ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003779 actin binding 21/255 443/18639 0.0474040632054176 3.46495817288541 8.52151800906373e-07 0.000539412089973734 GO:0023023 MHC protein complex binding 5/255 37/18639 0.135135135135135 9.87758346581876 0.000140447881630119 0.0322359064342739 GO:0003735 structural constituent of ribosome 10/255 175/18639 0.0571428571428571 4.17680672268907 0.000152776807745374 0.0322359064342739 GO:0042169 SH2 domain binding 5/255 41/18639 0.121951219512195 8.91391678622669 0.000230942283065033 0.0365466162950415 GO:0140375 immune receptor activity 9/255 156/18639 0.0576923076923077 4.21696832579186 0.000303191378407912 0.0383840285064417 GO:0023026 MHC class II protein complex binding 4/255 27/18639 0.148148148148148 10.8287581699346 0.000468709431112702 0.0413928947853572 GO:0030246 carbohydrate binding 12/255 280/18639 0.0428571428571429 3.13260504201681 0.000500251294351985 0.0413928947853572 GO:0044325 transmembrane transporter binding 8/255 136/18639 0.0588235294117647 4.29965397923875 0.000574094032701162 0.0413928947853572 GO:0051015 actin filament binding 10/255 209/18639 0.0478468899521531 3.49732620320856 0.000629001488524939 0.0413928947853572 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 3/255 13/18639 0.230769230769231 16.8678733031674 0.000653916189342136 0.0413928947853572 GO:0019955 cytokine binding 8/255 144/18639 0.0555555555555556 4.06078431372549 0.000836010740539818 0.0481086180692459 GO:0019956 chemokine binding 4/255 33/18639 0.121212121212121 8.85989304812834 0.00102479788494581 0.0526074185687324 GO:0004601 peroxidase activity 5/255 57/18639 0.087719298245614 6.41176470588235 0.00108040512068487 0.0526074185687324 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 3/255 16/18639 0.1875 13.7051470588235 0.00124210548666719 0.053320917869734 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 5/255 59/18639 0.0847457627118644 6.19441674975075 0.00126352885947237 0.053320917869734 GO:0005178 integrin binding 8/255 161/18639 0.0496894409937888 3.63200584581659 0.00171087831170784 0.0676866232069415 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 4/255 39/18639 0.102564102564103 7.49683257918552 0.00193194664683035 0.0707568834254843 GO:0004896 cytokine receptor activity 6/255 96/18639 0.0625 4.56838235294118 0.00205308756476644 0.0707568834254843 GO:0140662 ATP-dependent protein folding chaperone 4/255 40/18639 0.1 7.30941176470588 0.00212382430503033 0.0707568834254843 GO:0001614 purinergic nucleotide receptor activity 3/255 20/18639 0.15 10.9641176470588 0.00242848643539821 0.0732015196955747 GO:0016502 nucleotide receptor activity 3/255 20/18639 0.15 10.9641176470588 0.00242848643539821 0.0732015196955747 GO:0019838 growth factor binding 7/255 136/18639 0.0514705882352941 3.76219723183391 0.00270275909579943 0.0777657503473201 GO:0005518 collagen binding 5/255 72/18639 0.0694444444444444 5.07598039215686 0.00305918119719765 0.084193986862005 GO:0033691 sialic acid binding 3/255 22/18639 0.136363636363636 9.96737967914438 0.00321513731045453 0.0847992465632383 GO:0008237 metallopeptidase activity 8/255 184/18639 0.0434782608695652 3.17800511508951 0.00389954054182184 0.0938790688332882 GO:0004222 metalloendopeptidase activity 6/255 110/18639 0.0545454545454545 3.98695187165775 0.00405108462831026 0.0938790688332882 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 3/255 24/18639 0.125 9.13676470588235 0.00414141949468311 0.0938790688332882 GO:0038187 pattern recognition receptor activity 4/255 48/18639 0.0833333333333333 6.09117647058823 0.00415262863717546 0.0938790688332882 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 3/255 25/18639 0.12 8.77129411764706 0.00465908895119578 0.101696665727825 GO:0005021 vascular endothelial growth factor receptor activity 4/255 51/18639 0.0784313725490196 5.73287197231834 0.00516599293841619 0.109002451000582 GO:0004364 glutathione transferase activity 3/255 27/18639 0.111111111111111 8.12156862745098 0.00580733616139706 0.118582057747237 GO:0051082 unfolded protein binding 6/255 121/18639 0.0495867768595041 3.62450170150705 0.00642434801089461 0.121553212159042 GO:0050698 proteoglycan sulfotransferase activity 3/255 28/18639 0.107142857142857 7.83151260504202 0.00643929739136496 0.121553212159042 GO:0016209 antioxidant activity 5/255 86/18639 0.0581395348837209 4.24965800273598 0.00652892450775266 0.121553212159042 GO:0003785 actin monomer binding 3/255 29/18639 0.103448275862069 7.56146044624747 0.00711065579848452 0.126338629173438 GO:0016651 oxidoreductase activity, acting on NAD(P)H 5/255 88/18639 0.0568181818181818 4.15307486631016 0.00718513530844195 0.126338629173438 GO:0071723 lipopeptide binding 2/255 10/18639 0.2 14.6188235294118 0.00780370642526425 0.133506653167359 GO:0004714 transmembrane receptor protein tyrosine kinase activity 4/255 60/18639 0.0666666666666667 4.87294117647059 0.00916409548074039 0.145934459335196 GO:0003953 NAD+ nucleosidase activity 2/255 11/18639 0.181818181818182 13.2898395721925 0.00945231095220071 0.145934459335196 GO:0042608 T cell receptor binding 2/255 11/18639 0.181818181818182 13.2898395721925 0.00945231095220071 0.145934459335196 GO:1990948 ubiquitin ligase inhibitor activity 2/255 11/18639 0.181818181818182 13.2898395721925 0.00945231095220071 0.145934459335196 GO:0015026 coreceptor activity 4/255 61/18639 0.0655737704918033 4.7930568948891 0.00970412871105166 0.146255082716564 GO:0015132 prostaglandin transmembrane transporter activity 2/255 12/18639 0.166666666666667 12.1823529411765 0.0112411459855216 0.165480125786865 GO:0017154 semaphorin receptor activity 2/255 13/18639 0.153846153846154 11.2452488687783 0.0131660968575543 0.185203095796264 GO:0071714 icosanoid transmembrane transporter activity 2/255 13/18639 0.153846153846154 11.2452488687783 0.0131660968575543 0.185203095796264 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 4/255 68/18639 0.0588235294117647 4.29965397923875 0.0140664228172826 0.193566209637824 GO:0032036 myosin heavy chain binding 2/255 14/18639 0.142857142857143 10.4420168067227 0.0152231344700052 0.204502495256433 GO:0097110 scaffold protein binding 4/255 70/18639 0.0571428571428571 4.17680672268907 0.0155072982184973 0.204502495256433 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 2/255 15/18639 0.133333333333333 9.74588235294117 0.0174083137378349 0.211912742231721 GO:0016846 carbon-sulfur lyase activity 2/255 15/18639 0.133333333333333 9.74588235294117 0.0174083137378349 0.211912742231721 GO:0034483 heparan sulfate sulfotransferase activity 2/255 15/18639 0.133333333333333 9.74588235294117 0.0174083137378349 0.211912742231721 GO:0055105 ubiquitin-protein transferase inhibitor activity 2/255 15/18639 0.133333333333333 9.74588235294117 0.0174083137378349 0.211912742231721 GO:0008137 NADH dehydrogenase (ubiquinone) activity 3/255 41/18639 0.0731707317073171 5.34835007173601 0.0184032977970851 0.2197978774633 GO:0044183 protein folding chaperone 4/255 75/18639 0.0533333333333333 3.89835294117647 0.01950521336705 0.226933631156716 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 2/255 16/18639 0.125 9.13676470588235 0.0197177720594303 0.226933631156716 GO:0048156 tau protein binding 3/255 43/18639 0.0697674418604651 5.09958960328317 0.0208864738001169 0.234141974975217 GO:0009055 electron transfer activity 5/255 116/18639 0.0431034482758621 3.15060851926978 0.0216818047084482 0.234141974975217 GO:0019199 transmembrane receptor protein kinase activity 4/255 78/18639 0.0512820512820513 3.74841628959276 0.0221824135143056 0.234141974975217 GO:0003954 NADH dehydrogenase activity 3/255 44/18639 0.0681818181818182 4.98368983957219 0.0221935521303523 0.234141974975217 GO:0019205 nucleobase-containing compound kinase activity 3/255 44/18639 0.0681818181818182 4.98368983957219 0.0221935521303523 0.234141974975217 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 2/255 18/18639 0.111111111111111 8.12156862745098 0.0246944788763298 0.244906940006923 GO:0001618 virus receptor activity 4/255 81/18639 0.0493827160493827 3.60958605664488 0.0250733729742478 0.244906940006923 GO:0140272 exogenous protein binding 4/255 82/18639 0.0487804878048781 3.56556671449067 0.0260851035846218 0.244906940006923 GO:0030506 ankyrin binding 2/255 19/18639 0.105263157894737 7.69411764705882 0.0273544011768251 0.244906940006923 GO:0032266 phosphatidylinositol-3-phosphate binding 3/255 48/18639 0.0625 4.56838235294118 0.0278584140599494 0.244906940006923 GO:0005004 GPI-linked ephrin receptor activity 3/255 49/18639 0.0612244897959184 4.47515006002401 0.0293834871979623 0.244906940006923 GO:0005008 hepatocyte growth factor receptor activity 3/255 49/18639 0.0612244897959184 4.47515006002401 0.0293834871979623 0.244906940006923 GO:0005009 insulin receptor activity 3/255 49/18639 0.0612244897959184 4.47515006002401 0.0293834871979623 0.244906940006923 GO:0005011 macrophage colony-stimulating factor receptor activity 3/255 49/18639 0.0612244897959184 4.47515006002401 0.0293834871979623 0.244906940006923 GO:0005018 platelet-derived growth factor alpha-receptor activity 3/255 49/18639 0.0612244897959184 4.47515006002401 0.0293834871979623 0.244906940006923 GO:0005020 stem cell factor receptor activity 3/255 49/18639 0.0612244897959184 4.47515006002401 0.0293834871979623 0.244906940006923 GO:0008288 boss receptor activity 3/255 49/18639 0.0612244897959184 4.47515006002401 0.0293834871979623 0.244906940006923 GO:0036332 placental growth factor receptor activity 3/255 49/18639 0.0612244897959184 4.47515006002401 0.0293834871979623 0.244906940006923 GO:0038062 protein tyrosine kinase collagen receptor activity 3/255 49/18639 0.0612244897959184 4.47515006002401 0.0293834871979623 0.244906940006923 GO:0060175 brain-derived neurotrophic factor receptor activity 3/255 49/18639 0.0612244897959184 4.47515006002401 0.0293834871979623 0.244906940006923 GO:0051020 GTPase binding 9/255 315/18639 0.0285714285714286 2.08840336134454 0.0298543136549348 0.244906940006923 GO:0005006 epidermal growth factor receptor activity 3/255 50/18639 0.06 4.38564705882353 0.030951903950322 0.244906940006923 GO:0005007 fibroblast growth factor receptor activity 3/255 50/18639 0.06 4.38564705882353 0.030951903950322 0.244906940006923 GO:0005017 platelet-derived growth factor receptor activity 3/255 50/18639 0.06 4.38564705882353 0.030951903950322 0.244906940006923 GO:0005019 platelet-derived growth factor beta-receptor activity 3/255 50/18639 0.06 4.38564705882353 0.030951903950322 0.244906940006923 GO:0005010 insulin-like growth factor receptor activity 3/255 51/18639 0.0588235294117647 4.29965397923875 0.0325635233885661 0.247700205539384 GO:0005030 neurotrophin receptor activity 3/255 51/18639 0.0588235294117647 4.29965397923875 0.0325635233885661 0.247700205539384 GO:0015125 bile acid transmembrane transporter activity 2/255 21/18639 0.0952380952380952 6.96134453781513 0.0329996448826864 0.247700205539384 GO:0070182 DNA polymerase binding 2/255 21/18639 0.0952380952380952 6.96134453781513 0.0329996448826864 0.247700205539384 GO:0016798 hydrolase activity, acting on glycosyl bonds 5/255 130/18639 0.0384615384615385 2.81131221719457 0.0332614809965998 0.247700205539384 GO:0005003 ephrin receptor activity 3/255 53/18639 0.0566037735849057 4.13740288568258 0.035915696945047 0.249690417042492 GO:0005005 transmembrane-ephrin receptor activity 3/255 53/18639 0.0566037735849057 4.13740288568258 0.035915696945047 0.249690417042492 GO:0008146 sulfotransferase activity 3/255 53/18639 0.0566037735849057 4.13740288568258 0.035915696945047 0.249690417042492 GO:0016860 intramolecular oxidoreductase activity 3/255 53/18639 0.0566037735849057 4.13740288568258 0.035915696945047 0.249690417042492 GO:0038064 collagen receptor activity 3/255 53/18639 0.0566037735849057 4.13740288568258 0.035915696945047 0.249690417042492 GO:0061133 endopeptidase activator activity 2/255 22/18639 0.0909090909090909 6.64491978609626 0.0359780956399096 0.249690417042492 GO:0072341 modified amino acid binding 4/255 91/18639 0.043956043956044 3.21292824822237 0.0362899184327161 0.249690417042492 GO:0051213 dioxygenase activity 4/255 93/18639 0.043010752688172 3.1438330170778 0.0388289611256427 0.260236118827448 GO:0004602 glutathione peroxidase activity 2/255 23/18639 0.0869565217391304 6.35601023017903 0.039055973599696 0.260236118827448 GO:0016493 C-C chemokine receptor activity 2/255 23/18639 0.0869565217391304 6.35601023017903 0.039055973599696 0.260236118827448 GO:0045296 cadherin binding 9/255 334/18639 0.0269461077844311 1.96960197252554 0.0409225418403037 0.269274472349415 GO:0170055 lipid transmembrane transporter activity 3/255 56/18639 0.0535714285714286 3.91575630252101 0.0412632287802421 0.269274472349415 GO:0015078 proton transmembrane transporter activity 6/255 185/18639 0.0324324324324324 2.3706200317965 0.0421164943681005 0.270016213887196 GO:0019957 C-C chemokine binding 2/255 24/18639 0.0833333333333333 6.09117647058823 0.042230023972879 0.270016213887196 GO:0031406 carboxylic acid binding 6/255 187/18639 0.0320855614973262 2.3452658068575 0.0439851153108175 0.278425779917475 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 3/255 58/18639 0.0517241379310345 3.78073022312373 0.0450382677619393 0.282114799230896 GO:0005537 D-mannose binding 2/255 25/18639 0.08 5.84752941176471 0.0454970618008514 0.282114799230896 GO:0043177 organic acid binding 6/255 189/18639 0.0317460317460317 2.32044817927171 0.045904935735833 0.282114799230896 GO:0001637 G protein-coupled chemoattractant receptor activity 2/255 26/18639 0.0769230769230769 5.62262443438914 0.0488539706664567 0.289014611512777 GO:0004435 phosphatidylinositol phospholipase C activity 2/255 26/18639 0.0769230769230769 5.62262443438914 0.0488539706664567 0.289014611512777 GO:0004950 chemokine receptor activity 2/255 26/18639 0.0769230769230769 5.62262443438914 0.0488539706664567 0.289014611512777 GO:0030507 spectrin binding 2/255 26/18639 0.0769230769230769 5.62262443438914 0.0488539706664567 0.289014611512777 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 3/255 61/18639 0.0491803278688525 3.59479267116683 0.0510101310185772 0.298976045692216 GO:0015252 proton channel activity 2/255 27/18639 0.0740740740740741 5.41437908496732 0.0522977014268615 0.303710504616544 GO:0005507 copper ion binding 3/255 63/18639 0.0476190476190476 3.48067226890756 0.0551937817258585 0.317615125749713 GO:0097718 disordered domain specific binding 2/255 28/18639 0.0714285714285714 5.22100840336134 0.0558252709680535 0.318354923628629 GO:0140996 histone H3 kinase activity 9/255 357/18639 0.0252100840336134 1.84270884824518 0.0576755287161892 0.325969729262034 GO:0004629 phospholipase C activity 2/255 29/18639 0.0689655172413793 5.04097363083164 0.0594337609806142 0.33293425398875 GO:0035173 histone kinase activity 9/255 360/18639 0.025 1.82735294117647 0.0601447645012001 0.333961718677716 GO:0001968 fibronectin binding 2/255 30/18639 0.0666666666666667 4.87294117647059 0.0631203167564196 0.347436178320119 GO:0016500 protein-hormone receptor activity 3/255 67/18639 0.0447761194029851 3.27287093942054 0.0640337911226483 0.349425773971003 GO:0005200 structural constituent of cytoskeleton 4/255 112/18639 0.0357142857142857 2.61050420168067 0.0678714381566159 0.367201883360153 GO:0008028 monocarboxylic acid transmembrane transporter activity 3/255 70/18639 0.0428571428571429 3.13260504201681 0.0710648434713246 0.37801719258276 GO:0016782 transferase activity, transferring sulphur-containing groups 3/255 70/18639 0.0428571428571429 3.13260504201681 0.0710648434713246 0.37801719258276 GO:0030695 GTPase regulator activity 11/255 489/18639 0.0224948875255624 1.64424395525081 0.0738874399300051 0.387660460775145 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 2/255 33/18639 0.0606060606060606 4.42994652406417 0.0746207609060312 0.387660460775145 GO:0060589 nucleoside-triphosphatase regulator activity 11/255 490/18639 0.0224489795918367 1.64088835534214 0.0747149703231718 0.387660460775145 GO:0042379 chemokine receptor binding 3/255 72/18639 0.0416666666666667 3.04558823529412 0.0759367692612745 0.390796544247047 GO:1990782 protein tyrosine kinase binding 4/255 117/18639 0.0341880341880342 2.49894419306184 0.076963497390497 0.392886240711166 GO:0015399 primary active transmembrane transporter activity 5/255 166/18639 0.0301204819277108 2.20163004961021 0.0781510449962101 0.395756891860808 GO:0022853 active monoatomic ion transmembrane transporter activity 4/255 118/18639 0.0338983050847458 2.4777666999003 0.078851866611793 0.396136758454484 GO:0048029 monosaccharide binding 3/255 74/18639 0.0405405405405405 2.96327503974563 0.0809521178493286 0.403485752745079 GO:0017022 myosin binding 3/255 76/18639 0.0394736842105263 2.88529411764706 0.0861071308617303 0.422293235069208 GO:0008528 G protein-coupled peptide receptor activity 4/255 122/18639 0.0327868852459016 2.39652844744455 0.086633894775084 0.422293235069208 GO:0055106 ubiquitin-protein transferase regulator activity 2/255 36/18639 0.0555555555555556 4.06078431372549 0.0867268887187946 0.422293235069208 GO:0003823 antigen binding 5/255 174/18639 0.028735632183908 2.10040567951318 0.0911092692455922 0.440245552919541 GO:0031267 small GTPase binding 7/255 283/18639 0.0247349823321555 1.80798170858449 0.0947195788492324 0.454184252631871 GO:0035091 phosphatidylinositol binding 7/255 284/18639 0.0246478873239437 1.80161557580779 0.0960479613230968 0.454184252631871 GO:0048306 calcium-dependent protein binding 3/255 80/18639 0.0375 2.74102941176471 0.0968205971586001 0.454184252631871 GO:0042826 histone deacetylase binding 4/255 127/18639 0.031496062992126 2.30217693376563 0.0968639401347592 0.454184252631871 GO:0001653 peptide receptor activity 4/255 128/18639 0.03125 2.28419117647059 0.0989752703136764 0.46067166256292 GO:0016853 isomerase activity 5/255 180/18639 0.0277777777777778 2.03039215686274 0.101510864119923 0.469024649546797 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 4/255 130/18639 0.0307692307692308 2.24904977375566 0.103261813110965 0.472220835085621 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 2/255 40/18639 0.05 3.65470588235294 0.103694622554347 0.472220835085621 GO:0017080 sodium channel regulator activity 2/255 41/18639 0.0487804878048781 3.56556671449067 0.108068536644462 0.484791276190716 GO:0048487 beta-tubulin binding 2/255 42/18639 0.0476190476190476 3.48067226890756 0.112490810025082 0.484791276190716 GO:0141003 histone H2AX kinase activity 8/255 354/18639 0.0225988700564972 1.6518444666002 0.114014098331815 0.484791276190716 GO:0033218 amide binding 6/255 247/18639 0.0242914979757085 1.77556561085973 0.124075543449988 0.484791276190716 GO:0035403 histone H3T6 kinase activity 6/255 247/18639 0.0242914979757085 1.77556561085973 0.124075543449988 0.484791276190716 GO:0019210 kinase inhibitor activity 3/255 90/18639 0.0333333333333333 2.43647058823529 0.12576806615629 0.484791276190716 GO:0004713 protein tyrosine kinase activity 4/255 140/18639 0.0285714285714286 2.08840336134454 0.125921374301709 0.484791276190716 GO:0008009 chemokine activity 2/255 45/18639 0.0444444444444444 3.24862745098039 0.12602674419031 0.484791276190716 GO:0042605 peptide antigen binding 2/255 45/18639 0.0444444444444444 3.24862745098039 0.12602674419031 0.484791276190716 GO:0004090 carbonyl reductase (NADPH) activity 1/255 10/18639 0.1 7.30941176470588 0.128716516394945 0.484791276190716 GO:0005381 iron ion transmembrane transporter activity 1/255 10/18639 0.1 7.30941176470588 0.128716516394945 0.484791276190716 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 1/255 10/18639 0.1 7.30941176470588 0.128716516394945 0.484791276190716 GO:0008519 ammonium channel activity 1/255 10/18639 0.1 7.30941176470588 0.128716516394945 0.484791276190716 GO:0015924 mannosyl-oligosaccharide mannosidase activity 1/255 10/18639 0.1 7.30941176470588 0.128716516394945 0.484791276190716 GO:0016175 superoxide-generating NAD(P)H oxidase activity 1/255 10/18639 0.1 7.30941176470588 0.128716516394945 0.484791276190716 GO:0016303 1-phosphatidylinositol-3-kinase activity 1/255 10/18639 0.1 7.30941176470588 0.128716516394945 0.484791276190716 GO:0016427 tRNA (cytidine) methyltransferase activity 1/255 10/18639 0.1 7.30941176470588 0.128716516394945 0.484791276190716 GO:0016868 intramolecular phosphotransferase activity 1/255 10/18639 0.1 7.30941176470588 0.128716516394945 0.484791276190716 GO:0031957 very long-chain fatty acid-CoA ligase activity 1/255 10/18639 0.1 7.30941176470588 0.128716516394945 0.484791276190716 GO:0032395 MHC class II receptor activity 1/255 10/18639 0.1 7.30941176470588 0.128716516394945 0.484791276190716 GO:0035256 G protein-coupled glutamate receptor binding 1/255 10/18639 0.1 7.30941176470588 0.128716516394945 0.484791276190716 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 1/255 10/18639 0.1 7.30941176470588 0.128716516394945 0.484791276190716 GO:0043295 glutathione binding 1/255 10/18639 0.1 7.30941176470588 0.128716516394945 0.484791276190716 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 1/255 10/18639 0.1 7.30941176470588 0.128716516394945 0.484791276190716 GO:0070097 delta-catenin binding 1/255 10/18639 0.1 7.30941176470588 0.128716516394945 0.484791276190716 GO:0140940 histone H2A methyltransferase activity 1/255 10/18639 0.1 7.30941176470588 0.128716516394945 0.484791276190716 GO:1990259 histone H2AQ104 methyltransferase activity 1/255 10/18639 0.1 7.30941176470588 0.128716516394945 0.484791276190716 GO:0004180 carboxypeptidase activity 2/255 46/18639 0.0434782608695652 3.17800511508951 0.130621653178019 0.484791276190716 GO:0001784 phosphotyrosine residue binding 2/255 47/18639 0.0425531914893617 3.11038798498123 0.135254757653885 0.484791276190716 GO:0140938 histone H3 methyltransferase activity 2/255 47/18639 0.0425531914893617 3.11038798498123 0.135254757653885 0.484791276190716 GO:0005114 type II transforming growth factor beta receptor binding 1/255 11/18639 0.0909090909090909 6.64491978609626 0.14064293693922 0.484791276190716 GO:0016176 superoxide-generating NADPH oxidase activator activity 1/255 11/18639 0.0909090909090909 6.64491978609626 0.14064293693922 0.484791276190716 GO:0019206 nucleoside kinase activity 1/255 11/18639 0.0909090909090909 6.64491978609626 0.14064293693922 0.484791276190716 GO:0034511 U3 snoRNA binding 1/255 11/18639 0.0909090909090909 6.64491978609626 0.14064293693922 0.484791276190716 GO:0034713 type I transforming growth factor beta receptor binding 1/255 11/18639 0.0909090909090909 6.64491978609626 0.14064293693922 0.484791276190716 GO:0047676 arachidonate-CoA ligase activity 1/255 11/18639 0.0909090909090909 6.64491978609626 0.14064293693922 0.484791276190716 GO:0048407 platelet-derived growth factor binding 1/255 11/18639 0.0909090909090909 6.64491978609626 0.14064293693922 0.484791276190716 GO:0050786 RAGE receptor binding 1/255 11/18639 0.0909090909090909 6.64491978609626 0.14064293693922 0.484791276190716 GO:0140031 phosphorylation-dependent protein binding 1/255 11/18639 0.0909090909090909 6.64491978609626 0.14064293693922 0.484791276190716 GO:1900750 oligopeptide binding 1/255 11/18639 0.0909090909090909 6.64491978609626 0.14064293693922 0.484791276190716 GO:0016763 pentosyltransferase activity 2/255 49/18639 0.0408163265306122 2.98343337334934 0.144628022480041 0.484791276190716 GO:0060590 ATPase regulator activity 2/255 49/18639 0.0408163265306122 2.98343337334934 0.144628022480041 0.484791276190716 GO:0005543 phospholipid binding 10/255 497/18639 0.0201207243460765 1.47070659249615 0.14544567561798 0.484791276190716 GO:0004725 protein tyrosine phosphatase activity 3/255 98/18639 0.0306122448979592 2.237575030012 0.150874037040534 0.484791276190716 GO:0004000 adenosine deaminase activity 1/255 12/18639 0.0833333333333333 6.09117647058823 0.152406736116829 0.484791276190716 GO:0005095 GTPase inhibitor activity 1/255 12/18639 0.0833333333333333 6.09117647058823 0.152406736116829 0.484791276190716 GO:0015368 calcium:monoatomic cation antiporter activity 1/255 12/18639 0.0833333333333333 6.09117647058823 0.152406736116829 0.484791276190716 GO:0016273 arginine N-methyltransferase activity 1/255 12/18639 0.0833333333333333 6.09117647058823 0.152406736116829 0.484791276190716 GO:0016274 protein-arginine N-methyltransferase activity 1/255 12/18639 0.0833333333333333 6.09117647058823 0.152406736116829 0.484791276190716 GO:0017166 vinculin binding 1/255 12/18639 0.0833333333333333 6.09117647058823 0.152406736116829 0.484791276190716 GO:0031543 peptidyl-proline dioxygenase activity 1/255 12/18639 0.0833333333333333 6.09117647058823 0.152406736116829 0.484791276190716 GO:0035259 nuclear glucocorticoid receptor binding 1/255 12/18639 0.0833333333333333 6.09117647058823 0.152406736116829 0.484791276190716 GO:0035497 cAMP response element binding 1/255 12/18639 0.0833333333333333 6.09117647058823 0.152406736116829 0.484791276190716 GO:0036009 protein-glutamine N-methyltransferase activity 1/255 12/18639 0.0833333333333333 6.09117647058823 0.152406736116829 0.484791276190716 GO:0042301 phosphate ion binding 1/255 12/18639 0.0833333333333333 6.09117647058823 0.152406736116829 0.484791276190716 GO:0045295 gamma-catenin binding 1/255 12/18639 0.0833333333333333 6.09117647058823 0.152406736116829 0.484791276190716 GO:0070679 inositol 1,4,5 trisphosphate binding 1/255 12/18639 0.0833333333333333 6.09117647058823 0.152406736116829 0.484791276190716 GO:0097371 MDM2/MDM4 family protein binding 1/255 12/18639 0.0833333333333333 6.09117647058823 0.152406736116829 0.484791276190716 GO:0097677 STAT family protein binding 1/255 12/18639 0.0833333333333333 6.09117647058823 0.152406736116829 0.484791276190716 GO:1990247 N6-methyladenosine-containing RNA reader activity 1/255 12/18639 0.0833333333333333 6.09117647058823 0.152406736116829 0.484791276190716 GO:0005080 protein kinase C binding 2/255 52/18639 0.0384615384615385 2.81131221719457 0.158928464652776 0.486495808914857 GO:0005172 vascular endothelial growth factor receptor binding 1/255 13/18639 0.0769230769230769 5.62262443438914 0.164010122721768 0.486495808914857 GO:0005542 folic acid binding 1/255 13/18639 0.0769230769230769 5.62262443438914 0.164010122721768 0.486495808914857 GO:0008253 5'-nucleotidase activity 1/255 13/18639 0.0769230769230769 5.62262443438914 0.164010122721768 0.486495808914857 GO:0031994 insulin-like growth factor I binding 1/255 13/18639 0.0769230769230769 5.62262443438914 0.164010122721768 0.486495808914857 GO:0032396 inhibitory MHC class I receptor activity 1/255 13/18639 0.0769230769230769 5.62262443438914 0.164010122721768 0.486495808914857 GO:0035325 Toll-like receptor binding 1/255 13/18639 0.0769230769230769 5.62262443438914 0.164010122721768 0.486495808914857 GO:0035673 oligopeptide transmembrane transporter activity 1/255 13/18639 0.0769230769230769 5.62262443438914 0.164010122721768 0.486495808914857 GO:0070700 BMP receptor binding 1/255 13/18639 0.0769230769230769 5.62262443438914 0.164010122721768 0.486495808914857 GO:0071837 HMG box domain binding 1/255 13/18639 0.0769230769230769 5.62262443438914 0.164010122721768 0.486495808914857 GO:0097157 pre-mRNA intronic binding 1/255 13/18639 0.0769230769230769 5.62262443438914 0.164010122721768 0.486495808914857 GO:0005096 GTPase activator activity 6/255 271/18639 0.022140221402214 1.61831994790536 0.168331888511646 0.486495808914857 GO:0005161 platelet-derived growth factor receptor binding 1/255 14/18639 0.0714285714285714 5.22100840336134 0.175455275664212 0.486495808914857 GO:0005344 oxygen carrier activity 1/255 14/18639 0.0714285714285714 5.22100840336134 0.175455275664212 0.486495808914857 GO:0008559 ABC-type xenobiotic transporter activity 1/255 14/18639 0.0714285714285714 5.22100840336134 0.175455275664212 0.486495808914857 GO:0019763 immunoglobulin receptor activity 1/255 14/18639 0.0714285714285714 5.22100840336134 0.175455275664212 0.486495808914857 GO:0019992 diacylglycerol binding 1/255 14/18639 0.0714285714285714 5.22100840336134 0.175455275664212 0.486495808914857 GO:0030983 mismatched DNA binding 1/255 14/18639 0.0714285714285714 5.22100840336134 0.175455275664212 0.486495808914857 GO:0044548 S100 protein binding 1/255 14/18639 0.0714285714285714 5.22100840336134 0.175455275664212 0.486495808914857 GO:0005126 cytokine receptor binding 6/255 275/18639 0.0218181818181818 1.5947807486631 0.176287836341111 0.486495808914857 GO:0016504 peptidase activator activity 2/255 57/18639 0.0350877192982456 2.56470588235294 0.18329120149842 0.486495808914857 GO:0000774 adenyl-nucleotide exchange factor activity 1/255 15/18639 0.0666666666666667 4.87294117647059 0.186744344373238 0.486495808914857 GO:0004129 cytochrome-c oxidase activity 1/255 15/18639 0.0666666666666667 4.87294117647059 0.186744344373238 0.486495808914857 GO:0004467 long-chain fatty acid-CoA ligase activity 1/255 15/18639 0.0666666666666667 4.87294117647059 0.186744344373238 0.486495808914857 GO:0004559 alpha-mannosidase activity 1/255 15/18639 0.0666666666666667 4.87294117647059 0.186744344373238 0.486495808914857 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 1/255 15/18639 0.0666666666666667 4.87294117647059 0.186744344373238 0.486495808914857 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 1/255 15/18639 0.0666666666666667 4.87294117647059 0.186744344373238 0.486495808914857 GO:0004953 icosanoid receptor activity 1/255 15/18639 0.0666666666666667 4.87294117647059 0.186744344373238 0.486495808914857 GO:0005041 low-density lipoprotein particle receptor activity 1/255 15/18639 0.0666666666666667 4.87294117647059 0.186744344373238 0.486495808914857 GO:0005523 tropomyosin binding 1/255 15/18639 0.0666666666666667 4.87294117647059 0.186744344373238 0.486495808914857 GO:0008252 nucleotidase activity 1/255 15/18639 0.0666666666666667 4.87294117647059 0.186744344373238 0.486495808914857 GO:0031005 filamin binding 1/255 15/18639 0.0666666666666667 4.87294117647059 0.186744344373238 0.486495808914857 GO:0050700 CARD domain binding 1/255 15/18639 0.0666666666666667 4.87294117647059 0.186744344373238 0.486495808914857 GO:0051371 muscle alpha-actinin binding 1/255 15/18639 0.0666666666666667 4.87294117647059 0.186744344373238 0.486495808914857 GO:0120283 protein serine/threonine kinase binding 1/255 15/18639 0.0666666666666667 4.87294117647059 0.186744344373238 0.486495808914857 GO:0001786 phosphatidylserine binding 2/255 59/18639 0.0338983050847458 2.4777666999003 0.193184625489904 0.486495808914857 GO:0045309 protein phosphorylated amino acid binding 2/255 59/18639 0.0338983050847458 2.4777666999003 0.193184625489904 0.486495808914857 GO:0070063 RNA polymerase binding 2/255 59/18639 0.0338983050847458 2.4777666999003 0.193184625489904 0.486495808914857 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 4/255 167/18639 0.0239520958083832 1.75075730891159 0.195881753975968 0.486495808914857 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 1/255 16/18639 0.0625 4.56838235294118 0.197879449194159 0.486495808914857 GO:0005159 insulin-like growth factor receptor binding 1/255 16/18639 0.0625 4.56838235294118 0.197879449194159 0.486495808914857 GO:0005324 long-chain fatty acid transmembrane transporter activity 1/255 16/18639 0.0625 4.56838235294118 0.197879449194159 0.486495808914857 GO:0005521 lamin binding 1/255 16/18639 0.0625 4.56838235294118 0.197879449194159 0.486495808914857 GO:0015562 efflux transmembrane transporter activity 1/255 16/18639 0.0625 4.56838235294118 0.197879449194159 0.486495808914857 GO:0015923 mannosidase activity 1/255 16/18639 0.0625 4.56838235294118 0.197879449194159 0.486495808914857 GO:0016675 oxidoreductase activity, acting on a heme group of donors 1/255 16/18639 0.0625 4.56838235294118 0.197879449194159 0.486495808914857 GO:0055102 lipase inhibitor activity 1/255 16/18639 0.0625 4.56838235294118 0.197879449194159 0.486495808914857 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 2/255 60/18639 0.0333333333333333 2.43647058823529 0.19815724401431 0.486495808914857 GO:0019207 kinase regulator activity 6/255 287/18639 0.0209059233449477 1.528100020496 0.201036924390787 0.486495808914857 GO:0019905 syntaxin binding 2/255 61/18639 0.0327868852459016 2.39652844744455 0.203145281742979 0.486495808914857 GO:0005085 guanyl-nucleotide exchange factor activity 5/255 230/18639 0.0217391304347826 1.58900255754476 0.207954390281322 0.486495808914857 GO:0035401 histone H3Y41 kinase activity 3/255 115/18639 0.0260869565217391 1.90680306905371 0.208654056656579 0.486495808914857 GO:0140801 histone H2AXY142 kinase activity 3/255 115/18639 0.0260869565217391 1.90680306905371 0.208654056656579 0.486495808914857 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 1/255 17/18639 0.0588235294117647 4.29965397923875 0.208862681780503 0.486495808914857 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 1/255 17/18639 0.0588235294117647 4.29965397923875 0.208862681780503 0.486495808914857 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 1/255 17/18639 0.0588235294117647 4.29965397923875 0.208862681780503 0.486495808914857 GO:0015278 intracellularly gated calcium channel activity 1/255 17/18639 0.0588235294117647 4.29965397923875 0.208862681780503 0.486495808914857 GO:0015347 sodium-independent organic anion transmembrane transporter activity 1/255 17/18639 0.0588235294117647 4.29965397923875 0.208862681780503 0.486495808914857 GO:0016018 cyclosporin A binding 1/255 17/18639 0.0588235294117647 4.29965397923875 0.208862681780503 0.486495808914857 GO:0016805 dipeptidase activity 1/255 17/18639 0.0588235294117647 4.29965397923875 0.208862681780503 0.486495808914857 GO:0019198 transmembrane receptor protein phosphatase activity 1/255 17/18639 0.0588235294117647 4.29965397923875 0.208862681780503 0.486495808914857 GO:0030169 low-density lipoprotein particle binding 1/255 17/18639 0.0588235294117647 4.29965397923875 0.208862681780503 0.486495808914857 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 1/255 17/18639 0.0588235294117647 4.29965397923875 0.208862681780503 0.486495808914857 GO:0036041 long-chain fatty acid binding 1/255 17/18639 0.0588235294117647 4.29965397923875 0.208862681780503 0.486495808914857 GO:0048038 quinone binding 1/255 17/18639 0.0588235294117647 4.29965397923875 0.208862681780503 0.486495808914857 GO:0051787 misfolded protein binding 1/255 17/18639 0.0588235294117647 4.29965397923875 0.208862681780503 0.486495808914857 GO:0070402 NADPH binding 1/255 17/18639 0.0588235294117647 4.29965397923875 0.208862681780503 0.486495808914857 GO:1990226 histone methyltransferase binding 1/255 17/18639 0.0588235294117647 4.29965397923875 0.208862681780503 0.486495808914857 GO:0004857 enzyme inhibitor activity 8/255 416/18639 0.0192307692307692 1.40565610859729 0.211595143537303 0.486495808914857 GO:0004536 DNA nuclease activity 2/255 64/18639 0.03125 2.28419117647059 0.21818862013128 0.486495808914857 GO:0008409 5'-3' exonuclease activity 1/255 18/18639 0.0555555555555556 4.06078431372549 0.219696105480749 0.486495808914857 GO:0017075 syntaxin-1 binding 1/255 18/18639 0.0555555555555556 4.06078431372549 0.219696105480749 0.486495808914857 GO:0030228 lipoprotein particle receptor activity 1/255 18/18639 0.0555555555555556 4.06078431372549 0.219696105480749 0.486495808914857 GO:0032393 MHC class I receptor activity 1/255 18/18639 0.0555555555555556 4.06078431372549 0.219696105480749 0.486495808914857 GO:0070064 proline-rich region binding 1/255 18/18639 0.0555555555555556 4.06078431372549 0.219696105480749 0.486495808914857 GO:0004252 serine-type endopeptidase activity 4/255 176/18639 0.0227272727272727 1.66122994652406 0.221451781811307 0.486495808914857 GO:0019843 rRNA binding 2/255 65/18639 0.0307692307692308 2.24904977375566 0.223225210326573 0.486495808914857 GO:0106310 protein serine kinase activity 7/255 361/18639 0.0193905817174515 1.41733746130031 0.226332943594582 0.486495808914857 GO:0008235 metalloexopeptidase activity 2/255 66/18639 0.0303030303030303 2.21497326203209 0.228270820944001 0.486495808914857 GO:0042578 phosphoric ester hydrolase activity 7/255 363/18639 0.0192837465564738 1.40952843947496 0.230337751038344 0.486495808914857 GO:0003756 protein disulfide isomerase activity 1/255 19/18639 0.0526315789473684 3.84705882352941 0.230381755719856 0.486495808914857 GO:0005520 insulin-like growth factor binding 1/255 19/18639 0.0526315789473684 3.84705882352941 0.230381755719856 0.486495808914857 GO:0015245 fatty acid transmembrane transporter activity 1/255 19/18639 0.0526315789473684 3.84705882352941 0.230381755719856 0.486495808914857 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 1/255 19/18639 0.0526315789473684 3.84705882352941 0.230381755719856 0.486495808914857 GO:0034987 immunoglobulin receptor binding 1/255 19/18639 0.0526315789473684 3.84705882352941 0.230381755719856 0.486495808914857 GO:0042800 histone H3K4 methyltransferase activity 1/255 19/18639 0.0526315789473684 3.84705882352941 0.230381755719856 0.486495808914857 GO:0043395 heparan sulfate proteoglycan binding 1/255 19/18639 0.0526315789473684 3.84705882352941 0.230381755719856 0.486495808914857 GO:0050145 nucleoside monophosphate kinase activity 1/255 19/18639 0.0526315789473684 3.84705882352941 0.230381755719856 0.486495808914857 GO:0042054 histone methyltransferase activity 2/255 67/18639 0.0298507462686567 2.1819139596137 0.233324268015427 0.486495808914857 GO:0050840 extracellular matrix binding 2/255 67/18639 0.0298507462686567 2.1819139596137 0.233324268015427 0.486495808914857 GO:0031625 ubiquitin protein ligase binding 6/255 302/18639 0.0198675496688742 1.45220101285547 0.233627492388679 0.486495808914857 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 4/255 181/18639 0.0220994475138122 1.61533961650959 0.236023611609619 0.486495808914857 GO:1990841 promoter-specific chromatin binding 2/255 68/18639 0.0294117647058824 2.14982698961938 0.238384398035527 0.486495808914857 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 5/255 243/18639 0.0205761316872428 1.5039941902687 0.240186519606812 0.486495808914857 GO:0016004 phospholipase activator activity 1/255 20/18639 0.05 3.65470588235294 0.240921640375679 0.486495808914857 GO:0016505 peptidase activator activity involved in apoptotic process 1/255 20/18639 0.05 3.65470588235294 0.240921640375679 0.486495808914857 GO:0031418 L-ascorbic acid binding 1/255 20/18639 0.05 3.65470588235294 0.240921640375679 0.486495808914857 GO:0042288 MHC class I protein binding 1/255 20/18639 0.05 3.65470588235294 0.240921640375679 0.486495808914857 GO:0140664 ATP-dependent DNA damage sensor activity 1/255 20/18639 0.05 3.65470588235294 0.240921640375679 0.486495808914857 GO:0140939 histone H4 methyltransferase activity 1/255 20/18639 0.05 3.65470588235294 0.240921640375679 0.486495808914857 GO:0016279 protein-lysine N-methyltransferase activity 2/255 69/18639 0.0289855072463768 2.11867007672634 0.243450087355464 0.486495808914857 GO:0004676 3-phosphoinositide-dependent protein kinase activity 5/255 245/18639 0.0204081632653061 1.49171668667467 0.245264491314213 0.486495808914857 GO:0004711 ribosomal protein S6 kinase activity 5/255 245/18639 0.0204081632653061 1.49171668667467 0.245264491314213 0.486495808914857 GO:0035175 histone H3S10 kinase activity 5/255 245/18639 0.0204081632653061 1.49171668667467 0.245264491314213 0.486495808914857 GO:0035979 histone H2AXS139 kinase activity 5/255 245/18639 0.0204081632653061 1.49171668667467 0.245264491314213 0.486495808914857 GO:0044022 histone H3S28 kinase activity 5/255 245/18639 0.0204081632653061 1.49171668667467 0.245264491314213 0.486495808914857 GO:0044023 histone H4S1 kinase activity 5/255 245/18639 0.0204081632653061 1.49171668667467 0.245264491314213 0.486495808914857 GO:0044024 histone H2AS1 kinase activity 5/255 245/18639 0.0204081632653061 1.49171668667467 0.245264491314213 0.486495808914857 GO:0044025 histone H2BS14 kinase activity 5/255 245/18639 0.0204081632653061 1.49171668667467 0.245264491314213 0.486495808914857 GO:0072354 histone H3T3 kinase activity 5/255 245/18639 0.0204081632653061 1.49171668667467 0.245264491314213 0.486495808914857 GO:0072371 histone H2AS121 kinase activity 5/255 245/18639 0.0204081632653061 1.49171668667467 0.245264491314213 0.486495808914857 GO:0072518 Rho-dependent protein serine/threonine kinase activity 5/255 245/18639 0.0204081632653061 1.49171668667467 0.245264491314213 0.486495808914857 GO:0140823 histone H2BS36 kinase activity 5/255 245/18639 0.0204081632653061 1.49171668667467 0.245264491314213 0.486495808914857 GO:0140855 histone H3S57 kinase activity 5/255 245/18639 0.0204081632653061 1.49171668667467 0.245264491314213 0.486495808914857 GO:0140995 histone H2A kinase activity 5/255 245/18639 0.0204081632653061 1.49171668667467 0.245264491314213 0.486495808914857 GO:0140997 histone H4 kinase activity 5/255 245/18639 0.0204081632653061 1.49171668667467 0.245264491314213 0.486495808914857 GO:0140998 histone H2B kinase activity 5/255 245/18639 0.0204081632653061 1.49171668667467 0.245264491314213 0.486495808914857 GO:1990244 histone H2AT120 kinase activity 5/255 245/18639 0.0204081632653061 1.49171668667467 0.245264491314213 0.486495808914857 GO:0004677 DNA-dependent protein kinase activity 5/255 246/18639 0.0203252032520325 1.48565279770445 0.247814159241705 0.486495808914857 GO:0140857 histone H3T45 kinase activity 5/255 246/18639 0.0203252032520325 1.48565279770445 0.247814159241705 0.486495808914857 GO:1901981 phosphatidylinositol phosphate binding 4/255 185/18639 0.0216216216216216 1.580413354531 0.247842364329054 0.486495808914857 GO:0016278 lysine N-methyltransferase activity 2/255 70/18639 0.0285714285714286 2.08840336134454 0.248520241587351 0.486495808914857 GO:0035402 histone H3T11 kinase activity 5/255 247/18639 0.0202429149797571 1.47963800904977 0.250370742212608 0.486495808914857 GO:0001846 opsonin binding 1/255 21/18639 0.0476190476190476 3.48067226890756 0.251317740150329 0.486495808914857 GO:0009931 calcium-dependent protein serine/threonine kinase activity 1/255 21/18639 0.0476190476190476 3.48067226890756 0.251317740150329 0.486495808914857 GO:0010314 phosphatidylinositol-5-phosphate binding 1/255 21/18639 0.0476190476190476 3.48067226890756 0.251317740150329 0.486495808914857 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 1/255 21/18639 0.0476190476190476 3.48067226890756 0.251317740150329 0.486495808914857 GO:0072542 protein phosphatase activator activity 1/255 21/18639 0.0476190476190476 3.48067226890756 0.251317740150329 0.486495808914857 GO:0004679 AMP-activated protein kinase activity 5/255 248/18639 0.0201612903225806 1.47367172675522 0.252934085525177 0.488131939443405 GO:0008093 cytoskeletal anchor activity 1/255 22/18639 0.0454545454545455 3.32245989304813 0.261572008936539 0.497222467437926 GO:0015377 chloride:monoatomic cation symporter activity 1/255 22/18639 0.0454545454545455 3.32245989304813 0.261572008936539 0.497222467437926 GO:0031683 G-protein beta/gamma-subunit complex binding 1/255 22/18639 0.0454545454545455 3.32245989304813 0.261572008936539 0.497222467437926 GO:0070034 telomerase RNA binding 1/255 22/18639 0.0454545454545455 3.32245989304813 0.261572008936539 0.497222467437926 GO:0140517 protein-RNA adaptor activity 1/255 22/18639 0.0454545454545455 3.32245989304813 0.261572008936539 0.497222467437926 GO:0019902 phosphatase binding 4/255 190/18639 0.0210526315789474 1.53882352941176 0.262791436212 0.498044847671245 GO:0031072 heat shock protein binding 3/255 131/18639 0.0229007633587786 1.67391109115402 0.266692997249423 0.503930350026522 GO:0005179 hormone activity 3/255 132/18639 0.0227272727272727 1.66122994652406 0.270392083856875 0.504332770836906 GO:0019887 protein kinase regulator activity 5/255 255/18639 0.0196078431372549 1.43321799307958 0.271053804929236 0.504332770836906 GO:0017134 fibroblast growth factor binding 1/255 23/18639 0.0434782608695652 3.17800511508951 0.271686374179123 0.504332770836906 GO:0031681 G-protein beta-subunit binding 1/255 23/18639 0.0434782608695652 3.17800511508951 0.271686374179123 0.504332770836906 GO:0043274 phospholipase binding 1/255 23/18639 0.0434782608695652 3.17800511508951 0.271686374179123 0.504332770836906 GO:0099186 structural constituent of postsynapse 1/255 23/18639 0.0434782608695652 3.17800511508951 0.271686374179123 0.504332770836906 GO:0008236 serine-type peptidase activity 4/255 194/18639 0.0206185567010309 1.50709520921771 0.274872186914578 0.508754661745403 GO:0044389 ubiquitin-like protein ligase binding 6/255 322/18639 0.0186335403726708 1.36200219218122 0.279374138479131 0.509407179050237 GO:0005540 hyaluronic acid binding 1/255 24/18639 0.0416666666666667 3.04558823529412 0.281662737231569 0.509407179050237 GO:0030215 semaphorin receptor binding 1/255 24/18639 0.0416666666666667 3.04558823529412 0.281662737231569 0.509407179050237 GO:0048027 mRNA 5'-UTR binding 1/255 24/18639 0.0416666666666667 3.04558823529412 0.281662737231569 0.509407179050237 GO:0050431 transforming growth factor beta binding 1/255 24/18639 0.0416666666666667 3.04558823529412 0.281662737231569 0.509407179050237 GO:0060229 lipase activator activity 1/255 24/18639 0.0416666666666667 3.04558823529412 0.281662737231569 0.509407179050237 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 1/255 24/18639 0.0416666666666667 3.04558823529412 0.281662737231569 0.509407179050237 GO:0140612 DNA damage sensor activity 1/255 24/18639 0.0416666666666667 3.04558823529412 0.281662737231569 0.509407179050237 GO:0002020 protease binding 3/255 136/18639 0.0220588235294118 1.61237024221453 0.285241880069238 0.512541008371172 GO:0017171 serine hydrolase activity 4/255 198/18639 0.0202020202020202 1.47664884135472 0.287044328308637 0.512541008371172 GO:0022804 active transmembrane transporter activity 8/255 457/18639 0.0175054704595186 1.27954691723517 0.289299745569427 0.512541008371172 GO:0001848 complement binding 1/255 25/18639 0.04 2.92376470588235 0.291502973707849 0.512541008371172 GO:0015296 monoatomic anion:monoatomic cation symporter activity 1/255 25/18639 0.04 2.92376470588235 0.291502973707849 0.512541008371172 GO:0015645 fatty acid ligase activity 1/255 25/18639 0.04 2.92376470588235 0.291502973707849 0.512541008371172 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 1/255 25/18639 0.04 2.92376470588235 0.291502973707849 0.512541008371172 GO:0019211 phosphatase activator activity 1/255 25/18639 0.04 2.92376470588235 0.291502973707849 0.512541008371172 GO:0120515 fatty acid-CoA ligase activity 1/255 25/18639 0.04 2.92376470588235 0.291502973707849 0.512541008371172 GO:0016829 lyase activity 4/255 200/18639 0.02 1.46188235294118 0.293159967168565 0.512541008371172 GO:0046332 SMAD binding 2/255 79/18639 0.0253164556962025 1.85048399106478 0.294185725662167 0.512541008371172 GO:0070851 growth factor receptor binding 3/255 139/18639 0.0215827338129496 1.5775708844689 0.296423766451282 0.512541008371172 GO:0004529 DNA exonuclease activity 1/255 26/18639 0.0384615384615385 2.81131221719457 0.301208933829504 0.512541008371172 GO:0005160 transforming growth factor beta receptor binding 1/255 26/18639 0.0384615384615385 2.81131221719457 0.301208933829504 0.512541008371172 GO:0008143 poly(A) binding 1/255 26/18639 0.0384615384615385 2.81131221719457 0.301208933829504 0.512541008371172 GO:0008157 protein phosphatase 1 binding 1/255 26/18639 0.0384615384615385 2.81131221719457 0.301208933829504 0.512541008371172 GO:0008198 ferrous iron binding 1/255 26/18639 0.0384615384615385 2.81131221719457 0.301208933829504 0.512541008371172 GO:0015216 purine nucleotide transmembrane transporter activity 1/255 26/18639 0.0384615384615385 2.81131221719457 0.301208933829504 0.512541008371172 GO:0019865 immunoglobulin binding 1/255 26/18639 0.0384615384615385 2.81131221719457 0.301208933829504 0.512541008371172 GO:0030247 polysaccharide binding 1/255 26/18639 0.0384615384615385 2.81131221719457 0.301208933829504 0.512541008371172 GO:0043548 phosphatidylinositol 3-kinase binding 1/255 26/18639 0.0384615384615385 2.81131221719457 0.301208933829504 0.512541008371172 GO:0052742 phosphatidylinositol kinase activity 1/255 26/18639 0.0384615384615385 2.81131221719457 0.301208933829504 0.512541008371172 GO:0008168 methyltransferase activity 4/255 204/18639 0.0196078431372549 1.43321799307958 0.305441153165353 0.518349195586243 GO:0020037 heme binding 3/255 142/18639 0.0211267605633803 1.54424192212096 0.307631806049666 0.520437265270335 GO:0001671 ATPase activator activity 1/255 27/18639 0.037037037037037 2.70718954248366 0.310782442768067 0.520437265270335 GO:0004683 calcium/calmodulin-dependent protein kinase activity 1/255 27/18639 0.037037037037037 2.70718954248366 0.310782442768067 0.520437265270335 GO:0005044 scavenger receptor activity 1/255 27/18639 0.037037037037037 2.70718954248366 0.310782442768067 0.520437265270335 GO:0016405 CoA-ligase activity 1/255 27/18639 0.037037037037037 2.70718954248366 0.310782442768067 0.520437265270335 GO:0140097 catalytic activity, acting on DNA 6/255 336/18639 0.0178571428571429 1.30525210084034 0.312541214988582 0.5220015543213 GO:0019903 protein phosphatase binding 3/255 144/18639 0.0208333333333333 1.52279411764706 0.315113208360482 0.523779368274327 GO:0004860 protein kinase inhibitor activity 2/255 84/18639 0.0238095238095238 1.74033613445378 0.319423176817569 0.523779368274327 GO:0016866 intramolecular transferase activity 1/255 28/18639 0.0357142857142857 2.61050420168067 0.320225300982883 0.523779368274327 GO:0045499 chemorepellent activity 1/255 28/18639 0.0357142857142857 2.61050420168067 0.320225300982883 0.523779368274327 GO:0046875 ephrin receptor binding 1/255 28/18639 0.0357142857142857 2.61050420168067 0.320225300982883 0.523779368274327 GO:0051019 mitogen-activated protein kinase binding 1/255 28/18639 0.0357142857142857 2.61050420168067 0.320225300982883 0.523779368274327 GO:0051393 alpha-actinin binding 1/255 28/18639 0.0357142857142857 2.61050420168067 0.320225300982883 0.523779368274327 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 1/255 28/18639 0.0357142857142857 2.61050420168067 0.320225300982883 0.523779368274327 GO:0050660 flavin adenine dinucleotide binding 2/255 86/18639 0.0232558139534884 1.69986320109439 0.329461654341972 0.533499660160947 GO:0004181 metallocarboxypeptidase activity 1/255 29/18639 0.0344827586206897 2.52048681541582 0.329539284554392 0.533499660160947 GO:0099604 ligand-gated calcium channel activity 1/255 29/18639 0.0344827586206897 2.52048681541582 0.329539284554392 0.533499660160947 GO:0106222 lncRNA binding 1/255 29/18639 0.0344827586206897 2.52048681541582 0.329539284554392 0.533499660160947 GO:0008081 phosphoric diester hydrolase activity 2/255 87/18639 0.0229885057471264 1.68032454361055 0.334465945678173 0.534512082255445 GO:0019842 vitamin binding 3/255 150/18639 0.02 1.46188235294118 0.337569884964657 0.534512082255445 GO:0001965 G-protein alpha-subunit binding 1/255 30/18639 0.0333333333333333 2.43647058823529 0.338726145512943 0.534512082255445 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 1/255 30/18639 0.0333333333333333 2.43647058823529 0.338726145512943 0.534512082255445 GO:0008106 alcohol dehydrogenase (NADP+) activity 1/255 30/18639 0.0333333333333333 2.43647058823529 0.338726145512943 0.534512082255445 GO:0015215 nucleotide transmembrane transporter activity 1/255 30/18639 0.0333333333333333 2.43647058823529 0.338726145512943 0.534512082255445 GO:0031624 ubiquitin conjugating enzyme binding 1/255 30/18639 0.0333333333333333 2.43647058823529 0.338726145512943 0.534512082255445 GO:0033612 receptor serine/threonine kinase binding 1/255 30/18639 0.0333333333333333 2.43647058823529 0.338726145512943 0.534512082255445 GO:0035925 mRNA 3'-UTR AU-rich region binding 1/255 30/18639 0.0333333333333333 2.43647058823529 0.338726145512943 0.534512082255445 GO:0098918 structural constituent of synapse 1/255 30/18639 0.0333333333333333 2.43647058823529 0.338726145512943 0.534512082255445 GO:0016741 transferase activity, transferring one-carbon groups 4/255 215/18639 0.0186046511627907 1.35989056087551 0.339453170721468 0.534512082255445 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 2/255 89/18639 0.0224719101123595 1.64256444150694 0.344441341798526 0.53826297921587 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 2/255 89/18639 0.0224719101123595 1.64256444150694 0.344441341798526 0.53826297921587 GO:0046906 tetrapyrrole binding 3/255 152/18639 0.0197368421052632 1.44264705882353 0.345050159735181 0.53826297921587 GO:0016887 ATP hydrolysis activity 7/255 417/18639 0.0167865707434053 1.22699957680914 0.34552806433056 0.53826297921587 GO:0008327 methyl-CpG binding 1/255 31/18639 0.032258064516129 2.35787476280835 0.347787612163177 0.53826297921587 GO:0016878 acid-thiol ligase activity 1/255 31/18639 0.032258064516129 2.35787476280835 0.347787612163177 0.53826297921587 GO:0072349 modified amino acid transmembrane transporter activity 1/255 31/18639 0.032258064516129 2.35787476280835 0.347787612163177 0.53826297921587 GO:0140793 histone H2AXY142 phosphatase activity 2/255 90/18639 0.0222222222222222 1.6243137254902 0.349411188972213 0.539456786876612 GO:0005506 iron ion binding 3/255 154/18639 0.0194805194805195 1.42391138273491 0.352523265402651 0.540208544241079 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 2/255 91/18639 0.021978021978022 1.60646412411118 0.35436832900404 0.540208544241079 GO:0030515 snoRNA binding 1/255 32/18639 0.03125 2.28419117647059 0.356725389404062 0.540208544241079 GO:0042910 xenobiotic transmembrane transporter activity 1/255 32/18639 0.03125 2.28419117647059 0.356725389404062 0.540208544241079 GO:0043425 bHLH transcription factor binding 1/255 32/18639 0.03125 2.28419117647059 0.356725389404062 0.540208544241079 GO:0070717 poly-purine tract binding 1/255 32/18639 0.03125 2.28419117647059 0.356725389404062 0.540208544241079 GO:0071813 lipoprotein particle binding 1/255 32/18639 0.03125 2.28419117647059 0.356725389404062 0.540208544241079 GO:0071814 protein-lipid complex binding 1/255 32/18639 0.03125 2.28419117647059 0.356725389404062 0.540208544241079 GO:0043178 alcohol binding 2/255 92/18639 0.0217391304347826 1.58900255754476 0.359312180270594 0.542827231769179 GO:0051219 phosphoprotein binding 2/255 93/18639 0.021505376344086 1.5719165085389 0.364242179308662 0.547015493322099 GO:0019239 deaminase activity 1/255 33/18639 0.0303030303030303 2.21497326203209 0.365541159044625 0.547015493322099 GO:0030296 protein tyrosine kinase activator activity 1/255 33/18639 0.0303030303030303 2.21497326203209 0.365541159044625 0.547015493322099 GO:0140311 protein sequestering activity 1/255 33/18639 0.0303030303030303 2.21497326203209 0.365541159044625 0.547015493322099 GO:0008276 protein methyltransferase activity 2/255 95/18639 0.0210526315789474 1.53882352941176 0.374058455346871 0.553485409376344 GO:0008175 tRNA methyltransferase activity 1/255 34/18639 0.0294117647058824 2.14982698961938 0.374236580115442 0.553485409376344 GO:0015035 protein-disulfide reductase activity 1/255 34/18639 0.0294117647058824 2.14982698961938 0.374236580115442 0.553485409376344 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 1/255 34/18639 0.0294117647058824 2.14982698961938 0.374236580115442 0.553485409376344 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 1/255 34/18639 0.0294117647058824 2.14982698961938 0.374236580115442 0.553485409376344 GO:0004674 protein serine/threonine kinase activity 7/255 433/18639 0.0161662817551963 1.18166010052982 0.381204850282599 0.560927805667523 GO:0005154 epidermal growth factor receptor binding 1/255 35/18639 0.0285714285714286 2.08840336134454 0.38281328917594 0.560927805667523 GO:0043015 gamma-tubulin binding 1/255 35/18639 0.0285714285714286 2.08840336134454 0.38281328917594 0.560927805667523 GO:0061631 ubiquitin conjugating enzyme activity 1/255 35/18639 0.0285714285714286 2.08840336134454 0.38281328917594 0.560927805667523 GO:0008170 N-methyltransferase activity 2/255 98/18639 0.0204081632653061 1.49171668667467 0.388665893200983 0.562899422933917 GO:0004033 aldo-keto reductase (NADPH) activity 1/255 36/18639 0.0277777777777778 2.03039215686274 0.391272900617573 0.562899422933917 GO:0004869 cysteine-type endopeptidase inhibitor activity 1/255 36/18639 0.0277777777777778 2.03039215686274 0.391272900617573 0.562899422933917 GO:0005484 SNAP receptor activity 1/255 36/18639 0.0277777777777778 2.03039215686274 0.391272900617573 0.562899422933917 GO:0044390 ubiquitin-like protein conjugating enzyme binding 1/255 36/18639 0.0277777777777778 2.03039215686274 0.391272900617573 0.562899422933917 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 1/255 36/18639 0.0277777777777778 2.03039215686274 0.391272900617573 0.562899422933917 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 1/255 36/18639 0.0277777777777778 2.03039215686274 0.391272900617573 0.562899422933917 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 1/255 36/18639 0.0277777777777778 2.03039215686274 0.391272900617573 0.562899422933917 GO:0042805 actinin binding 1/255 37/18639 0.027027027027027 1.97551669316375 0.399617006962921 0.57230218417993 GO:0043394 proteoglycan binding 1/255 37/18639 0.027027027027027 1.97551669316375 0.399617006962921 0.57230218417993 GO:0016874 ligase activity 3/255 167/18639 0.0179640718562874 1.31306798168369 0.400751365888282 0.572631184215084 GO:0042887 amide transmembrane transporter activity 1/255 38/18639 0.0263157894736842 1.92352941176471 0.407847179160774 0.578931517517037 GO:0043531 ADP binding 1/255 38/18639 0.0263157894736842 1.92352941176471 0.407847179160774 0.578931517517037 GO:0008238 exopeptidase activity 2/255 102/18639 0.0196078431372549 1.43321799307958 0.407904355154184 0.578931517517037 GO:0141108 transporter regulator activity 3/255 170/18639 0.0176470588235294 1.28989619377163 0.411753981048127 0.583087852356744 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 1/255 39/18639 0.0256410256410256 1.87420814479638 0.415964966877241 0.586427225018471 GO:0016776 phosphotransferase activity, phosphate group as acceptor 1/255 39/18639 0.0256410256410256 1.87420814479638 0.415964966877241 0.586427225018471 GO:0015036 disulfide oxidoreductase activity 1/255 40/18639 0.025 1.82735294117647 0.423971898782956 0.591717278431716 GO:0071949 FAD binding 1/255 40/18639 0.025 1.82735294117647 0.423971898782956 0.591717278431716 GO:0000149 SNARE binding 2/255 106/18639 0.0188679245283019 1.37913429522752 0.42684599491228 0.591717278431716 GO:0004497 monooxygenase activity 2/255 106/18639 0.0188679245283019 1.37913429522752 0.42684599491228 0.591717278431716 GO:0008013 beta-catenin binding 2/255 106/18639 0.0188679245283019 1.37913429522752 0.42684599491228 0.591717278431716 GO:0004721 phosphoprotein phosphatase activity 3/255 175/18639 0.0171428571428571 1.25304201680672 0.429949259737636 0.591717278431716 GO:0019888 protein phosphatase regulator activity 2/255 107/18639 0.0186915887850467 1.36624518966465 0.431532195681507 0.591717278431716 GO:0001727 lipid kinase activity 1/255 41/18639 0.024390243902439 1.78278335724534 0.431869482836419 0.591717278431716 GO:0008227 G protein-coupled amine receptor activity 1/255 41/18639 0.024390243902439 1.78278335724534 0.431869482836419 0.591717278431716 GO:0016877 ligase activity, forming carbon-sulfur bonds 1/255 41/18639 0.024390243902439 1.78278335724534 0.431869482836419 0.591717278431716 GO:0042287 MHC protein binding 1/255 41/18639 0.024390243902439 1.78278335724534 0.431869482836419 0.591717278431716 GO:0061650 ubiquitin-like protein conjugating enzyme activity 1/255 41/18639 0.024390243902439 1.78278335724534 0.431869482836419 0.591717278431716 GO:0140828 metal cation:monoatomic cation antiporter activity 1/255 41/18639 0.024390243902439 1.78278335724534 0.431869482836419 0.591717278431716 GO:0004520 DNA endonuclease activity 1/255 42/18639 0.0238095238095238 1.74033613445378 0.439659206563524 0.597545446771108 GO:0016859 cis-trans isomerase activity 1/255 42/18639 0.0238095238095238 1.74033613445378 0.439659206563524 0.597545446771108 GO:0051879 Hsp90 protein binding 1/255 42/18639 0.0238095238095238 1.74033613445378 0.439659206563524 0.597545446771108 GO:0005319 lipid transporter activity 3/255 178/18639 0.0168539325842697 1.2319233311302 0.440770659596545 0.597545446771108 GO:0004620 phospholipase activity 2/255 109/18639 0.018348623853211 1.34117647058824 0.440843165311386 0.597545446771108 GO:1902936 phosphatidylinositol bisphosphate binding 2/255 111/18639 0.018018018018018 1.31701112877583 0.450070150094288 0.608748728653171 GO:0001046 core promoter sequence-specific DNA binding 1/255 44/18639 0.0227272727272727 1.66122994652406 0.45492092263018 0.610095220391746 GO:0001223 transcription coactivator binding 1/255 44/18639 0.0227272727272727 1.66122994652406 0.45492092263018 0.610095220391746 GO:0030020 extracellular matrix structural constituent conferring tensile strength 1/255 44/18639 0.0227272727272727 1.66122994652406 0.45492092263018 0.610095220391746 GO:0043014 alpha-tubulin binding 1/255 44/18639 0.0227272727272727 1.66122994652406 0.45492092263018 0.610095220391746 GO:0061135 endopeptidase regulator activity 3/255 184/18639 0.016304347826087 1.19175191815857 0.462170757039178 0.616203232155417 GO:0046915 transition metal ion transmembrane transporter activity 1/255 45/18639 0.0222222222222222 1.6243137254902 0.462395790321996 0.616203232155417 GO:0141110 transporter inhibitor activity 1/255 45/18639 0.0222222222222222 1.6243137254902 0.462395790321996 0.616203232155417 GO:0030291 protein serine/threonine kinase inhibitor activity 1/255 46/18639 0.0217391304347826 1.58900255754476 0.469768548925195 0.624713217373211 GO:0046943 carboxylic acid transmembrane transporter activity 3/255 188/18639 0.0159574468085106 1.16639549436796 0.476240623785584 0.62803196076495 GO:0005504 fatty acid binding 1/255 47/18639 0.0212765957446809 1.55519399249061 0.477040587865876 0.62803196076495 GO:0043495 protein-membrane adaptor activity 1/255 47/18639 0.0212765957446809 1.55519399249061 0.477040587865876 0.62803196076495 GO:0140359 ABC-type transporter activity 1/255 47/18639 0.0212765957446809 1.55519399249061 0.477040587865876 0.62803196076495 GO:0019208 phosphatase regulator activity 2/255 117/18639 0.0170940170940171 1.24947209653092 0.477224918053619 0.62803196076495 GO:0004175 endopeptidase activity 6/255 405/18639 0.0148148148148148 1.08287581699346 0.479691702069649 0.628716839133608 GO:0005342 organic acid transmembrane transporter activity 3/255 189/18639 0.0158730158730159 1.16022408963585 0.479731806163559 0.628716839133608 GO:0008188 neuropeptide receptor activity 1/255 48/18639 0.0208333333333333 1.52279411764706 0.484213277737552 0.633278935553451 GO:0035254 glutamate receptor binding 1/255 49/18639 0.0204081632653061 1.49171668667467 0.491287970555416 0.641206773941399 GO:0003697 single-stranded DNA binding 2/255 121/18639 0.0165289256198347 1.20816723383568 0.494870457758895 0.644553497451401 GO:0015605 organophosphate ester transmembrane transporter activity 1/255 50/18639 0.02 1.46188235294118 0.498266000007184 0.646233135437748 GO:0048020 CCR chemokine receptor binding 1/255 50/18639 0.02 1.46188235294118 0.498266000007184 0.646233135437748 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 2/255 122/18639 0.0163934426229508 1.19826422372228 0.499222753916365 0.646233135437748 GO:0016830 carbon-carbon lyase activity 1/255 51/18639 0.0196078431372549 1.43321799307958 0.50514868170056 0.652569623502969 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 1/255 52/18639 0.0192307692307692 1.40565610859729 0.51193731340738 0.658651055664373 GO:0030159 signaling receptor complex adaptor activity 1/255 52/18639 0.0192307692307692 1.40565610859729 0.51193731340738 0.658651055664373 GO:0016791 phosphatase activity 4/255 273/18639 0.0146520146520147 1.07097608274079 0.51527005388325 0.65922650595929 GO:0004864 protein phosphatase inhibitor activity 1/255 53/18639 0.0188679245283019 1.37913429522752 0.518633175304465 0.65922650595929 GO:0005544 calcium-dependent phospholipid binding 1/255 53/18639 0.0188679245283019 1.37913429522752 0.518633175304465 0.65922650595929 GO:0017046 peptide hormone binding 1/255 53/18639 0.0188679245283019 1.37913429522752 0.518633175304465 0.65922650595929 GO:0034212 protein N-acetyltransferase activity 1/255 53/18639 0.0188679245283019 1.37913429522752 0.518633175304465 0.65922650595929 GO:0051018 protein kinase A binding 1/255 53/18639 0.0188679245283019 1.37913429522752 0.518633175304465 0.65922650595929 GO:1901681 sulfur compound binding 4/255 275/18639 0.0145454545454545 1.0631871657754 0.521004929488493 0.659673326634358 GO:0015485 cholesterol binding 1/255 54/18639 0.0185185185185185 1.35359477124183 0.525237530211242 0.659673326634358 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 1/255 54/18639 0.0185185185185185 1.35359477124183 0.525237530211242 0.659673326634358 GO:0017069 snRNA binding 1/255 54/18639 0.0185185185185185 1.35359477124183 0.525237530211242 0.659673326634358 GO:0050661 NADP binding 1/255 54/18639 0.0185185185185185 1.35359477124183 0.525237530211242 0.659673326634358 GO:0140463 chromatin-protein adaptor activity 1/255 54/18639 0.0185185185185185 1.35359477124183 0.525237530211242 0.659673326634358 GO:0035591 signaling adaptor activity 2/255 129/18639 0.0155038759689922 1.13324213406293 0.529008796979809 0.662457152613461 GO:0001217 DNA-binding transcription repressor activity 4/255 278/18639 0.0143884892086331 1.05171392297926 0.529547107776321 0.662457152613461 GO:0140313 molecular sequestering activity 1/255 55/18639 0.0181818181818182 1.32898395721925 0.531751623824163 0.663902914952061 GO:0016298 lipase activity 2/255 130/18639 0.0153846153846154 1.12452488687783 0.533165182810858 0.664357402990695 GO:0019212 phosphatase inhibitor activity 1/255 56/18639 0.0178571428571429 1.30525210084034 0.53817668494797 0.667972238376598 GO:0030170 pyridoxal phosphate binding 1/255 56/18639 0.0178571428571429 1.30525210084034 0.53817668494797 0.667972238376598 GO:0005516 calmodulin binding 3/255 207/18639 0.0144927536231884 1.05933503836317 0.540572120125921 0.669351455237488 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 2/255 132/18639 0.0151515151515152 1.10748663101604 0.54140275684296 0.669351455237488 GO:0015932 nucleobase-containing compound transmembrane transporter activity 1/255 57/18639 0.0175438596491228 1.28235294117647 0.544513925723855 0.670578433819456 GO:0070279 vitamin B6 binding 1/255 57/18639 0.0175438596491228 1.28235294117647 0.544513925723855 0.670578433819456 GO:0004518 nuclease activity 3/255 209/18639 0.0143540669856459 1.04919786096257 0.54707960094726 0.672429878445855 GO:0051087 protein-folding chaperone binding 2/255 134/18639 0.0149253731343284 1.09095697980685 0.54953946826643 0.673787738684544 GO:0008094 ATP-dependent activity, acting on DNA 3/255 210/18639 0.0142857142857143 1.04420168067227 0.550313208372685 0.673787738684544 GO:0036002 pre-mRNA binding 1/255 59/18639 0.0169491525423729 1.23888334995015 0.556929712826346 0.67873996737176 GO:0070888 E-box binding 1/255 59/18639 0.0169491525423729 1.23888334995015 0.556929712826346 0.67873996737176 GO:0140789 histone phosphatase activity 2/255 136/18639 0.0147058823529412 1.07491349480969 0.557574696735095 0.67873996737176 GO:0016922 nuclear receptor binding 2/255 137/18639 0.0145985401459854 1.06706741090597 0.561554090590468 0.68142583393342 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 1/255 60/18639 0.0166666666666667 1.21823529411765 0.563010602128244 0.68142583393342 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1/255 60/18639 0.0166666666666667 1.21823529411765 0.563010602128244 0.68142583393342 GO:0016836 hydro-lyase activity 1/255 61/18639 0.0163934426229508 1.19826422372228 0.569008357467999 0.686577319576108 GO:0030295 protein kinase activator activity 2/255 139/18639 0.0143884892086331 1.05171392297926 0.569436165525208 0.686577319576108 GO:1901682 sulfur compound transmembrane transporter activity 1/255 63/18639 0.0158730158730159 1.16022408963585 0.580758979462448 0.698858649271597 GO:0001664 G protein-coupled receptor binding 4/255 297/18639 0.0134680134680135 0.984432560903149 0.581830186676354 0.698858649271597 GO:0038024 cargo receptor activity 1/255 65/18639 0.0153846153846154 1.12452488687783 0.592190452878144 0.708912146801802 GO:0005525 GTP binding 5/255 378/18639 0.0132275132275132 0.966853408029879 0.59244000893863 0.708912146801802 GO:0015085 calcium ion transmembrane transporter activity 2/255 147/18639 0.0136054421768707 0.994477791116447 0.599936500730737 0.715436368193487 GO:0061134 peptidase regulator activity 3/255 226/18639 0.0132743362831858 0.970275897969807 0.60015278279738 0.715436368193487 GO:0008173 RNA methyltransferase activity 1/255 67/18639 0.0149253731343284 1.09095697980685 0.603311412634709 0.715542601382804 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 1/255 67/18639 0.0149253731343284 1.09095697980685 0.603311412634709 0.715542601382804 GO:0019209 kinase activator activity 2/255 148/18639 0.0135135135135135 0.987758346581876 0.603633095005399 0.715542601382804 GO:0032934 sterol binding 1/255 68/18639 0.0147058823529412 1.07491349480969 0.608758084494398 0.719078959492111 GO:0000287 magnesium ion binding 3/255 230/18639 0.0130434782608696 0.953401534526854 0.612035298750473 0.719078959492111 GO:0008080 N-acetyltransferase activity 1/255 69/18639 0.0144927536231884 1.05933503836317 0.614130260922912 0.719078959492111 GO:0000510 H3-H4 histone complex chaperone activity 2/255 151/18639 0.0132450331125828 0.968134008570316 0.614568273436386 0.719078959492111 GO:0140584 chromatin extrusion motor activity 2/255 151/18639 0.0132450331125828 0.968134008570316 0.614568273436386 0.719078959492111 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 2/255 151/18639 0.0132450331125828 0.968134008570316 0.614568273436386 0.719078959492111 GO:0140849 ATP-dependent H2AZ histone chaperone activity 2/255 151/18639 0.0132450331125828 0.968134008570316 0.614568273436386 0.719078959492111 GO:0015616 DNA translocase activity 2/255 152/18639 0.0131578947368421 0.961764705882353 0.618161848285735 0.720619613194973 GO:0140674 ATP-dependent histone chaperone activity 2/255 152/18639 0.0131578947368421 0.961764705882353 0.618161848285735 0.720619613194973 GO:0061775 cohesin loader activity 2/255 153/18639 0.0130718954248366 0.955478662053057 0.62172971683201 0.72344652712254 GO:0140299 molecular sensor activity 1/255 71/18639 0.0140845070422535 1.02949461474731 0.624655173452969 0.725516926230696 GO:0140658 ATP-dependent chromatin remodeler activity 2/255 158/18639 0.0126582278481013 0.92524199553239 0.639184580611249 0.739738914841577 GO:0035064 methylated histone binding 1/255 74/18639 0.0135135135135135 0.987758346581876 0.639908756138365 0.739738914841577 GO:0019001 guanyl nucleotide binding 5/255 400/18639 0.0125 0.913676470588235 0.642259300950344 0.739738914841577 GO:0032561 guanyl ribonucleotide binding 5/255 400/18639 0.0125 0.913676470588235 0.642259300950344 0.739738914841577 GO:0003725 double-stranded RNA binding 1/255 75/18639 0.0133333333333333 0.974588235294118 0.644854798001264 0.739738914841577 GO:0003689 DNA clamp loader activity 2/255 160/18639 0.0125 0.913676470588235 0.64598785856005 0.739738914841577 GO:0099106 ion channel regulator activity 2/255 160/18639 0.0125 0.913676470588235 0.64598785856005 0.739738914841577 GO:0005539 glycosaminoglycan binding 3/255 242/18639 0.012396694214876 0.906125425376762 0.646249004593036 0.739738914841577 GO:0098631 cell adhesion mediator activity 1/255 76/18639 0.0131578947368421 0.961764705882353 0.649733166160587 0.741047016539913 GO:0140034 methylation-dependent protein binding 1/255 76/18639 0.0131578947368421 0.961764705882353 0.649733166160587 0.741047016539913 GO:0008083 growth factor activity 2/255 162/18639 0.0123456790123457 0.90239651416122 0.65268963450763 0.743080105473615 GO:0003724 RNA helicase activity 1/255 77/18639 0.012987012987013 0.949274255156608 0.654544782959006 0.743854304511761 GO:0140713 histone chaperone activity 2/255 164/18639 0.0121951219512195 0.891391678622669 0.659290377828518 0.746582168900264 GO:0015103 inorganic anion transmembrane transporter activity 2/255 165/18639 0.0121212121212121 0.885989304812834 0.662553022513783 0.746582168900264 GO:0008186 ATP-dependent activity, acting on RNA 1/255 79/18639 0.0126582278481013 0.92524199553239 0.663971389403959 0.746582168900264 GO:0016835 carbon-oxygen lyase activity 1/255 79/18639 0.0126582278481013 0.92524199553239 0.663971389403959 0.746582168900264 GO:0033293 monocarboxylic acid binding 1/255 79/18639 0.0126582278481013 0.92524199553239 0.663971389403959 0.746582168900264 GO:0042277 peptide binding 3/255 249/18639 0.0120481927710843 0.880652019844082 0.665201174186017 0.746582168900264 GO:0140104 molecular carrier activity 3/255 249/18639 0.0120481927710843 0.880652019844082 0.665201174186017 0.746582168900264 GO:0003924 GTPase activity 4/255 331/18639 0.0120845921450151 0.883312599964457 0.666515684539787 0.74673350144015 GO:0000049 tRNA binding 1/255 80/18639 0.0125 0.913676470588235 0.668588161801695 0.747731990142179 GO:0016247 channel regulator activity 2/255 168/18639 0.0119047619047619 0.870168067226891 0.672190887886309 0.750173814982171 GO:0030971 receptor tyrosine kinase binding 1/255 81/18639 0.0123456790123457 0.90239651416122 0.673141748672786 0.750173814982171 GO:0030165 PDZ domain binding 1/255 83/18639 0.0120481927710843 0.880652019844082 0.682062799753954 0.758779880921359 GO:0008201 heparin binding 2/255 172/18639 0.0116279069767442 0.849931600547196 0.684694077691893 0.759635359288729 GO:0004527 exonuclease activity 1/255 84/18639 0.0119047619047619 0.870168067226891 0.686431951837525 0.759635359288729 GO:0180051 translation factor activity 1/255 84/18639 0.0119047619047619 0.870168067226891 0.686431951837525 0.759635359288729 GO:0140030 modification-dependent protein binding 2/255 173/18639 0.0115606936416185 0.845018701122067 0.687758406664768 0.759774993750084 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 1/255 86/18639 0.0116279069767442 0.849931600547196 0.694991643162985 0.76642806641493 GO:0003730 mRNA 3'-UTR binding 3/255 262/18639 0.0114503816793893 0.836955545577009 0.698421776363447 0.768871277283586 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 4/255 349/18639 0.0114613180515759 0.83775493005225 0.706341386756296 0.776052203274892 GO:0003727 single-stranded RNA binding 1/255 89/18639 0.0112359550561798 0.82128222075347 0.707396716097334 0.776052203274892 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 3/255 268/18639 0.0111940298507463 0.818217734855136 0.712892169874093 0.780727929983219 GO:0008514 organic anion transmembrane transporter activity 3/255 269/18639 0.0111524163568773 0.815176033238574 0.715251394693279 0.78195877865431 GO:0015276 ligand-gated monoatomic ion channel activity 2/255 186/18639 0.010752688172043 0.78595825426945 0.725408394190875 0.790668043841413 GO:0016410 N-acyltransferase activity 1/255 94/18639 0.0106382978723404 0.777596996245307 0.726964931304427 0.790668043841413 GO:0042562 hormone binding 1/255 94/18639 0.0106382978723404 0.777596996245307 0.726964931304427 0.790668043841413 GO:0022834 ligand-gated channel activity 2/255 188/18639 0.0106382978723404 0.777596996245307 0.730848552860733 0.792169749932952 GO:0140597 protein carrier chaperone 2/255 188/18639 0.0106382978723404 0.777596996245307 0.730848552860733 0.792169749932952 GO:0016407 acetyltransferase activity 1/255 96/18639 0.0104166666666667 0.761397058823529 0.734422156176967 0.794682435658154 GO:0030594 neurotransmitter receptor activity 1/255 97/18639 0.0103092783505155 0.753547604608854 0.738074334906131 0.797271423200649 GO:0042626 ATPase-coupled transmembrane transporter activity 1/255 98/18639 0.0102040816326531 0.745858343337335 0.741676483789689 0.799797639248506 GO:0043130 ubiquitin binding 1/255 100/18639 0.01 0.730941176470588 0.748733413456772 0.806034439996831 GO:0015291 secondary active transmembrane transporter activity 3/255 287/18639 0.0104529616724739 0.764050010248002 0.755195123309282 0.811610378700807 GO:0003714 transcription corepressor activity 2/255 204/18639 0.00980392156862745 0.716608996539792 0.771158777969245 0.827361875346665 GO:0005496 steroid binding 1/255 108/18639 0.00925925925925926 0.676797385620915 0.775092025273714 0.830174707272862 GO:0043022 ribosome binding 1/255 112/18639 0.00892857142857143 0.652626050420168 0.787219382021801 0.841739643276689 GO:0001221 transcription coregulator binding 1/255 115/18639 0.00869565217391304 0.635601023017903 0.795885414434645 0.84957077122619 GO:0015294 solute:monoatomic cation symporter activity 1/255 116/18639 0.00862068965517241 0.630121703853955 0.798695240569345 0.851134827071372 GO:0140297 DNA-binding transcription factor binding 5/255 488/18639 0.0102459016393443 0.748915139826422 0.800987994197566 0.852143529961444 GO:0032182 ubiquitin-like protein binding 1/255 120/18639 0.00833333333333333 0.609117647058823 0.809554469904456 0.859712270256837 GO:0004540 RNA nuclease activity 1/255 121/18639 0.00826446280991736 0.604083616917842 0.812176836672336 0.859712270256837 GO:0015108 chloride transmembrane transporter activity 1/255 121/18639 0.00826446280991736 0.604083616917842 0.812176836672336 0.859712270256837 GO:0004519 endonuclease activity 1/255 127/18639 0.0078740157480315 0.575544233441408 0.827172648782839 0.874124017828943 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 1/255 128/18639 0.0078125 0.571047794117647 0.829553319405158 0.875178751972442 GO:0005125 cytokine activity 2/255 234/18639 0.00854700854700855 0.62473604826546 0.832743428228988 0.877082512593926 GO:0005262 calcium channel activity 1/255 131/18639 0.00763358778625954 0.557970363718006 0.836501111930528 0.879576750584758 GO:0015297 antiporter activity 1/255 135/18639 0.00740740740740741 0.541437908496732 0.845327933427539 0.887384049518461 GO:0099094 ligand-gated monoatomic cation channel activity 1/255 136/18639 0.00735294117647059 0.537456747404844 0.84745943888452 0.887817673080928 GO:0005261 monoatomic cation channel activity 3/255 341/18639 0.00879765395894428 0.643056753493186 0.848546117241645 0.887817673080928 GO:0140101 catalytic activity, acting on a tRNA 1/255 139/18639 0.00719424460431655 0.525856961489632 0.853679988753663 0.891072253812084 GO:0042393 histone binding 2/255 247/18639 0.00809716599190283 0.59185520361991 0.854472129642868 0.891072253812084 GO:0005216 monoatomic ion channel activity 4/255 448/18639 0.00892857142857143 0.652626050420168 0.86489415106759 0.899928247928131 GO:0046873 metal ion transmembrane transporter activity 4/255 450/18639 0.00888888888888889 0.649725490196079 0.867152866255839 0.899928247928131 GO:0015293 symporter activity 1/255 146/18639 0.00684931506849315 0.500644641418211 0.86722943323248 0.899928247928131 GO:0008509 monoatomic anion transmembrane transporter activity 1/255 149/18639 0.00671140939597315 0.490564547966838 0.872646657132086 0.90406764969658 GO:0004386 helicase activity 1/255 155/18639 0.00645161290322581 0.47157495256167 0.882829425259896 0.910871779587386 GO:0016757 glycosyltransferase activity 2/255 267/18639 0.00749063670411985 0.547521480502313 0.882923302178491 0.910871779587386 GO:0046982 protein heterodimerization activity 3/255 369/18639 0.00813008130081301 0.594261119081779 0.883531236440213 0.910871779587386 GO:0015079 potassium ion transmembrane transporter activity 1/255 160/18639 0.00625 0.456838235294118 0.890692566238999 0.916761616958189 GO:0004866 endopeptidase inhibitor activity 1/255 161/18639 0.0062111801242236 0.454000730727073 0.892200948489611 0.916823377262863 GO:0015081 sodium ion transmembrane transporter activity 1/255 164/18639 0.00609756097560976 0.445695839311334 0.896602820979221 0.919853461393593 GO:0015631 tubulin binding 3/255 385/18639 0.00779220779220779 0.569564553093965 0.900130261520677 0.921004742906896 GO:0140098 catalytic activity, acting on RNA 3/255 387/18639 0.00775193798449612 0.566621067031464 0.902048692581443 0.921004742906896 GO:0005201 extracellular matrix structural constituent 1/255 168/18639 0.00595238095238095 0.435084033613445 0.902194693558886 0.921004742906896 GO:0030414 peptidase inhibitor activity 1/255 169/18639 0.00591715976331361 0.432509571876088 0.903544937354159 0.921004742906896 GO:0001216 DNA-binding transcription activator activity 4/255 491/18639 0.00814663951120163 0.59547142685995 0.906799785615714 0.922836437772905 GO:0043021 ribonucleoprotein complex binding 1/255 177/18639 0.00564971751412429 0.41296111665005 0.913699353509858 0.928365474753997 GO:0022836 gated channel activity 2/255 318/18639 0.00628930817610063 0.459711431742508 0.933855628344508 0.947324699907169 GO:0004842 ubiquitin-protein transferase activity 3/255 449/18639 0.0066815144766147 0.488379405214202 0.947254367355488 0.959379223257638 GO:0061630 ubiquitin protein ligase activity 2/255 353/18639 0.0056657223796034 0.414130978170305 0.955804898736917 0.966492812940046 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 1/255 229/18639 0.00436681222707424 0.319188286668379 0.958170956791965 0.96734005685696 GO:0019787 ubiquitin-like protein transferase activity 3/255 479/18639 0.00626304801670146 0.457791968561955 0.961336570277631 0.968990523862644 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 3/255 484/18639 0.00619834710743802 0.453062712688381 0.963310215206992 0.969204022708075 GO:0061659 ubiquitin-like protein ligase activity 2/255 372/18639 0.00537634408602151 0.392979127134725 0.964610638714198 0.969204022708075 GO:0016755 aminoacyltransferase activity 3/255 496/18639 0.00604838709677419 0.442101518026565 0.967668335934713 0.970735430501859 GO:0008017 microtubule binding 1/255 276/18639 0.0036231884057971 0.264833759590793 0.978302235751761 0.979850182327317 GO:0003712 transcription coregulator activity 2/255 495/18639 0.00404040404040404 0.295329768270945 0.991974354129257 0.991974354129257