category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	11/111	138/9376	6.73299386342865	MT-ATP8/MT-ATP6/MT-ND4L/MT-ND2/MT-ND1/MT-CO1/MT-ND4/MT-CYB/MT-CO2/MT-ND5/ATP6V1E2	7.42602585422399
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	12/111	227/9376	4.46529348731992	MT-ATP8/MT-ATP6/MT-ND4L/MT-ND2/MT-ND1/MT-CO1/MT-ND4/MT-CYB/MT-CO2/MT-ND5/SLC26A2/PLD1	5.78482936266811
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	12/111	235/9376	4.31328349626222	MT-ATP8/MT-ATP6/MT-ND4L/MT-ND2/MT-ND1/MT-CO1/MT-ND4/MT-CYB/MT-CO2/MT-ND5/SLC25A29/NDUFAF6	5.63015160852236
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	13/111	275/9376	3.99305487305487	MT-ATP8/MT-ATP6/MT-ND4L/MT-ND2/MT-ND1/MT-CO1/HSPA1B/MT-ND4/MT-CYB/MT-CO2/MT-ND5/HSPA1A/STIP1	5.51392538041631
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	11/111	205/9376	4.53245440562514	MT-ATP8/MT-ATP6/MT-ND4L/MT-ND2/MT-ND1/MT-CO1/MT-ND4/MT-CYB/MT-CO2/MT-ND5/GAPDH	5.59718374959902
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	5/111	41/9376	10.3010327400571	BRCA1/ATM/XRCC2/SYCP3/EME1	6.53266452294862
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	11/111	298/9376	3.11796360118508	CD40LG/IL7R/CXCL14/CD4/IFNAR2/IL23A/CCL20/IL32/TNFSF10/IL18R1/TNFSF11	4.06682936487418
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	4/111	38/9376	8.891417733523	CD3E/CD40LG/IL7R/CD4	5.3351214802279
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	11/111	308/9376	3.01673101673102	MT-ATP8/MT-ATP6/MT-ND4L/MT-ND2/MT-ND1/MT-CO1/MT-ND4/MT-CYB/MT-CO2/GPX3/MT-ND5	3.93905455705782
Human Diseases	Infectious disease: viral	hsa05162	Measles	7/111	136/9376	4.34764175940647	CD3E/HSPA1B/HSPA1A/CCND2/IFNAR2/SLAMF1/EIF3H	4.30424378519092
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	6/111	100/9376	5.06810810810811	CD3E/IL7R/CD4/CD59/CD2/CD7	4.4764787926808
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	10/111	268/9376	3.15180852494285	MT-ATP8/MT-ATP6/MT-ND4L/MT-ND2/MT-ND1/MT-CO1/MT-ND4/MT-CYB/MT-CO2/MT-ND5	3.91186560222144
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	11/111	368/9376	2.52487269878574	MT-ATP8/MT-ATP6/MT-ND4L/MT-ND2/MT-ND1/MT-CO1/MT-ND4/MT-CYB/MT-CO2/GPX3/MT-ND5	3.26638765288832
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	6/111	133/9376	3.81060760008128	IL7R/ATM/SGK1/CCND2/TNFSF10/S1PR4	3.57309016905021
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	11/111	388/9376	2.39472462152874	MT-ATP8/MT-ATP6/MT-ND4L/MT-ND2/MT-ND1/MT-CO1/MT-ND4/MT-CYB/MT-CO2/MT-ND5/GAPDH	3.07112302758611
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	5/111	115/9376	3.67254210732472	VDR/SGK1/SLC34A2/TNFSF11/PLD1	3.15623222987217
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	4/111	82/9376	4.12041309602285	HSPA1B/CD4/HSPA4/HSPA1A	3.1062907241083
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	4/111	95/9376	3.5565670934092	IL23A/ATP6V1E2/CCL20/TNFSF11	2.74123347553622
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	11/111	480/9376	1.93573573573574	MT-ATP8/MT-ATP6/MT-ND4L/MT-ND2/MT-ND1/MT-CO1/MT-ND4/MT-CYB/MT-CO2/GPX3/MT-ND5	2.30356707669409
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	4/111	100/9376	3.37873873873874	CXCL14/CCL20/TNFSF10/IL18R1	2.61752471525254
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	5/111	149/9376	2.83451236471371	MT-ND4L/MT-ND2/MT-ND1/MT-ND4/MT-ND5	2.47063126482366
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	3/111	59/9376	4.29500687127806	NT5C3B/ENPP3/UPP1	2.77887299565594
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	4/111	104/9376	3.24878724878725	DGKH/AGPAT5/PLB1/PLD1	2.52407784000232
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	3/111	65/9376	3.8985446985447	LIPC/DGKH/AGPAT5	2.56662802957486
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	6/111	216/9376	2.34634634634635	HSPA1B/CD40LG/HSPA4/HSPA1A/TNFSF10/POU2F2	2.19109067531093
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	8/111	333/9376	2.029272515759	SPP1/PATJ/ATM/CCND2/VWF/IFNAR2/ATP6V1E2/MAML3	2.09324779905588
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	5/111	168/9376	2.51394251394251	IL7R/CISH/CCND2/IFNAR2/IL23A	2.1672339040878
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	3/111	71/9376	3.56909021697754	CISH/CCND2/TNFSF11	2.37834447227265
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	5/111	174/9376	2.42725484104794	HSPA1B/HSPH1/HSPA1A/DNAJB1/ERP29	2.07998139444077
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/111	38/9376	4.4457088667615	NMRK2/ENPP3	2.3295275969967
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	3/111	85/9376	2.981240063593	NT5C3B/ENPP3/UPP1	2.00835161596036
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	3/111	87/9376	2.91270580925753	MT-CO1/MT-CYB/MT-CO2	1.96176841294681
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	3/111	93/9376	2.72478930543447	CD3E/CD4/MAML3	1.82960679901162
NA	NA	hsa04518	Integrin signaling	4/111	154/9376	2.19398619398619	SPP1/ITGAD/CCND2/VWF	1.63520242433282
NA	NA	hsa03272	Virion - Hepatitis viruses	2/111	48/9376	3.51951951951952	CLDN4/SLC10A1	1.91543973779082
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	3/111	99/9376	2.55965055965056	DGKH/SLC44A1/PLD1	1.70751898142551
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	4/111	157/9376	2.15206289091639	PATJ/LEF1/ID1/CCND2	1.59334023208053
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	4/111	160/9376	2.11171171171171	CD40LG/CLDN4/CD4/CD2	1.55240615141451
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/111	51/9376	3.31248895954778	PLB1/PLD1	1.81244464567908
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	3/111	105/9376	2.41338481338481	CD40LG/ATM/TNFSF11	1.59410232549179
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/111	12/9376	7.03903903903904	SLAMF1	2.29114287952051
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	2/111	54/9376	3.12846179512846	BRCA1/EME1	1.71685099926723
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	7/111	362/9376	1.63336817480464	SPP1/BRCA1/IL7R/SGK1/CCND2/VWF/IFNAR2	1.34516686673294
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	3/111	109/9376	2.32482023307711	CD3E/CD4/IL23A	1.52273747297645
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	2/111	56/9376	3.01673101673102	HSPA1B/HSPA1A	1.65675561348553
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	3/111	112/9376	2.26254826254826	HSPA1B/CD40LG/HSPA1A	1.47123532003235
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	5/111	238/9376	1.7745476569006	VWF/IFNAR2/RPS15/RPS26/RPL23	1.32475467843471
Organismal Systems	Digestive system	hsa04978	Mineral absorption	2/111	61/9376	2.76945798257274	VDR/SLC34A2	1.51753304921434
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	2/111	62/9376	2.72478930543447	HSPA1B/HSPA1A	1.49137958673025
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	2/111	63/9376	2.68153868153868	TBXAS1/PLB1	1.46573936295606
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/111	16/9376	5.27927927927928	MIF	1.87506839449691
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	5/111	250/9376	1.68936936936937	HSPA1B/HSPA1A/ARAP2/PLD1/ACAP1	1.2092223634415
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	3/111	122/9376	2.07709348692955	CD3E/CD40LG/CD4	1.31066886626952
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	2/111	66/9376	2.55965055965056	IL23A/IL18R1	1.39171032240992
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/111	21/9376	4.02230802230802	ENPP3	1.51757754254186
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	2/111	75/9376	2.25249249249249	BRCA1/ATM	1.19197008673061
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	2/111	75/9376	2.25249249249249	ATM/CCND2	1.19197008673061
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	2/111	75/9376	2.25249249249249	GPX3/DUOX1	1.19197008673061
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	3/111	139/9376	1.82306047054249	HSPA1B/KRT19/HSPA1A	1.07003525842587
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	4/111	214/9376	1.5788498779153	CD3E/ATM/CD4/WEE1	0.937566550707108
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	2/111	82/9376	2.06020654801143	UGT2B7/UPP1	1.05540826306757
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	4/111	217/9376	1.55702246024827	VDR/UGT2B7/PAQR8/TNFSF11	0.908663242740722
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	3/111	148/9376	1.71219868517166	BRCA1/LEF1/TNFSF11	0.955878400319275
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	3/111	149/9376	1.70070741882822	DGKH/AGPAT5/PLD1	0.943678380015205
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/111	26/9376	3.24878724878725	PLB1	1.25676377576328
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/111	26/9376	3.24878724878725	PLB1	1.25676377576328
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	4/111	224/9376	1.50836550836551	CD3E/ATM/CD4/CCND2	0.842881449952269
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/111	27/9376	3.12846179512846	SCD5	1.2122426989969
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	2/111	88/9376	1.91973791973792	VWF/CD59	0.948787033439021
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/111	28/9376	3.01673101673102	ATP6V1E2	1.16974731565862
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	2/111	89/9376	1.8981678307521	SPP1/VWF	0.931835372809568
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	3/111	157/9376	1.6140471681873	MT-CO1/MT-CYB/MT-CO2	0.849247089878654
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	3/111	158/9376	1.60383167978105	ATM/CCND2/WEE1	0.837819572337782
Organismal Systems	Digestive system	hsa04976	Bile secretion	2/111	90/9376	1.87707707707708	UGT2B7/SLC10A1	0.915101129584572
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	2/111	90/9376	1.87707707707708	CD3E/CD4	0.915101129584572
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/111	30/9376	2.81561561561562	PLB1	1.09017461240865
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/111	31/9376	2.72478930543447	UGT2B7	1.05281402199005
Human Diseases	Immune disease	hsa05310	Asthma	1/111	32/9376	2.63963963963964	CD40LG	1.01690738021017
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	3/111	170/9376	1.4906200317965	CLDN4/PATJ/HSPA4	0.706575651222353
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	2/111	99/9376	1.70643370643371	DEFB1/KRT19	0.773409758609384
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	3/111	173/9376	1.46477112951101	DNAJB1/IFNAR2/TNFSF10	0.675339106934325
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	4/111	248/9376	1.36239465271723	LEF1/GAPDH/TNFSF10/VPS41	0.633059049467401
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/111	36/9376	2.34634634634635	UGT2B7	0.885847622962402
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/111	36/9376	2.34634634634635	ENPP3	0.885847622962402
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/111	36/9376	2.34634634634635	GALNT6	0.885847622962402
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/111	36/9376	2.34634634634635	DNA2	0.885847622962402
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/111	37/9376	2.28293158022888	RIMKLB	0.855812421800485
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/111	37/9376	2.28293158022888	MIF	0.855812421800485
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	1/111	37/9376	2.28293158022888	LEF1	0.855812421800485
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/111	38/9376	2.22285443338075	SGK1	0.826730655381106
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	2/111	109/9376	1.54988015538474	SPP1/IFNAR2	0.632027725230042
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/111	39/9376	2.16585816585817	CD40LG	0.798543830679435
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	3/111	187/9376	1.355109119815	GBP3/IFNAR2/CARD8	0.536874676081172
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	2/111	116/9376	1.45635290462877	CLDN4/TXK	0.541313347812288
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	2/111	116/9376	1.45635290462877	DLGAP1/PLD1	0.541313347812288
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	1/111	44/9376	1.91973791973792	MGAT4A	0.669310258177006
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	2/111	119/9376	1.41963812552048	CCL20/IL18R1	0.504240474747793
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/111	45/9376	1.87707707707708	DEFB1	0.645512027333076
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/111	46/9376	1.83627105366236	UGT2B7	0.622314004314508
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	3/111	200/9376	1.26702702702703	CLDN4/GAPDH/TNFSF10	0.417799515168609
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	3/111	201/9376	1.26072340997714	ATM/CCND2/PBX3	0.408977518608783
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	3/111	203/9376	1.2483024896818	SPP1/CCND2/VWF	0.391469392718378
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	2/111	125/9376	1.3514954954955	S1PR4/PLD1	0.433016899045135
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	3/111	205/9376	1.23612392880686	CD3E/CCND2/IFNAR2	0.374139016516286
Organismal Systems	Immune system	hsa04611	Platelet activation	2/111	126/9376	1.34076934076934	VWF/TBXAS1	0.421501705339066
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	1/111	49/9376	1.72384629527487	GALNT6	0.556029486940814
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	2/111	128/9376	1.31981981981982	ENPP3/PFAS	0.398759336151341
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/111	50/9376	1.68936936936937	CD40LG	0.534950619688002
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	1/111	50/9376	1.68936936936937	CD40LG	0.534950619688002
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	1/111	51/9376	1.65624447977389	ATP6V1E2	0.514340528507965
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	1/111	52/9376	1.62439362439362	LIPC	0.494178008683566
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	1/111	53/9376	1.59374468808431	VDR	0.474443221034809
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	2/111	133/9376	1.27020253336043	IFNAR2/TNFSF10	0.343505089637801
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	1/111	54/9376	1.56423089756423	MTAP	0.45511757952044
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	1/111	54/9376	1.56423089756423	CD40LG	0.45511757952044
NA	NA	hsa04382	Cornified envelope formation	3/111	217/9376	1.1677668451862	CLDN4/KRT19/KRT8	0.273675796669543
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	4/111	300/9376	1.12624624624625	HSPA1B/MECOM/HSPA1A/PTPN7	0.24325191804313
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	2/111	137/9376	1.23311632800684	ATM/TNFSF10	0.300846462607235
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	1/111	56/9376	1.50836550836551	MGAT4A	0.417625058919454
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	1/111	56/9376	1.50836550836551	CCND2	0.417625058919454
Genetic Information Processing	Translation	hsa03010	Ribosome	3/111	222/9376	1.14146579011444	RPS15/RPS26/RPL23	0.233478491394164
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/111	57/9376	1.48190295558717	SCD5	0.399426410631817
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	2/111	142/9376	1.18969673899251	IFNAR2/TNFSF11	0.24930645194422
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	1/111	59/9376	1.43166895709269	GPX3	0.364051807716731
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	1/111	59/9376	1.43166895709269	LEF1	0.364051807716731
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	2/111	144/9376	1.17317317317317	ID1/ZFHX3	0.229212542653214
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	2/111	144/9376	1.17317317317317	LEF1/SCD5	0.229212542653214
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	1/111	62/9376	1.36239465271723	MAML3	0.313353048804149
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/111	63/9376	1.34076934076934	MECOM	0.297036899559851
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	1/111	63/9376	1.34076934076934	LEF1	0.297036899559851
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	1/111	65/9376	1.2995148995149	SPP1	0.265217002434432
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/111	66/9376	1.27982527982528	UGT2B7	0.249694220281842
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	1/111	67/9376	1.26072340997714	GAPDH	0.234417661690784
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	2/111	156/9376	1.08292908292908	CLDN4/IFNAR2	0.114321553444675
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/111	68/9376	1.24218335983042	UGT2B7	0.219378965761163
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	1/111	68/9376	1.24218335983042	LEF1	0.219378965761163
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	2/111	157/9376	1.0760314454582	SGK1/VPS41	0.105153947676779
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	2/111	157/9376	1.0760314454582	ATM/CCND2	0.105153947676779
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	2/111	158/9376	1.06922111985403	SGK1/ATP6V1E2	0.0960446610781933
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/111	70/9376	1.20669240669241	UGT2B7	0.189983740401672
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	1/111	70/9376	1.20669240669241	CD40LG	0.189983740401672
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	3/111	250/9376	1.01362162162162	ATP6V1E2/VPS41/MEAK7	0.0238936776466746
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	1/111	71/9376	1.18969673899251	ATP6V1E2	0.175612435721223
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/111	73/9376	1.15710230778724	UGT2B7	0.147488072556206
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	1/111	73/9376	1.15710230778724	CD4	0.147488072556206
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/111	75/9376	1.12624624624625	GAPDH	0.120145829208197
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	2/111	168/9376	1.00557700557701	IFNAR2/TNFSF10	0.00798357629729142
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	1/111	76/9376	1.11142721669037	SCD5	0.10675322900437
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	1/111	77/9376	1.0969930969931	PLD1	0.0935389479668828
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	1/111	77/9376	1.0969930969931	MECOM	0.0935389479668828
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	1/111	78/9376	1.08292908292908	SEPTIN6	0.0804977624965013
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	1/111	78/9376	1.08292908292908	IL23A	0.0804977624965013
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/111	79/9376	1.06922111985403	UGT2B7	0.0676246712632959
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	1/111	79/9376	1.06922111985403	ATP6V1E2	0.0676246712632959
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	2/111	178/9376	0.94908391537605	LEF1/CCND2	-0.0750659031113204
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	2/111	180/9376	0.938538538538539	IFNAR2/POU2F2	-0.0911305664838805
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	2/111	181/9376	0.933353242745508	VDR/IL23A	-0.0990984495518643
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	1/111	86/9376	0.982191493819401	LEF1	-0.0181590563261721
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	1/111	87/9376	0.970901936419178	LEF1	-0.0298444547689921
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	2/111	193/9376	0.875320916771694	CXCL14/CCL20	-0.191559801498331
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	1/111	93/9376	0.908263101811489	LEF1	-0.0973118583916879
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	1/111	93/9376	0.908263101811489	PLD1	-0.0973118583916879
Organismal Systems	Digestive system	hsa04970	Salivary secretion	1/111	93/9376	0.908263101811489	PRH1	-0.0973118583916879
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	1/111	94/9376	0.898600728387962	CCL20	-0.108143991717276
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	2/111	196/9376	0.861923147637433	LEF1/IFNAR2	-0.213821803849084
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	1/111	98/9376	0.861923147637433	DGKH	-0.150394220720735
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	1/111	98/9376	0.861923147637433	PLD1	-0.150394220720735
NA	NA	hsa04517	IgSF CAM signaling	3/111	299/9376	0.847509717074934	SLAMF1/CABLES1/CD2	-0.29331279773766
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	1/111	99/9376	0.853216853216853	TTN	-0.160699464206742
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	1/111	101/9376	0.836321469984836	LEF1	-0.181017206940285
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	1/111	103/9376	0.82008221814047	COL15A1	-0.200958780426442
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	1/111	103/9376	0.82008221814047	CD3E	-0.200958780426442
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	1/111	105/9376	0.804461604461605	FKBP8	-0.220540229454003
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	1/111	105/9376	0.804461604461605	IL23A	-0.220540229454003
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	1/111	105/9376	0.804461604461605	TTN	-0.220540229454003
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	1/111	106/9376	0.796872344042155	LEF1	-0.230200646100331
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	1/111	108/9376	0.782115448782115	RANBP17	-0.249269831019581
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	1/111	110/9376	0.767895167895168	GAPDH	-0.26801480961771
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	1/111	110/9376	0.767895167895168	ID1	-0.26801480961771
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	3/111	323/9376	0.784536858840264	BRCA1/ATM/CCND2	-0.431322787970297
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	1/111	116/9376	0.728176452314383	GAPDH	-0.322429665987578
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	1/111	122/9376	0.692364495643184	SCD5	-0.374348450355054
Genetic Information Processing	Transcription	hsa03040	Spliceosome	2/111	243/9376	0.695213732250769	HSPA1B/HSPA1A	-0.526885466879135
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	2/111	253/9376	0.667734928604494	ATM/SEPTIN6	-0.586408866734467
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	1/111	138/9376	0.612090351220786	CD4	-0.502464706845965
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	1/111	140/9376	0.603346203346203	SPP1	-0.517556881107934
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	1/111	142/9376	0.594848369496257	BRCA1	-0.532465218098926
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	1/111	143/9376	0.590688590688591	CD40LG	-0.539852189666628
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	1/111	144/9376	0.586586586586587	FGF14	-0.547195260784841
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	1/111	150/9376	0.563123123123123	LEF1	-0.590367415270372
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	1/111	154/9376	0.548496548496548	UGT2B7	-0.618348471876565
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	1/111	155/9376	0.544957861086893	ATP6V1E2	-0.625248804402181
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	1/111	155/9376	0.544957861086893	LEF1	-0.625248804402181
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	1/111	163/9376	0.518211462996739	SLC10A1	-0.679163198845336
NA	NA	hsa04519	Cadherin signaling	3/111	404/9376	0.627241102488627	LEF1/KRT19/KRT8	-0.838298105032466
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	1/111	169/9376	0.499813422890346	VPS41	-0.718192274923016
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	1/111	170/9376	0.496873343932167	LEF1	-0.724587301005079
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	1/111	195/9376	0.433171633171633	VWF	-0.875484182569396
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	1/111	205/9376	0.412041309602285	CCND2	-0.931622166754399
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	1/111	212/9376	0.398436172021078	ID1	-0.969686881422482
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	1/111	226/9376	0.37375428525871	PLD1	-1.04306856058693
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	1/111	232/9376	0.364088226157192	ITGAD	-1.07348792945926
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	1/111	233/9376	0.3625256157445	TTN	-1.07850150262381
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	1/111	238/9376	0.35490953138012	PLD1	-1.10333639086523
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	1/111	254/9376	0.332553025466411	ORAI2	-1.18035599165838
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1/111	370/9376	0.228293158022888	S1PR4	-1.65772183239688