category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	16/150	238/9376	4.20212885154062	RPS10/PLCG2/RPL23/NRP1/RPL6/RPL13A/RPS11/RPL37A/RPS20/PRKCA/RPL31/CYBB/RPL38/RPS17/MMP1/MMP3	6.38008181475255
Organismal Systems	Immune system	hsa04611	Platelet activation	10/150	126/9376	4.96084656084656	ITPR2/TLN1/COL3A1/PLCG2/TBXAS1/PTGS1/PLCB2/ITGB3/PIK3CG/SNAP23	5.70725092796557
NA	NA	hsa04517	IgSF CAM signaling	15/150	299/9376	3.13578595317726	ITGA4/CADM1/PLCG2/NRP1/UNC5B/IL1RAPL2/PMP22/ARPC2/AFDN/PLXNA2/PRKCA/PAK1/ITGB3/ANK3/IL1RAP	4.78571349106979
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	8/150	100/9376	5.00053333333333	HLA-DRB1/ITGA4/IL7R/IL2RA/HLA-DPB1/CD1D/CSF1R/ITGB3	5.12816589431224
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	12/150	233/9376	3.21922746781116	ITGA9/ITGA4/TPM3/TLN1/COL3A1/DIAPH2/ITGB7/SYNE2/LBR/ITGB3/PDLIM2/ANK3	4.37381049488948
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	11/150	205/9376	3.3540162601626	MT-ATP8/MMP9/MT-ND4/MT-ND4L/MT-ND5/MT-ATP6/COL3A1/MT-CO2/PRKCA/CYBB/PLCB2	4.34512810229027
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	8/150	116/9376	4.31080459770115	MMP9/ITGA4/PLCG2/AFDN/RHOH/PRKCA/CYBB/CLDN1	4.57489987328718
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	12/150	248/9376	3.02451612903226	NAIP/TCF7L2/PFN1/PTPRC/HSP90AB1/NCKAP1L/ARPC2/PYCARD/RHOH/PAK1/PIK3CG/HSP90AA1	4.11987280824531
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	11/150	216/9376	3.18320987654321	MMP9/HSP90AB1/HSPA5/PYCARD/PRKCA/CYBB/MMP1/PLCB2/MMP3/POU2F2/HSP90AA1	4.13903566564992
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	7/150	106/9376	4.12779874213836	MMP9/FOLR3/TCF7L2/HSP90AB1/TGFA/MMP3/HSP90AA1	4.12929973971757
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	14/150	362/9376	2.41738489871087	ITGA9/ITGA4/IL7R/YWHAH/FLT1/HSP90AB1/IL2RA/ITGB7/CSF1R/PRKCA/TGFA/ITGB3/PIK3CG/HSP90AA1	3.50677460062969
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	6/150	86/9376	4.36093023255814	ITGA9/ITGA4/SLC8A1/TCF7L2/ITGB7/ITGB3	3.99232058950621
Genetic Information Processing	Translation	hsa03010	Ribosome	10/150	222/9376	2.81561561561562	RPS10/RPL23/RPL6/RPL13A/RPS11/RPL37A/RPS20/RPL31/RPL38/RPS17	3.49075593519687
NA	NA	hsa04518	Integrin signaling	8/150	154/9376	3.24709956709957	ITGA9/ITGA4/TLN1/FLT1/ITGB7/LIMS1/PARVG/ITGB3	3.58504540261928
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	9/150	193/9376	2.91481865284974	PLCG2/DOCK2/CX3CR1/PAK1/CCR6/CCL24/CXCL14/PLCB2/PIK3CG	3.42719293888062
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	8/150	160/9376	3.12533333333333	HLA-DRB1/ITGA9/ITGA4/CADM1/PTPRC/HLA-DPB1/ITGB7/CLDN1	3.45732617793692
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	5/150	69/9376	4.52946859903382	ALOX5AP/PLCG2/FCER1A/PRKCA/ALOX5	3.75191986026011
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	6/150	99/9376	3.78828282828283	ITGA9/ITGA4/SLC8A1/TPM3/ITGB7/ITGB3	3.55610999452538
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	9/150	203/9376	2.7712315270936	ITGA9/ITGA4/TLN1/FLT1/ITGB7/PRKCA/PAK1/PARVG/ITGB3	3.25306093689493
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	6/150	100/9376	3.7504	CX3CR1/IL2RA/CSF1R/CCR6/CCL24/CXCL14	3.52565678135825
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	6/150	105/9376	3.57180952380952	ITGA9/ITGA4/SLC8A1/TPM3/ITGB7/ITGB3	3.37905065148088
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	5/150	75/9376	4.16711111111111	ITPR2/HSPA5/GPX7/PRKCA/PLCB2	3.51118451083498
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	10/150	254/9376	2.46089238845144	ITPR2/SLC8A1/HRH2/CAMK1/FLT1/CYSLTR1/PLCG2/PRKCA/TGFA/PLCB2	3.00964029785811
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	7/150	142/9376	3.08131455399061	ITPR2/TYROBP/SPI1/PLCG2/LILRB1/CSF1R/ITGB3	3.18648222926258
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	6/150	109/9376	3.44073394495413	HLA-DRB1/HSP90AB1/IL2RA/HLA-DPB1/IL1RAP/HSP90AA1	3.26804969005337
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	4/150	50/9376	5.00053333333333	HLA-DRB1/ITGA4/HLA-DPB1/ITGB7	3.6164272465034
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	8/150	184/9376	2.71768115942029	SEMA6B/PLCG2/NRP1/UNC5B/PLXNA2/PRKCA/DPYSL2/PAK1	3.00034363634572
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	5/150	82/9376	3.81138211382114	HLA-DRB1/HSP90AB1/HSPA5/HLA-DPB1/HSP90AA1	3.26024330847452
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	8/150	187/9376	2.67408199643494	ITPR2/NAIP/HSP90AB1/PYCARD/CYBB/PLCB2/ANTXR1/HSP90AA1	2.94841047851064
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	9/150	232/9376	2.4248275862069	ITGA9/ITGA4/PFN1/DIAPH2/NCKAP1L/ARPC2/ITGB7/PAK1/ITGB3	2.80196522698816
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	7/150	157/9376	2.78692144373673	SIGLEC10/P2RY6/CX3CR1/MERTK/ALOX5/STAB1/ITGB3	2.87897518718074
NA	NA	hsa04981	Folate transport and metabolism	3/150	31/9376	6.04903225806452	FOLR3/SLCO2B1/ABCC4	3.59024331354174
Human Diseases	Immune disease	hsa05310	Asthma	3/150	32/9376	5.86	HLA-DRB1/FCER1A/HLA-DPB1	3.51131172041888
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	5/150	94/9376	3.32482269503546	MMP9/HSP90AB1/MMP1/MMP3/HSP90AA1	2.88840124773033
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	5/150	95/9376	3.28982456140351	HLA-DRB1/FLT1/HLA-DPB1/MMP1/MMP3	2.86016553006407
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	4/150	63/9376	3.96867724867725	HPGDS/TBXAS1/PTGS1/ALOX5	3.01448411720805
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	5/150	98/9376	3.1891156462585	PLCG2/PTPRC/ARPC2/PRKCA/PAK1	2.77766010620234
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	8/150	212/9376	2.35874213836478	TLN1/FLT1/PFN1/AFDN/CSF1R/PRKCA/PLCB2/ITGB3	2.55144950105976
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	5/150	99/9376	3.15690235690236	ITPR2/PLCG2/PRKCA/PLCB2/IL1RAP	2.75086226934859
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	5/150	101/9376	3.09438943894389	COL3A1/PLCG2/PRKCA/CYBB/PLCB2	2.69827189371029
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	6/150	138/9376	2.71768115942029	MT-ATP8/MT-ND4/MT-ND4L/MT-ND5/MT-ATP6/MT-CO2	2.59189652193459
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	6/150	139/9376	2.69812949640288	ITPR2/MMP9/HSP90AB1/TGFA/PLCB2/HSP90AA1	2.57180050119672
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	9/150	268/9376	2.09910447761194	MT-ATP8/ITPR2/MT-ND4/MT-ND4L/MT-ND5/MT-ATP6/HSPA5/MT-CO2/UBE2J1	2.32765926202229
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	4/150	73/9376	3.42502283105023	PLCG2/EML4/PRKCA/TGFA	2.65210243278918
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	5/150	110/9376	2.84121212121212	FLT1/PLCG2/PRKCA/CYBB/EGLN3	2.47672941756622
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	6/150	149/9376	2.51704697986577	ITPR2/MT-ND4/MT-ND4L/MT-ND5/PRKCA/PLCB2	2.3800520052932
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	9/150	275/9376	2.04567272727273	MT-ATP8/ITPR2/MT-ND4/MT-ND4L/MT-ND5/MT-ATP6/HSPA5/MT-CO2/CYBB	2.24409952302751
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	4/150	76/9376	3.28982456140351	ITPR2/HRH2/PRKCA/PLCB2	2.55559525968728
Human Diseases	Cancer: specific types	hsa05214	Glioma	4/150	76/9376	3.28982456140351	CAMK1/PLCG2/PRKCA/TGFA	2.55559525968728
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	4/150	78/9376	3.20547008547009	HLA-DRB1/ITGA4/HLA-DPB1/CYBB	2.49389545928896
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	5/150	115/9376	2.71768115942029	ITPR2/PTGS1/PRKCA/ALOX5/PLCB2	2.36312705698325
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	7/150	201/9376	2.17684908789386	MMP9/FLT1/SPI1/ITGB7/CSF1R/MAF/MMP3	2.15050427347852
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	13/150	480/9376	1.69288888888889	MT-ATP8/ITPR2/MT-ND4/MT-ND4L/MT-ND5/MT-ATP6/HSPA5/GPX7/MT-CO2/PRKCA/CYBB/PLCB2/UBE2J1	1.98706178554127
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	7/150	204/9376	2.14483660130719	ITPR2/MMP9/PLCG2/PRKCA/PAK1/ITGB3/ANK3	2.10790536389313
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	4/150	86/9376	2.90728682170543	PLCG2/PRKCA/TGFA/PAK1	2.26559313092099
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	8/150	253/9376	1.9764953886693	ITPR2/NAIP/TLN1/PFN1/PLCG2/ARPC2/PYCARD/PLCB2	2.0076414911356
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	3/150	53/9376	3.53811320754717	SLC8A1/PRKCA/PLCB2	2.36262951100492
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	4/150	89/9376	2.80928838951311	ITGA9/ITGA4/ITGB7/ITGB3	2.18670208681123
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	3/150	54/9376	3.47259259259259	LACC1/DNMT1/AHCYL2	2.32337566928839
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/150	24/9376	5.20888888888889	HS3ST3B1/HS3ST1	2.63236056006869
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	5/150	130/9376	2.40410256410256	MMP9/COL3A1/PRKCA/MMP1/PLCB2	2.05550296053274
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	3/150	55/9376	3.40945454545455	ACER3/SGPL1/NEU4	2.28503770703211
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	4/150	93/9376	2.68845878136201	HLA-DRB1/IL2RA/HLA-DPB1/MAF	2.08647076914874
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	5/150	133/9376	2.34987468671679	TYROBP/PLCG2/LAT2/PRKCA/PAK1	1.99911298438681
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	7/150	224/9376	1.95333333333333	HLA-DRB1/TLN1/VAC14/SPI1/NRP1/IL2RA/HLA-DPB1	1.84134566811863
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	3/150	59/9376	3.17830508474576	GSTM4/HPGDS/GPX7	2.14008590120499
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	10/150	368/9376	1.69855072463768	MT-ATP8/MT-ND4/MT-ND4L/MT-ND5/MT-ATP6/PFN1/HSPA5/GPX7/MT-CO2/HNRNPA3	1.74313976670711
Organismal Systems	Nervous system	hsa04730	Long-term depression	3/150	60/9376	3.12533333333333	ITPR2/PRKCA/PLCB2	2.10577750258849
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	7/150	227/9376	1.92751835535977	MT-ATP8/MT-ND4/MT-ND4L/MT-ND5/GSTM4/MT-ATP6/MT-CO2	1.80373681851818
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	4/150	98/9376	2.5512925170068	ITPR2/PLCG2/PRKCA/PLCB2	1.96835801932375
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	4/150	98/9376	2.5512925170068	ITPR2/CAMK1/PRKCA/PLCB2	1.96835801932375
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	5/150	142/9376	2.20093896713615	MMP9/GSTM4/HSP90AB1/ITGB3/HSP90AA1	1.83863158496203
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/150	30/9376	4.16711111111111	FOLR3/ABCC4	2.21531547629552
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	4/150	103/9376	2.42744336569579	COL3A1/CD1D/PRKCA/PLCB2	1.85734213686631
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	3/150	65/9376	2.88492307692308	ITPR2/PRKCA/PLCB2	1.94436004939116
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	7/150	238/9376	1.83843137254902	FLT1/PLCG2/AFDN/CSF1R/PRKCA/TGFA/PAK1	1.67053263654408
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	4/150	105/9376	2.38120634920635	ITPR2/PLCG2/PYCARD/PAK1	1.81474023286217
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	3/150	66/9376	2.84121212121212	HLA-DRB1/HLA-DPB1/MAF	1.91392755554569
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	5/150	149/9376	2.09753914988814	PLCG2/FCER1A/PRKCA/PLCB2/PIK3CG	1.72189806199028
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	3/150	67/9376	2.79880597014925	ITPR2/PRKCA/PLCB2	1.88406008598116
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	10/150	388/9376	1.61099656357388	MT-ATP8/ITPR2/MT-ND4/MT-ND4L/MT-ND5/MT-ATP6/MT-CO2/CYBB/PLCB2/PSENEN	1.56728378761606
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	3/150	68/9376	2.75764705882353	TCF7L2/SPI1/CSF1R	1.85473763053992
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	5/150	154/9376	2.02943722943723	SLC8A1/TPM3/PRKCA/PLCB2/PIK3CG	1.64237457953083
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	5/150	154/9376	2.02943722943723	ITPR2/CAMK1/PRKCA/PLCB2/PIK3CG	1.64237457953083
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	3/150	70/9376	2.67885714285714	TGFA/PAK1/EGLN3	1.79765265815246
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	6/150	200/9376	1.8752	NAIP/NCKAP1L/ARPC2/PYCARD/PAK1/CLDN1	1.5952183875586
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	5/150	155/9376	2.01634408602151	HLA-DRB1/HLA-DPB1/CORO1A/CYBB/ITGB3	1.62682989713843
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	4/150	112/9376	2.23238095238095	HLA-DRB1/HLA-DPB1/ALOX5/PIK3CG	1.67293573470319
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	8/150	298/9376	1.67803131991051	IL7R/CX3CR1/IL2RA/CSF1R/CCR6/CCL24/CXCL14/IL1RAP	1.5166568846652
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	4/150	115/9376	2.17414492753623	ITPR2/PRKCA/PLCB2/PIK3CG	1.61534847830371
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	4/150	116/9376	2.15540229885057	ITPR2/HOMER1/PRKCA/PLCB2	1.59654539391344
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	2/150	37/9376	3.37873873873874	PRKCA/PLCB2	1.84851067195643
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	2/150	37/9376	3.37873873873874	TPM3/TCF7L2	1.84851067195643
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	8/150	308/9376	1.62354978354978	MT-ATP8/MT-ND4/MT-ND4L/MT-ND5/MT-ATP6/GPX7/MT-CO2/PLCB2	1.41878071923942
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	3/150	76/9376	2.46736842105263	SLC27A4/MMP1/PLIN5	1.63767995341897
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/150	38/9376	3.28982456140351	NMRK2/PNP	1.8033981322434
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	2/150	38/9376	3.28982456140351	IL7R/PTPRC	1.8033981322434
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/150	39/9376	3.20547008547009	HLA-DRB1/HLA-DPB1	1.75976363211735
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	3/150	78/9376	2.40410256410256	PLCG2/PLCB2/PIK3CG	1.58772727504259
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	4/150	122/9376	2.04939890710383	PLCG2/PRKCA/PLCB2/ITGB3	1.48757995590656
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	4/150	122/9376	2.04939890710383	ITPR2/PLCG2/PRKCA/PLCB2	1.48757995590656
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	3/150	80/9376	2.344	PLCG2/PRKCA/TGFA	1.53929106079783
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	5/150	170/9376	1.83843137254902	GSTM4/TCF7L2/PLCG2/PRKCA/TGFA	1.40663376624033
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	2/150	41/9376	3.04910569105691	MMP9/MMP1	1.67657763808186
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	4/150	125/9376	2.00021333333333	FCER1A/PRKCA/SGPL1/PLCB2	1.43541621615165
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	2/150	42/9376	2.97650793650794	SLC40A1/CYBB	1.63686872946699
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	5/150	174/9376	1.79616858237548	ERP29/HSP90AB1/HSPA5/UBE2J1/HSP90AA1	1.35164638790068
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	2/150	44/9376	2.84121212121212	HLA-DRB1/HLA-DPB1	1.5608721835674
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	2/150	45/9376	2.77807407407407	HLA-DRB1/HLA-DPB1	1.52446182839039
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	3/150	87/9376	2.15540229885057	SLC8A1/TPM3/MT-CO2	1.38048888657082
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	3/150	87/9376	2.15540229885057	TCF7L2/TGFA/MSH3	1.38048888657082
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	3/150	89/9376	2.10696629213483	ITPR2/PRKCA/PLCB2	1.33787709857152
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	6/150	235/9376	1.59591489361702	MT-ATP8/MT-ND4/MT-ND4L/MT-ND5/MT-ATP6/MT-CO2	1.17963013637761
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	3/150	91/9376	2.06065934065934	PLCG2/LILRB1/CARD11	1.29637368169851
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	4/150	138/9376	1.81178743961353	ITGA4/ARPC2/PYCARD/SKAP2	1.22494738313052
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	4/150	140/9376	1.78590476190476	ITPR2/SLC8A1/PLCB2/PIK3CG	1.19458351846295
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	3/150	93/9376	2.01634408602151	ITPR2/PRKCA/PLCB2	1.25592182070947
Organismal Systems	Digestive system	hsa04970	Salivary secretion	3/150	93/9376	2.01634408602151	ITPR2/PRKCA/PLCB2	1.25592182070947
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/150	13/9376	4.80820512820513	PRKDC	1.75189890259173
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	2/150	51/9376	2.45124183006536	PLCG2/PRKCA	1.32502782463766
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	5/150	195/9376	1.60273504273504	PLCG2/PRKCA/CYBB/PLCB2/ITGB3	1.0844843682009
NA	NA	hsa04082	Neuroactive ligand signaling	5/150	199/9376	1.57051926298157	P2RY13/HRH2/P2RY6/PRKCA/PLCB2	1.03722034644882
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/150	54/9376	2.31506172839506	HLA-DRB1/HLA-DPB1	1.23569990160076
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	3/150	101/9376	1.85663366336634	TCF7L2/PRKCA/PLCB2	1.10362977108642
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	3/150	102/9376	1.83843137254902	ITPR2/PRKCA/PLCB2	1.08557192508496
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	2/150	56/9376	2.23238095238095	NAIP/PYCARD	1.17938493828697
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	2/150	60/9376	2.08355555555556	PLCG2/PRKCA	1.07358543523855
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/150	18/9376	3.47259259259259	NEU4	1.33881891212657
Organismal Systems	Digestive system	hsa04978	Mineral absorption	2/150	61/9376	2.04939890710383	SLC8A1/SLC40A1	1.04842806534286
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	5/150	214/9376	1.46043613707165	ITPR2/SAMHD1/PLCG2/PRKCA/PAK1	0.868771743506387
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	4/150	166/9376	1.50618473895582	ITPR2/SLC8A1/PLCB2/PIK3CG	0.838991998412467
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/150	20/9376	3.12533333333333	LBR	1.21316951184337
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	2/150	65/9376	1.92328205128205	ITPR2/PLCB2	0.9523957538698
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	3/150	115/9376	1.63060869565217	ITPR2/PRKCA/PLCB2	0.86756989962416
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	4/150	168/9376	1.48825396825397	HSP90AB1/PYCARD/CYBB/HSP90AA1	0.814221019714287
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	4/150	170/9376	1.47074509803922	CD1D/ARPC2/AFDN/CLDN1	0.789767620671135
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	4/150	173/9376	1.4452408477842	HLA-DRB1/HLA-DPB1/PYCARD/PRKCA	0.753664196420791
Organismal Systems	Endocrine system	hsa04924	Renin secretion	2/150	69/9376	1.81178743961353	ITPR2/PLCB2	0.862951838650572
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/150	70/9376	1.78590476190476	GSTM4/HPGDS	0.841515188057302
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	2/150	70/9376	1.78590476190476	HLA-DRB1/HLA-DPB1	0.841515188057302
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	3/150	122/9376	1.53704918032787	PTPRC/CARD11/PAK1	0.761296386515814
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/150	23/9376	2.71768115942029	MSH3	1.05161202973172
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	2/150	71/9376	1.76075117370892	PLCG2/PAK1	0.820423627696162
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	4/150	178/9376	1.40464419475655	TCF7L2/PRKCA/TBL1XR1/PLCB2	0.69496215511551
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	4/150	180/9376	1.38903703703704	HLA-DRB1/HLA-DPB1/ITGB3/POU2F2	0.67197367986626
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/150	73/9376	1.71251141552511	GSTM4/HPGDS	0.779231120758498
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	3/150	128/9376	1.465	PGM2/LACC1/PNP	0.675396133040904
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	2/150	75/9376	1.66684444444444	GSTM4/MSH3	0.739290098239799
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	6/150	300/9376	1.25013333333333	FLT1/CSF1R/PRKCA/TGFA/PAK1/IL1RAP	0.561447945541507
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	3/150	133/9376	1.40992481203008	ITPR2/PRKCA/PLCB2	0.607083029569823
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/150	79/9376	1.58244725738397	GSTM4/HPGDS	0.662862235824197
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	3/150	134/9376	1.39940298507463	ITPR2/PRKCA/PLCB2	0.59375224685593
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/150	29/9376	2.15540229885057	PAK1	0.794548930659412
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	4/150	196/9376	1.2756462585034	ITPR2/TCF7L2/PLCG2/PIK3CG	0.497259787003803
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	2/150	83/9376	1.50618473895582	SAMHD1/PYCARD	0.590601665863393
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/150	31/9376	2.01634408602151	PGM2	0.72269741459231
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/150	31/9376	2.01634408602151	HSPA5	0.72269741459231
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	2/150	85/9376	1.47074509803922	LACC1/PNP	0.555889641883671
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	2/150	86/9376	1.45364341085271	PRKCA/PLCB2	0.538865672335785
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	3/150	143/9376	1.31132867132867	HLA-DRB1/HLA-DPB1/SNRPD3	0.478343923873098
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/150	32/9376	1.95333333333333	PGM2	0.688775824444307
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	3/150	144/9376	1.30222222222222	ITPR2/PRKCA/PLCB2	0.465998249544555
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/150	33/9376	1.89414141414141	SNAP23	0.656061494243635
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	2/150	89/9376	1.40464419475655	SLC12A5/PRKCA	0.489052110331799
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	2/150	90/9376	1.38903703703704	EML4/BATF3	0.472848925591702
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	2/150	93/9376	1.344229390681	TCF7L2/AFDN	0.425372872270199
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/150	36/9376	1.7362962962963	PGM2	0.5643583704052
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/150	37/9376	1.68936936936937	PGM2	0.535706849788312
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	3/150	155/9376	1.2098064516129	ITPR2/TCF7L2/PLCB2	0.335830564462177
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/150	38/9376	1.64491228070175	PGM2	0.507913847236188
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/150	38/9376	1.64491228070175	PRKCA	0.507913847236188
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	4/150	217/9376	1.15219662058372	GSTM4/HSP90AB1/PRKCA/HSP90AA1	0.28922470671358
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	2/150	97/9376	1.28879725085911	PRKCA/PLCB2	0.364546453134831
NA	NA	hsa04081	Hormone signaling	4/150	219/9376	1.14167427701674	SLC40A1/HAMP/PLCB2/ITGB3	0.270496093848072
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/150	39/9376	1.60273504273504	AHCYL2	0.480927497042768
NA	NA	hsa04519	Cadherin signaling	7/150	404/9376	1.08303630363036	YWHAH/TCF7L2/NCKAP1L/ARPC2/LIMA1/AFDN/PSENEN	0.217539737909789
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	2/150	99/9376	1.26276094276094	HLA-DRB1/HLA-DPB1	0.335119093818239
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	4/150	226/9376	1.10631268436578	AFDN/PAK1/ABCC4/FFAR2	0.206278183933103
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	2/150	103/9376	1.2137216828479	SLC8A1/COL3A1	0.278087591182215
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	4/150	227/9376	1.10143906020558	ITPR2/PRKCA/PLCB2/ITGB3	0.197267651547141
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/150	43/9376	1.45364341085271	SLC27A4	0.380156783673964
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	2/150	105/9376	1.19060317460317	PLCG2/CARD11	0.25042981424346
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	1/150	44/9376	1.42060606060606	MAN2A1	0.356565271690513
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	2/150	107/9376	1.16834890965732	ITPR2/PLCB2	0.223311093551504
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/150	45/9376	1.38903703703704	ABCC4	0.333547472200729
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	2/150	110/9376	1.13648484848485	HSP90AB1/HSP90AA1	0.183594293889373
NA	NA	hsa03272	Virion - Hepatitis viruses	1/150	48/9376	1.30222222222222	CLDN1	0.267656187251396
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/150	48/9376	1.30222222222222	PLCB2	0.267656187251396
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	3/150	181/9376	1.03602209944751	HLA-DRB1/HLA-DPB1/CORO1A	0.0623960337200867
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/150	51/9376	1.22562091503268	PLD4	0.205998741247037
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/150	52/9376	1.20205128205128	ALOX5	0.186288777390585
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	1/150	52/9376	1.20205128205128	APOC2	0.186288777390585
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	2/150	119/9376	1.05053221288515	MMP9/MMP3	0.0707344870568773
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	2/150	120/9376	1.04177777777778	PLCG2/SH2B2	0.0587284891245282
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	5/150	323/9376	0.967595459236326	MMP9/PLCG2/PRKCA/DNMT1/ITGB3	-0.075567562623806
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	1/150	56/9376	1.11619047619048	MAN2A1	0.111193943176979
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1/150	59/9376	1.05943502824859	PTGS1	0.0583922182816591
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	1/150	59/9376	1.05943502824859	TCF7L2	0.0583922182816591
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	5/150	333/9376	0.938538538538539	ITGA9/ITGA4/TCF7L2/ITGB7/ITGB3	-0.145610695696013
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	2/150	133/9376	0.939949874686717	IL7R/HOMER1	-0.0889319478386706
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	1/150	62/9376	1.00817204301075	PSENEN	0.00823157452159767
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	1/150	63/9376	0.992169312169312	TCF7L2	-0.00795151581497817
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	3/150	205/9376	0.914731707317073	HLA-DRB1/PLCG2/HLA-DPB1	-0.157391289533958
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	2/150	138/9376	0.905893719806763	ITPR2/YWHAH	-0.142001755673545
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	1/150	67/9376	0.932935323383084	PGM2	-0.0702431960366911
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/150	68/9376	0.91921568627451	DHRS4L2	-0.0852467541033519
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/150	69/9376	0.905893719806763	PRKCA	-0.100037501885939
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	1/150	73/9376	0.856255707762557	SAMHD1	-0.157204535256841
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	5/150	370/9376	0.844684684684685	P2RY13/HRH2/CYSLTR1/P2RY6/UTS2	-0.388663463079303
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	1/150	77/9376	0.811774891774892	TGFA	-0.211460539964913
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	2/150	156/9376	0.801367521367521	YWHAH/CLDN1	-0.318986015072616
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	1/150	78/9376	0.801367521367521	ARPC2	-0.224609093450145
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	1/150	78/9376	0.801367521367521	PYCARD	-0.224609093450145
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	2/150	157/9376	0.796263269639066	YWHAH/TCF7L2	-0.328247776913958
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	2/150	158/9376	0.791223628691983	YWHAH/PRKDC	-0.337455164530791
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1/150	82/9376	0.762276422764228	GSTM4	-0.275678179120287
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	2/150	163/9376	0.766952965235174	MMP9/PRKCA	-0.382702580540557
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	1/150	83/9376	0.753092369477912	MBD5	-0.288084658975574
Genetic Information Processing	Transcription	hsa03040	Spliceosome	3/150	243/9376	0.771687242798354	HNRNPA3/SNRPD3/RBMX	-0.459781115248703
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/150	86/9376	0.726821705426357	PLCB2	-0.32449805695682
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	2/150	168/9376	0.744126984126984	IL7R/IL2RA	-0.426698401748839
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	1/150	88/9376	0.71030303030303	PROCR	-0.348135833768514
Organismal Systems	Digestive system	hsa04976	Bile secretion	1/150	90/9376	0.694518518518519	ABCC4	-0.371292644543065
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	3/150	250/9376	0.75008	FOLR3/IL2RA/ARPC2	-0.510687616489055
Human Diseases	Substance dependence	hsa05032	Morphine addiction	1/150	91/9376	0.686886446886447	PRKCA	-0.382697963501827
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	1/150	99/9376	0.631380471380471	MMP9	-0.470128631358545
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	1/150	99/9376	0.631380471380471	PRKCA	-0.470128631358545
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	1/150	103/9376	0.606860841423948	PLCB2	-0.511539681659835
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	1/150	104/9376	0.601025641025641	PLD4	-0.521674353359579
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	1/150	109/9376	0.573455657492355	SLC27A4	-0.571126610996648
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	1/150	110/9376	0.568242424242424	HAMP	-0.580784080669578
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	2/150	205/9376	0.609821138211382	YWHAH/VAC14	-0.720206213511986
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	1/150	117/9376	0.534245014245014	TFPT	-0.646387492015262
NA	NA	hsa04382	Cornified envelope formation	2/150	217/9376	0.576098310291859	SLC27A4/CLDN1	-0.805555612279768
Human Diseases	Infectious disease: viral	hsa05162	Measles	1/150	136/9376	0.459607843137255	IL2RA	-0.809407172060598
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	1/150	137/9376	0.45625304136253	ITPR2	-0.817465030380975
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	1/150	138/9376	0.452946859903382	SH2B2	-0.825476325075579
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	1/150	142/9376	0.44018779342723	UBE2J1	-0.857069703639063
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	1/150	144/9376	0.434074074074074	TCF7L2	-0.872604565323628
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	1/150	148/9376	0.422342342342342	TCF7L2	-0.903175487682873
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	1/150	150/9376	0.416711111111111	TCF7L2	-0.91822085113856
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	1/150	157/9376	0.398131634819533	ITPR2	-0.969692369732897
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	1/150	157/9376	0.398131634819533	MT-CO2	-0.969692369732897
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	1/150	158/9376	0.395611814345992	PRKCA	-0.976901329171189
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	1/150	183/9376	0.341566484517304	RMRP	-1.14692068800694
Cellular Processes	Cell motility	hsa04814	Motor proteins	1/150	194/9376	0.322199312714777	TPM3	-1.21635058463089
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/150	449/9376	0.139213066072754	SLC8A1	-2.3833652987536