ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0015453 oxidoreduction-driven active transmembrane transporter activity 28/2571 68/18639 0.411764705882353 2.98517399958817 2.53872302391361e-08 2.25525977745264e-05 GO:0015078 proton transmembrane transporter activity 54/2571 185/18639 0.291891891891892 2.11613106688953 3.52384340226975e-08 2.25525977745264e-05 GO:0022804 active transmembrane transporter activity 99/2571 457/18639 0.216630196936543 1.5705057334501 2.28846773220075e-06 0.000976412899072322 GO:0022853 active monoatomic ion transmembrane transporter activity 35/2571 118/18639 0.296610169491525 2.15033720309317 5.74833384322881e-06 0.00183946682983322 GO:0015399 primary active transmembrane transporter activity 44/2571 166/18639 0.265060240963855 1.92160942486398 1.0313951063257e-05 0.00264037147219379 GO:0009055 electron transfer activity 33/2571 116/18639 0.28448275862069 2.06241701203074 2.7265570287387e-05 0.00581665499464255 GO:0008137 NADH dehydrogenase (ubiquinone) activity 16/2571 41/18639 0.390243902439024 2.82915445257136 5.49076752749166e-05 0.0099095682580038 GO:0045296 cadherin binding 72/2571 334/18639 0.215568862275449 1.56281136676472 6.19348016125237e-05 0.0099095682580038 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 8/2571 13/18639 0.615384615384615 4.46135894443946 8.72483514265908e-05 0.0120720916965259 GO:0005085 guanyl-nucleotide exchange factor activity 53/2571 230/18639 0.230434782608696 1.67058495256456 9.43132163791086e-05 0.0120720916965259 GO:0003954 NADH dehydrogenase activity 16/2571 44/18639 0.363636363636364 2.63625755807786 0.00014759308081248 0.0171744675854522 GO:0098632 cell-cell adhesion mediator activity 18/2571 55/18639 0.327272727272727 2.37263180227008 0.00027153653671427 0.0289638972495221 GO:0003779 actin binding 85/2571 443/18639 0.191873589164786 1.39102754898578 0.000872079677528211 0.08586630671047 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 19/2571 67/18639 0.283582089552239 2.05588742402341 0.00136296360474269 0.124613815290761 GO:0098641 cadherin binding involved in cell-cell adhesion 8/2571 18/18639 0.444444444444444 3.22209257098405 0.00155905908615644 0.128971774412348 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 17/2571 58/18639 0.293103448275862 2.12491449724379 0.00161214718015435 0.128971774412348 GO:0017081 chloride channel regulator activity 7/2571 15/18639 0.466666666666667 3.38319719953326 0.00219376704382648 0.135762269704088 GO:0098631 cell adhesion mediator activity 20/2571 76/18639 0.263157894736842 1.90781796966161 0.00276519065520806 0.135762269704088 GO:0030695 GTPase regulator activity 89/2571 489/18639 0.18200408997955 1.3194765589766 0.00339675903366917 0.135762269704088 GO:0030275 LRR domain binding 7/2571 16/18639 0.4375 3.17174737456243 0.00343910316075116 0.135762269704088 GO:0016651 oxidoreductase activity, acting on NAD(P)H 22/2571 88/18639 0.25 1.81242707117853 0.00349435550354861 0.135762269704088 GO:0060589 nucleoside-triphosphatase regulator activity 89/2571 490/18639 0.181632653061225 1.31678374967256 0.00360178035538896 0.135762269704088 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 49/2571 243/18639 0.201646090534979 1.46187533313165 0.0036800862257856 0.135762269704088 GO:0106310 protein serine kinase activity 68/2571 361/18639 0.188365650969529 1.36559602038936 0.00426910371695062 0.135762269704088 GO:0004676 3-phosphoinositide-dependent protein kinase activity 49/2571 245/18639 0.2 1.44994165694282 0.00434863520145906 0.135762269704088 GO:0004711 ribosomal protein S6 kinase activity 49/2571 245/18639 0.2 1.44994165694282 0.00434863520145906 0.135762269704088 GO:0035175 histone H3S10 kinase activity 49/2571 245/18639 0.2 1.44994165694282 0.00434863520145906 0.135762269704088 GO:0035979 histone H2AXS139 kinase activity 49/2571 245/18639 0.2 1.44994165694282 0.00434863520145906 0.135762269704088 GO:0044022 histone H3S28 kinase activity 49/2571 245/18639 0.2 1.44994165694282 0.00434863520145906 0.135762269704088 GO:0044023 histone H4S1 kinase activity 49/2571 245/18639 0.2 1.44994165694282 0.00434863520145906 0.135762269704088 GO:0044024 histone H2AS1 kinase activity 49/2571 245/18639 0.2 1.44994165694282 0.00434863520145906 0.135762269704088 GO:0044025 histone H2BS14 kinase activity 49/2571 245/18639 0.2 1.44994165694282 0.00434863520145906 0.135762269704088 GO:0072354 histone H3T3 kinase activity 49/2571 245/18639 0.2 1.44994165694282 0.00434863520145906 0.135762269704088 GO:0072371 histone H2AS121 kinase activity 49/2571 245/18639 0.2 1.44994165694282 0.00434863520145906 0.135762269704088 GO:0072518 Rho-dependent protein serine/threonine kinase activity 49/2571 245/18639 0.2 1.44994165694282 0.00434863520145906 0.135762269704088 GO:0140823 histone H2BS36 kinase activity 49/2571 245/18639 0.2 1.44994165694282 0.00434863520145906 0.135762269704088 GO:0140855 histone H3S57 kinase activity 49/2571 245/18639 0.2 1.44994165694282 0.00434863520145906 0.135762269704088 GO:0140995 histone H2A kinase activity 49/2571 245/18639 0.2 1.44994165694282 0.00434863520145906 0.135762269704088 GO:0140997 histone H4 kinase activity 49/2571 245/18639 0.2 1.44994165694282 0.00434863520145906 0.135762269704088 GO:0140998 histone H2B kinase activity 49/2571 245/18639 0.2 1.44994165694282 0.00434863520145906 0.135762269704088 GO:1990244 histone H2AT120 kinase activity 49/2571 245/18639 0.2 1.44994165694282 0.00434863520145906 0.135762269704088 GO:0004677 DNA-dependent protein kinase activity 49/2571 246/18639 0.199186991869919 1.44404758516663 0.00472019340304063 0.140508082695163 GO:0140857 histone H3T45 kinase activity 49/2571 246/18639 0.199186991869919 1.44404758516663 0.00472019340304063 0.140508082695163 GO:0015297 antiporter activity 30/2571 135/18639 0.222222222222222 1.61104628549203 0.00502182984686656 0.142428616996062 GO:0035402 histone H3T11 kinase activity 49/2571 247/18639 0.198380566801619 1.43820123866798 0.00511852842329597 0.142428616996062 GO:0035403 histone H3T6 kinase activity 49/2571 247/18639 0.198380566801619 1.43820123866798 0.00511852842329597 0.142428616996062 GO:0004679 AMP-activated protein kinase activity 49/2571 248/18639 0.19758064516129 1.43240204012497 0.00554514756252971 0.15101678468166 GO:0160215 deacylase activity 17/2571 65/18639 0.261538461538462 1.89607755138677 0.00593206977235284 0.156716404230455 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 16/2571 60/18639 0.266666666666667 1.93325554259043 0.00611789568569173 0.156716404230455 GO:0141003 histone H2AX kinase activity 66/2571 354/18639 0.186440677966102 1.35164052765856 0.00612173454025214 0.156716404230455 GO:0015291 secondary active transmembrane transporter activity 55/2571 287/18639 0.191637630662021 1.38931691867344 0.00663749850226008 0.166588197703782 GO:0140996 histone H3 kinase activity 66/2571 357/18639 0.184873949579832 1.34028220389673 0.00742069272329641 0.182663205496527 GO:0044548 S100 protein binding 6/2571 14/18639 0.428571428571429 3.10701783630605 0.0076190629132078 0.184007557149169 GO:0051020 GTPase binding 59/2571 315/18639 0.187301587301587 1.35788186920042 0.00830612699142585 0.196885973130094 GO:0035173 histone kinase activity 66/2571 360/18639 0.183333333333333 1.32911318553092 0.00894624596263174 0.207667992508014 GO:0005283 amino acid:sodium symporter activity 8/2571 23/18639 0.347826086956522 2.52163766424839 0.00924771529137252 0.207667992508014 GO:0140103 catalytic activity, acting on a glycoprotein 8/2571 23/18639 0.347826086956522 2.52163766424839 0.00924771529137252 0.207667992508014 GO:0019888 protein phosphatase regulator activity 24/2571 107/18639 0.224299065420561 1.62610279283307 0.0100224241760587 0.221184533540605 GO:1901505 carbohydrate derivative transmembrane transporter activity 14/2571 53/18639 0.264150943396226 1.91501728275467 0.0108840400716288 0.230924857997021 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 5/2571 11/18639 0.454545454545455 3.29532194759733 0.0111470090146664 0.230924857997021 GO:0043522 leucine zipper domain binding 5/2571 11/18639 0.454545454545455 3.29532194759733 0.0111470090146664 0.230924857997021 GO:0004129 cytochrome-c oxidase activity 6/2571 15/18639 0.4 2.89988331388565 0.0112359268261287 0.230924857997021 GO:0008200 ion channel inhibitor activity 12/2571 43/18639 0.27906976744186 2.0231744050365 0.0113658328545409 0.230924857997021 GO:0031267 small GTPase binding 53/2571 283/18639 0.187279151943463 1.35771921939876 0.0118815842974769 0.232121295970995 GO:0016209 antioxidant activity 20/2571 86/18639 0.232558139534884 1.68597867086375 0.0119687543235044 0.232121295970995 GO:0050660 flavin adenine dinucleotide binding 20/2571 86/18639 0.232558139534884 1.68597867086375 0.0119687543235044 0.232121295970995 GO:0004622 lysophospholipase activity 8/2571 24/18639 0.333333333333333 2.41656942823804 0.0122259726557995 0.233570820886916 GO:0043236 laminin binding 9/2571 29/18639 0.310344827586207 2.2499094676699 0.0132811109174875 0.249997381976235 GO:0016248 channel inhibitor activity 12/2571 44/18639 0.272727272727273 1.9771931685584 0.0137138789905125 0.250768072969371 GO:0016790 thiolester hydrolase activity 12/2571 44/18639 0.272727272727273 1.9771931685584 0.0137138789905125 0.250768072969371 GO:0015294 solute:monoatomic cation symporter activity 25/2571 116/18639 0.21551724137931 1.56243713032632 0.014397751443413 0.259565096444629 GO:0004674 protein serine/threonine kinase activity 76/2571 433/18639 0.175519630484988 1.27246611925698 0.0150965012444555 0.264544765096814 GO:0047617 fatty acyl-CoA hydrolase activity 8/2571 25/18639 0.32 2.31990665110852 0.0158516625426105 0.264544765096814 GO:0005324 long-chain fatty acid transmembrane transporter activity 6/2571 16/18639 0.375 2.71864060676779 0.0159140210253552 0.264544765096814 GO:0016675 oxidoreductase activity, acting on a heme group of donors 6/2571 16/18639 0.375 2.71864060676779 0.0159140210253552 0.264544765096814 GO:0016722 oxidoreductase activity, acting on metal ions 6/2571 16/18639 0.375 2.71864060676779 0.0159140210253552 0.264544765096814 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 6/2571 16/18639 0.375 2.71864060676779 0.0159140210253552 0.264544765096814 GO:0141110 transporter inhibitor activity 12/2571 45/18639 0.266666666666667 1.93325554259043 0.0164137637506767 0.264859882565262 GO:0000995 RNA polymerase III general transcription initiation factor activity 5/2571 12/18639 0.416666666666667 3.02071178529755 0.0169675862268371 0.264859882565262 GO:0004859 phospholipase inhibitor activity 5/2571 12/18639 0.416666666666667 3.02071178529755 0.0169675862268371 0.264859882565262 GO:0035014 phosphatidylinositol 3-kinase regulator activity 5/2571 12/18639 0.416666666666667 3.02071178529755 0.0169675862268371 0.264859882565262 GO:0045295 gamma-catenin binding 5/2571 12/18639 0.416666666666667 3.02071178529755 0.0169675862268371 0.264859882565262 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 7/2571 21/18639 0.333333333333333 2.41656942823804 0.0187395600328119 0.282195727552933 GO:0010314 phosphatidylinositol-5-phosphate binding 7/2571 21/18639 0.333333333333333 2.41656942823804 0.0187395600328119 0.282195727552933 GO:0019200 carbohydrate kinase activity 7/2571 21/18639 0.333333333333333 2.41656942823804 0.0187395600328119 0.282195727552933 GO:0016289 acyl-CoA hydrolase activity 8/2571 26/18639 0.307692307692308 2.23067947221973 0.0201939697347183 0.297252425054671 GO:0015175 neutral L-amino acid transmembrane transporter activity 11/2571 41/18639 0.268292682926829 1.94504368614281 0.0202038757654347 0.297252425054671 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 6/2571 17/18639 0.352941176470588 2.55872057107557 0.021781317996446 0.308696993493555 GO:0008429 phosphatidylethanolamine binding 6/2571 17/18639 0.352941176470588 2.55872057107557 0.021781317996446 0.308696993493555 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 6/2571 17/18639 0.352941176470588 2.55872057107557 0.021781317996446 0.308696993493555 GO:0019903 protein phosphatase binding 29/2571 144/18639 0.201388888888889 1.46001069622715 0.0219464268811824 0.308696993493555 GO:0019855 calcium channel inhibitor activity 5/2571 13/18639 0.384615384615385 2.78834934027466 0.0244957139933593 0.340809933820651 GO:0019208 phosphatase regulator activity 24/2571 117/18639 0.205128205128205 1.48711964814649 0.0284560475354304 0.383645122957767 GO:0017075 syntaxin-1 binding 6/2571 18/18639 0.333333333333333 2.41656942823804 0.0289484240488826 0.383645122957767 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 6/2571 18/18639 0.333333333333333 2.41656942823804 0.0289484240488826 0.383645122957767 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 6/2571 18/18639 0.333333333333333 2.41656942823804 0.0289484240488826 0.383645122957767 GO:0051015 actin filament binding 39/2571 209/18639 0.186602870813397 1.35281637848732 0.0291095051091605 0.383645122957767 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 9/2571 33/18639 0.272727272727273 1.9771931685584 0.0307893784010143 0.383645122957767 GO:0030296 protein tyrosine kinase activator activity 9/2571 33/18639 0.272727272727273 1.9771931685584 0.0307893784010143 0.383645122957767 GO:0140416 transcription regulator inhibitor activity 9/2571 33/18639 0.272727272727273 1.9771931685584 0.0307893784010143 0.383645122957767 GO:0004602 glutathione peroxidase activity 7/2571 23/18639 0.304347826086957 2.20643295621734 0.0308714434880078 0.383645122957767 GO:0042171 lysophosphatidic acid acyltransferase activity 7/2571 23/18639 0.304347826086957 2.20643295621734 0.0308714434880078 0.383645122957767 GO:0071617 lysophospholipid acyltransferase activity 7/2571 23/18639 0.304347826086957 2.20643295621734 0.0308714434880078 0.383645122957767 GO:0005161 platelet-derived growth factor receptor binding 5/2571 14/18639 0.357142857142857 2.58918153025504 0.0338716312601101 0.409015924650386 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 5/2571 14/18639 0.357142857142857 2.58918153025504 0.0338716312601101 0.409015924650386 GO:0071933 Arp2/3 complex binding 5/2571 14/18639 0.357142857142857 2.58918153025504 0.0338716312601101 0.409015924650386 GO:0016247 channel regulator activity 32/2571 168/18639 0.19047619047619 1.38089681613602 0.0347308595950037 0.415471965248642 GO:0015245 fatty acid transmembrane transporter activity 6/2571 19/18639 0.315789473684211 2.28938156359393 0.0375051444844644 0.425368168841602 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 4/2571 10/18639 0.4 2.89988331388565 0.0380259262565195 0.425368168841602 GO:0015658 branched-chain amino acid transmembrane transporter activity 4/2571 10/18639 0.4 2.89988331388565 0.0380259262565195 0.425368168841602 GO:0016783 sulfurtransferase activity 4/2571 10/18639 0.4 2.89988331388565 0.0380259262565195 0.425368168841602 GO:0031434 mitogen-activated protein kinase kinase binding 4/2571 10/18639 0.4 2.89988331388565 0.0380259262565195 0.425368168841602 GO:0005416 amino acid:monoatomic cation symporter activity 8/2571 29/18639 0.275862068965517 1.99991952681769 0.0381402226357721 0.425368168841602 GO:0005315 phosphate transmembrane transporter activity 7/2571 24/18639 0.291666666666667 2.11449824970828 0.0385489903012702 0.425368168841602 GO:0015295 solute:proton symporter activity 7/2571 24/18639 0.291666666666667 2.11449824970828 0.0385489903012702 0.425368168841602 GO:0070300 phosphatidic acid binding 7/2571 24/18639 0.291666666666667 2.11449824970828 0.0385489903012702 0.425368168841602 GO:0015370 solute:sodium symporter activity 17/2571 79/18639 0.215189873417722 1.56006380810304 0.0392301406349562 0.429184444553367 GO:0141108 transporter regulator activity 32/2571 170/18639 0.188235294117647 1.3646509712403 0.0401529451365065 0.435557370972274 GO:0071949 FAD binding 10/2571 40/18639 0.25 1.81242707117853 0.0413711716001277 0.445000837379525 GO:0048306 calcium-dependent protein binding 17/2571 80/18639 0.2125 1.54056301050175 0.0436474600769322 0.455453061816449 GO:0015103 inorganic anion transmembrane transporter activity 31/2571 165/18639 0.187878787878788 1.36206640500689 0.0438055560059249 0.455453061816449 GO:0005343 organic acid:sodium symporter activity 9/2571 35/18639 0.257142857142857 1.86421070178363 0.0438176626628861 0.455453061816449 GO:0004601 peroxidase activity 13/2571 57/18639 0.228070175438596 1.6534422403734 0.0438298057959154 0.455453061816449 GO:0016791 phosphatase activity 48/2571 273/18639 0.175824175824176 1.27467398412556 0.0442201877770433 0.455453061816449 GO:0003774 cytoskeletal motor activity 29/2571 153/18639 0.189542483660131 1.37412771409614 0.0451802650706306 0.455453061816449 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 5/2571 15/18639 0.333333333333333 2.41656942823804 0.0451894834771008 0.455453061816449 GO:0048531 beta-1,3-galactosyltransferase activity 5/2571 15/18639 0.333333333333333 2.41656942823804 0.0451894834771008 0.455453061816449 GO:0005543 phospholipid binding 82/2571 497/18639 0.164989939637827 1.19612893228684 0.046401884137948 0.463570474723179 GO:0015095 magnesium ion transmembrane transporter activity 6/2571 20/18639 0.3 2.17491248541424 0.0475181289300377 0.463570474723179 GO:0052745 inositol phosphate phosphatase activity 6/2571 20/18639 0.3 2.17491248541424 0.0475181289300377 0.463570474723179 GO:0005080 protein kinase C binding 12/2571 52/18639 0.230769230769231 1.6730096041648 0.0475651730249718 0.463570474723179 GO:0099106 ion channel regulator activity 30/2571 160/18639 0.1875 1.3593203033839 0.0478057052058278 0.463570474723179 GO:0140828 metal cation:monoatomic cation antiporter activity 10/2571 41/18639 0.24390243902439 1.7682215328571 0.0481993315468028 0.463873266014342 GO:0005484 SNAP receptor activity 9/2571 36/18639 0.25 1.81242707117853 0.0515357872715131 0.49228214707117 GO:0000099 sulfur amino acid transmembrane transporter activity 4/2571 11/18639 0.363636363636364 2.63625755807786 0.0533853075375783 0.495168069913769 GO:0002162 dystroglycan binding 4/2571 11/18639 0.363636363636364 2.63625755807786 0.0533853075375783 0.495168069913769 GO:0003953 NAD+ nucleosidase activity 4/2571 11/18639 0.363636363636364 2.63625755807786 0.0533853075375783 0.495168069913769 GO:0045294 alpha-catenin binding 4/2571 11/18639 0.363636363636364 2.63625755807786 0.0533853075375783 0.495168069913769 GO:0004864 protein phosphatase inhibitor activity 12/2571 53/18639 0.226415094339623 1.64144338521829 0.0540682027086246 0.495864471432119 GO:0005452 solute:inorganic anion antiporter activity 8/2571 31/18639 0.258064516129032 1.87089246057139 0.0547016689593783 0.495864471432119 GO:0016411 acylglycerol O-acyltransferase activity 8/2571 31/18639 0.258064516129032 1.87089246057139 0.0547016689593783 0.495864471432119 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 13/2571 59/18639 0.220338983050847 1.59739335086921 0.0559316053367121 0.495864471432119 GO:0031593 polyubiquitin modification-dependent protein binding 13/2571 59/18639 0.220338983050847 1.59739335086921 0.0559316053367121 0.495864471432119 GO:0035091 phosphatidylinositol binding 49/2571 284/18639 0.172535211267606 1.25082995053166 0.0560974674090743 0.495864471432119 GO:0008157 protein phosphatase 1 binding 7/2571 26/18639 0.269230769230769 1.95184453819226 0.0573900611885848 0.495864471432119 GO:0034237 protein kinase A regulatory subunit binding 7/2571 26/18639 0.269230769230769 1.95184453819226 0.0573900611885848 0.495864471432119 GO:0051139 metal cation:proton antiporter activity 7/2571 26/18639 0.269230769230769 1.95184453819226 0.0573900611885848 0.495864471432119 GO:0005159 insulin-like growth factor receptor binding 5/2571 16/18639 0.3125 2.26553383897316 0.0584965118642578 0.495864471432119 GO:0031435 mitogen-activated protein kinase kinase kinase binding 5/2571 16/18639 0.3125 2.26553383897316 0.0584965118642578 0.495864471432119 GO:0055102 lipase inhibitor activity 5/2571 16/18639 0.3125 2.26553383897316 0.0584965118642578 0.495864471432119 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 5/2571 16/18639 0.3125 2.26553383897316 0.0584965118642578 0.495864471432119 GO:0019213 deacetylase activity 9/2571 37/18639 0.243243243243243 1.76344255574127 0.0600924557936629 0.506041732999266 GO:0015081 sodium ion transmembrane transporter activity 30/2571 164/18639 0.182926829268293 1.32616614964283 0.0628213871461571 0.525564546059353 GO:0008375 acetylglucosaminyltransferase activity 10/2571 43/18639 0.232558139534884 1.68597867086375 0.0640223026955382 0.532133425001876 GO:0019902 phosphatase binding 34/2571 190/18639 0.178947368421053 1.2973162193699 0.0651937465704638 0.538374165227056 GO:0015293 symporter activity 27/2571 146/18639 0.184931506849315 1.34069947731015 0.0667537012243017 0.542856160435344 GO:0004683 calcium/calmodulin-dependent protein kinase activity 7/2571 27/18639 0.259259259259259 1.8795539997407 0.0686153351965409 0.542856160435344 GO:0015252 proton channel activity 7/2571 27/18639 0.259259259259259 1.8795539997407 0.0686153351965409 0.542856160435344 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 7/2571 27/18639 0.259259259259259 1.8795539997407 0.0686153351965409 0.542856160435344 GO:0035255 ionotropic glutamate receptor binding 7/2571 27/18639 0.259259259259259 1.8795539997407 0.0686153351965409 0.542856160435344 GO:0003995 acyl-CoA dehydrogenase activity 4/2571 12/18639 0.333333333333333 2.41656942823804 0.071594168192949 0.542856160435344 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 4/2571 12/18639 0.333333333333333 2.41656942823804 0.071594168192949 0.542856160435344 GO:0017166 vinculin binding 4/2571 12/18639 0.333333333333333 2.41656942823804 0.071594168192949 0.542856160435344 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 4/2571 12/18639 0.333333333333333 2.41656942823804 0.071594168192949 0.542856160435344 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 4/2571 12/18639 0.333333333333333 2.41656942823804 0.071594168192949 0.542856160435344 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 4/2571 12/18639 0.333333333333333 2.41656942823804 0.071594168192949 0.542856160435344 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 23/2571 122/18639 0.188524590163934 1.36674828318381 0.0718429466685079 0.542856160435344 GO:0004407 histone deacetylase activity 6/2571 22/18639 0.272727272727273 1.9771931685584 0.0720567743649761 0.542856160435344 GO:0033558 protein lysine deacetylase activity 6/2571 22/18639 0.272727272727273 1.9771931685584 0.0720567743649761 0.542856160435344 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 5/2571 17/18639 0.294117647058824 2.13226714256298 0.0737945093091795 0.542856160435344 GO:0017110 nucleoside diphosphate phosphatase activity 5/2571 17/18639 0.294117647058824 2.13226714256298 0.0737945093091795 0.542856160435344 GO:0019198 transmembrane receptor protein phosphatase activity 5/2571 17/18639 0.294117647058824 2.13226714256298 0.0737945093091795 0.542856160435344 GO:0048038 quinone binding 5/2571 17/18639 0.294117647058824 2.13226714256298 0.0737945093091795 0.542856160435344 GO:0070403 NAD+ binding 5/2571 17/18639 0.294117647058824 2.13226714256298 0.0737945093091795 0.542856160435344 GO:0071889 14-3-3 protein binding 8/2571 33/18639 0.242424242424242 1.75750503871857 0.0752420898871806 0.550342143174806 GO:0035591 signaling adaptor activity 24/2571 129/18639 0.186046511627907 1.348782936691 0.0758782366084793 0.55184172078894 GO:0019212 phosphatase inhibitor activity 12/2571 56/18639 0.214285714285714 1.55350891815303 0.0770672209476968 0.557322275779954 GO:0003777 microtubule motor activity 14/2571 68/18639 0.205882352941176 1.49258699979408 0.078446626455216 0.564110572262227 GO:0001217 DNA-binding transcription repressor activity 47/2571 278/18639 0.169064748201439 1.22567010568908 0.0792522304304186 0.566320085253502 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 9/2571 39/18639 0.230769230769231 1.6730096041648 0.0797875001744305 0.566320085253502 GO:1902936 phosphatidylinositol bisphosphate binding 21/2571 111/18639 0.189189189189189 1.37156643224321 0.0800998632612354 0.566320085253502 GO:0051019 mitogen-activated protein kinase binding 7/2571 28/18639 0.25 1.81242707117853 0.0810596013805473 0.566320085253502 GO:0051537 2 iron, 2 sulfur cluster binding 7/2571 28/18639 0.25 1.81242707117853 0.0810596013805473 0.566320085253502 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 24/2571 130/18639 0.184615384615385 1.33840768333184 0.0814085122551909 0.566320085253502 GO:0046915 transition metal ion transmembrane transporter activity 10/2571 45/18639 0.222222222222222 1.61104628549203 0.0828379940839891 0.573149364473006 GO:0004721 phosphoprotein phosphatase activity 31/2571 175/18639 0.177142857142857 1.2842340390065 0.0838216976779354 0.576837489396545 GO:0052866 phosphatidylinositol phosphate phosphatase activity 8/2571 34/18639 0.235294117647059 1.70581371405038 0.0870357189129302 0.595752514484228 GO:0043130 ubiquitin binding 19/2571 100/18639 0.19 1.37744457409568 0.0894281748160132 0.608872679598388 GO:0008308 voltage-gated monoatomic anion channel activity 5/2571 18/18639 0.277777777777778 2.01380785686503 0.091043003640063 0.613342340312003 GO:0030228 lipoprotein particle receptor activity 5/2571 18/18639 0.277777777777778 2.01380785686503 0.091043003640063 0.613342340312003 GO:0005172 vascular endothelial growth factor receptor binding 4/2571 13/18639 0.307692307692308 2.23067947221973 0.0925268145038777 0.613649339714837 GO:0035673 oligopeptide transmembrane transporter activity 4/2571 13/18639 0.307692307692308 2.23067947221973 0.0925268145038777 0.613649339714837 GO:0043560 insulin receptor substrate binding 4/2571 13/18639 0.307692307692308 2.23067947221973 0.0925268145038777 0.613649339714837 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 24/2571 132/18639 0.181818181818182 1.31812877903893 0.0932641453352474 0.615351062005756 GO:0030295 protein kinase activator activity 25/2571 139/18639 0.179856115107914 1.30390436775434 0.0972123695106442 0.638111963967306 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 77/2571 484/18639 0.159090909090909 1.15336268165906 0.0983141026129443 0.642051282370249 GO:0004519 endonuclease activity 23/2571 127/18639 0.181102362204724 1.31293929565689 0.102011442377383 0.652430050872315 GO:1901981 phosphatidylinositol phosphate binding 32/2571 185/18639 0.172972972972973 1.25400359519379 0.102380291049013 0.652430050872315 GO:0042625 ATPase-coupled ion transmembrane transporter activity 6/2571 24/18639 0.25 1.81242707117853 0.102607367896941 0.652430050872315 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 6/2571 24/18639 0.25 1.81242707117853 0.102607367896941 0.652430050872315 GO:0046961 proton-transporting ATPase activity, rotational mechanism 6/2571 24/18639 0.25 1.81242707117853 0.102607367896941 0.652430050872315 GO:0017080 sodium channel regulator activity 9/2571 41/18639 0.219512195121951 1.59139937957139 0.102961617403287 0.652430050872315 GO:0004713 protein tyrosine kinase activity 25/2571 140/18639 0.178571428571429 1.29459076512752 0.103550780242465 0.652931028129831 GO:0001784 phosphotyrosine residue binding 10/2571 47/18639 0.212765957446809 1.54249112440726 0.104695155113249 0.656910777181173 GO:0001786 phosphatidylserine binding 12/2571 59/18639 0.203389830508475 1.47451693926389 0.10547809839458 0.658594955829575 GO:0008381 mechanosensitive monoatomic ion channel activity 5/2571 19/18639 0.263157894736842 1.90781796966161 0.110163667624205 0.681205287724555 GO:0042577 lipid phosphatase activity 5/2571 19/18639 0.263157894736842 1.90781796966161 0.110163667624205 0.681205287724555 GO:0045505 dynein intermediate chain binding 8/2571 36/18639 0.222222222222222 1.61104628549203 0.113642577953352 0.69522352958207 GO:0008195 phosphatidate phosphatase activity 4/2571 14/18639 0.285714285714286 2.07134522420403 0.115988887801385 0.69522352958207 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 4/2571 14/18639 0.285714285714286 2.07134522420403 0.115988887801385 0.69522352958207 GO:0046030 inositol trisphosphate phosphatase activity 4/2571 14/18639 0.285714285714286 2.07134522420403 0.115988887801385 0.69522352958207 GO:0098847 sequence-specific single stranded DNA binding 4/2571 14/18639 0.285714285714286 2.07134522420403 0.115988887801385 0.69522352958207 GO:0016879 ligase activity, forming carbon-nitrogen bonds 10/2571 48/18639 0.208333333333333 1.51035589264877 0.116755155928287 0.69522352958207 GO:0032266 phosphatidylinositol-3-phosphate binding 10/2571 48/18639 0.208333333333333 1.51035589264877 0.116755155928287 0.69522352958207 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 11/2571 54/18639 0.203703703703704 1.47679242836769 0.116775827234488 0.69522352958207 GO:0019207 kinase regulator activity 47/2571 287/18639 0.163763066202091 1.18723445777548 0.117963115500394 0.69904068444678 GO:0004857 enzyme inhibitor activity 66/2571 416/18639 0.158653846153846 1.1501941028633 0.122578375606279 0.720344100411081 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 44/2571 268/18639 0.164179104477612 1.19025061390829 0.123135049538698 0.720344100411081 GO:0001216 DNA-binding transcription activator activity 77/2571 491/18639 0.156822810590631 1.13691962917105 0.123246373429708 0.720344100411081 GO:0047499 calcium-independent phospholipase A2 activity 7/2571 31/18639 0.225806451612903 1.63703090299996 0.12556306679814 0.730548752280088 GO:0016836 hydro-lyase activity 12/2571 61/18639 0.19672131147541 1.42617212158311 0.127435691454386 0.733584798157568 GO:0042578 phosphoric ester hydrolase activity 58/2571 363/18639 0.159779614325069 1.15835559370088 0.127691062989051 0.733584798157568 GO:0019842 vitamin binding 26/2571 150/18639 0.173333333333333 1.25661610268378 0.127804226554014 0.733584798157568 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 16/2571 86/18639 0.186046511627907 1.348782936691 0.128727037933968 0.735583073908391 GO:0060590 ATPase regulator activity 10/2571 49/18639 0.204081632653061 1.47953230300288 0.129553528213641 0.736663953070911 GO:0008017 microtubule binding 45/2571 276/18639 0.16304347826087 1.18201765511643 0.130067229214083 0.736663953070911 GO:0000049 tRNA binding 15/2571 80/18639 0.1875 1.3593203033839 0.131546014182765 0.741443633049023 GO:0032934 sterol binding 13/2571 68/18639 0.191176470588235 1.38597364266593 0.136891852311561 0.741443633049023 GO:0015179 L-amino acid transmembrane transporter activity 12/2571 62/18639 0.193548387096774 1.40316934542854 0.139298525652955 0.741443633049023 GO:0000774 adenyl-nucleotide exchange factor activity 4/2571 15/18639 0.266666666666667 1.93325554259043 0.141734125737488 0.741443633049023 GO:0004089 carbonate dehydratase activity 4/2571 15/18639 0.266666666666667 1.93325554259043 0.141734125737488 0.741443633049023 GO:0005041 low-density lipoprotein particle receptor activity 4/2571 15/18639 0.266666666666667 1.93325554259043 0.141734125737488 0.741443633049023 GO:0005402 carbohydrate:monoatomic cation symporter activity 4/2571 15/18639 0.266666666666667 1.93325554259043 0.141734125737488 0.741443633049023 GO:0047372 monoacylglycerol lipase activity 4/2571 15/18639 0.266666666666667 1.93325554259043 0.141734125737488 0.741443633049023 GO:0140776 protein-containing complex destabilizing activity 4/2571 15/18639 0.266666666666667 1.93325554259043 0.141734125737488 0.741443633049023 GO:0141050 histone H3K deacetylase activity 4/2571 15/18639 0.266666666666667 1.93325554259043 0.141734125737488 0.741443633049023 GO:0141051 histone H4K deacetylase activity 4/2571 15/18639 0.266666666666667 1.93325554259043 0.141734125737488 0.741443633049023 GO:0001618 virus receptor activity 15/2571 81/18639 0.185185185185185 1.34253857124336 0.141993266169728 0.741443633049023 GO:0047498 calcium-dependent phospholipase A2 activity 7/2571 32/18639 0.21875 1.58587368728121 0.142670336506815 0.741443633049023 GO:0001223 transcription coactivator binding 9/2571 44/18639 0.204545454545455 1.4828948764188 0.144085430869833 0.741443633049023 GO:0019205 nucleobase-containing compound kinase activity 9/2571 44/18639 0.204545454545455 1.4828948764188 0.144085430869833 0.741443633049023 GO:0032182 ubiquitin-like protein binding 21/2571 120/18639 0.175 1.26869894982497 0.147524466712605 0.741443633049023 GO:0004382 GDP phosphatase activity 3/2571 10/18639 0.3 2.17491248541424 0.149447232286444 0.741443633049023 GO:0004445 inositol-polyphosphate 5-phosphatase activity 3/2571 10/18639 0.3 2.17491248541424 0.149447232286444 0.741443633049023 GO:0005345 purine nucleobase transmembrane transporter activity 3/2571 10/18639 0.3 2.17491248541424 0.149447232286444 0.741443633049023 GO:0005381 iron ion transmembrane transporter activity 3/2571 10/18639 0.3 2.17491248541424 0.149447232286444 0.741443633049023 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 3/2571 10/18639 0.3 2.17491248541424 0.149447232286444 0.741443633049023 GO:0019911 structural constituent of myelin sheath 3/2571 10/18639 0.3 2.17491248541424 0.149447232286444 0.741443633049023 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 3/2571 10/18639 0.3 2.17491248541424 0.149447232286444 0.741443633049023 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 3/2571 10/18639 0.3 2.17491248541424 0.149447232286444 0.741443633049023 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 3/2571 10/18639 0.3 2.17491248541424 0.149447232286444 0.741443633049023 GO:0043121 neurotrophin binding 3/2571 10/18639 0.3 2.17491248541424 0.149447232286444 0.741443633049023 GO:0047429 nucleoside triphosphate diphosphatase activity 3/2571 10/18639 0.3 2.17491248541424 0.149447232286444 0.741443633049023 GO:0051864 histone H3K36 demethylase activity 3/2571 10/18639 0.3 2.17491248541424 0.149447232286444 0.741443633049023 GO:0070097 delta-catenin binding 3/2571 10/18639 0.3 2.17491248541424 0.149447232286444 0.741443633049023 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 3/2571 10/18639 0.3 2.17491248541424 0.149447232286444 0.741443633049023 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 3/2571 10/18639 0.3 2.17491248541424 0.149447232286444 0.741443633049023 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 3/2571 10/18639 0.3 2.17491248541424 0.149447232286444 0.741443633049023 GO:0140272 exogenous protein binding 15/2571 82/18639 0.182926829268293 1.32616614964283 0.152883955810696 0.753044600313516 GO:0005123 death receptor binding 5/2571 21/18639 0.238095238095238 1.72612102017003 0.153550500532678 0.753044600313516 GO:0051010 microtubule plus-end binding 5/2571 21/18639 0.238095238095238 1.72612102017003 0.153550500532678 0.753044600313516 GO:0004867 serine-type endopeptidase inhibitor activity 17/2571 95/18639 0.178947368421053 1.2973162193699 0.15528081119736 0.758623810429849 GO:0005496 steroid binding 19/2571 108/18639 0.175925925925926 1.27541164268119 0.156381340498694 0.759118332275764 GO:0051082 unfolded protein binding 21/2571 121/18639 0.173553719008264 1.25821383453716 0.156568156031876 0.759118332275764 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 16/2571 89/18639 0.179775280898876 1.30331834331939 0.159691423687031 0.76843993353158 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 16/2571 89/18639 0.179775280898876 1.30331834331939 0.159691423687031 0.76843993353158 GO:0008028 monocarboxylic acid transmembrane transporter activity 13/2571 70/18639 0.185714285714286 1.34637439573262 0.160801621553478 0.770884178233902 GO:0019209 kinase activator activity 25/2571 148/18639 0.168918918918919 1.22461288593144 0.16352579713799 0.781018732599356 GO:0046943 carboxylic acid transmembrane transporter activity 31/2571 188/18639 0.164893617021277 1.19543062141563 0.165207141043768 0.786115764074434 GO:0015631 tubulin binding 60/2571 385/18639 0.155844155844156 1.12982466774765 0.169320754230158 0.794631487899497 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 4/2571 16/18639 0.25 1.81242707117853 0.169479997028565 0.794631487899497 GO:0004707 MAP kinase activity 4/2571 16/18639 0.25 1.81242707117853 0.169479997028565 0.794631487899497 GO:0015385 sodium:proton antiporter activity 4/2571 16/18639 0.25 1.81242707117853 0.169479997028565 0.794631487899497 GO:0140793 histone H2AXY142 phosphatase activity 16/2571 90/18639 0.177777777777778 1.28883702839362 0.170820448335977 0.797993335292153 GO:0030159 signaling receptor complex adaptor activity 10/2571 52/18639 0.192307692307692 1.39417467013733 0.172168279437363 0.801365082472091 GO:0005342 organic acid transmembrane transporter activity 31/2571 189/18639 0.164021164021164 1.18910559167269 0.172871828098034 0.801724420164796 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 5/2571 22/18639 0.227272727272727 1.64766097379866 0.177519243523178 0.804753156630859 GO:0016881 acid-amino acid ligase activity 5/2571 22/18639 0.227272727272727 1.64766097379866 0.177519243523178 0.804753156630859 GO:0015036 disulfide oxidoreductase activity 8/2571 40/18639 0.2 1.44994165694282 0.178173708264333 0.804753156630859 GO:0051959 dynein light intermediate chain binding 6/2571 28/18639 0.214285714285714 1.55350891815303 0.180145334230682 0.804753156630859 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 6/2571 28/18639 0.214285714285714 1.55350891815303 0.180145334230682 0.804753156630859 GO:0097718 disordered domain specific binding 6/2571 28/18639 0.214285714285714 1.55350891815303 0.180145334230682 0.804753156630859 GO:0015459 potassium channel regulator activity 11/2571 59/18639 0.186440677966102 1.35164052765856 0.182996102816465 0.804753156630859 GO:0045309 protein phosphorylated amino acid binding 11/2571 59/18639 0.186440677966102 1.35164052765856 0.182996102816465 0.804753156630859 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 3/2571 11/18639 0.272727272727273 1.9771931685584 0.185470454067268 0.804753156630859 GO:0015173 aromatic amino acid transmembrane transporter activity 3/2571 11/18639 0.272727272727273 1.9771931685584 0.185470454067268 0.804753156630859 GO:0015205 nucleobase transmembrane transporter activity 3/2571 11/18639 0.272727272727273 1.9771931685584 0.185470454067268 0.804753156630859 GO:0015217 ADP transmembrane transporter activity 3/2571 11/18639 0.272727272727273 1.9771931685584 0.185470454067268 0.804753156630859 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 3/2571 11/18639 0.272727272727273 1.9771931685584 0.185470454067268 0.804753156630859 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 3/2571 11/18639 0.272727272727273 1.9771931685584 0.185470454067268 0.804753156630859 GO:0032050 clathrin heavy chain binding 3/2571 11/18639 0.272727272727273 1.9771931685584 0.185470454067268 0.804753156630859 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 3/2571 11/18639 0.272727272727273 1.9771931685584 0.185470454067268 0.804753156630859 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 3/2571 11/18639 0.272727272727273 1.9771931685584 0.185470454067268 0.804753156630859 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 3/2571 11/18639 0.272727272727273 1.9771931685584 0.185470454067268 0.804753156630859 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 3/2571 11/18639 0.272727272727273 1.9771931685584 0.185470454067268 0.804753156630859 GO:0061135 endopeptidase regulator activity 30/2571 184/18639 0.16304347826087 1.18201765511643 0.18643061148702 0.805135523977945 GO:0005544 calcium-dependent phospholipid binding 10/2571 53/18639 0.188679245283019 1.36786948768191 0.187685663423597 0.805135523977945 GO:0016860 intramolecular oxidoreductase activity 10/2571 53/18639 0.188679245283019 1.36786948768191 0.187685663423597 0.805135523977945 GO:0004725 protein tyrosine phosphatase activity 17/2571 98/18639 0.173469387755102 1.25760245755245 0.188074626304223 0.805135523977945 GO:0061733 protein-lysine-acetyltransferase activity 9/2571 47/18639 0.191489361702128 1.38824201196653 0.192212538077023 0.820106829128633 GO:0016835 carbon-oxygen lyase activity 14/2571 79/18639 0.177215189873418 1.2847584302025 0.19410358299054 0.820333223787705 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 8/2571 41/18639 0.195121951219512 1.41457722628568 0.196406942412465 0.820333223787705 GO:0005200 structural constituent of cytoskeleton 19/2571 112/18639 0.169642857142857 1.22986122687115 0.197957882399473 0.820333223787705 GO:0004659 prenyltransferase activity 4/2571 17/18639 0.235294117647059 1.70581371405038 0.198921685557606 0.820333223787705 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 4/2571 17/18639 0.235294117647059 1.70581371405038 0.198921685557606 0.820333223787705 GO:0008569 minus-end-directed microtubule motor activity 4/2571 17/18639 0.235294117647059 1.70581371405038 0.198921685557606 0.820333223787705 GO:0038191 neuropilin binding 4/2571 17/18639 0.235294117647059 1.70581371405038 0.198921685557606 0.820333223787705 GO:0004623 phospholipase A2 activity 7/2571 35/18639 0.2 1.44994165694282 0.199982751513475 0.820333223787705 GO:0005154 epidermal growth factor receptor binding 7/2571 35/18639 0.2 1.44994165694282 0.199982751513475 0.820333223787705 GO:0016757 glycosyltransferase activity 42/2571 267/18639 0.157303370786517 1.14040355040447 0.200019992321358 0.820333223787705 GO:0004521 RNA endonuclease activity 13/2571 73/18639 0.178082191780822 1.29104394111347 0.200336127398346 0.820333223787705 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 6/2571 29/18639 0.206896551724138 1.49993964511327 0.202431308200913 0.820333223787705 GO:0008171 O-methyltransferase activity 5/2571 23/18639 0.217391304347826 1.57602354015524 0.202776596307943 0.820333223787705 GO:0016849 phosphorus-oxygen lyase activity 5/2571 23/18639 0.217391304347826 1.57602354015524 0.202776596307943 0.820333223787705 GO:0043274 phospholipase binding 5/2571 23/18639 0.217391304347826 1.57602354015524 0.202776596307943 0.820333223787705 GO:0070577 lysine-acetylated histone binding 5/2571 23/18639 0.217391304347826 1.57602354015524 0.202776596307943 0.820333223787705 GO:0015485 cholesterol binding 10/2571 54/18639 0.185185185185185 1.34253857124336 0.203801535284758 0.820333223787705 GO:0051287 NAD binding 10/2571 54/18639 0.185185185185185 1.34253857124336 0.203801535284758 0.820333223787705 GO:0000149 SNARE binding 18/2571 106/18639 0.169811320754717 1.23108253891372 0.204651124143709 0.821170654871307 GO:0050840 extracellular matrix binding 12/2571 67/18639 0.17910447761194 1.29845521517268 0.206809353525786 0.827237414103143 GO:0005516 calmodulin binding 33/2571 207/18639 0.159420289855072 1.15575059611385 0.209294073947825 0.834568269947713 GO:0019887 protein kinase regulator activity 40/2571 255/18639 0.156862745098039 1.13720914270025 0.212069286865761 0.840207236042883 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 11/2571 61/18639 0.180327868852459 1.30732444478451 0.213524649946968 0.840207236042883 GO:0016874 ligase activity 27/2571 167/18639 0.161676646706587 1.17210852507354 0.21428679815194 0.840207236042883 GO:0016410 N-acyltransferase activity 16/2571 94/18639 0.170212765957447 1.23399289952581 0.219063821582288 0.840207236042883 GO:0016409 palmitoyltransferase activity 7/2571 36/18639 0.194444444444444 1.40966549980552 0.22082348306247 0.840207236042883 GO:0004866 endopeptidase inhibitor activity 26/2571 161/18639 0.161490683229814 1.17076034411532 0.221375592180436 0.840207236042883 GO:0030145 manganese ion binding 12/2571 68/18639 0.176470588235294 1.27936028553779 0.221791675214548 0.840207236042883 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 36/2571 229/18639 0.157205240174672 1.1396921320948 0.222340564866822 0.840207236042883 GO:0004300 enoyl-CoA hydratase activity 3/2571 12/18639 0.25 1.81242707117853 0.223429216025375 0.840207236042883 GO:0005078 MAP-kinase scaffold activity 3/2571 12/18639 0.25 1.81242707117853 0.223429216025375 0.840207236042883 GO:0005095 GTPase inhibitor activity 3/2571 12/18639 0.25 1.81242707117853 0.223429216025375 0.840207236042883 GO:0005436 sodium:phosphate symporter activity 3/2571 12/18639 0.25 1.81242707117853 0.223429216025375 0.840207236042883 GO:0016208 AMP binding 3/2571 12/18639 0.25 1.81242707117853 0.223429216025375 0.840207236042883 GO:0016423 tRNA (guanine) methyltransferase activity 3/2571 12/18639 0.25 1.81242707117853 0.223429216025375 0.840207236042883 GO:0035259 nuclear glucocorticoid receptor binding 3/2571 12/18639 0.25 1.81242707117853 0.223429216025375 0.840207236042883 GO:0042301 phosphate ion binding 3/2571 12/18639 0.25 1.81242707117853 0.223429216025375 0.840207236042883 GO:0043047 single-stranded telomeric DNA binding 3/2571 12/18639 0.25 1.81242707117853 0.223429216025375 0.840207236042883 GO:0141221 histone deacetylase activity, hydrolytic mechanism 3/2571 12/18639 0.25 1.81242707117853 0.223429216025375 0.840207236042883 GO:0008106 alcohol dehydrogenase (NADP+) activity 6/2571 30/18639 0.2 1.44994165694282 0.225648608752182 0.840207236042883 GO:0031624 ubiquitin conjugating enzyme binding 6/2571 30/18639 0.2 1.44994165694282 0.225648608752182 0.840207236042883 GO:0051721 protein phosphatase 2A binding 6/2571 30/18639 0.2 1.44994165694282 0.225648608752182 0.840207236042883 GO:0016763 pentosyltransferase activity 9/2571 49/18639 0.183673469387755 1.33157907270259 0.227642036788331 0.840207236042883 GO:0035254 glutamate receptor binding 9/2571 49/18639 0.183673469387755 1.33157907270259 0.227642036788331 0.840207236042883 GO:0019003 GDP binding 13/2571 75/18639 0.173333333333333 1.25661610268378 0.228898865937017 0.840207236042883 GO:0140033 acetylation-dependent protein binding 5/2571 24/18639 0.208333333333333 1.51035589264877 0.229136919573997 0.840207236042883 GO:0005096 GTPase activator activity 42/2571 271/18639 0.154981549815498 1.12357102567525 0.229436231590964 0.840207236042883 GO:0004706 JUN kinase kinase kinase activity 4/2571 18/18639 0.222222222222222 1.61104628549203 0.229744166105476 0.840207236042883 GO:0015172 acidic amino acid transmembrane transporter activity 4/2571 18/18639 0.222222222222222 1.61104628549203 0.229744166105476 0.840207236042883 GO:0017128 phospholipid scramblase activity 4/2571 18/18639 0.222222222222222 1.61104628549203 0.229744166105476 0.840207236042883 GO:0008509 monoatomic anion transmembrane transporter activity 24/2571 149/18639 0.161073825503356 1.16773824720227 0.236549519064906 0.861787252362197 GO:0008080 N-acetyltransferase activity 12/2571 69/18639 0.173913043478261 1.26081883212419 0.237202414248215 0.861787252362197 GO:0030170 pyridoxal phosphate binding 10/2571 56/18639 0.178571428571429 1.29459076512752 0.237664765690512 0.861787252362197 GO:0016758 hexosyltransferase activity 31/2571 197/18639 0.157360406091371 1.14081703972659 0.240778407970346 0.870611192661137 GO:1901682 sulfur compound transmembrane transporter activity 11/2571 63/18639 0.174603174603175 1.26582208145802 0.245992061251459 0.884214324763827 GO:0032813 tumor necrosis factor receptor superfamily binding 9/2571 50/18639 0.18 1.30494749124854 0.246206257702953 0.884214324763827 GO:0005253 monoatomic anion channel activity 17/2571 103/18639 0.16504854368932 1.19655379456447 0.249414076439271 0.884214324763827 GO:0001540 amyloid-beta binding 14/2571 83/18639 0.168674698795181 1.22284236127708 0.249442945139893 0.884214324763827 GO:0008135 translation factor activity, RNA binding 14/2571 83/18639 0.168674698795181 1.22284236127708 0.249442945139893 0.884214324763827 GO:0005164 tumor necrosis factor receptor binding 6/2571 31/18639 0.193548387096774 1.40316934542854 0.249669138821152 0.884214324763827 GO:0070273 phosphatidylinositol-4-phosphate binding 6/2571 31/18639 0.193548387096774 1.40316934542854 0.249669138821152 0.884214324763827 GO:0015932 nucleobase-containing compound transmembrane transporter activity 10/2571 57/18639 0.175438596491228 1.27187864644107 0.255322866253487 0.884214324763827 GO:0070279 vitamin B6 binding 10/2571 57/18639 0.175438596491228 1.27187864644107 0.255322866253487 0.884214324763827 GO:0042974 nuclear retinoic acid receptor binding 5/2571 25/18639 0.2 1.44994165694282 0.256408914938824 0.884214324763827 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 5/2571 25/18639 0.2 1.44994165694282 0.256408914938824 0.884214324763827 GO:0120020 cholesterol transfer activity 5/2571 25/18639 0.2 1.44994165694282 0.256408914938824 0.884214324763827 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 4/2571 19/18639 0.210526315789474 1.52625437572929 0.261632299033814 0.884214324763827 GO:0022821 solute:potassium antiporter activity 4/2571 19/18639 0.210526315789474 1.52625437572929 0.261632299033814 0.884214324763827 GO:0050145 nucleoside monophosphate kinase activity 4/2571 19/18639 0.210526315789474 1.52625437572929 0.261632299033814 0.884214324763827 GO:1990380 K48-linked deubiquitinase activity 4/2571 19/18639 0.210526315789474 1.52625437572929 0.261632299033814 0.884214324763827 GO:0005338 nucleotide-sugar transmembrane transporter activity 3/2571 13/18639 0.230769230769231 1.6730096041648 0.262699936481824 0.884214324763827 GO:0008035 high-density lipoprotein particle binding 3/2571 13/18639 0.230769230769231 1.6730096041648 0.262699936481824 0.884214324763827 GO:0017154 semaphorin receptor activity 3/2571 13/18639 0.230769230769231 1.6730096041648 0.262699936481824 0.884214324763827 GO:0019104 DNA N-glycosylase activity 3/2571 13/18639 0.230769230769231 1.6730096041648 0.262699936481824 0.884214324763827 GO:0031994 insulin-like growth factor I binding 3/2571 13/18639 0.230769230769231 1.6730096041648 0.262699936481824 0.884214324763827 GO:0035325 Toll-like receptor binding 3/2571 13/18639 0.230769230769231 1.6730096041648 0.262699936481824 0.884214324763827 GO:0051011 microtubule minus-end binding 3/2571 13/18639 0.230769230769231 1.6730096041648 0.262699936481824 0.884214324763827 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 3/2571 13/18639 0.230769230769231 1.6730096041648 0.262699936481824 0.884214324763827 GO:0089720 caspase binding 3/2571 13/18639 0.230769230769231 1.6730096041648 0.262699936481824 0.884214324763827 GO:0051117 ATPase binding 14/2571 84/18639 0.166666666666667 1.20828471411902 0.264140882950603 0.884214324763827 GO:0180051 translation factor activity 14/2571 84/18639 0.166666666666667 1.20828471411902 0.264140882950603 0.884214324763827 GO:0003924 GTPase activity 50/2571 331/18639 0.151057401812689 1.09512209738884 0.264485349176765 0.884214324763827 GO:0000146 microfilament motor activity 7/2571 38/18639 0.184210526315789 1.33547257876313 0.264573504987926 0.884214324763827 GO:0046873 metal ion transmembrane transporter activity 67/2571 450/18639 0.148888888888889 1.07940101127966 0.266734578527021 0.889115261756735 GO:0008514 organic anion transmembrane transporter activity 41/2571 269/18639 0.152416356877323 1.10497412517948 0.268342054803879 0.889572167551337 GO:0072341 modified amino acid binding 15/2571 91/18639 0.164835164835165 1.19500686011771 0.268608129792034 0.889572167551337 GO:0016829 lyase activity 31/2571 200/18639 0.155 1.12370478413069 0.268956585033099 0.889572167551337 GO:0042626 ATPase-coupled transmembrane transporter activity 16/2571 98/18639 0.163265306122449 1.1836258424023 0.272509942688604 0.895873208569668 GO:0140030 modification-dependent protein binding 27/2571 173/18639 0.15606936416185 1.13145736235423 0.273826101754197 0.895873208569668 GO:0008378 galactosyltransferase activity 6/2571 32/18639 0.1875 1.3593203033839 0.274361170124461 0.895873208569668 GO:0022884 macromolecule transmembrane transporter activity 6/2571 32/18639 0.1875 1.3593203033839 0.274361170124461 0.895873208569668 GO:0120015 sterol transfer activity 6/2571 32/18639 0.1875 1.3593203033839 0.274361170124461 0.895873208569668 GO:0140303 intramembrane lipid transporter activity 8/2571 45/18639 0.177777777777778 1.28883702839362 0.275884384989839 0.897483251674383 GO:0070851 growth factor receptor binding 22/2571 139/18639 0.158273381294964 1.14743584362382 0.276256563406021 0.897483251674383 GO:0019843 rRNA binding 11/2571 65/18639 0.169230769230769 1.22687370972085 0.280094644786507 0.90535642759275 GO:0038024 cargo receptor activity 11/2571 65/18639 0.169230769230769 1.22687370972085 0.280094644786507 0.90535642759275 GO:0004112 cyclic-nucleotide phosphodiesterase activity 5/2571 26/18639 0.192307692307692 1.39417467013733 0.284399942021278 0.914653079867428 GO:0043548 phosphatidylinositol 3-kinase binding 5/2571 26/18639 0.192307692307692 1.39417467013733 0.284399942021278 0.914653079867428 GO:0000287 magnesium ion binding 35/2571 230/18639 0.152173913043478 1.10321647810867 0.291189054263606 0.934140324454677 GO:0030742 GTP-dependent protein binding 4/2571 20/18639 0.2 1.44994165694282 0.294278995328369 0.935325479325537 GO:0031418 L-ascorbic acid binding 4/2571 20/18639 0.2 1.44994165694282 0.294278995328369 0.935325479325537 GO:0004180 carboxypeptidase activity 8/2571 46/18639 0.173913043478261 1.26081883212419 0.297027647034973 0.935325479325537 GO:0051213 dioxygenase activity 15/2571 93/18639 0.161290322580645 1.16930778785712 0.297834235965699 0.935325479325537 GO:0051087 protein-folding chaperone binding 21/2571 134/18639 0.156716417910448 1.13614831327609 0.298398816215132 0.935325479325537 GO:0005525 GTP binding 56/2571 378/18639 0.148148148148148 1.07403085699468 0.301809835423206 0.935325479325537 GO:0004705 JUN kinase activity 3/2571 14/18639 0.214285714285714 1.55350891815303 0.302712040667398 0.935325479325537 GO:0005313 L-glutamate transmembrane transporter activity 3/2571 14/18639 0.214285714285714 1.55350891815303 0.302712040667398 0.935325479325537 GO:0005347 ATP transmembrane transporter activity 3/2571 14/18639 0.214285714285714 1.55350891815303 0.302712040667398 0.935325479325537 GO:0008474 palmitoyl-(protein) hydrolase activity 3/2571 14/18639 0.214285714285714 1.55350891815303 0.302712040667398 0.935325479325537 GO:0008559 ABC-type xenobiotic transporter activity 3/2571 14/18639 0.214285714285714 1.55350891815303 0.302712040667398 0.935325479325537 GO:0015386 potassium:proton antiporter activity 3/2571 14/18639 0.214285714285714 1.55350891815303 0.302712040667398 0.935325479325537 GO:0032036 myosin heavy chain binding 3/2571 14/18639 0.214285714285714 1.55350891815303 0.302712040667398 0.935325479325537 GO:0032454 histone H3K9 demethylase activity 3/2571 14/18639 0.214285714285714 1.55350891815303 0.302712040667398 0.935325479325537 GO:0098599 palmitoyl hydrolase activity 3/2571 14/18639 0.214285714285714 1.55350891815303 0.302712040667398 0.935325479325537 GO:0008083 growth factor activity 25/2571 162/18639 0.154320987654321 1.1187821427028 0.303858148628047 0.935325479325537 GO:0034212 protein N-acetyltransferase activity 9/2571 53/18639 0.169811320754717 1.23108253891372 0.304598073420295 0.935325479325537 GO:0030414 peptidase inhibitor activity 26/2571 169/18639 0.153846153846154 1.11533973610986 0.304865837705459 0.935325479325537 GO:0015108 chloride transmembrane transporter activity 19/2571 121/18639 0.15702479338843 1.13838394553362 0.307586672373431 0.935325479325537 GO:0015144 carbohydrate transmembrane transporter activity 7/2571 40/18639 0.175 1.26869894982497 0.310435768295968 0.935325479325537 GO:0050997 quaternary ammonium group binding 7/2571 40/18639 0.175 1.26869894982497 0.310435768295968 0.935325479325537 GO:0061791 GTPase motor activity 7/2571 40/18639 0.175 1.26869894982497 0.310435768295968 0.935325479325537 GO:1990606 membrane scission GTPase motor activity 7/2571 40/18639 0.175 1.26869894982497 0.310435768295968 0.935325479325537 GO:0004714 transmembrane receptor protein tyrosine kinase activity 10/2571 60/18639 0.166666666666667 1.20828471411902 0.310622366057324 0.935325479325537 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 10/2571 60/18639 0.166666666666667 1.20828471411902 0.310622366057324 0.935325479325537 GO:0031625 ubiquitin protein ligase binding 45/2571 302/18639 0.149006622516556 1.08025454573555 0.310877088705605 0.935325479325537 GO:0004364 glutathione transferase activity 5/2571 27/18639 0.185185185185185 1.34253857124336 0.312919774937167 0.935325479325537 GO:0005385 zinc ion transmembrane transporter activity 5/2571 27/18639 0.185185185185185 1.34253857124336 0.312919774937167 0.935325479325537 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 5/2571 27/18639 0.185185185185185 1.34253857124336 0.312919774937167 0.935325479325537 GO:0035401 histone H3Y41 kinase activity 18/2571 115/18639 0.156521739130435 1.13473694891178 0.319233871306137 0.935325479325537 GO:0140801 histone H2AXY142 kinase activity 18/2571 115/18639 0.156521739130435 1.13473694891178 0.319233871306137 0.935325479325537 GO:0015101 organic cation transmembrane transporter activity 13/2571 81/18639 0.160493827160494 1.16353342841091 0.322828732711153 0.935325479325537 GO:0030971 receptor tyrosine kinase binding 13/2571 81/18639 0.160493827160494 1.16353342841091 0.322828732711153 0.935325479325537 GO:0002020 protease binding 21/2571 136/18639 0.154411764705882 1.11944024984556 0.323374385259683 0.935325479325537 GO:0019838 growth factor binding 21/2571 136/18639 0.154411764705882 1.11944024984556 0.323374385259683 0.935325479325537 GO:0140789 histone phosphatase activity 21/2571 136/18639 0.154411764705882 1.11944024984556 0.323374385259683 0.935325479325537 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 9/2571 54/18639 0.166666666666667 1.20828471411902 0.324757381047402 0.935325479325537 GO:0015035 protein-disulfide reductase activity 6/2571 34/18639 0.176470588235294 1.27936028553779 0.325228177549538 0.935325479325537 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 6/2571 34/18639 0.176470588235294 1.27936028553779 0.325228177549538 0.935325479325537 GO:0004197 cysteine-type endopeptidase activity 14/2571 88/18639 0.159090909090909 1.15336268165906 0.3256062728262 0.935325479325537 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 4/2571 21/18639 0.19047619047619 1.38089681613602 0.32739158233912 0.935325479325537 GO:0008373 sialyltransferase activity 4/2571 21/18639 0.19047619047619 1.38089681613602 0.32739158233912 0.935325479325537 GO:0009931 calcium-dependent protein serine/threonine kinase activity 4/2571 21/18639 0.19047619047619 1.38089681613602 0.32739158233912 0.935325479325537 GO:0070182 DNA polymerase binding 4/2571 21/18639 0.19047619047619 1.38089681613602 0.32739158233912 0.935325479325537 GO:0072542 protein phosphatase activator activity 4/2571 21/18639 0.19047619047619 1.38089681613602 0.32739158233912 0.935325479325537 GO:0140312 cargo adaptor activity 4/2571 21/18639 0.19047619047619 1.38089681613602 0.32739158233912 0.935325479325537 GO:1904047 S-adenosyl-L-methionine binding 4/2571 21/18639 0.19047619047619 1.38089681613602 0.32739158233912 0.935325479325537 GO:0005319 lipid transporter activity 27/2571 178/18639 0.151685393258427 1.09967485217574 0.32769380193553 0.935325479325537 GO:0019905 syntaxin binding 10/2571 61/18639 0.163934426229508 1.18847676798592 0.3296611339221 0.935325479325537 GO:0008238 exopeptidase activity 16/2571 102/18639 0.156862745098039 1.13720914270025 0.329915201462759 0.935325479325537 GO:0003712 transcription coregulator activity 72/2571 495/18639 0.145454545454545 1.05450302323114 0.330746631461586 0.935325479325537 GO:0016922 nuclear receptor binding 21/2571 137/18639 0.153284671532847 1.11126915313136 0.336073650009908 0.935325479325537 GO:0140693 molecular condensate scaffold activity 8/2571 48/18639 0.166666666666667 1.20828471411902 0.340308662624733 0.935325479325537 GO:0036408 histone H3K14 acetyltransferase activity 5/2571 28/18639 0.178571428571429 1.29459076512752 0.341783783786403 0.935325479325537 GO:0051119 sugar transmembrane transporter activity 5/2571 28/18639 0.178571428571429 1.29459076512752 0.341783783786403 0.935325479325537 GO:0141052 histone H3 demethylase activity 5/2571 28/18639 0.178571428571429 1.29459076512752 0.341783783786403 0.935325479325537 GO:0004467 long-chain fatty acid-CoA ligase activity 3/2571 15/18639 0.2 1.44994165694282 0.342956519399877 0.935325479325537 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 3/2571 15/18639 0.2 1.44994165694282 0.342956519399877 0.935325479325537 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 3/2571 15/18639 0.2 1.44994165694282 0.342956519399877 0.935325479325537 GO:0008242 omega peptidase activity 3/2571 15/18639 0.2 1.44994165694282 0.342956519399877 0.935325479325537 GO:0015116 sulfate transmembrane transporter activity 3/2571 15/18639 0.2 1.44994165694282 0.342956519399877 0.935325479325537 GO:0015556 C4-dicarboxylate transmembrane transporter activity 3/2571 15/18639 0.2 1.44994165694282 0.342956519399877 0.935325479325537 GO:0015929 hexosaminidase activity 3/2571 15/18639 0.2 1.44994165694282 0.342956519399877 0.935325479325537 GO:0016846 carbon-sulfur lyase activity 3/2571 15/18639 0.2 1.44994165694282 0.342956519399877 0.935325479325537 GO:0140161 monocarboxylate:sodium symporter activity 3/2571 15/18639 0.2 1.44994165694282 0.342956519399877 0.935325479325537 GO:0004896 cytokine receptor activity 15/2571 96/18639 0.15625 1.13276691948658 0.343263347636651 0.935325479325537 GO:0004722 protein serine/threonine phosphatase activity 16/2571 103/18639 0.155339805825243 1.12616827723714 0.34472000606478 0.935325479325537 GO:0008374 O-acyltransferase activity 9/2571 55/18639 0.163636363636364 1.18631590113504 0.345160323637726 0.935325479325537 GO:0031072 heat shock protein binding 20/2571 131/18639 0.152671755725191 1.10682569232277 0.348373188250465 0.935325479325537 GO:0008194 UDP-glycosyltransferase activity 22/2571 145/18639 0.151724137931034 1.09995573974973 0.349300495595301 0.935325479325537 GO:0061631 ubiquitin conjugating enzyme activity 6/2571 35/18639 0.171428571428571 1.24280713452242 0.35114102431562 0.935325479325537 GO:0004402 histone acetyltransferase activity 7/2571 42/18639 0.166666666666667 1.20828471411902 0.35762194568228 0.935325479325537 GO:0004520 DNA endonuclease activity 7/2571 42/18639 0.166666666666667 1.20828471411902 0.35762194568228 0.935325479325537 GO:0008307 structural constituent of muscle 7/2571 42/18639 0.166666666666667 1.20828471411902 0.35762194568228 0.935325479325537 GO:0019894 kinesin binding 7/2571 42/18639 0.166666666666667 1.20828471411902 0.35762194568228 0.935325479325537 GO:0042056 chemoattractant activity 7/2571 42/18639 0.166666666666667 1.20828471411902 0.35762194568228 0.935325479325537 GO:0051879 Hsp90 protein binding 7/2571 42/18639 0.166666666666667 1.20828471411902 0.35762194568228 0.935325479325537 GO:0004518 nuclease activity 31/2571 209/18639 0.148325358851675 1.07531558290018 0.360140834302401 0.935325479325537 GO:0008093 cytoskeletal anchor activity 4/2571 22/18639 0.181818181818182 1.31812877903893 0.360696546520442 0.935325479325537 GO:0008970 phospholipase A1 activity 4/2571 22/18639 0.181818181818182 1.31812877903893 0.360696546520442 0.935325479325537 GO:0015377 chloride:monoatomic cation symporter activity 4/2571 22/18639 0.181818181818182 1.31812877903893 0.360696546520442 0.935325479325537 GO:0061133 endopeptidase activator activity 4/2571 22/18639 0.181818181818182 1.31812877903893 0.360696546520442 0.935325479325537 GO:0140035 ubiquitin-like protein reader activity 4/2571 22/18639 0.181818181818182 1.31812877903893 0.360696546520442 0.935325479325537 GO:0170055 lipid transmembrane transporter activity 9/2571 56/18639 0.160714285714286 1.16513168861477 0.365744579414852 0.935325479325537 GO:0097110 scaffold protein binding 11/2571 70/18639 0.157142857142857 1.13923987331222 0.370296105942042 0.935325479325537 GO:0010484 histone H3 acetyltransferase activity 5/2571 29/18639 0.172413793103448 1.24994970426106 0.370815549533381 0.935325479325537 GO:0035250 UDP-galactosyltransferase activity 5/2571 29/18639 0.172413793103448 1.24994970426106 0.370815549533381 0.935325479325537 GO:0008170 N-methyltransferase activity 15/2571 98/18639 0.153061224489796 1.10964922725216 0.374309287879374 0.935325479325537 GO:0004033 aldo-keto reductase (NADPH) activity 6/2571 36/18639 0.166666666666667 1.20828471411902 0.37720453256625 0.935325479325537 GO:0044390 ubiquitin-like protein conjugating enzyme binding 6/2571 36/18639 0.166666666666667 1.20828471411902 0.37720453256625 0.935325479325537 GO:0140297 DNA-binding transcription factor binding 70/2571 488/18639 0.14344262295082 1.03991717198768 0.38026686663062 0.935325479325537 GO:0004712 protein serine/threonine/tyrosine kinase activity 7/2571 43/18639 0.162790697674419 1.18018506960462 0.381469503748294 0.935325479325537 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 7/2571 43/18639 0.162790697674419 1.18018506960462 0.381469503748294 0.935325479325537 GO:0000062 fatty-acyl-CoA binding 3/2571 16/18639 0.1875 1.3593203033839 0.382989563024025 0.935325479325537 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 3/2571 16/18639 0.1875 1.3593203033839 0.382989563024025 0.935325479325537 GO:0008142 oxysterol binding 3/2571 16/18639 0.1875 1.3593203033839 0.382989563024025 0.935325479325537 GO:0015378 sodium:chloride symporter activity 3/2571 16/18639 0.1875 1.3593203033839 0.382989563024025 0.935325479325537 GO:0022841 potassium ion leak channel activity 3/2571 16/18639 0.1875 1.3593203033839 0.382989563024025 0.935325479325537 GO:0022858 alanine transmembrane transporter activity 3/2571 16/18639 0.1875 1.3593203033839 0.382989563024025 0.935325479325537 GO:0043023 ribosomal large subunit binding 3/2571 16/18639 0.1875 1.3593203033839 0.382989563024025 0.935325479325537 GO:0140327 flippase activity 3/2571 16/18639 0.1875 1.3593203033839 0.382989563024025 0.935325479325537 GO:0005007 fibroblast growth factor receptor activity 8/2571 50/18639 0.16 1.15995332555426 0.384404039598544 0.935325479325537 GO:0015605 organophosphate ester transmembrane transporter activity 8/2571 50/18639 0.16 1.15995332555426 0.384404039598544 0.935325479325537 GO:0043178 alcohol binding 14/2571 92/18639 0.152173913043478 1.10321647810867 0.38998330841418 0.935325479325537 GO:0061134 peptidase regulator activity 33/2571 226/18639 0.146017699115044 1.05858572298923 0.390256328192348 0.935325479325537 GO:0000295 adenine nucleotide transmembrane transporter activity 4/2571 23/18639 0.173913043478261 1.26081883212419 0.393942851828336 0.935325479325537 GO:0017134 fibroblast growth factor binding 4/2571 23/18639 0.173913043478261 1.26081883212419 0.393942851828336 0.935325479325537 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 4/2571 23/18639 0.173913043478261 1.26081883212419 0.393942851828336 0.935325479325537 GO:0140102 catalytic activity, acting on a rRNA 4/2571 23/18639 0.173913043478261 1.26081883212419 0.393942851828336 0.935325479325537 GO:0032452 histone demethylase activity 5/2571 30/18639 0.166666666666667 1.20828471411902 0.39984893768962 0.935325479325537 GO:0043995 histone H4K5 acetyltransferase activity 5/2571 30/18639 0.166666666666667 1.20828471411902 0.39984893768962 0.935325479325537 GO:0043996 histone H4K8 acetyltransferase activity 5/2571 30/18639 0.166666666666667 1.20828471411902 0.39984893768962 0.935325479325537 GO:0043997 histone H4K12 acetyltransferase activity 5/2571 30/18639 0.166666666666667 1.20828471411902 0.39984893768962 0.935325479325537 GO:0070001 aspartic-type peptidase activity 6/2571 37/18639 0.162162162162162 1.17562837049418 0.403298547287515 0.935325479325537 GO:0004540 RNA nuclease activity 18/2571 121/18639 0.148760330578512 1.07846900103185 0.403567361077439 0.935325479325537 GO:0051219 phosphoprotein binding 14/2571 93/18639 0.150537634408602 1.09135393533331 0.406313523784797 0.935325479325537 GO:0005021 vascular endothelial growth factor receptor activity 8/2571 51/18639 0.156862745098039 1.13720914270025 0.406570263460957 0.935325479325537 GO:0005030 neurotrophin receptor activity 8/2571 51/18639 0.156862745098039 1.13720914270025 0.406570263460957 0.935325479325537 GO:0120013 lipid transfer activity 10/2571 65/18639 0.153846153846154 1.11533973610986 0.40746402018602 0.935325479325537 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 50/2571 349/18639 0.143266475644699 1.03864015540317 0.408869686638231 0.935325479325537 GO:0001094 TFIID-class transcription factor complex binding 2/2571 10/18639 0.2 1.44994165694282 0.410668173724739 0.935325479325537 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 2/2571 10/18639 0.2 1.44994165694282 0.410668173724739 0.935325479325537 GO:0004090 carbonyl reductase (NADPH) activity 2/2571 10/18639 0.2 1.44994165694282 0.410668173724739 0.935325479325537 GO:0005337 nucleoside transmembrane transporter activity 2/2571 10/18639 0.2 1.44994165694282 0.410668173724739 0.935325479325537 GO:0008140 cAMP response element binding protein binding 2/2571 10/18639 0.2 1.44994165694282 0.410668173724739 0.935325479325537 GO:0008239 dipeptidyl-peptidase activity 2/2571 10/18639 0.2 1.44994165694282 0.410668173724739 0.935325479325537 GO:0015187 glycine transmembrane transporter activity 2/2571 10/18639 0.2 1.44994165694282 0.410668173724739 0.935325479325537 GO:0016303 1-phosphatidylinositol-3-kinase activity 2/2571 10/18639 0.2 1.44994165694282 0.410668173724739 0.935325479325537 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 2/2571 10/18639 0.2 1.44994165694282 0.410668173724739 0.935325479325537 GO:0019531 oxalate transmembrane transporter activity 2/2571 10/18639 0.2 1.44994165694282 0.410668173724739 0.935325479325537 GO:0031419 cobalamin binding 2/2571 10/18639 0.2 1.44994165694282 0.410668173724739 0.935325479325537 GO:0031957 very long-chain fatty acid-CoA ligase activity 2/2571 10/18639 0.2 1.44994165694282 0.410668173724739 0.935325479325537 GO:0032052 bile acid binding 2/2571 10/18639 0.2 1.44994165694282 0.410668173724739 0.935325479325537 GO:0033204 ribonuclease P RNA binding 2/2571 10/18639 0.2 1.44994165694282 0.410668173724739 0.935325479325537 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 2/2571 10/18639 0.2 1.44994165694282 0.410668173724739 0.935325479325537 GO:0035374 chondroitin sulfate binding 2/2571 10/18639 0.2 1.44994165694282 0.410668173724739 0.935325479325537 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 2/2571 10/18639 0.2 1.44994165694282 0.410668173724739 0.935325479325537 GO:0070513 death domain binding 2/2571 10/18639 0.2 1.44994165694282 0.410668173724739 0.935325479325537 GO:0070739 protein-glutamic acid ligase activity 2/2571 10/18639 0.2 1.44994165694282 0.410668173724739 0.935325479325537 GO:0070740 tubulin-glutamic acid ligase activity 2/2571 10/18639 0.2 1.44994165694282 0.410668173724739 0.935325479325537 GO:0071723 lipopeptide binding 2/2571 10/18639 0.2 1.44994165694282 0.410668173724739 0.935325479325537 GO:0097177 mitochondrial ribosome binding 2/2571 10/18639 0.2 1.44994165694282 0.410668173724739 0.935325479325537 GO:0098505 G-rich strand telomeric DNA binding 2/2571 10/18639 0.2 1.44994165694282 0.410668173724739 0.935325479325537 GO:0140135 mechanosensitive monoatomic cation channel activity 2/2571 10/18639 0.2 1.44994165694282 0.410668173724739 0.935325479325537 GO:0141109 transporter activator activity 2/2571 10/18639 0.2 1.44994165694282 0.410668173724739 0.935325479325537 GO:1905394 retromer complex binding 2/2571 10/18639 0.2 1.44994165694282 0.410668173724739 0.935325479325537 GO:0019001 guanyl nucleotide binding 57/2571 400/18639 0.1425 1.03308343057176 0.416633848994334 0.935325479325537 GO:0032561 guanyl ribonucleotide binding 57/2571 400/18639 0.1425 1.03308343057176 0.416633848994334 0.935325479325537 GO:0017124 SH3 domain binding 17/2571 115/18639 0.147826086956522 1.07169600730557 0.419094504694186 0.935325479325537 GO:0004029 aldehyde dehydrogenase (NAD+) activity 3/2571 17/18639 0.176470588235294 1.27936028553779 0.422432679623972 0.935325479325537 GO:0004550 nucleoside diphosphate kinase activity 3/2571 17/18639 0.176470588235294 1.27936028553779 0.422432679623972 0.935325479325537 GO:0008484 sulfuric ester hydrolase activity 3/2571 17/18639 0.176470588235294 1.27936028553779 0.422432679623972 0.935325479325537 GO:0030169 low-density lipoprotein particle binding 3/2571 17/18639 0.176470588235294 1.27936028553779 0.422432679623972 0.935325479325537 GO:0032183 SUMO binding 3/2571 17/18639 0.176470588235294 1.27936028553779 0.422432679623972 0.935325479325537 GO:0032977 membrane insertase activity 3/2571 17/18639 0.176470588235294 1.27936028553779 0.422432679623972 0.935325479325537 GO:0051787 misfolded protein binding 3/2571 17/18639 0.176470588235294 1.27936028553779 0.422432679623972 0.935325479325537 GO:1901567 fatty acid derivative binding 3/2571 17/18639 0.176470588235294 1.27936028553779 0.422432679623972 0.935325479325537 GO:0044389 ubiquitin-like protein ligase binding 46/2571 322/18639 0.142857142857143 1.03567261210202 0.422642504027797 0.935325479325537 GO:0001091 RNA polymerase II general transcription initiation factor binding 4/2571 24/18639 0.166666666666667 1.20828471411902 0.426904038279204 0.935325479325537 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 4/2571 24/18639 0.166666666666667 1.20828471411902 0.426904038279204 0.935325479325537 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 4/2571 24/18639 0.166666666666667 1.20828471411902 0.426904038279204 0.935325479325537 GO:0004806 triacylglycerol lipase activity 4/2571 24/18639 0.166666666666667 1.20828471411902 0.426904038279204 0.935325479325537 GO:0015149 hexose transmembrane transporter activity 4/2571 24/18639 0.166666666666667 1.20828471411902 0.426904038279204 0.935325479325537 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 4/2571 24/18639 0.166666666666667 1.20828471411902 0.426904038279204 0.935325479325537 GO:0055056 D-glucose transmembrane transporter activity 4/2571 24/18639 0.166666666666667 1.20828471411902 0.426904038279204 0.935325479325537 GO:0004879 nuclear receptor activity 9/2571 59/18639 0.152542372881356 1.10588770444792 0.427977197413967 0.935325479325537 GO:0005310 dicarboxylic acid transmembrane transporter activity 5/2571 31/18639 0.161290322580645 1.16930778785712 0.428729668241249 0.935325479325537 GO:0072349 modified amino acid transmembrane transporter activity 5/2571 31/18639 0.161290322580645 1.16930778785712 0.428729668241249 0.935325479325537 GO:0140457 protein demethylase activity 5/2571 31/18639 0.161290322580645 1.16930778785712 0.428729668241249 0.935325479325537 GO:0004715 non-membrane spanning protein tyrosine kinase activity 7/2571 45/18639 0.155555555555556 1.12773239984442 0.429214265827293 0.935325479325537 GO:0042162 telomeric DNA binding 6/2571 38/18639 0.157894736842105 1.14469078179697 0.429309492718688 0.935325479325537 GO:0043531 ADP binding 6/2571 38/18639 0.157894736842105 1.14469078179697 0.429309492718688 0.935325479325537 GO:0031406 carboxylic acid binding 27/2571 187/18639 0.144385026737968 1.04674932453092 0.430519423756337 0.935325479325537 GO:0015171 amino acid transmembrane transporter activity 15/2571 102/18639 0.147058823529412 1.06613357128149 0.437284787889857 0.935325479325537 GO:0046906 tetrapyrrole binding 22/2571 152/18639 0.144736842105263 1.04929988331389 0.438946826026747 0.935325479325537 GO:0048029 monosaccharide binding 11/2571 74/18639 0.148648648648649 1.07765933961967 0.444665258830305 0.935325479325537 GO:0008173 RNA methyltransferase activity 10/2571 67/18639 0.149253731343284 1.0820460126439 0.446646391956218 0.935325479325537 GO:0016500 protein-hormone receptor activity 10/2571 67/18639 0.149253731343284 1.0820460126439 0.446646391956218 0.935325479325537 GO:0098531 ligand-modulated transcription factor activity 9/2571 60/18639 0.15 1.08745624270712 0.448686873535728 0.935325479325537 GO:0005003 ephrin receptor activity 8/2571 53/18639 0.150943396226415 1.09429559014553 0.450786482143439 0.935325479325537 GO:0005005 transmembrane-ephrin receptor activity 8/2571 53/18639 0.150943396226415 1.09429559014553 0.450786482143439 0.935325479325537 GO:0005246 calcium channel regulator activity 8/2571 53/18639 0.150943396226415 1.09429559014553 0.450786482143439 0.935325479325537 GO:0038064 collagen receptor activity 8/2571 53/18639 0.150943396226415 1.09429559014553 0.450786482143439 0.935325479325537 GO:0051018 protein kinase A binding 8/2571 53/18639 0.150943396226415 1.09429559014553 0.450786482143439 0.935325479325537 GO:0030276 clathrin binding 7/2571 46/18639 0.152173913043478 1.10321647810867 0.452940069200274 0.935325479325537 GO:0043177 organic acid binding 27/2571 189/18639 0.142857142857143 1.03567261210202 0.453804364097606 0.935325479325537 GO:0016776 phosphotransferase activity, phosphate group as acceptor 6/2571 39/18639 0.153846153846154 1.11533973610986 0.455131235432916 0.935325479325537 GO:0015106 bicarbonate transmembrane transporter activity 5/2571 32/18639 0.15625 1.13276691948658 0.457316427151765 0.935325479325537 GO:0043425 bHLH transcription factor binding 5/2571 32/18639 0.15625 1.13276691948658 0.457316427151765 0.935325479325537 GO:0071813 lipoprotein particle binding 5/2571 32/18639 0.15625 1.13276691948658 0.457316427151765 0.935325479325537 GO:0071814 protein-lipid complex binding 5/2571 32/18639 0.15625 1.13276691948658 0.457316427151765 0.935325479325537 GO:0000030 mannosyltransferase activity 4/2571 25/18639 0.16 1.15995332555426 0.459379299867847 0.935325479325537 GO:0004709 MAP kinase kinase kinase activity 4/2571 25/18639 0.16 1.15995332555426 0.459379299867847 0.935325479325537 GO:0005251 delayed rectifier potassium channel activity 4/2571 25/18639 0.16 1.15995332555426 0.459379299867847 0.935325479325537 GO:0015296 monoatomic anion:monoatomic cation symporter activity 4/2571 25/18639 0.16 1.15995332555426 0.459379299867847 0.935325479325537 GO:0015645 fatty acid ligase activity 4/2571 25/18639 0.16 1.15995332555426 0.459379299867847 0.935325479325537 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 4/2571 25/18639 0.16 1.15995332555426 0.459379299867847 0.935325479325537 GO:0017056 structural constituent of nuclear pore 4/2571 25/18639 0.16 1.15995332555426 0.459379299867847 0.935325479325537 GO:0019211 phosphatase activator activity 4/2571 25/18639 0.16 1.15995332555426 0.459379299867847 0.935325479325537 GO:0019706 protein-cysteine S-palmitoyltransferase activity 4/2571 25/18639 0.16 1.15995332555426 0.459379299867847 0.935325479325537 GO:0019707 protein-cysteine S-acyltransferase activity 4/2571 25/18639 0.16 1.15995332555426 0.459379299867847 0.935325479325537 GO:0120515 fatty acid-CoA ligase activity 4/2571 25/18639 0.16 1.15995332555426 0.459379299867847 0.935325479325537 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 2/2571 11/18639 0.181818181818182 1.31812877903893 0.4607121114264 0.935325479325537 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 2/2571 11/18639 0.181818181818182 1.31812877903893 0.4607121114264 0.935325479325537 GO:0004016 adenylate cyclase activity 2/2571 11/18639 0.181818181818182 1.31812877903893 0.4607121114264 0.935325479325537 GO:0004143 ATP-dependent diacylglycerol kinase activity 2/2571 11/18639 0.181818181818182 1.31812877903893 0.4607121114264 0.935325479325537 GO:0005114 type II transforming growth factor beta receptor binding 2/2571 11/18639 0.181818181818182 1.31812877903893 0.4607121114264 0.935325479325537 GO:0005536 D-glucose binding 2/2571 11/18639 0.181818181818182 1.31812877903893 0.4607121114264 0.935325479325537 GO:0008271 secondary active sulfate transmembrane transporter activity 2/2571 11/18639 0.181818181818182 1.31812877903893 0.4607121114264 0.935325479325537 GO:0008503 benzodiazepine receptor activity 2/2571 11/18639 0.181818181818182 1.31812877903893 0.4607121114264 0.935325479325537 GO:0008526 phosphatidylinositol transfer activity 2/2571 11/18639 0.181818181818182 1.31812877903893 0.4607121114264 0.935325479325537 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 2/2571 11/18639 0.181818181818182 1.31812877903893 0.4607121114264 0.935325479325537 GO:0016176 superoxide-generating NADPH oxidase activator activity 2/2571 11/18639 0.181818181818182 1.31812877903893 0.4607121114264 0.935325479325537 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 2/2571 11/18639 0.181818181818182 1.31812877903893 0.4607121114264 0.935325479325537 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 2/2571 11/18639 0.181818181818182 1.31812877903893 0.4607121114264 0.935325479325537 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 2/2571 11/18639 0.181818181818182 1.31812877903893 0.4607121114264 0.935325479325537 GO:0019215 intermediate filament binding 2/2571 11/18639 0.181818181818182 1.31812877903893 0.4607121114264 0.935325479325537 GO:0034056 estrogen response element binding 2/2571 11/18639 0.181818181818182 1.31812877903893 0.4607121114264 0.935325479325537 GO:0034511 U3 snoRNA binding 2/2571 11/18639 0.181818181818182 1.31812877903893 0.4607121114264 0.935325479325537 GO:0035252 UDP-xylosyltransferase activity 2/2571 11/18639 0.181818181818182 1.31812877903893 0.4607121114264 0.935325479325537 GO:0042285 xylosyltransferase activity 2/2571 11/18639 0.181818181818182 1.31812877903893 0.4607121114264 0.935325479325537 GO:0048407 platelet-derived growth factor binding 2/2571 11/18639 0.181818181818182 1.31812877903893 0.4607121114264 0.935325479325537 GO:0050998 nitric-oxide synthase binding 2/2571 11/18639 0.181818181818182 1.31812877903893 0.4607121114264 0.935325479325537 GO:0097493 structural molecule activity conferring elasticity 2/2571 11/18639 0.181818181818182 1.31812877903893 0.4607121114264 0.935325479325537 GO:0140031 phosphorylation-dependent protein binding 2/2571 11/18639 0.181818181818182 1.31812877903893 0.4607121114264 0.935325479325537 GO:0140537 transcription regulator activator activity 2/2571 11/18639 0.181818181818182 1.31812877903893 0.4607121114264 0.935325479325537 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 3/2571 18/18639 0.166666666666667 1.20828471411902 0.460970382327671 0.935325479325537 GO:0015373 monoatomic anion:sodium symporter activity 3/2571 18/18639 0.166666666666667 1.20828471411902 0.460970382327671 0.935325479325537 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 3/2571 18/18639 0.166666666666667 1.20828471411902 0.460970382327671 0.935325479325537 GO:0035615 clathrin adaptor activity 3/2571 18/18639 0.166666666666667 1.20828471411902 0.460970382327671 0.935325479325537 GO:0070628 proteasome binding 3/2571 18/18639 0.166666666666667 1.20828471411902 0.460970382327671 0.935325479325537 GO:0003714 transcription corepressor activity 29/2571 204/18639 0.142156862745098 1.03059578557211 0.461086232386261 0.935325479325537 GO:0044183 protein folding chaperone 11/2571 75/18639 0.146666666666667 1.06329054842474 0.463210580020759 0.938148010168625 GO:0005548 phospholipid transporter activity 10/2571 68/18639 0.147058823529412 1.06613357128149 0.46613960587489 0.942588776492668 GO:0019210 kinase inhibitor activity 13/2571 90/18639 0.144444444444444 1.04718008556982 0.474807743423545 0.952760308414307 GO:0043495 protein-membrane adaptor activity 7/2571 47/18639 0.148936170212766 1.07974378708508 0.4764621494243 0.952760308414307 GO:0140359 ABC-type transporter activity 7/2571 47/18639 0.148936170212766 1.07974378708508 0.4764621494243 0.952760308414307 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 12/2571 83/18639 0.144578313253012 1.04815059538035 0.478108507903049 0.952760308414307 GO:0005254 chloride channel activity 12/2571 83/18639 0.144578313253012 1.04815059538035 0.478108507903049 0.952760308414307 GO:0030165 PDZ domain binding 12/2571 83/18639 0.144578313253012 1.04815059538035 0.478108507903049 0.952760308414307 GO:0004532 RNA exonuclease activity 6/2571 40/18639 0.15 1.08745624270712 0.480665729633554 0.952760308414307 GO:0032451 demethylase activity 6/2571 40/18639 0.15 1.08745624270712 0.480665729633554 0.952760308414307 GO:0071855 neuropeptide receptor binding 6/2571 40/18639 0.15 1.08745624270712 0.480665729633554 0.952760308414307 GO:0140662 ATP-dependent protein folding chaperone 6/2571 40/18639 0.15 1.08745624270712 0.480665729633554 0.952760308414307 GO:0043022 ribosome binding 16/2571 112/18639 0.142857142857143 1.03567261210202 0.48123015853863 0.952760308414307 GO:0017022 myosin binding 11/2571 76/18639 0.144736842105263 1.04929988331389 0.481658153508651 0.952760308414307 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 4/2571 26/18639 0.153846153846154 1.11533973610986 0.491193728567223 0.952760308414307 GO:0008198 ferrous iron binding 4/2571 26/18639 0.153846153846154 1.11533973610986 0.491193728567223 0.952760308414307 GO:0015145 monosaccharide transmembrane transporter activity 4/2571 26/18639 0.153846153846154 1.11533973610986 0.491193728567223 0.952760308414307 GO:0015216 purine nucleotide transmembrane transporter activity 4/2571 26/18639 0.153846153846154 1.11533973610986 0.491193728567223 0.952760308414307 GO:0030247 polysaccharide binding 4/2571 26/18639 0.153846153846154 1.11533973610986 0.491193728567223 0.952760308414307 GO:0050681 nuclear androgen receptor binding 4/2571 26/18639 0.153846153846154 1.11533973610986 0.491193728567223 0.952760308414307 GO:0050750 low-density lipoprotein particle receptor binding 4/2571 26/18639 0.153846153846154 1.11533973610986 0.491193728567223 0.952760308414307 GO:0097602 cullin family protein binding 4/2571 26/18639 0.153846153846154 1.11533973610986 0.491193728567223 0.952760308414307 GO:0120014 phospholipid transfer activity 4/2571 26/18639 0.153846153846154 1.11533973610986 0.491193728567223 0.952760308414307 GO:0004860 protein kinase inhibitor activity 12/2571 84/18639 0.142857142857143 1.03567261210202 0.495644226595186 0.952760308414307 GO:0020037 heme binding 20/2571 142/18639 0.140845070422535 1.0210856739034 0.496809106189585 0.952760308414307 GO:0005346 purine ribonucleotide transmembrane transporter activity 3/2571 19/18639 0.157894736842105 1.14469078179697 0.498346272945269 0.952760308414307 GO:0005520 insulin-like growth factor binding 3/2571 19/18639 0.157894736842105 1.14469078179697 0.498346272945269 0.952760308414307 GO:0008574 plus-end-directed microtubule motor activity 3/2571 19/18639 0.157894736842105 1.14469078179697 0.498346272945269 0.952760308414307 GO:0022840 leak channel activity 3/2571 19/18639 0.157894736842105 1.14469078179697 0.498346272945269 0.952760308414307 GO:0022842 narrow pore channel activity 3/2571 19/18639 0.157894736842105 1.14469078179697 0.498346272945269 0.952760308414307 GO:0030506 ankyrin binding 3/2571 19/18639 0.157894736842105 1.14469078179697 0.498346272945269 0.952760308414307 GO:0031420 alkali metal ion binding 3/2571 19/18639 0.157894736842105 1.14469078179697 0.498346272945269 0.952760308414307 GO:0097001 ceramide binding 3/2571 19/18639 0.157894736842105 1.14469078179697 0.498346272945269 0.952760308414307 GO:0120227 acyl-CoA binding 3/2571 19/18639 0.157894736842105 1.14469078179697 0.498346272945269 0.952760308414307 GO:0008013 beta-catenin binding 15/2571 106/18639 0.141509433962264 1.02590211576143 0.500086802882088 0.952760308414307 GO:0016782 transferase activity, transferring sulphur-containing groups 10/2571 70/18639 0.142857142857143 1.03567261210202 0.504710126874429 0.952760308414307 GO:0042169 SH2 domain binding 6/2571 41/18639 0.146341463414634 1.06093291971426 0.505823461924108 0.952760308414307 GO:0061650 ubiquitin-like protein conjugating enzyme activity 6/2571 41/18639 0.146341463414634 1.06093291971426 0.505823461924108 0.952760308414307 GO:0140318 protein transporter activity 6/2571 41/18639 0.146341463414634 1.06093291971426 0.505823461924108 0.952760308414307 GO:0000340 RNA 7-methylguanosine cap binding 2/2571 12/18639 0.166666666666667 1.20828471411902 0.508168690506605 0.952760308414307 GO:0004526 ribonuclease P activity 2/2571 12/18639 0.166666666666667 1.20828471411902 0.508168690506605 0.952760308414307 GO:0005247 voltage-gated chloride channel activity 2/2571 12/18639 0.166666666666667 1.20828471411902 0.508168690506605 0.952760308414307 GO:0015368 calcium:monoatomic cation antiporter activity 2/2571 12/18639 0.166666666666667 1.20828471411902 0.508168690506605 0.952760308414307 GO:0016801 hydrolase activity, acting on ether bonds 2/2571 12/18639 0.166666666666667 1.20828471411902 0.508168690506605 0.952760308414307 GO:0016803 ether hydrolase activity 2/2571 12/18639 0.166666666666667 1.20828471411902 0.508168690506605 0.952760308414307 GO:0016840 carbon-nitrogen lyase activity 2/2571 12/18639 0.166666666666667 1.20828471411902 0.508168690506605 0.952760308414307 GO:0031543 peptidyl-proline dioxygenase activity 2/2571 12/18639 0.166666666666667 1.20828471411902 0.508168690506605 0.952760308414307 GO:0070008 serine-type exopeptidase activity 2/2571 12/18639 0.166666666666667 1.20828471411902 0.508168690506605 0.952760308414307 GO:0070410 co-SMAD binding 2/2571 12/18639 0.166666666666667 1.20828471411902 0.508168690506605 0.952760308414307 GO:0070679 inositol 1,4,5 trisphosphate binding 2/2571 12/18639 0.166666666666667 1.20828471411902 0.508168690506605 0.952760308414307 GO:0097677 STAT family protein binding 2/2571 12/18639 0.166666666666667 1.20828471411902 0.508168690506605 0.952760308414307 GO:0052689 carboxylic ester hydrolase activity 13/2571 92/18639 0.141304347826087 1.02441530110091 0.508386945817947 0.952760308414307 GO:0008175 tRNA methyltransferase activity 5/2571 34/18639 0.147058823529412 1.06613357128149 0.513111464409616 0.955630528696104 GO:0008376 acetylgalactosaminyltransferase activity 5/2571 34/18639 0.147058823529412 1.06613357128149 0.513111464409616 0.955630528696104 GO:0008234 cysteine-type peptidase activity 26/2571 187/18639 0.13903743315508 1.00798083102977 0.514910237933354 0.955630528696104 GO:0001671 ATPase activator activity 4/2571 27/18639 0.148148148148148 1.07403085699468 0.522197894415928 0.955630528696104 GO:0008320 protein transmembrane transporter activity 4/2571 27/18639 0.148148148148148 1.07403085699468 0.522197894415928 0.955630528696104 GO:0016405 CoA-ligase activity 4/2571 27/18639 0.148148148148148 1.07403085699468 0.522197894415928 0.955630528696104 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 4/2571 27/18639 0.148148148148148 1.07403085699468 0.522197894415928 0.955630528696104 GO:0005004 GPI-linked ephrin receptor activity 7/2571 49/18639 0.142857142857143 1.03567261210202 0.522610445380682 0.955630528696104 GO:0005008 hepatocyte growth factor receptor activity 7/2571 49/18639 0.142857142857143 1.03567261210202 0.522610445380682 0.955630528696104 GO:0005009 insulin receptor activity 7/2571 49/18639 0.142857142857143 1.03567261210202 0.522610445380682 0.955630528696104 GO:0005011 macrophage colony-stimulating factor receptor activity 7/2571 49/18639 0.142857142857143 1.03567261210202 0.522610445380682 0.955630528696104 GO:0005018 platelet-derived growth factor alpha-receptor activity 7/2571 49/18639 0.142857142857143 1.03567261210202 0.522610445380682 0.955630528696104 GO:0005020 stem cell factor receptor activity 7/2571 49/18639 0.142857142857143 1.03567261210202 0.522610445380682 0.955630528696104 GO:0008288 boss receptor activity 7/2571 49/18639 0.142857142857143 1.03567261210202 0.522610445380682 0.955630528696104 GO:0036332 placental growth factor receptor activity 7/2571 49/18639 0.142857142857143 1.03567261210202 0.522610445380682 0.955630528696104 GO:0038062 protein tyrosine kinase collagen receptor activity 7/2571 49/18639 0.142857142857143 1.03567261210202 0.522610445380682 0.955630528696104 GO:0060175 brain-derived neurotrophic factor receptor activity 7/2571 49/18639 0.142857142857143 1.03567261210202 0.522610445380682 0.955630528696104 GO:0016298 lipase activity 18/2571 130/18639 0.138461538461538 1.00380576249888 0.531797386636968 0.971042303702309 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 3/2571 20/18639 0.15 1.08745624270712 0.534358145465898 0.972942284774324 GO:0140939 histone H4 methyltransferase activity 3/2571 20/18639 0.15 1.08745624270712 0.534358145465898 0.972942284774324 GO:0010485 histone H4 acetyltransferase activity 5/2571 35/18639 0.142857142857143 1.03567261210202 0.540106537758615 0.978676621732231 GO:0008168 methyltransferase activity 28/2571 204/18639 0.137254901960784 0.995057999862722 0.542420473491331 0.978676621732231 GO:0005518 collagen binding 10/2571 72/18639 0.138888888888889 1.00690392843252 0.542459350191334 0.978676621732231 GO:0005006 epidermal growth factor receptor activity 7/2571 50/18639 0.14 1.01495915985998 0.54510916260103 0.978676621732231 GO:0005017 platelet-derived growth factor receptor activity 7/2571 50/18639 0.14 1.01495915985998 0.54510916260103 0.978676621732231 GO:0005019 platelet-derived growth factor beta-receptor activity 7/2571 50/18639 0.14 1.01495915985998 0.54510916260103 0.978676621732231 GO:0051393 alpha-actinin binding 4/2571 28/18639 0.142857142857143 1.03567261210202 0.552266912854182 0.978676621732231 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 2/2571 13/18639 0.153846153846154 1.11533973610986 0.552799373056565 0.978676621732231 GO:0004465 lipoprotein lipase activity 2/2571 13/18639 0.153846153846154 1.11533973610986 0.552799373056565 0.978676621732231 GO:0004535 poly(A)-specific ribonuclease activity 2/2571 13/18639 0.153846153846154 1.11533973610986 0.552799373056565 0.978676621732231 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 2/2571 13/18639 0.153846153846154 1.11533973610986 0.552799373056565 0.978676621732231 GO:0005542 folic acid binding 2/2571 13/18639 0.153846153846154 1.11533973610986 0.552799373056565 0.978676621732231 GO:0015651 quaternary ammonium group transmembrane transporter activity 2/2571 13/18639 0.153846153846154 1.11533973610986 0.552799373056565 0.978676621732231 GO:0045159 myosin II binding 2/2571 13/18639 0.153846153846154 1.11533973610986 0.552799373056565 0.978676621732231 GO:0046974 histone H3K9 methyltransferase activity 2/2571 13/18639 0.153846153846154 1.11533973610986 0.552799373056565 0.978676621732231 GO:0046975 histone H3K36 methyltransferase activity 2/2571 13/18639 0.153846153846154 1.11533973610986 0.552799373056565 0.978676621732231 GO:0061459 L-arginine transmembrane transporter activity 2/2571 13/18639 0.153846153846154 1.11533973610986 0.552799373056565 0.978676621732231 GO:0070700 BMP receptor binding 2/2571 13/18639 0.153846153846154 1.11533973610986 0.552799373056565 0.978676621732231 GO:0140333 glycerophospholipid flippase activity 2/2571 13/18639 0.153846153846154 1.11533973610986 0.552799373056565 0.978676621732231 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 2/2571 13/18639 0.153846153846154 1.11533973610986 0.552799373056565 0.978676621732231 GO:1990782 protein tyrosine kinase binding 16/2571 117/18639 0.136752136752137 0.991413098764324 0.555697610487556 0.982448814121646 GO:0043539 protein serine/threonine kinase activator activity 10/2571 73/18639 0.136986301369863 0.993110723933441 0.560935343497655 0.985378281032903 GO:0004190 aspartic-type endopeptidase activity 5/2571 36/18639 0.138888888888889 1.00690392843252 0.566381054725126 0.985378281032903 GO:0004869 cysteine-type endopeptidase inhibitor activity 5/2571 36/18639 0.138888888888889 1.00690392843252 0.566381054725126 0.985378281032903 GO:0003743 translation initiation factor activity 7/2571 51/18639 0.137254901960784 0.995057999862722 0.567149442009678 0.985378281032903 GO:0005010 insulin-like growth factor receptor activity 7/2571 51/18639 0.137254901960784 0.995057999862722 0.567149442009678 0.985378281032903 GO:0016597 amino acid binding 7/2571 51/18639 0.137254901960784 0.995057999862722 0.567149442009678 0.985378281032903 GO:0009975 cyclase activity 3/2571 21/18639 0.142857142857143 1.03567261210202 0.568852572653695 0.985378281032903 GO:0015174 basic amino acid transmembrane transporter activity 3/2571 21/18639 0.142857142857143 1.03567261210202 0.568852572653695 0.985378281032903 GO:0061891 calcium ion sensor activity 3/2571 21/18639 0.142857142857143 1.03567261210202 0.568852572653695 0.985378281032903 GO:0008235 metalloexopeptidase activity 9/2571 66/18639 0.136363636363636 0.988596584279198 0.568971663700886 0.985378281032903 GO:0033192 calmodulin-dependent protein phosphatase activity 11/2571 81/18639 0.135802469135802 0.984528285578461 0.571211472286261 0.985378281032903 GO:0140791 histone H2AXS140 phosphatase activity 11/2571 81/18639 0.135802469135802 0.984528285578461 0.571211472286261 0.985378281032903 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 11/2571 81/18639 0.135802469135802 0.984528285578461 0.571211472286261 0.985378281032903 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 11/2571 81/18639 0.135802469135802 0.984528285578461 0.571211472286261 0.985378281032903 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 11/2571 81/18639 0.135802469135802 0.984528285578461 0.571211472286261 0.985378281032903 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 11/2571 81/18639 0.135802469135802 0.984528285578461 0.571211472286261 0.985378281032903 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 11/2571 81/18639 0.135802469135802 0.984528285578461 0.571211472286261 0.985378281032903 GO:1990439 MAP kinase serine/threonine phosphatase activity 11/2571 81/18639 0.135802469135802 0.984528285578461 0.571211472286261 0.985378281032903 GO:0001046 core promoter sequence-specific DNA binding 6/2571 44/18639 0.136363636363636 0.988596584279198 0.578273359860395 0.99621790123998 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 4/2571 29/18639 0.137931034482759 0.999959763408844 0.581299130985511 0.997403334666829 GO:0016417 S-acyltransferase activity 4/2571 29/18639 0.137931034482759 0.999959763408844 0.581299130985511 0.997403334666829 GO:0097472 cyclin-dependent protein kinase activity 4/2571 29/18639 0.137931034482759 0.999959763408844 0.581299130985511 0.997403334666829 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 11/2571 82/18639 0.134146341463415 0.972521843071406 0.588369621022841 0.997669328285352 GO:0033549 MAP kinase phosphatase activity 11/2571 82/18639 0.134146341463415 0.972521843071406 0.588369621022841 0.997669328285352 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 7/2571 52/18639 0.134615384615385 0.975922269096131 0.588682862973565 0.997669328285352 GO:0022829 wide pore channel activity 5/2571 37/18639 0.135135135135135 0.979690308745151 0.591862696512252 0.997669328285352 GO:0004065 arylsulfatase activity 2/2571 14/18639 0.142857142857143 1.03567261210202 0.594480595121425 0.997669328285352 GO:0005545 1-phosphatidylinositol binding 2/2571 14/18639 0.142857142857143 1.03567261210202 0.594480595121425 0.997669328285352 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 2/2571 14/18639 0.142857142857143 1.03567261210202 0.594480595121425 0.997669328285352 GO:0030983 mismatched DNA binding 2/2571 14/18639 0.142857142857143 1.03567261210202 0.594480595121425 0.997669328285352 GO:0031404 chloride ion binding 2/2571 14/18639 0.142857142857143 1.03567261210202 0.594480595121425 0.997669328285352 GO:0042813 Wnt receptor activity 2/2571 14/18639 0.142857142857143 1.03567261210202 0.594480595121425 0.997669328285352 GO:0070742 C2H2 zinc finger domain binding 2/2571 14/18639 0.142857142857143 1.03567261210202 0.594480595121425 0.997669328285352 GO:1901612 cardiolipin binding 2/2571 14/18639 0.142857142857143 1.03567261210202 0.594480595121425 0.997669328285352 GO:0008649 rRNA methyltransferase activity 3/2571 22/18639 0.136363636363636 0.988596584279198 0.601719313622103 0.997669328285352 GO:0032931 histone H3K56 acetyltransferase activity 3/2571 22/18639 0.136363636363636 0.988596584279198 0.601719313622103 0.997669328285352 GO:0043992 histone H3K9 acetyltransferase activity 3/2571 22/18639 0.136363636363636 0.988596584279198 0.601719313622103 0.997669328285352 GO:0043993 histone H3K18 acetyltransferase activity 3/2571 22/18639 0.136363636363636 0.988596584279198 0.601719313622103 0.997669328285352 GO:0043994 histone H3K23 acetyltransferase activity 3/2571 22/18639 0.136363636363636 0.988596584279198 0.601719313622103 0.997669328285352 GO:0043999 histone H2AK5 acetyltransferase activity 3/2571 22/18639 0.136363636363636 0.988596584279198 0.601719313622103 0.997669328285352 GO:0044012 histone H2AK9 acetyltransferase activity 3/2571 22/18639 0.136363636363636 0.988596584279198 0.601719313622103 0.997669328285352 GO:0044014 histone H2BK5 acetyltransferase activity 3/2571 22/18639 0.136363636363636 0.988596584279198 0.601719313622103 0.997669328285352 GO:0044015 histone H2BK12 acetyltransferase activity 3/2571 22/18639 0.136363636363636 0.988596584279198 0.601719313622103 0.997669328285352 GO:0044016 histone H3K4 acetyltransferase activity 3/2571 22/18639 0.136363636363636 0.988596584279198 0.601719313622103 0.997669328285352 GO:0044017 histone H3K27 acetyltransferase activity 3/2571 22/18639 0.136363636363636 0.988596584279198 0.601719313622103 0.997669328285352 GO:0044018 histone H3K36 acetyltransferase activity 3/2571 22/18639 0.136363636363636 0.988596584279198 0.601719313622103 0.997669328285352 GO:0140784 metal ion sensor activity 3/2571 22/18639 0.136363636363636 0.988596584279198 0.601719313622103 0.997669328285352 GO:0140908 histone H3K122 acetyltransferase activity 3/2571 22/18639 0.136363636363636 0.988596584279198 0.601719313622103 0.997669328285352 GO:0016853 isomerase activity 24/2571 180/18639 0.133333333333333 0.966627771295216 0.604330247591378 1 GO:1990841 promoter-specific chromatin binding 9/2571 68/18639 0.132352941176471 0.959520214153339 0.606534901717516 1 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 4/2571 30/18639 0.133333333333333 0.966627771295216 0.609214545338726 1 GO:0015215 nucleotide transmembrane transporter activity 4/2571 30/18639 0.133333333333333 0.966627771295216 0.609214545338726 1 GO:0016769 transferase activity, transferring nitrogenous groups 4/2571 30/18639 0.133333333333333 0.966627771295216 0.609214545338726 1 GO:0031210 phosphatidylcholine binding 4/2571 30/18639 0.133333333333333 0.966627771295216 0.609214545338726 1 GO:0044325 transmembrane transporter binding 18/2571 136/18639 0.132352941176471 0.959520214153339 0.612920592524194 1 GO:0051536 iron-sulfur cluster binding 10/2571 76/18639 0.131578947368421 0.953908984830805 0.614397823192796 1 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 24/2571 181/18639 0.132596685082873 0.961287286370933 0.615683390628627 1 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 5/2571 38/18639 0.131578947368421 0.953908984830805 0.616491969814307 1 GO:0042887 amide transmembrane transporter activity 5/2571 38/18639 0.131578947368421 0.953908984830805 0.616491969814307 1 GO:0017018 myosin phosphatase activity 11/2571 84/18639 0.130952380952381 0.949366561093516 0.621725743722497 1 GO:0003713 transcription coactivator activity 34/2571 256/18639 0.1328125 0.962851881563594 0.622204306748796 1 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 6/2571 46/18639 0.130434782608696 0.945614124093146 0.623445347019115 1 GO:0016279 protein-lysine N-methyltransferase activity 9/2571 69/18639 0.130434782608696 0.945614124093146 0.624688918392529 1 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 22/2571 167/18639 0.131736526946108 0.955051390800662 0.626305125499348 1 GO:0051540 metal cluster binding 10/2571 77/18639 0.12987012987013 0.941520556456379 0.631476413924043 1 GO:0004022 alcohol dehydrogenase (NAD+) activity 3/2571 23/18639 0.130434782608696 0.945614124093146 0.632885782891168 1 GO:0044013 histone H2B acetyltransferase activity 3/2571 23/18639 0.130434782608696 0.945614124093146 0.632885782891168 1 GO:0004865 protein serine/threonine phosphatase inhibitor activity 2/2571 15/18639 0.133333333333333 0.966627771295216 0.633176606770895 1 GO:0004953 icosanoid receptor activity 2/2571 15/18639 0.133333333333333 0.966627771295216 0.633176606770895 1 GO:0008252 nucleotidase activity 2/2571 15/18639 0.133333333333333 0.966627771295216 0.633176606770895 1 GO:0010181 FMN binding 2/2571 15/18639 0.133333333333333 0.966627771295216 0.633176606770895 1 GO:0050700 CARD domain binding 2/2571 15/18639 0.133333333333333 0.966627771295216 0.633176606770895 1 GO:0050780 dopamine receptor binding 2/2571 15/18639 0.133333333333333 0.966627771295216 0.633176606770895 1 GO:0051371 muscle alpha-actinin binding 2/2571 15/18639 0.133333333333333 0.966627771295216 0.633176606770895 1 GO:0016878 acid-thiol ligase activity 4/2571 31/18639 0.129032258064516 0.935446230285693 0.635953045649462 1 GO:0017147 Wnt-protein binding 4/2571 31/18639 0.129032258064516 0.935446230285693 0.635953045649462 1 GO:0070325 lipoprotein particle receptor binding 4/2571 31/18639 0.129032258064516 0.935446230285693 0.635953045649462 1 GO:0016278 lysine N-methyltransferase activity 9/2571 70/18639 0.128571428571429 0.932105350891815 0.642390707305036 1 GO:0019199 transmembrane receptor protein kinase activity 10/2571 78/18639 0.128205128205128 0.929449780091554 0.64814720468599 1 GO:0140313 molecular sequestering activity 7/2571 55/18639 0.127272727272727 0.922690145327251 0.649848279277726 1 GO:0004620 phospholipase activity 14/2571 109/18639 0.128440366972477 0.931155192532089 0.655277497148676 1 GO:0016741 transferase activity, transferring one-carbon groups 28/2571 215/18639 0.130232558139535 0.944148055683699 0.658886703889754 1 GO:0042910 xenobiotic transmembrane transporter activity 4/2571 32/18639 0.125 0.906213535589265 0.661472562577705 1 GO:0030215 semaphorin receptor binding 3/2571 24/18639 0.125 0.906213535589265 0.662311746407163 1 GO:0043998 histone H2A acetyltransferase activity 3/2571 24/18639 0.125 0.906213535589265 0.662311746407163 1 GO:0050699 WW domain binding 3/2571 24/18639 0.125 0.906213535589265 0.662311746407163 1 GO:0060229 lipase activator activity 3/2571 24/18639 0.125 0.906213535589265 0.662311746407163 1 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 5/2571 40/18639 0.125 0.906213535589265 0.663015169568094 1 GO:0004708 MAP kinase kinase activity 2/2571 16/18639 0.125 0.906213535589265 0.668917613020448 1 GO:0005149 interleukin-1 receptor binding 2/2571 16/18639 0.125 0.906213535589265 0.668917613020448 1 GO:0005521 lamin binding 2/2571 16/18639 0.125 0.906213535589265 0.668917613020448 1 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 2/2571 16/18639 0.125 0.906213535589265 0.668917613020448 1 GO:0070411 I-SMAD binding 2/2571 16/18639 0.125 0.906213535589265 0.668917613020448 1 GO:0001727 lipid kinase activity 5/2571 41/18639 0.121951219512195 0.884110766428551 0.684847351185315 1 GO:0016877 ligase activity, forming carbon-sulfur bonds 5/2571 41/18639 0.121951219512195 0.884110766428551 0.684847351185315 1 GO:0016504 peptidase activator activity 7/2571 57/18639 0.12280701754386 0.890315052508751 0.687469875763413 1 GO:0016407 acetyltransferase activity 12/2571 96/18639 0.125 0.906213535589265 0.687905907118026 1 GO:0003707 nuclear steroid receptor activity 3/2571 25/18639 0.12 0.869964994165694 0.689984352753434 1 GO:0015271 outward rectifier potassium channel activity 3/2571 25/18639 0.12 0.869964994165694 0.689984352753434 1 GO:0015662 P-type ion transporter activity 3/2571 25/18639 0.12 0.869964994165694 0.689984352753434 1 GO:0017025 TBP-class protein binding 3/2571 25/18639 0.12 0.869964994165694 0.689984352753434 1 GO:0140358 P-type transmembrane transporter activity 3/2571 25/18639 0.12 0.869964994165694 0.689984352753434 1 GO:0004549 tRNA-specific ribonuclease activity 2/2571 17/18639 0.117647058823529 0.852906857025191 0.701782270806644 1 GO:0015278 intracellularly gated calcium channel activity 2/2571 17/18639 0.117647058823529 0.852906857025191 0.701782270806644 1 GO:0016805 dipeptidase activity 2/2571 17/18639 0.117647058823529 0.852906857025191 0.701782270806644 1 GO:0030548 acetylcholine receptor regulator activity 2/2571 17/18639 0.117647058823529 0.852906857025191 0.701782270806644 1 GO:0031489 myosin V binding 2/2571 17/18639 0.117647058823529 0.852906857025191 0.701782270806644 1 GO:0046965 nuclear retinoid X receptor binding 2/2571 17/18639 0.117647058823529 0.852906857025191 0.701782270806644 1 GO:0070402 NADPH binding 2/2571 17/18639 0.117647058823529 0.852906857025191 0.701782270806644 1 GO:0070492 oligosaccharide binding 2/2571 17/18639 0.117647058823529 0.852906857025191 0.701782270806644 1 GO:1990226 histone methyltransferase binding 2/2571 17/18639 0.117647058823529 0.852906857025191 0.701782270806644 1 GO:0017116 single-stranded DNA helicase activity 7/2571 58/18639 0.120689655172414 0.874964792982739 0.705274363989147 1 GO:0016859 cis-trans isomerase activity 5/2571 42/18639 0.119047619047619 0.863060510085014 0.705701896665617 1 GO:0035064 methylated histone binding 9/2571 74/18639 0.121621621621622 0.881721277870636 0.70830054551724 1 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 4/2571 34/18639 0.117647058823529 0.852906857025191 0.708765278066854 1 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 4/2571 34/18639 0.117647058823529 0.852906857025191 0.708765278066854 1 GO:0016831 carboxy-lyase activity 4/2571 34/18639 0.117647058823529 0.852906857025191 0.708765278066854 1 GO:0090482 vitamin transmembrane transporter activity 4/2571 34/18639 0.117647058823529 0.852906857025191 0.708765278066854 1 GO:0005112 Notch binding 3/2571 26/18639 0.115384615384615 0.836504802082398 0.715913564603809 1 GO:0005160 transforming growth factor beta receptor binding 3/2571 26/18639 0.115384615384615 0.836504802082398 0.715913564603809 1 GO:0070412 R-SMAD binding 3/2571 26/18639 0.115384615384615 0.836504802082398 0.715913564603809 1 GO:0005201 extracellular matrix structural constituent 21/2571 168/18639 0.125 0.906213535589265 0.720187065052351 1 GO:1901681 sulfur compound binding 35/2571 275/18639 0.127272727272727 0.922690145327251 0.722882607067462 1 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 15/2571 122/18639 0.122950819672131 0.891357575989441 0.723447399905505 1 GO:0016798 hydrolase activity, acting on glycosyl bonds 16/2571 130/18639 0.123076923076923 0.892271788887892 0.726229473480978 1 GO:0005178 integrin binding 20/2571 161/18639 0.124223602484472 0.90058488008871 0.72722131801186 1 GO:0000175 3'-5'-RNA exonuclease activity 4/2571 35/18639 0.114285714285714 0.828538089681613 0.730527696171143 1 GO:0016229 steroid dehydrogenase activity 4/2571 35/18639 0.114285714285714 0.828538089681613 0.730527696171143 1 GO:0140566 histone reader activity 4/2571 35/18639 0.114285714285714 0.828538089681613 0.730527696171143 1 GO:0000900 mRNA regulatory element binding translation repressor activity 2/2571 18/18639 0.111111111111111 0.805523142746013 0.731883756866516 1 GO:0003746 translation elongation factor activity 2/2571 18/18639 0.111111111111111 0.805523142746013 0.731883756866516 1 GO:0005372 water transmembrane transporter activity 2/2571 18/18639 0.111111111111111 0.805523142746013 0.731883756866516 1 GO:0008525 phosphatidylcholine transporter activity 2/2571 18/18639 0.111111111111111 0.805523142746013 0.731883756866516 1 GO:0016854 racemase and epimerase activity 2/2571 18/18639 0.111111111111111 0.805523142746013 0.731883756866516 1 GO:0022851 GABA-gated chloride ion channel activity 2/2571 18/18639 0.111111111111111 0.805523142746013 0.731883756866516 1 GO:0034185 apolipoprotein binding 2/2571 18/18639 0.111111111111111 0.805523142746013 0.731883756866516 1 GO:0050811 GABA receptor binding 2/2571 18/18639 0.111111111111111 0.805523142746013 0.731883756866516 1 GO:0070064 proline-rich region binding 2/2571 18/18639 0.111111111111111 0.805523142746013 0.731883756866516 1 GO:0099602 neurotransmitter receptor regulator activity 2/2571 18/18639 0.111111111111111 0.805523142746013 0.731883756866516 1 GO:1901611 phosphatidylglycerol binding 2/2571 18/18639 0.111111111111111 0.805523142746013 0.731883756866516 1 GO:1990381 ubiquitin-specific protease binding 2/2571 18/18639 0.111111111111111 0.805523142746013 0.731883756866516 1 GO:0140034 methylation-dependent protein binding 9/2571 76/18639 0.118421052631579 0.858518086347725 0.738140945653426 1 GO:0140767 enzyme-substrate adaptor activity 17/2571 139/18639 0.122302158273381 0.88665497007295 0.739889245689391 1 GO:0015085 calcium ion transmembrane transporter activity 18/2571 147/18639 0.122448979591837 0.887719381801729 0.742332769287829 1 GO:0033218 amide binding 31/2571 247/18639 0.125506072874494 0.909882416300152 0.742407517190206 1 GO:0043014 alpha-tubulin binding 5/2571 44/18639 0.113636363636364 0.823830486899332 0.744455616203432 1 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 4/2571 36/18639 0.111111111111111 0.805523142746013 0.751046026351895 1 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 4/2571 36/18639 0.111111111111111 0.805523142746013 0.751046026351895 1 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 4/2571 36/18639 0.111111111111111 0.805523142746013 0.751046026351895 1 GO:0002039 p53 binding 8/2571 69/18639 0.115942028985507 0.840545888082796 0.752945734664574 1 GO:0015026 coreceptor activity 7/2571 61/18639 0.114754098360656 0.831933737590145 0.754552646717938 1 GO:0008146 sulfotransferase activity 6/2571 53/18639 0.113207547169811 0.820721692609146 0.757475947530819 1 GO:0003756 protein disulfide isomerase activity 2/2571 19/18639 0.105263157894737 0.763127187864644 0.759358754974898 1 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 2/2571 19/18639 0.105263157894737 0.763127187864644 0.759358754974898 1 GO:0004890 GABA-A receptor activity 2/2571 19/18639 0.105263157894737 0.763127187864644 0.759358754974898 1 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 2/2571 19/18639 0.105263157894737 0.763127187864644 0.759358754974898 1 GO:0016918 retinal binding 2/2571 19/18639 0.105263157894737 0.763127187864644 0.759358754974898 1 GO:0042800 histone H3K4 methyltransferase activity 2/2571 19/18639 0.105263157894737 0.763127187864644 0.759358754974898 1 GO:0046527 glucosyltransferase activity 2/2571 19/18639 0.105263157894737 0.763127187864644 0.759358754974898 1 GO:0070003 threonine-type peptidase activity 2/2571 19/18639 0.105263157894737 0.763127187864644 0.759358754974898 1 GO:0140036 ubiquitin-modified protein reader activity 2/2571 19/18639 0.105263157894737 0.763127187864644 0.759358754974898 1 GO:0051539 4 iron, 4 sulfur cluster binding 5/2571 45/18639 0.111111111111111 0.805523142746013 0.762361877207213 1 GO:0045499 chemorepellent activity 3/2571 28/18639 0.107142857142857 0.776754459076513 0.762671356640067 1 GO:0046625 sphingolipid binding 3/2571 28/18639 0.107142857142857 0.776754459076513 0.762671356640067 1 GO:0046966 nuclear thyroid hormone receptor binding 3/2571 28/18639 0.107142857142857 0.776754459076513 0.762671356640067 1 GO:0050698 proteoglycan sulfotransferase activity 3/2571 28/18639 0.107142857142857 0.776754459076513 0.762671356640067 1 GO:0042805 actinin binding 4/2571 37/18639 0.108108108108108 0.783752246996121 0.770340975423367 1 GO:0050661 NADP binding 6/2571 54/18639 0.111111111111111 0.805523142746013 0.773402220188837 1 GO:0004955 prostaglandin receptor activity 1/2571 10/18639 0.1 0.724970828471412 0.773418568839225 1 GO:0005031 tumor necrosis factor receptor activity 1/2571 10/18639 0.1 0.724970828471412 0.773418568839225 1 GO:0005522 profilin binding 1/2571 10/18639 0.1 0.724970828471412 0.773418568839225 1 GO:0008190 eukaryotic initiation factor 4E binding 1/2571 10/18639 0.1 0.724970828471412 0.773418568839225 1 GO:0008401 retinoic acid 4-hydroxylase activity 1/2571 10/18639 0.1 0.724970828471412 0.773418568839225 1 GO:0008519 ammonium channel activity 1/2571 10/18639 0.1 0.724970828471412 0.773418568839225 1 GO:0008641 ubiquitin-like modifier activating enzyme activity 1/2571 10/18639 0.1 0.724970828471412 0.773418568839225 1 GO:0015279 store-operated calcium channel activity 1/2571 10/18639 0.1 0.724970828471412 0.773418568839225 1 GO:0015643 toxic substance binding 1/2571 10/18639 0.1 0.724970828471412 0.773418568839225 1 GO:0016427 tRNA (cytidine) methyltransferase activity 1/2571 10/18639 0.1 0.724970828471412 0.773418568839225 1 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1/2571 10/18639 0.1 0.724970828471412 0.773418568839225 1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 1/2571 10/18639 0.1 0.724970828471412 0.773418568839225 1 GO:0016868 intramolecular phosphotransferase activity 1/2571 10/18639 0.1 0.724970828471412 0.773418568839225 1 GO:0016889 DNA endonuclease activity, producing 3'-phosphomonoesters 1/2571 10/18639 0.1 0.724970828471412 0.773418568839225 1 GO:0030957 Tat protein binding 1/2571 10/18639 0.1 0.724970828471412 0.773418568839225 1 GO:0031956 medium-chain fatty acid-CoA ligase activity 1/2571 10/18639 0.1 0.724970828471412 0.773418568839225 1 GO:0031996 thioesterase binding 1/2571 10/18639 0.1 0.724970828471412 0.773418568839225 1 GO:0035256 G protein-coupled glutamate receptor binding 1/2571 10/18639 0.1 0.724970828471412 0.773418568839225 1 GO:0042975 peroxisome proliferator activated receptor binding 1/2571 10/18639 0.1 0.724970828471412 0.773418568839225 1 GO:0043295 glutathione binding 1/2571 10/18639 0.1 0.724970828471412 0.773418568839225 1 GO:0043422 protein kinase B binding 1/2571 10/18639 0.1 0.724970828471412 0.773418568839225 1 GO:0045322 unmethylated CpG binding 1/2571 10/18639 0.1 0.724970828471412 0.773418568839225 1 GO:0050308 sugar-phosphatase activity 1/2571 10/18639 0.1 0.724970828471412 0.773418568839225 1 GO:0050815 phosphoserine residue binding 1/2571 10/18639 0.1 0.724970828471412 0.773418568839225 1 GO:0051880 G-quadruplex DNA binding 1/2571 10/18639 0.1 0.724970828471412 0.773418568839225 1 GO:0099122 RNA polymerase II C-terminal domain binding 1/2571 10/18639 0.1 0.724970828471412 0.773418568839225 1 GO:0140940 histone H2A methyltransferase activity 1/2571 10/18639 0.1 0.724970828471412 0.773418568839225 1 GO:1990259 histone H2AQ104 methyltransferase activity 1/2571 10/18639 0.1 0.724970828471412 0.773418568839225 1 GO:0008276 protein methyltransferase activity 11/2571 95/18639 0.115789473684211 0.839439906651108 0.777099511751382 1 GO:0008081 phosphoric diester hydrolase activity 10/2571 87/18639 0.114942528735632 0.833299802840703 0.777688227466597 1 GO:0019783 ubiquitin-like protein peptidase activity 15/2571 127/18639 0.118110236220472 0.856264758037101 0.77849606446709 1 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 5/2571 46/18639 0.108695652173913 0.788011770077622 0.779302917474055 1 GO:0003785 actin monomer binding 3/2571 29/18639 0.103448275862069 0.749969822556633 0.78359892113867 1 GO:0004181 metallocarboxypeptidase activity 3/2571 29/18639 0.103448275862069 0.749969822556633 0.78359892113867 1 GO:0051861 glycolipid binding 3/2571 29/18639 0.103448275862069 0.749969822556633 0.78359892113867 1 GO:0099604 ligand-gated calcium channel activity 3/2571 29/18639 0.103448275862069 0.749969822556633 0.78359892113867 1 GO:0000339 RNA cap binding 2/2571 20/18639 0.1 0.724970828471412 0.78435882269812 1 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 2/2571 20/18639 0.1 0.724970828471412 0.78435882269812 1 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 2/2571 20/18639 0.1 0.724970828471412 0.78435882269812 1 GO:0016004 phospholipase activator activity 2/2571 20/18639 0.1 0.724970828471412 0.78435882269812 1 GO:0042288 MHC class I protein binding 2/2571 20/18639 0.1 0.724970828471412 0.78435882269812 1 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 15/2571 128/18639 0.1171875 0.849575189614936 0.788536186294193 1 GO:0061749 forked DNA-dependent helicase activity 5/2571 47/18639 0.106382978723404 0.77124556220363 0.795296707262335 1 GO:0140938 histone H3 methyltransferase activity 5/2571 47/18639 0.106382978723404 0.77124556220363 0.795296707262335 1 GO:1990518 single-stranded 3'-5' DNA helicase activity 5/2571 47/18639 0.106382978723404 0.77124556220363 0.795296707262335 1 GO:0004536 DNA nuclease activity 7/2571 64/18639 0.109375 0.792936843640607 0.797623497422074 1 GO:0043021 ribonucleoprotein complex binding 21/2571 177/18639 0.11864406779661 0.860134881237268 0.802556356607677 1 GO:0001968 fibronectin binding 3/2571 30/18639 0.1 0.724970828471412 0.802974962894219 1 GO:0033612 receptor serine/threonine kinase binding 3/2571 30/18639 0.1 0.724970828471412 0.802974962894219 1 GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity 1/2571 11/18639 0.0909090909090909 0.659064389519465 0.804689214580508 1 GO:0004523 RNA-DNA hybrid ribonuclease activity 1/2571 11/18639 0.0909090909090909 0.659064389519465 0.804689214580508 1 GO:0004954 prostanoid receptor activity 1/2571 11/18639 0.0909090909090909 0.659064389519465 0.804689214580508 1 GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity 1/2571 11/18639 0.0909090909090909 0.659064389519465 0.804689214580508 1 GO:0005225 volume-sensitive anion channel activity 1/2571 11/18639 0.0909090909090909 0.659064389519465 0.804689214580508 1 GO:0008046 axon guidance receptor activity 1/2571 11/18639 0.0909090909090909 0.659064389519465 0.804689214580508 1 GO:0008199 ferric iron binding 1/2571 11/18639 0.0909090909090909 0.659064389519465 0.804689214580508 1 GO:0008432 JUN kinase binding 1/2571 11/18639 0.0909090909090909 0.659064389519465 0.804689214580508 1 GO:0010854 adenylate cyclase regulator activity 1/2571 11/18639 0.0909090909090909 0.659064389519465 0.804689214580508 1 GO:0016594 glycine binding 1/2571 11/18639 0.0909090909090909 0.659064389519465 0.804689214580508 1 GO:0019107 myristoyltransferase activity 1/2571 11/18639 0.0909090909090909 0.659064389519465 0.804689214580508 1 GO:0019203 carbohydrate phosphatase activity 1/2571 11/18639 0.0909090909090909 0.659064389519465 0.804689214580508 1 GO:0019206 nucleoside kinase activity 1/2571 11/18639 0.0909090909090909 0.659064389519465 0.804689214580508 1 GO:0031731 CCR6 chemokine receptor binding 1/2571 11/18639 0.0909090909090909 0.659064389519465 0.804689214580508 1 GO:0032794 GTPase activating protein binding 1/2571 11/18639 0.0909090909090909 0.659064389519465 0.804689214580508 1 GO:0034713 type I transforming growth factor beta receptor binding 1/2571 11/18639 0.0909090909090909 0.659064389519465 0.804689214580508 1 GO:0042608 T cell receptor binding 1/2571 11/18639 0.0909090909090909 0.659064389519465 0.804689214580508 1 GO:0043855 cyclic nucleotide-activated monoatomic ion channel activity 1/2571 11/18639 0.0909090909090909 0.659064389519465 0.804689214580508 1 GO:0047676 arachidonate-CoA ligase activity 1/2571 11/18639 0.0909090909090909 0.659064389519465 0.804689214580508 1 GO:0048101 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity 1/2571 11/18639 0.0909090909090909 0.659064389519465 0.804689214580508 1 GO:0180030 inositol phosphate kinase activity 1/2571 11/18639 0.0909090909090909 0.659064389519465 0.804689214580508 1 GO:1900750 oligopeptide binding 1/2571 11/18639 0.0909090909090909 0.659064389519465 0.804689214580508 1 GO:0016887 ATP hydrolysis activity 52/2571 417/18639 0.124700239808153 0.904040361643008 0.80524889251649 1 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 4/2571 39/18639 0.102564102564103 0.743559824073243 0.805380214877332 1 GO:0015125 bile acid transmembrane transporter activity 2/2571 21/18639 0.0952380952380952 0.690448408068011 0.807043691123849 1 GO:0035613 RNA stem-loop binding 2/2571 21/18639 0.0952380952380952 0.690448408068011 0.807043691123849 1 GO:0140098 catalytic activity, acting on RNA 48/2571 387/18639 0.124031007751938 0.899188624460666 0.808478683554208 1 GO:0009378 four-way junction helicase activity 5/2571 48/18639 0.104166666666667 0.755177946324387 0.810365546988233 1 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 5/2571 48/18639 0.104166666666667 0.755177946324387 0.810365546988233 1 GO:0036121 double-stranded DNA helicase activity 5/2571 48/18639 0.104166666666667 0.755177946324387 0.810365546988233 1 GO:0043138 3'-5' DNA helicase activity 5/2571 48/18639 0.104166666666667 0.755177946324387 0.810365546988233 1 GO:0001221 transcription coregulator binding 13/2571 115/18639 0.11304347826087 0.819532240880726 0.817920068468104 1 GO:0101005 deubiquitinase activity 13/2571 115/18639 0.11304347826087 0.819532240880726 0.817920068468104 1 GO:0003684 damaged DNA binding 8/2571 74/18639 0.108108108108108 0.783752246996121 0.818304213873686 1 GO:0004177 aminopeptidase activity 4/2571 40/18639 0.1 0.724970828471412 0.821198553245024 1 GO:0030331 nuclear estrogen receptor binding 4/2571 40/18639 0.1 0.724970828471412 0.821198553245024 1 GO:0001222 transcription corepressor binding 5/2571 49/18639 0.102040816326531 0.739766151501441 0.824535345078659 1 GO:0140597 protein carrier chaperone 22/2571 188/18639 0.117021276595745 0.848370118423993 0.826375506170551 1 GO:0005243 gap junction channel activity 2/2571 22/18639 0.0909090909090909 0.659064389519465 0.827576128874024 1 GO:0030021 extracellular matrix structural constituent conferring compression resistance 2/2571 22/18639 0.0909090909090909 0.659064389519465 0.827576128874024 1 GO:0034062 5'-3' RNA polymerase activity 2/2571 22/18639 0.0909090909090909 0.659064389519465 0.827576128874024 1 GO:0046972 histone H4K16 acetyltransferase activity 2/2571 22/18639 0.0909090909090909 0.659064389519465 0.827576128874024 1 GO:0050321 tau-protein kinase activity 2/2571 22/18639 0.0909090909090909 0.659064389519465 0.827576128874024 1 GO:0097747 RNA polymerase activity 2/2571 22/18639 0.0909090909090909 0.659064389519465 0.827576128874024 1 GO:0008408 3'-5' exonuclease activity 6/2571 58/18639 0.103448275862069 0.749969822556633 0.82928186360582 1 GO:0004032 aldose reductase (NADPH) activity 1/2571 12/18639 0.0833333333333333 0.60414235705951 0.831645625859953 1 GO:0004126 cytidine deaminase activity 1/2571 12/18639 0.0833333333333333 0.60414235705951 0.831645625859953 1 GO:0005527 macrolide binding 1/2571 12/18639 0.0833333333333333 0.60414235705951 0.831645625859953 1 GO:0008179 adenylate cyclase binding 1/2571 12/18639 0.0833333333333333 0.60414235705951 0.831645625859953 1 GO:0008603 cAMP-dependent protein kinase regulator activity 1/2571 12/18639 0.0833333333333333 0.60414235705951 0.831645625859953 1 GO:0010853 cyclase activator activity 1/2571 12/18639 0.0833333333333333 0.60414235705951 0.831645625859953 1 GO:0015166 polyol transmembrane transporter activity 1/2571 12/18639 0.0833333333333333 0.60414235705951 0.831645625859953 1 GO:0015269 calcium-activated potassium channel activity 1/2571 12/18639 0.0833333333333333 0.60414235705951 0.831645625859953 1 GO:0016273 arginine N-methyltransferase activity 1/2571 12/18639 0.0833333333333333 0.60414235705951 0.831645625859953 1 GO:0016274 protein-arginine N-methyltransferase activity 1/2571 12/18639 0.0833333333333333 0.60414235705951 0.831645625859953 1 GO:0034452 dynactin binding 1/2571 12/18639 0.0833333333333333 0.60414235705951 0.831645625859953 1 GO:0035251 UDP-glucosyltransferase activity 1/2571 12/18639 0.0833333333333333 0.60414235705951 0.831645625859953 1 GO:0036009 protein-glutamine N-methyltransferase activity 1/2571 12/18639 0.0833333333333333 0.60414235705951 0.831645625859953 1 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 1/2571 12/18639 0.0833333333333333 0.60414235705951 0.831645625859953 1 GO:0097371 MDM2/MDM4 family protein binding 1/2571 12/18639 0.0833333333333333 0.60414235705951 0.831645625859953 1 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 1/2571 12/18639 0.0833333333333333 0.60414235705951 0.831645625859953 1 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 1/2571 12/18639 0.0833333333333333 0.60414235705951 0.831645625859953 1 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 1/2571 12/18639 0.0833333333333333 0.60414235705951 0.831645625859953 1 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 1/2571 12/18639 0.0833333333333333 0.60414235705951 0.831645625859953 1 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 1/2571 12/18639 0.0833333333333333 0.60414235705951 0.831645625859953 1 GO:1990247 N6-methyladenosine-containing RNA reader activity 1/2571 12/18639 0.0833333333333333 0.60414235705951 0.831645625859953 1 GO:1990817 poly(A) RNA polymerase activity 1/2571 12/18639 0.0833333333333333 0.60414235705951 0.831645625859953 1 GO:0042054 histone methyltransferase activity 7/2571 67/18639 0.104477611940299 0.757432208850729 0.834693712770244 1 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 3/2571 32/18639 0.09375 0.679660151691949 0.83735957580319 1 GO:0051059 NF-kappaB binding 3/2571 32/18639 0.09375 0.679660151691949 0.83735957580319 1 GO:0070717 poly-purine tract binding 3/2571 32/18639 0.09375 0.679660151691949 0.83735957580319 1 GO:0140223 general transcription initiation factor activity 7/2571 68/18639 0.102941176470588 0.746293499897042 0.845781062529397 1 GO:0003887 DNA-directed DNA polymerase activity 2/2571 23/18639 0.0869565217391304 0.630409416062097 0.846118066586677 1 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 2/2571 23/18639 0.0869565217391304 0.630409416062097 0.846118066586677 1 GO:0005212 structural constituent of eye lens 2/2571 23/18639 0.0869565217391304 0.630409416062097 0.846118066586677 1 GO:0016917 GABA receptor activity 2/2571 23/18639 0.0869565217391304 0.630409416062097 0.846118066586677 1 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 2/2571 23/18639 0.0869565217391304 0.630409416062097 0.846118066586677 1 GO:0035198 miRNA binding 4/2571 42/18639 0.0952380952380952 0.690448408068011 0.849648416061371 1 GO:0016830 carbon-carbon lyase activity 5/2571 51/18639 0.0980392156862745 0.710755714187659 0.850295545258336 1 GO:0030544 Hsp70 protein binding 5/2571 51/18639 0.0980392156862745 0.710755714187659 0.850295545258336 1 GO:0003724 RNA helicase activity 8/2571 77/18639 0.103896103896104 0.753216445165103 0.850606560646655 1 GO:0019239 deaminase activity 3/2571 33/18639 0.0909090909090909 0.659064389519465 0.852520815149261 1 GO:0001098 basal transcription machinery binding 6/2571 60/18639 0.1 0.724970828471412 0.852778380770521 1 GO:0001099 basal RNA polymerase II transcription machinery binding 6/2571 60/18639 0.1 0.724970828471412 0.852778380770521 1 GO:0008237 metallopeptidase activity 21/2571 184/18639 0.114130434782609 0.827412358581503 0.853671501786721 1 GO:0002161 aminoacyl-tRNA editing activity 1/2571 13/18639 0.0769230769230769 0.557669868054932 0.854882813593569 1 GO:0005035 death receptor activity 1/2571 13/18639 0.0769230769230769 0.557669868054932 0.854882813593569 1 GO:0008253 5'-nucleotidase activity 1/2571 13/18639 0.0769230769230769 0.557669868054932 0.854882813593569 1 GO:0008417 fucosyltransferase activity 1/2571 13/18639 0.0769230769230769 0.557669868054932 0.854882813593569 1 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 1/2571 13/18639 0.0769230769230769 0.557669868054932 0.854882813593569 1 GO:0030955 potassium ion binding 1/2571 13/18639 0.0769230769230769 0.557669868054932 0.854882813593569 1 GO:0031432 titin binding 1/2571 13/18639 0.0769230769230769 0.557669868054932 0.854882813593569 1 GO:0071714 icosanoid transmembrane transporter activity 1/2571 13/18639 0.0769230769230769 0.557669868054932 0.854882813593569 1 GO:0071837 HMG box domain binding 1/2571 13/18639 0.0769230769230769 0.557669868054932 0.854882813593569 1 GO:0140410 monoatomic cation:bicarbonate symporter activity 1/2571 13/18639 0.0769230769230769 0.557669868054932 0.854882813593569 1 GO:0048156 tau protein binding 4/2571 43/18639 0.0930232558139535 0.674391468345499 0.86237427730954 1 GO:0005540 hyaluronic acid binding 2/2571 24/18639 0.0833333333333333 0.60414235705951 0.862827732057542 1 GO:0030552 cAMP binding 2/2571 24/18639 0.0833333333333333 0.60414235705951 0.862827732057542 1 GO:0050431 transforming growth factor beta binding 2/2571 24/18639 0.0833333333333333 0.60414235705951 0.862827732057542 1 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 2/2571 24/18639 0.0833333333333333 0.60414235705951 0.862827732057542 1 GO:0070840 dynein complex binding 2/2571 24/18639 0.0833333333333333 0.60414235705951 0.862827732057542 1 GO:0015020 glucuronosyltransferase activity 3/2571 34/18639 0.0882352941176471 0.639680142768893 0.866432641318526 1 GO:0005506 iron ion binding 17/2571 154/18639 0.11038961038961 0.800292472987922 0.868958690643376 1 GO:0008186 ATP-dependent activity, acting on RNA 8/2571 79/18639 0.10126582278481 0.73414767440143 0.869467728443513 1 GO:0140296 general transcription initiation factor binding 5/2571 53/18639 0.0943396226415094 0.683934743840955 0.872832807866719 1 GO:0030020 extracellular matrix structural constituent conferring tensile strength 4/2571 44/18639 0.0909090909090909 0.659064389519465 0.874166143420151 1 GO:0008191 metalloendopeptidase inhibitor activity 1/2571 14/18639 0.0714285714285714 0.517836306051008 0.874913753476042 1 GO:0008494 translation activator activity 1/2571 14/18639 0.0714285714285714 0.517836306051008 0.874913753476042 1 GO:0016530 metallochaperone activity 1/2571 14/18639 0.0714285714285714 0.517836306051008 0.874913753476042 1 GO:0019992 diacylglycerol binding 1/2571 14/18639 0.0714285714285714 0.517836306051008 0.874913753476042 1 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 1/2571 14/18639 0.0714285714285714 0.517836306051008 0.874913753476042 1 GO:0034236 protein kinase A catalytic subunit binding 1/2571 14/18639 0.0714285714285714 0.517836306051008 0.874913753476042 1 GO:0042043 neurexin family protein binding 1/2571 14/18639 0.0714285714285714 0.517836306051008 0.874913753476042 1 GO:0043176 amine binding 1/2571 14/18639 0.0714285714285714 0.517836306051008 0.874913753476042 1 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 1/2571 14/18639 0.0714285714285714 0.517836306051008 0.874913753476042 1 GO:1901474 azole transmembrane transporter activity 1/2571 14/18639 0.0714285714285714 0.517836306051008 0.874913753476042 1 GO:0005537 D-mannose binding 2/2571 25/18639 0.08 0.57997666277713 0.877857591127464 1 GO:0008483 transaminase activity 2/2571 25/18639 0.08 0.57997666277713 0.877857591127464 1 GO:0140101 catalytic activity, acting on a tRNA 15/2571 139/18639 0.107913669064748 0.782342620652603 0.878239611219805 1 GO:0043015 gamma-tubulin binding 3/2571 35/18639 0.0857142857142857 0.62140356726121 0.879173729926094 1 GO:0005262 calcium channel activity 14/2571 131/18639 0.106870229007634 0.774777984625936 0.880105452589397 1 GO:0003727 single-stranded RNA binding 9/2571 89/18639 0.101123595505618 0.733116568117158 0.881238871113926 1 GO:0003925 G protein activity 5/2571 54/18639 0.0925925925925926 0.671269285621678 0.882978786201196 1 GO:0140463 chromatin-protein adaptor activity 5/2571 54/18639 0.0925925925925926 0.671269285621678 0.882978786201196 1 GO:0008143 poly(A) binding 2/2571 26/18639 0.0769230769230769 0.557669868054932 0.891352926671102 1 GO:0019865 immunoglobulin binding 2/2571 26/18639 0.0769230769230769 0.557669868054932 0.891352926671102 1 GO:0030507 spectrin binding 2/2571 26/18639 0.0769230769230769 0.557669868054932 0.891352926671102 1 GO:0052742 phosphatidylinositol kinase activity 2/2571 26/18639 0.0769230769230769 0.557669868054932 0.891352926671102 1 GO:0070006 metalloaminopeptidase activity 2/2571 26/18639 0.0769230769230769 0.557669868054932 0.891352926671102 1 GO:0005523 tropomyosin binding 1/2571 15/18639 0.0666666666666667 0.483313885647608 0.892180692526409 1 GO:0008020 G protein-coupled photoreceptor activity 1/2571 15/18639 0.0666666666666667 0.483313885647608 0.892180692526409 1 GO:0030553 cGMP binding 1/2571 15/18639 0.0666666666666667 0.483313885647608 0.892180692526409 1 GO:0031386 protein tag activity 1/2571 15/18639 0.0666666666666667 0.483313885647608 0.892180692526409 1 GO:0045504 dynein heavy chain binding 1/2571 15/18639 0.0666666666666667 0.483313885647608 0.892180692526409 1 GO:0061578 K63-linked deubiquitinase activity 1/2571 15/18639 0.0666666666666667 0.483313885647608 0.892180692526409 1 GO:0120283 protein serine/threonine kinase binding 1/2571 15/18639 0.0666666666666667 0.483313885647608 0.892180692526409 1 GO:0141047 molecular tag activity 1/2571 15/18639 0.0666666666666667 0.483313885647608 0.892180692526409 1 GO:0004843 cysteine-type deubiquitinase activity 11/2571 108/18639 0.101851851851852 0.738396214183845 0.894824932966713 1 GO:0030291 protein serine/threonine kinase inhibitor activity 4/2571 46/18639 0.0869565217391304 0.630409416062097 0.895147301398281 1 GO:0003678 DNA helicase activity 7/2571 74/18639 0.0945945945945946 0.685783216121606 0.90027868012464 1 GO:0030280 structural constituent of skin epidermis 3/2571 37/18639 0.0810810810810811 0.587814185247091 0.901452355409611 1 GO:0043394 proteoglycan binding 3/2571 37/18639 0.0810810810810811 0.587814185247091 0.901452355409611 1 GO:0046982 protein heterodimerization activity 43/2571 369/18639 0.116531165311653 0.844816954587282 0.902079179788781 1 GO:0005044 scavenger receptor activity 2/2571 27/18639 0.0740740740740741 0.537015428497342 0.903450918934607 1 GO:0005104 fibroblast growth factor receptor binding 2/2571 27/18639 0.0740740740740741 0.537015428497342 0.903450918934607 1 GO:0008266 poly(U) RNA binding 2/2571 27/18639 0.0740740740740741 0.537015428497342 0.903450918934607 1 GO:0003689 DNA clamp loader activity 17/2571 160/18639 0.10625 0.770281505250875 0.903865174003001 1 GO:0015079 potassium ion transmembrane transporter activity 17/2571 160/18639 0.10625 0.770281505250875 0.903865174003001 1 GO:0005504 fatty acid binding 4/2571 47/18639 0.0851063829787234 0.616996449762904 0.904435728759765 1 GO:0099095 ligand-gated monoatomic anion channel activity 4/2571 47/18639 0.0851063829787234 0.616996449762904 0.904435728759765 1 GO:0003688 DNA replication origin binding 1/2571 16/18639 0.0625 0.453106767794632 0.907064897826807 1 GO:0017070 U6 snRNA binding 1/2571 16/18639 0.0625 0.453106767794632 0.907064897826807 1 GO:0019841 retinol binding 1/2571 16/18639 0.0625 0.453106767794632 0.907064897826807 1 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity 1/2571 16/18639 0.0625 0.453106767794632 0.907064897826807 1 GO:0034450 ubiquitin-ubiquitin ligase activity 1/2571 16/18639 0.0625 0.453106767794632 0.907064897826807 1 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 1/2571 16/18639 0.0625 0.453106767794632 0.907064897826807 1 GO:0140328 floppase activity 1/2571 16/18639 0.0625 0.453106767794632 0.907064897826807 1 GO:0004222 metalloendopeptidase activity 11/2571 110/18639 0.1 0.724970828471412 0.907311868048137 1 GO:0004527 exonuclease activity 8/2571 84/18639 0.0952380952380952 0.690448408068011 0.908209374625914 1 GO:0005109 frizzled binding 3/2571 38/18639 0.0789473684210526 0.572345390898483 0.911139055150189 1 GO:0038187 pattern recognition receptor activity 4/2571 48/18639 0.0833333333333333 0.60414235705951 0.912987563466268 1 GO:0019789 SUMO transferase activity 2/2571 28/18639 0.0714285714285714 0.517836306051008 0.914280116034187 1 GO:0046875 ephrin receptor binding 2/2571 28/18639 0.0714285714285714 0.517836306051008 0.914280116034187 1 GO:0042562 hormone binding 9/2571 94/18639 0.0957446808510638 0.694121005983267 0.915564715749865 1 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 1/2571 17/18639 0.0588235294117647 0.426453428512595 0.919895062015567 1 GO:0009881 photoreceptor activity 1/2571 17/18639 0.0588235294117647 0.426453428512595 0.919895062015567 1 GO:0016018 cyclosporin A binding 1/2571 17/18639 0.0588235294117647 0.426453428512595 0.919895062015567 1 GO:0036041 long-chain fatty acid binding 1/2571 17/18639 0.0588235294117647 0.426453428512595 0.919895062015567 1 GO:0045125 bioactive lipid receptor activity 1/2571 17/18639 0.0588235294117647 0.426453428512595 0.919895062015567 1 GO:0045236 CXCR chemokine receptor binding 1/2571 17/18639 0.0588235294117647 0.426453428512595 0.919895062015567 1 GO:0070888 E-box binding 5/2571 59/18639 0.0847457627118644 0.61438205802662 0.923898252670869 1 GO:0106222 lncRNA binding 2/2571 29/18639 0.0689655172413793 0.499979881704422 0.923960204544966 1 GO:0005216 monoatomic ion channel activity 52/2571 448/18639 0.116071428571429 0.841483997332889 0.925959863681661 1 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 5/2571 60/18639 0.0833333333333333 0.60414235705951 0.9303636955709 1 GO:0000400 four-way junction DNA binding 1/2571 18/18639 0.0555555555555556 0.402761571373007 0.930954550553746 1 GO:0008409 5'-3' exonuclease activity 1/2571 18/18639 0.0555555555555556 0.402761571373007 0.930954550553746 1 GO:0015280 ligand-gated sodium channel activity 1/2571 18/18639 0.0555555555555556 0.402761571373007 0.930954550553746 1 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 1/2571 18/18639 0.0555555555555556 0.402761571373007 0.930954550553746 1 GO:0031690 adrenergic receptor binding 1/2571 18/18639 0.0555555555555556 0.402761571373007 0.930954550553746 1 GO:0033293 monocarboxylic acid binding 7/2571 79/18639 0.0886075949367089 0.642379215101251 0.9322652278188 1 GO:0001965 G-protein alpha-subunit binding 2/2571 30/18639 0.0666666666666667 0.483313885647608 0.932602007520019 1 GO:0008187 poly-pyrimidine tract binding 2/2571 30/18639 0.0666666666666667 0.483313885647608 0.932602007520019 1 GO:0070566 adenylyltransferase activity 2/2571 30/18639 0.0666666666666667 0.483313885647608 0.932602007520019 1 GO:0098918 structural constituent of synapse 2/2571 30/18639 0.0666666666666667 0.483313885647608 0.932602007520019 1 GO:0005048 signal sequence binding 4/2571 51/18639 0.0784313725490196 0.568604571350127 0.934687671598507 1 GO:0005272 sodium channel activity 4/2571 51/18639 0.0784313725490196 0.568604571350127 0.934687671598507 1 GO:0001530 lipopolysaccharide binding 3/2571 41/18639 0.0731707317073171 0.530466459857131 0.935224098672035 1 GO:0004812 aminoacyl-tRNA ligase activity 3/2571 41/18639 0.0731707317073171 0.530466459857131 0.935224098672035 1 GO:0016875 ligase activity, forming carbon-oxygen bonds 3/2571 41/18639 0.0731707317073171 0.530466459857131 0.935224098672035 1 GO:0000510 H3-H4 histone complex chaperone activity 15/2571 151/18639 0.0993377483443709 0.720169697157032 0.938515092534612 1 GO:0140584 chromatin extrusion motor activity 15/2571 151/18639 0.0993377483443709 0.720169697157032 0.938515092534612 1 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 15/2571 151/18639 0.0993377483443709 0.720169697157032 0.938515092534612 1 GO:0140849 ATP-dependent H2AZ histone chaperone activity 15/2571 151/18639 0.0993377483443709 0.720169697157032 0.938515092534612 1 GO:0140299 molecular sensor activity 6/2571 71/18639 0.0845070422535211 0.612651404342038 0.939057671228282 1 GO:0005184 neuropeptide hormone activity 2/2571 31/18639 0.0645161290322581 0.467723115142846 0.940307651603241 1 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 1/2571 19/18639 0.0526315789473684 0.381563593932322 0.940487650308127 1 GO:0005229 intracellularly calcium-gated chloride channel activity 1/2571 19/18639 0.0526315789473684 0.381563593932322 0.940487650308127 1 GO:0008301 DNA binding, bending 1/2571 19/18639 0.0526315789473684 0.381563593932322 0.940487650308127 1 GO:0043395 heparan sulfate proteoglycan binding 1/2571 19/18639 0.0526315789473684 0.381563593932322 0.940487650308127 1 GO:0046624 sphingolipid transporter activity 1/2571 19/18639 0.0526315789473684 0.381563593932322 0.940487650308127 1 GO:0141147 intracellularly calcium-gated channel activity 1/2571 19/18639 0.0526315789473684 0.381563593932322 0.940487650308127 1 GO:0043175 RNA polymerase core enzyme binding 3/2571 42/18639 0.0714285714285714 0.517836306051008 0.94180684348824 1 GO:0015616 DNA translocase activity 15/2571 152/18639 0.0986842105263158 0.715431738623104 0.942123172888168 1 GO:0140674 ATP-dependent histone chaperone activity 15/2571 152/18639 0.0986842105263158 0.715431738623104 0.942123172888168 1 GO:0019955 cytokine binding 14/2571 144/18639 0.0972222222222222 0.704832749902762 0.944379502440944 1 GO:0061775 cohesin loader activity 15/2571 153/18639 0.0980392156862745 0.710755714187659 0.945547831607652 1 GO:0016251 RNA polymerase II general transcription initiation factor activity 4/2571 53/18639 0.0754716981132075 0.547147795072764 0.946293327276381 1 GO:0017046 peptide hormone binding 4/2571 53/18639 0.0754716981132075 0.547147795072764 0.946293327276381 1 GO:0004842 ubiquitin-protein transferase activity 51/2571 449/18639 0.11358574610245 0.823463524544365 0.946391338421158 1 GO:0016779 nucleotidyltransferase activity 13/2571 136/18639 0.0955882352941176 0.692986821332967 0.946864568290489 1 GO:0030515 snoRNA binding 2/2571 32/18639 0.0625 0.453106767794632 0.947170856656578 1 GO:0031369 translation initiation factor binding 2/2571 32/18639 0.0625 0.453106767794632 0.947170856656578 1 GO:0160041 neuropeptide activity 2/2571 32/18639 0.0625 0.453106767794632 0.947170856656578 1 GO:0061630 ubiquitin protein ligase activity 39/2571 353/18639 0.110481586402266 0.800959272248869 0.947328968883195 1 GO:0005245 voltage-gated calcium channel activity 3/2571 43/18639 0.0697674418604651 0.505793601259125 0.947764285951643 1 GO:0005326 neurotransmitter transmembrane transporter activity 1/2571 20/18639 0.05 0.362485414235706 0.948704957024443 1 GO:0010851 cyclase regulator activity 1/2571 20/18639 0.05 0.362485414235706 0.948704957024443 1 GO:0016408 C-acyltransferase activity 1/2571 20/18639 0.05 0.362485414235706 0.948704957024443 1 GO:0016505 peptidase activator activity involved in apoptotic process 1/2571 20/18639 0.05 0.362485414235706 0.948704957024443 1 GO:0061608 nuclear import signal receptor activity 1/2571 20/18639 0.05 0.362485414235706 0.948704957024443 1 GO:0140664 ATP-dependent DNA damage sensor activity 1/2571 20/18639 0.05 0.362485414235706 0.948704957024443 1 GO:0031490 chromatin DNA binding 12/2571 128/18639 0.09375 0.679660151691949 0.949599410335426 1 GO:0008201 heparin binding 17/2571 172/18639 0.0988372093023256 0.716540935117093 0.951058980619922 1 GO:0004386 helicase activity 15/2571 155/18639 0.0967741935483871 0.70158467271427 0.951875344433987 1 GO:0017171 serine hydrolase activity 20/2571 198/18639 0.101010101010101 0.732293766132739 0.952123093781359 1 GO:0140713 histone chaperone activity 16/2571 164/18639 0.0975609756097561 0.707288613142841 0.952847317952522 1 GO:0019956 chemokine binding 2/2571 33/18639 0.0606060606060606 0.439376259679644 0.953277310947373 1 GO:0140311 protein sequestering activity 2/2571 33/18639 0.0606060606060606 0.439376259679644 0.953277310947373 1 GO:0005244 voltage-gated monoatomic ion channel activity 17/2571 173/18639 0.0982658959537572 0.712399080000809 0.953882902755459 1 GO:0140375 immune receptor activity 15/2571 156/18639 0.0961538461538462 0.697087335068665 0.954792142556226 1 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 1/2571 21/18639 0.0476190476190476 0.345224204034006 0.955788020319473 1 GO:0051428 peptide hormone receptor binding 1/2571 21/18639 0.0476190476190476 0.345224204034006 0.955788020319473 1 GO:0019825 oxygen binding 2/2571 34/18639 0.0588235294117647 0.426453428512595 0.958705102799176 1 GO:0030332 cyclin binding 2/2571 34/18639 0.0588235294117647 0.426453428512595 0.958705102799176 1 GO:0022832 voltage-gated channel activity 17/2571 175/18639 0.0971428571428571 0.704257376229372 0.959108673360247 1 GO:0140658 ATP-dependent chromatin remodeler activity 15/2571 158/18639 0.0949367088607595 0.68826344475134 0.960165697218794 1 GO:0031683 G-protein beta/gamma-subunit complex binding 1/2571 22/18639 0.0454545454545455 0.329532194759733 0.961893348483541 1 GO:0033038 bitter taste receptor activity 1/2571 22/18639 0.0454545454545455 0.329532194759733 0.961893348483541 1 GO:0033691 sialic acid binding 1/2571 22/18639 0.0454545454545455 0.329532194759733 0.961893348483541 1 GO:0070034 telomerase RNA binding 1/2571 22/18639 0.0454545454545455 0.329532194759733 0.961893348483541 1 GO:0140517 protein-RNA adaptor activity 1/2571 22/18639 0.0454545454545455 0.329532194759733 0.961893348483541 1 GO:0034061 DNA polymerase activity 2/2571 35/18639 0.0571428571428571 0.414269044840807 0.963525186003605 1 GO:0004497 monooxygenase activity 9/2571 106/18639 0.0849056603773585 0.615541269456859 0.965332683243788 1 GO:0030246 carbohydrate binding 29/2571 280/18639 0.103571428571429 0.750862643773962 0.965484058580929 1 GO:0005158 insulin receptor binding 1/2571 23/18639 0.0434782608695652 0.315204708031049 0.967155861297035 1 GO:0016493 C-C chemokine receptor activity 1/2571 23/18639 0.0434782608695652 0.315204708031049 0.967155861297035 1 GO:0031681 G-protein beta-subunit binding 1/2571 23/18639 0.0434782608695652 0.315204708031049 0.967155861297035 1 GO:0099186 structural constituent of postsynapse 1/2571 23/18639 0.0434782608695652 0.315204708031049 0.967155861297035 1 GO:0061980 regulatory RNA binding 4/2571 58/18639 0.0689655172413793 0.499979881704422 0.967522585629228 1 GO:0000993 RNA polymerase II complex binding 2/2571 36/18639 0.0555555555555556 0.402761571373007 0.967801861475682 1 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 2/2571 36/18639 0.0555555555555556 0.402761571373007 0.967801861475682 1 GO:0019787 ubiquitin-like protein transferase activity 53/2571 479/18639 0.110647181628392 0.802159789331625 0.968690670864932 1 GO:0005249 voltage-gated potassium channel activity 8/2571 98/18639 0.0816326530612245 0.591812921201152 0.968976234622748 1 GO:0016755 aminoacyltransferase activity 55/2571 496/18639 0.110887096774194 0.803899104151767 0.969731749460041 1 GO:0046332 SMAD binding 6/2571 79/18639 0.0759493670886076 0.550610755801072 0.969817961403406 1 GO:0042277 peptide binding 25/2571 249/18639 0.100401606425703 0.727882357903024 0.970034204194391 1 GO:0023023 MHC protein complex binding 2/2571 37/18639 0.0540540540540541 0.391876123498061 0.971593261822315 1 GO:0030551 cyclic nucleotide binding 2/2571 37/18639 0.0540540540540541 0.391876123498061 0.971593261822315 1 GO:0019957 C-C chemokine binding 1/2571 24/18639 0.0416666666666667 0.302071178529755 0.971691866916144 1 GO:0035035 histone acetyltransferase binding 1/2571 24/18639 0.0416666666666667 0.302071178529755 0.971691866916144 1 GO:0048027 mRNA 5'-UTR binding 1/2571 24/18639 0.0416666666666667 0.302071178529755 0.971691866916144 1 GO:0140612 DNA damage sensor activity 1/2571 24/18639 0.0416666666666667 0.302071178529755 0.971691866916144 1 GO:0005125 cytokine activity 23/2571 234/18639 0.0982905982905983 0.712578164736858 0.973298223940723 1 GO:0005501 retinoid binding 2/2571 38/18639 0.0526315789473684 0.381563593932322 0.974951828859655 1 GO:0019840 isoprenoid binding 2/2571 38/18639 0.0526315789473684 0.381563593932322 0.974951828859655 1 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 7/2571 91/18639 0.0769230769230769 0.557669868054932 0.97515772738477 1 GO:0001848 complement binding 1/2571 25/18639 0.04 0.289988331388565 0.975601628407339 1 GO:0008139 nuclear localization sequence binding 1/2571 25/18639 0.04 0.289988331388565 0.975601628407339 1 GO:0061659 ubiquitin-like protein ligase activity 39/2571 372/18639 0.104838709677419 0.760050062107125 0.977377938048434 1 GO:0003697 single-stranded DNA binding 10/2571 121/18639 0.0826446280991736 0.599149445017696 0.977724940914256 1 GO:0000217 DNA secondary structure binding 2/2571 39/18639 0.0512820512820513 0.371779912036621 0.977924776806685 1 GO:0008236 serine-type peptidase activity 18/2571 194/18639 0.0927835051546392 0.672653346004403 0.978383276223468 1 GO:0001637 G protein-coupled chemoattractant receptor activity 1/2571 26/18639 0.0384615384615385 0.278834934027466 0.978971576476788 1 GO:0004435 phosphatidylinositol phospholipase C activity 1/2571 26/18639 0.0384615384615385 0.278834934027466 0.978971576476788 1 GO:0004950 chemokine receptor activity 1/2571 26/18639 0.0384615384615385 0.278834934027466 0.978971576476788 1 GO:0005227 calcium-activated cation channel activity 1/2571 26/18639 0.0384615384615385 0.278834934027466 0.978971576476788 1 GO:0042393 histone binding 24/2571 247/18639 0.097165991902834 0.704425096490441 0.979222097884994 1 GO:0005261 monoatomic cation channel activity 35/2571 341/18639 0.102639296187683 0.744104955909074 0.979823054275043 1 GO:0005179 hormone activity 11/2571 132/18639 0.0833333333333333 0.60414235705951 0.980380272658 1 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 2/2571 40/18639 0.05 0.362485414235706 0.980554536021477 1 GO:0005507 copper ion binding 4/2571 63/18639 0.0634920634920635 0.460298938712007 0.980703735621424 1 GO:0140104 molecular carrier activity 24/2571 249/18639 0.0963855421686747 0.698767063586903 0.981488853401433 1 GO:0005126 cytokine receptor binding 27/2571 275/18639 0.0981818181818182 0.711789540681023 0.981646664776616 1 GO:0008395 steroid hydroxylase activity 1/2571 27/18639 0.037037037037037 0.268507714248671 0.981876217151487 1 GO:0023026 MHC class II protein complex binding 1/2571 27/18639 0.037037037037037 0.268507714248671 0.981876217151487 1 GO:0005267 potassium channel activity 10/2571 124/18639 0.0806451612903226 0.584653893928558 0.982433751792696 1 GO:0022843 voltage-gated monoatomic cation channel activity 12/2571 143/18639 0.0839160839160839 0.608367128787199 0.982735632302666 1 GO:0042287 MHC protein binding 2/2571 41/18639 0.0487804878048781 0.35364430657142 0.982879173834269 1 GO:0140097 catalytic activity, acting on DNA 34/2571 336/18639 0.101190476190476 0.733601433572262 0.98301941729499 1 GO:0003725 double-stranded RNA binding 5/2571 75/18639 0.0666666666666667 0.483313885647608 0.983219613162074 1 GO:0005242 inward rectifier potassium channel activity 1/2571 28/18639 0.0357142857142857 0.258918153025504 0.984379776452128 1 GO:0008527 taste receptor activity 1/2571 28/18639 0.0357142857142857 0.258918153025504 0.984379776452128 1 GO:0016866 intramolecular transferase activity 1/2571 28/18639 0.0357142857142857 0.258918153025504 0.984379776452128 1 GO:0004175 endopeptidase activity 42/2571 405/18639 0.103703703703704 0.751821599896279 0.984546701591634 1 GO:0017069 snRNA binding 3/2571 54/18639 0.0555555555555556 0.402761571373007 0.984811123402713 1 GO:0048487 beta-tubulin binding 2/2571 42/18639 0.0476190476190476 0.345224204034006 0.984932790351571 1 GO:0004629 phospholipase C activity 1/2571 29/18639 0.0344827586206897 0.249989940852211 0.986537618305955 1 GO:0003735 structural constituent of ribosome 15/2571 175/18639 0.0857142857142857 0.62140356726121 0.987401370140606 1 GO:0030547 signaling receptor inhibitor activity 2/2571 44/18639 0.0454545454545455 0.329532194759733 0.988345715376425 1 GO:0022839 monoatomic ion-gated channel activity 1/2571 30/18639 0.0333333333333333 0.241656942823804 0.988397466953746 1 GO:0035925 mRNA 3'-UTR AU-rich region binding 1/2571 30/18639 0.0333333333333333 0.241656942823804 0.988397466953746 1 GO:0048019 receptor antagonist activity 1/2571 30/18639 0.0333333333333333 0.241656942823804 0.988397466953746 1 GO:0008009 chemokine activity 2/2571 45/18639 0.0444444444444444 0.322209257098405 0.989756582996307 1 GO:0042605 peptide antigen binding 2/2571 45/18639 0.0444444444444444 0.322209257098405 0.989756582996307 1 GO:0008327 methyl-CpG binding 1/2571 31/18639 0.032258064516129 0.233861557571423 0.990000460798763 1 GO:0005539 glycosaminoglycan binding 22/2571 242/18639 0.0909090909090909 0.659064389519465 0.990262547068378 1 GO:0140142 nucleocytoplasmic carrier activity 1/2571 32/18639 0.03125 0.226553383897316 0.991382060932382 1 GO:0070063 RNA polymerase binding 3/2571 59/18639 0.0508474576271186 0.368629234815972 0.991538626335091 1 GO:0042923 neuropeptide binding 1/2571 33/18639 0.0303030303030303 0.219688129839822 0.992572834369414 1 GO:0008094 ATP-dependent activity, acting on DNA 18/2571 210/18639 0.0857142857142857 0.62140356726121 0.992582636594293 1 GO:0042379 chemokine receptor binding 4/2571 72/18639 0.0555555555555556 0.402761571373007 0.992718181836657 1 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 4/2571 73/18639 0.0547945205479452 0.397244289573376 0.993482476565171 1 GO:0051427 hormone receptor binding 1/2571 34/18639 0.0294117647058824 0.213226714256298 0.993599129265481 1 GO:0042826 histone deacetylase binding 9/2571 127/18639 0.0708661417322835 0.51375885482226 0.994027065948472 1 GO:0004252 serine-type endopeptidase activity 14/2571 176/18639 0.0795454545454545 0.576681340829532 0.994161123662615 1 GO:0022824 transmitter-gated monoatomic ion channel activity 3/2571 63/18639 0.0476190476190476 0.345224204034006 0.994746479491113 1 GO:0022835 transmitter-gated channel activity 3/2571 63/18639 0.0476190476190476 0.345224204034006 0.994746479491113 1 GO:0055106 ubiquitin-protein transferase regulator activity 1/2571 36/18639 0.0277777777777778 0.201380785686503 0.9952459940237 1 GO:0022836 gated channel activity 29/2571 318/18639 0.0911949685534591 0.661136919046256 0.995905107328825 1 GO:0008227 G protein-coupled amine receptor activity 1/2571 41/18639 0.024390243902439 0.17682215328571 0.997740325580873 1 GO:0031492 nucleosomal DNA binding 1/2571 42/18639 0.0238095238095238 0.172612102017003 0.998052704488905 1 GO:0001664 G protein-coupled receptor binding 25/2571 297/18639 0.0841750841750842 0.610244805110616 0.998470843396376 1 GO:0022834 ligand-gated channel activity 13/2571 188/18639 0.0691489361702128 0.501309615432359 0.999028358901998 1 GO:0099094 ligand-gated monoatomic cation channel activity 8/2571 136/18639 0.0588235294117647 0.426453428512595 0.999051405679491 1 GO:0008188 neuropeptide receptor activity 1/2571 48/18639 0.0208333333333333 0.151035589264877 0.999202613023446 1 GO:0048020 CCR chemokine receptor binding 1/2571 50/18639 0.02 0.144994165694282 0.999407913838479 1 GO:0015276 ligand-gated monoatomic ion channel activity 12/2571 186/18639 0.0645161290322581 0.467723115142846 0.999534992972829 1 GO:0030594 neurotransmitter receptor activity 4/2571 97/18639 0.0412371134020619 0.298957042668623 0.99959662624372 1 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 1/2571 53/18639 0.0188679245283019 0.136786948768191 0.999621182140682 1 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 1/2571 56/18639 0.0178571428571429 0.129459076512752 0.999757650447936 1 GO:0031491 nucleosome binding 2/2571 74/18639 0.027027027027027 0.19593806174903 0.999786099951858 1 GO:0036002 pre-mRNA binding 1/2571 59/18639 0.0169491525423729 0.122876411605324 0.999844968401042 1 GO:0008528 G protein-coupled peptide receptor activity 5/2571 122/18639 0.040983606557377 0.29711919199648 0.999905513886686 1 GO:0001653 peptide receptor activity 5/2571 128/18639 0.0390625 0.283191729871645 0.999953645582667 1 GO:0098960 postsynaptic neurotransmitter receptor activity 1/2571 69/18639 0.0144927536231884 0.10506823601035 0.999965050884372 1 GO:0003823 antigen binding 4/2571 174/18639 0.0229885057471264 0.166659960568141 0.999999978279333 1 GO:0003730 mRNA 3'-UTR binding 10/2571 262/18639 0.0381679389312977 0.276706423080692 0.999999986669122 1 GO:0045182 translation regulator activity 7/2571 356/18639 0.0196629213483146 0.142550443800559 1 1 GO:0030371 translation repressor activity 3/2571 329/18639 0.00911854103343465 0.0661067624745968 1 1