protein-coupled receptor binding 50/2058 297/18639 0.168350168350168 1.52472244308979 0.00158216100483482 0.0359294380916125 GO:0005044 scavenger receptor activity 9/2058 27/18639 0.333333333333333 3.01895043731778 0.00175786214040548 0.038582657616764 GO:0002020 protease binding 27/2058 136/18639 0.198529411764706 1.7980513634025 0.00176189268539722 0.038582657616764 GO:0061135 endopeptidase regulator activity 34/2058 184/18639 0.184782608695652 1.67354861199138 0.00179166864833652 0.038582657616764 GO:1990782 protein tyrosine kinase binding 24/2058 117/18639 0.205128205128205 1.85781565373402 0.00195654258521414 0.0414190116768214 GO:0031690 adrenergic receptor binding 7/2058 18/18639 0.388888888888889 3.52210884353741 0.00209199026205644 0.0435482639551416 GO:0051959 dynein light intermediate chain binding 9/2058 28/18639 0.321428571428571 2.91113077884215 0.00233979173919061 0.0471679580340908 GO:0070851 growth factor receptor binding 27/2058 139/18639 0.194244604316547 1.75924449944418 0.00244424404891926 0.0471679580340908 GO:0005161 platelet-derived growth factor receptor binding 6/2058 14/18639 0.428571428571429 3.88150770512287 0.00246141329231203 0.0471679580340908 GO:0008191 metalloendopeptidase inhibitor activity 6/2058 14/18639 0.428571428571429 3.88150770512287 0.00246141329231203 0.0471679580340908 GO:0019992 diacylglycerol binding 6/2058 14/18639 0.428571428571429 3.88150770512287 0.00246141329231203 0.0471679580340908 GO:0032934 sterol binding 16/2058 68/18639 0.235294117647059 2.13102383810667 0.00252617263862781 0.0471679580340908 GO:0051015 actin filament binding 37/2058 209/18639 0.177033492822967 1.60336602173337 0.00253022673201288 0.0471679580340908 GO:0015085 calcium ion transmembrane transporter activity 28/2058 147/18639 0.19047619047619 1.72511453561016 0.00276619148002102 0.0508084288021508 GO:0140303 intramembrane lipid transporter activity 12/2058 45/18639 0.266666666666667 2.41516034985423 0.00281457381091858 0.0509478650701059 GO:0042562 hormone binding 20/2058 94/18639 0.212765957446809 1.92698964084114 0.00286725916087683 0.0511600955990736 GO:0043395 heparan sulfate proteoglycan binding 7/2058 19/18639 0.368421052631579 3.33673469387755 0.0029996196665008 0.0520350689369374 GO:0046624 sphingolipid transporter activity 7/2058 19/18639 0.368421052631579 3.33673469387755 0.0029996196665008 0.0520350689369374 GO:0099604 ligand-gated calcium channel activity 9/2058 29/18639 0.310344827586207 2.81074695888208 0.00306479766155431 0.052437428483306 GO:0005125 cytokine activity 40/2058 234/18639 0.170940170940171 1.54817971144502 0.00333497578744669 0.0562889832232557 GO:0097110 scaffold protein binding 16/2058 70/18639 0.228571428571429 2.07013744273219 0.00344967698079742 0.0574486206535464 GO:0005154 epidermal growth factor receptor binding 10/2058 35/18639 0.285714285714286 2.58767180341524 0.00360392974015231 0.0592277400717136 GO:0016004 phospholipase activator activity 7/2058 20/18639 0.35 3.16989795918367 0.00418003658975344 0.0669341756487441 GO:0042288 MHC class I protein binding 7/2058 20/18639 0.35 3.16989795918367 0.00418003658975344 0.0669341756487441 GO:0034056 estrogen response element binding 5/2058 11/18639 0.454545454545455 4.11675059634243 0.00425454111952828 0.067264833649251 GO:0005262 calcium channel activity 25/2058 131/18639 0.190839694656489 1.7284067389224 0.00440299106268294 0.0687416979661373 GO:0042379 chemokine receptor binding 16/2058 72/18639 0.222222222222222 2.01263362487852 0.00463447016260769 0.0714623855937901 GO:0042056 chemoattractant activity 11/2058 42/18639 0.261904761904762 2.37203248646397 0.00483530388963952 0.0736499336360947 GO:0015485 cholesterol binding 13/2058 54/18639 0.240740740740741 2.1803530936184 0.00502135726159476 0.0755623520449621 GO:0140328 floppase activity 6/2058 16/18639 0.375 3.39631924198251 0.00540492685513453 0.0796179350605362 GO:0004866 endopeptidase inhibitor activity 29/2058 161/18639 0.180124223602484 1.63135831084874 0.00541835426753049 0.0796179350605362 GO:0008373 sialyltransferase activity 7/2058 21/18639 0.333333333333333 3.01895043731778 0.00568058883549698 0.0825006448318108 GO:0030414 peptidase inhibitor activity 30/2058 169/18639 0.177514792899408 1.60772508496213 0.00586827899811581 0.0842469019384672 GO:0001618 virus receptor activity 17/2058 81/18639 0.209876543209877 1.9008206457186 0.00658909212308638 0.0931259657054984 GO:0070679 inositol 1,4,5 trisphosphate binding 5/2058 12/18639 0.416666666666667 3.77368804664723 0.00663587746019965 0.0931259657054984 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 8/2058 27/18639 0.296296296296296 2.68351149983803 0.00704121516118046 0.0970956939410014 GO:0048020 CCR chemokine receptor binding 12/2058 50/18639 0.24 2.1736443148688 0.0070742258996246 0.0970956939410014 GO:0005085 guanyl-nucleotide exchange factor activity 38/2058 230/18639 0.165217391304348 1.49634934719229 0.00733810306276329 0.099622725275993 GO:0140272 exogenous protein binding 17/2058 82/18639 0.207317073170732 1.87763990613667 0.00747838112882449 0.100435462687116 GO:0004029 aldehyde dehydrogenase (NAD+) activity 6/2058 17/18639 0.352941176470588 3.19653575716001 0.00758288277023004 0.100755538085291 GO:0004857 enzyme inhibitor activity 62/2058 416/18639 0.149038461538462 1.34981918591612 0.00872016918982136 0.114647277032493 GO:0097718 disordered domain specific binding 8/2058 28/18639 0.285714285714286 2.58767180341524 0.00892178452997643 0.116076134145214 GO:0099106 ion channel regulator activity 28/2058 160/18639 0.175 1.58494897959184 0.00920059638378218 0.118469534879835 GO:0015035 protein-disulfide reductase activity 9/2058 34/18639 0.264705882352941 2.39740181787 0.00967967490620482 0.122865601673767 GO:0005080 protein kinase C binding 12/2058 52/18639 0.230769230769231 2.09004261045077 0.00978210678166476 0.122865601673767 GO:0031681 G-protein beta-subunit binding 7/2058 23/18639 0.304347826086957 2.7564330079858 0.00983711782816386 0.122865601673767 GO:0015036 disulfide oxidoreductase activity 10/2058 40/18639 0.25 2.26421282798834 0.00999166561267443 0.12356030049733 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 6/2058 18/18639 0.333333333333333 3.01895043731778 0.0103283290243168 0.126471401484037 GO:0004879 nuclear receptor activity 13/2058 59/18639 0.220338983050847 1.99557740771854 0.0109068522580737 0.132258820100331 GO:0005246 calcium channel regulator activity 12/2058 53/18639 0.226415094339623 2.05060784421585 0.0114066768272596 0.135685136735688 GO:0017046 peptide hormone binding 12/2058 53/18639 0.226415094339623 2.05060784421585 0.0114066768272596 0.135685136735688 GO:0046332 SMAD binding 16/2058 79/18639 0.20253164556962 1.83429899988929 0.0116171687860562 0.136745027906545 GO:0001784 phosphotyrosine residue binding 11/2058 47/18639 0.234042553191489 2.11968860492525 0.0117763339794632 0.136745027906545 GO:0005126 cytokine receptor binding 43/2058 275/18639 0.156363636363636 1.4161622051418 0.011928818002352 0.136745027906545 GO:0042287 MHC protein binding 10/2058 41/18639 0.24390243902439 2.20898812486667 0.0119385567210449 0.136745027906545 GO:0005319 lipid transporter activity 30/2058 178/18639 0.168539325842697 1.52643561437416 0.0121531991652056 0.136745027906545 GO:0098531 ligand-modulated transcription factor activity 13/2058 60/18639 0.216666666666667 1.96231778425656 0.0125535267732909 0.136745027906545 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 7/2058 24/18639 0.291666666666667 2.64158163265306 0.0125906150594497 0.136745027906545 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 7/2058 24/18639 0.291666666666667 2.64158163265306 0.0125906150594497 0.136745027906545 GO:0060229 lipase activator activity 7/2058 24/18639 0.291666666666667 2.64158163265306 0.0125906150594497 0.136745027906545 GO:0070840 dynein complex binding 7/2058 24/18639 0.291666666666667 2.64158163265306 0.0125906150594497 0.136745027906545 GO:0048306 calcium-dependent protein binding 16/2058 80/18639 0.2 1.81137026239067 0.013074640356794 0.140777808669273 GO:0016887 ATP hydrolysis activity 61/2058 417/18639 0.146282973621103 1.32486314155673 0.01345464462911 0.143631206339815 GO:0032036 myosin heavy chain binding 5/2058 14/18639 0.357142857142857 3.23458975426905 0.0138990638681752 0.144465932694971 GO:0042043 neurexin family protein binding 5/2058 14/18639 0.357142857142857 3.23458975426905 0.0138990638681752 0.144465932694971 GO:1990825 sequence-specific mRNA binding 5/2058 14/18639 0.357142857142857 3.23458975426905 0.0138990638681752 0.144465932694971 GO:0001221 transcription coregulator binding 21/2058 115/18639 0.182608695652174 1.65385980479148 0.0139954986838202 0.144465932694971 GO:0016298 lipase activity 23/2058 130/18639 0.176923076923077 1.60236600134559 0.015088608842868 0.154472724956903 GO:0044183 protein folding chaperone 15/2058 75/18639 0.2 1.81137026239067 0.015941298646555 0.161875463492253 GO:0048156 tau protein binding 10/2058 43/18639 0.232558139534884 2.10624449115194 0.0166723593343988 0.167933683940839 GO:0042805 actinin binding 9/2058 37/18639 0.243243243243243 2.20301788669136 0.0169844674084841 0.169708798345573 GO:0016247 channel regulator activity 28/2058 168/18639 0.166666666666667 1.50947521865889 0.0172750998709086 0.171242855069562 GO:0031418 L-ascorbic acid binding 6/2058 20/18639 0.3 2.71705539358601 0.0177954275563711 0.172917980464682 GO:0005031 tumor necrosis factor receptor activity 4/2058 10/18639 0.4 3.62274052478134 0.0179978682629373 0.172917980464682 GO:0008239 dipeptidyl-peptidase activity 4/2058 10/18639 0.4 3.62274052478134 0.0179978682629373 0.172917980464682 GO:0031957 very long-chain fatty acid-CoA ligase activity 4/2058 10/18639 0.4 3.62274052478134 0.0179978682629373 0.172917980464682 GO:0031005 filamin binding 5/2058 15/18639 0.333333333333333 3.01895043731778 0.0189875134075901 0.179662153379394 GO:0051371 muscle alpha-actinin binding 5/2058 15/18639 0.333333333333333 3.01895043731778 0.0189875134075901 0.179662153379394 GO:0004112 cyclic-nucleotide phosphodiesterase activity 7/2058 26/18639 0.269230769230769 2.4383830455259 0.0196822600325279 0.184835660004717 GO:0141108 transporter regulator activity 28/2058 170/18639 0.164705882352941 1.49171668667467 0.0199878986259515 0.186305114804578 GO:0042910 xenobiotic transmembrane transporter activity 8/2058 32/18639 0.25 2.26421282798834 0.0202992399950884 0.187805561139744 GO:0008236 serine-type peptidase activity 31/2058 194/18639 0.15979381443299 1.44722881788945 0.0222549002174793 0.204385076261998 GO:0008142 oxysterol binding 5/2058 16/18639 0.3125 2.83026603498542 0.025161416385979 0.221231469468423 GO:0015562 efflux transmembrane transporter activity 5/2058 16/18639 0.3125 2.83026603498542 0.025161416385979 0.221231469468423 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 5/2058 16/18639 0.3125 2.83026603498542 0.025161416385979 0.221231469468423 GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 5/2058 16/18639 0.3125 2.83026603498542 0.025161416385979 0.221231469468423 GO:0140327 flippase activity 5/2058 16/18639 0.3125 2.83026603498542 0.025161416385979 0.221231469468423 GO:0002162 dystroglycan binding 4/2058 11/18639 0.363636363636364 3.29340047707395 0.0258511980591711 0.221231469468423 GO:0010854 adenylate cyclase regulator activity 4/2058 11/18639 0.363636363636364 3.29340047707395 0.0258511980591711 0.221231469468423 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 4/2058 11/18639 0.363636363636364 3.29340047707395 0.0258511980591711 0.221231469468423 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 4/2058 11/18639 0.363636363636364 3.29340047707395 0.0258511980591711 0.221231469468423 GO:0045309 protein phosphorylated amino acid binding 12/2058 59/18639 0.203389830508475 1.84207145327865 0.0258605240531544 0.221231469468423 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 9/2058 40/18639 0.225 2.0377915451895 0.027663811891143 0.233460142243497 GO:0030331 nuclear estrogen receptor binding 9/2058 40/18639 0.225 2.0377915451895 0.027663811891143 0.233460142243497 GO:0015079 potassium ion transmembrane transporter activity 26/2058 160/18639 0.1625 1.47173833819242 0.0282614187630711 0.236902765336079 GO:0017171 serine hydrolase activity 31/2058 198/18639 0.156565656565657 1.4179918720735 0.0287318104156741 0.23924020806118 GO:0050698 proteoglycan sulfotransferase activity 7/2058 28/18639 0.25 2.26421282798834 0.0291682394733404 0.239279816979401 GO:0051393 alpha-actinin binding 7/2058 28/18639 0.25 2.26421282798834 0.0291682394733404 0.239279816979401 GO:0004620 phospholipase activity 19/2058 109/18639 0.174311926605505 1.57871720116618 0.0293112986371885 0.239279816979401 GO:0008238 exopeptidase activity 18/2058 102/18639 0.176470588235294 1.59826787858 0.0297982291844722 0.24010609694823 GO:0042578 phosphoric ester hydrolase activity 52/2058 363/18639 0.143250688705234 1.29740018793822 0.0299780636278589 0.24010609694823 GO:0140359 ABC-type transporter activity 10/2058 47/18639 0.212765957446809 1.92698964084114 0.0300824501440599 0.24010609694823 GO:0004867 serine-type endopeptidase inhibitor activity 17/2058 95/18639 0.178947368421053 1.62069970845481 0.0301814709534604 0.24010609694823 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 11/2058 54/18639 0.203703703703704 1.84491415613865 0.0317421144079087 0.24740713984929 GO:0051287 NAD binding 11/2058 54/18639 0.203703703703704 1.84491415613865 0.0317421144079087 0.24740713984929 GO:0042169 SH2 domain binding 9/2058 41/18639 0.219512195121951 1.98808931238 0.0320865399077331 0.24740713984929 GO:0008083 growth factor activity 26/2058 162/18639 0.160493827160494 1.45356872907893 0.0324209535482275 0.24740713984929 GO:0015278 intracellularly gated calcium channel activity 5/2058 17/18639 0.294117647058824 2.66377979763334 0.0324858053925409 0.24740713984929 GO:0017110 nucleoside diphosphate phosphatase activity 5/2058 17/18639 0.294117647058824 2.66377979763334 0.0324858053925409 0.24740713984929 GO:0051787 misfolded protein binding 5/2058 17/18639 0.294117647058824 2.66377979763334 0.0324858053925409 0.24740713984929 GO:0004896 cytokine receptor activity 17/2058 96/18639 0.177083333333333 1.60381741982507 0.0330385239097365 0.248678115337797 GO:0005548 phospholipid transporter activity 13/2058 68/18639 0.191176470588235 1.73145686846167 0.0334251367686554 0.248678115337797 GO:1990841 promoter-specific chromatin binding 13/2058 68/18639 0.191176470588235 1.73145686846167 0.0334251367686554 0.248678115337797 GO:0004713 protein tyrosine kinase activity 23/2058 140/18639 0.164285714285714 1.48791128696377 0.0334490979797838 0.248678115337797 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 6/2058 23/18639 0.260869565217391 2.36265686398783 0.0348171882266126 0.254308000555785 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 6/2058 23/18639 0.260869565217391 2.36265686398783 0.0348171882266126 0.254308000555785 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 6/2058 23/18639 0.260869565217391 2.36265686398783 0.0348171882266126 0.254308000555785 GO:0045295 gamma-catenin binding 4/2058 12/18639 0.333333333333333 3.01895043731778 0.0354588583586567 0.257489035406757 GO:0005543 phospholipid binding 68/2058 497/18639 0.13682092555332 1.23916677910026 0.0364054332748444 0.262834602082547 GO:0001222 transcription corepressor binding 10/2058 49/18639 0.204081632653061 1.84833700243946 0.0390639682638001 0.28040745035337 GO:0045505 dynein intermediate chain binding 8/2058 36/18639 0.222222222222222 2.01263362487852 0.0393965974736106 0.281179144254512 GO:0072341 modified amino acid binding 16/2058 91/18639 0.175824175824176 1.5924134174863 0.0400828117643372 0.284451317577598 GO:0005244 voltage-gated monoatomic ion channel activity 27/2058 173/18639 0.15606936416185 1.41349702556497 0.0404745882873796 0.285208611675846 GO:0008525 phosphatidylcholine transporter activity 5/2058 18/18639 0.277777777777778 2.51579203109815 0.0410079116880117 0.285208611675846 GO:1901611 phosphatidylglycerol binding 5/2058 18/18639 0.277777777777778 2.51579203109815 0.0410079116880117 0.285208611675846 GO:0001968 fibronectin binding 7/2058 30/18639 0.233333333333333 2.11326530612245 0.0413312719882531 0.285208611675846 GO:0048019 receptor antagonist activity 7/2058 30/18639 0.233333333333333 2.11326530612245 0.0413312719882531 0.285208611675846 GO:0030552 cAMP binding 6/2058 24/18639 0.25 2.26421282798834 0.0422260459490003 0.285923516146952 GO:0035035 histone acetyltransferase binding 6/2058 24/18639 0.25 2.26421282798834 0.0422260459490003 0.285923516146952 GO:0050431 transforming growth factor beta binding 6/2058 24/18639 0.25 2.26421282798834 0.0422260459490003 0.285923516146952 GO:0008375 acetylglucosaminyltransferase activity 9/2058 43/18639 0.209302325581395 1.89562004203675 0.0423505608384197 0.285923516146952 GO:0004175 endopeptidase activity 56/2058 405/18639 0.138271604938272 1.25230536659108 0.0451816625797289 0.294089222005366 GO:0016504 peptidase activator activity 11/2058 57/18639 0.192982456140351 1.74781341107872 0.0451907579176035 0.294089222005366 GO:0022832 voltage-gated channel activity 27/2058 175/18639 0.154285714285714 1.39734277384423 0.0457605394578286 0.294089222005366 GO:0016922 nuclear receptor binding 22/2058 137/18639 0.160583941605839 1.45438488221149 0.0459225986441548 0.294089222005366 GO:0005261 monoatomic cation channel activity 48/2058 341/18639 0.140762463343109 1.27486470080282 0.0464412370553502 0.294089222005366 GO:0005035 death receptor activity 4/2058 13/18639 0.307692307692308 2.78672348060103 0.0468564893347221 0.294089222005366 GO:0005542 folic acid binding 4/2058 13/18639 0.307692307692308 2.78672348060103 0.0468564893347221 0.294089222005366 GO:0017154 semaphorin receptor activity 4/2058 13/18639 0.307692307692308 2.78672348060103 0.0468564893347221 0.294089222005366 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 4/2058 13/18639 0.307692307692308 2.78672348060103 0.0468564893347221 0.294089222005366 GO:0061459 L-arginine transmembrane transporter activity 4/2058 13/18639 0.307692307692308 2.78672348060103 0.0468564893347221 0.294089222005366 GO:0071837 HMG box domain binding 4/2058 13/18639 0.307692307692308 2.78672348060103 0.0468564893347221 0.294089222005366 GO:0140333 glycerophospholipid flippase activity 4/2058 13/18639 0.307692307692308 2.78672348060103 0.0468564893347221 0.294089222005366 GO:0140410 monoatomic cation:bicarbonate symporter activity 4/2058 13/18639 0.307692307692308 2.78672348060103 0.0468564893347221 0.294089222005366 GO:0140852 histone ubiquitin ligase activity 4/2058 13/18639 0.307692307692308 2.78672348060103 0.0468564893347221 0.294089222005366 GO:0001223 transcription coactivator binding 9/2058 44/18639 0.204545454545455 1.85253776835409 0.0482259792119307 0.297630698240989 GO:0019205 nucleobase-containing compound kinase activity 9/2058 44/18639 0.204545454545455 1.85253776835409 0.0482259792119307 0.297630698240989 GO:0030547 signaling receptor inhibitor activity 9/2058 44/18639 0.204545454545455 1.85253776835409 0.0482259792119307 0.297630698240989 GO:0017147 Wnt-protein binding 7/2058 31/18639 0.225806451612903 2.04509545753785 0.0484839343381639 0.297630698240989 GO:0022836 gated channel activity 45/2058 318/18639 0.141509433962264 1.28162990263491 0.048707837459638 0.297630698240989 GO:0005021 vascular endothelial growth factor receptor activity 10/2058 51/18639 0.196078431372549 1.77585319842223 0.0497348004881385 0.297630698240989 GO:0008483 transaminase activity 6/2058 25/18639 0.24 2.1736443148688 0.0505529748573276 0.297630698240989 GO:0003756 protein disulfide isomerase activity 5/2058 19/18639 0.263157894736842 2.38338192419825 0.0507568764814497 0.297630698240989 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 5/2058 19/18639 0.263157894736842 2.38338192419825 0.0507568764814497 0.297630698240989 GO:0005229 intracellularly calcium-gated chloride channel activity 5/2058 19/18639 0.263157894736842 2.38338192419825 0.0507568764814497 0.297630698240989 GO:0008574 plus-end-directed microtubule motor activity 5/2058 19/18639 0.263157894736842 2.38338192419825 0.0507568764814497 0.297630698240989 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 5/2058 19/18639 0.263157894736842 2.38338192419825 0.0507568764814497 0.297630698240989 GO:0050145 nucleoside monophosphate kinase activity 5/2058 19/18639 0.263157894736842 2.38338192419825 0.0507568764814497 0.297630698240989 GO:0141147 intracellularly calcium-gated channel activity 5/2058 19/18639 0.263157894736842 2.38338192419825 0.0507568764814497 0.297630698240989 GO:0005501 retinoid binding 8/2058 38/18639 0.210526315789474 1.9067055393586 0.0523642005849555 0.304199472235393 GO:0019840 isoprenoid binding 8/2058 38/18639 0.210526315789474 1.9067055393586 0.0523642005849555 0.304199472235393 GO:0001216 DNA-binding transcription activator activity 66/2058 491/18639 0.134419551934827 1.21741789529312 0.0526574933982958 0.304487079881812 GO:0005267 potassium channel activity 20/2058 124/18639 0.161290322580645 1.4607824696699 0.0529547757744247 0.304794999733901 GO:0004715 non-membrane spanning protein tyrosine kinase activity 9/2058 45/18639 0.2 1.81137026239067 0.0546157578052755 0.312913217884354 GO:0001786 phosphatidylserine binding 11/2058 59/18639 0.186440677966102 1.68856549883876 0.0560564216422925 0.318247593778288 GO:0015459 potassium channel regulator activity 11/2058 59/18639 0.186440677966102 1.68856549883876 0.0560564216422925 0.318247593778288 GO:0030971 receptor tyrosine kinase binding 14/2058 81/18639 0.172839506172839 1.56538170823885 0.0591615455325448 0.32890037255331 GO:0008066 glutamate receptor activity 6/2058 26/18639 0.230769230769231 2.09004261045077 0.0598141893047676 0.32890037255331 GO:0052742 phosphatidylinositol kinase activity 6/2058 26/18639 0.230769230769231 2.09004261045077 0.0598141893047676 0.32890037255331 GO:0070006 metalloaminopeptidase activity 6/2058 26/18639 0.230769230769231 2.09004261045077 0.0598141893047676 0.32890037255331 GO:0008195 phosphatidate phosphatase activity 4/2058 14/18639 0.285714285714286 2.58767180341524 0.0600394595213408 0.32890037255331 GO:0008331 high voltage-gated calcium channel activity 4/2058 14/18639 0.285714285714286 2.58767180341524 0.0600394595213408 0.32890037255331 GO:0008559 ABC-type xenobiotic transporter activity 4/2058 14/18639 0.285714285714286 2.58767180341524 0.0600394595213408 0.32890037255331 GO:0031404 chloride ion binding 4/2058 14/18639 0.285714285714286 2.58767180341524 0.0600394595213408 0.32890037255331 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 9/2058 46/18639 0.195652173913043 1.77199264799087 0.0615307316957344 0.334817230919898 GO:0010851 cyclase regulator activity 5/2058 20/18639 0.25 2.26421282798834 0.0617440261231426 0.334817230919898 GO:0008146 sulfotransferase activity 10/2058 53/18639 0.188679245283019 1.70883987017988 0.0621918315239521 0.334817230919898 GO:0051018 protein kinase A binding 10/2058 53/18639 0.188679245283019 1.70883987017988 0.0621918315239521 0.334817230919898 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 48/2058 349/18639 0.137535816618911 1.24564144118556 0.0643074735466581 0.344721177938953 GO:0019956 chemokine binding 7/2058 33/18639 0.212121212121212 1.92115027829314 0.06501790324884 0.345142915677562 GO:0071889 14-3-3 protein binding 7/2058 33/18639 0.212121212121212 1.92115027829314 0.06501790324884 0.345142915677562 GO:0043177 organic acid binding 28/2058 189/18639 0.148148148148148 1.34175574991902 0.0652151546036066 0.345142915677562 GO:0022843 voltage-gated monoatomic cation channel activity 22/2058 143/18639 0.153846153846154 1.39336174030052 0.0678264453808528 0.357448229032427 GO:0046873 metal ion transmembrane transporter activity 60/2058 450/18639 0.133333333333333 1.20758017492711 0.070289743345692 0.368873485036846 GO:0017022 myosin binding 13/2058 76/18639 0.171052631578947 1.54919825072886 0.0719891114173952 0.371564811380952 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 64/2058 484/18639 0.132231404958678 1.19760017348143 0.0722590357907217 0.371564811380952 GO:0035591 signaling adaptor activity 20/2058 129/18639 0.155038759689922 1.40416299410129 0.0739448797256212 0.371564811380952 GO:0001846 opsonin binding 5/2058 21/18639 0.238095238095238 2.1563931695127 0.0739636083351493 0.371564811380952 GO:0009931 calcium-dependent protein serine/threonine kinase activity 5/2058 21/18639 0.238095238095238 2.1563931695127 0.0739636083351493 0.371564811380952 GO:0036122 BMP binding 5/2058 21/18639 0.238095238095238 2.1563931695127 0.0739636083351493 0.371564811380952 GO:0061891 calcium ion sensor activity 5/2058 21/18639 0.238095238095238 2.1563931695127 0.0739636083351493 0.371564811380952 GO:0070182 DNA polymerase binding 5/2058 21/18639 0.238095238095238 2.1563931695127 0.0739636083351493 0.371564811380952 GO:0008376 acetylgalactosaminyltransferase activity 7/2058 34/18639 0.205882352941176 1.86464585834334 0.0744162917898235 0.371564811380952 GO:0090482 vitamin transmembrane transporter activity 7/2058 34/18639 0.205882352941176 1.86464585834334 0.0744162917898235 0.371564811380952 GO:0004467 long-chain fatty acid-CoA ligase activity 4/2058 15/18639 0.266666666666667 2.41516034985423 0.0749674399263411 0.371564811380952 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 4/2058 15/18639 0.266666666666667 2.41516034985423 0.0749674399263411 0.371564811380952 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 4/2058 15/18639 0.266666666666667 2.41516034985423 0.0749674399263411 0.371564811380952 GO:0005523 tropomyosin binding 4/2058 15/18639 0.266666666666667 2.41516034985423 0.0749674399263411 0.371564811380952 GO:0030246 carbohydrate binding 39/2058 280/18639 0.139285714285714 1.26149000416493 0.0758252785075267 0.373250844922746 GO:0001727 lipid kinase activity 8/2058 41/18639 0.195121951219512 1.76719049989334 0.0764451616935205 0.373250844922746 GO:0016877 ligase activity, forming carbon-sulfur bonds 8/2058 41/18639 0.195121951219512 1.76719049989334 0.0764451616935205 0.373250844922746 GO:0008194 UDP-glycosyltransferase activity 22/2058 145/18639 0.151724137931034 1.37414295767568 0.0765029754205148 0.373250844922746 GO:0140693 molecular condensate scaffold activity 9/2058 48/18639 0.1875 1.69815962099125 0.0769658904208139 0.374048237881698 GO:0035401 histone H3Y41 kinase activity 18/2058 115/18639 0.156521739130435 1.4175941183927 0.0805693089707912 0.388536937855283 GO:0140801 histone H2AXY142 kinase activity 18/2058 115/18639 0.156521739130435 1.4175941183927 0.0805693089707912 0.388536937855283 GO:0005242 inward rectifier potassium channel activity 6/2058 28/18639 0.214285714285714 1.94075385256143 0.0811567441923453 0.389864513447074 GO:0019199 transmembrane receptor protein kinase activity 13/2058 78/18639 0.166666666666667 1.50947521865889 0.0848874700106364 0.390870943386542 GO:0005004 GPI-linked ephrin receptor activity 9/2058 49/18639 0.183673469387755 1.66350330219551 0.085493822906142 0.390870943386542 GO:0005008 hepatocyte growth factor receptor activity 9/2058 49/18639 0.183673469387755 1.66350330219551 0.085493822906142 0.390870943386542 GO:0005009 insulin receptor activity 9/2058 49/18639 0.183673469387755 1.66350330219551 0.085493822906142 0.390870943386542 GO:0005011 macrophage colony-stimulating factor receptor activity 9/2058 49/18639 0.183673469387755 1.66350330219551 0.085493822906142 0.390870943386542 GO:0005018 platelet-derived growth factor alpha-receptor activity 9/2058 49/18639 0.183673469387755 1.66350330219551 0.085493822906142 0.390870943386542 GO:0005020 stem cell factor receptor activity 9/2058 49/18639 0.183673469387755 1.66350330219551 0.085493822906142 0.390870943386542 GO:0008288 boss receptor activity 9/2058 49/18639 0.183673469387755 1.66350330219551 0.085493822906142 0.390870943386542 GO:0016763 pentosyltransferase activity 9/2058 49/18639 0.183673469387755 1.66350330219551 0.085493822906142 0.390870943386542 GO:0036332 placental growth factor receptor activity 9/2058 49/18639 0.183673469387755 1.66350330219551 0.085493822906142 0.390870943386542 GO:0038062 protein tyrosine kinase collagen receptor activity 9/2058 49/18639 0.183673469387755 1.66350330219551 0.085493822906142 0.390870943386542 GO:0060175 brain-derived neurotrophic factor receptor activity 9/2058 49/18639 0.183673469387755 1.66350330219551 0.085493822906142 0.390870943386542 GO:0016757 glycosyltransferase activity 37/2058 267/18639 0.138576779026217 1.25506928292987 0.0866925560222504 0.390870943386542 GO:0140784 metal ion sensor activity 5/2058 22/18639 0.227272727272727 2.05837529817122 0.0873938907505847 0.390870943386542 GO:0031406 carboxylic acid binding 27/2058 187/18639 0.144385026737968 1.30767371883818 0.0884072404369775 0.390870943386542 GO:0004382 GDP phosphatase activity 3/2058 10/18639 0.3 2.71705539358601 0.0891899270337587 0.390870943386542 GO:0004862 cAMP-dependent protein kinase inhibitor activity 3/2058 10/18639 0.3 2.71705539358601 0.0891899270337587 0.390870943386542 GO:0004955 prostaglandin receptor activity 3/2058 10/18639 0.3 2.71705539358601 0.0891899270337587 0.390870943386542 GO:0005522 profilin binding 3/2058 10/18639 0.3 2.71705539358601 0.0891899270337587 0.390870943386542 GO:0015279 store-operated calcium channel activity 3/2058 10/18639 0.3 2.71705539358601 0.0891899270337587 0.390870943386542 GO:0016175 superoxide-generating NAD(P)H oxidase activity 3/2058 10/18639 0.3 2.71705539358601 0.0891899270337587 0.390870943386542 GO:0016303 1-phosphatidylinositol-3-kinase activity 3/2058 10/18639 0.3 2.71705539358601 0.0891899270337587 0.390870943386542 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 3/2058 10/18639 0.3 2.71705539358601 0.0891899270337587 0.390870943386542 GO:0070739 protein-glutamic acid ligase activity 3/2058 10/18639 0.3 2.71705539358601 0.0891899270337587 0.390870943386542 GO:0070740 tubulin-glutamic acid ligase activity 3/2058 10/18639 0.3 2.71705539358601 0.0891899270337587 0.390870943386542 GO:0003688 DNA replication origin binding 4/2058 16/18639 0.25 2.26421282798834 0.0915694477731284 0.398502579333231 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 4/2058 16/18639 0.25 2.26421282798834 0.0915694477731284 0.398502579333231 GO:0003785 actin monomer binding 6/2058 29/18639 0.206896551724138 1.87383130592138 0.0932236281946814 0.40429274866374 GO:0005006 epidermal growth factor receptor activity 9/2058 50/18639 0.18 1.6302332361516 0.0945623832792129 0.404480879163482 GO:0005007 fibroblast growth factor receptor activity 9/2058 50/18639 0.18 1.6302332361516 0.0945623832792129 0.404480879163482 GO:0005017 platelet-derived growth factor receptor activity 9/2058 50/18639 0.18 1.6302332361516 0.0945623832792129 0.404480879163482 GO:0005019 platelet-derived growth factor beta-receptor activity 9/2058 50/18639 0.18 1.6302332361516 0.0945623832792129 0.404480879163482 GO:0005158 insulin receptor binding 5/2058 23/18639 0.217391304347826 1.96888071998986 0.101998530340577 0.43296574947057 GO:0043274 phospholipase binding 5/2058 23/18639 0.217391304347826 1.96888071998986 0.101998530340577 0.43296574947057 GO:0003823 antigen binding 25/2058 174/18639 0.14367816091954 1.30127174022318 0.102261726256059 0.43296574947057 GO:0005010 insulin-like growth factor receptor activity 9/2058 51/18639 0.176470588235294 1.59826787858 0.1041682938773 0.438068010278612 GO:0005030 neurotrophin receptor activity 9/2058 51/18639 0.176470588235294 1.59826787858 0.1041682938773 0.438068010278612 GO:0016769 transferase activity, transferring nitrogenous groups 6/2058 30/18639 0.2 1.81137026239067 0.106196717246288 0.439453258718497 GO:0008235 metalloexopeptidase activity 11/2058 66/18639 0.166666666666667 1.50947521865889 0.106990175157702 0.439453258718497 GO:0030551 cyclic nucleotide binding 7/2058 37/18639 0.189189189189189 1.7134583563155 0.107116833549816 0.439453258718497 GO:0044389 ubiquitin-like protein ligase binding 43/2058 322/18639 0.133540372670807 1.20945529942234 0.108326176434802 0.439453258718497 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 4/2058 17/18639 0.235294117647059 2.13102383810667 0.109749030044078 0.439453258718497 GO:0046965 nuclear retinoid X receptor binding 4/2058 17/18639 0.235294117647059 2.13102383810667 0.109749030044078 0.439453258718497 GO:0070403 NAD+ binding 4/2058 17/18639 0.235294117647059 2.13102383810667 0.109749030044078 0.439453258718497 GO:1990226 histone methyltransferase binding 4/2058 17/18639 0.235294117647059 2.13102383810667 0.109749030044078 0.439453258718497 GO:0070888 E-box binding 10/2058 59/18639 0.169491525423729 1.53505954439887 0.110778963527391 0.439453258718497 GO:0003924 GTPase activity 44/2058 331/18639 0.132930513595166 1.20393189645301 0.111092628412091 0.439453258718497 GO:0048029 monosaccharide binding 12/2058 74/18639 0.162162162162162 1.46867859112757 0.111337849614007 0.439453258718497 GO:0004252 serine-type endopeptidase activity 25/2058 176/18639 0.142045454545455 1.28648456135701 0.112698968706869 0.439453258718497 GO:0004016 adenylate cyclase activity 3/2058 11/18639 0.272727272727273 2.47005035780546 0.112941950399229 0.439453258718497 GO:0004954 prostanoid receptor activity 3/2058 11/18639 0.272727272727273 2.47005035780546 0.112941950399229 0.439453258718497 GO:0005114 type II transforming growth factor beta receptor binding 3/2058 11/18639 0.272727272727273 2.47005035780546 0.112941950399229 0.439453258718497 GO:0008046 axon guidance receptor activity 3/2058 11/18639 0.272727272727273 2.47005035780546 0.112941950399229 0.439453258718497 GO:0008526 phosphatidylinositol transfer activity 3/2058 11/18639 0.272727272727273 2.47005035780546 0.112941950399229 0.439453258718497 GO:0019206 nucleoside kinase activity 3/2058 11/18639 0.272727272727273 2.47005035780546 0.112941950399229 0.439453258718497 GO:0019864 IgG binding 3/2058 11/18639 0.272727272727273 2.47005035780546 0.112941950399229 0.439453258718497 GO:0035252 UDP-xylosyltransferase activity 3/2058 11/18639 0.272727272727273 2.47005035780546 0.112941950399229 0.439453258718497 GO:0042285 xylosyltransferase activity 3/2058 11/18639 0.272727272727273 2.47005035780546 0.112941950399229 0.439453258718497 GO:0047676 arachidonate-CoA ligase activity 3/2058 11/18639 0.272727272727273 2.47005035780546 0.112941950399229 0.439453258718497 GO:0048185 activin binding 3/2058 11/18639 0.272727272727273 2.47005035780546 0.112941950399229 0.439453258718497 GO:0050998 nitric-oxide synthase binding 3/2058 11/18639 0.272727272727273 2.47005035780546 0.112941950399229 0.439453258718497 GO:0051082 unfolded protein binding 18/2058 121/18639 0.148760330578512 1.34730019516661 0.116588998156888 0.452234964900474 GO:0005109 frizzled binding 7/2058 38/18639 0.184210526315789 1.66836734693878 0.119480331316075 0.462015274965254 GO:0016878 acid-thiol ligase activity 6/2058 31/18639 0.193548387096774 1.75293896360387 0.120047785144239 0.462776801373932 GO:0004714 transmembrane receptor protein tyrosine kinase activity 10/2058 60/18639 0.166666666666667 1.50947521865889 0.120517101982122 0.463156493463601 GO:0030165 PDZ domain binding 13/2058 83/18639 0.156626506024096 1.41854297657101 0.123105666970359 0.471653306889503 GO:0005003 ephrin receptor activity 9/2058 53/18639 0.169811320754717 1.53795588316189 0.124965073717348 0.474411480464948 GO:0005005 transmembrane-ephrin receptor activity 9/2058 53/18639 0.169811320754717 1.53795588316189 0.124965073717348 0.474411480464948 GO:0038064 collagen receptor activity 9/2058 53/18639 0.169811320754717 1.53795588316189 0.124965073717348 0.474411480464948 GO:0031625 ubiquitin protein ligase binding 40/2058 302/18639 0.132450331125828 1.19958295522561 0.128428344414651 0.479546877205948 GO:0098631 cell adhesion mediator activity 12/2058 76/18639 0.157894736842105 1.43002915451895 0.128960184002002 0.479546877205948 GO:0030291 protein serine/threonine kinase inhibitor activity 8/2058 46/18639 0.173913043478261 1.57510457599189 0.129084789333893 0.479546877205948 GO:0004970 glutamate-gated receptor activity 4/2058 18/18639 0.222222222222222 2.01263362487852 0.129389349574383 0.479546877205948 GO:0017128 phospholipid scramblase activity 4/2058 18/18639 0.222222222222222 2.01263362487852 0.129389349574383 0.479546877205948 GO:0034185 apolipoprotein binding 4/2058 18/18639 0.222222222222222 2.01263362487852 0.129389349574383 0.479546877205948 GO:0050811 GABA receptor binding 4/2058 18/18639 0.222222222222222 2.01263362487852 0.129389349574383 0.479546877205948 GO:0070064 proline-rich region binding 4/2058 18/18639 0.222222222222222 2.01263362487852 0.129389349574383 0.479546877205948 GO:0051117 ATPase binding 13/2058 84/18639 0.154761904761905 1.40165556018326 0.131763888593097 0.484143268253805 GO:0003707 nuclear steroid receptor activity 5/2058 25/18639 0.2 1.81137026239067 0.134521920655987 0.484143268253805 GO:0015645 fatty acid ligase activity 5/2058 25/18639 0.2 1.81137026239067 0.134521920655987 0.484143268253805 GO:0019211 phosphatase activator activity 5/2058 25/18639 0.2 1.81137026239067 0.134521920655987 0.484143268253805 GO:0042974 nuclear retinoic acid receptor binding 5/2058 25/18639 0.2 1.81137026239067 0.134521920655987 0.484143268253805 GO:0120020 cholesterol transfer activity 5/2058 25/18639 0.2 1.81137026239067 0.134521920655987 0.484143268253805 GO:0120515 fatty acid-CoA ligase activity 5/2058 25/18639 0.2 1.81137026239067 0.134521920655987 0.484143268253805 GO:0022834 ligand-gated channel activity 26/2058 188/18639 0.138297872340426 1.25254326654674 0.134722626196481 0.484143268253805 GO:0120015 sterol transfer activity 6/2058 32/18639 0.1875 1.69815962099125 0.134741355080395 0.484143268253805 GO:0004000 adenosine deaminase activity 3/2058 12/18639 0.25 2.26421282798834 0.138769647746087 0.484143268253805 GO:0004032 aldose reductase (NADPH) activity 3/2058 12/18639 0.25 2.26421282798834 0.138769647746087 0.484143268253805 GO:0008603 cAMP-dependent protein kinase regulator activity 3/2058 12/18639 0.25 2.26421282798834 0.138769647746087 0.484143268253805 GO:0015269 calcium-activated potassium channel activity 3/2058 12/18639 0.25 2.26421282798834 0.138769647746087 0.484143268253805 GO:0015368 calcium:monoatomic cation antiporter activity 3/2058 12/18639 0.25 2.26421282798834 0.138769647746087 0.484143268253805 GO:0016208 AMP binding 3/2058 12/18639 0.25 2.26421282798834 0.138769647746087 0.484143268253805 GO:0017166 vinculin binding 3/2058 12/18639 0.25 2.26421282798834 0.138769647746087 0.484143268253805 GO:0070008 serine-type exopeptidase activity 3/2058 12/18639 0.25 2.26421282798834 0.138769647746087 0.484143268253805 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 3/2058 12/18639 0.25 2.26421282798834 0.138769647746087 0.484143268253805 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 3/2058 12/18639 0.25 2.26421282798834 0.138769647746087 0.484143268253805 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 3/2058 12/18639 0.25 2.26421282798834 0.138769647746087 0.484143268253805 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 3/2058 12/18639 0.25 2.26421282798834 0.138769647746087 0.484143268253805 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 25/2058 181/18639 0.138121546961326 1.25094631380571 0.141604028982654 0.492655799998148 GO:0005216 monoatomic ion channel activity 57/2058 448/18639 0.127232142857143 1.15232259995835 0.142015163455235 0.492713719876635 GO:0051219 phosphoprotein binding 14/2058 93/18639 0.150537634408602 1.3633969716919 0.142525855429366 0.493115771277777 GO:0004177 aminopeptidase activity 7/2058 40/18639 0.175 1.58494897959184 0.146278696631738 0.500553676967236 GO:0015144 carbohydrate transmembrane transporter activity 7/2058 40/18639 0.175 1.58494897959184 0.146278696631738 0.500553676967236 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 7/2058 40/18639 0.175 1.58494897959184 0.146278696631738 0.500553676967236 GO:0071949 FAD binding 7/2058 40/18639 0.175 1.58494897959184 0.146278696631738 0.500553676967236 GO:0019902 phosphatase binding 26/2058 190/18639 0.136842105263158 1.23935860058309 0.146755463056915 0.500813041961987 GO:0140313 molecular sequestering activity 9/2058 55/18639 0.163636363636364 1.48203021468328 0.147803180810329 0.503014094910355 GO:0005520 insulin-like growth factor binding 4/2058 19/18639 0.210526315789474 1.9067055393586 0.150358009065832 0.504600889121415 GO:0016918 retinal binding 4/2058 19/18639 0.210526315789474 1.9067055393586 0.150358009065832 0.504600889121415 GO:0022821 solute:potassium antiporter activity 4/2058 19/18639 0.210526315789474 1.9067055393586 0.150358009065832 0.504600889121415 GO:0030506 ankyrin binding 4/2058 19/18639 0.210526315789474 1.9067055393586 0.150358009065832 0.504600889121415 GO:0042577 lipid phosphatase activity 4/2058 19/18639 0.210526315789474 1.9067055393586 0.150358009065832 0.504600889121415 GO:0005227 calcium-activated cation channel activity 5/2058 26/18639 0.192307692307692 1.74170217537564 0.15230947573961 0.504600889121415 GO:0015145 monosaccharide transmembrane transporter activity 5/2058 26/18639 0.192307692307692 1.74170217537564 0.15230947573961 0.504600889121415 GO:0019865 immunoglobulin binding 5/2058 26/18639 0.192307692307692 1.74170217537564 0.15230947573961 0.504600889121415 GO:0034237 protein kinase A regulatory subunit binding 5/2058 26/18639 0.192307692307692 1.74170217537564 0.15230947573961 0.504600889121415 GO:0070412 R-SMAD binding 5/2058 26/18639 0.192307692307692 1.74170217537564 0.15230947573961 0.504600889121415 GO:0140297 DNA-binding transcription factor binding 61/2058 488/18639 0.125 1.13210641399417 0.165971155718259 0.538695703372994 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 3/2058 13/18639 0.230769230769231 2.09004261045077 0.166343595269496 0.538695703372994 GO:0005172 vascular endothelial growth factor receptor binding 3/2058 13/18639 0.230769230769231 2.09004261045077 0.166343595269496 0.538695703372994 GO:0031994 insulin-like growth factor I binding 3/2058 13/18639 0.230769230769231 2.09004261045077 0.166343595269496 0.538695703372994 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 3/2058 13/18639 0.230769230769231 2.09004261045077 0.166343595269496 0.538695703372994 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 3/2058 13/18639 0.230769230769231 2.09004261045077 0.166343595269496 0.538695703372994 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 6/2058 34/18639 0.176470588235294 1.59826787858 0.16648241913689 0.538695703372994 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 6/2058 34/18639 0.176470588235294 1.59826787858 0.16648241913689 0.538695703372994 GO:0030332 cyclin binding 6/2058 34/18639 0.176470588235294 1.59826787858 0.16648241913689 0.538695703372994 GO:0099094 ligand-gated monoatomic cation channel activity 19/2058 136/18639 0.139705882352941 1.26529540387584 0.168242694142863 0.54298481908123 GO:0008320 protein transmembrane transporter activity 5/2058 27/18639 0.185185185185185 1.67719468739877 0.171012458788615 0.547173882995302 GO:0016405 CoA-ligase activity 5/2058 27/18639 0.185185185185185 1.67719468739877 0.171012458788615 0.547173882995302 GO:0001614 purinergic nucleotide receptor activity 4/2058 20/18639 0.2 1.81137026239067 0.172511504801505 0.547173882995302 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 4/2058 20/18639 0.2 1.81137026239067 0.172511504801505 0.547173882995302 GO:0016502 nucleotide receptor activity 4/2058 20/18639 0.2 1.81137026239067 0.172511504801505 0.547173882995302 GO:0016505 peptidase activator activity involved in apoptotic process 4/2058 20/18639 0.2 1.81137026239067 0.172511504801505 0.547173882995302 GO:0008514 organic anion transmembrane transporter activity 35/2058 269/18639 0.130111524163569 1.17840072832107 0.172607293755123 0.547173882995302 GO:0015276 ligand-gated monoatomic ion channel activity 25/2058 186/18639 0.134408602150538 1.21731872472491 0.174445396910871 0.551600761371336 GO:0035198 miRNA binding 7/2058 42/18639 0.166666666666667 1.50947521865889 0.175641024808982 0.552583476036319 GO:0048487 beta-tubulin binding 7/2058 42/18639 0.166666666666667 1.50947521865889 0.175641024808982 0.552583476036319 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 13/2058 89/18639 0.146067415730337 1.32291086579094 0.17987074156122 0.563054025588882 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 13/2058 89/18639 0.146067415730337 1.32291086579094 0.17987074156122 0.563054025588882 GO:0043015 gamma-tubulin binding 6/2058 35/18639 0.171428571428571 1.55260308204915 0.183429705527934 0.572759255510975 GO:0005249 voltage-gated potassium channel activity 14/2058 98/18639 0.142857142857143 1.29383590170762 0.190083926421086 0.587635409691279 GO:0042626 ATPase-coupled transmembrane transporter activity 14/2058 98/18639 0.142857142857143 1.29383590170762 0.190083926421086 0.587635409691279 GO:0019210 kinase inhibitor activity 13/2058 90/18639 0.144444444444444 1.30821185617104 0.190400970823541 0.587635409691279 GO:0140793 histone H2AXY142 phosphatase activity 13/2058 90/18639 0.144444444444444 1.30821185617104 0.190400970823541 0.587635409691279 GO:0051119 sugar transmembrane transporter activity 5/2058 28/18639 0.178571428571429 1.61729487713453 0.190546309787805 0.587635409691279 GO:0005245 voltage-gated calcium channel activity 7/2058 43/18639 0.162790697674419 1.47437114380636 0.191195268677016 0.588184459550722 GO:0031072 heat shock protein binding 18/2058 131/18639 0.137404580152672 1.24445285202412 0.194855199821555 0.590406659874432 GO:0004705 JUN kinase activity 3/2058 14/18639 0.214285714285714 1.94075385256143 0.19533563229172 0.590406659874432 GO:0019763 immunoglobulin receptor activity 3/2058 14/18639 0.214285714285714 1.94075385256143 0.19533563229172 0.590406659874432 GO:0034236 protein kinase A catalytic subunit binding 3/2058 14/18639 0.214285714285714 1.94075385256143 0.19533563229172 0.590406659874432 GO:0071933 Arp2/3 complex binding 3/2058 14/18639 0.214285714285714 1.94075385256143 0.19533563229172 0.590406659874432 GO:1901612 cardiolipin binding 3/2058 14/18639 0.214285714285714 1.94075385256143 0.19533563229172 0.590406659874432 GO:0015174 basic amino acid transmembrane transporter activity 4/2058 21/18639 0.19047619047619 1.72511453561016 0.195699245146529 0.590406659874432 GO:0072542 protein phosphatase activator activity 4/2058 21/18639 0.19047619047619 1.72511453561016 0.195699245146529 0.590406659874432 GO:0016500 protein-hormone receptor activity 10/2058 67/18639 0.149253731343284 1.35176885253035 0.200777228656594 0.603545409539532 GO:0004033 aldo-keto reductase (NADPH) activity 6/2058 36/18639 0.166666666666667 1.50947521865889 0.201020728877859 0.603545409539532 GO:0001046 core promoter sequence-specific DNA binding 7/2058 44/18639 0.159090909090909 1.44086270871985 0.207278113412959 0.619354936968386 GO:0043014 alpha-tubulin binding 7/2058 44/18639 0.159090909090909 1.44086270871985 0.207278113412959 0.619354936968386 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 5/2058 29/18639 0.172413793103448 1.56152608826782 0.210821868453039 0.624364755153942 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 5/2058 29/18639 0.172413793103448 1.56152608826782 0.210821868453039 0.624364755153942 GO:0097472 cyclin-dependent protein kinase activity 5/2058 29/18639 0.172413793103448 1.56152608826782 0.210821868453039 0.624364755153942 GO:0030159 signaling receptor complex adaptor activity 8/2058 52/18639 0.153846153846154 1.39336174030052 0.210954304783798 0.624364755153942 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 9/2058 60/18639 0.15 1.358527696793 0.212947364546442 0.628255901887605 GO:0004860 protein kinase inhibitor activity 12/2058 84/18639 0.142857142857143 1.29383590170762 0.213275021937826 0.628255901887605 GO:0019842 vitamin binding 20/2058 150/18639 0.133333333333333 1.20758017492711 0.216936746387386 0.637538814677283 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 4/2058 22/18639 0.181818181818182 1.64670023853697 0.219767101678961 0.638346767434936 GO:0016881 acid-amino acid ligase activity 4/2058 22/18639 0.181818181818182 1.64670023853697 0.219767101678961 0.638346767434936 GO:0030021 extracellular matrix structural constituent conferring compression resistance 4/2058 22/18639 0.181818181818182 1.64670023853697 0.219767101678961 0.638346767434936 GO:0031683 G-protein beta/gamma-subunit complex binding 4/2058 22/18639 0.181818181818182 1.64670023853697 0.219767101678961 0.638346767434936 GO:0061133 endopeptidase activator activity 4/2058 22/18639 0.181818181818182 1.64670023853697 0.219767101678961 0.638346767434936 GO:0051213 dioxygenase activity 13/2058 93/18639 0.139784946236559 1.26601147371391 0.223628479882159 0.648055618034378 GO:0000774 adenyl-nucleotide exchange factor activity 3/2058 15/18639 0.2 1.81137026239067 0.225427680383065 0.648753854374305 GO:0004953 icosanoid receptor activity 3/2058 15/18639 0.2 1.81137026239067 0.225427680383065 0.648753854374305 GO:0140776 protein-containing complex destabilizing activity 3/2058 15/18639 0.2 1.81137026239067 0.225427680383065 0.648753854374305 GO:0016860 intramolecular oxidoreductase activity 8/2058 53/18639 0.150943396226415 1.3670718961439 0.226241279195611 0.649598523483491 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 5/2058 30/18639 0.166666666666667 1.50947521865889 0.231746898694389 0.657845173793845 GO:0008106 alcohol dehydrogenase (NADP+) activity 5/2058 30/18639 0.166666666666667 1.50947521865889 0.231746898694389 0.657845173793845 GO:0022839 monoatomic ion-gated channel activity 5/2058 30/18639 0.166666666666667 1.50947521865889 0.231746898694389 0.657845173793845 GO:0031210 phosphatidylcholine binding 5/2058 30/18639 0.166666666666667 1.50947521865889 0.231746898694389 0.657845173793845 GO:0070566 adenylyltransferase activity 5/2058 30/18639 0.166666666666667 1.50947521865889 0.231746898694389 0.657845173793845 GO:0042826 histone deacetylase binding 17/2058 127/18639 0.133858267716535 1.21233442758431 0.235010910244392 0.665597793413254 GO:0042887 amide transmembrane transporter activity 6/2058 38/18639 0.157894736842105 1.43002915451895 0.237892303556574 0.672234133805794 GO:0016782 transferase activity, transferring sulphur-containing groups 10/2058 70/18639 0.142857142857143 1.29383590170762 0.240793117712471 0.678895268674666 GO:0140789 histone phosphatase activity 18/2058 136/18639 0.132352941176471 1.198700908935 0.241655457245696 0.679792040765482 GO:0004022 alcohol dehydrogenase (NAD+) activity 4/2058 23/18639 0.173913043478261 1.57510457599189 0.244560485118621 0.683346858866125 GO:0016849 phosphorus-oxygen lyase activity 4/2058 23/18639 0.173913043478261 1.57510457599189 0.244560485118621 0.683346858866125 GO:0017134 fibroblast growth factor binding 4/2058 23/18639 0.173913043478261 1.57510457599189 0.244560485118621 0.683346858866125 GO:0033293 monocarboxylic acid binding 11/2058 79/18639 0.139240506329114 1.26108056242388 0.252411691405168 0.697475455667716 GO:0005164 tumor necrosis factor receptor binding 5/2058 31/18639 0.161290322580645 1.4607824696699 0.253227497454033 0.697475455667716 GO:0072349 modified amino acid transmembrane transporter activity 5/2058 31/18639 0.161290322580645 1.4607824696699 0.253227497454033 0.697475455667716 GO:0005506 iron ion binding 20/2058 154/18639 0.12987012987013 1.17621445609784 0.2534059165193 0.697475455667716 GO:0046943 carboxylic acid transmembrane transporter activity 24/2058 188/18639 0.127659574468085 1.15619378450468 0.254979110179155 0.697475455667716 GO:0000062 fatty-acyl-CoA binding 3/2058 16/18639 0.1875 1.69815962099125 0.256318041754589 0.697475455667716 GO:0004707 MAP kinase activity 3/2058 16/18639 0.1875 1.69815962099125 0.256318041754589 0.697475455667716 GO:0005024 transforming growth factor beta receptor activity 3/2058 16/18639 0.1875 1.69815962099125 0.256318041754589 0.697475455667716 GO:0005159 insulin-like growth factor receptor binding 3/2058 16/18639 0.1875 1.69815962099125 0.256318041754589 0.697475455667716 GO:0005521 lamin binding 3/2058 16/18639 0.1875 1.69815962099125 0.256318041754589 0.697475455667716 GO:0015385 sodium:proton antiporter activity 3/2058 16/18639 0.1875 1.69815962099125 0.256318041754589 0.697475455667716 GO:0019841 retinol binding 3/2058 16/18639 0.1875 1.69815962099125 0.256318041754589 0.697475455667716 GO:0016776 phosphotransferase activity, phosphate group as acceptor 6/2058 39/18639 0.153846153846154 1.39336174030052 0.25704669631755 0.697937660218739 GO:0035173 histone kinase activity 44/2058 360/18639 0.122222222222222 1.10694849368319 0.25798724991014 0.698971963422482 GO:0005342 organic acid transmembrane transporter activity 24/2058 189/18639 0.126984126984127 1.15007635707344 0.2635649313099 0.712538093519622 GO:0019957 C-C chemokine binding 4/2058 24/18639 0.166666666666667 1.50947521865889 0.269926955843094 0.725565672719235 GO:0070300 phosphatidic acid binding 4/2058 24/18639 0.166666666666667 1.50947521865889 0.269926955843094 0.725565672719235 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 16/2058 122/18639 0.131147540983607 1.18778377861683 0.270126531476737 0.725565672719235 GO:0015106 bicarbonate transmembrane transporter activity 5/2058 32/18639 0.15625 1.41513301749271 0.275169375671373 0.732559448765666 GO:0022884 macromolecule transmembrane transporter activity 5/2058 32/18639 0.15625 1.41513301749271 0.275169375671373 0.732559448765666 GO:0016879 ligase activity, forming carbon-nitrogen bonds 7/2058 48/18639 0.145833333333333 1.32079081632653 0.276005042155683 0.732559448765666 GO:0061791 GTPase motor activity 6/2058 40/18639 0.15 1.358527696793 0.276593990379752 0.732559448765666 GO:0140662 ATP-dependent protein folding chaperone 6/2058 40/18639 0.15 1.358527696793 0.276593990379752 0.732559448765666 GO:1990606 membrane scission GTPase motor activity 6/2058 40/18639 0.15 1.358527696793 0.276593990379752 0.732559448765666 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 33/2058 268/18639 0.123134328358209 1.11520930333754 0.278358316238045 0.732559448765666 GO:0004725 protein tyrosine phosphatase activity 13/2058 98/18639 0.13265306122449 1.20141905158565 0.283700178990787 0.732559448765666 GO:0120013 lipid transfer activity 9/2058 65/18639 0.138461538461538 1.25402556627046 0.287244389025291 0.732559448765666 GO:0004550 nucleoside diphosphate kinase activity 3/2058 17/18639 0.176470588235294 1.59826787858 0.287725687121127 0.732559448765666 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 3/2058 17/18639 0.176470588235294 1.59826787858 0.287725687121127 0.732559448765666 GO:0005092 GDP-dissociation inhibitor activity 3/2058 17/18639 0.176470588235294 1.59826787858 0.287725687121127 0.732559448765666 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 3/2058 17/18639 0.176470588235294 1.59826787858 0.287725687121127 0.732559448765666 GO:0019198 transmembrane receptor protein phosphatase activity 3/2058 17/18639 0.176470588235294 1.59826787858 0.287725687121127 0.732559448765666 GO:0045125 bioactive lipid receptor activity 3/2058 17/18639 0.176470588235294 1.59826787858 0.287725687121127 0.732559448765666 GO:0045236 CXCR chemokine receptor binding 3/2058 17/18639 0.176470588235294 1.59826787858 0.287725687121127 0.732559448765666 GO:1901567 fatty acid derivative binding 3/2058 17/18639 0.176470588235294 1.59826787858 0.287725687121127 0.732559448765666 GO:0001217 DNA-binding transcription repressor activity 34/2058 278/18639 0.122302158273381 1.107672462613 0.288451080130396 0.732559448765666 GO:0019207 kinase regulator activity 35/2058 287/18639 0.121951219512195 1.10449406243334 0.290957777209848 0.732559448765666 GO:0140996 histone H3 kinase activity 43/2058 357/18639 0.120448179271709 1.09088125045937 0.294291630676351 0.732559448765666 GO:0001848 complement binding 4/2058 25/18639 0.16 1.44909620991254 0.295718391116829 0.732559448765666 GO:0140828 metal cation:monoatomic cation antiporter activity 6/2058 41/18639 0.146341463414634 1.32539287492 0.296469042024449 0.732559448765666 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 5/2058 33/18639 0.151515151515152 1.37225019878081 0.297479004275653 0.732559448765666 GO:0019239 deaminase activity 5/2058 33/18639 0.151515151515152 1.37225019878081 0.297479004275653 0.732559448765666 GO:0030296 protein tyrosine kinase activator activity 5/2058 33/18639 0.151515151515152 1.37225019878081 0.297479004275653 0.732559448765666 GO:0000182 rDNA binding 2/2058 10/18639 0.2 1.81137026239067 0.304402204891418 0.732559448765666 GO:0003680 minor groove of adenine-thymine-rich DNA binding 2/2058 10/18639 0.2 1.81137026239067 0.304402204891418 0.732559448765666 GO:0005381 iron ion transmembrane transporter activity 2/2058 10/18639 0.2 1.81137026239067 0.304402204891418 0.732559448765666 GO:0005528 FK506 binding 2/2058 10/18639 0.2 1.81137026239067 0.304402204891418 0.732559448765666 GO:0008401 retinoic acid 4-hydroxylase activity 2/2058 10/18639 0.2 1.81137026239067 0.304402204891418 0.732559448765666 GO:0008641 ubiquitin-like modifier activating enzyme activity 2/2058 10/18639 0.2 1.81137026239067 0.304402204891418 0.732559448765666 GO:0015924 mannosyl-oligosaccharide mannosidase activity 2/2058 10/18639 0.2 1.81137026239067 0.304402204891418 0.732559448765666 GO:0016427 tRNA (cytidine) methyltransferase activity 2/2058 10/18639 0.2 1.81137026239067 0.304402204891418 0.732559448765666 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 2/2058 10/18639 0.2 1.81137026239067 0.304402204891418 0.732559448765666 GO:0019911 structural constituent of myelin sheath 2/2058 10/18639 0.2 1.81137026239067 0.304402204891418 0.732559448765666 GO:0030957 Tat protein binding 2/2058 10/18639 0.2 1.81137026239067 0.304402204891418 0.732559448765666 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 2/2058 10/18639 0.2 1.81137026239067 0.304402204891418 0.732559448765666 GO:0032052 bile acid binding 2/2058 10/18639 0.2 1.81137026239067 0.304402204891418 0.732559448765666 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 2/2058 10/18639 0.2 1.81137026239067 0.304402204891418 0.732559448765666 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 2/2058 10/18639 0.2 1.81137026239067 0.304402204891418 0.732559448765666 GO:0035256 G protein-coupled glutamate receptor binding 2/2058 10/18639 0.2 1.81137026239067 0.304402204891418 0.732559448765666 GO:0035374 chondroitin sulfate binding 2/2058 10/18639 0.2 1.81137026239067 0.304402204891418 0.732559448765666 GO:0042975 peroxisome proliferator activated receptor binding 2/2058 10/18639 0.2 1.81137026239067 0.304402204891418 0.732559448765666 GO:0043121 neurotrophin binding 2/2058 10/18639 0.2 1.81137026239067 0.304402204891418 0.732559448765666 GO:0043208 glycosphingolipid binding 2/2058 10/18639 0.2 1.81137026239067 0.304402204891418 0.732559448765666 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 2/2058 10/18639 0.2 1.81137026239067 0.304402204891418 0.732559448765666 GO:0043422 protein kinase B binding 2/2058 10/18639 0.2 1.81137026239067 0.304402204891418 0.732559448765666 GO:0047429 nucleoside triphosphate diphosphatase activity 2/2058 10/18639 0.2 1.81137026239067 0.304402204891418 0.732559448765666 GO:0051880 G-quadruplex DNA binding 2/2058 10/18639 0.2 1.81137026239067 0.304402204891418 0.732559448765666 GO:0070097 delta-catenin binding 2/2058 10/18639 0.2 1.81137026239067 0.304402204891418 0.732559448765666 GO:0070513 death domain binding 2/2058 10/18639 0.2 1.81137026239067 0.304402204891418 0.732559448765666 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 2/2058 10/18639 0.2 1.81137026239067 0.304402204891418 0.732559448765666 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 2/2058 10/18639 0.2 1.81137026239067 0.304402204891418 0.732559448765666 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 2/2058 10/18639 0.2 1.81137026239067 0.304402204891418 0.732559448765666 GO:0051087 protein-folding chaperone binding 17/2058 134/18639 0.126865671641791 1.1490035246508 0.308936455120694 0.741832313287464 GO:0019208 phosphatase regulator activity 15/2058 117/18639 0.128205128205128 1.16113478358376 0.309443262788446 0.741832313287464 GO:0019887 protein kinase regulator activity 31/2058 255/18639 0.12156862745098 1.10102898302178 0.311602612649207 0.74557789884839 GO:0032813 tumor necrosis factor receptor superfamily binding 7/2058 50/18639 0.14 1.26795918367347 0.312345913033057 0.745927429021583 GO:0019894 kinesin binding 6/2058 42/18639 0.142857142857143 1.29383590170762 0.316607044893694 0.754660685252334 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 3/2058 18/18639 0.166666666666667 1.50947521865889 0.319392954630475 0.758337983905044 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 3/2058 18/18639 0.166666666666667 1.50947521865889 0.319392954630475 0.758337983905044 GO:0019825 oxygen binding 5/2058 34/18639 0.147058823529412 1.33188989881667 0.320064622403026 0.758337983905044 GO:0005112 Notch binding 4/2058 26/18639 0.153846153846154 1.39336174030052 0.321792739367232 0.758337983905044 GO:0030247 polysaccharide binding 4/2058 26/18639 0.153846153846154 1.39336174030052 0.321792739367232 0.758337983905044 GO:0050681 nuclear androgen receptor binding 4/2058 26/18639 0.153846153846154 1.39336174030052 0.321792739367232 0.758337983905044 GO:0070063 RNA polymerase binding 8/2058 59/18639 0.135593220338983 1.2280476355191 0.324742894316311 0.763849105463412 GO:0030145 manganese ion binding 9/2058 68/18639 0.132352941176471 1.198700908935 0.33475201383317 0.777495871716105 GO:0016853 isomerase activity 22/2058 180/18639 0.122222222222222 1.10694849368319 0.339391254586409 0.777495871716105 GO:0015293 symporter activity 18/2058 146/18639 0.123287671232877 1.11659810695315 0.346460493103436 0.777495871716105 GO:0001851 complement component C3b binding 2/2058 11/18639 0.181818181818182 1.64670023853697 0.346948928111904 0.777495871716105 GO:0003953 NAD+ nucleosidase activity 2/2058 11/18639 0.181818181818182 1.64670023853697 0.346948928111904 0.777495871716105 GO:0004143 ATP-dependent diacylglycerol kinase activity 2/2058 11/18639 0.181818181818182 1.64670023853697 0.346948928111904 0.777495871716105 GO:0005225 volume-sensitive anion channel activity 2/2058 11/18639 0.181818181818182 1.64670023853697 0.346948928111904 0.777495871716105 GO:0005536 D-glucose binding 2/2058 11/18639 0.181818181818182 1.64670023853697 0.346948928111904 0.777495871716105 GO:0008199 ferric iron binding 2/2058 11/18639 0.181818181818182 1.64670023853697 0.346948928111904 0.777495871716105 GO:0015173 aromatic amino acid transmembrane transporter activity 2/2058 11/18639 0.181818181818182 1.64670023853697 0.346948928111904 0.777495871716105 GO:0015205 nucleobase transmembrane transporter activity 2/2058 11/18639 0.181818181818182 1.64670023853697 0.346948928111904 0.777495871716105 GO:0016176 superoxide-generating NADPH oxidase activator activity 2/2058 11/18639 0.181818181818182 1.64670023853697 0.346948928111904 0.777495871716105 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 2/2058 11/18639 0.181818181818182 1.64670023853697 0.346948928111904 0.777495871716105 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 2/2058 11/18639 0.181818181818182 1.64670023853697 0.346948928111904 0.777495871716105 GO:0019215 intermediate filament binding 2/2058 11/18639 0.181818181818182 1.64670023853697 0.346948928111904 0.777495871716105 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 2/2058 11/18639 0.181818181818182 1.64670023853697 0.346948928111904 0.777495871716105 GO:0032794 GTPase activating protein binding 2/2058 11/18639 0.181818181818182 1.64670023853697 0.346948928111904 0.777495871716105 GO:0034713 type I transforming growth factor beta receptor binding 2/2058 11/18639 0.181818181818182 1.64670023853697 0.346948928111904 0.777495871716105 GO:0045294 alpha-catenin binding 2/2058 11/18639 0.181818181818182 1.64670023853697 0.346948928111904 0.777495871716105 GO:0050786 RAGE receptor binding 2/2058 11/18639 0.181818181818182 1.64670023853697 0.346948928111904 0.777495871716105 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 2/2058 11/18639 0.181818181818182 1.64670023853697 0.346948928111904 0.777495871716105 GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 2/2058 11/18639 0.181818181818182 1.64670023853697 0.346948928111904 0.777495871716105 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 2/2058 11/18639 0.181818181818182 1.64670023853697 0.346948928111904 0.777495871716105 GO:0004683 calcium/calmodulin-dependent protein kinase activity 4/2058 27/18639 0.148148148148148 1.34175574991902 0.348015396859166 0.777495871716105 GO:0005104 fibroblast growth factor receptor binding 4/2058 27/18639 0.148148148148148 1.34175574991902 0.348015396859166 0.777495871716105 GO:0008266 poly(U) RNA binding 4/2058 27/18639 0.148148148148148 1.34175574991902 0.348015396859166 0.777495871716105 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 7/2058 52/18639 0.134615384615385 1.21919152276295 0.349491112873692 0.777495871716105 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 11/2058 86/18639 0.127906976744186 1.15843447013357 0.350039558263724 0.777495871716105 GO:0002039 p53 binding 9/2058 69/18639 0.130434782608696 1.18132843199392 0.350894122805808 0.777495871716105 GO:0015245 fatty acid transmembrane transporter activity 3/2058 19/18639 0.157894736842105 1.43002915451895 0.351087006923846 0.777495871716105 GO:0034987 immunoglobulin receptor binding 3/2058 19/18639 0.157894736842105 1.43002915451895 0.351087006923846 0.777495871716105 GO:0097001 ceramide binding 3/2058 19/18639 0.157894736842105 1.43002915451895 0.351087006923846 0.777495871716105 GO:0120227 acyl-CoA binding 3/2058 19/18639 0.157894736842105 1.43002915451895 0.351087006923846 0.777495871716105 GO:0003697 single-stranded DNA binding 15/2058 121/18639 0.12396694214876 1.12275016263885 0.357654493764941 0.790637987101613 GO:0044390 ubiquitin-like protein conjugating enzyme binding 5/2058 36/18639 0.138888888888889 1.25789601554908 0.365710718173232 0.802763949030523 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 5/2058 36/18639 0.138888888888889 1.25789601554908 0.365710718173232 0.802763949030523 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 5/2058 36/18639 0.138888888888889 1.25789601554908 0.365710718173232 0.802763949030523 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 5/2058 36/18639 0.138888888888889 1.25789601554908 0.365710718173232 0.802763949030523 GO:0008028 monocarboxylic acid transmembrane transporter activity 9/2058 70/18639 0.128571428571429 1.16445231153686 0.367138533393349 0.804484260014549 GO:0019789 SUMO transferase activity 4/2058 28/18639 0.142857142857143 1.29383590170762 0.374260244704392 0.81579589116193 GO:0045499 chemorepellent activity 4/2058 28/18639 0.142857142857143 1.29383590170762 0.374260244704392 0.81579589116193 GO:0051019 mitogen-activated protein kinase binding 4/2058 28/18639 0.142857142857143 1.29383590170762 0.374260244704392 0.81579589116193 GO:0001972 retinoic acid binding 3/2058 20/18639 0.15 1.358527696793 0.382600330827788 0.821222327321743 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 16/2058 132/18639 0.121212121212121 1.09780015902465 0.385488784763249 0.821222327321743 GO:0003925 G protein activity 7/2058 54/18639 0.12962962962963 1.17403628117914 0.387062328419298 0.821222327321743 GO:0004126 cytidine deaminase activity 2/2058 12/18639 0.166666666666667 1.50947521865889 0.388584784185068 0.821222327321743 GO:0004300 enoyl-CoA hydratase activity 2/2058 12/18639 0.166666666666667 1.50947521865889 0.388584784185068 0.821222327321743 GO:0004859 phospholipase inhibitor activity 2/2058 12/18639 0.166666666666667 1.50947521865889 0.388584784185068 0.821222327321743 GO:0005049 nuclear export signal receptor activity 2/2058 12/18639 0.166666666666667 1.50947521865889 0.388584784185068 0.821222327321743 GO:0005247 voltage-gated chloride channel activity 2/2058 12/18639 0.166666666666667 1.50947521865889 0.388584784185068 0.821222327321743 GO:0005527 macrolide binding 2/2058 12/18639 0.166666666666667 1.50947521865889 0.388584784185068 0.821222327321743 GO:0010853 cyclase activator activity 2/2058 12/18639 0.166666666666667 1.50947521865889 0.388584784185068 0.821222327321743 GO:0015132 prostaglandin transmembrane transporter activity 2/2058 12/18639 0.166666666666667 1.50947521865889 0.388584784185068 0.821222327321743 GO:0015166 polyol transmembrane transporter activity 2/2058 12/18639 0.166666666666667 1.50947521865889 0.388584784185068 0.821222327321743 GO:0035259 nuclear glucocorticoid receptor binding 2/2058 12/18639 0.166666666666667 1.50947521865889 0.388584784185068 0.821222327321743 GO:0035497 cAMP response element binding 2/2058 12/18639 0.166666666666667 1.50947521865889 0.388584784185068 0.821222327321743 GO:0097371 MDM2/MDM4 family protein binding 2/2058 12/18639 0.166666666666667 1.50947521865889 0.388584784185068 0.821222327321743 GO:0097677 STAT family protein binding 2/2058 12/18639 0.166666666666667 1.50947521865889 0.388584784185068 0.821222327321743 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 2/2058 12/18639 0.166666666666667 1.50947521865889 0.388584784185068 0.821222327321743 GO:0141221 histone deacetylase activity, hydrolytic mechanism 2/2058 12/18639 0.166666666666667 1.50947521865889 0.388584784185068 0.821222327321743 GO:1901981 phosphatidylinositol phosphate binding 22/2058 185/18639 0.118918918918919 1.07703096682689 0.389334449037452 0.821416768323948 GO:0003727 single-stranded RNA binding 11/2058 89/18639 0.123595505617978 1.11938611720772 0.393765234716347 0.829363875481818 GO:0141003 histone H2AX kinase activity 41/2058 354/18639 0.115819209039548 1.04895735533923 0.396626668079684 0.83398435762883 GO:0004180 carboxypeptidase activity 6/2058 46/18639 0.130434782608696 1.18132843199392 0.398533937345254 0.83491247202981 GO:0004181 metallocarboxypeptidase activity 4/2058 29/18639 0.137931034482759 1.24922087061426 0.400410384904608 0.83491247202981 GO:0035250 UDP-galactosyltransferase activity 4/2058 29/18639 0.137931034482759 1.24922087061426 0.400410384904608 0.83491247202981 GO:0043236 laminin binding 4/2058 29/18639 0.137931034482759 1.24922087061426 0.400410384904608 0.83491247202981 GO:0051861 glycolipid binding 4/2058 29/18639 0.137931034482759 1.24922087061426 0.400410384904608 0.83491247202981 GO:0019888 protein phosphatase regulator activity 13/2058 107/18639 0.121495327102804 1.10036511266723 0.401288400082316 0.835348686171354 GO:0008374 O-acyltransferase activity 7/2058 55/18639 0.127272727272727 1.15269016697588 0.405894080090518 0.842129079789132 GO:0098632 cell-cell adhesion mediator activity 7/2058 55/18639 0.127272727272727 1.15269016697588 0.405894080090518 0.842129079789132 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 3/2058 21/18639 0.142857142857143 1.29383590170762 0.413750511774666 0.85417254414307 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 3/2058 21/18639 0.142857142857143 1.29383590170762 0.413750511774666 0.85417254414307 GO:0009975 cyclase activity 3/2058 21/18639 0.142857142857143 1.29383590170762 0.413750511774666 0.85417254414307 GO:0005504 fatty acid binding 6/2058 47/18639 0.127659574468085 1.15619378450468 0.419062276970783 0.859456131258634 GO:0061749 forked DNA-dependent helicase activity 6/2058 47/18639 0.127659574468085 1.15619378450468 0.419062276970783 0.859456131258634 GO:0099095 ligand-gated monoatomic anion channel activity 6/2058 47/18639 0.127659574468085 1.15619378450468 0.419062276970783 0.859456131258634 GO:1990518 single-stranded 3'-5' DNA helicase activity 6/2058 47/18639 0.127659574468085 1.15619378450468 0.419062276970783 0.859456131258634 GO:0019903 protein phosphatase binding 17/2058 144/18639 0.118055555555556 1.06921161321672 0.423273141223176 0.862820207850937 GO:0008187 poly-pyrimidine tract binding 4/2058 30/18639 0.133333333333333 1.20758017492711 0.426358613552335 0.862820207850937 GO:0031624 ubiquitin conjugating enzyme binding 4/2058 30/18639 0.133333333333333 1.20758017492711 0.426358613552335 0.862820207850937 GO:0033612 receptor serine/threonine kinase binding 4/2058 30/18639 0.133333333333333 1.20758017492711 0.426358613552335 0.862820207850937 GO:0098918 structural constituent of synapse 4/2058 30/18639 0.133333333333333 1.20758017492711 0.426358613552335 0.862820207850937 GO:0008035 high-density lipoprotein particle binding 2/2058 13/18639 0.153846153846154 1.39336174030052 0.428992273078808 0.862820207850937 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 2/2058 13/18639 0.153846153846154 1.39336174030052 0.428992273078808 0.862820207850937 GO:0031432 titin binding 2/2058 13/18639 0.153846153846154 1.39336174030052 0.428992273078808 0.862820207850937 GO:0035673 oligopeptide transmembrane transporter activity 2/2058 13/18639 0.153846153846154 1.39336174030052 0.428992273078808 0.862820207850937 GO:0039706 co-receptor binding 2/2058 13/18639 0.153846153846154 1.39336174030052 0.428992273078808 0.862820207850937 GO:0070123 transforming growth factor beta receptor activity, type III 2/2058 13/18639 0.153846153846154 1.39336174030052 0.428992273078808 0.862820207850937 GO:0071714 icosanoid transmembrane transporter activity 2/2058 13/18639 0.153846153846154 1.39336174030052 0.428992273078808 0.862820207850937 GO:0000217 DNA secondary structure binding 5/2058 39/18639 0.128205128205128 1.16113478358376 0.434143466681386 0.870377511854015 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 5/2058 39/18639 0.128205128205128 1.16113478358376 0.434143466681386 0.870377511854015 GO:0051020 GTPase binding 36/2058 315/18639 0.114285714285714 1.0350687213661 0.439261786880397 0.875493272690732 GO:0009378 four-way junction helicase activity 6/2058 48/18639 0.125 1.13210641399417 0.439499024801512 0.875493272690732 GO:0036121 double-stranded DNA helicase activity 6/2058 48/18639 0.125 1.13210641399417 0.439499024801512 0.875493272690732 GO:0043138 3'-5' DNA helicase activity 6/2058 48/18639 0.125 1.13210641399417 0.439499024801512 0.875493272690732 GO:0008093 cytoskeletal anchor activity 3/2058 22/18639 0.136363636363636 1.23502517890273 0.444379471263461 0.880999935885813 GO:0008970 phospholipase A1 activity 3/2058 22/18639 0.136363636363636 1.23502517890273 0.444379471263461 0.880999935885813 GO:0050321 tau-protein kinase activity 3/2058 22/18639 0.136363636363636 1.23502517890273 0.444379471263461 0.880999935885813 GO:0004674 protein serine/threonine kinase activity 49/2058 433/18639 0.113163972286374 1.0249092708677 0.449796543558133 0.890326280355164 GO:0047499 calcium-independent phospholipase A2 activity 4/2058 31/18639 0.129032258064516 1.16862597573592 0.45200766778912 0.89187610911313 GO:0070273 phosphatidylinositol-4-phosphate binding 4/2058 31/18639 0.129032258064516 1.16862597573592 0.45200766778912 0.89187610911313 GO:0015171 amino acid transmembrane transporter activity 12/2058 102/18639 0.117647058823529 1.06551191905334 0.453800108278027 0.894000528768542 GO:1902936 phosphatidylinositol bisphosphate binding 13/2058 111/18639 0.117117117117117 1.06071231581436 0.454959910548547 0.894873902795488 GO:0050997 quaternary ammonium group binding 5/2058 40/18639 0.125 1.13210641399417 0.456650534724477 0.896786977784389 GO:0060590 ATPase regulator activity 6/2058 49/18639 0.122448979591837 1.10900220146368 0.459794118668982 0.899463996042735 GO:0061980 regulatory RNA binding 7/2058 58/18639 0.120689655172414 1.09306826178747 0.46206563514545 0.899463996042735 GO:0016791 phosphatase activity 31/2058 273/18639 0.113553113553114 1.0284336654599 0.462588867656882 0.899463996042735 GO:0004065 arylsulfatase activity 2/2058 14/18639 0.142857142857143 1.29383590170762 0.467935046543323 0.899463996042735 GO:0005344 oxygen carrier activity 2/2058 14/18639 0.142857142857143 1.29383590170762 0.467935046543323 0.899463996042735 GO:0005545 1-phosphatidylinositol binding 2/2058 14/18639 0.142857142857143 1.29383590170762 0.467935046543323 0.899463996042735 GO:0008174 mRNA methyltransferase activity 2/2058 14/18639 0.142857142857143 1.29383590170762 0.467935046543323 0.899463996042735 GO:0015386 potassium:proton antiporter activity 2/2058 14/18639 0.142857142857143 1.29383590170762 0.467935046543323 0.899463996042735 GO:0042813 Wnt receptor activity 2/2058 14/18639 0.142857142857143 1.29383590170762 0.467935046543323 0.899463996042735 GO:0044548 S100 protein binding 2/2058 14/18639 0.142857142857143 1.29383590170762 0.467935046543323 0.899463996042735 GO:0046030 inositol trisphosphate phosphatase activity 2/2058 14/18639 0.142857142857143 1.29383590170762 0.467935046543323 0.899463996042735 GO:0070742 C2H2 zinc finger domain binding 2/2058 14/18639 0.142857142857143 1.29383590170762 0.467935046543323 0.899463996042735 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 2/2058 14/18639 0.142857142857143 1.29383590170762 0.467935046543323 0.899463996042735 GO:0005200 structural constituent of cytoskeleton 13/2058 112/18639 0.116071428571429 1.05124167013744 0.468330130333063 0.899463996042735 GO:0030295 protein kinase activator activity 16/2058 139/18639 0.115107913669065 1.04251525892988 0.469576682748493 0.899463996042735 GO:0019209 kinase activator activity 17/2058 148/18639 0.114864864864865 1.0403140020487 0.469869384315606 0.899463996042735 GO:0004721 phosphoprotein phosphatase activity 20/2058 175/18639 0.114285714285714 1.0350687213661 0.470501787207473 0.899463996042735 GO:0016493 C-C chemokine receptor activity 3/2058 23/18639 0.130434782608696 1.18132843199392 0.474352319185187 0.899463996042735 GO:0042171 lysophosphatidic acid acyltransferase activity 3/2058 23/18639 0.130434782608696 1.18132843199392 0.474352319185187 0.899463996042735 GO:0071617 lysophospholipid acyltransferase activity 3/2058 23/18639 0.130434782608696 1.18132843199392 0.474352319185187 0.899463996042735 GO:0099186 structural constituent of postsynapse 3/2058 23/18639 0.130434782608696 1.18132843199392 0.474352319185187 0.899463996042735 GO:0140103 catalytic activity, acting on a glycoprotein 3/2058 23/18639 0.130434782608696 1.18132843199392 0.474352319185187 0.899463996042735 GO:0008378 galactosyltransferase activity 4/2058 32/18639 0.125 1.13210641399417 0.477270280948799 0.899463996042735 GO:0070717 poly-purine tract binding 4/2058 32/18639 0.125 1.13210641399417 0.477270280948799 0.899463996042735 GO:0071813 lipoprotein particle binding 4/2058 32/18639 0.125 1.13210641399417 0.477270280948799 0.899463996042735 GO:0071814 protein-lipid complex binding 4/2058 32/18639 0.125 1.13210641399417 0.477270280948799 0.899463996042735 GO:0001530 lipopolysaccharide binding 5/2058 41/18639 0.121951219512195 1.10449406243334 0.478897964266148 0.899463996042735 GO:0061650 ubiquitin-like protein conjugating enzyme activity 5/2058 41/18639 0.121951219512195 1.10449406243334 0.478897964266148 0.899463996042735 GO:0140318 protein transporter activity 5/2058 41/18639 0.121951219512195 1.10449406243334 0.478897964266148 0.899463996042735 GO:0000287 magnesium ion binding 26/2058 230/18639 0.11304347826087 1.02381797439473 0.480414671655196 0.900211935585323 GO:0016209 antioxidant activity 10/2058 86/18639 0.116279069767442 1.05312224557597 0.48145842511689 0.900211935585323 GO:0050660 flavin adenine dinucleotide binding 10/2058 86/18639 0.116279069767442 1.05312224557597 0.48145842511689 0.900211935585323 GO:0016407 acetyltransferase activity 11/2058 96/18639 0.114583333333333 1.03776421282799 0.496024161288749 0.907985030591285 GO:0030544 Hsp70 protein binding 6/2058 51/18639 0.117647058823529 1.06551191905334 0.499775194164191 0.907985030591285 GO:0008307 structural constituent of muscle 5/2058 42/18639 0.119047619047619 1.07819658475635 0.50082916958675 0.907985030591285 GO:0016859 cis-trans isomerase activity 5/2058 42/18639 0.119047619047619 1.07819658475635 0.50082916958675 0.907985030591285 GO:0051879 Hsp90 protein binding 5/2058 42/18639 0.119047619047619 1.07819658475635 0.50082916958675 0.907985030591285 GO:0140311 protein sequestering activity 4/2058 33/18639 0.121212121212121 1.09780015902465 0.502069077731301 0.907985030591285 GO:0001091 RNA polymerase II general transcription initiation factor binding 3/2058 24/18639 0.125 1.13210641399417 0.503555942519772 0.907985030591285 GO:0004806 triacylglycerol lipase activity 3/2058 24/18639 0.125 1.13210641399417 0.503555942519772 0.907985030591285 GO:0015149 hexose transmembrane transporter activity 3/2058 24/18639 0.125 1.13210641399417 0.503555942519772 0.907985030591285 GO:0015295 solute:proton symporter activity 3/2058 24/18639 0.125 1.13210641399417 0.503555942519772 0.907985030591285 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 3/2058 24/18639 0.125 1.13210641399417 0.503555942519772 0.907985030591285 GO:0030215 semaphorin receptor binding 3/2058 24/18639 0.125 1.13210641399417 0.503555942519772 0.907985030591285 GO:0055056 D-glucose transmembrane transporter activity 3/2058 24/18639 0.125 1.13210641399417 0.503555942519772 0.907985030591285 GO:0015291 secondary active transmembrane transporter activity 32/2058 287/18639 0.111498257839721 1.00982314279619 0.504719291717099 0.907985030591285 GO:0004559 alpha-mannosidase activity 2/2058 15/18639 0.133333333333333 1.20758017492711 0.50524387210644 0.907985030591285 GO:0005041 low-density lipoprotein particle receptor activity 2/2058 15/18639 0.133333333333333 1.20758017492711 0.50524387210644 0.907985030591285 GO:0005402 carbohydrate:monoatomic cation symporter activity 2/2058 15/18639 0.133333333333333 1.20758017492711 0.50524387210644 0.907985030591285 GO:0015556 C4-dicarboxylate transmembrane transporter activity 2/2058 15/18639 0.133333333333333 1.20758017492711 0.50524387210644 0.907985030591285 GO:0016846 carbon-sulfur lyase activity 2/2058 15/18639 0.133333333333333 1.20758017492711 0.50524387210644 0.907985030591285 GO:0031386 protein tag activity 2/2058 15/18639 0.133333333333333 1.20758017492711 0.50524387210644 0.907985030591285 GO:0033130 acetylcholine receptor binding 2/2058 15/18639 0.133333333333333 1.20758017492711 0.50524387210644 0.907985030591285 GO:0034483 heparan sulfate sulfotransferase activity 2/2058 15/18639 0.133333333333333 1.20758017492711 0.50524387210644 0.907985030591285 GO:0045504 dynein heavy chain binding 2/2058 15/18639 0.133333333333333 1.20758017492711 0.50524387210644 0.907985030591285 GO:0047372 monoacylglycerol lipase activity 2/2058 15/18639 0.133333333333333 1.20758017492711 0.50524387210644 0.907985030591285 GO:0141047 molecular tag activity 2/2058 15/18639 0.133333333333333 1.20758017492711 0.50524387210644 0.907985030591285 GO:0141050 histone H3K deacetylase activity 2/2058 15/18639 0.133333333333333 1.20758017492711 0.50524387210644 0.907985030591285 GO:0141051 histone H4K deacetylase activity 2/2058 15/18639 0.133333333333333 1.20758017492711 0.50524387210644 0.907985030591285 GO:0005525 GTP binding 42/2058 378/18639 0.111111111111111 1.00631681243926 0.507368394193031 0.910492994751574 GO:0004497 monooxygenase activity 12/2058 106/18639 0.113207547169811 1.02530392210793 0.509179356667277 0.912431874429597 GO:0106310 protein serine kinase activity 40/2058 361/18639 0.110803324099723 1.00352923124137 0.515846712103183 0.92305521979495 GO:0016836 hydro-lyase activity 7/2058 61/18639 0.114754098360656 1.03931080628973 0.516953721984472 0.923712730699007 GO:0008200 ion channel inhibitor activity 5/2058 43/18639 0.116279069767442 1.05312224557597 0.522392995889534 0.932098359808612 GO:0015020 glucuronosyltransferase activity 4/2058 34/18639 0.117647058823529 1.06551191905334 0.526336338441738 0.936458812982523 GO:0016831 carboxy-lyase activity 4/2058 34/18639 0.117647058823529 1.06551191905334 0.526336338441738 0.936458812982523 GO:0140299 molecular sensor activity 8/2058 71/18639 0.112676056338028 1.0204902886708 0.531631781171043 0.937009712377555 GO:0005251 delayed rectifier potassium channel activity 3/2058 25/18639 0.12 1.0868221574344 0.531897426801991 0.937009712377555 GO:0015271 outward rectifier potassium channel activity 3/2058 25/18639 0.12 1.0868221574344 0.531897426801991 0.937009712377555 GO:0015662 P-type ion transporter activity 3/2058 25/18639 0.12 1.0868221574344 0.531897426801991 0.937009712377555 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 3/2058 25/18639 0.12 1.0868221574344 0.531897426801991 0.937009712377555 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 3/2058 25/18639 0.12 1.0868221574344 0.531897426801991 0.937009712377555 GO:0140358 P-type transmembrane transporter activity 3/2058 25/18639 0.12 1.0868221574344 0.531897426801991 0.937009712377555 GO:0004864 protein phosphatase inhibitor activity 6/2058 53/18639 0.113207547169811 1.02530392210793 0.53867077754628 0.942071236488557 GO:0005324 long-chain fatty acid transmembrane transporter activity 2/2058 16/18639 0.125 1.13210641399417 0.540804705013847 0.942071236488557 GO:0015378 sodium:chloride symporter activity 2/2058 16/18639 0.125 1.13210641399417 0.540804705013847 0.942071236488557 GO:0015923 mannosidase activity 2/2058 16/18639 0.125 1.13210641399417 0.540804705013847 0.942071236488557 GO:0016722 oxidoreductase activity, acting on metal ions 2/2058 16/18639 0.125 1.13210641399417 0.540804705013847 0.942071236488557 GO:0055102 lipase inhibitor activity 2/2058 16/18639 0.125 1.13210641399417 0.540804705013847 0.942071236488557 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 2/2058 16/18639 0.125 1.13210641399417 0.540804705013847 0.942071236488557 GO:0070411 I-SMAD binding 2/2058 16/18639 0.125 1.13210641399417 0.540804705013847 0.942071236488557 GO:0016248 channel inhibitor activity 5/2058 44/18639 0.113636363636364 1.02918764908561 0.543543679351459 0.945523754192161 GO:0031267 small GTPase binding 31/2058 283/18639 0.109540636042403 0.992093253252841 0.547354580575698 0.950828749845684 GO:0004623 phospholipase A2 activity 4/2058 35/18639 0.114285714285714 1.0350687213661 0.550013658427914 0.951477921574051 GO:0061631 ubiquitin conjugating enzyme activity 4/2058 35/18639 0.114285714285714 1.0350687213661 0.550013658427914 0.951477921574051 GO:0140566 histone reader activity 4/2058 35/18639 0.114285714285714 1.0350687213661 0.550013658427914 0.951477921574051 GO:0035091 phosphatidylinositol binding 31/2058 284/18639 0.109154929577465 0.988599967149838 0.555662174466878 0.951728447077291 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 14/2058 128/18639 0.109375 0.990593112244898 0.556992551859497 0.951728447077291 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 6/2058 54/18639 0.111111111111111 1.00631681243926 0.557621833687154 0.951728447077291 GO:0050661 NADP binding 6/2058 54/18639 0.111111111111111 1.00631681243926 0.557621833687154 0.951728447077291 GO:0140463 chromatin-protein adaptor activity 6/2058 54/18639 0.111111111111111 1.00631681243926 0.557621833687154 0.951728447077291 GO:0001637 G protein-coupled chemoattractant receptor activity 3/2058 26/18639 0.115384615384615 1.04502130522539 0.559302386032611 0.951728447077291 GO:0004950 chemokine receptor activity 3/2058 26/18639 0.115384615384615 1.04502130522539 0.559302386032611 0.951728447077291 GO:0005160 transforming growth factor beta receptor binding 3/2058 26/18639 0.115384615384615 1.04502130522539 0.559302386032611 0.951728447077291 GO:0008143 poly(A) binding 3/2058 26/18639 0.115384615384615 1.04502130522539 0.559302386032611 0.951728447077291 GO:0030507 spectrin binding 3/2058 26/18639 0.115384615384615 1.04502130522539 0.559302386032611 0.951728447077291 GO:0051139 metal cation:proton antiporter activity 3/2058 26/18639 0.115384615384615 1.04502130522539 0.559302386032611 0.951728447077291 GO:0120014 phospholipid transfer activity 3/2058 26/18639 0.115384615384615 1.04502130522539 0.559302386032611 0.951728447077291 GO:0046915 transition metal ion transmembrane transporter activity 5/2058 45/18639 0.111111111111111 1.00631681243926 0.564240752027439 0.956223472567533 GO:0051539 4 iron, 4 sulfur cluster binding 5/2058 45/18639 0.111111111111111 1.00631681243926 0.564240752027439 0.956223472567533 GO:0141110 transporter inhibitor activity 5/2058 45/18639 0.111111111111111 1.00631681243926 0.564240752027439 0.956223472567533 GO:0004659 prenyltransferase activity 2/2058 17/18639 0.117647058823529 1.06551191905334 0.57454857406621 0.963236468468049 GO:0008429 phosphatidylethanolamine binding 2/2058 17/18639 0.117647058823529 1.06551191905334 0.57454857406621 0.963236468468049 GO:0008484 sulfuric ester hydrolase activity 2/2058 17/18639 0.117647058823529 1.06551191905334 0.57454857406621 0.963236468468049 GO:0016018 cyclosporin A binding 2/2058 17/18639 0.117647058823529 1.06551191905334 0.57454857406621 0.963236468468049 GO:0030169 low-density lipoprotein particle binding 2/2058 17/18639 0.117647058823529 1.06551191905334 0.57454857406621 0.963236468468049 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 2/2058 17/18639 0.117647058823529 1.06551191905334 0.57454857406621 0.963236468468049 GO:0030548 acetylcholine receptor regulator activity 2/2058 17/18639 0.117647058823529 1.06551191905334 0.57454857406621 0.963236468468049 GO:0032183 SUMO binding 2/2058 17/18639 0.117647058823529 1.06551191905334 0.57454857406621 0.963236468468049 GO:0016874 ligase activity 18/2058 167/18639 0.107784431137725 0.976187566557846 0.58021185522435 0.970266874935212 GO:0003714 transcription corepressor activity 22/2058 204/18639 0.107843137254902 0.976719259132224 0.580295721038113 0.970266874935212 GO:0030276 clathrin binding 5/2058 46/18639 0.108695652173913 0.98444035999493 0.584448900159413 0.972813645398187 GO:0001671 ATPase activator activity 3/2058 27/18639 0.111111111111111 1.00631681243926 0.585713259679293 0.972813645398187 GO:0008395 steroid hydroxylase activity 3/2058 27/18639 0.111111111111111 1.00631681243926 0.585713259679293 0.972813645398187 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 3/2058 27/18639 0.111111111111111 1.00631681243926 0.585713259679293 0.972813645398187 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 3/2058 27/18639 0.111111111111111 1.00631681243926 0.585713259679293 0.972813645398187 GO:0019212 phosphatase inhibitor activity 6/2058 56/18639 0.107142857142857 0.970376926280716 0.594380960152395 0.983287177788532 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 6/2058 56/18639 0.107142857142857 0.970376926280716 0.594380960152395 0.983287177788532 GO:0170055 lipid transmembrane transporter activity 6/2058 56/18639 0.107142857142857 0.970376926280716 0.594380960152395 0.983287177788532 GO:0022829 wide pore channel activity 4/2058 37/18639 0.108108108108108 0.979119060751714 0.595408838990453 0.983388965426273 GO:0019003 GDP binding 8/2058 75/18639 0.106666666666667 0.966064139941691 0.59601717119911 0.983388965426273 GO:0019001 guanyl nucleotide binding 43/2058 400/18639 0.1075 0.973611516034985 0.598626241205361 0.985091140007241 GO:0032561 guanyl ribonucleotide binding 43/2058 400/18639 0.1075 0.973611516034985 0.598626241205361 0.985091140007241 GO:0016758 hexosyltransferase activity 21/2058 197/18639 0.106598984771574 0.965451155081322 0.602120878674777 0.986259557412891 GO:0043495 protein-membrane adaptor activity 5/2058 47/18639 0.106382978723404 0.963494820420569 0.604137783872345 0.986259557412891 GO:0000400 four-way junction DNA binding 2/2058 18/18639 0.111111111111111 1.00631681243926 0.606443026495677 0.986259557412891 GO:0000900 mRNA regulatory element binding translation repressor activity 2/2058 18/18639 0.111111111111111 1.00631681243926 0.606443026495677 0.986259557412891 GO:0008308 voltage-gated monoatomic anion channel activity 2/2058 18/18639 0.111111111111111 1.00631681243926 0.606443026495677 0.986259557412891 GO:0015373 monoatomic anion:sodium symporter activity 2/2058 18/18639 0.111111111111111 1.00631681243926 0.606443026495677 0.986259557412891 GO:0016854 racemase and epimerase activity 2/2058 18/18639 0.111111111111111 1.00631681243926 0.606443026495677 0.986259557412891 GO:0030228 lipoprotein particle receptor activity 2/2058 18/18639 0.111111111111111 1.00631681243926 0.606443026495677 0.986259557412891 GO:0099602 neurotransmitter receptor regulator activity 2/2058 18/18639 0.111111111111111 1.00631681243926 0.606443026495677 0.986259557412891 GO:0046625 sphingolipid binding 3/2058 28/18639 0.107142857142857 0.970376926280716 0.61108762147628 0.989083928753774 GO:0046875 ephrin receptor binding 3/2058 28/18639 0.107142857142857 0.970376926280716 0.61108762147628 0.989083928753774 GO:0141052 histone H3 demethylase activity 3/2058 28/18639 0.107142857142857 0.970376926280716 0.61108762147628 0.989083928753774 GO:0051536 iron-sulfur cluster binding 8/2058 76/18639 0.105263157894737 0.9533527696793 0.611417482883428 0.989083928753774 GO:0004601 peroxidase activity 6/2058 57/18639 0.105263157894737 0.9533527696793 0.612139212911664 0.989083928753774 GO:0043531 ADP binding 4/2058 38/18639 0.105263157894737 0.9533527696793 0.61705237857378 0.995734393848387 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 5/2058 48/18639 0.104166666666667 0.943422011661808 0.623281825624767 0.999999999999999 GO:0051540 metal cluster binding 8/2058 77/18639 0.103896103896104 0.94097156487827 0.626506877916621 0.999999999999999 GO:0017116 single-stranded DNA helicase activity 6/2058 58/18639 0.103448275862069 0.936915652960692 0.629455394961612 0.999999999999999 GO:0003713 transcription coactivator activity 27/2058 256/18639 0.10546875 0.95521478680758 0.630068009794761 0.999999999999999 GO:0008301 DNA binding, bending 2/2058 19/18639 0.105263157894737 0.9533527696793 0.636484911151187 0.999999999999999 GO:0008381 mechanosensitive monoatomic ion channel activity 2/2058 19/18639 0.105263157894737 0.9533527696793 0.636484911151187 0.999999999999999 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 2/2058 19/18639 0.105263157894737 0.9533527696793 0.636484911151187 0.999999999999999 GO:0070003 threonine-type peptidase activity 2/2058 19/18639 0.105263157894737 0.9533527696793 0.636484911151187 0.999999999999999 GO:0140036 ubiquitin-modified protein reader activity 2/2058 19/18639 0.105263157894737 0.9533527696793 0.636484911151187 0.999999999999999 GO:0015297 antiporter activity 14/2058 135/18639 0.103703703703704 0.939229024943311 0.639311012768964 0.999999999999999 GO:0035254 glutamate receptor binding 5/2058 49/18639 0.102040816326531 0.92416850121973 0.64185997414247 0.999999999999999 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 6/2058 59/18639 0.101694915254237 0.921035726639324 0.64631245227214 0.999999999999999 GO:0031593 polyubiquitin modification-dependent protein binding 6/2058 59/18639 0.101694915254237 0.921035726639324 0.64631245227214 0.999999999999999 GO:0016779 nucleotidyltransferase activity 14/2058 136/18639 0.102941176470588 0.932322929171669 0.650419363361945 0.999999999999999 GO:0098960 postsynaptic neurotransmitter receptor activity 7/2058 69/18639 0.101449275362319 0.918811002661934 0.650978933374089 0.999999999999999 GO:0008186 ATP-dependent activity, acting on RNA 8/2058 79/18639 0.10126582278481 0.917149499944643 0.655701461508797 0.999999999999999 GO:0015215 nucleotide transmembrane transporter activity 3/2058 30/18639 0.1 0.905685131195335 0.658622968925736 0.999999999999999 GO:0032452 histone demethylase activity 3/2058 30/18639 0.1 0.905685131195335 0.658622968925736 0.999999999999999 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 6/2058 60/18639 0.1 0.905685131195335 0.662696251210144 0.999999999999999 GO:0000339 RNA cap binding 2/2058 20/18639 0.1 0.905685131195335 0.664694308964898 0.999999999999999 GO:0005326 neurotransmitter transmembrane transporter activity 2/2058 20/18639 0.1 0.905685131195335 0.664694308964898 0.999999999999999 GO:0016408 C-acyltransferase activity 2/2058 20/18639 0.1 0.905685131195335 0.664694308964898 0.999999999999999 GO:0052745 inositol phosphate phosphatase activity 2/2058 20/18639 0.1 0.905685131195335 0.664694308964898 0.999999999999999 GO:0140939 histone H4 methyltransferase activity 2/2058 20/18639 0.1 0.905685131195335 0.664694308964898 0.999999999999999 GO:0022804 active transmembrane transporter activity 48/2058 457/18639 0.105032822757112 0.95126665858591 0.667143159493332 0.999999999999999 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 4/2058 41/18639 0.0975609756097561 0.883595249946669 0.677474671448502 0.999999999999999 GO:0043130 ubiquitin binding 10/2058 100/18639 0.1 0.905685131195335 0.6775197353637 0.999999999999999 GO:0005310 dicarboxylic acid transmembrane transporter activity 3/2058 31/18639 0.0967741935483871 0.876469481801937 0.680760322618946 0.999999999999999 GO:0008327 methyl-CpG binding 3/2058 31/18639 0.0967741935483871 0.876469481801937 0.680760322618946 0.999999999999999 GO:0016411 acylglycerol O-acyltransferase activity 3/2058 31/18639 0.0967741935483871 0.876469481801937 0.680760322618946 0.999999999999999 GO:0140457 protein demethylase activity 3/2058 31/18639 0.0967741935483871 0.876469481801937 0.680760322618946 0.999999999999999 GO:0015101 organic cation transmembrane transporter activity 8/2058 81/18639 0.0987654320987654 0.894503833279343 0.683514170265655 0.999999999999999 GO:0033192 calmodulin-dependent protein phosphatase activity 8/2058 81/18639 0.0987654320987654 0.894503833279343 0.683514170265655 0.999999999999999 GO:0140791 histone H2AXS140 phosphatase activity 8/2058 81/18639 0.0987654320987654 0.894503833279343 0.683514170265655 0.999999999999999 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 8/2058 81/18639 0.0987654320987654 0.894503833279343 0.683514170265655 0.999999999999999 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 8/2058 81/18639 0.0987654320987654 0.894503833279343 0.683514170265655 0.999999999999999 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 8/2058 81/18639 0.0987654320987654 0.894503833279343 0.683514170265655 0.999999999999999 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 8/2058 81/18639 0.0987654320987654 0.894503833279343 0.683514170265655 0.999999999999999 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 8/2058 81/18639 0.0987654320987654 0.894503833279343 0.683514170265655 0.999999999999999 GO:1990439 MAP kinase serine/threonine phosphatase activity 8/2058 81/18639 0.0987654320987654 0.894503833279343 0.683514170265655 0.999999999999999 GO:0032182 ubiquitin-like protein binding 12/2058 120/18639 0.1 0.905685131195335 0.68532064053999 0.999999999999999 GO:0003796 lysozyme activity 1/2058 10/18639 0.1 0.905685131195335 0.689722042944137 0.999999999999999 GO:0004090 carbonyl reductase (NADPH) activity 1/2058 10/18639 0.1 0.905685131195335 0.689722042944137 0.999999999999999 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 1/2058 10/18639 0.1 0.905685131195335 0.689722042944137 0.999999999999999 GO:0004445 inositol-polyphosphate 5-phosphatase activity 1/2058 10/18639 0.1 0.905685131195335 0.689722042944137 0.999999999999999 GO:0004935 adrenergic receptor activity 1/2058 10/18639 0.1 0.905685131195335 0.689722042944137 0.999999999999999 GO:0005131 growth hormone receptor binding 1/2058 10/18639 0.1 0.905685131195335 0.689722042944137 0.999999999999999 GO:0005345 purine nucleobase transmembrane transporter activity 1/2058 10/18639 0.1 0.905685131195335 0.689722042944137 0.999999999999999 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 1/2058 10/18639 0.1 0.905685131195335 0.689722042944137 0.999999999999999 GO:0008519 ammonium channel activity 1/2058 10/18639 0.1 0.905685131195335 0.689722042944137 0.999999999999999 GO:0015203 polyamine transmembrane transporter activity 1/2058 10/18639 0.1 0.905685131195335 0.689722042944137 0.999999999999999 GO:0015643 toxic substance binding 1/2058 10/18639 0.1 0.905685131195335 0.689722042944137 0.999999999999999 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1/2058 10/18639 0.1 0.905685131195335 0.689722042944137 0.999999999999999 GO:0016868 intramolecular phosphotransferase activity 1/2058 10/18639 0.1 0.905685131195335 0.689722042944137 0.999999999999999 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 1/2058 10/18639 0.1 0.905685131195335 0.689722042944137 0.999999999999999 GO:0031419 cobalamin binding 1/2058 10/18639 0.1 0.905685131195335 0.689722042944137 0.999999999999999 GO:0031720 haptoglobin binding 1/2058 10/18639 0.1 0.905685131195335 0.689722042944137 0.999999999999999 GO:0031956 medium-chain fatty acid-CoA ligase activity 1/2058 10/18639 0.1 0.905685131195335 0.689722042944137 0.999999999999999 GO:0031996 thioesterase binding 1/2058 10/18639 0.1 0.905685131195335 0.689722042944137 0.999999999999999 GO:0032356 oxidized DNA binding 1/2058 10/18639 0.1 0.905685131195335 0.689722042944137 0.999999999999999 GO:0050815 phosphoserine residue binding 1/2058 10/18639 0.1 0.905685131195335 0.689722042944137 0.999999999999999 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 1/2058 10/18639 0.1 0.905685131195335 0.689722042944137 0.999999999999999 GO:0140999 histone H3K4 trimethyltransferase activity 1/2058 10/18639 0.1 0.905685131195335 0.689722042944137 0.999999999999999 GO:0141109 transporter activator activity 1/2058 10/18639 0.1 0.905685131195335 0.689722042944137 0.999999999999999 GO:1905394 retromer complex binding 1/2058 10/18639 0.1 0.905685131195335 0.689722042944137 0.999999999999999 GO:1990763 arrestin family protein binding 1/2058 10/18639 0.1 0.905685131195335 0.689722042944137 0.999999999999999 GO:0005123 death receptor binding 2/2058 21/18639 0.0952380952380952 0.862557267805081 0.691109445511238 0.999999999999999 GO:0010314 phosphatidylinositol-5-phosphate binding 2/2058 21/18639 0.0952380952380952 0.862557267805081 0.691109445511238 0.999999999999999 GO:0019200 carbohydrate kinase activity 2/2058 21/18639 0.0952380952380952 0.862557267805081 0.691109445511238 0.999999999999999 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 2/2058 21/18639 0.0952380952380952 0.862557267805081 0.691109445511238 0.999999999999999 GO:0140312 cargo adaptor activity 2/2058 21/18639 0.0952380952380952 0.862557267805081 0.691109445511238 0.999999999999999 GO:0015179 L-amino acid transmembrane transporter activity 6/2058 62/18639 0.0967741935483871 0.876469481801937 0.694001278972604 0.999999999999999 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 8/2058 82/18639 0.0975609756097561 0.883595249946669 0.696882011949968 0.999999999999999 GO:0033549 MAP kinase phosphatase activity 8/2058 82/18639 0.0975609756097561 0.883595249946669 0.696882011949968 0.999999999999999 GO:0030515 snoRNA binding 3/2058 32/18639 0.09375 0.849079810495627 0.701811016584823 0.999999999999999 GO:0047498 calcium-dependent phospholipase A2 activity 3/2058 32/18639 0.09375 0.849079810495627 0.701811016584823 0.999999999999999 GO:0051059 NF-kappaB binding 3/2058 32/18639 0.09375 0.849079810495627 0.701811016584823 0.999999999999999 GO:0008528 G protein-coupled peptide receptor activity 12/2058 122/18639 0.0983606557377049 0.890837833962625 0.707192490185463 0.999999999999999 GO:0035403 histone H3T6 kinase activity 25/2058 247/18639 0.101214574898785 0.916685355460866 0.708387463569614 0.999999999999999 GO:0005507 copper ion binding 6/2058 63/18639 0.0952380952380952 0.862557267805081 0.708907521454758 0.999999999999999 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 8/2058 83/18639 0.0963855421686747 0.872949524043697 0.709882937343801 0.999999999999999 GO:0005544 calcium-dependent phospholipid binding 5/2058 53/18639 0.0943396226415094 0.854419935089939 0.710236451893218 0.999999999999999 GO:0016251 RNA polymerase II general transcription initiation factor activity 5/2058 53/18639 0.0943396226415094 0.854419935089939 0.710236451893218 0.999999999999999 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 5/2058 53/18639 0.0943396226415094 0.854419935089939 0.710236451893218 0.999999999999999 GO:0020037 heme binding 14/2058 142/18639 0.0985915492957746 0.89292900258695 0.713061721279056 0.999999999999999 GO:0004407 histone deacetylase activity 2/2058 22/18639 0.0909090909090909 0.823350119268487 0.715782442936016 0.999999999999999 GO:0005243 gap junction channel activity 2/2058 22/18639 0.0909090909090909 0.823350119268487 0.715782442936016 0.999999999999999 GO:0015377 chloride:monoatomic cation symporter activity 2/2058 22/18639 0.0909090909090909 0.823350119268487 0.715782442936016 0.999999999999999 GO:0033558 protein lysine deacetylase activity 2/2058 22/18639 0.0909090909090909 0.823350119268487 0.715782442936016 0.999999999999999 GO:0070034 telomerase RNA binding 2/2058 22/18639 0.0909090909090909 0.823350119268487 0.715782442936016 0.999999999999999 GO:0140035 ubiquitin-like protein reader activity 2/2058 22/18639 0.0909090909090909 0.823350119268487 0.715782442936016 0.999999999999999 GO:0046906 tetrapyrrole binding 15/2058 152/18639 0.0986842105263158 0.893768221574344 0.716040277088659 0.999999999999999 GO:0140416 transcription regulator inhibitor activity 3/2058 33/18639 0.0909090909090909 0.823350119268487 0.721785210470175 0.999999999999999 GO:0003678 DNA helicase activity 7/2058 74/18639 0.0945945945945946 0.85672917815775 0.722398541297094 0.999999999999999 GO:0017018 myosin phosphatase activity 8/2058 84/18639 0.0952380952380952 0.862557267805081 0.722512730649202 0.999999999999999 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 1/2058 11/18639 0.0909090909090909 0.823350119268487 0.72399935442736 0.999999999999999 GO:0008172 S-methyltransferase activity 1/2058 11/18639 0.0909090909090909 0.823350119268487 0.72399935442736 0.999999999999999 GO:0008503 benzodiazepine receptor activity 1/2058 11/18639 0.0909090909090909 0.823350119268487 0.72399935442736 0.999999999999999 GO:0016594 glycine binding 1/2058 11/18639 0.0909090909090909 0.823350119268487 0.72399935442736 0.999999999999999 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 1/2058 11/18639 0.0909090909090909 0.823350119268487 0.72399935442736 0.999999999999999 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 1/2058 11/18639 0.0909090909090909 0.823350119268487 0.72399935442736 0.999999999999999 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 1/2058 11/18639 0.0909090909090909 0.823350119268487 0.72399935442736 0.999999999999999 GO:0031731 CCR6 chemokine receptor binding 1/2058 11/18639 0.0909090909090909 0.823350119268487 0.72399935442736 0.999999999999999 GO:0032050 clathrin heavy chain binding 1/2058 11/18639 0.0909090909090909 0.823350119268487 0.72399935442736 0.999999999999999 GO:0032404 mismatch repair complex binding 1/2058 11/18639 0.0909090909090909 0.823350119268487 0.72399935442736 0.999999999999999 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 1/2058 11/18639 0.0909090909090909 0.823350119268487 0.72399935442736 0.999999999999999 GO:0070697 activin receptor binding 1/2058 11/18639 0.0909090909090909 0.823350119268487 0.72399935442736 0.999999999999999 GO:0070990 snRNP binding 1/2058 11/18639 0.0909090909090909 0.823350119268487 0.72399935442736 0.999999999999999 GO:0099528 G protein-coupled neurotransmitter receptor activity 1/2058 11/18639 0.0909090909090909 0.823350119268487 0.72399935442736 0.999999999999999 GO:0140031 phosphorylation-dependent protein binding 1/2058 11/18639 0.0909090909090909 0.823350119268487 0.72399935442736 0.999999999999999 GO:1990948 ubiquitin ligase inhibitor activity 1/2058 11/18639 0.0909090909090909 0.823350119268487 0.72399935442736 0.999999999999999 GO:0016790 thiolester hydrolase activity 4/2058 44/18639 0.0909090909090909 0.823350119268487 0.730915668840193 0.999999999999999 GO:0015081 sodium ion transmembrane transporter activity 16/2058 164/18639 0.0975609756097561 0.883595249946669 0.736921449622283 0.999999999999999 GO:0004602 glutathione peroxidase activity 2/2058 23/18639 0.0869565217391304 0.787552287995944 0.738775788055142 0.999999999999999 GO:0005212 structural constituent of eye lens 2/2058 23/18639 0.0869565217391304 0.787552287995944 0.738775788055142 0.999999999999999 GO:0016917 GABA receptor activity 2/2058 23/18639 0.0869565217391304 0.787552287995944 0.738775788055142 0.999999999999999 GO:0052866 phosphatidylinositol phosphate phosphatase activity 3/2058 34/18639 0.0882352941176471 0.799133939290002 0.740699617440669 0.999999999999999 GO:0004386 helicase activity 15/2058 155/18639 0.0967741935483871 0.876469481801937 0.743565519641454 0.999999999999999 GO:0015294 solute:monoatomic cation symporter activity 11/2058 116/18639 0.0948275862068965 0.858839348547301 0.747022249409575 0.999999999999999 GO:0000340 RNA 7-methylguanosine cap binding 1/2058 12/18639 0.0833333333333333 0.754737609329446 0.754491588085751 0.999999999999999 GO:0003995 acyl-CoA dehydrogenase activity 1/2058 12/18639 0.0833333333333333 0.754737609329446 0.754491588085751 0.999999999999999 GO:0004875 complement receptor activity 1/2058 12/18639 0.0833333333333333 0.754737609329446 0.754491588085751 0.999999999999999 GO:0005025 transforming growth factor beta receptor activity, type I 1/2058 12/18639 0.0833333333333333 0.754737609329446 0.754491588085751 0.999999999999999 GO:0005026 transforming growth factor beta receptor activity, type II 1/2058 12/18639 0.0833333333333333 0.754737609329446 0.754491588085751 0.999999999999999 GO:0005078 MAP-kinase scaffold activity 1/2058 12/18639 0.0833333333333333 0.754737609329446 0.754491588085751 0.999999999999999 GO:0005095 GTPase inhibitor activity 1/2058 12/18639 0.0833333333333333 0.754737609329446 0.754491588085751 0.999999999999999 GO:0005165 neurotrophin receptor binding 1/2058 12/18639 0.0833333333333333 0.754737609329446 0.754491588085751 0.999999999999999 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 1/2058 12/18639 0.0833333333333333 0.754737609329446 0.754491588085751 0.999999999999999 GO:0008504 monoamine transmembrane transporter activity 1/2058 12/18639 0.0833333333333333 0.754737609329446 0.754491588085751 0.999999999999999 GO:0016361 activin receptor activity, type I 1/2058 12/18639 0.0833333333333333 0.754737609329446 0.754491588085751 0.999999999999999 GO:0016362 activin receptor activity, type II 1/2058 12/18639 0.0833333333333333 0.754737609329446 0.754491588085751 0.999999999999999 GO:0016423 tRNA (guanine) methyltransferase activity 1/2058 12/18639 0.0833333333333333 0.754737609329446 0.754491588085751 0.999999999999999 GO:0017002 activin receptor activity 1/2058 12/18639 0.0833333333333333 0.754737609329446 0.754491588085751 0.999999999999999 GO:0035014 phosphatidylinositol 3-kinase regulator activity 1/2058 12/18639 0.0833333333333333 0.754737609329446 0.754491588085751 0.999999999999999 GO:0035251 UDP-glucosyltransferase activity 1/2058 12/18639 0.0833333333333333 0.754737609329446 0.754491588085751 0.999999999999999 GO:0042301 phosphate ion binding 1/2058 12/18639 0.0833333333333333 0.754737609329446 0.754491588085751 0.999999999999999 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 1/2058 12/18639 0.0833333333333333 0.754737609329446 0.754491588085751 0.999999999999999 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 1/2058 12/18639 0.0833333333333333 0.754737609329446 0.754491588085751 0.999999999999999 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 1/2058 12/18639 0.0833333333333333 0.754737609329446 0.754491588085751 0.999999999999999 GO:1990459 transferrin receptor binding 1/2058 12/18639 0.0833333333333333 0.754737609329446 0.754491588085751 0.999999999999999 GO:1990817 poly(A) RNA polymerase activity 1/2058 12/18639 0.0833333333333333 0.754737609329446 0.754491588085751 0.999999999999999 GO:0005343 organic acid:sodium symporter activity 3/2058 35/18639 0.0857142857142857 0.776301541024573 0.758576426098115 0.999999999999999 GO:0003724 RNA helicase activity 7/2058 77/18639 0.0909090909090909 0.823350119268487 0.760135205496764 0.999999999999999 GO:0004622 lysophospholipase activity 2/2058 24/18639 0.0833333333333333 0.754737609329446 0.76015941037654 0.999999999999999 GO:0005315 phosphate transmembrane transporter activity 2/2058 24/18639 0.0833333333333333 0.754737609329446 0.76015941037654 0.999999999999999 GO:0050699 WW domain binding 2/2058 24/18639 0.0833333333333333 0.754737609329446 0.76015941037654 0.999999999999999 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 2/2058 24/18639 0.0833333333333333 0.754737609329446 0.76015941037654 0.999999999999999 GO:0140612 DNA damage sensor activity 2/2058 24/18639 0.0833333333333333 0.754737609329446 0.76015941037654 0.999999999999999 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 4/2058 46/18639 0.0869565217391304 0.787552287995944 0.762674515969806 0.999999999999999 GO:0001653 peptide receptor activity 12/2058 128/18639 0.09375 0.849079810495627 0.766934107829615 0.999999999999999 GO:0004197 cysteine-type endopeptidase activity 8/2058 88/18639 0.0909090909090909 0.823350119268487 0.769279914217921 0.999999999999999 GO:0016651 oxidoreductase activity, acting on NAD(P)H 8/2058 88/18639 0.0909090909090909 0.823350119268487 0.769279914217921 0.999999999999999 GO:0004869 cysteine-type endopeptidase inhibitor activity 3/2058 36/18639 0.0833333333333333 0.754737609329446 0.775442326110693 0.999999999999999 GO:0016409 palmitoyltransferase activity 3/2058 36/18639 0.0833333333333333 0.754737609329446 0.775442326110693 0.999999999999999 GO:0005537 D-mannose binding 2/2058 25/18639 0.08 0.724548104956268 0.780008278513457 0.999999999999999 GO:0015296 monoatomic anion:monoatomic cation symporter activity 2/2058 25/18639 0.08 0.724548104956268 0.780008278513457 0.999999999999999 GO:0017025 TBP-class protein binding 2/2058 25/18639 0.08 0.724548104956268 0.780008278513457 0.999999999999999 GO:0047617 fatty acyl-CoA hydrolase activity 2/2058 25/18639 0.08 0.724548104956268 0.780008278513457 0.999999999999999 GO:0004465 lipoprotein lipase activity 1/2058 13/18639 0.0769230769230769 0.696680870150258 0.781616531002996 0.999999999999999 GO:0004535 poly(A)-specific ribonuclease activity 1/2058 13/18639 0.0769230769230769 0.696680870150258 0.781616531002996 0.999999999999999 GO:0008253 5'-nucleotidase activity 1/2058 13/18639 0.0769230769230769 0.696680870150258 0.781616531002996 0.999999999999999 GO:0015651 quaternary ammonium group transmembrane transporter activity 1/2058 13/18639 0.0769230769230769 0.696680870150258 0.781616531002996 0.999999999999999 GO:0019104 DNA N-glycosylase activity 1/2058 13/18639 0.0769230769230769 0.696680870150258 0.781616531002996 0.999999999999999 GO:0019855 calcium channel inhibitor activity 1/2058 13/18639 0.0769230769230769 0.696680870150258 0.781616531002996 0.999999999999999 GO:0030955 potassium ion binding 1/2058 13/18639 0.0769230769230769 0.696680870150258 0.781616531002996 0.999999999999999 GO:0043560 insulin receptor substrate binding 1/2058 13/18639 0.0769230769230769 0.696680870150258 0.781616531002996 0.999999999999999 GO:0045159 myosin II binding 1/2058 13/18639 0.0769230769230769 0.696680870150258 0.781616531002996 0.999999999999999 GO:0046975 histone H3K36 methyltransferase activity 1/2058 13/18639 0.0769230769230769 0.696680870150258 0.781616531002996 0.999999999999999 GO:0051011 microtubule minus-end binding 1/2058 13/18639 0.0769230769230769 0.696680870150258 0.781616531002996 0.999999999999999 GO:0070700 BMP receptor binding 1/2058 13/18639 0.0769230769230769 0.696680870150258 0.781616531002996 0.999999999999999 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 1/2058 13/18639 0.0769230769230769 0.696680870150258 0.781616531002996 0.999999999999999 GO:0097157 pre-mRNA intronic binding 1/2058 13/18639 0.0769230769230769 0.696680870150258 0.781616531002996 0.999999999999999 GO:0140666 annealing activity 1/2058 13/18639 0.0769230769230769 0.696680870150258 0.781616531002996 0.999999999999999 GO:1901338 catecholamine binding 1/2058 13/18639 0.0769230769230769 0.696680870150258 0.781616531002996 0.999999999999999 GO:0004679 AMP-activated protein kinase activity 24/2058 248/18639 0.0967741935483871 0.876469481801937 0.783015102106983 0.999999999999999 GO:0016835 carbon-oxygen lyase activity 7/2058 79/18639 0.0886075949367089 0.802505812451563 0.783146723220118 0.999999999999999 GO:0016829 lyase activity 19/2058 200/18639 0.095 0.860400874635568 0.789038099957285 0.999999999999999 GO:0032266 phosphatidylinositol-3-phosphate binding 4/2058 48/18639 0.0833333333333333 0.754737609329446 0.791434872894785 0.999999999999999 GO:0038187 pattern recognition receptor activity 4/2058 48/18639 0.0833333333333333 0.754737609329446 0.791434872894785 0.999999999999999 GO:0000510 H3-H4 histone complex chaperone activity 14/2058 151/18639 0.0927152317880795 0.839708068657927 0.792996729993826 0.999999999999999 GO:0140584 chromatin extrusion motor activity 14/2058 151/18639 0.0927152317880795 0.839708068657927 0.792996729993826 0.999999999999999 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 14/2058 151/18639 0.0927152317880795 0.839708068657927 0.792996729993826 0.999999999999999 GO:0140849 ATP-dependent H2AZ histone chaperone activity 14/2058 151/18639 0.0927152317880795 0.839708068657927 0.792996729993826 0.999999999999999 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 2/2058 26/18639 0.0769230769230769 0.696680870150258 0.798400436220194 0.999999999999999 GO:0008198 ferrous iron binding 2/2058 26/18639 0.0769230769230769 0.696680870150258 0.798400436220194 0.999999999999999 GO:0015216 purine nucleotide transmembrane transporter activity 2/2058 26/18639 0.0769230769230769 0.696680870150258 0.798400436220194 0.999999999999999 GO:0016289 acyl-CoA hydrolase activity 2/2058 26/18639 0.0769230769230769 0.696680870150258 0.798400436220194 0.999999999999999 GO:0015616 DNA translocase activity 14/2058 152/18639 0.0921052631578947 0.834183673469388 0.80080390637551 0.999999999999999 GO:0140674 ATP-dependent histone chaperone activity 14/2058 152/18639 0.0921052631578947 0.834183673469388 0.80080390637551 0.999999999999999 GO:0008392 arachidonate epoxygenase activity 1/2058 14/18639 0.0714285714285714 0.646917950853811 0.805745875961432 0.999999999999999 GO:0008474 palmitoyl-(protein) hydrolase activity 1/2058 14/18639 0.0714285714285714 0.646917950853811 0.805745875961432 0.999999999999999 GO:0016530 metallochaperone activity 1/2058 14/18639 0.0714285714285714 0.646917950853811 0.805745875961432 0.999999999999999 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 1/2058 14/18639 0.0714285714285714 0.646917950853811 0.805745875961432 0.999999999999999 GO:0030983 mismatched DNA binding 1/2058 14/18639 0.0714285714285714 0.646917950853811 0.805745875961432 0.999999999999999 GO:0032454 histone H3K9 demethylase activity 1/2058 14/18639 0.0714285714285714 0.646917950853811 0.805745875961432 0.999999999999999 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 1/2058 14/18639 0.0714285714285714 0.646917950853811 0.805745875961432 0.999999999999999 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 1/2058 14/18639 0.0714285714285714 0.646917950853811 0.805745875961432 0.999999999999999 GO:0061665 SUMO ligase activity 1/2058 14/18639 0.0714285714285714 0.646917950853811 0.805745875961432 0.999999999999999 GO:0061783 peptidoglycan muralytic activity 1/2058 14/18639 0.0714285714285714 0.646917950853811 0.805745875961432 0.999999999999999 GO:0098599 palmitoyl hydrolase activity 1/2058 14/18639 0.0714285714285714 0.646917950853811 0.805745875961432 0.999999999999999 GO:0098821 BMP receptor activity 1/2058 14/18639 0.0714285714285714 0.646917950853811 0.805745875961432 0.999999999999999 GO:1901474 azole transmembrane transporter activity 1/2058 14/18639 0.0714285714285714 0.646917950853811 0.805745875961432 0.999999999999999 GO:0001098 basal transcription machinery binding 5/2058 60/18639 0.0833333333333333 0.754737609329446 0.806578841679989 0.999999999999999 GO:0001099 basal RNA polymerase II transcription machinery binding 5/2058 60/18639 0.0833333333333333 0.754737609329446 0.806578841679989 0.999999999999999 GO:0061775 cohesin loader activity 14/2058 153/18639 0.0915032679738562 0.828731492597039 0.808397325896476 0.999999999999999 GO:0052689 carboxylic ester hydrolase activity 8/2058 92/18639 0.0869565217391304 0.787552287995944 0.810076849308824 0.999999999999999 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 23/2058 243/18639 0.0946502057613169 0.857232840226038 0.812561608915388 0.999999999999999 GO:0140713 histone chaperone activity 15/2058 164/18639 0.0914634146341463 0.828370546825002 0.815331359459829 0.999999999999999 GO:0004364 glutathione transferase activity 2/2058 27/18639 0.0740740740740741 0.670877874959508 0.815415410343466 0.999999999999999 GO:0005385 zinc ion transmembrane transporter activity 2/2058 27/18639 0.0740740740740741 0.670877874959508 0.815415410343466 0.999999999999999 GO:0004722 protein serine/threonine phosphatase activity 9/2058 103/18639 0.087378640776699 0.791375357355147 0.815793484987156 0.999999999999999 GO:0005253 monoatomic anion channel activity 9/2058 103/18639 0.087378640776699 0.791375357355147 0.815793484987156 0.999999999999999 GO:0015605 organophosphate ester transmembrane transporter activity 4/2058 50/18639 0.08 0.724548104956268 0.817328242888179 0.999999999999999 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 5/2058 61/18639 0.0819672131147541 0.742364861635521 0.818005931453507 0.999999999999999 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 3/2058 39/18639 0.0769230769230769 0.696680870150258 0.820291284366835 0.999999999999999 GO:0015103 inorganic anion transmembrane transporter activity 15/2058 165/18639 0.0909090909090909 0.823350119268487 0.822305279018425 0.999999999999999 GO:0004676 3-phosphoinositide-dependent protein kinase activity 23/2058 245/18639 0.0938775510204082 0.850235021122152 0.824144590813561 0.999999999999999 GO:0004711 ribosomal protein S6 kinase activity 23/2058 245/18639 0.0938775510204082 0.850235021122152 0.824144590813561 0.999999999999999 GO:0035175 histone H3S10 kinase activity 23/2058 245/18639 0.0938775510204082 0.850235021122152 0.824144590813561 0.999999999999999 GO:0035979 histone H2AXS139 kinase activity 23/2058 245/18639 0.0938775510204082 0.850235021122152 0.824144590813561 0.999999999999999 GO:0044022 histone H3S28 kinase activity 23/2058 245/18639 0.0938775510204082 0.850235021122152 0.824144590813561 0.999999999999999 GO:0044023 histone H4S1 kinase activity 23/2058 245/18639 0.0938775510204082 0.850235021122152 0.824144590813561 0.999999999999999 GO:0044024 histone H2AS1 kinase activity 23/2058 245/18639 0.0938775510204082 0.850235021122152 0.824144590813561 0.999999999999999 GO:0044025 histone H2BS14 kinase activity 23/2058 245/18639 0.0938775510204082 0.850235021122152 0.824144590813561 0.999999999999999 GO:0072354 histone H3T3 kinase activity 23/2058 245/18639 0.0938775510204082 0.850235021122152 0.824144590813561 0.999999999999999 GO:0072371 histone H2AS121 kinase activity 23/2058 245/18639 0.0938775510204082 0.850235021122152 0.824144590813561 0.999999999999999 GO:0072518 Rho-dependent protein serine/threonine kinase activity 23/2058 245/18639 0.0938775510204082 0.850235021122152 0.824144590813561 0.999999999999999 GO:0140823 histone H2BS36 kinase activity 23/2058 245/18639 0.0938775510204082 0.850235021122152 0.824144590813561 0.999999999999999 GO:0140855 histone H3S57 kinase activity 23/2058 245/18639 0.0938775510204082 0.850235021122152 0.824144590813561 0.999999999999999 GO:0140995 histone H2A kinase activity 23/2058 245/18639 0.0938775510204082 0.850235021122152 0.824144590813561 0.999999999999999 GO:0140997 histone H4 kinase activity 23/2058 245/18639 0.0938775510204082 0.850235021122152 0.824144590813561 0.999999999999999 GO:0140998 histone H2B kinase activity 23/2058 245/18639 0.0938775510204082 0.850235021122152 0.824144590813561 0.999999999999999 GO:1990244 histone H2AT120 kinase activity 23/2058 245/18639 0.0938775510204082 0.850235021122152 0.824144590813561 0.999999999999999 GO:0005254 chloride channel activity 7/2058 83/18639 0.0843373493975904 0.763830833538235 0.824148390573939 0.999999999999999 GO:0004129 cytochrome-c oxidase activity 1/2058 15/18639 0.0666666666666667 0.603790087463557 0.827210304808217 0.999999999999999 GO:0004865 protein serine/threonine phosphatase inhibitor activity 1/2058 15/18639 0.0666666666666667 0.603790087463557 0.827210304808217 0.999999999999999 GO:0008242 omega peptidase activity 1/2058 15/18639 0.0666666666666667 0.603790087463557 0.827210304808217 0.999999999999999 GO:0008252 nucleotidase activity 1/2058 15/18639 0.0666666666666667 0.603790087463557 0.827210304808217 0.999999999999999 GO:0010181 FMN binding 1/2058 15/18639 0.0666666666666667 0.603790087463557 0.827210304808217 0.999999999999999 GO:0015250 water channel activity 1/2058 15/18639 0.0666666666666667 0.603790087463557 0.827210304808217 0.999999999999999 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 1/2058 15/18639 0.0666666666666667 0.603790087463557 0.827210304808217 0.999999999999999 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 1/2058 15/18639 0.0666666666666667 0.603790087463557 0.827210304808217 0.999999999999999 GO:0030553 cGMP binding 1/2058 15/18639 0.0666666666666667 0.603790087463557 0.827210304808217 0.999999999999999 GO:0048531 beta-1,3-galactosyltransferase activity 1/2058 15/18639 0.0666666666666667 0.603790087463557 0.827210304808217 0.999999999999999 GO:0050700 CARD domain binding 1/2058 15/18639 0.0666666666666667 0.603790087463557 0.827210304808217 0.999999999999999 GO:0055105 ubiquitin-protein transferase inhibitor activity 1/2058 15/18639 0.0666666666666667 0.603790087463557 0.827210304808217 0.999999999999999 GO:0061578 K63-linked deubiquitinase activity 1/2058 15/18639 0.0666666666666667 0.603790087463557 0.827210304808217 0.999999999999999 GO:0120283 protein serine/threonine kinase binding 1/2058 15/18639 0.0666666666666667 0.603790087463557 0.827210304808217 0.999999999999999 GO:0140161 monocarboxylate:sodium symporter activity 1/2058 15/18639 0.0666666666666667 0.603790087463557 0.827210304808217 0.999999999999999 GO:0045296 cadherin binding 32/2058 334/18639 0.0958083832335329 0.867722281384752 0.827865916056659 0.999999999999999 GO:0016410 N-acyltransferase activity 8/2058 94/18639 0.0851063829787234 0.770795856336456 0.828300439485406 0.999999999999999 GO:0015399 primary active transmembrane transporter activity 15/2058 166/18639 0.0903614457831325 0.818390178790966 0.829083051511323 0.999999999999999 GO:0005048 signal sequence binding 4/2058 51/18639 0.0784313725490196 0.71034127936889 0.82924932928572 0.999999999999999 GO:0016830 carbon-carbon lyase activity 4/2058 51/18639 0.0784313725490196 0.71034127936889 0.82924932928572 0.999999999999999 GO:0004677 DNA-dependent protein kinase activity 23/2058 246/18639 0.0934959349593496 0.846778781198891 0.829739129225322 0.999999999999999 GO:0140857 histone H3T45 kinase activity 23/2058 246/18639 0.0934959349593496 0.846778781198891 0.829739129225322 0.999999999999999 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 6/2058 73/18639 0.0821917808219178 0.744398737968769 0.830558615523185 0.999999999999999 GO:0043539 protein serine/threonine kinase activator activity 6/2058 73/18639 0.0821917808219178 0.744398737968769 0.830558615523185 0.999999999999999 GO:0046966 nuclear thyroid hormone receptor binding 2/2058 28/18639 0.0714285714285714 0.646917950853811 0.831132932564019 0.999999999999999 GO:0051537 2 iron, 2 sulfur cluster binding 2/2058 28/18639 0.0714285714285714 0.646917950853811 0.831132932564019 0.999999999999999 GO:0032451 demethylase activity 3/2058 40/18639 0.075 0.679263848396501 0.833441820869896 0.999999999999999 GO:0035402 histone H3T11 kinase activity 23/2058 247/18639 0.0931174089068826 0.843350527023996 0.835203359356917 0.999999999999999 GO:0022824 transmitter-gated monoatomic ion channel activity 5/2058 63/18639 0.0793650793650794 0.718797723170901 0.839226292125355 0.999999999999999 GO:0022835 transmitter-gated channel activity 5/2058 63/18639 0.0793650793650794 0.718797723170901 0.839226292125355 0.999999999999999 GO:1901682 sulfur compound transmembrane transporter activity 5/2058 63/18639 0.0793650793650794 0.718797723170901 0.839226292125355 0.999999999999999 GO:0000149 SNARE binding 9/2058 106/18639 0.0849056603773585 0.768977941580945 0.8407716740817 0.999999999999999 GO:0140658 ATP-dependent chromatin remodeler activity 14/2058 158/18639 0.0886075949367089 0.802505812451563 0.843212775325426 0.999999999999999 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 21/2058 229/18639 0.091703056768559 0.830540950004456 0.845446962088358 0.999999999999999 GO:0010484 histone H3 acetyltransferase activity 2/2058 29/18639 0.0689655172413793 0.624610435307128 0.845631925095547 0.999999999999999 GO:0016417 S-acyltransferase activity 2/2058 29/18639 0.0689655172413793 0.624610435307128 0.845631925095547 0.999999999999999 GO:0017080 sodium channel regulator activity 3/2058 41/18639 0.0731707317073171 0.662696437460001 0.845755016876848 0.999999999999999 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 1/2058 16/18639 0.0625 0.566053206997085 0.846304011461175 0.999999999999999 GO:0004708 MAP kinase kinase activity 1/2058 16/18639 0.0625 0.566053206997085 0.846304011461175 0.999999999999999 GO:0005149 interleukin-1 receptor binding 1/2058 16/18639 0.0625 0.566053206997085 0.846304011461175 0.999999999999999 GO:0008391 arachidonate monooxygenase activity 1/2058 16/18639 0.0625 0.566053206997085 0.846304011461175 0.999999999999999 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 1/2058 16/18639 0.0625 0.566053206997085 0.846304011461175 0.999999999999999 GO:0016675 oxidoreductase activity, acting on a heme group of donors 1/2058 16/18639 0.0625 0.566053206997085 0.846304011461175 0.999999999999999 GO:0017070 U6 snRNA binding 1/2058 16/18639 0.0625 0.566053206997085 0.846304011461175 0.999999999999999 GO:0022841 potassium ion leak channel activity 1/2058 16/18639 0.0625 0.566053206997085 0.846304011461175 0.999999999999999 GO:0022858 alanine transmembrane transporter activity 1/2058 16/18639 0.0625 0.566053206997085 0.846304011461175 0.999999999999999 GO:0030275 LRR domain binding 1/2058 16/18639 0.0625 0.566053206997085 0.846304011461175 0.999999999999999 GO:0031435 mitogen-activated protein kinase kinase kinase binding 1/2058 16/18639 0.0625 0.566053206997085 0.846304011461175 0.999999999999999 GO:0140296 general transcription initiation factor binding 4/2058 53/18639 0.0754716981132075 0.683535948071951 0.851150909197926 0.999999999999999 GO:0008509 monoatomic anion transmembrane transporter activity 13/2058 149/18639 0.087248322147651 0.790195080908682 0.851215977814447 0.999999999999999 GO:0003712 transcription coregulator activity 48/2058 495/18639 0.096969696969697 0.878240127219719 0.851303597164793 0.999999999999999 GO:0003689 DNA clamp loader activity 14/2058 160/18639 0.0875 0.792474489795918 0.855707923894848 0.999999999999999 GO:0043175 RNA polymerase core enzyme binding 3/2058 42/18639 0.0714285714285714 0.646917950853811 0.857269330882577 0.999999999999999 GO:0035925 mRNA 3'-UTR AU-rich region binding 2/2058 30/18639 0.0666666666666667 0.603790087463557 0.858989707679104 0.999999999999999 GO:0051721 protein phosphatase 2A binding 2/2058 30/18639 0.0666666666666667 0.603790087463557 0.858989707679104 0.999999999999999 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 11/2058 130/18639 0.0846153846153846 0.766348957165284 0.862441621935669 0.999999999999999 GO:0009881 photoreceptor activity 1/2058 17/18639 0.0588235294117647 0.532755959526668 0.86328872629836 0.999999999999999 GO:0015347 sodium-independent organic anion transmembrane transporter activity 1/2058 17/18639 0.0588235294117647 0.532755959526668 0.86328872629836 0.999999999999999 GO:0016805 dipeptidase activity 1/2058 17/18639 0.0588235294117647 0.532755959526668 0.86328872629836 0.999999999999999 GO:0031489 myosin V binding 1/2058 17/18639 0.0588235294117647 0.532755959526668 0.86328872629836 0.999999999999999 GO:0036041 long-chain fatty acid binding 1/2058 17/18639 0.0588235294117647 0.532755959526668 0.86328872629836 0.999999999999999 GO:0070402 NADPH binding 1/2058 17/18639 0.0588235294117647 0.532755959526668 0.86328872629836 0.999999999999999 GO:0070492 oligosaccharide binding 1/2058 17/18639 0.0588235294117647 0.532755959526668 0.86328872629836 0.999999999999999 GO:0005452 solute:inorganic anion antiporter activity 2/2058 31/18639 0.0645161290322581 0.584312987867958 0.871281389407391 0.999999999999999 GO:0005372 water transmembrane transporter activity 1/2058 18/18639 0.0555555555555556 0.503158406219631 0.878397296874989 0.999999999999999 GO:0015172 acidic amino acid transmembrane transporter activity 1/2058 18/18639 0.0555555555555556 0.503158406219631 0.878397296874989 0.999999999999999 GO:0015280 ligand-gated sodium channel activity 1/2058 18/18639 0.0555555555555556 0.503158406219631 0.878397296874989 0.999999999999999 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 1/2058 18/18639 0.0555555555555556 0.503158406219631 0.878397296874989 0.999999999999999 GO:0017075 syntaxin-1 binding 1/2058 18/18639 0.0555555555555556 0.503158406219631 0.878397296874989 0.999999999999999 GO:0022851 GABA-gated chloride ion channel activity 1/2058 18/18639 0.0555555555555556 0.503158406219631 0.878397296874989 0.999999999999999 GO:0032393 MHC class I receptor activity 1/2058 18/18639 0.0555555555555556 0.503158406219631 0.878397296874989 0.999999999999999 GO:0035615 clathrin adaptor activity 1/2058 18/18639 0.0555555555555556 0.503158406219631 0.878397296874989 0.999999999999999 GO:0098641 cadherin binding involved in cell-cell adhesion 1/2058 18/18639 0.0555555555555556 0.503158406219631 0.878397296874989 0.999999999999999 GO:0030170 pyridoxal phosphate binding 4/2058 56/18639 0.0714285714285714 0.646917950853811 0.879506602165834 0.999999999999999 GO:0015370 solute:sodium symporter activity 6/2058 79/18639 0.0759493670886076 0.687862124958483 0.881466817075396 0.999999999999999 GO:0043425 bHLH transcription factor binding 2/2058 32/18639 0.0625 0.566053206997085 0.882579414262229 0.999999999999999 GO:0140142 nucleocytoplasmic carrier activity 2/2058 32/18639 0.0625 0.566053206997085 0.882579414262229 0.999999999999999 GO:0042393 histone binding 22/2058 247/18639 0.0890688259109312 0.806683112805562 0.883394732045932 0.999999999999999 GO:0140223 general transcription initiation factor activity 5/2058 68/18639 0.0735294117647059 0.665944949408335 0.883479428347289 0.999999999999999 GO:0015932 nucleobase-containing compound transmembrane transporter activity 4/2058 57/18639 0.0701754385964912 0.635568513119534 0.887856498048957 0.999999999999999 GO:0070279 vitamin B6 binding 4/2058 57/18639 0.0701754385964912 0.635568513119534 0.887856498048957 0.999999999999999 GO:0008080 N-acetyltransferase activity 5/2058 69/18639 0.072463768115942 0.656293573329953 0.89095646088414 0.999999999999999 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 1/2058 19/18639 0.0526315789473684 0.47667638483965 0.891836873859644 0.999999999999999 GO:0004890 GABA-A receptor activity 1/2058 19/18639 0.0526315789473684 0.47667638483965 0.891836873859644 0.999999999999999 GO:0022840 leak channel activity 1/2058 19/18639 0.0526315789473684 0.47667638483965 0.891836873859644 0.999999999999999 GO:0022842 narrow pore channel activity 1/2058 19/18639 0.0526315789473684 0.47667638483965 0.891836873859644 0.999999999999999 GO:0031420 alkali metal ion binding 1/2058 19/18639 0.0526315789473684 0.47667638483965 0.891836873859644 0.999999999999999 GO:0042800 histone H3K4 methyltransferase activity 1/2058 19/18639 0.0526315789473684 0.47667638483965 0.891836873859644 0.999999999999999 GO:0046527 glucosyltransferase activity 1/2058 19/18639 0.0526315789473684 0.47667638483965 0.891836873859644 0.999999999999999 GO:0042923 neuropeptide binding 2/2058 33/18639 0.0606060606060606 0.548900079512324 0.892953233861717 0.999999999999999 GO:0140597 protein carrier chaperone 16/2058 188/18639 0.0851063829787234 0.770795856336456 0.894108485942206 0.999999999999999 GO:0008094 ATP-dependent activity, acting on DNA 18/2058 210/18639 0.0857142857142857 0.776301541024573 0.899613209961755 0.999999999999999 GO:0008175 tRNA methyltransferase activity 2/2058 34/18639 0.0588235294117647 0.532755959526668 0.902469084888032 0.999999999999999 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 2/2058 34/18639 0.0588235294117647 0.532755959526668 0.902469084888032 0.999999999999999 GO:0051427 hormone receptor binding 2/2058 34/18639 0.0588235294117647 0.532755959526668 0.902469084888032 0.999999999999999 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 1/2058 20/18639 0.05 0.452842565597668 0.90379174569621 0.999999999999999 GO:0030742 GTP-dependent protein binding 1/2058 20/18639 0.05 0.452842565597668 0.90379174569621 0.999999999999999 GO:0043024 ribosomal small subunit binding 1/2058 20/18639 0.05 0.452842565597668 0.90379174569621 0.999999999999999 GO:0140664 ATP-dependent DNA damage sensor activity 1/2058 20/18639 0.05 0.452842565597668 0.90379174569621 0.999999999999999 GO:0061733 protein-lysine-acetyltransferase activity 3/2058 47/18639 0.0638297872340425 0.578096892252342 0.904198333669492 0.999999999999999 GO:0010485 histone H4 acetyltransferase activity 2/2058 35/18639 0.0571428571428571 0.517534360683049 0.911189852087421 0.999999999999999 GO:0005248 voltage-gated sodium channel activity 1/2058 21/18639 0.0476190476190476 0.431278633902541 0.914425860705459 0.999999999999999 GO:0015125 bile acid transmembrane transporter activity 1/2058 21/18639 0.0476190476190476 0.431278633902541 0.914425860705459 0.999999999999999 GO:0035613 RNA stem-loop binding 1/2058 21/18639 0.0476190476190476 0.431278633902541 0.914425860705459 0.999999999999999 GO:0051428 peptide hormone receptor binding 1/2058 21/18639 0.0476190476190476 0.431278633902541 0.914425860705459 0.999999999999999 GO:1904047 S-adenosyl-L-methionine binding 1/2058 21/18639 0.0476190476190476 0.431278633902541 0.914425860705459 0.999999999999999 GO:0019905 syntaxin binding 4/2058 61/18639 0.0655737704918033 0.593891889308417 0.916391556156279 0.999999999999999 GO:0000993 RNA polymerase II complex binding 2/2058 36/18639 0.0555555555555556 0.503158406219631 0.919175000674287 0.999999999999999 GO:0004190 aspartic-type endopeptidase activity 2/2058 36/18639 0.0555555555555556 0.503158406219631 0.919175000674287 0.999999999999999 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 2/2058 36/18639 0.0555555555555556 0.503158406219631 0.919175000674287 0.999999999999999 GO:0030594 neurotransmitter receptor activity 7/2058 97/18639 0.0721649484536082 0.653587208079108 0.921592572220134 0.999999999999999 GO:0008649 rRNA methyltransferase activity 1/2058 22/18639 0.0454545454545455 0.411675059634243 0.923885071075432 0.999999999999999 GO:0032931 histone H3K56 acetyltransferase activity 1/2058 22/18639 0.0454545454545455 0.411675059634243 0.923885071075432 0.999999999999999 GO:0033691 sialic acid binding 1/2058 22/18639 0.0454545454545455 0.411675059634243 0.923885071075432 0.999999999999999 GO:0043992 histone H3K9 acetyltransferase activity 1/2058 22/18639 0.0454545454545455 0.411675059634243 0.923885071075432 0.999999999999999 GO:0043993 histone H3K18 acetyltransferase activity 1/2058 22/18639 0.0454545454545455 0.411675059634243 0.923885071075432 0.999999999999999 GO:0043994 histone H3K23 acetyltransferase activity 1/2058 22/18639 0.0454545454545455 0.411675059634243 0.923885071075432 0.999999999999999 GO:0043999 histone H2AK5 acetyltransferase activity 1/2058 22/18639 0.0454545454545455 0.411675059634243 0.923885071075432 0.999999999999999 GO:0044012 histone H2AK9 acetyltransferase activity 1/2058 22/18639 0.0454545454545455 0.411675059634243 0.923885071075432 0.999999999999999 GO:0044014 histone H2BK5 acetyltransferase activity 1/2058 22/18639 0.0454545454545455 0.411675059634243 0.923885071075432 0.999999999999999 GO:0044015 histone H2BK12 acetyltransferase activity 1/2058 22/18639 0.0454545454545455 0.411675059634243 0.923885071075432 0.999999999999999 GO:0044016 histone H3K4 acetyltransferase activity 1/2058 22/18639 0.0454545454545455 0.411675059634243 0.923885071075432 0.999999999999999 GO:0044017 histone H3K27 acetyltransferase activity 1/2058 22/18639 0.0454545454545455 0.411675059634243 0.923885071075432 0.999999999999999 GO:0044018 histone H3K36 acetyltransferase activity 1/2058 22/18639 0.0454545454545455 0.411675059634243 0.923885071075432 0.999999999999999 GO:0046972 histone H4K16 acetyltransferase activity 1/2058 22/18639 0.0454545454545455 0.411675059634243 0.923885071075432 0.999999999999999 GO:0140517 protein-RNA adaptor activity 1/2058 22/18639 0.0454545454545455 0.411675059634243 0.923885071075432 0.999999999999999 GO:0140908 histone H3K122 acetyltransferase activity 1/2058 22/18639 0.0454545454545455 0.411675059634243 0.923885071075432 0.999999999999999 GO:0019213 deacetylase activity 2/2058 37/18639 0.0540540540540541 0.489559530375857 0.926480564495802 0.999999999999999 GO:0070001 aspartic-type peptidase activity 2/2058 37/18639 0.0540540540540541 0.489559530375857 0.926480564495802 0.999999999999999 GO:0140104 molecular carrier activity 21/2058 249/18639 0.0843373493975904 0.763830833538235 0.927158442956606 0.999999999999999 GO:0015108 chloride transmembrane transporter activity 9/2058 121/18639 0.0743801652892562 0.673650097583307 0.928191586431712 0.999999999999999 GO:0005272 sodium channel activity 3/2058 51/18639 0.0588235294117647 0.532755959526668 0.931157940065771 0.999999999999999 GO:0016597 amino acid binding 3/2058 51/18639 0.0588235294117647 0.532755959526668 0.931157940065771 0.999999999999999 GO:0000295 adenine nucleotide transmembrane transporter activity 1/2058 23/18639 0.0434782608695652 0.393776143997972 0.932299129394536 0.999999999999999 GO:0003887 DNA-directed DNA polymerase activity 1/2058 23/18639 0.0434782608695652 0.393776143997972 0.932299129394536 0.999999999999999 GO:0005283 amino acid:sodium symporter activity 1/2058 23/18639 0.0434782608695652 0.393776143997972 0.932299129394536 0.999999999999999 GO:0008171 O-methyltransferase activity 1/2058 23/18639 0.0434782608695652 0.393776143997972 0.932299129394536 0.999999999999999 GO:0044013 histone H2B acetyltransferase activity 1/2058 23/18639 0.0434782608695652 0.393776143997972 0.932299129394536 0.999999999999999 GO:0140102 catalytic activity, acting on a rRNA 1/2058 23/18639 0.0434782608695652 0.393776143997972 0.932299129394536 0.999999999999999 GO:0000146 microfilament motor activity 2/2058 38/18639 0.0526315789473684 0.47667638483965 0.93315917847796 0.999999999999999 GO:0160215 deacylase activity 4/2058 65/18639 0.0615384615384615 0.557344696120206 0.938250885781436 0.999999999999999 GO:0005540 hyaluronic acid binding 1/2058 24/18639 0.0416666666666667 0.377368804664723 0.939783465004014 0.999999999999999 GO:0042625 ATPase-coupled ion transmembrane transporter activity 1/2058 24/18639 0.0416666666666667 0.377368804664723 0.939783465004014 0.999999999999999 GO:0043998 histone H2A acetyltransferase activity 1/2058 24/18639 0.0416666666666667 0.377368804664723 0.939783465004014 0.999999999999999 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 1/2058 24/18639 0.0416666666666667 0.377368804664723 0.939783465004014 0.999999999999999 GO:0046961 proton-transporting ATPase activity, rotational mechanism 1/2058 24/18639 0.0416666666666667 0.377368804664723 0.939783465004014 0.999999999999999 GO:0048027 mRNA 5'-UTR binding 1/2058 24/18639 0.0416666666666667 0.377368804664723 0.939783465004014 0.999999999999999 GO:0034212 protein N-acetyltransferase activity 3/2058 53/18639 0.0566037735849057 0.512651961053963 0.941840848201777 0.999999999999999 GO:0004532 RNA exonuclease activity 2/2058 40/18639 0.05 0.452842565597668 0.944829531246016 0.999999999999999 GO:0008139 nuclear localization sequence binding 1/2058 25/18639 0.04 0.362274052478134 0.946440764441121 0.999999999999999 GO:0017056 structural constituent of nuclear pore 1/2058 25/18639 0.04 0.362274052478134 0.946440764441121 0.999999999999999 GO:0019706 protein-cysteine S-palmitoyltransferase activity 1/2058 25/18639 0.04 0.362274052478134 0.946440764441121 0.999999999999999 GO:0019707 protein-cysteine S-acyltransferase activity 1/2058 25/18639 0.04 0.362274052478134 0.946440764441121 0.999999999999999 GO:0015175 neutral L-amino acid transmembrane transporter activity 2/2058 41/18639 0.0487804878048781 0.441797624973334 0.94991027557264 0.999999999999999 GO:0009055 electron transfer activity 8/2058 116/18639 0.0689655172413793 0.624610435307128 0.950702661720928 0.999999999999999 GO:0031490 chromatin DNA binding 9/2058 128/18639 0.0703125 0.63680985787172 0.952173998564497 0.999999999999999 GO:0097602 cullin family protein binding 1/2058 26/18639 0.0384615384615385 0.348340435075129 0.952362377569958 0.999999999999999 GO:0004402 histone acetyltransferase activity 2/2058 42/18639 0.0476190476190476 0.431278633902541 0.954542322807143 0.999999999999999 GO:0015252 proton channel activity 1/2058 27/18639 0.037037037037037 0.335438937479754 0.957629568617131 0.999999999999999 GO:0035255 ionotropic glutamate receptor binding 1/2058 27/18639 0.037037037037037 0.335438937479754 0.957629568617131 0.999999999999999 GO:0004712 protein serine/threonine/tyrosine kinase activity 2/2058 43/18639 0.0465116279069767 0.421248898230389 0.958762758464675 0.999999999999999 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 2/2058 43/18639 0.0465116279069767 0.421248898230389 0.958762758464675 0.999999999999999 GO:0008234 cysteine-type peptidase activity 14/2058 187/18639 0.0748663101604278 0.678053039397577 0.959327520928493 0.999999999999999 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 3/2058 58/18639 0.0517241379310345 0.468457826480346 0.962183145855485 0.999999999999999 GO:0016866 intramolecular transferase activity 1/2058 28/18639 0.0357142857142857 0.323458975426905 0.96231462921169 0.999999999999999 GO:0036408 histone H3K14 acetyltransferase activity 1/2058 28/18639 0.0357142857142857 0.323458975426905 0.96231462921169 0.999999999999999 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 1/2058 28/18639 0.0357142857142857 0.323458975426905 0.96231462921169 0.999999999999999 GO:0004540 RNA nuclease activity 8/2058 121/18639 0.0661157024793388 0.598800086740717 0.964005292599182 0.999999999999999 GO:0036002 pre-mRNA binding 3/2058 59/18639 0.0508474576271186 0.460517863319662 0.965351030816913 0.999999999999999 GO:0008170 N-methyltransferase activity 6/2058 98/18639 0.0612244897959184 0.554501100731838 0.966428442504836 0.999999999999999 GO:0005416 amino acid:monoatomic cation symporter activity 1/2058 29/18639 0.0344827586206897 0.312305217653564 0.96648186864441 0.999999999999999 GO:0106222 lncRNA binding 1/2058 29/18639 0.0344827586206897 0.312305217653564 0.96648186864441 0.999999999999999 GO:0004521 RNA endonuclease activity 4/2058 73/18639 0.0547945205479452 0.496265825312512 0.967142993228322 0.999999999999999 GO:0043995 histone H4K5 acetyltransferase activity 1/2058 30/18639 0.0333333333333333 0.301895043731778 0.970188494884593 0.999999999999999 GO:0043996 histone H4K8 acetyltransferase activity 1/2058 30/18639 0.0333333333333333 0.301895043731778 0.970188494884593 0.999999999999999 GO:0043997 histone H4K12 acetyltransferase activity 1/2058 30/18639 0.0333333333333333 0.301895043731778 0.970188494884593 0.999999999999999 GO:0046982 protein heterodimerization activity 30/2058 369/18639 0.0813008130081301 0.736329374955557 0.974342326344093 0.999999999999999 GO:0008188 neuropeptide receptor activity 2/2058 48/18639 0.0416666666666667 0.377368804664723 0.97480696817861 0.999999999999999 GO:0016755 aminoacyltransferase activity 42/2058 496/18639 0.0846774193548387 0.766910796576695 0.976243257671842 0.999999999999999 GO:0031369 translation initiation factor binding 1/2058 32/18639 0.03125 0.283026603498542 0.976417849501734 0.999999999999999 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1/2058 32/18639 0.03125 0.283026603498542 0.976417849501734 0.999999999999999 GO:0061659 ubiquitin-like protein ligase activity 30/2058 372/18639 0.0806451612903226 0.730391234834948 0.977306803977329 0.999999999999999 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 5/2058 91/18639 0.0549450549450549 0.49762919296447 0.977839781706843 0.999999999999999 GO:0019787 ubiquitin-like protein transferase activity 40/2058 479/18639 0.0835073068893528 0.756313261958526 0.979243069917857 0.999999999999999 GO:0061630 ubiquitin protein ligase activity 28/2058 353/18639 0.0793201133144476 0.718390472336243 0.979339358528803 0.999999999999999 GO:0019843 rRNA binding 3/2058 65/18639 0.0461538461538462 0.418008522090155 0.979680426503416 0.999999999999999 GO:0016798 hydrolase activity, acting on glycosyl bonds 8/2058 130/18639 0.0615384615384615 0.557344696120206 0.980057945350159 0.999999999999999 GO:0022853 active monoatomic ion transmembrane transporter activity 7/2058 118/18639 0.0593220338983051 0.537270840539606 0.980438421774528 0.999999999999999 GO:0000049 tRNA binding 4/2058 80/18639 0.05 0.452842565597668 0.981519139355993 0.999999999999999 GO:0008173 RNA methyltransferase activity 3/2058 67/18639 0.0447761194029851 0.405530655759105 0.983044184543352 0.999999999999999 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 3/2058 67/18639 0.0447761194029851 0.405530655759105 0.983044184543352 0.999999999999999 GO:0000175 3'-5'-RNA exonuclease activity 1/2058 35/18639 0.0285714285714286 0.258767180341524 0.983409445821043 0.999999999999999 GO:0016229 steroid dehydrogenase activity 1/2058 35/18639 0.0285714285714286 0.258767180341524 0.983409445821043 0.999999999999999 GO:0034061 DNA polymerase activity 1/2058 35/18639 0.0285714285714286 0.258767180341524 0.983409445821043 0.999999999999999 GO:0005484 SNAP receptor activity 1/2058 36/18639 0.0277777777777778 0.251579203109815 0.985244715682379 0.999999999999999 GO:0055106 ubiquitin-protein transferase regulator activity 1/2058 36/18639 0.0277777777777778 0.251579203109815 0.985244715682379 0.999999999999999 GO:0016279 protein-lysine N-methyltransferase activity 3/2058 69/18639 0.0434782608695652 0.393776143997972 0.985871045488167 0.999999999999999 GO:0004527 exonuclease activity 4/2058 84/18639 0.0476190476190476 0.431278633902541 0.986810632336427 0.999999999999999 GO:0030280 structural constituent of skin epidermis 1/2058 37/18639 0.027027027027027 0.244779765187928 0.98687705321534 0.999999999999999 GO:0016278 lysine N-methyltransferase activity 3/2058 70/18639 0.0428571428571429 0.388150770512287 0.98710903784725 0.999999999999999 GO:0043022 ribosome binding 6/2058 112/18639 0.0535714285714286 0.485188463140358 0.988020678175125 0.999999999999999 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 1/2058 38/18639 0.0263157894736842 0.238338192419825 0.988328887667701 0.999999999999999 GO:0042162 telomeric DNA binding 1/2058 38/18639 0.0263157894736842 0.238338192419825 0.988328887667701 0.999999999999999 GO:0043021 ribonucleoprotein complex binding 11/2058 177/18639 0.0621468926553672 0.562855166279587 0.990103443199182 0.999999999999999 GO:0003684 damaged DNA binding 3/2058 74/18639 0.0405405405405405 0.367169647781893 0.991095730813066 0.999999999999999 GO:0031491 nucleosome binding 3/2058 74/18639 0.0405405405405405 0.367169647781893 0.991095730813066 0.999999999999999 GO:0035064 methylated histone binding 3/2058 74/18639 0.0405405405405405 0.367169647781893 0.991095730813066 0.999999999999999 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 10/2058 167/18639 0.0598802395209581 0.54232642586547 0.991391064258282 0.999999999999999 GO:0004842 ubiquitin-protein transferase activity 35/2058 449/18639 0.0779510022271715 0.705990636789237 0.991646505952317 0.999999999999999 GO:0004812 aminoacyl-tRNA ligase activity 1/2058 41/18639 0.024390243902439 0.220898812486667 0.991790107593684 0.999999999999999 GO:0008227 G protein-coupled amine receptor activity 1/2058 41/18639 0.024390243902439 0.220898812486667 0.991790107593684 0.999999999999999 GO:0016875 ligase activity, forming carbon-oxygen bonds 1/2058 41/18639 0.024390243902439 0.220898812486667 0.991790107593684 0.999999999999999 GO:0008168 methyltransferase activity 13/2058 204/18639 0.0637254901960784 0.577152289487223 0.991847282020296 0.999999999999999 GO:0140034 methylation-dependent protein binding 3/2058 76/18639 0.0394736842105263 0.357507288629738 0.992613027336494 0.999999999999999 GO:0031492 nucleosomal DNA binding 1/2058 42/18639 0.0238095238095238 0.21563931695127 0.992698590149454 0.999999999999999 GO:0003954 NADH dehydrogenase activity 1/2058 44/18639 0.0227272727272727 0.205837529817122 0.994225205507396 0.999999999999999 GO:0140030 modification-dependent protein binding 10/2058 173/18639 0.0578034682080925 0.523517416875916 0.994249866795221 0.999999999999999 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 6/2058 122/18639 0.0491803278688525 0.445418916981312 0.994495155279674 0.999999999999999 GO:0140767 enzyme-substrate adaptor activity 7/2058 139/18639 0.0503597122302158 0.456100425781824 0.995846534911546 0.999999999999999 GO:0016741 transferase activity, transferring one-carbon groups 13/2058 215/18639 0.0604651162790698 0.547623567699505 0.995905139595499 0.999999999999999 GO:0140938 histone H3 methyltransferase activity 1/2058 47/18639 0.0212765957446809 0.192698964084114 0.995938285023819 0.999999999999999 GO:0019783 ubiquitin-like protein peptidase activity 6/2058 127/18639 0.047244094488189 0.427882739147402 0.996309951849735 0.999999999999999 GO:0042054 histone methyltransferase activity 2/2058 67/18639 0.0298507462686567 0.27035377050607 0.996369515528794 0.999999999999999 GO:0101005 deubiquitinase activity 5/2058 115/18639 0.0434782608695652 0.393776143997972 0.996870179955521 0.999999999999999 GO:0004518 nuclease activity 12/2058 209/18639 0.0574162679425837 0.520010601643255 0.99728747152773 0.999999999999999 GO:0015078 proton transmembrane transporter activity 10/2058 185/18639 0.0540540540540541 0.489559530375857 0.997506965807036 0.999999999999999 GO:0017069 snRNA binding 1/2058 54/18639 0.0185185185185185 0.167719468739877 0.998213466645421 0.999999999999999 GO:0004843 cysteine-type deubiquitinase activity 4/2058 108/18639 0.037037037037037 0.335438937479754 0.998428832481302 0.999999999999999 GO:0008276 protein methyltransferase activity 3/2058 95/18639 0.0315789473684211 0.28600583090379 0.998809323463097 0.999999999999999 GO:0008408 3'-5' exonuclease activity 1/2058 58/18639 0.0172413793103448 0.156152608826782 0.998882829359016 0.999999999999999 GO:0004519 endonuclease activity 5/2058 127/18639 0.0393700787401575 0.356568949289502 0.998893586132479 0.999999999999999 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1/2058 60/18639 0.0166666666666667 0.150947521865889 0.99911660234575 0.999999999999999 GO:0140097 catalytic activity, acting on DNA 21/2058 336/18639 0.0625 0.566053206997085 0.999117877110294 0.999999999999999 GO:0005179 hormone activity 5/2058 132/18639 0.0378787878787879 0.343062549695203 0.999289577639263 0.999999999999999 GO:0140101 catalytic activity, acting on a tRNA 5/2058 139/18639 0.0359712230215827 0.325786018415588 0.999621200207074 0.999999999999999 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 1/2058 68/18639 0.0147058823529412 0.133188989881667 0.999654707887416 0.999999999999999 GO:0140098 catalytic activity, acting on RNA 21/2058 387/18639 0.0542635658914729 0.491457047935453 0.999965494946232 0.999999999999999 GO:0003735 structural constituent of ribosome 5/2058 175/18639 0.0285714285714286 0.258767180341524 0.999986909457721 0.999999999999999 GO:0003730 mRNA 3'-UTR binding 10/2058 262/18639 0.0381679389312977 0.345681347784479 0.999994150083501 0.999999999999999 GO:0030371 translation repressor activity 3/2058 329/18639 0.00911854103343465 0.0825852703217631 0.999999999999988 0.999999999999999 GO:0045182 translation regulator activity 3/2058 356/18639 0.00842696629213483 0.076321780718708 0.999999999999999 0.999999999999999