category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	33/555	216/9376	2.58098098098098	CCL5/HSPA1B/ABCA1/HSPA1A/HSPA6/PIK3CD/ARHGEF1/ERN1/HSPA4/IL18/ATF4/CCL3L1/IRAK4/HSPA2/IRF3/VAV1/MAP2K6/MIB2/HSP90AA1/TANK/POU2F2/PPP3CA/NFATC2/CAMK2D/TAB1/NFATC3/DDIT3/PPP3CB/TNFSF10/ATF6/GSK3B/MIB1/ICAM1	5.89629227313741
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	23/555	133/9376	2.92146582672898	KIR2DL3/KIR2DL1/NCR1/PIK3CD/IFNAR2/SYK/ZAP70/TYROBP/PRKCB/PTPN6/KIR3DL2/KIR3DL1/KLRD1/BRAF/KIR2DL4/VAV1/MAP2K2/KLRK1/PPP3CA/NFATC2/PPP3CB/TNFSF10/ICAM1	5.59790118065797
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	9/555	41/9376	3.70837178642057	ATM/SYCP3/BABAM2/RAD51B/BARD1/BLM/RAD50/RAD51D/BRCA1	4.35929507628083
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	14/555	91/9376	2.5990297990298	PIK3CD/SYK/PRKCB/PTPN6/VAV1/MAP2K2/INPP5D/PPP3CA/NFATC2/NFATC3/PPP3CB/CD72/BANK1/GSK3B	3.84467397623988
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	17/555	133/9376	2.15934430671273	ATM/RBL2/PIK3CD/CCNG2/HOMER2/SIRT1/GADD45A/TGFBR1/BRAF/MAP2K2/SGK1/SGK3/S1PR4/FBXO32/BCL6/TNFSF10/STK11	3.3775749602502
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	19/555	157/9376	2.04445974637057	ABCA1/PECAM1/ATP11C/HAVCR1/CD24/PTPN6/SIRT1/VPS41/ATP8A1/MAP2K2/SGK1/NFATC2/ADAM10/VPS8/CAMK2D/MFGE8/NFATC3/XKR6/HAVCR2	3.3103418485069
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	12/555	82/9376	2.47224785761371	HSPA1B/HSPA1A/HSPA6/KIR2DL3/KIR2DL1/HSPA4/KIR3DL2/KIR3DL1/HSPA2/KLRD1/KIR2DL4/HSP90AA1	3.35861127704638
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	15/555	115/9376	2.20352526439483	ITPR2/ARHGEF1/VDR/PRKCB/ATF4/PLD1/MEF2A/BRAF/SLC34A2/SGK1/PRKACB/WNK1/STK39/ADCY9/TNFSF11	3.25722986574204
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	18/555	157/9376	1.93685660182475	ATM/ITPR2/RBL2/PIK3CD/E2F3/SIRT1/SQSTM1/GADD45A/TGFBR1/KIR2DL4/MAP2K6/MAP2K2/PPP3CA/NFATC2/RAD50/NFATC3/PPP3CB/MCU	2.96930123525326
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	10/555	67/9376	2.52144681995428	ITPR2/PRKCB/ATF4/BRAF/MAP2K2/PRKACB/PPP3CA/CAMK2D/PPP3CB/RPS6KA1	3.13484362408047
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	8/555	48/9376	2.81561561561562	PCCA/HADH/HIBCH/AUH/HMGCL/ABAT/ACAA2/ALDH6A1	3.16317688263645
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	16/555	138/9376	1.95868912390652	PIK3CD/ZAP70/ARHGEF1/IL18/IRAK4/FYB1/IRF3/VAV1/MAP2K6/MAP2K2/NFATC2/PKN2/TAB1/NFATC3/GSK3B/RPS6KA1	2.84578170733298
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	18/555	163/9376	1.86556126678826	STAT4/PIK3CD/E2F3/PRKCB/ATF4/IRAK4/SLC10A1/TGFBR1/BRAF/IRF3/CASP10/MAP2K6/MAP2K2/MAVS/NFATC2/TAB1/NFATC3/DDX3X	2.79617468278418
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	23/555	227/9376	1.71169583680597	CCL5/ITPR2/PIK3CD/E2F3/ARHGEF1/PRKCB/ATF4/CCL4L2/CCL3L1/IL10RB/IRF3/MAP2K6/MAP2K2/PRKACB/PPP3CA/NFATC2/NFATC3/CGAS/ADCY9/PPP3CB/GSK3B/RIPK1/GNG11	2.72266218115444
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	19/555	178/9376	1.8032594392145	CTBP2/LEF1/PRKCB/CCDC88C/TBL1XR1/SIRT1/NKD1/FRAT2/INVS/PRKACB/PPP3CA/NFATC2/CAMK2D/CACYBP/NFATC3/PPP3CB/GSK3B/LZTS2/LGR4	2.71389071368113
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	7/555	41/9376	2.884289167216	DAPK2/E2F3/RPS6KA5/BRAF/MAP2K2/RASSF1/CDH1	3.03288216563133
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	6/555	32/9376	3.16756756756757	PCCA/ACSS1/HIBCH/ABAT/ALDH6A1/ACACA	3.08073567122215
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	9/555	62/9376	2.45231037489102	HSPA1B/HSPA1A/HSPA6/PIK3CD/SIRT1/PRKACB/HDAC1/ADCY9/RPTOR	2.87779853070854
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	13/555	109/9376	2.01484420200017	CCL5/PIK3CD/IFNAR2/SPP1/CCL4L2/CCL3L1/IRAK4/IRF3/MAP2K6/MAP2K2/TLR1/TAB1/RIPK1	2.6731064943701
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	10/555	77/9376	2.19398619398619	PIK3CD/E2F3/CTBP2/MECOM/GADD45A/TGFBR1/BRAF/MAP2K2/HDAC1/POLK	2.63875921254784
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	8/555	57/9376	2.37104472893947	CBR4/ELOVL5/HADH/SCD5/TECR/ACAA2/HSD17B8/ACACA	2.60421966561271
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	13/555	116/9376	1.8932587760174	DLGAP1/ITPR2/GRIK4/SLC38A2/PRKCB/HOMER2/PLD1/PRKACB/PPP3CA/ADCY9/PPP3CB/SLC38A1/GNG11	2.42814161210319
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	6/555	37/9376	2.73951789627465	LEF1/GADD45A/BRAF/MAP2K2/CDH1/POLK	2.65921097315833
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	12/555	105/9376	1.93070785070785	ATM/SYK/ZAP70/PRKCB/CCL4L2/IRAK4/GADD45A/CFLAR/TAB1/ICAM1/RIPK1/TNFSF11	2.40556975624694
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	11/555	93/9376	1.99817882398528	CD3E/STAT4/MAML3/MAML2/ZAP70/IL2RA/RBPJ/PPP3CA/NFATC2/NFATC3/PPP3CB	2.426492034553
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	8/555	59/9376	2.2906703313483	PIK3CD/LEF1/GADD45A/BRAF/MAP2K2/GSK3B/CDH1/POLK	2.49445976824297
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	6/555	38/9376	2.6674253200569	NMRK2/ENPP3/CD38/SIRT1/SIRT5/QPRT	2.58335728429084
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	16/555	158/9376	1.71075379176645	PIK3CD/PRKCB/ATP6V1E2/BRAF/EIF4B/MAP2K2/SGK1/DEPTOR/STRADA/ULK2/MAPKAP1/GSK3B/FLCN/RPTOR/RPS6KA1/STK11	2.25996959115343
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	9/555	73/9376	2.08278415401703	PIK3CD/E2F3/PRKCB/FHIT/GADD45A/BRAF/MAP2K2/RASSF1/POLK	2.32951241734783
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	13/555	122/9376	1.80014768867228	CD3E/TEC1/PIK3CD/ZAP70/PTPN6/PPP2R3C/VAV1/MAP2K2/PPP3CA/NFATC2/NFATC3/PPP3CB/GSK3B	2.2313029598786
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	18/555	187/9376	1.626130943778	CCL5/ITPR2/TXNIP/IFNAR2/IL18/IRAK4/ANTXR2/IRF3/NLRP1/GBP3/HSP90AA1/TANK/MAVS/PKN2/TAB1/MCU/NLRP7/RIPK1	2.16932720987665
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	8/555	63/9376	2.14523094523094	MECOM/EZH2/HADH/ASH1L/NSD2/NSD1/EHMT1/SMYD3	2.28766151690388
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	14/555	137/9376	1.72636285920957	ATM/ITPR2/PIK3CD/ERN1/CTSF/ATF4/GADD45A/CASP10/CFLAR/MAP2K2/DDIT3/TNFSF10/DFFB/RIPK1	2.14819968338761
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	26/555	300/9376	1.46412012012012	HSPA1B/HSPA1A/HSPA6/MECOM/RPS6KA5/MAP2K5/PRKCB/ATF4/TAOK3/IRAK4/EFNA5/GADD45A/TGFBR1/BRAF/MAP2K6/MAP2K2/PRKACB/PPP3CA/TAB1/NFATC3/DDIT3/DUSP6/PPP3CB/RPS6KA1/MKNK1/RASA1	2.04935406929571
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	4/555	21/9376	3.21784641784642	ENPP3/DPYD/PPCDC/CSAD	2.55206915678656
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	5/555	31/9376	2.72478930543447	DPYD/HIBCH/CSAD/ABAT/ALDH6A1	2.41268410725461
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	15/555	154/9376	1.64548964548965	ITPR2/CD38/MAP2K5/PRKCB/EEF2/MAP2K2/PRKACB/PPP3CA/NFATC2/PIK3CG/CAMK2D/NFATC3/MYL6B/ADCY9/PPP3CB	2.02586406151377
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	10/555	90/9376	1.87707707707708	CD3E/PIK3CD/ZAP70/PTPN6/MAP2K6/MAP2K2/PPP3CA/NFATC2/NFATC3/PPP3CB	2.09709398408857
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	14/555	142/9376	1.66557543458952	ITPR2/TEC1/PIK3CD/IFNAR2/SYK/TYROBP/SQSTM1/TGFBR1/MAP2K6/PPP3CA/NFATC2/TAB1/PPP3CB/TNFSF11	2.00456313975061
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	18/555	196/9376	1.55146166574738	ITPR2/PIK3CD/E2F3/IFNAR2/SYK/LEF1/CD200R1/IRF3/MAP2K6/MAP2K2/PPP3CA/NFATC2/PIK3CG/NFATC3/PPP3CB/GSK3B/ICAM1/GNG11	1.95701990138569
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	4/555	23/9376	2.93803368585977	ST3GAL3/RXYLT1/FKTN/B3GALNT2	2.33411898481692
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	16/555	170/9376	1.58999470058294	DPF3/SMARCA2/PIK3CD/E2F3/LEF1/PRKCB/GADD45A/TGFBR1/BRAF/FRAT2/MGST1/MAP2K2/ARID2/GSK3B/MGST2/POLK	1.94719885224865
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	6/555	45/9376	2.25249249249249	ABCA1/DEFB1/ABCB1/ABCA7/ABCA10/ABCC4	2.11246981601932
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	19/555	214/9376	1.49990738401953	CD3E/ATM/ITPR2/PIK3CD/PRKCB/IRAK4/APOBEC3H/IRF3/MAP2K6/MAP2K2/PPP3CA/NFATC2/TAB1/NFATC3/CGAS/APOBEC3D/PPP3CB/RIPK1/GNG11	1.85555791245736
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	8/555	69/9376	1.95868912390652	PRKCB/ATF4/SIRT1/PRKACB/PPP3CA/CAMK2D/HDAC1/PPP3CB	2.00479840241391
NA	NA	hsa04517	IgSF CAM signaling	25/555	299/9376	1.41251619512489	NCAM1/CD96/MBP/PIK3CD/SRGAP3/PRKCB/PTPN6/GRIP1/TRIO/LMO7/CABLES1/VAV1/CSK/CD2/MAP2K2/INPP5D/MYL6B/GSK3B/SLAMF6/ICAM1/F11R/CASK/CDH1/TUBB4B/RASA1	1.81835488872809
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	16/555	174/9376	1.55344309827068	HSPA1B/HSPA1A/DNAJB1/ERP29/HSPA6/HSPH1/ERN1/DNAJA1/ATF4/EDEM3/NGLY1/HSP90AA1/ERO1B/DDIT3/BAG2/ATF6	1.848330816228
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	12/555	122/9376	1.66167478954364	PIK3CD/SIRT1/PPP2R3C/TBC1D1/EEF2/SCD5/STRADA/SREBF1/RPTOR/STK11/GYS1/ACACA	1.84515550977299
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	13/555	138/9376	1.59143491317404	PIK3CD/BRAF/MAP2K2/PRKACB/RHOQ/PHKB/SREBF1/GSK3B/RPTOR/MKNK1/PRKAR1B/GYS1/ACACA	1.75562089421689
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	13/555	139/9376	1.57998574113682	HSPA1B/HSPA1A/HSPA6/ITPR2/PIK3CD/KRT19/NCOA1/ATF4/KRT18/MAP2K2/HSP90AA1/PRKACB/ADCY9	1.72795514094125
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	9/555	87/9376	1.74762348555452	PIK3CD/LEF1/GADD45A/TGFBR1/BRAF/MAP2K2/MSH3/GSK3B/POLK	1.75724088504145
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	10/555	100/9376	1.68936936936937	CD3E/ITGA1/CD38/CD37/CD24/IL2RA/CD55/CD2/CD7/TFRC	1.73838045835406
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	19/555	224/9376	1.43294723294723	CD3E/ATM/PIK3CD/E2F3/ATF4/IL2RA/TGFBR1/MAP2K2/PRKACB/PPP3CA/ANAPC4/NFATC2/TRRAP/NFATC3/ADCY9/PPP3CB/VAC14/MSX1/ICAM1	1.64503139396431
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	4/555	27/9376	2.50276943610277	HADH/BDH1/HMGCL/ABAT	1.96139414500837
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	15/555	169/9376	1.49944026867104	DAPK2/PIK3CD/ERN1/SQSTM1/VPS41/IGBP1/CFLAR/C9orf72/MAP2K2/TANK/PRKACB/DEPTOR/ULK2/RPTOR/STK11	1.64339157049973
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	3/555	17/9376	2.98124006359301	SEPHS2/PAPSS1/SEPSECS	2.05078464591248
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	3/555	17/9376	2.98124006359301	CA3/CA13/CA1	2.05078464591248
Human Diseases	Cancer: specific types	hsa05214	Glioma	8/555	76/9376	1.7782835467046	PIK3CD/E2F3/PRKCB/GADD45A/BRAF/MAP2K2/CAMK2D/POLK	1.70874158937625
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	4/555	28/9376	2.41338481338481	ELOVL5/HADH/TECR/ACAA2	1.87868212445627
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	3/555	18/9376	2.81561561561562	CBR4/HSD17B8/ACACA	1.93393494178287
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	8/555	78/9376	1.73268653268653	PIK3CD/ITPKB/PLCH2/INPP5D/PIK3CG/PPIP5K2/INPP5F/ALDH6A1	1.62983619435034
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	9/555	93/9376	1.63487358326068	LEF1/RADIL/PTPN6/CCM2/LMO7/TGFBR1/PTPRM/SMURF2/CDH1	1.54332636168295
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	9/555	93/9376	1.63487358326068	ITPR2/PRKCB/ATF4/PLD1/MAP2K6/MAP2K2/PRKACB/CAMK2D/ADCY9	1.54332636168295
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	10/555	107/9376	1.5788498779153	ITPR2/ATF4/SIRT1/PRKACB/PPP3CA/PHKB/CAMK2D/PPP3CB/GYS1/ACACA	1.51047872456417
Human Diseases	Infectious disease: viral	hsa05162	Measles	12/555	136/9376	1.4906200317965	HSPA1B/HSPA1A/CD3E/HSPA6/PIK3CD/IFNAR2/IRAK4/RACK1/IL2RA/IRF3/MAVS/GSK3B	1.44561272877515
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	4/555	31/9376	2.17983144434757	PCCA/ACSS1/GRHPR/AMT	1.6503816240324
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	10/555	109/9376	1.54988015538474	CD3E/RORA/ZAP70/IL2RA/TGFBR1/HSP90AA1/PPP3CA/NFATC2/NFATC3/PPP3CB	1.44838804969983
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	6/555	56/9376	1.81003861003861	GLI1/PRKACB/DISP1/SPOP/GSK3B/SMURF2	1.52498297712113
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	10/555	110/9376	1.53579033579034	PIK3CD/SPDYA/BRAF/HSP90AA1/PRKACB/ANAPC4/ADCY9/RPS6KA1/STK10/AURKA	1.41781082937619
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	5/555	45/9376	1.87707707707708	KIR2DL3/KIR2DL1/KIR3DL2/KIR3DL1/KLRD1	1.47928938716484
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	12/555	140/9376	1.44803088803089	ITPR2/SPP1/MEF2A/TGFBR1/MAP2K2/PRKACB/PIK3CG/ADCY9/PRKCE/GNG11/SLC9A1/CDH1	1.33968665261323
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	13/555	156/9376	1.40780780780781	PIK3CD/E2F3/IFNAR2/CLDN3/BRAF/IRF3/CLDN4/CFLAR/MAP2K2/MAVS/GSK3B/CLDN12/RIPK1	1.28832547295925
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	6/555	59/9376	1.71800274851122	ENPP3/NT5C3B/DPYD/TK2/CTPS2/AK9	1.38767346405036
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	9/555	100/9376	1.52043243243243	CCL5/IL18/CCL4L2/CCL3L1/IL2RA/CXCL14/IL10RB/TNFSF10/CCL18	1.31237274331151
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	4/555	34/9376	1.98749337572867	RORA/DBP/NFIL3/CLOCK	1.44686142084597
Human Diseases	Cancer: specific types	hsa05218	Melanoma	7/555	73/9376	1.61994323090213	PIK3CD/E2F3/GADD45A/BRAF/MAP2K2/CDH1/POLK	1.33375192930145
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	6/555	60/9376	1.68936936936937	PIK3CD/PRKCB/MAP2K2/PPP3CA/NFATC2/PPP3CB	1.34364978368823
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	12/555	144/9376	1.40780780780781	LEF1/IRAK4/SIRT1/SCD5/IRF3/MAP2K6/TAB1/SREBF1/GSK3B/TRA2B/RIPK1/ACACA	1.23697836358843
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	10/555	116/9376	1.45635290462877	TXK/PIK3CD/PECAM1/PRKCB/CLDN3/CLDN4/VAV1/ICAM1/F11R/CLDN12	1.24050220079975
NA	NA	hsa03272	Virion - Hepatitis viruses	5/555	48/9376	1.75975975975976	CLDN3/SLC10A1/CLDN4/EPCAM/CLDN12	1.32365820593288
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	8/555	89/9376	1.51853426460168	SLC38A2/GABRP/PRKCB/PRKACB/ABAT/ADCY9/SLC38A1/GNG11	1.23284352626823
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	16/555	205/9376	1.31853219072731	CD3E/PIK3CD/E2F3/IFNAR2/SYK/IRAK4/GADD45A/IRF3/RBPJ/MAP2K6/MAVS/HDAC1/TAB1/ICAM1/RIPK1/POLK	1.15663180684625
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	6/555	62/9376	1.63487358326068	MAML3/CTBP2/MAML2/RBPJ/HDAC1/NRARP	1.258021905428
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	4/555	36/9376	1.87707707707708	ENPP3/AGL/GYS1/GBE1	1.32247902169363
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	8/555	90/9376	1.50166166166166	PIK3CD/ATF4/SIRT1/PRKACB/EHMT1/ADCY9/RPTOR/STK11	1.19947457323194
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	11/555	133/9376	1.39722278669647	ITPR2/PRKCB/ATF4/PPP2R3C/PRKACB/PPP3CA/CLOCK/CAMK2D/PPP3CB/GSK3B/GNG11	1.15724873984244
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	12/555	148/9376	1.36975894813733	PIK3CD/E2F3/LEF1/NCOA1/GADD45A/BRAF/FRAT2/MAP2K2/BRCA1/GSK3B/POLK/TNFSF11	1.13728412284861
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	10/555	119/9376	1.41963812552048	CCL5/PIK3CD/RPS6KA5/ATF4/CASP10/CFLAR/MAP2K6/TAB1/ICAM1/RIPK1	1.15554405075165
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	7/555	77/9376	1.53579033579034	PIK3CD/E2F3/PLD1/GADD45A/TGFBR1/BRAF/POLK	1.18411895521231
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	15/555	193/9376	1.31298137515754	CCL5/PIK3CD/FGR/PRKCB/CCL4L2/CCL3L1/CXCL14/BRAF/VAV1/PRKACB/PIK3CG/ADCY9/GSK3B/CCL18/GNG11	1.10199107061465
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	5/555	50/9376	1.68936936936937	PECAM1/KLRB1/IL18/KLRK1/ICAM1	1.22592103764689
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	10/555	120/9376	1.40780780780781	PIK3CD/RPS6KA5/MAP2K5/ATF4/IRAK4/BRAF/MAP2K2/CAMK2D/GSK3B/RPS6KA1	1.12773667735353
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	26/555	362/9376	1.21335921556916	ITGA1/RBL2/PIK3CD/IFNAR2/SYK/SPP1/PHLPP1/ATF4/COL1A2/EFNA5/PPP2R3C/IL2RA/EIF4B/MAP2K2/HSP90AA1/SGK1/SGK3/PIK3CG/PKN2/BRCA1/GSK3B/RPTOR/STK11/COL9A2/GNG11/GYS1	1.03843695036434
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	12/555	150/9376	1.3514954954955	PIK3CD/E2F3/LEF1/GADD45A/TGFBR1/BRAF/FRAT2/MAP2K2/ABCB1/GSK3B/CDH1/POLK	1.08850865584665
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	4/555	38/9376	1.7782835467046	PIK3CD/PRKCB/SGK1/SCNN1A	1.20580181039498
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	9/555	109/9376	1.39489213984627	PIK3CD/PRKCB/TBC1D4/SREBF1/GSK3B/PRKCE/RPS6KA1/SLC27A4/GYS1	1.04014856814307
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	20/555	275/9376	1.22863226863227	MT-ATP8/CCL5/HSPA1B/NCAM1/HSPA1A/HSPA6/ITPR2/MT-ND4L/PIK3CD/UQCRC2/NDUFV3/ATF4/MT-ND2/PRKACB/PPP3CA/DDIT3/PPP3CB/MCU/GSK3B/TUBB4B	0.965233828417843
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	14/555	184/9376	1.28538973756365	PIK3CD/SRGAP3/RGS3/SSH2/EFNA5/PPP3CA/NFATC2/CAMK2D/NFATC3/PPP3CB/GSK3B/EFNB2/LRIG2/RASA1	0.980653255676061
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/555	27/9376	1.87707707707708	ELOVL5/SCD5/TECR	1.14474902295151
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	6/555	68/9376	1.4906200317965	PIK3CD/LEF1/BRAF/MAP2K2/PIM2/DUSP6	1.01846184626245
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	5/555	54/9376	1.56423089756423	AMD1/MTAP/AHCYL2/AHCY/GCLC	1.0429714347512
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	16/555	217/9376	1.24561796819861	PIK3CD/PAQR8/VDR/PRKCB/UGT2B7/ATF4/KLF5/MGST1/MAP2K2/HSP90AA1/PRKACB/ADCY9/BCL6/RPS6KA1/MGST2/TNFSF11	0.91820402166187
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	11/555	142/9376	1.30866641289176	HERC4/HERC1/UBE2Q1/COP1/ANAPC4/FBXW8/WWP1/BRCA1/PPIL2/SMURF2/HERC2	0.929633639714288
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	7/555	83/9376	1.42476934766091	AUTS2/MBD5/L3MBTL4/EZH2/AEBP2/HDAC1/PHC3	0.97496149898726
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	7/555	83/9376	1.42476934766091	CCL5/IL18/CCL4L2/IRF3/MAVS/CGAS/RIPK1	0.97496149898726
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	2/555	15/9376	2.25249249249249	AK5/NTPCR	1.21767911411383
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	6/555	69/9376	1.46901684292989	PIK3CD/SYK/VAV1/MAP2K6/MAP2K2/INPP5D	0.980802007620085
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	8/555	98/9376	1.37907703621989	ITPR2/PIK3CD/PRKCB/ITPKB/DGKD/INPP5D/PPIP5K2/INPP5F	0.946207854786052
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	13/555	173/9376	1.26946831224288	CCL5/DNAJB1/PIK3CD/IFNAR2/PRKCB/IL18/IRAK4/IRF3/PRSS3/MAP2K2/MAVS/TNFSF10/ICAM1	0.89730329293625
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	3/555	28/9376	1.81003861003861	ST3GAL3/B3GNT4/B3GALNT1	1.07670964226259
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	8/555	99/9376	1.36514696514697	ITPR2/PIK3CD/PRKCB/MAP2K6/PRKACB/CAMK2D/ADCY9/PRKCE	0.916124996737769
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	8/555	99/9376	1.36514696514697	SLC44A1/PIK3CD/PRKCB/PLD1/CHKB/MAP2K2/DGKD/SLC44A2	0.916124996737769
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	15/555	205/9376	1.23612392880686	RBL2/PIK3CD/SYK/ATF4/IRF3/RBPJ/MRPS18B/PRKACB/HDAC10/GTF2B/HDAC8/HDAC1/DDX3X/VAC14/HDAC7	0.857396691341978
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	5/555	56/9376	1.50836550836551	HSPA1B/HSPA1A/HSPA6/IL18/CLK1	0.957051598288605
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	7/555	85/9376	1.39124536301007	ENPP3/NT5C3B/AK5/NTPCR/TK2/CTPS2/AK9	0.908867669652846
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	9/555	115/9376	1.3221151586369	ITPR2/PIK3CD/PRKCB/ATF4/PRKACB/PIK3CG/CAMK2D/ADCY9/GNG11	0.871774898259331
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	6/555	72/9376	1.40780780780781	IRF3/CASP10/TANK/MAVS/DDX3X/RIPK1	0.871284829893753
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	9/555	117/9376	1.2995148995149	DPF3/SMARCA2/MORF4L2/BPTF/EPC2/ARID2/TRRAP/HDAC1/MTA2	0.817716081824066
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	3/555	30/9376	1.68936936936937	PIGN/PIGF/PIGV	0.948577764756359
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	5/555	59/9376	1.43166895709269	PIK3CD/PRKACB/ADCY9/ABHD5/PNPLA2	0.834280311954058
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	15/555	212/9376	1.19530851606323	SKAP1/PIK3CD/EVL/PRKCB/ID1/EFNA5/FYB1/BRAF/VAV1/MAP2K6/MAGI3/MAP2K2/SIPA1L3/ADCY9/CDH1	0.721472512069857
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	7/555	89/9376	1.32871748152647	ITPR2/MAP2K5/PRKCB/MAP2K2/PRKACB/ADCY9/TUBB4B	0.781543760434826
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	13/555	181/9376	1.21335921556916	SYK/VDR/IL18/IRAK4/IL10RB/LSP1/CASP10/TLR1/PPP3CA/CAMK2D/CORO1A/EEA1/PPP3CB	0.727022824196367
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	8/555	105/9376	1.28713856713857	ITPR2/PIK3CD/SYK/LSP1/PPP3CA/NFATC2/NFATC3/PPP3CB	0.74215754431993
Organismal Systems	Digestive system	hsa04976	Bile secretion	7/555	90/9376	1.31395395395395	UGT2B7/SLC10A1/PRKACB/ADCY9/ABCB1/SLC9A1/ABCC4	0.75066486780363
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	6/555	75/9376	1.3514954954955	ATM/PIK3CD/MGST1/MSH3/BRCA1/MGST2	0.766582308180945
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	6/555	75/9376	1.3514954954955	ITPR2/PRKCB/ATF4/DUOX1/PRKACB/ADCY9	0.766582308180945
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	2/555	18/9376	1.87707707707708	THAP11/ZNF143	0.934234091956199
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	8/555	106/9376	1.27499575046745	PIK3CD/E2F3/LEF1/ATF4/BRAF/MAP2K2/HSP90AA1/GSK3B	0.714187536590557
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	3/555	32/9376	1.58378378378378	IGBP1/ULK2/RPTOR	0.829724320428908
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	6/555	76/9376	1.33371266002845	ITPR2/PRKCB/PRKACB/CAMK2D/ADCY9/SLC9A1	0.732674747534425
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	9/555	122/9376	1.24625609215773	PIK3CD/NCOA1/PRKCB/MAP2K2/PRKACB/HDAC1/TBC1D4/GSK3B/SLC9A1	0.686713159456159
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	9/555	122/9376	1.24625609215773	ITPR2/PIK3CD/PRKCB/ATF4/MAP2K6/MAP2K2/PRKACB/ADCY9/GSK3B	0.686713159456159
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	10/555	138/9376	1.22418070244157	ITPR2/SPDYA/PRKACB/PPP3CA/ANAPC4/CAMK2D/ADCY9/PPP3CB/RPS6KA1/AURKA	0.6654600811008
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	4/555	47/9376	1.43776116542074	ACYP2/ACSS1/GRHPR/ACACA	0.754643495442757
NA	NA	hsa04518	Integrin signaling	11/555	154/9376	1.20669240669241	ITGAD/ITGA1/PIK3CD/SPP1/COL1A2/LIMS1/FREM2/GSK3B/ICAM1/COL9A2/CDH1	0.648702456238938
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	17/555	250/9376	1.14877117117117	HSPA1B/HSPA1A/HSPA6/ARAP2/ACAP1/PSD4/PLD1/IL2RA/TGFBR1/EEA1/WASHC3/WWP1/LDLRAP1/SMURF2/VPS25/SNX5/TFRC	0.598028350296778
Organismal Systems	Digestive system	hsa04970	Salivary secretion	7/555	93/9376	1.27156834253608	ITPR2/CD38/PRH1/PRKCB/PRKACB/ADCY9/SLC9A1	0.6601606888129
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	5/555	63/9376	1.34076934076934	LEF1/GLI1/GADD45A/GSK3B/POLK	0.680705416025516
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	9/555	125/9376	1.21634594594595	PIK3CD/PRKCB/PLD1/PPP2R3C/MAP2K2/S1PR4/CERS4/PRKCE/SGMS1	0.610776960248547
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	14/555	205/9376	1.1537156668864	MT-ATP8/MT-ND4L/PIK3CD/UQCRC2/NDUFV3/PRKCB/COL1A2/PDK4/TGFBR1/MT-ND2/CAMK2D/TBC1D4/GSK3B/GYS1	0.558161575837701
Organismal Systems	Immune system	hsa04611	Platelet activation	9/555	126/9376	1.20669240669241	ITPR2/PIK3CD/TBXAS1/SYK/ARHGEF1/COL1A2/PRKACB/PIK3CG/ADCY9	0.585884686802534
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	10/555	142/9376	1.18969673899251	PIK3CD/PECAM1/MAP2K5/SQSTM1/MEF2A/MGST1/MAP2K6/HSP90AA1/ICAM1/MGST2	0.571323806368849
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	11/555	158/9376	1.17614323183943	ATM/RBL2/E2F3/GADD45A/MTBP/ANAPC4/HDAC8/HDAC1/GSK3B/ORC3/MAU2	0.560079105107915
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	5/555	65/9376	1.2995148995149	ITPR2/PIK3CD/SPP1/PRKCB/MAP2K2	0.607785262526933
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	4/555	50/9376	1.3514954954955	AMD1/CKB/P4HA1/P4HA2	0.625072336707152
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	8/555	112/9376	1.20669240669241	HSPA1B/HSPA1A/HSPA6/IRAK4/IL10RB/MAP2K6/PIK3CG/TAB1	0.551959838633467
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	10/555	144/9376	1.17317317317317	ITPR2/PIK3CD/RORA/ERN1/PRKCB/DAB1/RBPJ/GTF2B/ULK2/MCU	0.5252755446755
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	11/555	160/9376	1.16144144144144	NCAM1/PECAM1/CLDN3/CLDN4/CD2/ALCAM/PTPRM/ICAM1/F11R/CLDN12/CDH1	0.516626885786419
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	25/555	388/9376	1.08851119160397	MT-ATP8/ITPR2/MT-ND4L/PIK3CD/UQCRC2/ERN1/NDUFV3/ATF4/SLC39A10/BRAF/FRAT2/MT-ND2/MAP2K2/PPP3CA/ADAM10/RTN3/DDIT3/ULK2/PPP3CB/MCU/SLC39A8/ATF6/GSK3B/SLC39A11/TUBB4B	0.446638069018969
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	7/555	98/9376	1.20669240669241	PIK3CD/SYK/PRKCB/PLD1/VAV1/INPP5D/PRKCE	0.515921461999457
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	7/555	98/9376	1.20669240669241	ITPR2/PRKCB/ATF4/PRKACB/CAMK2D/ADCY9/PRKCE	0.515921461999457
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	9/555	130/9376	1.16956340956341	RXFP1/PIK3CD/ATF4/COL1A2/TGFBR1/MAP2K2/PRKACB/ADCY9/GNG11	0.488315029193072
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	4/555	52/9376	1.2995148995149	ABCA1/LIPC/PLTP/LDLRAP1	0.543240561667651
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	3/555	37/9376	1.36975894813733	RIMKLB/ABAT/ASRGL1	0.565252622244371
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/555	37/9376	1.36975894813733	PRKCB/IL18/ICAM1	0.565252622244371
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	12/555	180/9376	1.12624624624625	CCL5/PIK3CD/IFNAR2/SYK/IRAK4/IRF3/PILRA/POU2F2/MAVS/TAB1/CGAS/ZC3HAV1	0.428971524032004
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/555	53/9376	1.27499575046745	VDR/PRKCB/PRKACB/ADCY9	0.50356935627922
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	7/555	101/9376	1.17085005797877	LEF1/PRKCB/MAP2K2/PRKACB/CAMK2D/ADCY9/GSK3B	0.433004168190436
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	11/555	166/9376	1.119461630305	ITPR2/ATF4/MEF2A/MAP2K2/PPP3CA/NFATC2/PIK3CG/NFATC3/ADCY9/PPP3CB/PRKCE	0.389516523098124
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	9/555	134/9376	1.13465106897943	ITPR2/ARHGEF1/PRKCB/BRAF/MAP2K2/PRKACB/MYL6B/ADCY9/PRKCE	0.393778899931619
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	4/555	54/9376	1.25138471805138	BLM/BRCA1/ERCC4/POLK	0.464680472466917
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	2/555	23/9376	1.46901684292989	PDSS2/GGPS1	0.564872078988597
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	5/555	70/9376	1.20669240669241	PIK3CD/EGLN3/BRAF/MAP2K2/FLCN	0.435376753662035
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	6/555	86/9376	1.17862979258328	PIK3CD/PRKCB/BRAF/MAP2K2/CAMK2D/GSK3B	0.417415413009219
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	13/555	200/9376	1.09809009009009	ARHGEF1/PTPN6/IL18/CLDN3/IRAK4/CLDN4/MYO1F/TAB1/MYO5A/TNFSF10/CLDN12/RIPK1/TUBB4B	0.351711563759579
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	3/555	39/9376	1.2995148995149	AHCYL2/AMT/AHCY	0.470132499482792
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	7/555	103/9376	1.14811510539666	CCL5/CD3E/PIK3CD/CCL3L1/IRAK4/TGFBR1/CFLAR	0.379123803869125
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	4/555	55/9376	1.22863226863227	GALC/B4GALT6/CERS4/SGMS1	0.426541051464936
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	13/555	201/9376	1.09262695531352	ATM/PBX3/SUPT3H/GADD45A/NSD2/SIX4/HDAC1/FLI1/DDIT3/DUSP6/CCNT1/BCL6/POLK	0.332970378517274
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	5/555	71/9376	1.18969673899251	CCL5/ATP6V1E2/CSK/ADAM10/F11R	0.402442714336179
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	17/555	268/9376	1.07161489848057	MT-ATP8/ITPR2/MT-ND4L/UQCRC2/ERN1/NDUFV3/ATF4/SLC39A10/MT-ND2/PRKACB/CAMK2D/DDIT3/MCU/SLC39A8/ATF6/SLC39A11/TUBB4B	0.298354426358605
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	11/555	170/9376	1.09312135665077	PATJ/HSPA4/CLDN3/CLDN4/PRKACB/WHAMM/MYL6B/PRKCE/STK11/F11R/CLDN12	0.307334622855184
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	16/555	253/9376	1.06837588576719	CCL5/ATM/ITPR2/PIK3CD/RPS6KA5/IL18/FNBP1L/SQSTM1/IRF3/SEPTIN9/TAB1/CGAS/GSK3B/PRKCE/RPTOR/RIPK1	0.276546143984945
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	13/555	204/9376	1.07655891185303	ITPR2/PIK3CD/ARHGEF1/PRKCB/PTPN6/COL1A2/BRAF/EIF4B/VAV1/MAP2K2/PRKACB/CAMK2D/SLC9A1	0.277301380409034
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	16/555	254/9376	1.06416968149252	ITPR2/CD38/PRKCB/ORAI2/ITPKB/PRKACB/PPP3CA/PHKB/NFATC2/CAMK2D/NFATC3/TPCN1/ADCY9/PPP3CB/MCU/ASPH	0.260060819494136
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	5/555	73/9376	1.15710230778724	MDFIC/APOBEC3H/PSIP1/APOBEC3D/CCNT1	0.337991441255076
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	10/555	155/9376	1.08991572217379	ITPR2/E2F3/LEF1/ATF4/BRAF/MAP2K2/PRKACB/CAMK2D/ADCY9/GSK3B	0.283129872606054
Human Diseases	Substance dependence	hsa05032	Morphine addiction	6/555	91/9376	1.11386991386991	GABRP/PRKCB/PRKACB/PDE7A/ADCY9/GNG11	0.27378645150826
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	3/555	42/9376	1.20669240669241	SLC39A8/TFRC/GCLC	0.336735177394925
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/555	10/9376	1.68936936936937	PAPSS1	0.547076581590558
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	5/555	75/9376	1.12624624624625	ATM/CCNG2/GADD45A/COP1/PERP	0.275332515172638
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/555	26/9376	1.2995148995149	PLB1/BTD	0.383594629946111
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	3/555	43/9376	1.17862979258328	HADH/ACAA2/ECI2	0.29447654399229
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	7/555	110/9376	1.07505323505323	PIK3CD/PRKCB/EGLN3/MAP2K2/CAMK2D/MKNK1/TFRC	0.198606212785133
Organismal Systems	Nervous system	hsa04730	Long-term depression	4/555	60/9376	1.12624624624625	ITPR2/PRKCB/BRAF/MAP2K2	0.246066548641982
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	29/555	480/9376	1.02066066066066	MT-ATP8/ITPR2/HIP1/MT-ND4L/UQCRC2/ERN1/NDUFV3/PRKCB/ATF4/SQSTM1/BRAF/FRAT2/MT-ND2/MAP2K6/C9orf72/MAP2K2/TANK/PPP3CA/DNAH7/CAMK2D/DDIT3/ULK2/PPP3CB/MCU/ATF6/GSK3B/SPG11/TUBB4B/DNAH6	0.116557615723021
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	3/555	44/9376	1.15184275184275	MGAT4A/B4GALNT3/ST3GAL3	0.253224812229158
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	8/555	128/9376	1.05585585585586	ENPP3/FHIT/AK5/PAPSS1/PDE7A/NTPCR/ADCY9/AK9	0.1595963680037
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	5/555	78/9376	1.08292908292908	PIK3CD/ARHGEF26/SEPTIN9/SEPTIN1/CDH1	0.184472915622603
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	6/555	95/9376	1.06697012802276	CCL5/ATP6V1E2/IL18/CCL3L1/ICAM1/TNFSF11	0.164557910493669
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	15/555	248/9376	1.02179598953793	PIK3CD/LEF1/IL18/IRAK4/VPS41/EXOC4/ARHGEF26/MAP2K6/MAP2K2/HSP90AA1/PIK3CG/TAB1/TNFSF10/RIPK1/TUBB4B	0.0872545000010352
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	20/555	333/9376	1.0146362578795	PATJ/ITGA1/ATM/RBL2/MAML3/PIK3CD/IFNAR2/MAML2/SPP1/ATP6V1E2/COL1A2/PPP2R3C/IRF3/RBPJ/MAP2K2/PRKACB/TADA3/HDAC1/GSK3B/COL9A2	0.0682133098445218
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	22/555	368/9376	1.0099490795143	MT-ATP8/MT-ND4L/UQCRC2/ERN1/NDUFV3/ATF4/SQSTM1/MT-ND2/MAP2K6/C9orf72/TANK/PPP3CA/DNAH7/DDIT3/ULK2/PPP3CB/MCU/NUP210L/ATF6/SPG11/TUBB4B/DNAH6	0.0488388963300826
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	6/555	97/9376	1.04497074393982	RPS6KA5/PRKCB/PRKACB/CAMK2D/ADCY9/GNG11	0.111670528250704
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	5/555	80/9376	1.05585585585586	PIK3CD/PRKCB/BRAF/MAP2K2/GSK3B	0.125845840423417
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	4/555	63/9376	1.07261547261547	POLR2A/ERCC5/MNAT1/ERCC4	0.145053382399395
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	15/555	250/9376	1.01362162162162	WDR7/CTSF/ATP6V1E2/MEAK7/VPS41/GALC/BORCS5/DEPTOR/AP4B1/TPCN1/VPS13A/CLN3/RPTOR/SPG11/FUCA1	0.0547560111452817
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/555	12/9376	1.40780780780781	COQ7	0.354559132130071
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/555	12/9376	1.40780780780781	NCAM1	0.354559132130071
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	9/555	149/9376	1.02042445129693	ITPR2/MT-ND4L/GABRP/NDUFV3/PRKCB/MT-ND2/PRKACB/ADCY9/GNG11	0.0630356870386866
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	14/555	235/9376	1.00643281579452	MT-ATP8/DPF3/SMARCA2/MT-ND4L/UQCRC2/NDUFV3/MT-ND2/PRKACB/KDM3A/SLC25A29/ADCY9/RPTOR/RPS6KA1/PNPLA2	0.0250502122980511
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	6/555	99/9376	1.02386022386022	PIK3CD/E2F3/BRAF/MAP2K2/PRKACB/ADCY9	0.0598634237513441
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	5/555	82/9376	1.03010327400571	DPYD/UGT2B7/MGST1/TK2/MGST2	0.0686740313655343
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	4/555	65/9376	1.03961191961192	LIPC/DGKD/GK/PNPLA2	0.080381780671077
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	4/555	65/9376	1.03961191961192	ITPR2/ATF4/PRKACB/ADCY9	0.080381780671077
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/555	13/9376	1.2995148995149	RAD50	0.271053996254909
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	14/555	238/9376	0.993746687864335	RPS26/RPL27A/PIK3CD/IFNAR2/SYK/RPS10/RPS15/RPL37/PRKCB/IRAK4/RPS24/IRF3/MAVS/CGAS	-0.0245101645847723
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	6/555	101/9376	1.0035857639818	PIK3CD/PRKCB/COL1A2/TGFBR1/PRKCE/ICAM1	0.00908779761995167
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	9/555	154/9376	0.987293787293787	DHRS3/UGT2B7/AK5/PPCDC/COQ7/QPRT/CTPS2/AK9/GCLC	-0.0398783463984764
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	6/555	102/9376	0.993746687864335	ITPR2/CD38/PRKCB/PRSS3/ADCY9/SLC9A1	-0.0159275825987364
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/555	14/9376	1.20669240669241	ST3GAL3	0.194123199343494
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	6/555	103/9376	0.984098661768565	PABPC1/UPF2/PPP2R3C/PCF11/DDX39B/SMG6	-0.0407019650073268
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	6/555	103/9376	0.984098661768565	COL15A1/SLC38A2/COL1A2/SLC15A1/PRSS3/COL9A2	-0.0407019650073268
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	5/555	86/9376	0.982191493819401	PRKCB/ATF4/PRKACB/CAMK2D/ADCY9	-0.0416142506518692
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	3/555	51/9376	0.993746687864335	ATP6V1E2/PRKACB/ADCY9	-0.0112316611757806
Organismal Systems	Endocrine system	hsa04924	Renin secretion	4/555	69/9376	0.979344561953258	ITPR2/PRKACB/PPP3CA/PPP3CB	-0.0431943871737367
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/555	15/9376	1.12624624624625	ST6GALNAC6	0.122737196598603
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/555	70/9376	0.965353925353925	UGT2B7/MGST1/SULT1A3/MGST2	-0.0729784695428516
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	5/555	89/9376	0.94908391537605	ITGA1/SPP1/COL1A2/FREM2/COL9A2	-0.121055771231976
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	4/555	71/9376	0.951757391194011	PIK3CD/MAP2K2/GSK3B/TNFSF11	-0.102346969893388
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/555	16/9376	1.05585585585586	B3GALNT1	0.0560872305824315
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	8/555	144/9376	0.938538538538539	PIK3CD/ID1/SKIL/ZFHX3/MAP2K2/REST/GSK3B/DLX5	-0.186427274237432
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/555	36/9376	0.938538538538539	UGT2B7/FGGY	-0.0926731476055571
NA	NA	hsa04382	Cornified envelope formation	12/555	217/9376	0.93421347614896	KRT19/KRT8/CLDN3/PPP2R3C/KRT18/CLDN4/DSP/DST/ABHD5/CLDN12/SLC27A4/PCSK6	-0.245932539928569
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	6/555	110/9376	0.921474201474201	ID1/TGFBR1/SKIL/HDAC1/SMURF2/TFRC	-0.207795326078552
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/555	17/9376	0.993746687864335	CSAD	-0.00647281303743831
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/555	17/9376	0.993746687864335	TFRC	-0.00647281303743831
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	5/555	93/9376	0.908263101811489	PIK3CD/E2F3/FHIT/GADD45A/POLK	-0.223004984057151
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	3/555	56/9376	0.905019305019305	MGAT5/DHRSX/MGAT4A	-0.178811159376453
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	4/555	76/9376	0.8891417733523	SCD5/PLTP/GK/SLC27A4	-0.243392094307401
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/555	18/9376	0.938538538538539	FUCA1	-0.0654667578704755
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	2/555	38/9376	0.8891417733523	CD3E/ZAP70	-0.171753663500881
Genetic Information Processing	Translation	hsa03010	Ribosome	12/555	222/9376	0.913172632091551	RPS26/RPL27A/RPS10/RPS15/RPL37/RACK1/RPS24/MRPL16/MRPS18B/MRPL46/MRPS31/MRPL10	-0.328398290639373
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	4/555	78/9376	0.866343266343266	PRKCB/PTPN6/IRAK4/TAB1	-0.29731484395331
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/555	19/9376	0.8891417733523	AMT	-0.121324813263796
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	3/555	59/9376	0.859001374255612	MGST1/MGST2/GCLC	-0.272505992238549
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	8/555	154/9376	0.877594477594478	RPS6KA5/ATF4/PPP2R3C/PRKACB/PIK3CG/CAMK2D/ADCY9/SLC9A1	-0.384168747717183
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	12/555	227/9376	0.893058697463984	MT-ATP8/MT-ND4L/PIK3CD/SLC26A2/UQCRC2/NDUFV3/PLD1/BRAF/MGST1/MT-ND2/MAP2K2/MGST2	-0.409114434791316
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/555	41/9376	0.82408261920457	GRHPR/AMT	-0.283150110992425
Organismal Systems	Digestive system	hsa04978	Mineral absorption	3/555	61/9376	0.830837394771821	VDR/SLC34A2/MT1F	-0.332468934510752
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	7/555	138/9376	0.8569264917091	MT-ATP8/MT-ND4L/UQCRC2/NDUFV3/ATP6V1E2/MT-ND2/PPA2	-0.424700732015292
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	8/555	157/9376	0.860825156366558	PATJ/LEF1/ID1/TGFBR1/NKD1/RASSF1/GSK3B/CDH1	-0.441104897283161
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	8/555	157/9376	0.860825156366558	PIK3CD/UQCRC2/ERN1/NDUFV3/ATF4/DDIT3/SREBF1/GSK3B	-0.441104897283161
Cellular Processes	Cell motility	hsa04814	Motor proteins	10/555	194/9376	0.87080895328318	MYO9A/STARD9/KIFAP3/DNAH7/MYO1F/MYO5A/MYO19/MYL6B/TUBB4B/DNAH6	-0.456076669331415
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/555	21/9376	0.804461604461604	DSE	-0.22500543960372
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	3/555	63/9376	0.804461604461604	PLB1/TBXAS1/PTGIS	-0.390598651226727
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/555	43/9376	0.785753195055521	ABCA1/SLC27A4	-0.353192251802154
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	4/555	83/9376	0.814153912949094	FAR2/PHYH/HMGCL/ECI2	-0.426567455043181
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	5/555	103/9376	0.820082218140471	PIK3CD/PRKCB/COL1A2/PRKACB/SERPINB6	-0.460527733883778
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	2/555	44/9376	0.767895167895168	GTF2B/MNAT1	-0.387076115349209
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	2/555	44/9376	0.767895167895168	POLG2/NEIL1	-0.387076115349209
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	2/555	44/9376	0.767895167895168	PRKACB/ADCY9	-0.387076115349209
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	5/555	104/9376	0.812196812196812	PLB1/PLD1/CHKB/DGKD/SGMS1	-0.483065627813201
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	5/555	105/9376	0.804461604461604	FKBP8/ATF4/SQSTM1/MTX2/SMURF2	-0.505401614625327
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	5/555	105/9376	0.804461604461604	ITGA1/SNTB1/TTN/PRKACB/ADCY9	-0.505401614625327
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/555	23/9376	0.734508421464943	ACY1	-0.319751373925565
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/555	23/9376	0.734508421464943	MSH3	-0.319751373925565
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	4/555	86/9376	0.785753195055521	ITGA1/LEF1/SNTB1/DSP	-0.500643914312958
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	3/555	66/9376	0.767895167895168	STAT4/RORA/IL18	-0.474629281666894
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	12/555	238/9376	0.851782875312287	PIK3CD/ZAP70/RALGAPA2/PRKCB/EFNA5/PLD1/MAP2K2/PRKACB/RASSF1/RALGAPA1/GNG11/RASA1	-0.580944312640044
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	5/555	108/9376	0.782115448782115	UPF2/RANBP17/NUP210L/DDX39B/SNUPN	-0.571239883927636
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3/555	68/9376	0.745310015898251	DHRS3/UGT2B7/RDH10	-0.52870248791719
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	2/555	47/9376	0.71888058271037	PIK3CD/PRKCE	-0.484613429554404
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	8/555	168/9376	0.804461604461604	STAT4/IFNAR2/SQSTM1/CFLAR/HSP90AA1/CAMK2D/TNFSF10/RIPK1	-0.64147133127828
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/555	48/9376	0.703903903903904	PIK3CD/PRKCB	-0.515860470770681
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	7/555	149/9376	0.793663462119838	PIK3CD/SYK/PLD1/MAP2K2/DGKD/PIK3CG/ADCY9	-0.636813456448259
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	11/555	226/9376	0.822259427569162	PIK3CD/GLI1/PLD1/BRAF/VAV1/MAP2K2/PRKACB/CAMK2D/ADCY9/SLC9A1/ABCC4	-0.67842753450806
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	3/555	70/9376	0.724015444015444	SNTB1/CD55/ICAM1	-0.581333692747738
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	2/555	49/9376	0.689538518109947	ATF4/PRKACB	-0.546522437309371
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/555	26/9376	0.64975744975745	PLB1	-0.448562531177151
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	16/555	323/9376	0.836839316096282	ATM/PIK3CD/E2F3/RPS6KA5/PRKCB/SPRY2/SIRT1/EFNA5/EZH2/MAP2K2/RASSF1/HDAC1/ABCB1/BRCA1/PRKCE/RPTOR	-0.748503329882935
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/555	51/9376	0.662497791909557	PLB1/PLD1	-0.606192424927863
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3/555	73/9376	0.694261384672344	UGT2B7/MGST1/MGST2	-0.657769046791301
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	11/555	232/9376	0.800994097545822	ITGAD/ITGA1/PIK3CD/ARHGEF1/SSH2/BRAF/VAV1/MAP2K2/FGD3/SPATA13/SLC9A1	-0.769865858258391
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	5/555	115/9376	0.734508421464943	ITPR2/PRKCB/BRAF/PRKACB/GNG11	-0.718528413395805
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	15/555	308/9376	0.822744822744823	MT-ATP8/HIP1/MT-ND4L/UQCRC2/ERN1/NDUFV3/POLR2A/MT-ND2/RCOR1/DNAH7/REST/HDAC1/ULK2/TUBB4B/DNAH6	-0.793399185190976
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/555	28/9376	0.603346203346203	MOCOS	-0.52723532212477
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/555	28/9376	0.603346203346203	ATP6V1E2	-0.52723532212477
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	2/555	52/9376	0.64975744975745	PRKACB/ADCY9	-0.635247061237461
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	9/555	195/9376	0.77970893970894	PIK3CD/SYK/PRKCB/MAP2K2/HDAC10/HDAC8/HDAC1/HDAC7/PADI4	-0.7797266964789
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	5/555	116/9376	0.728176452314383	PCCA/ACSS1/HIBCH/ALDH6A1/AMT	-0.738896818039332
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/555	29/9376	0.582541161851507	RASSF1	-0.564741569410743
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/555	30/9376	0.563123123123123	PLB1	-0.601146076044412
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/555	30/9376	0.563123123123123	ABCC4	-0.601146076044412
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	4/555	99/9376	0.682573482573483	DEFB1/KRT19/KRT18/ICAM1	-0.796398149235081
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	3/555	78/9376	0.64975744975745	ZCCHC7/PABPC1/EXOSC9	-0.779102603529223
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/555	31/9376	0.544957861086893	RBKS	-0.63652582563425
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/555	31/9376	0.544957861086893	UGT2B7	-0.63652582563425
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/555	31/9376	0.544957861086893	IMMP2L	-0.63652582563425
NA	NA	hsa04981	Folate transport and metabolism	1/555	31/9376	0.544957861086893	ABCC4	-0.63652582563425
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	14/555	298/9376	0.793663462119838	CCL5/IL32/IFNAR2/IL16/IL18/CCL4L2/CCL3L1/IL2RA/CXCL14/TGFBR1/IL10RB/TNFSF10/CCL18/TNFSF11	-0.907950978061825
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3/555	79/9376	0.641532671912419	UGT2B7/MGST1/MGST2	-0.802536747725265
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	9/555	203/9376	0.74898149380908	ITGA1/PIK3CD/SPP1/PRKCB/COL1A2/BRAF/VAV1/GSK3B/COL9A2	-0.906924807893985
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/555	33/9376	0.511930111930112	ACY1	-0.704480584612642
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/555	33/9376	0.511930111930112	VTI1A	-0.704480584612642
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/555	34/9376	0.496873343932167	POLR2A	-0.737174108055792
Human Diseases	Substance dependence	hsa05034	Alcoholism	8/555	191/9376	0.707589264657328	ATF4/BRAF/PRKACB/HDAC10/HDAC8/HDAC1/HDAC7/GNG11	-1.02410299197431
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/555	36/9376	0.469269269269269	RNASEH2B	-0.800249232255152
Organismal Systems	Sensory system	hsa04742	Taste transduction	3/555	86/9376	0.58931489629164	PRKACB/TAS2R30/SCNN1A	-0.959673577974046
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	3/555	87/9376	0.582541161851507	UQCRC2/SLC9A1/ASPH	-0.981210131022481
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/555	37/9376	0.456586316045776	HGD	-0.830719611698266
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/555	37/9376	0.456586316045776	GALK2	-0.830719611698266
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/555	38/9376	0.44457088667615	GALK2	-0.86053140044881
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2/555	66/9376	0.511930111930112	UGT2B7/HSD17B8	-0.998050140865764
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	2/555	67/9376	0.504289363990856	GAPDHS/ACSS1	-1.02137998272515
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/555	41/9376	0.412041309602285	GABRP	-0.946356566317177
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	3/555	94/9376	0.539160437032777	HSP90AA1/USP25/GSK3B	-1.12633121321703
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/555	42/9376	0.402230802230802	HADH	-0.973862175554355
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	2/555	71/9376	0.475878695597005	PIK3CD/MAP2K2	-1.11192633835252
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	3/555	99/9376	0.511930111930112	ITGA1/SNTB1/TTN	-1.22452893572829
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	6/555	168/9376	0.603346203346203	STAT4/PIK3CD/IFNAR2/PTPN6/IL2RA/IL10RB	-1.30123824681856
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/555	46/9376	0.367254210732472	UGT2B7	-1.07904753367043
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	2/555	78/9376	0.433171633171633	IRAK4/IRF3	-1.26089036310514
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	1/555	49/9376	0.344769259054973	ST3GAL3	-1.15343874338691
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	5/555	155/9376	0.544957861086893	ATP6V1E2/CORO1A/EEA1/TUBB4B/TFRC	-1.43285311740969
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	8/555	233/9376	0.5800409851912	ITGA1/SNTB1/TTN/COL1A2/MYOM1/DSP/SYNE2/COL9A2	-1.62822240899124
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	2/555	88/9376	0.383947583947584	CD55/SERPINE2	-1.4563679622027
NA	NA	hsa04519	Cadherin signaling	16/555	404/9376	0.669057175987869	EVL/KRT19/LEF1/KRT8/GABRP/TAOK3/KRT18/TMC8/VAV1/DSP/MAP2K2/ADAM10/MYO1F/GSK3B/RERE/CDH1	-1.70558055999745
NA	NA	hsa04082	Neuroactive ligand signaling	6/555	199/9376	0.509357598804835	GRIK4/GABRP/PRKCB/PRKACB/ADCY9/GNG11	-1.75474683674525
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	1/555	70/9376	0.241338481338481	STK11	-1.59804413915751
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/555	75/9376	0.225249249249249	ACY1	-1.68966665686059
Genetic Information Processing	Transcription	hsa03040	Spliceosome	7/555	243/9376	0.486649612575539	HSPA1B/HSPA1A/HSPA6/PRPF6/RBM22/TRA2B/DDX39B	-2.03368422938004
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	1/555	79/9376	0.213844223970806	ATP6V1E2	-1.76004575665471
NA	NA	hsa04081	Hormone signaling	5/555	219/9376	0.385700769262413	PIK3CD/PRKACB/ADCY9/STK11/GNG11	-2.30727117553563
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	2/555	183/9376	0.184630532171516	NVL/REXO1	-2.79398826972198
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	8/555	370/9376	0.36526905283662	GAL/RXFP1/GRIK4/GABRP/CNR2/PRSS3/PTGDR/S1PR4	-3.12462413426442
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	4/555	449/9376	0.150500611970545	OR2Z1/PRKACB/CAMK2D/NCALD	-4.62707663189906