category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	56/1146	205/9376	2.23494657983229	MT-ATP8/MT-ND1/MT-ATP6/ACE/MT-ND4/MT-CYB/MT-ND5/MT-ND2/CTSD/MT-CO1/PIK3CB/SLC25A4/INSR/ATP5PD/NDUFA3/RAC1/SMAD3/MAPK14/PTPA/MPC1/GAPDH/MT-ND4L/MAPK13/MT-CO2/IRS1/NDUFS1/CAMK2B/PRKCZ/COX5B/COX6B1/NDUFB4/NDUFA7/NDUFS5/UQCRC1/NOS3/SLC2A1/NDUFA2/PDK4/VDAC2/ATP2A2/NDUFS3/NDUFB5/NDUFA12/NDUFB8/UQCRFS1/UQCR10/CPT2/COX6A1/NDUFA1/COX7B/UQCRQ/CAMK2G/UQCR11/PIK3R3/CD36/COX7C	6.67105905016102
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	41/1146	138/9376	2.43073576649721	MT-ATP8/MT-ND1/MT-ATP6/MT-ND4/MT-CYB/MT-ND5/MT-ND2/MT-CO1/ATP6V1A/ATP5PD/NDUFA3/MT-ND4L/ATP6V0E1/ATP6V1C2/MT-CO2/NDUFS1/ATP6V1D/COX5B/COX6B1/NDUFB4/NDUFA7/NDUFS5/COX17/ATP6V0C/UQCRC1/ATP5MF/NDUFA2/NDUFS3/NDUFB5/NDUFA12/NDUFB8/UQCRFS1/UQCR10/COX6A1/NDUFA1/COX7B/UQCRQ/COX15/UQCR11/ATP6V1F/COX7C	6.31812229176786
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	56/1146	227/9376	2.01834382760185	MT-ATP8/MT-ND1/MET/MT-ATP6/MT-ND4/MT-CYB/MT-ND5/MT-ND2/SLC26A2/AHR/MGST2/MT-CO1/PIK3CB/EPHX1/SOD2/SLC25A4/MGST1/ATP5PD/NDUFA3/RAC1/MAPK14/MT-ND4L/MAPK13/VEGFA/MT-CO2/ARNT/NDUFS1/COX5B/COX6B1/AKR1A1/NDUFB4/NDUFA7/NDUFS5/MGST3/GSTO1/UQCRC1/MAP2K7/KEAP1/NDUFA2/VDAC2/PRKD1/NDUFS3/NDUFB5/NDUFA12/NDUFB8/UQCRFS1/UQCR10/COX6A1/NDUFA1/COX7B/UQCRQ/UQCR11/PIK3R3/PLD2/COX7C/HMOX1	5.79560234662312
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	54/1146	235/9376	1.88000445583157	MT-ATP8/MT-ND1/MT-ATP6/MT-ND4/MT-CYB/MT-ND5/MT-ND2/MGLL/MT-CO1/ADCY9/ATP5PD/RPS6KA2/NDUFA3/RHEB/MAPK14/MT-ND4L/MAPK13/FGFR1/MT-CO2/NDUFS1/COX19/KDM3A/PPARGC1A/TSC1/COX5B/COX6B1/NDUFB4/GNAS/NDUFA7/NDUFS5/COX17/UQCRC1/PRKAG1/ATP5MF/NDUFA2/RPS6KB2/PRKAB1/NDUFAF1/NDUFS3/NDUFB5/NDUFA12/NDUFB8/UQCRFS1/UQCR10/CPT2/COX6A1/NDUFA1/COX7B/UQCRQ/COX15/UQCR11/RPS6KA6/BMP8B/COX7C	5.09800171514387
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	40/1146	157/9376	2.08445882104468	MT-CYB/IL6R/MT-CO1/PIK3CB/ERN1/INSR/NDUFA3/RAC1/ADIPOR1/LEPR/MAPK14/MAPK13/MT-CO2/IRS1/NDUFS1/CASP8/COX5B/XBP1/COX6B1/NDUFB4/NDUFA7/NDUFS5/UQCRC1/PRKAG1/NDUFA2/PRKAB1/NDUFS3/NDUFB5/NDUFA12/NDUFB8/UQCRFS1/UQCR10/COX6A1/NDUFA1/COX7B/UQCRQ/DDIT3/UQCR11/PIK3R3/COX7C	5.11327339179978
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	31/1146	110/9376	2.3056957004601	IL6R/EPAS1/PFKP/PIK3CB/MKNK2/HKDC1/ERBB2/PFKFB3/INSR/LTBR/LDHA/GAPDH/VEGFA/LDHC/EGLN3/ARNT/TLR4/CAMK2B/EIF4E2/NOS3/PDK1/SLC2A1/CDKN1A/RPS6KB2/CAMK2G/ALDOA/PIK3R3/LDHAL6A/EDN1/ENO2/HMOX1	5.14008378364956
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	63/1146	308/9376	1.67348881485007	MT-ATP8/MT-ND1/MT-ATP6/MT-ND4/MT-CYB/HAP1/MT-ND5/MT-ND2/MT-CO1/ERN1/SOD2/WIPI2/SLC25A4/DNAH1/ATP5PD/REST/NDUFA3/ATG14/TUBA1C/WIPI1/PSMD4/MT-ND4L/DNAH5/TUBB8/MT-CO2/DNAH6/CLTA/NDUFS1/PPARGC1A/CASP8/COX5B/GPX3/ADRM1/ATG13/COX6B1/NDUFB4/TUBB4B/NDUFA7/NDUFS5/PIK3R4/UQCRC1/MAP2K7/NDUFA2/VDAC2/NDUFS3/NDUFB5/NDUFA12/NDUFB8/TUBB2A/UQCRFS1/DNAH7/UQCR10/SLC1A3/COX6A1/NDUFA1/ITPR1/COX7B/TBP/ACTR1B/UQCRQ/UQCR11/STX1A/COX7C	4.48464447296372
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	40/1146	170/9376	1.92505902884714	CLDN1/F11R/CLDN4/MYH14/ACTN4/CLDN7/PARD6B/RAPGEF6/CLDN3/CTTN/TJP1/ERBB2/YBX3/RUNX1/WHAMM/MYL12A/RAC1/PRKCI/NEDD4L/TUBA1C/PPP2R1B/ACTR3C/MAP3K1/MARVELD3/MYL12B/PPP2R2D/PRKCZ/ARPC1B/CRB3/PRKAG1/CLDN12/MAP2K7/CLDN10/PRKAB1/CLDN16/MYL6B/CFTR/AMOTL2/CLDN8/CLDN22	4.54188831967179
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	74/1146	388/9376	1.56038934168151	MT-ATP8/MT-ND1/MT-ATP6/MT-ND4/MT-CYB/MT-ND5/MT-ND2/BACE2/MCU/FZD6/MT-CO1/PIK3CB/ERN1/RTN3/WIPI2/SLC25A4/INSR/ATP5PD/NDUFA3/PSENEN/PSEN1/ATG14/TUBA1C/WIPI1/WNT2B/PSMD4/NAE1/GAPDH/MT-ND4L/CAPN2/TUBB8/MT-CO2/IRS1/NDUFS1/APC/CASP8/COX5B/XBP1/ADRM1/ATG13/COX6B1/NDUFB4/TUBB4B/NDUFA7/NDUFS5/PIK3R4/UQCRC1/SLC39A3/MAP2K7/NDUFA2/VDAC2/ATP2A2/NDUFS3/SLC39A1/NDUFB5/NDUFA12/NDUFB8/TUBB2A/UQCRFS1/UQCR10/COX6A1/NDUFA1/ITPR1/COX7B/FADD/UQCRQ/DDIT3/PSEN2/UQCR11/PIK3R3/FZD8/CHRFAM7A/CDK5/COX7C	4.20680350380198
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	52/1146	250/9376	1.70175218150087	DEPTOR/OSBPL3/CTSD/CTSV/HGSNAT/ATP6V1A/VPS41/HEXA/TFEB/PLEKHM1/NEU1/FUCA1/LGMN/CLN3/ASAH1/AP4E1/SLC15A4/AP1M2/SLC38A9/GNPTG/BLOC1S5/AGA/ATP6V0E1/ATP6V1C2/DNASE2/VPS13C/CLTA/MFSD8/FIG4/NPC2/SLC29A1/ATP6V1D/OSBPL2/PLA2G15/BLOC1S1/NCOA7/AP3B2/ATP6V0C/RRAGD/AP4M1/ABCB9/GGA3/NAGA/SLC17A5/SORT1/ACP2/GM2A/LAMTOR2/CTNS/ATP6V1F/SLC11A1/SGSH	4.19654198946999
Organismal Systems	Digestive system	hsa04978	Mineral absorption	19/1146	61/9376	2.54833633736732	MT1G/MT1M/MT1F/MT1H/MT1X/SLC40A1/MT1E/MT2A/SLC5A1/SLC30A1/SLC34A2/FTH1/ATP2B4/ATP1A1/STEAP1/MT1A/STEAP2/VDR/HMOX1	4.52706597292497
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	38/1146	169/9376	1.83962741514091	DEPTOR/CTSD/DAPK1/PIK3CB/ERN1/GABARAPL1/WIPI2/VPS41/PLEKHM1/RRAS2/SH3GLB1/SQSTM1/ATG14/RHEB/WIPI1/DAPK3/STX7/BNIP3/MAP1LC3B/IRS1/ZFYVE1/C9orf72/TSC1/EPG5/ATG13/MTMR14/MAP1LC3A/PIK3R4/RRAGD/WDR45/RPS6KB2/RUBCN/TP53INP2/ATG9B/ITPR1/ATG4D/PIK3R3/DAPK2	4.11006718089597
NA	NA	hsa04382	Cornified envelope formation	45/1146	217/9376	1.69662460491712	DSP/LAMA5/KRT80/ITGB4/CLDN1/CLDN4/S100A10/JUP/S100A11/KRT7/CLDN7/CLDN3/PLEC/TJP1/DSG2/KRT23/ITGA6/KRT19/LAMC2/PPP2R1B/SPTLC3/KRT18/LAMB3/PPP2R3A/UGCG/PPP2R5A/PPP2R2D/PKP3/SLC27A4/ABHD5/FURIN/KRT8/COL17A1/S100A14/CLDN12/ELOVL1/KRT15/CLDN10/HAL/CLDN16/LAMA3/DST/CDSN/CLDN8/CLDN22	3.87420570739956
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	53/1146	268/9376	1.61798338152171	MT-ATP8/MT-ND1/MT-ATP6/MT-ND4/MT-CYB/MT-ND5/MT-ND2/MAOA/MCU/MT-CO1/ERN1/PINK1/SLC25A4/ATP5PD/NDUFA3/TUBA1C/PSMD4/MT-ND4L/TUBB8/MT-CO2/NDUFS1/CAMK2B/COX5B/XBP1/ADRM1/COX6B1/NDUFB4/TUBB4B/GNAS/NDUFA7/NDUFS5/UQCRC1/SLC39A3/KEAP1/NDUFA2/VDAC2/NDUFS3/SLC39A1/NDUFB5/NDUFA12/NDUFB8/TUBB2A/UQCRFS1/UQCR10/COX6A1/NDUFA1/ITPR1/COX7B/UQCRQ/CAMK2G/DDIT3/UQCR11/COX7C	3.83010528073429
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	68/1146	368/9376	1.51179907428485	MT-ATP8/MT-ND1/MT-ATP6/MT-ND4/MT-CYB/HAP1/MT-ND5/MT-ND2/MCU/MT-CO1/ERN1/WIPI2/PINK1/DNAH1/ATP5PD/NDUFA3/RAC1/NUP210L/ANXA11/SQSTM1/ATG14/TUBA1C/WIPI1/MAPK14/PSMD4/MT-ND4L/MAPK13/DNAH5/MAP1LC3B/TUBB8/MT-CO2/DNAH6/NDUFS1/NUP98/FIG4/C9orf72/COX5B/GPX3/XBP1/ADRM1/ATG13/COX6B1/NDUFB4/TUBB4B/NUP88/NDUFA7/NDUFS5/MAP1LC3A/PIK3R4/UQCRC1/NDUFA2/NUP93/NDUFS3/NDUFB5/NDUFA12/NDUFB8/TUBB2A/UQCRFS1/DNAH7/UQCR10/COX6A1/NDUFA1/COX7B/ACTR1B/UQCRQ/DDIT3/UQCR11/COX7C	3.73755202037074
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	42/1146	200/9376	1.71811518324607	CASP4/TNFSF10/CLDN1/CLDN4/MYH14/BAIAP2L1/CLDN7/MYO5C/CLDN3/CTTN/TJP1/MYO6/RIPK1/MYO1E/RAC1/CYTH1/TRADD/TUBA1C/MAPK14/MYO5B/ACTR3C/TLR5/CYTH2/WASF2/GAPDH/PTPN6/MAPK13/TUBB8/TLR4/CASP8/ARPC1B/TUBB4B/CLDN12/CLDN10/TUBB2A/TMBIM6/FADD/LPAR2/CLDN16/NFKBIB/CLDN8/CLDN22	3.83054381222196
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	23/1146	89/9376	2.11432045022256	LAMA5/ITGB4/SDC4/ITGA6/ITGA3/LAMC2/CD47/SDC1/LAMB3/CD44/LAMA4/DAG1/LAMC1/AGRN/LAMA3/SPP1/COL9A2/GP6/ITGB6/LAMB2/CD36/HSPG2/LAMB4	3.94135370256095
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	53/1146	275/9376	1.57679834999207	MT-ATP8/MT-ND1/MT-ATP6/MT-ND4/MT-CYB/MT-ND5/MT-ND2/MCU/MT-CO1/PIK3CB/SLC25A4/ATP5PD/NDUFA3/RAC1/TUBA1C/MAPK14/PSMD4/MT-ND4L/MAPK13/TUBB8/MT-CO2/HSPA1B/NDUFS1/LAMC1/COX5B/ADRM1/COX6B1/NDUFB4/HSPA1A/TUBB4B/NDUFA7/NDUFS5/UQCRC1/NDUFA2/VDAC2/NDUFS3/NDUFB5/NDUFA12/NDUFB8/TUBB2A/UQCRFS1/UQCR10/COX6A1/NDUFA1/ITPR1/COX7B/UQCRQ/DDIT3/UQCR11/PIK3R3/HSPA6/HSPA1L/COX7C	3.62262874200179
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	83/1146	480/9376	1.41471785922048	MT-ATP8/MT-ND1/MT-ATP6/MT-ND4/MT-CYB/HAP1/MT-ND5/MT-ND2/MCU/FZD6/MT-CO1/ERN1/WIPI2/PINK1/SLC25A4/DNAH1/ATP5PD/NDUFA3/RAC1/SQSTM1/PSEN1/ATG14/TUBA1C/WIPI1/MAPK14/WNT2B/PSMD4/MT-ND4L/MAPK13/DNAH5/MAP1LC3B/CAPN2/TUBB8/MT-CO2/DNAH6/NDUFS1/ZFYVE1/FIG4/APC/CAMK2B/C9orf72/CASP8/COX5B/GPX3/XBP1/ADRM1/ATG13/COX6B1/NDUFB4/TUBB4B/NDUFA7/NDUFS5/MAP1LC3A/PIK3R4/UQCRC1/MAP2K7/NDUFA2/VDAC2/ATP2A2/NDUFS3/NDUFB5/NDUFA12/NDUFB8/TUBB2A/UQCRFS1/DNAH7/UQCR10/COX6A1/NDUFA1/ITPR1/COX7B/FADD/ACTR1B/UQCRQ/CAMK2G/DDIT3/PSEN2/UQCR11/STX1A/FZD8/CHRFAM7A/CDK5/COX7C	3.48059906354356
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	25/1146	104/9376	1.96670694052893	AGPAT2/PLAAT3/PISD/AGPAT5/LPIN3/LPIN2/MBOAT1/DGKH/CDIPT/CRLS1/PGS1/PLPP2/CHKB/GPAT4/PLA2G6/PLA2G15/CEPT1/PLA2G12A/PNPLA6/PCYT2/DGKE/GPD1L/PLD2/PLB1/ADPRM	3.69915751233778
NA	NA	hsa04518	Integrin signaling	33/1146	154/9376	1.75317875841436	MET/FLNB/LAMA5/ITGB4/ACTN4/PIK3CB/ERBB2/C3/CDH1/ITGA6/RAC1/ITGA3/TLN1/LIMS1/LAMC2/LAMB3/VEGFA/LAMA4/LAMC1/PDGFC/VEGFB/TLN2/LAMA3/SPP1/COL9A2/PDGFA/PDGFB/PIK3R3/ITGB6/LAMB2/VEGFC/FGB/LAMB4	3.51660746903036
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	33/1146	158/9376	1.70879448604944	DEPTOR/SGK1/RNF152/FZD6/LPIN3/CASTOR2/PIK3CB/CLIP1/LPIN2/ATP6V1A/MIOS/INSR/RPS6KA2/FNIP2/RHEB/WDR59/WNT2B/SLC38A9/ATP6V1C2/IRS1/TSC1/ATP6V1D/TBC1D7/EIF4E2/RRAGD/STRADB/RPS6KB2/SLC7A5/LAMTOR2/ATP6V1F/PIK3R3/FZD8/RPS6KA6	3.35280697540197
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	47/1146	253/9376	1.51988356131311	CASP4/ACTN4/PIK3CB/RPS6KA5/DIAPH1/WIPI2/HKDC1/CTTN/C3/FNBP1/RIPK1/MYL12A/RAC1/CAST/CYTH1/TLN1/TRADD/SQSTM1/ATG14/WIPI1/MAPK14/ACTR3C/TLR5/CYTH2/BNIP3/WASF2/MAPK13/MAP1LC3B/CAPN2/MYL12B/CD44/TNIP1/TLR4/FNBP1L/ARPC1B/MAP1LC3A/PIK3R4/RRAGD/RPS6KB2/SEPTIN8/UBE2D4/ITPR1/TLN2/NFKBIB/PIK3R3/PLCD3/FOXO4	3.12806333543654
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	26/1146	122/9376	1.74359854661975	PFKP/PIK3CB/PFKFB3/INSR/HMGCR/ADIPOR1/LEPR/RHEB/PPP2R1B/PPP2R3A/SCD/PPP2R5A/IRS1/RAB11B/PPARGC1A/TSC1/PPP2R2D/EEF2K/PRKAG1/STRADB/RPS6KB2/PRKAB1/CFTR/PIK3R3/CD36/PCK1	3.0848335065531
NA	NA	hsa03272	Virion - Hepatitis viruses	13/1146	48/9376	2.21582315299593	CLDN1/CLDN4/CLDN7/CLDN3/EPCAM/CD9/SLC10A1/CLDN12/CLDN10/CLDN16/HSPG2/CLDN8/CLDN22	3.15119144539019
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	16/1146	65/9376	2.01390790710162	AGPAT2/AGPAT5/ALDH2/MGLL/LPIN3/LPIN2/MBOAT1/DGKH/ALDH3A2/PLPP2/GPAT4/AKR1A1/TKFC/DGKE/PNPLA3/LIPC	3.06080071673684
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	19/1146	83/9376	1.87287369372779	SOD2/ACOX3/PEX16/ABCD3/PEX13/ECH1/PEX11A/ABCD4/MPV17/NUDT12/EHHADH/GSTK1/PRDX5/ACOT8/MVK/PEX19/PECR/MPV17L2/PEX11G	2.98050951177095
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	15/1146	62/9376	1.97939537240331	PIK3CB/SOD2/ADCY9/INSR/HSPA1B/IRS1/HSPA1A/PRKAG1/RPS6KB2/PRKAB1/CRYAB/FOXA2/PIK3R3/HSPA6/HSPA1L	2.88711315135845
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	20/1146	93/9376	1.75946255324739	MET/ARHGAP29/ACTN4/TJP1/ERBB2/LMO7/INSR/CDH1/MYL12A/RAC1/SMAD3/WASF2/PTPN6/FGFR1/MYL12B/CTNNA1/IQGAP1/NECTIN4/SNAI1/TCF7	2.74651321798967
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	20/1146	93/9376	1.75946255324739	LAMA5/GADD45A/PIK3CB/ITGA6/ITGA3/LAMC2/RB1/LAMB3/LAMA4/CDKN2B/LAMC1/GADD45B/CKS2/CDKN1A/CCNE1/LAMA3/FHIT/PIK3R3/LAMB2/LAMB4	2.74651321798967
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	12/1146	47/9376	2.08889383981285	HAGH/ALDH2/ACSS2/LDHA/LDHC/ALDH3A2/AKR1A1/GRHPR/FH/LDHD/LDHAL6A/PCK1	2.79251138708787
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	11/1146	42/9376	2.142774038062	SAT1/SLC40A1/GCLC/FTH1/MAP1LC3B/CP/MAP1LC3A/GPX4/VDAC2/STEAP3/HMOX1	2.76967710937646
Cellular Processes	Cell motility	hsa04814	Motor proteins	35/1146	194/9376	1.47604397186089	DYNLT3/BICDL2/MYH14/MYO5C/MYO6/KIF1C/DNAH1/MYL12A/MYO1E/KIF16B/TUBA1C/MYO5B/KIF1B/KIF13B/DNAH5/TUBB8/DNAH6/MYL12B/MYO9A/DYNLRB1/KIF27/TUBD1/TUBB4B/KIF22/KIFC3/MYO3B/KIF12/TUBB2A/DNAH7/ACTR1B/MYL6B/ACTG2/TUBE1/TUBG1/KIF24	2.50009965527552
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	22/1146	109/9376	1.65131210272668	PIK3CB/PYGB/PYGL/INSR/RPS6KA2/PTPA/PPP1R3B/IRS1/PPARGC1A/PRKCZ/SLC27A4/NOS3/PRKAG1/SLC2A1/RPS6KB2/PRKAB1/SLC27A5/PIK3R3/RPS6KA6/CD36/PPP1R3C/PCK1	2.55217732134553
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	8/1146	27/9376	2.4241484066964	ACOX3/SCD/TECR/HACD1/ELOVL7/ELOVL1/ACOT7/ACOT4	2.7652384048402
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	7/1146	22/9376	2.60320482310011	MAOA/ALDH2/HNMT/ALDH3A2/ALDH3B2/CNDP2/HAL	2.80918084070111
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	10/1146	38/9376	2.15302654542114	SGK1/PIK3CB/INSR/NEDD4L/HSD11B2/SCNN1A/IRS1/FXYD4/ATP1A1/PIK3R3	2.65755461755946
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	15/1146	67/9376	1.8316792998359	PFKP/ALDH2/HKDC1/ACSS2/LDHA/GAPDH/LDHC/ALDH3A2/ALDH3B2/AKR1A1/ALDOA/BPGM/LDHAL6A/PCK1/ENO2	2.54929331900745
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	26/1146	138/9376	1.54144219338847	PIK3CB/PYGB/MKNK2/HKDC1/PYGL/INSR/PRKCI/TRIP10/FLOT1/FLOT2/RHEB/PPP1R3B/IRS1/PPARGC1A/TSC1/PRKCZ/EIF4E2/PRKAG1/RPS6KB2/PHKG2/PRKAB1/PHKA1/SOCS1/PIK3R3/PPP1R3C/PCK1	2.39100613254856
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	54/1146	333/9376	1.32672987123249	LAMA5/ITGB4/NOTCH2/FZD6/PARD6B/PIK3CB/IFNAR1/ATP6V1A/ITGA6/PRKCI/ITGA3/TRADD/PSEN1/LAMC2/RHEB/PPP2R1B/RB1/WNT2B/RBL2/ATP6V0E1/LAMB3/PPP2R3A/ATP6V1C2/VEGFA/PPP2R5A/APC/TSC1/PPP2R2D/CASP8/PRKCZ/LAMA4/LAMC1/ATP6V1D/GNAS/HES2/ATP6V0C/CRB3/CDKN1A/RPS6KB2/CCNE1/TCF7/HEY2/FADD/TBP/LAMA3/SPP1/COL9A2/ATP6V1F/PIK3R3/FZD8/ITGB6/TUBG1/LAMB2/LAMB4	2.26533649882884
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	58/1146	362/9376	1.31084820610724	MET/ERBB3/LAMA5/ITGB4/SGK1/IL6R/EFNA1/PIK3CB/IFNAR1/ERBB2/FGFR2/INSR/ITGA6/FGF18/RAC1/ITGA3/LAMC2/RHEB/PPP2R1B/RBL2/YWHAH/IL4R/LAMB3/PPP2R3A/VEGFA/GNG7/FGFR1/PPP2R5A/IRS1/TLR4/TSC1/PPP2R2D/LAMA4/LAMC1/EIF4E2/NOS3/FGF9/CDKN1A/RPS6KB2/PDGFC/YWHAB/VEGFB/CCNE1/LPAR2/LAMA3/SPP1/COL9A2/PDGFA/PHLPP1/TGFA/PDGFB/EFNA2/PIK3R3/ITGB6/LAMB2/VEGFC/PCK1/LAMB4	2.25072224457812
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	12/1146	51/9376	1.92505902884714	TJP1/ATP6V1A/ADCY9/ERO1A/ATP6V0E1/ATP6V1C2/ATP6V1D/GNAS/ATP6V0C/KCNQ1/CFTR/ATP6V1F	2.47177049335487
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	25/1146	133/9376	1.53787610387225	DEPP1/TNFSF10/BCL6/SGK1/GADD45A/CCNG2/PIK3CB/GABARAPL1/SOD2/HOMER2/INSR/SMAD3/MAPK14/RBL2/BNIP3/MAPK13/IRS1/CDKN2B/GADD45B/PRKAG1/CDKN1A/PRKAB1/PIK3R3/FOXO4/PCK1	2.3312004795262
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	15/1146	70/9376	1.75317875841436	MET/EPAS1/PIK3CB/RAC1/GAB1/VEGFA/EGLN3/ARNT/SLC2A1/CDKN1A/FH/TGFA/PDGFB/PIK3R3/PAK6	2.36017164579098
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	35/1146	203/9376	1.4106035987242	MET/FLNB/LAMA5/ITGB4/ACTN4/PIK3CB/DIAPH1/ERBB2/ITGA6/MYL12A/RAC1/ITGA3/TLN1/LAMC2/LAMB3/CAPN2/VEGFA/MYL12B/LAMA4/LAMC1/VAV2/PDGFC/VEGFB/TLN2/LAMA3/SPP1/COL9A2/PDGFA/PDGFB/PIK3R3/ITGB6/PAK6/LAMB2/VEGFC/LAMB4	2.20695309474512
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	16/1146	77/9376	1.7000521293715	GADD45A/PIK3CB/RALB/RALBP1/ERBB2/RAC1/SMAD3/RB1/RALGDS/VEGFA/GADD45B/CDKN1A/RPS6KB2/TGFA/PIK3R3/PLD2	2.30163073916152
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	15/1146	71/9376	1.72848609984514	MET/PFKP/PIK3CB/HKDC1/ERBB2/FGFR2/SLC16A3/LDHA/LDHC/FGFR1/PDK1/SLC2A1/SLC7A5/PIK3R3/LDHAL6A	2.2991657670464
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	10/1146	41/9376	1.9954880177074	DAPK1/RPS6KA5/ERBB2/CDH1/RB1/DAPK3/VEGFA/CDKN1A/HBEGF/DAPK2	2.38368483547279
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	22/1146	116/9376	1.55166395859662	CLDN1/F11R/CLDN4/ACTN4/CLDN7/PIK3CB/CLDN3/MYL12A/RAC1/MAPK14/MAPK13/CD99/MYL12B/CTNNA1/TXK/VAV2/CLDN12/CLDN10/CLDN16/PIK3R3/CLDN8/CLDN22	2.23087965142536
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	36/1146	212/9376	1.38931146893213	MET/EFNA1/PARD6B/PIK3CB/ID1/RALB/RAPGEF6/FGFR2/ADCY9/INSR/CDH1/FGF18/RAC1/PRKCI/TLN1/MAPK14/RALGDS/MAPK13/VEGFA/FGFR1/PRKCZ/GNAS/VAV2/FGF9/PDGFC/RAPGEF5/PRKD1/VEGFB/TLN2/LPAR2/PDGFA/PDGFB/EFNA2/PIK3R3/RAP1GAP/VEGFC	2.1394424942048
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	28/1146	157/9376	1.45912117473127	CD24/SGK1/ARG2/VPS41/ATP11A/RAC1/MAPK14/CD47/PTPN6/MAPK13/ARNT/CAMK2B/PLA2G6/DUSP2/BSG/PLA2G15/SLC2A1/TMEM30B/ATP2A2/SIRPA/UQCRFS1/DUSP8/ANO9/CAMK2G/ALOX5/MEGF11/CD36/RAB17	2.16477752848539
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	4/1146	10/9376	3.27260034904014	SQOR/MPST/TST/BPNT1	2.68302069000987
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	9/1146	36/9376	2.04537521815009	B3GNT3/GCNT3/GALNT1/GCNT4/ST6GALNAC1/GALNT15/C1GALT1C1/ST3GAL1/ST6GALNAC2	2.34492006111025
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	16/1146	79/9376	1.65701283495703	SLC1A1/ATP6V1A/STXBP1/STX3/ATP6V0E1/ATP6V1C2/CLTA/VAMP2/ATP6V1D/ATP6V0C/SLC1A3/SLC6A9/STX1A/ATP6V1F/SLC6A12/UNC13C	2.18823526789972
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	21/1146	112/9376	1.53403141361257	LAMA5/ITGA6/LAMC2/MAPK14/MAPK13/LAMB3/HSPA1B/IL10RB/TLR4/CASP8/LAMA4/LAMC1/HSPA1A/LAMA3/NFKBIB/SOCS1/ALOX5/LAMB2/HSPA6/HSPA1L/LAMB4	2.1215563531763
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	17/1146	87/9376	1.59868407855409	MT-CYB/MT-CO1/MT-CO2/COX5B/COX6B1/UQCRC1/ATP2A2/UQCRFS1/UQCR10/COX6A1/SLC9A1/ATP1A1/COX7B/UQCRQ/UQCR11/CACNG8/COX7C	2.09339355579078
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	8/1146	32/9376	2.04537521815009	ACOX3/ACSS2/LDHA/LDHC/PCCA/EHHADH/ACADS/LDHAL6A	2.21033858016039
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	9/1146	38/9376	1.93772389087903	SIRT7/NT5C2/PNP/BST1/SIRT5/NAPRT/NUDT12/NAMPT/NNMT	2.16131403574162
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	5/1146	16/9376	2.55671902268761	FUT2/HEXA/NAGA/ST3GAL1/B3GALNT1	2.32546779155601
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	26/1146	149/9376	1.42764444756785	MT-ND1/MT-ND4/MT-ND5/MT-ND2/GABRE/MGLL/GABRP/ADCY9/NDUFA3/MAPK14/MT-ND4L/MAPK13/GNG7/NDUFS1/DAGLB/NDUFB4/NDUFA7/NDUFS5/NDUFA2/NDUFS3/NDUFB5/NDUFA12/NDUFB8/NDUFA1/ITPR1/FAAH	1.96346760789568
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	40/1146	248/9376	1.31959691493554	ANXA2/CASP4/DYNLT3/TNFSF10/S100A10/GCC2/PIK3CB/AHNAK/MYO6/AHNAK2/VPS41/RIPK1/MYL12A/PLEKHM1/RAC1/CYTH1/FYCO1/TRADD/TUBA1C/MAPK14/ACTR3C/TLR5/CYTH2/GAPDH/MAPK13/TUBB8/MYL12B/DYNLRB1/TLR4/CASP8/ARPC1B/TUBB4B/MAP2K7/TUBB2A/TCF7/FADD/ACTR1B/RHOB/RILP/RIPK3	1.90334989526735
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	12/1146	57/9376	1.72242123633692	ACOX3/ACADSB/SCD/MECR/TECR/HACD1/ELOVL7/ACADM/ELOVL1/EHHADH/CPT2/ACADS	2.04136801328755
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	8/1146	33/9376	1.98339415093342	STX19/VTI1B/STX7/STX3/VAMP2/VAMP4/STX6/STX1A	2.11163788828983
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	7/1146	28/9376	2.04537521815009	MECR/TECR/HACD1/ELOVL7/ELOVL1/ACOT7/ACOT4	2.06714001335974
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	7/1146	28/9376	2.04537521815009	SLC12A7/ATP6V1A/ATP6V0E1/ATP6V1C2/ATP6V1D/ATP6V0C/ATP6V1F	2.06714001335974
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	5/1146	17/9376	2.40632378605893	PSTK/SEPHS2/SEPSECS/KYAT3/TXNRD2	2.16557429996607
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	10/1146	46/9376	1.77858714621747	UGT2B7/FTH1/CP/BLVRA/ALAS1/BLVRB/ALAD/COX15/MMAB/HMOX1	1.97525583320345
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	4/1146	12/9376	2.72716695753345	VKORC1L1/COQ7/COQ6/VKORC1	2.23394394192173
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	38/1146	238/9376	1.30629005528913	MET/EFNA1/PLAAT3/RALGAPA2/PIK3CB/RALB/RALBP1/KSR1/FGFR2/GAB2/INSR/ETS2/RRAS2/FGF18/RAC1/RALGDS/GAB1/VEGFA/GNG7/FGFR1/RGL2/PLA2G6/PLA2G12A/FGF9/PDGFC/RAPGEF5/KSR2/VEGFB/PDGFA/TGFA/PDGFB/EFNA2/PIK3R3/PAK6/RASAL1/PLD2/FOXO4/VEGFC	1.78596863391104
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	6/1146	23/9376	2.13430457546096	HMGCR/PDSS2/DHDDS/ICMT/MVK/RCE1	2.03233906049016
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	33/1146	204/9376	1.32347808233241	MET/ERBB3/SDC4/FZD6/PIK3CB/CTTN/ERBB2/RRAS2/RAC1/MAPK14/WNT2B/HPSE/PTPN6/MAPK13/GAB1/SDC1/VEGFA/FGFR1/CD44/IQGAP1/TLR4/CAMK2B/VAV2/CDKN1A/RPS6KB2/ITPR1/HBEGF/SLC9A1/CAMK2G/ANK2/PIK3R3/FZD8/HSPG2	1.74303436637736
Human Diseases	Cancer: specific types	hsa05218	Melanoma	14/1146	73/9376	1.56905496186856	MET/GADD45A/PIK3CB/CDH1/FGF18/RB1/FGFR1/GADD45B/FGF9/CDKN1A/PDGFC/PDGFA/PDGFB/PIK3R3	1.82130283460352
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	15/1146	80/9376	1.53403141361257	MET/ERBB3/IL6R/PIK3CB/ERBB2/FGFR2/GAB1/VEGFA/EIF4E2/RPS6KB2/PDGFC/PDGFA/TGFA/PDGFB/PIK3R3	1.78995358661266
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	46/1146	300/9376	1.25449680046539	MET/ERBB3/EFNA1/GADD45A/RPS6KA5/MKNK2/ERBB2/FGFR2/INSR/RPS6KA2/RRAS2/FGF18/RAC1/TRADD/MAPK14/ELK4/MAPK13/VEGFA/FGFR1/MAP3K1/HSPA1B/MECOM/DUSP2/HSPA1A/HSPB1/IL1RAP/MAP3K4/GADD45B/MAP3K21/FGF9/MAP2K7/PDGFC/DUSP10/VEGFB/DUSP8/PDGFA/DDIT3/TGFA/PDGFB/EFNA2/RPS6KA6/RPS6KA4/CACNG8/VEGFC/HSPA6/HSPA1L	1.67175926943067
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	7/1146	30/9376	1.90901687027341	PIGC/B3GALT4/PIGZ/PIGA/PGAP2/PIGT/PGAP3	1.860791492106
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	9/1146	43/9376	1.71240715938147	ALDH2/ACOX3/ECI1/ACADSB/ALDH3A2/ACADM/EHHADH/CPT2/ACADS	1.74714882135587
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	11/1146	56/9376	1.6070805285465	C3/TLR5/BNIP3/HSF1/HSPA1B/BCL2L13/TLR4/CASP8/HSPA1A/HSPA6/HSPA1L	1.70024063066535
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	7/1146	31/9376	1.84743568090976	PFKP/RPIA/TKT/IDNK/SHPK/RBKS/ALDOA	1.76350205180784
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	7/1146	31/9376	1.84743568090976	ALDH2/ACOX3/ALDH3A2/ALDH3B2/CNDP2/EHHADH/ACADS	1.76350205180784
NA	NA	hsa04517	IgSF CAM signaling	45/1146	299/9376	1.23132956276594	F11R/SLIT2/MYH14/CADM1/ACTN4/NTN1/CXADR/PARD6B/PIK3CB/RAPGEF6/CABLES1/TJP1/LMO7/GRIP1/CDH1/MYL12A/RAC1/PRKCI/TUBA1C/MAPK14/EPB41L1/ACTR3C/PTPN6/MAPK13/FGFR1/TUBB8/MYL12B/IQGAP1/NECTIN4/PVR/ARPC1B/TUBB4B/IL1RAP/VAV2/PLXNA2/TUBB2A/MYL6B/ANK2/SH2D1B/PIK3R3/PAK6/UNC5A/IL1RAPL2/NRP2/FGB	1.51695812641394
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	21/1146	125/9376	1.37449214659686	CTSD/PIK3CB/DEGS1/ORMDL2/GAB2/RAC1/TRADD/ASAH1/PPP2R1B/MAPK14/SPTLC3/MAPK13/PPP2R3A/PPP2R5A/PPP2R2D/PRKCZ/ACER2/NOS3/ORMDL3/PIK3R3/PLD2	1.5728286448214
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	9/1146	44/9376	1.67348881485007	PARP4/MBD4/TDG/PNKP/RFC3/RFC5/POLG2/NEIL1/LIG3	1.67088819249978
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	25/1146	154/9376	1.32816572607149	ALDH2/RDH13/VKORC1L1/UGT2B7/AFMID/AK7/GCLC/ALDH3A2/MTHFD1L/ALAS1/IDO2/AKR1A1/ALAD/NAPRT/COQ7/BCO1/AK9/FPGS/COX15/GCH1/DHRS3/COQ6/MMAB/PHOSPHO2/VKORC1	1.53221267924801
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	13/1146	71/9376	1.49802128653246	MET/F11R/TJP1/ATP6V1A/RAC1/MAPK14/MAPK13/ATP6V0E1/ATP6V1C2/ATP6V1D/ATP6V0C/HBEGF/ATP6V1F	1.57179868428407
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	7/1146	32/9376	1.78970331588133	GABARAPL1/WIPI2/WIPI1/ATG13/PIK3R4/ATG9B/ATG4D	1.66974659018794
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	14/1146	78/9376	1.46847451559493	MET/PIK3CB/CTTN/CDH1/RAC1/ACTR3C/WASF2/GAB1/CLTA/CTNNA1/ARPC1B/SEPTIN8/PIK3R3/ELMO3	1.55030279724821
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	29/1146	184/9376	1.28947568100766	MET/LIMK2/EFNA1/SLIT2/NTN1/PARD6B/PIK3CB/MYL12A/RAC1/SEMA4B/SSH3/MYL12B/CAMK2B/PRKCZ/SEMA3B/NTN4/PLXNA2/SEMA4A/RHOD/CAMK2G/EPHB6/EPHB2/EFNA2/PIK3R3/BMP7/PAK6/UNC5A/RND1/CDK5	1.47976931492881
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	17/1146	99/9376	1.4049041902445	SLC44A1/PIK3CB/DGKH/RAC1/RHEB/WASF2/RALGDS/PLPP2/CHKB/TSC1/RPS6KB2/PDGFC/DGKE/PDGFA/PDGFB/PIK3R3/PLD2	1.51127716247731
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	24/1146	149/9376	1.31782564390878	AGPAT2/AGPAT5/PIK3CB/RALB/ADCY9/DGKH/GAB2/INSR/RRAS2/CYTH1/RHEB/CYTH2/RALGDS/GAB1/PLPP2/TSC1/GNAS/PDGFC/DGKE/LPAR2/PDGFA/PDGFB/PIK3R3/PLD2	1.45925045986824
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	18/1146	107/9376	1.37632724959632	PFKP/PYGB/PYGL/LDHA/LDHC/PPARGC1A/CAMK2B/GNAS/PRKAG1/SLC2A1/PPP4C/PHKG2/PRKAB1/ITPR1/CAMK2G/PHKA1/LDHAL6A/PCK1	1.46089547400194
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	24/1146	150/9376	1.30904013961606	MET/JUP/GADD45A/FZD6/PIK3CB/ERBB2/FGFR2/CDH1/FGF18/SMAD3/RB1/WNT2B/GAB1/CTNNA1/APC/CDKN2B/GADD45B/FGF9/CDKN1A/RPS6KB2/CCNE1/TCF7/PIK3R3/FZD8	1.42374373206872
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	23/1146	144/9376	1.30676750048478	ALDH2/LPIN3/LPIN2/C3/ACOX3/RIPK1/IL17RA/ADIPOR1/TRADD/MAPK14/MAPK13/SCD/ALDH3A2/TLR4/PPARGC1A/CASP8/PRKAG1/MAP2K7/ACADM/PRKAB1/TCF7/FADD/LBP	1.38426973980993
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	35/1146	232/9376	1.23427814888367	LIMK2/ITGB4/MYH14/ACTN4/PIK3CB/DIAPH1/FGFR2/SPATA13/ITGA6/MYL12A/RRAS2/FGF18/RAC1/ITGA3/ACTR3C/RGCC/WASF2/SSH3/FGFR1/MYL12B/IQGAP1/APC/ARPC1B/VAV2/FGF9/PDGFC/ARHGEF4/SLC9A1/LPAR2/SCIN/PDGFA/PDGFB/PIK3R3/ITGB6/PAK6	1.34829739989801
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	27/1146	174/9376	1.26954323885178	ERP29/ERN1/SVIP/ERO1A/BAG1/DNAJC5/NPLOC4/CAPN2/HSPBP1/HSPA1B/MBTPS1/SELENOS/XBP1/NSFL1C/HSPA1A/DNAJB1/LMAN2/WFS1/MAP2K7/UBE2D4/CRYAB/DDIT3/KRTCAP2/HSPH1/SSR4/HSPA6/HSPA1L	1.33918316666132
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	35/1146	233/9376	1.22898081777258	DSP/ITGB4/SYNE2/MYH14/JUP/DSC2/SDC4/OBSCN/PDLIM5/DIAPH1/PLEC/TMOD1/MYOM1/DSG2/ITGA6/ITGA3/SUN1/TLN1/FMNL2/SDC1/AMPD3/DAG1/SGCD/AGRN/SDC3/INF2/MYPN/ATP1A1/TLN2/COL9A2/ANK2/ACTG2/ITGB6/HSPG2/ENO2	1.3207199318015
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	10/1146	54/9376	1.51509275418525	MPST/LDHA/TST/GCLC/LDHC/CISD1/APIP/MTAP/KYAT3/LDHAL6A	1.41646484634425
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	10/1146	55/9376	1.48754561320006	DEGS1/HEXA/NEU1/CERK/ASAH1/SPTLC3/UGCG/PLPP2/ACER2/GM2A	1.35314199700135
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	15/1146	90/9376	1.36358347876672	PIK3CB/SOD2/ADCY9/INSR/ADIPOR1/RHEB/IRS1/PPARGC1A/TSC1/ATG13/EIF4E2/PRKAG1/RPS6KB2/PRKAB1/PIK3R3	1.29326964791241
Organismal Systems	Digestive system	hsa04976	Bile secretion	15/1146	90/9376	1.36358347876672	ABCC3/SLC5A1/EPHX1/UGT2B7/ADCY9/NCEH1/HMGCR/GNAS/SLC10A1/SLC2A1/SLC9A1/ATP1A1/SLC4A5/CFTR/SLC27A5	1.29326964791241
Organismal Systems	Immune system	hsa04611	Platelet activation	20/1146	126/9376	1.29865093215879	PIK3CB/ADCY9/MYL12A/PRKCI/TLN1/MAPK14/MAPK13/MYL12B/PRKCZ/GUCY1B1/GNAS/NOS3/BTK/ITPR1/TLN2/GP6/PTGS1/PIK3R3/ADAMTS13/FGB	1.25937860272885
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	8/1146	42/9376	1.55838111859054	MAOA/ALDH2/DHTKD1/AFMID/ALDH3A2/IDO2/EHHADH/KYAT3	1.35331688589197
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	24/1146	156/9376	1.25869244193852	CLDN1/CLDN4/CLDN7/PIK3CB/CLDN3/IFNAR1/RIPK1/TRADD/PPP2R1B/RB1/YWHAH/PPP2R2D/CASP8/PSME3/CLDN12/MAVS/CDKN1A/CLDN10/YWHAB/FADD/CLDN16/PIK3R3/CLDN8/CLDN22	1.21579011616507
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	19/1146	120/9376	1.29540430482839	PIK3CB/RPS6KA5/RPS6KA2/RAC1/PSEN1/MAPK14/MAPK13/GAB1/MAP3K1/IRS1/CAMK2B/PRDM4/MAP2K7/SORT1/CAMK2G/PSEN2/NFKBIB/PIK3R3/RPS6KA6	1.21527286042818
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	22/1146	142/9376	1.26755647321977	SDC4/MGST2/PIK3CB/MGST1/RAC1/SQSTM1/MAPK14/MAPK13/SDC1/VEGFA/PRKCZ/MGST3/GSTO1/NOS3/MAP2K7/KEAP1/THBD/PDGFA/PDGFB/PIK3R3/EDN1/HMOX1	1.19878894464602
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	4/1146	17/9376	1.92505902884714	CA8/CA12/CA3/CA5A	1.42448281020471
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	4/1146	17/9376	1.92505902884714	MYH14/PCDH1/DAG1/NRP2	1.42448281020471
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	24/1146	157/9376	1.2506752926268	GADD45A/MCU/PIK3CB/SLC25A4/RRAS2/SMAD3/SQSTM1/RHEB/RB1/MAPK14/RBL2/MAPK13/CAPN2/TSC1/CDKN2B/HIPK4/GADD45B/CDKN1A/CHEK2/VDAC2/CCNE1/ITPR1/LIN37/PIK3R3	1.18194557404726
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	14/1146	85/9376	1.347541320193	ENTPD5/DCTPP1/GDA/NT5C2/AK7/CDA/AMPD3/PNP/ENTPD6/AK9/ASMTL/GUK1/UCK1/UPP2	1.20105448343796
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	14/1146	86/9376	1.33187223507448	ERBB3/PIK3CB/ERBB2/GAB1/CAMK2B/MAP2K7/CDKN1A/RPS6KB2/BTC/HBEGF/CAMK2G/TGFA/PIK3R3/PAK6	1.15369316117102
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	14/1146	86/9376	1.33187223507448	DSP/ITGB4/JUP/DSC2/DSG2/ITGA6/ITGA3/CTNNA1/DAG1/SGCD/ATP2A2/TCF7/ITGB6/CACNG8	1.15369316117102
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	8/1146	44/9376	1.48754561320006	B4GALNT3/HEXA/MGAT4B/MGAT1/CHST9/KRTCAP2/CHST8/ALG3	1.20957347833965
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	4/1146	18/9376	1.8181113050223	HEXA/NEU1/FUCA1/AGA	1.29638845722239
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	4/1146	18/9376	1.8181113050223	ABCD4/ZNF76/CD320/MMAB	1.29638845722239
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	6/1146	31/9376	1.58351629792265	ACSS2/AFMID/PCCA/GRHPR/GLDC/HYI	1.21428942848524
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	7/1146	38/9376	1.5071185817948	GALE/HKDC1/HEXA/UAP1/NAGK/GNE/AMDHD2	1.16883287210593
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	10/1146	59/9376	1.3866950631526	PLAAT3/MGLL/PIK3CB/ADCY9/INSR/IRS1/ABHD5/GNAS/PTGS1/PIK3R3	1.11182034040352
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	10/1146	59/9376	1.3866950631526	GADD45A/PIK3CB/ERBB2/CDH1/CTNNA1/APC/GADD45B/CDKN1A/TCF7/PIK3R3	1.11182034040352
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	4/1146	19/9376	1.72242123633692	HGSNAT/HEXA/HPSE/SGSH	1.17618874468299
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	23/1146	157/9376	1.19856382210069	FZD6/PARD6B/ID1/CDH1/PRKCI/SMAD3/RASSF6/PPP2R1B/WNT2B/YWHAH/BMP6/CTNNA1/APC/PPP2R2D/PRKCZ/SAV1/SMAD1/ID2/YWHAB/TCF7/FZD8/BMP7/BMP8B	0.936237585437729
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	5/1146	26/9376	1.57336555242314	PLAAT3/ACOX3/PLA2G6/PLA2G12A/PLB1	1.09242214441586
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	8/1146	47/9376	1.39259589320857	PIK3CB/HKDC1/INSR/IRS1/PRKCZ/MAFA/SOCS1/PIK3R3	1.00682772022779
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	12/1146	76/9376	1.29181592725269	ADCY9/GAST/CAMK2B/GNAS/KCNQ1/SLC9A4/KCNK2/ITPR1/SLC9A1/ATP1A1/CAMK2G/CFTR	0.953130447475958
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	19/1146	128/9376	1.21444153577661	ADCY9/ENTPD5/GDA/NT5C2/PDE4C/AK7/ENPP4/PDE7B/AMPD3/PNP/GUCY1B1/ENTPD6/PDE6A/NUDT9/AK9/PDE3A/GUK1/FHIT/ADPRM	0.911523799886377
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	4/1146	20/9376	1.63630017452007	DHCR24/TM7SF2/FDFT1/CYP2R1	1.06294296766399
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	4/1146	20/9376	1.63630017452007	CYB5R4/UAP1/GNE/CYB5RL	1.06294296766399
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	21/1146	144/9376	1.19313554392088	DLX5/FZD6/PIK3CB/ID1/FGFR2/REST/ID4/SMAD3/MAPK14/ID3/WNT2B/MAPK13/IL6ST/FGFR1/APC/INHBB/SMAD1/ID2/TCF7/PIK3R3/FZD8	0.871512427844939
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	11/1146	70/9376	1.2856644228372	ADIPOR1/LEPR/TRADD/IRS1/PPARGC1A/PRKAG1/SLC2A1/PRKAB1/NFKBIB/CD36/PCK1	0.895162089290733
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	10/1146	63/9376	1.29865093215879	PLAAT3/PTGR1/PLA2G6/PLA2G12A/GPX4/LTA4H/HPGD/PTGS1/ALOX5/PLB1	0.887497988236308
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/1146	14/9376	1.75317875841436	B3GNT2/CHST1/ST3GAL1	1.0523393061918
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	12/1146	78/9376	1.25869244193852	ITPK1/PIK3CB/CDIPT/MTMR7/INPP5K/FIG4/MTMR14/MTMR8/INPP5J/SYNJ2/INPP1/PLCD3	0.856079899789081
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	15/1146	101/9376	1.21507438701985	PIK3CB/DIAPH1/RAC1/SMAD3/MAPK14/MAPK13/VEGFA/PRKCZ/NOS3/VEGFB/THBD/PIK3R3/PLCD3/EDN1/VEGFC	0.81090588259849
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	5/1146	28/9376	1.46098229867863	B3GNT2/FUT2/B3GNT3/B4GALNT2/B3GALNT1	0.911553037133833
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	11/1146	72/9376	1.24995152220283	TRIM25/RIPK1/TRADD/MAPK14/MAPK13/MAP3K1/CASP8/TKFC/MAVS/FADD/NFKBIB	0.794447518273842
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	13/1146	87/9376	1.22252311889431	GADD45A/PIK3CB/RALB/RAC1/SMAD3/RALGDS/APC/GADD45B/CDKN1A/RPS6KB2/TCF7/TGFA/PIK3R3	0.778087274732354
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	8/1146	50/9376	1.30904013961606	SAT1/ARG2/MAOA/ALDH2/ALDH3A2/CNDP2/P4HA1/NOS3	0.817579921570907
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	16/1146	110/9376	1.19003649056005	ID1/ID4/SMAD3/PPP2R1B/ID3/BMP6/INHBB/SMAD1/CDKN2B/ID2/RGMB/RPS6KB2/BAMBI/TMEM53/BMP7/BMP8B	0.748109596351727
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	6/1146	36/9376	1.36358347876672	UGT2B7/CRYL1/AKR1A1/DCXR/CRPPA/FGGY	0.815567633942073
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	15/1146	103/9376	1.19148070960199	LAMA5/ARG2/ACTN4/PIK3CB/LAMC2/LAMB3/TLR4/LAMA4/LAMC1/HSPB1/GNAS/LAMA3/PIK3R3/LAMB2/LAMB4	0.729141034553688
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	3/1146	15/9376	1.63630017452007	HEXA/B3GALT4/ST3GAL1	0.92028973664475
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	34/1146	250/9376	1.11268411867365	RAB11FIP1/PARD6B/CBLC/FGFR2/CHMP4C/SH3GLB1/PRKCI/CYTH1/NEDD4L/SMAD3/ACTR3C/CYTH2/RAB11FIP4/WASHC2C/HSPA1B/ARF3/CLTA/RAB11B/WASHC3/PRKCZ/CHMP2A/ARPC1B/HSPA1A/WASHC5/SNF8/RAB22A/VPS37C/VPS25/DNAJC6/LDLRAP1/AGAP9/PLD2/HSPA6/HSPA1L	0.673861297515315
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	8/1146	51/9376	1.28337268589809	PLAAT3/PLPP2/PLA2G6/CEPT1/PLA2G12A/GDPD3/PLD2/PLB1	0.757175728016559
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	17/1146	119/9376	1.16878583894291	DAB2IP/PIK3CB/RPS6KA5/RIPK1/TRADD/MAPK14/MAPK13/CASP8/FRMD8/MAP2K7/RHBDF1/FADD/RIPK3/PIK3R3/RPS6KA4/EDN1/VEGFC	0.691436632642315
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	9/1146	59/9376	1.24802555683734	ENTPD5/DCTPP1/NT5C2/CDA/ENTPD6/AK9/ASMTL/UCK1/UPP2	0.713119678289876
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	9/1146	59/9376	1.24802555683734	MGST2/MGST1/GCLC/GPX3/MGST3/GSTO1/GPX4/GSTK1/GGT6	0.713119678289876
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	6/1146	37/9376	1.32672987123249	GADD45A/PAX8/CDH1/GADD45B/CDKN1A/TCF7	0.743049156214851
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	8/1146	52/9376	1.25869244193852	NCEH1/TSPO/NPC2/VDAC2/SORT1/LDLRAP1/CD36/LIPC	0.698011068198254
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	4/1146	23/9376	1.42286971697397	ARG2/ASL/NOS3/ACY1	0.757657741930006
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	14/1146	98/9376	1.16878583894291	LIMK2/PIK3CB/GAB2/RAC1/ACTR3C/WASF2/PLPP2/PLA2G6/ARPC1B/VAV2/RPS6KB2/SCIN/PIK3R3/PLD2	0.626758005520408
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	7/1146	45/9376	1.27267791351561	DEFB1/ABCC3/ABCD3/ABCD4/ABCB9/ABCA3/CFTR	0.684179651949619
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	22/1146	160/9376	1.12495636998255	CLDN1/F11R/CLDN4/CADM1/SDC4/CLDN7/CXADR/CLDN3/CDH1/ITGA6/CD58/SDC1/CD99/PVR/SDC3/CLDN12/ALCAM/CLDN10/CLDN16/VTCN1/CLDN8/CLDN22	0.594874274349842
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	3/1146	16/9376	1.53403141361257	MAOA/ALDH3B2/MIF	0.797750161677287
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	19/1146	137/9376	1.13466070495917	TNFSF10/DAB2IP/GADD45A/PARP4/CTSD/PIK3CB/ERN1/CTSV/RIPK1/TRADD/TUBA1C/CAPN2/CASP8/CASP6/GADD45B/ITPR1/FADD/DDIT3/PIK3R3	0.592470475570949
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	14/1146	99/9376	1.15697992137783	HRH1/PIK3CB/ADCY9/MAPK14/MAPK13/CAMK2B/PLA2G6/GNAS/IL1RAP/TRPV1/TRPM8/ITPR1/CAMK2G/PIK3R3	0.585916806646369
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	29/1146	216/9376	1.09844224678431	TNFSF10/PIK3CB/ERN1/SOD2/ERO1A/RAC1/HSPA2/MAPK14/MAPK13/HSPA1B/TLR4/CAMK2B/CASP8/XBP1/CASP6/HSPA1A/VAV2/NOS3/POU2F2/MAP2K7/ITPR1/CAMK2G/DDIT3/PIK3R3/POU2F3/CD36/LBP/HSPA6/HSPA1L	0.546183637375413
Human Diseases	Cancer: specific types	hsa05214	Glioma	11/1146	76/9376	1.18416459998163	GADD45A/PIK3CB/RB1/CAMK2B/GADD45B/CDKN1A/CAMK2G/PDGFA/TGFA/PDGFB/PIK3R3	0.601519215357034
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	10/1146	69/9376	1.18572476414498	PIK3CB/GAB2/RAC1/MAPK14/MAPK13/VAV2/MAP2K7/BTK/ALOX5/PIK3R3	0.57778669025092
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	23/1146	170/9376	1.10690894158711	MET/GADD45A/FZD6/MGST2/PIK3CB/MGST1/SMAD3/RB1/WNT2B/GAB1/APC/MGST3/GADD45B/GSTO1/KEAP1/CDKN1A/RPS6KB2/TXNRD2/TCF7/TGFA/PIK3R3/FZD8/HMOX1	0.524905392975941
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	4/1146	24/9376	1.36358347876672	B3GAT3/EXTL3/XYLT2/B4GALT7	0.665480818117164
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	8/1146	54/9376	1.2120742033482	USP1/RMI1/RPA2/CENPX/FANCF/ATRIP/CENPS/FANCD2	0.583187496656477
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	11/1146	77/9376	1.16878583894291	GADD45A/PIK3CB/BCR/RUNX1/GAB2/SMAD3/RB1/MECOM/GADD45B/CDKN1A/PIK3R3	0.554933924127815
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	16/1146	116/9376	1.12848287897936	PFKP/HKDC1/RPIA/ACOX3/ACSS2/OGDH/TKT/GAPDH/PCCA/TKFC/IDNK/FH/ACADS/ALDOA/GLDC/ENO2	0.519573257968053
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	3/1146	17/9376	1.44379427163536	ACOT8/SLC27A5/HSD3B7	0.683391320443341
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	15/1146	109/9376	1.12589461549546	PIK3CB/IFNAR1/RIPK1/RAC1/MAPK14/TLR5/MAPK13/TLR4/CASP8/TLR1/MAP2K7/FADD/SPP1/PIK3R3/LBP	0.493320147440691
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	9/1146	63/9376	1.16878583894291	ALDH2/PRDM2/DHTKD1/KMT5A/ALDH3A2/MECOM/PLOD2/EHHADH/SETMAR	0.501579189530083
NA	NA	hsa04519	Cadherin signaling	52/1146	404/9376	1.05306446875054	MET/DSP/TMC5/KRT80/JUP/ACTN4/GABRE/DSC2/FZD6/KRT7/GABRP/TJP1/ERBB2/LIMA1/TMC4/DSG2/KRT23/CDH1/MYO1E/RRAS2/KRT19/RAC1/PSENEN/CELSR2/PSEN1/MAPK14/WNT2B/ACTR3C/PCDH1/YWHAH/MAPK13/KRT18/PCDH10/FGFR1/CTNNA1/APC/PKP3/SAV1/ARPC1B/TMC1/KRT8/VAV2/KRT15/YWHAB/FMN1/CDH26/TCF7/PSEN2/FZD8/PCDHA10/AMOTL2/PCDH17	0.406843985623995
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	7/1146	48/9376	1.19313554392088	ALDH2/ACADSB/PCCA/ALDH3A2/ACADM/EHHADH/ACADS	0.500572038215093
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	8/1146	56/9376	1.16878583894291	SRD5A3/ALG6/MGAT4B/ST6GAL1/MGAT1/DPM3/KRTCAP2/ALG3	0.472715772879033
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	33/1146	254/9376	1.06295090077091	MET/ERBB3/HRH1/MCU/ERBB2/FGFR2/ADCY9/SLC25A4/TFEB/FGF18/ORAI2/VEGFA/FGFR1/CAMK2B/ATP2B4/GNAS/NOS3/FGF9/EDNRB/PHKG2/PDGFC/VDAC2/ATP2A2/VEGFB/ITPR1/CAMK2G/PHKA1/PDGFA/TGFA/PDGFB/PLCD3/CHRFAM7A/VEGFC	0.379534974416703
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	6/1146	41/9376	1.19729281062444	MAOA/ALAS1/DMGDH/GRHPR/GLDC/BPGM	0.472415410801573
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	4/1146	26/9376	1.25869244193852	HNF1B/HNF4G/FOXA2/MAFA	0.492881637155084
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	19/1146	144/9376	1.07950358735699	MCU/PIK3CB/ERN1/WIPI2/SLC25A4/ATG14/WIPI1/PSMD4/FGF14/XBP1/ADRM1/ATG13/PIK3R4/KAT5/VDAC2/ATP2A2/ITPR1/TBP/PIK3R3	0.358755115879945
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	10/1146	73/9376	1.12075354419183	MET/GADD45A/PIK3CB/ERBB2/RB1/GADD45B/CDKN1A/TGFA/FHIT/PIK3R3	0.386480721656194
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	12/1146	89/9376	1.1031237131596	TJP1/ADCY9/TUBA1C/TUBB8/GUCY1B1/TUBB4B/GNAS/PDGFC/TUBB2A/ITPR1/PDGFA/PDGFB	0.364748783531913
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	14/1146	105/9376	1.09086678301338	CITED2/GABARAPL1/FKBP8/PINK1/TFEB/RRAS2/SQSTM1/BNIP3/MAP1LC3B/BCL2L13/MON1B/MAP1LC3A/SAMM50/ATG9B	0.349393274744091
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	3/1146	19/9376	1.29181592725269	OGDH/DHTKD1/GLDC	0.475111461138951
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	13/1146	98/9376	1.08530113616127	ITPK1/PIK3CB/DGKH/CDIPT/MTMR7/MTMR14/MTMR8/DGKE/ITPR1/SYNJ2/INPP1/PIK3R3/PLCD3	0.31675151365718
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	14/1146	106/9376	1.08057558694722	SPINT1/PIK3CB/ERBB2/FGFR2/RB1/FGFR1/CDKN1A/PDGFC/CCNE1/TCF7/PDGFA/TGFA/PDGFB/PIK3R3	0.311311076160005
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	5/1146	35/9376	1.16878583894291	PFKP/HKDC1/PFKFB3/TKFC/ALDOA	0.373294311784989
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	18/1146	139/9376	1.05947493314249	CTSD/PIK3CB/ADCY9/KRT23/KRT19/ESR2/KRT18/HSPA1B/HSPA1A/GNAS/NOS3/KRT15/ITPR1/HBEGF/TGFA/PIK3R3/HSPA6/HSPA1L	0.26360516790816
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	15/1146	115/9376	1.06715228773048	SGK1/SLC34A2/ADCY9/PDE4C/FGFR1/GNAS/CDKN1A/WNK3/ITPR1/HBEGF/MMP15/SLC12A3/MAFB/VDR/PLD2	0.270370198693785
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	10/1146	75/9376	1.09086678301338	MGST2/PIK3CB/ERBB2/MGST1/CASP8/MGST3/GSTO1/CDKN1A/FADD/PIK3R3	0.294814603149288
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	10/1146	75/9376	1.09086678301338	PERP/GADD45A/CCNG2/PPP1R13L/CASP8/GADD45B/CDKN1A/CHEK2/CCNE1/STEAP3	0.294814603149288
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	13/1146	99/9376	1.07433849842227	NOTCH2/PIK3CB/ERBB2/ADCY9/RB1/MAPK14/ESR2/MAPK13/GNAS/CDKN1A/RPS6KB2/HBEGF/PIK3R3	0.277463354702722
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/1146	12/9376	1.36358347876672	NECTIN4/CD46	0.470264386561496
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	19/1146	148/9376	1.05032781472572	GADD45A/NOTCH2/FZD6/PIK3CB/ERBB2/FGF18/RB1/WNT2B/ESR2/FGFR1/APC/GADD45B/FGF9/CDKN1A/RPS6KB2/TCF7/HEY2/PIK3R3/FZD8	0.230283683490158
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	4/1146	28/9376	1.16878583894291	MOCOS/PCBD2/FPGS/GCH1	0.333759549020879
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	8/1146	60/9376	1.09086678301338	PIK3CB/RAC1/MAPK14/MAPK13/VEGFA/HSPB1/NOS3/PIK3R3	0.263477823680631
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	7/1146	52/9376	1.1013558866962	ADCY9/INSR/BMP6/HSD17B2/GNAS/ALOX5/ACOT4	0.273481243637614
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	12/1146	93/9376	1.05567753194843	ADCY9/MAPK14/MAPK13/MAP3K1/CAMK2B/GNAS/MAP3K4/MAP2K7/ITPR1/HBEGF/CAMK2G/PLD2	0.201351701657368
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	18/1146	142/9376	1.03709165990709	FOSL2/BLNK/PIK3CB/IFNAR1/GAB2/RAC1/SQSTM1/MAPK14/MAPK13/MAP2K7/TNFRSF11A/ATP2A2/SIRPA/BTK/ITPR1/SOCS1/PIK3R3/TNFRSF11B	0.166189482542107
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	5/1146	37/9376	1.10560822602707	GALE/HKDC1/UAP1/NAGK/GNE	0.240174254477415
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	3/1146	21/9376	1.16878583894291	B3GAT3/XYLT2/B4GALT7	0.288936087418245
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	3/1146	21/9376	1.16878583894291	ALDH2/VNN1/ALDH3A2	0.288936087418245
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	9/1146	70/9376	1.05190725504862	MGST2/EPHX1/UGT2B7/MGST1/MGST3/GSTO1/CYP2C18/GSTK1/HSD11B1L	0.16265731104061
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	21/1146	168/9376	1.02268760907504	TNFSF10/PYGB/IFNAR1/STAT6/PYGL/CHMP4C/SLC25A4/RIPK1/TRADD/SQSTM1/FTH1/CAPN2/TLR4/CAMK2B/CASP8/CHMP2A/PPIA/VDAC2/FADD/CAMK2G/RIPK3	0.110723229703161
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	4/1146	30/9376	1.09086678301338	PLAAT3/PLA2G6/PLA2G12A/PLB1	0.186007699390092
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	8/1146	63/9376	1.03892074572703	GADD45A/FZD6/WNT2B/APC/GADD45B/CDKN1A/TCF7/FZD8	0.115660390823858
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	19/1146	154/9376	1.00940595181433	RPS6KA5/ADCY9/PPP2R1B/MAPK14/MAPK13/PPP2R3A/PPP2R5A/CAMK2B/PPP2R2D/ATP2B4/GNAS/ATP2A2/KCNQ1/KCNK2/SLC9A1/ATP1A1/CAMK2G/POPDC3/CACNG8	0.0439165869112451
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	24/1146	196/9376	1.00181643337963	PIK3CB/IFNAR1/C3/RAC1/TRADD/ATG14/RB1/MAPK14/MAPK13/MAP1LC3B/IL6ST/VEGFA/GNG7/CASP8/MAP1LC3A/MAP2K7/CDKN1A/ITPR1/TCF7/FADD/PDGFB/PIK3R3/MICA/RCAN1	0.00958968183798977
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	19/1146	155/9376	1.00289365535101	AHR/FZD6/ADCY9/NCEH1/RB1/WNT2B/ARNT/APC/CAMK2B/CDKN2B/GNAS/CDKN1A/FH/KCNK2/CCNE1/ITPR1/TCF7/CAMK2G/FZD8	0.013555067066292
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	4/1146	31/9376	1.05567753194843	ALDH2/UGT2B7/ALDH3A2/AKR1A1	0.115864181840029
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	25/1146	205/9376	0.997744008853701	GADD45A/BLNK/PIK3CB/IFNAR1/TAPBPL/RIPK1/RAC1/TRADD/RB1/MAPK14/CD58/PSMD4/MAPK13/CD44/CASP8/ADRM1/GADD45B/MAVS/MAP2K7/CDKN1A/BTK/CCNE1/FADD/NFKBIB/PIK3R3	-0.0121866406202315
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	3/1146	23/9376	1.06715228773048	LARGE2/CRPPA/POMT2	0.120317082649929
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	3/1146	23/9376	1.06715228773048	RFC3/RFC5/RPA2	0.120317082649929
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	3/1146	23/9376	1.06715228773048	ACE/NLN/ACE2	0.120317082649929
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3/1146	23/9376	1.06715228773048	SLC25A10/ATP1A1/PCK1	0.120317082649929
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	17/1146	140/9376	0.993467963101471	ADCY9/HDAC5/CDH1/RRAS2/SMAD3/MAP1LC3B/GNG7/PPARGC1A/MAP1LC3A/PIK3R4/NOS3/PRKAG1/RPS6KB2/PRKAB1/ITPR1/SLC9A1/SPP1	-0.0290568622452004
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	10/1146	82/9376	0.997744008853701	TAPBPL/LGMN/HSPA2/HSPA1B/HSPA1A/PSME3/RFXANK/IFI30/HSPA6/HSPA1L	-0.00765633649621498
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	12/1146	99/9376	0.991697075466709	ACE/ITGB4/ITGA6/ITGA3/DAG1/SGCD/PRKAG1/PRKAB1/ATP2A2/ITGB6/EDN1/CACNG8	-0.0309900972409251
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	6/1146	49/9376	1.00181643337963	GALNT1/ST6GAL1/GALNT15/C1GALT1C1/EOGT/POMT2	0.00475690584250976
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	26/1146	217/9376	0.980271993952116	KLF5/BCL6/AHR/NOTCH2/MGST2/PIK3CB/EPHX1/UGT2B7/ADCY9/MGST1/RPS6KA2/FGF18/RB1/ESR2/VEGFA/ARNT/GNAS/MGST3/GSTO1/FGF9/RPS6KB2/PAQR7/PIK3R3/RPS6KA6/VDR/CHRFAM7A	-0.109715265706729
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	9/1146	75/9376	0.981780104712042	ARG2/PFKP/ASL/RPIA/TKT/GAPDH/ALDOA/ACY1/ENO2	-0.0591139140245565
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	9/1146	76/9376	0.968861945439515	ACOX3/SCD/SLC27A4/ACADM/EHHADH/CPT2/SLC27A5/CD36/PCK1	-0.101703248880815
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	8/1146	68/9376	0.96252951442357	RDH13/UGT2B7/RDH10/CYP2C18/BCO1/RETSAT/DHRS3/DHRS4L2	-0.115716055089563
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	12/1146	102/9376	0.96252951442357	ADCY9/RAC1/ATP2B4/GNAS/PLA2G12A/BST1/ATP2A2/KCNQ1/ITPR1/SLC9A1/ATP1A1/CFTR	-0.141982196528513
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	22/1146	187/9376	0.96252951442357	CASP4/MCU/GBP2/GABARAPL1/IFNAR1/RIPK1/MAPK14/MAPK13/MAP1LC3B/TLR4/CASP8/GBP3/TRIP6/MAP1LC3A/CARD6/MAVS/VDAC2/ITPR1/FADD/NFKBIB/RIPK3/NAMPT	-0.193131906667396
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	4/1146	34/9376	0.96252951442357	NPAS2/RORC/PRKAG1/PRKAB1	-0.0816745739275213
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	12/1146	103/9376	0.953184567681594	ACE/PIK3CB/C3/PPP2R1B/MAPK14/MAPK13/TLR4/PPP2R2D/CASP8/GNAS/FADD/PIK3R3	-0.178268885804074
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	5/1146	43/9376	0.951337310767482	AGPAT2/PLPP2/SLC27A4/PLA2G12A/CD36	-0.119343214083387
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	19/1146	163/9376	0.953671880855255	PIK3CB/IFNAR1/STAT6/SMAD3/RB1/MAPK14/MAPK13/MAP3K1/TLR4/CASP8/SLC10A1/MAVS/MAP2K7/CDKN1A/YWHAB/CCNE1/FADD/PIK3R3/HSPG2	-0.222646547390507
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	16/1146	138/9376	0.948579811315983	ADCY9/RPS6KA2/CPEB4/PPP2R1B/MAPK14/YWHAH/MAPK13/PPP2R5A/CAMK2B/YWHAB/CCNE1/ITPR1/CDC23/ANAPC11/CAMK2G/RPS6KA6	-0.227071306930968
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	3/1146	26/9376	0.944019331453886	ABCD4/SLC52A3/PLB1	-0.106658870105693
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	15/1146	130/9376	0.944019331453886	PIK3CB/ADCY9/MAPK14/MAPK13/VEGFA/GNG7/PRKCZ/GNAS/NOS3/MAP2K7/EDNRB/VEGFB/PIK3R3/EDN1/VEGFC	-0.239834050225053
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	9/1146	79/9376	0.932069719663331	MGST2/EPHX1/UGT2B7/MGST1/ALDH3B2/MGST3/GSTO1/GSTK1/HSD11B1L	-0.22624738404195
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	6/1146	53/9376	0.926207645954757	ADCY9/CLTA/ATP2B4/GNAS/ATP1A1/VDR	-0.201024729808669
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	12/1146	105/9376	0.935028671154326	TRIM25/GADD45A/BLNK/RIPK1/LTBR/TRADD/PPP1R13L/TLR4/GADD45B/TNFRSF11A/BTK/LBP	-0.24982226284519
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	10/1146	88/9376	0.92971600825004	CD55/CD59/C3/C4BPA/CLU/CD46/KLKB1/SERPINA1/THBD/FGB	-0.247180770244706
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	7/1146	62/9376	0.923717840454878	NOTCH2/PSENEN/PSEN1/NRARP/HEY2/TLE2/PSEN2	-0.224868558952159
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	4/1146	36/9376	0.90905565251115	RFC3/RFC5/RNASEH1/RPA2	-0.20400065083671
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	4/1146	37/9376	0.884486580821659	RIMKLB/ASL/NIT2/ASRGL1	-0.262700647260022
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	4/1146	37/9376	0.884486580821659	MAOA/ALDH3B2/FAHD1/MIF	-0.262700647260022
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	8/1146	73/9376	0.896602835353463	MAOA/MGST2/UGT2B7/MGST1/ALDH3B2/MGST3/GSTO1/GSTK1	-0.330930334817469
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	9/1146	82/9376	0.897969607968331	MGST2/UGT2B7/MGST1/CDA/MGST3/GSTO1/CES2/UCK1/UPP2	-0.34626865247975
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	11/1146	100/9376	0.899965095986038	CD55/CD24/IL6R/CSF2RA/CD59/CD9/ITGA6/ITGA3/IL4R/CD44/CD36	-0.375274641878448
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	12/1146	109/9376	0.900715692396369	IL6R/AHR/STAT6/RUNX1/RORC/SMAD3/MAPK14/MAPK13/IL4R/IL6ST/IL1RAP/NFKBIB	-0.389047212804239
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	9/1146	83/9376	0.887150697028953	RIPK1/POLR3K/DNASE2/CASP8/MAVS/FADD/POLR3F/NFKBIB/RIPK3	-0.385334583134793
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	23/1146	205/9376	0.917924488145405	ACTN4/PIK3CB/C3/HDAC5/LTBR/RAC1/TRADD/RB1/HDAC7/RBL2/YWHAH/IL6ST/CASP8/CDKN2B/CDKN1A/YWHAB/CCNE1/TBP/HPN/HDAC11/SCIN/HDAC10/PIK3R3	-0.443363781960957
Human Diseases	Infectious disease: viral	hsa05162	Measles	15/1146	136/9376	0.902371419772097	PIK3CB/IFNAR1/TRADD/HSPA1B/TLR4/CASP8/CD46/HSPA1A/MAVS/CCNE1/FADD/NFKBIB/PIK3R3/HSPA6/HSPA1L	-0.427945507490158
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/1146	29/9376	0.846362159234519	CNGA1/PDE6A/SLC24A1	-0.309199727110149
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	5/1146	48/9376	0.852239674229203	SLC5A1/PIK3CB/HKDC1/ATP1A1/PIK3R3	-0.382967764176607
Organismal Systems	Digestive system	hsa04970	Salivary secretion	10/1146	93/9376	0.879731276623694	ADCY9/VAMP2/ATP2B4/CST1/GUCY1B1/GNAS/BST1/ITPR1/SLC9A1/ATP1A1	-0.434938677425707
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	25/1146	224/9376	0.913113936674146	PIK3CB/ADCY9/SLC25A4/ETS2/LTBR/SMAD3/TLN1/RB1/ELK4/MAP3K1/TSPO/CDKN2B/SLC2A1/CDKN1A/CHEK2/KAT5/VDAC2/MSX1/CCNE1/TLN2/TBP/CDC23/ANAPC11/MSX2/PIK3R3	-0.491127387793113
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	4/1146	39/9376	0.839128294625677	MTHFS/MTHFD1L/DMGDH/GLDC	-0.375652530958545
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	17/1146	155/9376	0.897325902156167	ATP6V1A/C3/RAC1/TUBA1C/STX7/ATP6V0E1/ATP6V1C2/TUBB8/TLR4/ATP6V1D/TUBB4B/ATP6V0C/TUBB2A/RILP/ATP6V1F/PLA2R1/CD36	-0.480967535321079
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	10/1146	94/9376	0.870372433255356	MAPK6/IL17RA/TRADD/MAPK14/USP25/MAPK13/CASP8/FADD/LCN2/IL17RB	-0.471322902054735
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	3/1146	30/9376	0.818150087260035	OGDH/FH/PCK1	-0.372253564848545
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	11/1146	103/9376	0.873752520374794	SLC1A1/SLC15A1/SLC38A2/COL14A1/COL17A1/COL28A1/KCNQ1/ATP1A1/KCNK5/COL9A2/ACE2	-0.480738859256662
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	9/1146	86/9376	0.856203579690734	ADCY9/CAMK2B/VAMP2/GNAS/SLC2A1/ATP1A1/CAMK2G/STX1A/KCNMB3	-0.499881970163744
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	10/1146	95/9376	0.861210618168458	ATP6V1A/ATP6V0E1/ATP6V1C2/VEGFA/TLR4/ATP6V1D/ATP6V0C/TNFRSF11A/ATP6V1F/TNFSF13	-0.507339512358069
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	13/1146	122/9376	0.871799273309873	PIK3CB/PPP2R1B/MAPK14/PTPN6/MAPK13/PPP2R3A/PPP2R5A/PPP2R2D/VAV2/MAP2K7/NFKBIB/PIK3R3/PAK6	-0.531843289710455
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	3/1146	31/9376	0.791758148961324	BAG6/GET3/UBL4A	-0.433348441482575
NA	NA	hsa04981	Folate transport and metabolism	3/1146	31/9376	0.791758148961324	ABCC3/MTHFS/FPGS	-0.433348441482575
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	17/1146	158/9376	0.880288068570924	GADD45A/SMAD3/PPP2R1B/RB1/RBL2/YWHAH/PPP2R5A/CDKN2B/GADD45B/CDKN1A/CHEK2/YWHAB/CCNE1/DBF4B/CDC23/ANAPC11/MAD2L1BP	-0.566272744263776
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	15/1146	142/9376	0.864243049922572	CBLC/HERC2/NEDD4L/MAP3K1/UBE3B/KEAP1/CDC34/UBE2S/UBE2D4/CDC23/ANAPC11/DET1/UBE2Q1/SOCS1/ERCC8	-0.608260114035826
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	3/1146	32/9376	0.767015706806283	PFKP/GALE/HKDC1	-0.492621369701857
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	12/1146	116/9376	0.846362159234519	SLC1A1/SLC38A1/SHANK2/ADCY9/HOMER2/SLC38A2/GNG7/GNAS/SLC1A3/ITPR1/DLGAP1/PLD2	-0.621297671003484
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	9/1146	89/9376	0.827342784869698	HAP1/GABRE/GABRP/GABARAPL1/SLC38A1/ADCY9/SLC38A2/GNG7/SLC6A12	-0.610688921657824
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	7/1146	71/9376	0.806626846594401	PIK3CB/MAPK14/ESR2/MAPK13/TNFRSF11A/SOCS1/PIK3R3	-0.610302564002902
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	3/1146	33/9376	0.743772806600032	OGDH/DHTKD1/ACY1	-0.550195513243573
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	4/1146	44/9376	0.743772806600032	ADCY9/RAB11B/VAMP2/GNAS	-0.635685378300857
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	11/1146	110/9376	0.818150087260035	PIK3CB/ADCY9/RPS6KA2/CPEB4/MAPK14/MAPK13/KIF22/CDC23/ANAPC11/PIK3R3/RPS6KA6	-0.715881799414217
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	10/1146	101/9376	0.810049591346569	FZD6/ADCY9/WNT2B/CAMK2B/GNAS/EDNRB/TCF7/CAMK2G/FZD8/EDN1	-0.716179671198297
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	14/1146	138/9376	0.830007334901485	PIK3CB/RPS6KA2/RAC1/MAPK14/ACTR3C/ARHGEF28/WASF2/MAPK13/TLR4/ARPC1B/VAV2/MAP2K7/PIK3R3/RPS6KA6	-0.750686794826874
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/1146	13/9376	0.629346220969258	POLM	-0.499011582656413
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	10/1146	103/9376	0.794320473067995	WDR82/PPP2R1B/PPP2R3A/PPP2R5A/UPF3B/PPP2R2D/EIF4A3/CPSF3/CSTF1/CPSF4L	-0.783208832709249
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	7/1146	75/9376	0.763606748109366	ADCY9/PAX8/GPX3/GNAS/TTF1/ITPR1/ATP1A1	-0.766970948372246
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	12/1146	122/9376	0.804737790747575	PFKP/THRB/NOTCH2/PIK3CB/RHEB/SLC2A1/ATP2A2/SLC9A1/ATP1A1/PIK3R3/PLCD3/RCAN1	-0.810049197115343
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	17/1146	168/9376	0.827889969251226	IL6R/PIK3CB/IFNAR1/CSF2RA/STAT6/CLCF1/LEPR/PTPN6/IL4R/IL6ST/IL10RB/CDKN1A/PDGFA/SOCS1/IFNLR1/PDGFB/PIK3R3	-0.83995534327929
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	6/1146	66/9376	0.743772806600032	SRD5A3/UGT2B7/HSD11B2/HSD17B2/HSD11B1L/STS	-0.77947174342412
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	6/1146	66/9376	0.743772806600032	STAT6/RORC/SMAD3/TLR5/IL4R/TLR4	-0.77947174342412
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	3/1146	36/9376	0.681791739383362	PYGB/HKDC1/PYGL	-0.713784793226102
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	10/1146	105/9376	0.779190559295271	ITGB4/ADCY9/ITGA6/ITGA3/DAG1/SGCD/GNAS/ATP2A2/ITGB6/CACNG8	-0.849037800434471
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/1146	37/9376	0.663364935616245	APOL1/LAMA4/IDO2	-0.765575548997458
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	9/1146	97/9376	0.759108328385599	RPS6KA5/ADCY9/NOS1AP/GNG7/CAMK2B/GUCY1B1/GNAS/ITPR1/CAMK2G	-0.88988747563088
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	6/1146	68/9376	0.721897135817678	JUP/PIK3CB/RUNX1/RPS6KB2/TCF7/PIK3R3	-0.8588350499661
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	7/1146	78/9376	0.734237257797467	PFKP/TOB1/MPHOSPH6/CNOT10/EXOSC10/PNLDC1/ENO2	-0.879477343858736
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	18/1146	181/9376	0.813629921032079	CTSD/KSR1/C3/TRADD/MAPK14/MAPK13/IL10RB/TLR4/CAMK2B/CASP8/RFXANK/ATP6V0C/TLR1/FADD/CAMK2G/PLA2R1/VDR/LBP	-0.944751606939413
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/1146	15/9376	0.54543339150669	AK7	-0.65744596838015
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/1146	27/9376	0.6060371016741	EHHADH/ACADS	-0.764949306835249
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	3/1146	38/9376	0.645907963626343	BLNK/RFXANK/BTK	-0.816129455165436
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	9/1146	98/9376	0.751362325034726	ADCY9/CAMK2B/DAGLB/ATP2B4/GNAS/PRKD1/ITPR1/ATP1A1/CAMK2G	-0.923274453795732
Organismal Systems	Endocrine system	hsa04924	Renin secretion	6/1146	69/9376	0.711434858486987	ACE/GUCY1B1/GNAS/ITPR1/PDE3A/EDN1	-0.89772141482674
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	17/1146	173/9376	0.80396251349252	TNFSF10/TRIM25/PIK3CB/IFNAR1/TMPRSS4/SLC25A4/TRADD/RAB11B/NUP98/TLR4/CASP8/DNAJB1/MAVS/FADD/NFKBIB/PIK3R3/CPSF4L	-0.971125807407537
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	10/1146	108/9376	0.757546377092625	NUP210L/NUP98/UPF3B/SENP2/RANGAP1/NUP88/EIF4A3/PHAX/NUP93/THOC5	-0.945639430167367
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	6/1146	70/9376	0.701271503365744	CD55/CXADR/RAC1/CASP8/DAG1/SGCD	-0.936099856334575
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	8/1146	90/9376	0.72724452200892	PIK3CB/MAPK14/PTPN6/MAPK13/TLR4/RPS6KB2/NFKBIB/PIK3R3	-0.970193646268584
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	4/1146	50/9376	0.654520069808028	MET/SDC1/TLR4/CD36	-0.913983065700117
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	8/1146	91/9376	0.719252823964866	BLNK/PIK3CB/RAC1/PTPN6/VAV2/BTK/NFKBIB/PIK3R3	-1.00420682346926
Human Diseases	Substance dependence	hsa05032	Morphine addiction	8/1146	91/9376	0.719252823964866	GABRE/GABRP/ADCY9/PDE4C/GNG7/PDE7B/GNAS/PDE3A	-1.00420682346926
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/1146	29/9376	0.564241439489679	RASSF6/SAV1	-0.876974235802817
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	17/1146	178/9376	0.781379296821382	FZD6/RAC1/SMAD3/CELSR2/PSEN1/WNT2B/APC/CAMK2B/SENP2/BAMBI/GPC4/RNF43/TCF7/TLE2/CAMK2G/FZD8/PORCN	-1.09883533072272
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/1146	17/9376	0.481264757211785	GGT6	-0.798791659079389
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	3/1146	41/9376	0.598646405312221	RBBP8/BABAM2/RPA2	-0.961036657701842
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	3/1146	41/9376	0.598646405312221	GABRE/GABRP/CHRFAM7A	-0.961036657701842
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/1146	30/9376	0.54543339150669	ABCC3/FPGS	-0.930514829087181
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	5/1146	63/9376	0.649325466079393	ERCC5/RFC3/RFC5/RPA2/ERCC8	-1.04209600529482
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	22/1146	226/9376	0.79642928848322	PIK3CB/ADCY9/ACOX3/RRAS2/RAC1/PDE4C/CAMK2B/ATP2B4/GNAS/VAV2/CNGA1/ATP2A2/KCNK2/SLC9A1/ATP1A1/PDE3A/CAMK2G/POPDC3/CFTR/PIK3R3/PLD2/EDN1	-1.15594453617044
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	12/1146	133/9376	0.738180529858678	MAOA/PPP2R1B/MAPK14/MAPK13/PPP2R3A/GNG7/PPP2R5A/CAMK2B/PPP2R2D/GNAS/ITPR1/CAMK2G	-1.13474770481292
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	22/1146	227/9376	0.792920789415012	IL6R/PIK3CB/ADCY9/TAPBPL/RIPK1/RAC1/TRADD/RHEB/RB1/MAPK14/MAPK13/VEGFA/GNG7/IL10RB/TSC1/CASP8/GNAS/CDKN1A/RPS6KB2/ITPR1/FADD/PIK3R3	-1.17853000752164
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/1146	18/9376	0.454527826255575	MECR	-0.864361396104902
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	12/1146	134/9376	0.73267171993436	MYH14/ADCY9/PLA2G6/GUCY1B1/GNAS/PLA2G12A/ADM/ITPR1/MYL6B/ACTG2/KCNMB3/EDN1	-1.16303383854124
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	19/1146	201/9376	0.773375704375157	MET/BCL6/JUP/GADD45A/SPINT1/RUNX1/KLF3/PAX8/NUPR1/NFKBIZ/ELK4/SMAD1/GADD45B/ID2/CDKN1A/PDGFA/DDIT3/BAIAP3/HPGD	-1.21193544953412
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	14/1146	154/9376	0.743772806600032	ADCY9/CAMK2B/EEF2K/GUCY1B1/GNAS/NOS3/PRKAG1/CDKN1A/PRKAB1/ITPR1/MYL6B/CAMK2G/CACNG8/RCAN1	-1.19633015670272
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	5/1146	65/9376	0.629346220969258	ADCY9/NCEH1/GNAS/KCNK2/ITPR1	-1.11893530425422
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	5/1146	65/9376	0.629346220969258	PIK3CB/ESR2/ITPR1/SPP1/PIK3R3	-1.11893530425422
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/1146	32/9376	0.511343804537522	CASP8/FADD	-1.03321335967431
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	15/1146	166/9376	0.739292247524128	ADCY9/SLC25A4/INSR/IRS1/ATP2B4/GUCY1B1/NOS3/CNGA1/EDNRB/VDAC2/ATP2A2/ITPR1/ATP1A1/PDE3A/KCNMB3	-1.26460881277622
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	5/1146	67/9376	0.610559766611966	RPS6KA2/CAMK2B/ITPR1/CAMK2G/RPS6KA6	-1.19372621793606
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	6/1146	78/9376	0.629346220969258	C3/MAPK14/PTPN6/MAPK13/TLR4/NFKBIB	-1.2265887925883
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	3/1146	46/9376	0.53357614386524	PSMD4/ADRM1/PSME3	-1.18330548744777
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	2/1146	34/9376	0.481264757211785	POLR3K/POLR3F	-1.13068937549525
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	8/1146	100/9376	0.654520069808028	TNFSF10/IL6R/CXCL14/LTBR/IL6ST/IL10RB/CCL28/TNFRSF10D	-1.29604619864371
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	5/1146	69/9376	0.592862382072489	MAOA/CAMK2B/GNAS/CAMK2G/STX1A	-1.26659844109615
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	10/1146	122/9376	0.670614825622979	PIK3CB/ADCY9/MAPK14/MAPK13/MAP3K1/IRS1/GNAS/ITPR1/SOCS1/PIK3R3	-1.36646101192512
Organismal Systems	Nervous system	hsa04730	Long-term depression	4/1146	60/9376	0.54543339150669	PPP2R1B/GUCY1B1/GNAS/ITPR1	-1.3180638375419
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	3/1146	49/9376	0.500908216689817	MAOA/GNAS/CDK5	-1.30702983472728
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	9/1146	115/9376	0.640291372638288	PIK3CB/ADCY9/GNG7/CAMK2B/KCNQ1/ITPR1/CAMK2G/PIK3R3/CHRFAM7A	-1.44826775585057
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	8/1146	105/9376	0.623352447436217	PIK3CB/KSR1/RRAS2/MAPK14/MAPK13/CASP8/ITPR1/PIK3R3	-1.44825333802375
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	5/1146	73/9376	0.560376772095914	BICD1/PPIA/FURIN/NELFB/MAP1S	-1.40704691952796
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	3/1146	50/9376	0.490890052356021	LTBR/CCL28/TNFSF13	-1.34687381251787
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	9/1146	117/9376	0.629346220969258	BRD8/INO80D/MEAF6/YEATS4/BCL7A/CDK2AP2/RUVBL2/MCRS1/KAT5	-1.50541885304242
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	15/1146	180/9376	0.681791739383362	PIK3CB/IFNAR1/C3/TAPBPL/SRPK1/TRADD/RHEB/PILRB/TSC1/CASP8/POU2F2/MAVS/FADD/PIK3R3/POU2F3	-1.60851920410366
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	5/1146	78/9376	0.524455184141048	C3/C4BPA/MAPK14/MAPK13/TLR4	-1.57370024131786
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	10/1146	133/9376	0.615150441548898	TNFSF10/PIK3CB/IFNAR1/RAC1/PTPN6/SH3BP2/VAV2/SH2D1B/PIK3R3/MICA	-1.66797050240355
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	18/1146	214/9376	0.68816362479816	LIMK2/PIK3CB/TAPBPL/RIPK1/RAC1/TRADD/MAPK14/AP1M2/MAPK13/GNG7/TLR4/CASP8/MAP2K7/RPS6KB2/ITPR1/FADD/PIK3R3/PAK6	-1.72193417661799
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	3/1146	56/9376	0.43829468960359	CSNK1G1/IQCE/CDON	-1.57315899009817
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	2/1146	44/9376	0.371886403300016	TAF1/TBP	-1.55831480662111
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	6/1146	93/9376	0.527838765974216	NOTCH2/STAT6/MAPK14/MAPK13/IL4R/NFKBIB	-1.70751943559186
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	26/1146	298/9376	0.713822223783923	TNFSF10/IL6R/CXCL14/IFNAR1/CSF2RA/CLCF1/LTBR/IL17RA/LEPR/IL4R/IL6ST/BMP6/IL10RB/INHBB/IL1RAP/CCL28/TNFRSF11A/GDF15/TNFRSF10D/IFNLR1/BMP7/TNFSF13/TNFRSF11B/BMP8B/IL1RL2/IL17RB	-1.87338473384038
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	15/1146	195/9376	0.629346220969258	CASP4/PIK3CB/C3/SLC25A4/HDAC5/RAC1/MAPK14/HDAC7/MAPK13/TLR4/VDAC2/HDAC11/HDAC10/PIK3R3/FGB	-1.95172566800983
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	6/1146	99/9376	0.495848537733354	DEFB1/C3/KRT23/KRT19/KRT18/KRT15	-1.88171080890281
Genetic Information Processing	Translation	hsa03010	Ribosome	17/1146	222/9376	0.626511328082009	MRPL41/MRPL15/MRPS18C/MRPL37/MRPS18A/MRPS15/MRPL48/MRPL2/MRPL52/MRPL13/MRPL46/MRPS7/MRPS2/MRPL21/MRPL40/MRPS33/RPS10	-2.10148597816914
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	7/1146	115/9376	0.498004400940891	MAOA/GNG7/GNAS/CYP2C18/ITPR1/PTGS1/ALOX5	-2.02114707403202
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	12/1146	183/9376	0.536491860498384	RPP38/GNL2/EFL1/EIF6/NAT10/RMRP/SBDS/UTP14A/RPP30/TCOF1/UTP15/RPP25L	-2.36282909116489
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	1/1146	44/9376	0.185943201650008	ICA1	-2.01962952078124
Genetic Information Processing	Transcription	hsa03040	Spliceosome	17/1146	243/9376	0.572368373803317	SYF2/DDX46/CCDC12/HSPA1B/XAB2/HSPA1A/PRPF3/EIF4A3/SNRNP27/CDC5L/PHF5A/DHX16/THOC5/GPKOW/BUD13/HSPA6/HSPA1L	-2.52025365974254
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	16/1146	238/9376	0.550016865384897	ACE/IL6R/PIK3CB/IFNAR1/C3/MAPK14/MAPK13/IL6ST/TLR4/MAVS/HBEGF/NFKBIB/PIK3R3/FGB/RPS10/ACE2	-2.62383890803412
NA	NA	hsa04081	Hormone signaling	14/1146	219/9376	0.523018320622853	THRB/SLC40A1/PIK3CB/ADCY9/INSR/GAST/ADIPOR1/LEPR/ESR2/GNG7/IRS1/SMAD1/GNAS/PIK3R3	-2.66517160783816
NA	NA	hsa04082	Neuroactive ligand signaling	12/1146	199/9376	0.493356836538714	HRH1/SLC1A1/GABRE/GABRP/ADCY9/GNG7/GNAS/SLC1A3/SLC6A9/TAC4/SLC6A12/CHRFAM7A	-2.69560583946485
Organismal Systems	Sensory system	hsa04742	Taste transduction	3/1146	86/9376	0.285401193230245	SCNN1A/KCNK5/TAS2R4	-2.48417212776546
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	22/1146	323/9376	0.55725392940312	MET/ERBB3/EFNA1/NOTCH2/PIK3CB/RPS6KA5/FOXP1/ERBB2/HDAC5/VEGFA/IRS1/CD44/APC/CDKN1A/CCNE1/BMF/PDGFA/SOCS1/PDGFB/EFNA2/PIK3R3/HMOX1	-3.02160538548431
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	10/1146	193/9376	0.423911962310899	CXCL14/PIK3CB/ADCY9/RAC1/GNG7/PRKCZ/CCL28/VAV2/NFKBIB/PIK3R3	-3.01754148222543
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	2/1146	83/9376	0.197144599339767	SCMH1/UBE2D4	-2.74142544956881
Human Diseases	Substance dependence	hsa05034	Alcoholism	8/1146	191/9376	0.342680664820957	MAOA/HDAC5/HDAC7/GNG7/SLC29A1/GNAS/HDAC11/HDAC10	-3.42477102114387
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	20/1146	370/9376	0.44224329041083	HRH1/THRB/GABRE/GABRP/C3/GAL/LEPR/PYY/TSPO/ADM/EDNRB/TRPV1/GALP/LTB4R/LPAR2/TAC4/NMU/CHRFAM7A/EDN1/LYPD6B	-4.08467703346286
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	2/1146	143/9376	0.114426585630774	ACTN4/C3	-3.98198115672732
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	4/1146	449/9376	0.07288642202762	NCALD/GNG7/CAMK2B/CAMK2G	-7.51244618668477