category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	37/772	203/9376	2.21363485540723	ACTN1/COL6A2/LAMB1/LAMC3/FLNB/VCL/FLNA/PDGFC/PIP5K1A/COL4A1/TLN1/COL4A5/RAP1B/ITGA1/HGF/COL4A2/COL4A6/PARVB/FN1/CAPN2/ACTN4/TLN2/CAV2/COL6A6/ZYX/ITGA6/ITGA5/ITGB3/MYLK/PIP5K1C/JUN/SHC3/PTEN/PPP1R12B/FYN/ITGB5/VEGFA	5.23629915833606
NA	NA	hsa04518	Integrin signaling	29/772	154/9376	2.2870600901689	ACTN1/COL6A2/LAMB1/LAMC3/FLNB/VCL/FLNA/PDGFC/COL4A1/TLN1/COL4A5/ITGA1/HGF/FBN1/COL4A2/COL4A6/PARVB/FN1/MTOR/ACTN4/TLN2/COL6A6/ITGA6/ITGA5/ITGB3/MADCAM1/ITGB5/VEGFA/LIMS1	4.82381576660513
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	28/772	170/9376	2.00036574215178	GADD45A/WNT5A/BAX/WNT5B/GSTM5/GSTM3/WNT2/HGF/LRP5/RPS6KB2/AXIN2/IGF2/MTOR/TGFB2/GSTM2/TXNRD2/DPF1/MAP2K2/SMARCD3/SMARCB1/LEF1/SHC3/PTEN/TGFBR2/SMARCA4/BCL2L1/LRP6/PLCG1	3.94268312156514
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	35/772	233/9376	1.82436789788521	LMOD1/COL6A2/VCAN/CSRP1/FBLN1/SYNPO2/VCL/SYNE1/FHL3/TPM4/PDLIM7/FMNL2/TPM1/COL4A1/TLN1/COL4A5/ITGA1/CAPZB/COL27A1/FBN1/COL4A2/COL4A6/FN1/TLN2/COL5A1/COL6A6/ZYX/FHL2/ITGA6/ITGA5/ITGB3/SPTAN1/COL5A3/TMOD1/ITGB5	3.81679433976794
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	26/772	158/9376	1.99855709319866	IRS1/WNT5A/WNT5B/LPIN3/IKBKB/TBC1D7/WNT2/LRP5/RPS6KB2/TSC1/MTOR/FLCN/MAP2K2/PRKAA1/ATP6V1C1/RPTOR/LPIN2/DEPDC5/TTI1/PTEN/STRADA/ULK2/CASTOR2/LRP6/SLC3A2/RHEB	3.79164073231814
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	19/772	109/9376	2.11703189618292	IRS1/PRKAG2/SOCS3/IRS2/STAT3/IKBKB/RPS6KB2/TBC1D4/MTOR/NR1H3/PRKAA1/PPP1R3B/PPARGC1B/PRKCZ/PTEN/SLC27A5/OGT/PRKCE/ACACB	3.51360817815037
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	18/772	101/9376	2.1644692966706	PIM1/BAX/STAT3/COL4A1/COL4A5/PLCD3/COL4A2/COL4A6/FN1/TGFB2/STAT5B/PRKCZ/JUN/AGER/TGFBR2/PRKCE/PLCG1/VEGFA	3.52432424313067
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	22/772	138/9376	1.93617181046782	IRS1/PRKAG2/PRKAR2B/SOCS3/IRS2/SORBS1/IKBKB/PHKA2/RPS6KB2/TSC1/PRKAR1B/MTOR/MAP2K2/PRKAA1/RPTOR/PPP1R3B/PRKCZ/SHC3/ACACB/TRIP10/INPPL1/RHEB	3.3185641059427
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	16/772	89/9376	2.18338475868894	COL6A2/LAMB1/LAMC3/COL4A1/COL4A5/ITGA1/COL4A2/COL4A6/FN1/CD44/COL6A6/ITGA6/ITGA5/CD47/ITGB3/ITGB5	3.35990764213628
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	34/772	250/9376	1.65173056994819	CTSH/GALNS/CTSF/TPCN1/ACP2/MTOR/GAA/SLC36A1/GGA2/GUSB/GPR155/GNPTG/VPS16/ATP6V1C1/RPTOR/ATP6V0A2/VPS33A/TTI1/ABCA2/AP3S2/GGA3/MCOLN1/LAPTM4B/OSBPL1A/IGF2R/CLCN7/SLC29A3/IDUA/ABCA5/GGA1/VPS39/AP1B1/ARSG/BLOC1S5	3.12854172893755
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	17/772	99/9376	2.08551839639923	PDGFC/PIP5K1A/PLPP1/CHKB/RPS6KB2/TSC1/PLA2G4C/MTOR/SLC22A5/MAP2K2/PIP5K1C/JUN/CHPT1/PCYT1A/SLC44A2/PLCG1/RHEB	3.25233366380373
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	31/772	224/9376	1.68079200592154	BAX/CD4/LTBR/MAP3K1/CHEK2/IKBKB/TLN1/VAC14/RELB/CRTC1/ANAPC7/TLN2/TGFB2/IL1R1/STAT5B/ANAPC1/MAP2K2/FDPS/JUN/PTEN/ATR/MAD1L1/TGFBR2/BCL2L1/ANAPC2/ATF4/SRF/ETS1/NFKB2/RANBP3/ADCY6	3.08904715840504
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	10/772	45/9376	2.69890616004606	ABCA8/ABCC1/ABCB8/ABCA6/ABCC10/ABCD4/DEFB1/ABCC5/ABCA2/ABCA5	3.42180802686599
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	14/772	78/9376	2.17988574465258	PIP5K1A/ITPK1/PLCD3/IP6K1/IMPA2/INPP5B/PIP5K1C/PTEN/PI4KA/IPPK/MTMR14/PPIP5K2/PLCG1/INPPL1	3.13427119909621
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	17/772	103/9376	2.00452739071382	COL6A2/COL7A1/COL4A1/COL4A5/COL27A1/COL8A1/COL4A2/COL4A6/COL23A1/COL16A1/COL5A1/SLC36A1/COL6A6/SLC15A1/DPP4/COL5A3/SLC3A2	3.07053712893814
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	14/772	80/9376	2.12538860103627	BAX/PDGFC/STAT3/GAS6/HGF/RPS6KB2/MTOR/MAP2K2/SHC3/PTEN/BCL2L1/BCL2L11/PLCG1/VEGFA	3.02791399575247
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	44/772	362/9376	1.47619729195889	FGF10/LPAR1/COL6A2/IRS1/LAMB1/LAMC3/TLR4/PDGFC/IKBKB/COL4A1/COL4A5/NTRK1/ITGA1/HGF/RPS6KB2/COL4A2/COL4A6/IGF2/FN1/TSC1/IFNAR2/ANGPT1/MTOR/COL6A6/ITGA6/MAP2K2/ITGA5/GNB5/PRKAA1/RPTOR/OSMR/SGK3/ITGB3/F2R/PTEN/BCL2L1/PPP2R5B/ATF4/GNG4/BCL2L11/ITGB5/MAGI1/RHEB/VEGFA	2.76774781915197
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	31/772	235/9376	1.6021166354316	MT-ND2/MT-ND1/MT-CYB/MT-ATP6/MT-ND4/MT-ATP8/MT-ND5/MGLL/MT-ND6/MT-CO1/PRKAG2/MT-CO2/COX10/MAP3K5/NDUFAF5/RPS6KB2/MT-ND4L/TSC1/MTOR/DPF1/SMARCD3/PRKAA1/RPTOR/SMARCB1/NDUFV3/NDUFAF1/SMARCA4/NDUFB7/NDUFS2/RHEB/ADCY6	2.80002423529838
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	7/772	29/9376	2.93157048418796	RASSF1/FRMD6/NF2/TEAD1/TEAD4/TEAD3/RASSF4	3.12045213704365
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	20/772	137/9376	1.77300404674558	CTSH/RIPK1/GADD45A/BAX/ITPR3/IKBKB/CASP10/MAP3K5/NTRK1/CTSF/CAPN2/PARP1/MAP2K2/JUN/SPTAN1/BCL2L1/DFFB/ATF4/BCL2L11/EIF2AK3	2.7300691977187
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	15/772	93/9376	1.95888350325923	LAMB1/LAMC3/GADD45A/BAX/TRAF5/IKBKB/COL4A1/COL4A5/COL4A2/COL4A6/FN1/ITGA6/PTEN/BCL2L1/FHIT	2.78360260082399
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	8/772	37/9376	2.62596275031508	NANS/PMM2/PGM3/UAP1/PGM2/GPI/GMDS/GMPPB	2.968283335176
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	32/772	253/9376	1.53613631243728	ACTN1/RIPK1/VCL/BAX/U2AF1/ITPR3/TLR4/TRAF5/IKBKB/TNIP1/TLN1/PLCD3/RPS6KB2/ACTR3B/CD44/CAPN2/IRF3/MTOR/ACTN4/TLN2/NOD1/IL1R1/ARPC5L/ITGA5/RPTOR/GLMN/JUN/BCL2L1/ELMO2/CGAS/PRKCE/PLCG1	2.58946910369981
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	21/772	149/9376	1.71172236325069	LPAR1/PDGFC/PIP5K1A/PLPP1/TSC1/PLA2G4C/MTOR/DNM1/AGPAT3/MAP2K2/DNM3/DNM2/RALB/PIP5K1C/F2R/SHC3/FYN/PLCG1/MRAS/RHEB/ADCY6	2.62311646553169
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	14/772	87/9376	1.95438032279197	GADD45A/BAX/MLH1/RPS6KB2/AXIN2/MTOR/TGFB2/MAP2K2/LEF1/RALB/JUN/TGFBR2/BCL2L11/MSH2	2.6788025824905
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	23/772	169/9376	1.65288039979152	IRS1/IRS2/RPS6KB2/DAPK3/TSC1/MTOR/MAP2K2/VPS16/PRKAA1/RPTOR/VPS33A/GORASP1/TANK/PTEN/VMP1/BCL2L1/ULK2/ATG2B/MTMR14/VPS39/EIF2AK3/MRAS/RHEB	2.56544080994135
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	10/772	54/9376	2.24908846670505	MLH1/REV3L/FAN1/FANCL/RAD51C/ERCC1/TOP3A/ATR/PMS2/FANCM	2.7572720374438
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	9/772	47/9376	2.32565318046522	IRS1/CACNA1C/SOCS3/IRS2/IKBKB/CACNA1D/MTOR/PRKCZ/PRKCE	2.72901163987911
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	15/772	98/9376	1.85894046737866	ITPR3/PIP5K1A/ITPK1/PLCD3/IP6K1/IMPA2/INPP5B/PIP5K1C/PTEN/PI4KA/IPPK/MTMR14/PPIP5K2/PLCG1/INPPL1	2.56031267051367
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	16/772	108/9376	1.79927077336404	NUP42/POM121C/EIF4A3/THOC3/RAE1/ACIN1/NUP107/SNUPN/DDX39B/NDC1/NUP205/UPF2/NUP43/RANGAP1/NUP98/THOC2	2.50240088671742
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	26/772	204/9376	1.54790206237936	WNT5A/WNT5B/FLNA/ITPR3/TLR4/TIMP3/STAT3/TWIST2/WNT2/HGF/RPS6KB2/IGF2/FN1/CD44/MTOR/TGFB2/CAV2/MAP2K2/ITGA5/DROSHA/ITGB3/PPP1R12B/ITGB5/PLCG1/MRAS/VEGFA	2.36990034059042
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	15/772	103/9376	1.76870063886513	SMG6/PABPN1/DAZAP1/RNGTT/SYMPK/EIF4A3/ACIN1/ETF1/MSI2/DDX39B/SSU72/UPF2/PPP2R5B/RNMT/PELO	2.34968590652029
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	15/772	103/9376	1.76870063886513	GNA14/ACTN1/LAMB1/LAMC3/VCL/TLR4/COL4A1/COL4A5/COL4A2/COL4A6/FN1/ACTN4/TGFB2/IL1R1/RAB5A	2.34968590652029
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	15/772	104/9376	1.75169390195297	GDPD5/LPIN3/PEMT/PLPP1/CHKB/PLA2G4C/PGS1/AGPAT3/LPCAT1/LPIN2/PISD/ADPRM/PNPLA6/CHPT1/PCYT1A	2.30895289400211
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	38/772	333/9376	1.38592478488852	COL6A2/LAMB1/LAMC3/WNT5A/BAX/WNT5B/NFX1/IKBKB/COL4A1/COL4A5/ITGA1/WNT2/RPS6KB2/AXIN2/COL4A2/COL4A6/FN1/TSC1/IFNAR2/IRF3/MTOR/COL6A6/ITGA6/MAP2K2/ITGA5/ATP6V1C1/ATP6V0A2/ITGB3/PRKCZ/PTEN/ATR/PPP2R5B/ITGB5/HES6/MAGI1/RHEB/VEGFA/JAG1	2.14789283660104
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	5/772	21/9376	2.89168517147792	UST/CSGALNACT2/XYLT2/CHST11/CHPF2	2.59944539244674
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	28/772	232/9376	1.46578524209398	FGF10/LPAR1/ACTN1/VCL/PDGFC/PIP5K1A/LIMK2/SSH1/ITGA1/ACTR3B/GSN/BDKRB2/FN1/ACTN4/ARPC5L/ITGA6/MAP2K2/ITGA5/ITGB3/MYLK/PIP5K1C/INSRR/F2R/C6/PPP1R12B/SPATA13/ITGB5/MRAS	2.15181879002609
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	14/772	98/9376	1.73501110288675	PIP5K1A/ASAP1/PLPP1/LIMK2/RPS6KB2/ACTR3B/GSN/PLA2G4C/ARPC5L/DNM2/PIP5K1C/PRKCE/PLCG1/INPPL1	2.19090648439499
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	14/772	99/9376	1.71748573821113	CACNB2/CACNA1C/PRKAG2/TPM4/TPM1/CACNA2D3/ITGA1/CACNA1D/TGFB2/ITGA6/ITGA5/PRKAA1/ITGB3/ITGB5	2.14966694937975
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	6/772	30/9376	2.42901554404145	PIGL/PIGQ/MPPE1/GPAA1/PIGG/PIGZ	2.34816591302271
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	27/772	227/9376	1.44456871561936	MT-ND2/MT-ND1/MT-CYB/MT-ATP6/MT-ND4/MT-ATP8/CYP1B1/MT-ND5/MT-ND6/MT-CO1/MT-CO2/GSTM5/IKBKB/GSTM3/MAP3K5/HGF/MT-ND4L/EPHX1/AKR1A1/GSTM2/MAP2K2/NDUFV3/JUN/PTEN/NDUFB7/NDUFS2/VEGFA	2.03099615102342
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	34/772	300/9376	1.37644214162349	FGF10/CACNB2/GADD45A/CACNA1C/MAP3K1/FLNA/PDGFC/CDC25B/IKBKB/CACNA2D3/RAP1B/MAP3K5/NTRK1/RELB/HGF/IGF2/CACNA1D/PLA2G4C/ANGPT1/TGFB2/IL1R1/IL1RAP/MAP2K2/CACNA1H/JUN/ECSIT/MAP3K10/TGFBR2/ATF4/SRF/NFKB2/IRAK1/MRAS/VEGFA	1.98497804129491
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	19/772	149/9376	1.54870118579824	MT-ND2/MT-ND1/MT-ND4/GRIA4/MT-ND5/MGLL/MT-ND6/CACNA1C/ITPR3/GNAO1/MT-ND4L/CACNA1D/GNB5/NDUFV3/NDUFB7/GNG4/NDUFS2/GABRE/ADCY6	2.02228732640957
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	17/772	130/9376	1.58820247110403	ACTA2/COL4A1/COL4A5/GNAO1/COL4A2/COL4A6/MAP2K2/GNB5/PRKCZ/JUN/SHC3/EDNRB/TGFBR2/ATF4/GNG4/VEGFA/ADCY6	2.0228592410449
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	9/772	56/9376	1.95188749074759	ALG12/GANAB/MAN2A1/ALG8/ALG6/B4GALT2/SRD5A3/ALG13/MAN2A2	2.14000981100068
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	9/772	56/9376	1.95188749074759	BOC/MGRN1/SUFU/GRK3/GLI2/MEGF8/CUL3/EVC/MOSMO	2.14000981100068
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	6/772	31/9376	2.35066020391108	SGTA/BAG6/HSPA5/SRPRA/SRPRB/SEC11C	2.25621969262903
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	40/772	368/9376	1.32011714350079	MT-ND2/MT-ND1/MT-CYB/MT-ATP6/MT-ND4/MT-ATP8/MT-ND5/MT-ND6/MT-CO1/BAX/NEFM/MT-CO2/ITPR3/MAP3K5/POM121C/DNAH1/MT-ND4L/HSPA5/MTOR/TOMM40/HAP1/NDUFV3/RAE1/SLC1A2/PSMD4/NUP107/UBQLN4/TANK/NDC1/RAB5A/BCL2L1/NUP205/NUP43/ATF4/ULK2/NDUFB7/ATG2B/NUP98/NDUFS2/EIF2AK3	1.8765612364535
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	11/772	75/9376	1.7812780656304	BAX/MLH1/REV3L/GSTM5/GSTM3/MAP3K5/GSTM2/XPA/ERCC1/BCL2L1/MSH2	2.03477095007682
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	4/772	17/9376	2.85766534593112	CA8/CA4/CA3/CA13	2.29626128746146
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	14/772	105/9376	1.61934369602763	RIPK1/GADD45A/LTBR/TLR4/TRAF5/IKBKB/RELB/IL1R1/PARP1/CARD11/BCL2L1/NFKB2/IRAK1/PLCG1	1.91164466006511
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	11/772	77/9376	1.73501110288675	GADD45A/BAX/STAT3/IKBKB/RPS6KB2/MTOR/TGFB2/RALB/TGFBR2/BCL2L1/VEGFA	1.93983694196755
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	24/772	205/9376	1.42186275748768	MT-ND2/MT-ND1/MT-CYB/MT-ATP6/MT-ND4/MT-ATP8/MT-ND5/IRS1/MT-ND6/MT-CO1/MT-CO2/MT-ND4L/TBC1D4/MTOR/PDK3/TGFB2/PARP1/NDUFV3/PRKCZ/PTEN/AGER/TGFBR2/NDUFB7/NDUFS2	1.82929546781905
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	11/772	78/9376	1.71276737079846	VCL/ACTR3B/FN1/DNM1/CAV2/ARPC5L/ITGA5/DNM3/DNM2/SHC3/ELMO2	1.89340896105744
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	6/772	34/9376	2.14324900944834	NPAS2/PRKAG2/NFIL3/PRKAA1/RORB/BHLHE40	2.00034289654271
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	19/772	157/9376	1.46978647569387	MT-CYB/IRS1/MT-CO1/BAX/PRKAG2/MT-CO2/SOCS3/IRS2/IKBKB/MAP3K5/NR1H3/PRKAA1/NDUFV3/JUN/ATF4/NDUFB7/BCL2L11/NDUFS2/EIF2AK3	1.77808499199592
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	28/772	250/9376	1.36024870466321	PSD/LDLR/PIP5K1A/GRK4/ASAP1/CAPZB/ACAP3/ACTR3B/DNM1/CAV2/ARPC5L/DNM3/GRK5/DNM2/PIP5K1C/ARFGEF2/PRKCZ/ZFYVE16/WASHC2A/WASHC1/CHMP7/TGFBR2/RAB5A/GRK3/IGF2R/AGAP3/WASHC2C/AGAP9	1.72932367653732
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	10/772	70/9376	1.73501110288675	EGLN3/RAP1B/HGF/TGFB2/FLCN/MAP2K2/EPAS1/JUN/ETS1/VEGFA	1.8488661996271
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	18/772	148/9376	1.47710404705223	FGF10/GADD45A/WNT5A/BAX/WNT5B/WNT2/LRP5/RPS6KB2/AXIN2/MTOR/MAP2K2/LEF1/JUN/SHC3/PTEN/LRP6/NFKB2/JAG1	1.75240406842452
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	17/772	138/9376	1.49613276263423	MT-ND2/MT-ND1/MT-CYB/MT-ATP6/MT-ND4/MT-ATP8/MT-ND5/MT-ND6/MT-CO1/MT-CO2/COX10/MT-ND4L/ATP6V1C1/ATP6V0A2/NDUFV3/NDUFB7/NDUFS2	1.75870322033877
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	12/772	90/9376	1.61934369602763	IRS1/BAX/PRKAG2/IRS2/RPS6KB2/TSC1/MTOR/PRKAA1/RPTOR/ATF4/RHEB/ADCY6	1.76840903078414
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	9/772	62/9376	1.76299515293331	IRS1/PRKAG2/IRS2/RPS6KB2/MTOR/CLPB/PRKAA1/RPTOR/ADCY6	1.80548379371142
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	18/772	150/9376	1.45740932642487	FGF10/GADD45A/WNT5A/BAX/MLH1/WNT5B/WNT2/HGF/LRP5/RPS6KB2/AXIN2/MTOR/TGFB2/MAP2K2/LEF1/SHC3/TGFBR2/LRP6	1.69156233879684
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	3/772	12/9376	3.03626943005181	COQ4/COQ5/COQ6	2.11416680401915
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	9/772	63/9376	1.73501110288675	GADD45A/WNT5A/BAX/WNT5B/WNT2/AXIN2/LEF1/SUFU/GLI2	1.75332917824734
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	17/772	142/9376	1.45398817777129	MAP3K1/KLHL13/SOCS3/UBE2G2/MGRN1/ERCC8/FANCL/ANAPC7/HERC2/ANAPC1/MID1/PPIL2/UBE2A/FBXW8/ANAPC2/WWP2/CUL3	1.6328183340963
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	15/772	122/9376	1.49324726068122	IRS1/CACNA1C/MAP3K1/ITPR3/SOCS3/IRS2/STAT3/CACNA1D/MTOR/STAT5B/MAP2K2/SHC3/ATF4/PLCG1/ADCY6	1.64257019174699
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	4/772	20/9376	2.42901554404145	NANS/UAP1/GMDS/GMPPB	1.91624454523595
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	9/772	65/9376	1.68162614587485	LDLR/CACNA1C/ITPR3/CACNA1D/SCARB1/KCNA4/CACNA1H/ATF4/ADCY6	1.65176722068856
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	6/772	38/9376	1.91764385055904	PMM2/PGM3/UAP1/PGM2/GPI/GMPPB	1.69778663161178
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	13/772	105/9376	1.50367628916852	CACNB2/CACNA1C/TPM4/TPM1/CACNA2D3/ITGA1/CACNA1D/TGFB2/ITGA6/ITGA5/ITGB3/ITGB5/ADCY6	1.5546296745506
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	14/772	116/9376	1.46578524209398	GRIA4/HOMER1/CACNA1C/ITPR3/GNAO1/CACNA1D/PLA2G4C/SHANK2/DLG4/GNB5/SLC1A2/GRK3/GNG4/ADCY6	1.51200529844398
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	10/772	77/9376	1.57728282080614	GADD45A/BAX/IKBKB/TGFB2/STAT5B/MAP2K2/SHC3/CTBP2/TGFBR2/BCL2L1	1.52356139569162
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	16/772	138/9376	1.40812495306751	CD4/TLR4/ARHGEF28/PIP5K1A/IKBKB/ACTR3B/FN1/IRF3/ARPC5L/MAP2K2/ITGA5/PIP5K1C/JUN/ELMO2/IRAK1/PLCG1	1.44673104321798
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	20/772	180/9376	1.34945308002303	BAX/TRAF5/SOCS3/IKBKB/SRSF6/TSC1/IFNAR2/IRF3/MTOR/ITGA5/ITGB3/CARD9/BCL2L1/CGAS/PILRB/EIF2B5/MAVS/EIF2B2/IRAK1/RHEB	1.41797877900876
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	9/772	68/9376	1.60743675708625	PIM1/STAT3/IKBKB/RPS6KB2/MTOR/PPARD/STAT5B/MAP2K2/LEF1	1.50581432690085
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	7/772	49/9376	1.73501110288675	GALNT8/FUT10/XXYLT1/POMT2/GALNT15/B4GALT2/OGT	1.54513004915056
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	19/772	170/9376	1.35739103931728	ACTN1/PRKAG2/MAP3K1/MAP3K5/SYMPK/ACTR3B/CACNA1D/ACTN4/NF2/ARPC5L/PRKAA1/WHAMM/PRKCZ/JUN/AMOTL2/RAB13/PRKCE/ARHGEF18/MAGI1	1.40856444712305
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	39/772	388/9376	1.22076812136104	MT-ND2/MT-ND1/MT-CYB/MT-ATP6/MT-ND4/MT-ATP8/MT-ND5/IRS1/WNT5A/MT-ND6/MT-CO1/CACNA1C/MT-CO2/WNT5B/ITPR3/IRS2/IKBKB/MAP3K5/WNT2/LRP5/AXIN2/MT-ND4L/CAPN2/CACNA1D/MTOR/MAP2K2/ADAM17/NDUFV3/IDE/PSMD4/AGER/SLC39A7/ATF4/ULK2/NDUFB7/ATG2B/NDUFS2/LRP6/EIF2AK3	1.33034652778031
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	11/772	89/9376	1.50107702159865	CACNA1C/GNAO1/NSF/CACNA1D/GNB5/HAP1/GPHN/GNG4/SLC38A5/GABRE/ADCY6	1.42267550921764
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	4/772	23/9376	2.11218742960126	RXYLT1/POMT2/B4GALT2/POMK	1.59959677748025
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	4/772	23/9376	2.11218742960126	MLH1/MLH3/PMS2/MSH2	1.59959677748025
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	14/772	120/9376	1.41692573402418	IRS1/BAX/MAP3K1/IKBKB/RAP1B/MAP3K5/NTRK1/ZNF274/MAP2K2/JUN/SHC3/ATF4/IRAK1/PLCG1	1.37683449941566
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	13/772	110/9376	1.43532736693358	FST/RPS6KB2/FBN1/TGFB2/SKIL/GDF7/ACVR1C/EMP3/ZFYVE16/LTBP1/TGFBR2/ACVR2A/SMAD6	1.37565728434435
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	47/772	480/9376	1.18920552677029	MT-ND2/MT-ND1/MT-CYB/MT-ATP6/MT-ND4/GRIA4/MT-ATP8/MT-ND5/WNT5A/MT-ND6/MT-CO1/CACNA1C/BAX/NEFM/MT-CO2/WNT5B/ITPR3/UBE2G2/MAP3K5/WNT2/LRP5/DNAH1/AXIN2/MT-ND4L/HSPA5/CAPN2/CACNA1D/MTOR/DLG4/MAP2K2/TOMM40/HAP1/NDUFV3/PSMD4/TANK/AGER/MAP3K10/RAB5A/BCL2L1/ATF4/ULK2/NDUFB7/ATG2B/NDUFS2/LRP6/EIF2AK3/PLCG1	1.27467989891121
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	9/772	70/9376	1.56150999259808	IRS1/PRKAG2/SOCS3/IRS2/STAT3/IKBKB/MTOR/PRKAA1/ACACB	1.41243695774131
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	14/772	122/9376	1.39369744330247	IRS1/PRKAG2/IRS2/PFKFB3/RPS6KB2/TSC1/MTOR/PRKAA1/RPTOR/TBC1D1/STRADA/PPP2R5B/ACACB/RHEB	1.31105783343332
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	17/772	154/9376	1.34069039768522	MTHFD1L/COX10/GCLC/COQ4/AKR1A1/PMM2/RDH11/NADK/GUSB/COQ5/CTPS1/GPHN/COQ6/DHODH/DHRS3/GMPPB/CPOX	1.27688499118115
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	15/772	133/9376	1.36974560754217	IRS1/GADD45A/HOMER1/PRKAG2/BCL6/IRS2/STAT3/IKBKB/TGFB2/MAP2K2/PRKAA1/SGK3/PTEN/TGFBR2/BCL2L11	1.28637163426352
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	17/772	155/9376	1.33204078221628	WNT5A/LDLR/CACNA1C/WNT5B/ITPR3/RAP1B/WNT2/AXIN2/CACNA1D/SCARB1/MAP2K2/KCNA4/LEF1/CACNA1H/RBBP5/ATF4/ADCY6	1.24856844225063
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	15/772	134/9376	1.35952362539633	ACTA2/KCNMA1/CACNA1C/ITPR3/GUCY1A1/ARHGEF11/CACNA1D/PLA2G4C/KCNMB3/RAMP1/MAP2K2/MYLK/PPP1R12B/PRKCE/ADCY6	1.25557002530261
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	18/772	166/9376	1.31693613833573	IRS1/KCNMA1/CACNA1C/ITPR3/GUCY1A1/IRS2/BDKRB2/CACNA1D/KCNMB3/ADRA2C/MAP2K2/PDE3A/MYLK/EDNRB/PRKCE/ATF4/SRF/ADCY6	1.23407080593319
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	9/772	73/9376	1.49733834906665	GADD45A/BAX/RASSF1/STAT3/HGF/STAT5B/MAP2K2/FHIT/PLCG1	1.27775019367983
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	8/772	63/9376	1.54223209145489	KMT5A/SETDB2/SMYD3/DOT1L/PLOD1/DLST/PRDM2/CAMKMT	1.29346528725352
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	8/772	63/9376	1.54223209145489	XPC/ERCC8/UVSSA/ERCC5/CDK7/XPA/ERCC1/GTF2H2C	1.29346528725352
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	17/772	157/9376	1.31507210983136	GADD45A/ITPR3/CHEK2/TSC1/CAPN2/CACNA1D/MTOR/TGFB2/MAP2K2/PTEN/ATR/HUS1/TGFBR2/ETS1/HIPK3/MRAS/RHEB	1.19250982919459
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	17/772	157/9376	1.31507210983136	WNT5A/WNT5B/RASSF1/WNT2/AXIN2/FRMD6/TGFB2/NF2/DLG4/GDF7/LEF1/PRKCZ/TEAD1/TGFBR2/TEAD4/GLI2/TEAD3	1.19250982919459
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	3/772	17/9376	2.14324900944834	CYP39A1/CYP7B1/SLC27A5	1.4131708103803
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	8/772	65/9376	1.4947787963332	MGLL/LPIN3/PLPP1/AKR1A1/AGPAT3/LPIN2/AGK/PNPLA3	1.1989848133334
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	22/772	214/9376	1.24855939179701	RIPK1/BAX/CD4/ITPR3/TLR4/TRAF5/IKBKB/LIMK2/GNAO1/RPS6KB2/IRF3/MTOR/MAP2K2/GNB5/JUN/ATR/BCL2L1/CGAS/GNG4/AP1B1/IRAK1/PLCG1	1.10175748088478
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	10/772	86/9376	1.41221833955898	CACNB2/CACNA1C/CACNA2D3/ITGA1/CACNA1D/ITGA6/ITGA5/ITGB3/LEF1/ITGB5	1.15030435955327
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	24/772	238/9376	1.22471371968477	FGF10/SYNGAP1/RGL1/RASSF1/PDGFC/IKBKB/RAP1B/NTRK1/HGF/IGF2/PLA2G4C/ANGPT1/MAP2K2/GNB5/RALB/SHC3/RAB5A/BCL2L1/GNG4/ETS1/KSR1/PLCG1/MRAS/VEGFA	1.05180826189118
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	23/772	227/9376	1.23055853552761	RIPK1/BAX/ITPR3/TRAF5/STAT3/IKBKB/AKAP13/GNAO1/RPS6KB2/ARHGEF11/TSC1/IRF3/MTOR/IL1R1/MAP2K2/GNB5/ITGB3/CGAS/ATF4/GNG4/RHEB/VEGFA/ADCY6	1.05329835813973
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	15/772	140/9376	1.30125832716506	ACTA2/PRKAG2/HDAC4/ITPR3/RPS6KB2/MTOR/MAP2K2/GNB5/PRKAA1/MYLK/PRKCE/GNG4/MRAS/ADCY6/JAG1	1.07573476323995
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	10/772	87/9376	1.39598594485141	MT-CYB/CACNB2/MT-CO1/CACNA1C/MT-CO2/TPM4/TPM1/CACNA2D3/CACNA1D/ASPH	1.11147322127796
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	5/772	37/9376	1.64122671894693	GADD45A/BAX/NTRK1/MAP2K2/LEF1	1.17059421167608
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	18/772	174/9376	1.25638735036627	ERP29/BAX/DNAJC5/UBE2G2/MAP3K5/HSPA5/CAPN2/GANAB/NPLOC4/PDIA6/UBQLN4/PPP1R15A/UGGT1/ATF4/UBXN2A/BAG2/UGGT2/EIF2AK3	1.02252560357227
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	6/772	47/9376	1.55043545364348	AKR1A1/ACYP2/ME2/ACYP1/ME3/ACACB	1.13313556074149
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	15/772	142/9376	1.28293074509232	ITPR3/SOCS3/FOSL2/IKBKB/RELB/IFNAR2/TGFB2/IL1R1/FHL2/ITGB3/FOSB/JUN/TGFBR2/FYN/NFKB2	1.01759149353663
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	12/772	110/9376	1.32491756947715	EGLN3/LTBR/TLR4/STAT3/PFKFB3/RPS6KB2/ANGPT1/MTOR/MAP2K2/EPAS1/PLCG1/VEGFA	1.02675654051151
NA	NA	hsa04517	IgSF CAM signaling	29/772	299/9376	1.17795068189301	PPFIA2/ACTN1/NLGN4X/VCL/CNTN1/EPB41L3/SORBS1/NLGN2/RAP1B/ACTR3B/CLMP/SRGAP1/ACTN4/NRP2/IL1RAP/ARPC5L/MAP2K2/ITGA5/KCNA4/PVR/ITGB3/MYLK/SPTAN1/KCNQ3/FYN/PTPRZ1/MAGI1/PLCG1/NCAM2	0.936716500434016
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	3/772	19/9376	1.91764385055904	GALNS/GUSB/IDUA	1.19929695730194
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	10/772	90/9376	1.34945308002303	CD4/TLR4/STAT3/IKBKB/RPS6KB2/MTOR/MAP2K2/JUN/PTEN/PLCG1	0.997791672881552
Organismal Systems	Endocrine system	hsa04924	Renin secretion	8/772	69/9376	1.40812495306751	KCNMA1/CACNA1C/ITPR3/GUCY1A1/CACNA1D/PDE3A/AQP1/ADCY6	1.01919415557851
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	7/772	59/9376	1.44094142443137	GADD45A/BAX/MLH1/AXIN2/MAP2K2/LEF1/PTEN	1.01768399931096
Human Diseases	Substance dependence	hsa05032	Morphine addiction	10/772	91/9376	1.3346239252975	PDE4D/GRK4/GNAO1/GNB5/PDE3A/GRK5/GRK3/GNG4/GABRE/ADCY6	0.960795187374638
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	21/772	212/9376	1.20305015152996	FGF10/LPAR1/PDGFC/TLN1/RAP1B/P2RY1/HGF/GNAO1/ANGPT1/SIPA1L3/TLN2/MAP2K2/ITGB3/RALB/F2R/PRKCZ/MAGI1/PLCG1/MRAS/VEGFA/ADCY6	0.895721081181099
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	16/772	157/9376	1.2377149269001	ATP8A2/MFGE8/GAS6/NR1H3/PPARD/MAP2K2/VPS16/CD47/ADAM17/ITGB3/VPS33A/AGER/RAB5A/ANO6/ITGB5/VPS39	0.899722247793931
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	8/772	71/9376	1.3684594614318	IKBKB/NOD1/ATP6V1C1/ADAM17/ATP6V0A2/JUN/PTPRZ1/PLCG1	0.933479502556607
Organismal Systems	Immune system	hsa04611	Platelet activation	13/772	126/9376	1.2530635743071	ITPR3/GUCY1A1/TLN1/RAP1B/P2RY1/PLA2G4C/TLN2/ITGB3/MYLK/F2R/PRKCZ/FYN/ADCY6	0.856619845327819
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	5/772	41/9376	1.48110703904967	XRCC3/RAD51C/RAD52/TOP3A/UIMC1	0.924741963629137
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	4/772	31/9376	1.56710680260739	PGP/PCCA/AMT/MCEE	0.947327486337122
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	26/772	275/9376	1.14826189354687	MT-ND2/MT-ND1/MT-CYB/MT-ATP6/MT-ND4/MT-ATP8/MT-ND5/MT-ND6/MT-CO1/CACNA1C/BAX/MT-CO2/ITPR3/MT-ND4L/HSPA5/CACNA1D/CAV2/NDUFV3/C6/PSMD4/FYN/ATF4/NDUFB7/NDUFS2/EIF2AK3/NCAM2	0.747472844912082
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/772	12/9376	2.02417962003454	CD46/NCAM2	1.06335955452363
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	4/772	32/9376	1.51813471502591	SUCLA2/PCCA/MCEE/ACACB	0.879418004511944
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	4/772	32/9376	1.51813471502591	MTOR/RPTOR/ULK2/ATG2B	0.879418004511944
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	6/772	53/9376	1.37491445889139	PTH1R/BDKRB2/DNM1/DNM3/DNM2/ADCY6	0.81985371679529
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	8/772	75/9376	1.29547495682211	GADD45A/BAX/CHEK2/ZNF385A/GORAB/PTEN/ATR/BCL2L1	0.76953889410899
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	10/772	97/9376	1.2520698680626	GRIA4/CACNA1C/ITPR3/GUCY1A1/GNAO1/CACNA1D/GNB5/CACNA1H/GNG4/ADCY6	0.747481246841921
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	9/772	86/9376	1.27099650560308	KCNMA1/CACNA1C/ITPR3/VAMP2/CACNA1D/KCNMB3/ATF4/TRPM4/ADCY6	0.756221720150627
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	25/772	268/9376	1.13293635449695	MT-ND2/MT-ND1/MT-CYB/MT-ATP6/MT-ND4/MT-ATP8/MT-ND5/MT-ND6/MT-CO1/BAX/MT-CO2/ITPR3/UBE2G2/MAP3K5/MT-ND4L/HSPA5/NDUFV3/PSMD4/BCL2L1/SLC39A7/ATF4/NDUFB7/NDUFS2/EIF2AK3/PLCG1	0.661368853702918
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	15/772	154/9376	1.1829621156046	CACNB2/CACNA1C/PRKAG2/ITPR3/GUCY1A1/CACNA2D3/GNAO1/CACNA1D/PLA2G4C/MAP2K2/PRKAA1/MYLK/JUN/PPP1R12B/ADCY6	0.685729861943816
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	2/772	13/9376	1.8684734954165	POLL/POLM	0.938566007057062
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	5/772	44/9376	1.38012246820537	ALG12/MAN2A1/B4GALT2/ALG13/MAN2A2	0.757018688848157
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	5/772	44/9376	1.38012246820537	CDK7/TAF1/TAF4B/GTF2H2C/TAF3	0.757018688848157
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	5/772	44/9376	1.38012246820537	TDG/PARP1/POLL/POLG2/PNKP	0.757018688848157
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	5/772	44/9376	1.38012246820537	VAMP2/NSF/AQP3/RAB5A/ADCY6	0.757018688848157
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	10/772	99/9376	1.22677552729366	ITPR3/NTRK1/BDKRB2/PLA2G4C/IL1R1/IL1RAP/PRKCE/HTR2A/PLCG1/ADCY6	0.679444663481103
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	14/772	144/9376	1.18077144502015	RIPK1/PRKAG2/LPIN3/TLR4/IKBKB/MAP3K5/ACADVL/IRF3/C2/PRKAA1/LPIN2/LEF1/IRAK1/ACACB	0.654797880942451
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	9/772	88/9376	1.24211022138483	BDKRB2/C2/CD55/CFI/F2R/C6/F2RL2/CD59/CD46	0.683498309951395
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	4/772	34/9376	1.42883267296556	POLR1A/POLR3B/POLR3A/CRCP	0.750328567164913
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	11/772	112/9376	1.19282013323464	LAMB1/LAMC3/LDLR/TLR4/STAT3/IKBKB/GNAO1/TGFB2/ITGA6/BCL2L1/IRAK1	0.614902422855261
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	3/772	24/9376	1.51813471502591	HS3ST3B1/NDST1/XYLT2	0.761272514969421
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	15/772	158/9376	1.15301370761461	GADD45A/CHEK2/CDC25B/ANAPC7/TGFB2/MAU2/ANAPC1/CDK7/CDC7/ATR/MAD1L1/DBF4B/PPP2R5B/FBXO5/ANAPC2	0.5810113516255
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	8/772	79/9376	1.22988128812225	VAMP2/NSF/DNM1/DNM3/ATP6V1C1/DNM2/ATP6V0A2/SLC1A2	0.614596156073761
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	4/772	35/9376	1.3880088823094	PFKFB3/PMM2/GMDS/GMPPB	0.688847507377916
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	19/772	205/9376	1.12564134967775	ACTN1/BAX/LTBR/HDAC4/TRAF5/STAT3/SND1/VAC14/GSN/IRF3/ACTN4/STAT5B/JUN/MAD1L1/GTF2H2C/ATF4/SRF/NFKB2/MRPS18B	0.544810243276526
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	20/772	217/9376	1.11936200186242	FGF10/CYP1B1/CACNA1C/CHRNA3/BCL6/GSTM5/STAT3/GSTM3/RPS6KB2/EPHX1/CACNA1D/MTOR/GSTM2/STAT5B/MAP2K2/JUN/ATF4/VEGFA/ADCY6/JAG1	0.532863556190828
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	12/772	125/9376	1.1659274611399	BAX/ABCC1/MAP3K5/S1PR3/BDKRB2/MAP2K2/PRKCZ/PTEN/CERS4/PPP2R5B/PRKCE/FYN	0.559400720789065
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	4/772	36/9376	1.34945308002303	GBE1/GAA/PGM2/GPI	0.629231958805102
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	23/772	254/9376	1.09975113214475	FGF10/GNA14/CACNA1C/ITPR3/PDGFC/PLCD3/NTRK1/PHKA2/ORAI2/HGF/BDKRB2/CACNA1D/TPCN1/MYLK/CACNA1H/F2R/EDNRB/MCOLN1/HTR2A/ASPH/STIM2/PLCG1/VEGFA	0.482762742031129
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	11/772	115/9376	1.16170308628069	CACNA1C/CHRNA3/ITPR3/GNAO1/CACNA1D/GNB5/KCNQ3/FYN/ATF4/GNG4/ADCY6	0.522615606432733
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	9/772	93/9376	1.17533010195554	CACNA1C/MAP3K1/ITPR3/CACNA1D/PLA2G4C/MAP2K2/JUN/ATF4/ADCY6	0.508976665202086
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	6/772	59/9376	1.2350926495126	GSTM5/GSTM3/GCLC/GGT7/GSTM2/GSTK1	0.542589138847924
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	3/772	26/9376	1.40135512156238	ABCC1/SCARB1/ABCD4	0.613837993097674
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	15/772	163/9376	1.11764518897613	BAX/MAP3K1/TLR4/STAT3/IKBKB/CASP10/IRF3/TGFB2/STAT5B/MAP2K2/JUN/TGFBR2/ATF4/MAVS/IRAK1	0.453849149381878
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	11/772	117/9376	1.14184491386564	MORF4L2/DPF1/SMARCD3/SMARCB1/SS18L1/SS18/SMARCA4/INO80/MTA1/SRCAP/BICRAL	0.462454217240033
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	8/772	83/9376	1.17060990074287	EED/SFMBT2/CBX8/OGT/PHC2/CBX6/PCGF6/L3MBTL2	0.467637570348842
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	8/772	83/9376	1.17060990074287	RIPK1/GSDME/IKBKB/IRF3/POLR3B/POLR3A/CGAS/MAVS	0.467637570348842
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	5/772	49/9376	1.23929364491911	DLG4/GPSM1/FOSB/JUN/ATF4	0.503039749852929
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	7/772	72/9376	1.18077144502015	RIPK1/MAP3K1/IKBKB/CASP10/IRF3/TANK/MAVS	0.461217008401576
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	4/772	38/9376	1.27842923370603	NMRK1/NAMPT/BST1/NADK	0.515138232058135
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	13/772	142/9376	1.11187331241334	GSTM5/IKBKB/GSTM3/MAP3K5/GSTM2/CAV2/IL1R1/PRKAA1/ITGB3/PRKCZ/JUN/ACVR2A/VEGFA	0.402364652976954
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	27/772	308/9376	1.06466590404414	MT-ND2/MT-ND1/MT-CYB/MT-ATP6/MT-ND4/GRIA4/MT-ATP8/MT-ND5/MT-ND6/MT-CO1/BAX/MT-CO2/MAP3K5/DNAH1/MT-ND4L/MTOR/DLG4/HAP1/NDUFV3/SLC1A2/PSMD4/TAF4B/MAP3K10/ULK2/NDUFB7/ATG2B/NDUFS2	0.345651975642033
Human Diseases	Cancer: specific types	hsa05218	Melanoma	7/772	73/9376	1.1645964937185	FGF10/GADD45A/BAX/PDGFC/HGF/MAP2K2/PTEN	0.422877508083849
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	4/772	39/9376	1.24564899694433	MTHFD1L/DMGDH/BHMT2/AMT	0.460455544416858
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	10/772	109/9376	1.11422731378048	CD4/STAT3/IKBKB/MTOR/IL1R1/STAT5B/IL1RAP/JUN/TGFBR2/PLCG1	0.359300415000439
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	5/772	51/9376	1.19069389413797	PLA2G7/PLPP1/PLA2G4C/LPCAT1/CHPT1	0.409017173141958
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	8/772	86/9376	1.12977467164719	RPS6KB2/MTOR/STAT5B/MAP2K2/JUN/SHC3/BTC/PLCG1	0.362139080747988
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	2/772	17/9376	1.42883267296556	CSAD/GGT7	0.530080333299144
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/772	17/9376	1.42883267296556	TXNRD2/KYAT1	0.530080333299144
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	9/772	98/9376	1.1153642804272	LDLR/CACNA1C/ITPR3/CACNA1D/SCARB1/CACNA1H/PRKCE/ATF4/ADCY6	0.343875553801602
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	5/772	52/9376	1.16779593463531	CYP1B1/LDLR/PLA2G4C/SCARB1/ADCY6	0.363434424617929
Human Diseases	Cancer: specific types	hsa05214	Glioma	7/772	76/9376	1.11862557949277	GADD45A/BAX/MTOR/MAP2K2/SHC3/PTEN/PLCG1	0.311019598478627
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	16/772	183/9376	1.06186471870665	RIOK1/RRP7A/MDN1/UTP18/UTP14A/HEATR1/DROSHA/NOP56/RBM28/POP5/UTP6/GNL2/POP1/RCL1/UTP4/REXO1	0.253153563383799
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	4/772	41/9376	1.18488563123973	RASSF1/DAPK3/MAP2K2/VEGFA	0.355371025161394
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	9/772	100/9376	1.09305699481865	CD4/ITGA1/CD44/CD55/IL1R1/ITGA6/ITGA5/ITGB3/CD59	0.280228783087798
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/772	18/9376	1.34945308002303	ACSF3/ACACB	0.444506066274893
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	2/772	18/9376	1.34945308002303	MAN2C1/GBA2	0.444506066274893
Human Diseases	Infectious disease: viral	hsa05162	Measles	12/772	136/9376	1.07162450472417	BAX/TLR4/STAT3/IKBKB/IFNAR2/IRF3/STAT5B/JUN/BCL2L1/CD46/MAVS/IRAK1	0.252022426085154
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	16/772	184/9376	1.05609371480063	BOC/SEMA3A/WNT5A/EFNB2/ABLIM1/WNT5B/LIMK2/SSH1/SRGAP1/GDF7/EPHB4/PRKCZ/SEMA3F/ABLIM2/FYN/PLCG1	0.230177141953372
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	3/772	30/9376	1.21450777202073	ABCC1/IKBKB/ABCC5	0.352480307466063
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	7/772	78/9376	1.08994287232629	TLR4/IRF3/C2/NOD1/ITGA5/JUN/IRAK1	0.238925977005758
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	2/772	19/9376	1.27842923370603	DLST/AMT	0.363887724637527
NA	NA	hsa04519	Cadherin signaling	34/772	404/9376	1.02211050120556	MYO1E/ACTN1/CDH3/LHFPL2/WNT5A/CDH13/VCL/WNT5B/LIMA1/IKBKB/LHFPL6/WNT2/LRP5/ACTR3B/AXIN2/ACTN4/NF2/ARPC5L/MAP2K2/LEF1/PCDHA10/TEAD1/AMOTL2/PCDHGA6/PCDHB13/ATN1/PCDHGA10/TEAD4/TEAD3/LRP6/SCN5A/MRAS/GABRE/PCDHGA7	0.136078252968621
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	16/772	187/9376	1.03915103488404	RIPK1/ITPR3/TLR4/TRAF5/IKBKB/NAMPT/IFNAR2/IRF3/NOD1/JUN/TANK/CARD6/CARD9/BCL2L1/CARD8/MAVS	0.161984705749508
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	3/772	31/9376	1.17533010195554	TKT/PGM2/GPI	0.29288138319117
NA	NA	hsa04981	Folate transport and metabolism	3/772	31/9376	1.17533010195554	ABCC1/ABCC5/BHMT2	0.29288138319117
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	9/772	103/9376	1.06122038331908	GNA14/TLR4/IKBKB/GNAO1/BDKRB2/TGFB2/JUN/TGFBR2/IRAK1	0.187132239266749
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	10/772	116/9376	1.04698945863856	PGP/TKT/DLST/GPI/SUCLA2/PCCA/ME2/AMT/MCEE/ME3	0.152534481584491
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	3/772	32/9376	1.13860103626943	GAA/PGM2/B4GALT2	0.235244316206945
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	3/772	32/9376	1.13860103626943	BAX/BCL2L1/BCL2L11	0.235244316206945
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	9/772	105/9376	1.04100666173205	TOMM40/JUN/FKBP8/RAB5A/BCL2L1/ATF4/RABGEF1/EIF2AK3/MRAS	0.126569732492559
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	8/772	93/9376	1.04473786840493	ACTN1/VCL/SORBS1/RAP1B/ACTN4/LEF1/TGFBR2/FYN	0.129872342598435
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	6/772	69/9376	1.05609371480063	GRIA4/CACNA1C/CACNA1D/FOSB/JUN/ATF4	0.140080595072152
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	9/772	106/9376	1.03118584416854	ZEB1/PDGFC/IKBKB/MTOR/MAP2K2/LEF1/INSRR/PTEN/ATF4	0.0967196369154851
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	18/772	216/9376	1.01208981001727	LDLR/BAX/TLR4/STAT3/IKBKB/RAP1B/MAP3K5/HSPA5/IRF3/JUN/TANK/MIB2/AGER/BCL2L1/ATF4/EIF2AK3/IRAK1/PLCG1	0.0538446678812679
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	3/772	33/9376	1.1040979745643	VAMP2/STX5/STX8	0.179432109328087
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	6/772	70/9376	1.04100666173205	CYP1B1/GSTM5/GSTM3/EPHX1/GSTM2/GSTK1	0.103149232083929
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	10/772	119/9376	1.02059476640397	RIPK1/TRAF5/SOCS3/IKBKB/CASP10/MAP3K5/ADAM17/JUN/ATF4/JAG1	0.0677234862782762
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	12/772	144/9376	1.01208981001727	WNT5A/WNT5B/STAT3/WNT2/AXIN2/SKIL/MAP2K2/MEIS1/TBX3/ACVR1C/ACVR2A/PCGF6	0.043792214967489
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/772	22/9376	1.1040979745643	HNMT/CARNMT1	0.146419535461655
Organismal Systems	Nervous system	hsa04730	Long-term depression	5/772	60/9376	1.01208981001727	ITPR3/GUCY1A1/GNAO1/PLA2G4C/MAP2K2	0.028140023064258
NA	NA	hsa03272	Virion - Hepatitis viruses	4/772	48/9376	1.01208981001727	LDLR/SCARB1/DPP4/CHMP7	0.0251530071216948
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	8/772	99/9376	0.98142042183493	BAX/RPS6KB2/MTOR/MAP2K2/JUN/SHC3/ADCY6/JAG1	-0.055666479468219
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	2/772	23/9376	1.05609371480063	FDPS/DHDDS	0.0806764426964924
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/772	23/9376	1.05609371480063	CA4/AQP1	0.0806764426964924
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	26/772	323/9376	0.977622355186962	CYP1B1/IRS1/PIM1/ZEB1/HDAC4/RASSF1/ABCC1/TIMP3/CDC25B/TPM1/IRS2/STAT3/IKBKB/CD44/MTOR/TGFB2/MAP2K2/ITGA5/RPTOR/ITGB3/SLC7A1/PTEN/PRKCE/BCL2L11/PLCG1/VEGFA	-0.122592376689423
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	6/772	75/9376	0.97160621761658	ITPR3/HSPA5/TPO/ATF4/TTF1/ADCY6	-0.073949143202898
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	16/772	201/9376	0.966772355837393	GADD45A/BAX/ZEB1/WT1/BCL6/NFKBIZ/NTRK1/DOT1L/HOXA11/MEIS1/SS18L1/SS18/EWSR1/TGFBR2/BCL2L1/ETV6	-0.142639113382258
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	3/772	37/9376	0.984736031368156	FAH/TPO/FAHD1	-0.0278652039905421
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	4/772	50/9376	0.97160621761658	TLR4/HGF/TGFB2/GYPC	-0.0602982396619784
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	8/772	101/9376	0.961986354075822	WNT5A/WNT5B/WNT2/GNAO1/MAP2K2/LEF1/EDNRB/ADCY6	-0.115050190059466
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	6/772	76/9376	0.95882192527952	SORBS1/NR1H3/PPARD/SLC27A5/ANGPTL4/ME3	-0.107963124989133
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	7/772	89/9376	0.955230831926413	LPAR1/ITPR3/GUCY1A1/PDGFC/MAP2K2/HTR2A/ADCY6	-0.127110197117273
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	9/772	115/9376	0.950484343320568	CYP4X1/CACNA1C/ITPR3/GNAO1/CACNA1D/PLA2G4C/GNB5/HTR2A/GNG4	-0.160031917377981
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	9/772	115/9376	0.950484343320568	PDE4D/PTH1R/ITPR3/AKAP13/LRP5/ARHGEF11/ATF4/LRP6/ADCY6	-0.160031917377981
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	4/772	51/9376	0.952555115310373	ATP6V1C1/ATP6V0A2/KDELR3/PLCG1	-0.101763995661851
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	16/772	205/9376	0.947908504991786	RIPK1/GADD45A/BAX/TRAF5/STAT3/IKBKB/RELB/CD44/IFNAR2/IRF3/JUN/PSMD4/BCL2L11/NFKB2/MAVS/IRAK1	-0.225880891448989
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	5/772	65/9376	0.93423674770825	CACNA1C/ITPR3/CACNA1D/MAP2K2/CACNA1H	-0.159362408732085
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	6/772	78/9376	0.93423674770825	BTG2/PNPT1/MPHOSPH6/EXOSC10/CNOT10/TENT4A	-0.174694769007164
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	4/772	52/9376	0.93423674770825	LDLR/LRPAP1/SCARB1/ANGPTL4	-0.142438669980899
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	12/772	156/9376	0.93423674770825	RIPK1/LDLR/BAX/SOCS3/STAT3/IKBKB/IFNAR2/SCARB1/IRF3/NR1H3/MAP2K2/MAVS	-0.248098540284591
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	6/772	79/9376	0.92241096609169	CYP1B1/GSTM5/GSTM3/EPHX1/GSTM2/GSTK1	-0.207437161950145
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	8/772	105/9376	0.925339254872934	ITPR3/IKBKB/RELB/JUN/CARD9/KSR1/NFKB2/MRAS	-0.230445253021952
Organismal Systems	Digestive system	hsa04970	Salivary secretion	7/772	93/9376	0.914145634854309	KCNMA1/ITPR3/GUCY1A1/VAMP2/BST1/PRH1/ADCY6	-0.249231980005216
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	5/772	67/9376	0.906349083597556	CACNA1C/ITPR3/RAP1B/MAP2K2/ATF4	-0.23043158396647
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	4/772	54/9376	0.899635386682019	GCLC/KYAT1/MRI1/BHMT2	-0.221547591885559
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	2/772	27/9376	0.899635386682019	HSD17B12/ELOVL4	-0.156431426406975
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	19/772	248/9376	0.930469664048136	RIPK1/BAX/FLNA/TLR4/IKBKB/ACTR3B/FYCO1/NOD1/ARPC5L/MAP2K2/VPS16/DNM2/VPS33A/LEF1/JUN/RAB5A/ELMO2/VPS39/IRAK1	-0.332396498324549
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	4/772	55/9376	0.883278379651437	PLPP1/CERK/CERS4/GBA2	-0.260043190700284
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	7/772	95/9376	0.894900463594219	TLR4/ANGPT1/TGFB2/ATP6V1C1/ATP6V0A2/JUN/VEGFA	-0.308396403133999
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/772	28/9376	0.867505551443375	HSD17B12/ELOVL4	-0.210310731178312
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/772	28/9376	0.867505551443375	A4GALT/B4GALT2	-0.210310731178312
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	2/772	28/9376	0.867505551443375	ATP6V1C1/ATP6V0A2	-0.210310731178312
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/772	42/9376	0.867505551443375	CYP1B1/DLST/KYAT1	-0.257770085974618
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	8/772	109/9376	0.891381851024386	RIPK1/TLR4/IKBKB/IFNAR2/IRF3/MAP2K2/JUN/IRAK1	-0.341656865699544
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	6/772	83/9376	0.877957425557151	ABCD4/PEX26/PEX1/GSTK1/PEX6/PEX11G	-0.334515715342842
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/772	14/9376	0.867505551443375	B4GALT2	-0.148600909983795
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	4/772	57/9376	0.852286155804018	ACSF3/ACADVL/HSD17B12/ELOVL4	-0.335056509699327
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	5/772	71/9376	0.855287163394877	SOCS3/STAT3/STAT5B/MAP2K2/SHC3	-0.366625045270302
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	13/772	178/9376	0.887000058217384	WNT5A/WNT5B/SERPINF1/WNT2/LRP5/AXIN2/PPARD/LEF1/JUN/CTBP2/MCC/LRP6/CHD8	-0.455916810541355
Genetic Information Processing	Transcription	hsa03040	Spliceosome	18/772	243/9376	0.899635386682019	U2AF1/SRSF6/EIF4A3/DDX46/DHX16/DHX15/THOC3/ACIN1/SF3A2/CDC5L/SNRNP40/DDX39B/PRPF3/PRPF38B/SNRPD1/THOC2/PRPF40B/PHF5A	-0.474811371104579
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	2/772	30/9376	0.809671848013817	DLST/SUCLA2	-0.312748227719486
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/772	15/9376	0.809671848013817	SLC33A1	-0.220969139883475
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	4/772	59/9376	0.823395099675068	MGLL/IRS1/IRS2/ADCY6	-0.407600582078138
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	5/772	73/9376	0.83185463837036	ELL2/CD4/ELL/SMARCB1/BICD1	-0.431995177512134
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	14/772	193/9376	0.88099009369379	GRK4/STAT3/IKBKB/CXCL14/RAP1B/STAT5B/GNB5/GRK5/PRKCZ/SHC3/GRK3/GNG4/PLCG1/ADCY6	-0.500395693179931
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/772	31/9376	0.783553401303694	AKR1A1/GUSB	-0.361564719954781
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	4/772	60/9376	0.809671848013817	PLA2G4C/MAP2K2/PLCG1/VEGFA	-0.443004363097316
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/772	46/9376	0.792070286100473	COX10/GUSB/CPOX	-0.423446685180774
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/772	16/9376	0.759067357512953	A4GALT	-0.288909483824054
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	14/772	196/9376	0.867505551443375	BAX/ITPR3/STAT3/IKBKB/IFNAR2/IRF3/MTOR/MAP2K2/GNB5/LEF1/JUN/GNG4/PLCG1/VEGFA	-0.561498324334934
Organismal Systems	Digestive system	hsa04976	Bile secretion	6/772	90/9376	0.809671848013817	LDLR/EPHX1/SCARB1/SLC27A5/AQP1/ADCY6	-0.543443042923627
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	3/772	48/9376	0.759067357512953	ACSF3/PCCA/MCEE	-0.501263499068063
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/772	17/9376	0.71441633648278	NRP2	-0.353010143782017
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	12/772	173/9376	0.842433136661775	BAX/PABPN1/TLR4/SOCS3/IKBKB/IFNAR2/IRF3/MAP2K2/FDPS/RAE1/NUP98/MAVS	-0.626566711418055
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	14/772	200/9376	0.850155440414508	MYO1E/LPAR1/RIPK1/BAX/TLR4/IKBKB/ACTR3B/ARHGEF11/IL1R1/ARPC5L/F2R/JUN/FYN/IRAK1	-0.641613306872466
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	11/772	160/9376	0.834974093264249	CDH3/NLGN4X/VCAN/CNTN1/CD4/NLGN2/ITGA6/PVR/VSIR/MADCAM1/NCAM2	-0.630645024159082
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	9/772	133/9376	0.821847364525303	GRIA4/CACNA1C/ITPR3/GNAO1/CACNA1D/GNB5/PPP2R5B/ATF4/GNG4	-0.619805866977884
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/772	18/9376	0.674726540011514	ABCD4	-0.413749468608425
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	6/772	93/9376	0.783553401303694	CD4/IKBKB/STAT5B/JUN/PLCG1/JAG1	-0.628336302608866
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	8/772	122/9376	0.796398539029984	CD4/IKBKB/MAP2K2/JUN/CARD11/PPP2R5B/FYN/PLCG1	-0.67801631644869
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4/772	66/9376	0.736065316376197	CYP1B1/HSD17B12/CYP7B1/SRD5A3	-0.644521900969142
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	4/772	66/9376	0.736065316376197	TLR4/STAT3/TGFB2/JUN	-0.644521900969142
NA	NA	hsa04081	Hormone signaling	15/772	219/9376	0.83185463837036	GNA14/IRS1/PTH1R/IRS2/STAT3/VIPR2/GNAO1/IGF2/ADRA2C/STAT5B/RAMP1/GNB5/ITGB3/GNG4/ADCY6	-0.754178989680192
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/772	36/9376	0.674726540011514	AKR1A1/GUSB	-0.585693668410021
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/772	36/9376	0.674726540011514	GALNT8/GALNT15	-0.585693668410021
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	2/772	36/9376	0.674726540011514	PRIM2/RNASEH2A	-0.585693668410021
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	5/772	82/9376	0.740553519524833	CES1/GSTM5/GSTM3/GSTM2/GUSB	-0.706801501240472
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/772	20/9376	0.607253886010363	CYP2R1	-0.526654592200453
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4/772	68/9376	0.71441633648278	DHRS4L2/RDH11/RDH10/DHRS3	-0.707951843605666
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	10/772	154/9376	0.788641410403068	CACNB2/CACNA1C/TPM4/TPM1/CACNA2D3/CACNA1D/PPP2R5B/ATF4/SCN5A/ADCY6	-0.792157961149513
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	11/772	168/9376	0.795213422156427	RIPK1/BAX/TLR4/TRAF5/STAT3/CAPN2/PLA2G4C/IFNAR2/STAT5B/PARP1/CHMP7	-0.802264475041623
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	4/772	69/9376	0.704062476533754	PLA2G4C/MAP2K2/FYN/PLCG1	-0.739032965434206
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/772	21/9376	0.578337034295583	CSAD	-0.579425091390566
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	8/772	128/9376	0.759067357512953	PDE4D/GUCY1A1/PDE3A/PGM2/ADPRM/PDE9A/FHIT/ADCY6	-0.822092726300263
NA	NA	hsa04082	Neuroactive ligand signaling	13/772	199/9376	0.793397036998464	GRIA4/CHRNA3/P2RY1/GNAO1/ADRA2C/P2RY11/GNB5/SLC1A2/SLC17A9/HTR2A/GNG4/GABRE/ADCY6	-0.882382335909406
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	4/772	71/9376	0.684229730715902	NTRK1/MTOR/MAP2K2/PTEN	-0.799993227879271
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	3/772	56/9376	0.650629163582531	TLR4/NFKB2/HSF1	-0.785446835763856
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4/772	73/9376	0.665483710696288	GSTM5/GSTM3/GSTM2/GSTK1	-0.859431520310126
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/772	41/9376	0.592442815619866	DMGDH/AMT	-0.783370851774091
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	2/772	41/9376	0.592442815619866	GRIA4/GABRE	-0.783370851774091
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	2/772	42/9376	0.578337034295583	GCLC/SLC3A2	-0.820352098567267
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	3/772	59/9376	0.617546324756301	CTPS1/ASMTL/DHODH	-0.88269544254117
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	5/772	91/9376	0.66731196264875	IKBKB/MAP2K2/JUN/CARD11/INPPL1	-0.955236732998129
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/772	43/9376	0.564887335823593	PLPP1/SCARB1	-0.856582911670027
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	6/772	107/9376	0.68103239552564	PRKAG2/ITPR3/PHKA2/PRKAA1/ATF4/ACACB	-0.993953602286507
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	7/772	122/9376	0.696848721651236	PLCD3/TBC1D4/MTOR/MAP2K2/ITGB3/PLCG1/RHEB	-1.00952867476236
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	8/772	138/9376	0.704062476533754	ITPR3/ANAPC7/ANAPC1/MAD1L1/PPP2R5B/FBXO5/ANAPC2/ADCY6	-1.04904637374831
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/772	26/9376	0.467118373854125	PLA2G4C	-0.814996421818859
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/772	26/9376	0.467118373854125	NKX6-1	-0.814996421818859
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	4/772	78/9376	0.622824498472167	TLR4/TGFB2/JUN/IRAK1	-1.00193626103301
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	3/772	62/9376	0.58766505097777	ADAM17/CTBP2/JAG1	-0.97571270954788
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	6/772	110/9376	0.662458784738577	CDC25B/ANAPC7/ANAPC1/MAD1L1/ANAPC2/ADCY6	-1.06664792248557
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/772	28/9376	0.433752775721688	GPHN	-0.898814018722955
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	8/772	144/9376	0.674726540011514	KCND3/ITPR3/MAP3K5/MTOR/NOP56/PSMD4/ULK2/ATG2B	-1.17821911698244
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	3/772	67/9376	0.543809450158534	AKR1A1/PGM2/GPI	-1.1224739172735
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/772	30/9376	0.404835924006908	PLA2G4C	-0.977976762905036
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	2/772	50/9376	0.48580310880829	LTBR/MADCAM1	-1.09197031095889
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	5/772	102/9376	0.595346947068983	KCNMA1/ITPR3/RAP1B/BST1/ADCY6	-1.23081689468107
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/772	31/9376	0.391776700651847	CSAD	-1.01601082310073
Organismal Systems	Sensory system	hsa04742	Taste transduction	4/772	86/9376	0.564887335823593	CACNA1C/ITPR3/P2RY1/ADCY6	-1.21419147686257
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	3/772	70/9376	0.520503330866025	CD55/EIF4G3/FYN	-1.20613849357345
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/772	33/9376	0.368032658188099	DLST	-1.08931257925422
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	7/772	139/9376	0.611622619003243	ITPR3/GNAO1/MAP2K2/JUN/SHC3/ATF4/ADCY6	-1.38178331598633
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	8/772	155/9376	0.626842721042955	TLR4/SCARB1/ITGA5/ATP6V1C1/ATP6V0A2/ITGB3/RAB5A/ITGB5	-1.40317824633483
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	3/772	76/9376	0.47941096263976	ITPR3/MYLK/ADCY6	-1.36491129539241
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	4/772	94/9376	0.51681181788116	TRAF5/IKBKB/FOSB/JUN	-1.41027411920183
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/772	37/9376	0.328245343789385	RIMKLB	-1.22632461965716
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	13/772	238/9376	0.663386598162581	TLR4/STAT3/IKBKB/IFNAR2/IRF3/C2/ADAM17/C6/JUN/CGAS/MAVS/IRAK1/PLCG1	-1.57557250003501
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/772	38/9376	0.319607308426507	IRS1	-1.25883436727233
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/772	38/9376	0.319607308426507	CD4	-1.25883436727233
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	5/772	116/9376	0.523494729319278	ACTN1/VCL/RAP1B/ACTN4/PLCG1	-1.54680403948988
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	9/772	181/9376	0.603898892165002	BAX/TLR4/CASP10/TGFB2/ATP6V0A2/CARD9/RAB5A/KSR1/IRAK1	-1.61180895831579
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	2/772	63/9376	0.385558022863722	PLA2G4C/PTGDS	-1.4657180587094
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	8/772	168/9376	0.578337034295583	PIM1/SOCS3/STAT3/IFNAR2/MTOR/STAT5B/OSMR/BCL2L1	-1.65189155162185
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/772	43/9376	0.282443667911797	ACADVL	-1.412614577401
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	1/772	46/9376	0.264023428700158	PSMD4	-1.49880858124116
Cellular Processes	Cell motility	hsa04814	Motor proteins	9/772	194/9376	0.563431440628172	MYO1E/ACTA2/TPM4/TPM1/CAPZB/DNAH1/MYO19/KIF1C/MYO15B	-1.84047008960739
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	11/772	226/9376	0.591132101426017	GRIA4/PDE4D/CACNA1C/RAP1B/VIPR2/CACNA1D/MAP2K2/PDE3A/F2R/JUN/ADCY6	-1.86367755215274
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/772	48/9376	0.253022452504318	CACNA1D	-1.55409651144758
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/772	50/9376	0.242901554404145	L3HYPDH	-1.60780634660735
NA	NA	hsa04382	Cornified envelope formation	10/772	217/9376	0.55968100093121	KAZN/COL7A1/COL4A1/COL4A5/COL4A2/COL4A6/ITGA6/PPP2R5B/ELOVL4/GBA2	-1.96570050804462
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	5/772	133/9376	0.456581869180724	IFNAR2/MAP2K2/SHC3/FYN/PLCG1	-1.89059086780549
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	3/772	99/9376	0.368032658188099	C2/CFI/DEFB1	-1.89344433684152
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	1/772	54/9376	0.224908846670505	TPO	-1.71095740655024
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	3/772	100/9376	0.364352331606218	LTBR/CXCL14/TNFRSF10D	-1.91416854728346
Human Diseases	Substance dependence	hsa05034	Alcoholism	8/772	191/9376	0.508694354773079	HDAC4/GNAO1/GNB5/FOSB/SHC3/ATF4/SLC29A3/GNG4	-2.05481603025315
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	2/772	82/9376	0.296221407809933	CD4/HSPA5	-1.91728083799717
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	5/772	143/9376	0.424653067140114	ACTN1/ACTN4/C2/C6/SNRPD1	-2.07668435311302
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	14/772	298/9376	0.570574121083562	CD4/LTBR/CXCL14/TNFRSF10D/IFNAR2/TGFB2/IL1R1/GDF7/IL1RAP/ACVRL1/OSMR/ACVR1C/TGFBR2/ACVR2A	-2.25655198802326
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	2/772	85/9376	0.285766534593112	CTPS1/ASMTL	-1.98135600524219
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	7/772	195/9376	0.435977148930517	HDAC4/TLR4/MTOR/MAP2K2/ITGB3/AGER/PLCG1	-2.38403759125752
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	17/772	370/9376	0.558017084441955	GRIA4/LPAR1/QRFPR/PTH1R/CHRNA3/S1PR3/P2RY1/VIPR2/BDKRB2/ADRA2C/P2RY11/GAL/F2R/EDNRB/F2RL2/HTR2A/GABRE	-2.59827108723519
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/772	75/9376	0.161934369602763	TKT	-2.18266923648262
Genetic Information Processing	Translation	hsa03010	Ribosome	3/772	222/9376	0.164122671894693	MRPL48/MRPS25/MRPS18B	-3.77535388314498
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/772	449/9376	0.0540983417381169	GRK3/OR3A2	-6.15262544814871