category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	54/551	238/9376	3.86084887675578	RPL27A/FOS/RPS10/RPL13A/RPS3/RPL37/RPS15/RPLP2/RPL41/RPL38/RPS24/RPS13/RPS25/RPS26/RPS11/RPS23/RPL18/RPL34/RPS19/RPS27/RPS14/RPL39/RPL31/RPL8/RPL37A/SYK/RPS28/RPL3/RPL32/RPL36/RPL30/FAU/RPL9/IFNAR2/JUN/IRF3/RPL17/IRAK4/RPS16/RPL19/CGAS/UBA52/RPS18/RPS2/RPL5/RPL23/RPL14/RPS20/RPL35A/TNFRSF1A/RPL26/RPL36A/PIK3CD/RPSA	11.1702244369863
Genetic Information Processing	Translation	hsa03010	Ribosome	50/551	222/9376	3.83250764375991	RPL27A/RPS10/RPL13A/RPS3/RPL37/RPS15/RACK1/RPLP2/RPL41/RPL38/RPS24/RPS13/RPS25/RPS26/RPS11/RPS23/RPL18/RPL34/MRPL18/RPS19/RPS27/RPS14/RPL39/RPL31/RPL8/RPL37A/RPS28/RPL3/RPL32/RPL36/RPL30/FAU/RPL9/RPL17/RPS16/RPL19/UBA52/RPS18/RPS2/RPL5/RPL23/RPL14/RPS20/RPL35A/MRPL34/MRPL16/MRPS31/RPL26/RPL36A/RPSA	10.6720095275261
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	18/551	82/9376	3.73529281572308	HSPA1B/HSPA1A/HSP90AA1/HSPA6/KIR2DL3/KLRD1/KIR2DL4/KIR2DL1/HSPA2/HSP90AB1/HSPA4/HLA-E/NFYB/KIR3DL1/CD8A/KIR3DL2/HSPA1L/HSPA8	6.21603566380623
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	30/551	216/9376	2.36337971365195	HSPA1B/HSPA1A/FOS/CCL3L1/HSP90AA1/HSPA6/CCL5/ATF4/ABCA1/DDIT3/CCL3/HSPA2/HSP90AB1/IL18/MAP2K6/HSPA4/CAMK2D/XBP1/JUN/IRF3/CD36/IRAK4/PLCB4/ARHGEF1/NFATC3/HSPA1L/TNFRSF1A/ICAM1/PIK3CD/HSPA8	5.06524022347128
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	20/551	133/9376	2.55884720876602	TYROBP/KIR2DL3/KLRD1/KIR2DL4/KIR2DL1/PTPN6/SYK/HLA-E/LCP2/PRF1/IFNAR2/FCER1G/GZMB/KIR3DL1/NCR1/CD48/KIR3DL2/ICAM1/PIK3CD/ZAP70	4.52404560517803
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	15/551	93/9376	2.74456999004742	LEF1/PTPN6/TGFBR1/CCM2/PTPRM/MET/TJP1/SNAI1/CTNNA2/WAS/CDH1/VCL/CTNND1/AFDN/RADIL	4.2246406849784
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	22/551	174/9376	2.15149049794522	HSPA1B/HSPA1A/DNAJB1/DNAJA1/HSP90AA1/HSPA6/HSPH1/ERP29/ATF4/DDIT3/HSP90AB1/PPP1R15A/HERPUD1/XBP1/UBXN1/UBE2D2/PRKN/SSR2/HSPA1L/RRBP1/HSPA8/ERO1B	3.83087471293898
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	17/551	133/9376	2.17502012745111	SGK1/GADD45B/GADD45A/CDKN2D/ATM/HOMER2/RBL2/TGFBR1/KLF2/DEPP1/SIRT1/FBXO32/CCNG2/PLK2/S1PR4/BCL6/PIK3CD	3.41011268692521
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	14/551	100/9376	2.38228675136116	CCL3L1/CCL5/CXCL14/CCL4L2/CCL3/IL18/CCL18/IL20RA/CX3CR1/CCL4/CCR1/TNFSF14/TNFRSF1A/IL10RB	3.47233690470157
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	17/551	138/9376	2.09621505036955	FOS/ARPC5L/IL18/MAP2K6/LCP2/JUN/IRF3/IRAK4/FYB1/PXN/ARHGEF12/ARHGEF1/WAS/NFATC3/CD8A/PIK3CD/ZAP70	3.24153268636381
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	22/551	200/9376	1.87179673321234	FOS/MYO1E/RPS3/ARPC5L/TUBA1B/CLDN4/TUBB4B/IL18/PTPN6/CLDN3/MYO1F/JUN/IRAK4/TJP1/ARHGEF12/ARHGEF1/MYO10/TUBA1C/TNFRSF1A/MYO5C/CLDN12/TUBB	3.11392116445842
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	8/551	45/9376	3.02512603347449	KIR2DL3/KLRD1/KIR2DL1/HLA-E/PRF1/GZMB/KIR3DL1/KIR3DL2	3.40250129701374
NA	NA	hsa04517	IgSF CAM signaling	29/551	299/9376	1.65041365956698	NCAM1/ITGAX/ARPC5L/TUBA1B/MBP/CD2/TUBB4B/DYNLL1/PTPN6/GRIP1/SLIT2/LCP2/DOK2/TRIO/CD226/TJP1/PXN/SRGAP3/CDH1/VCL/CD48/MAGI1/TUBA1C/CADM1/ICAM1/PIK3CD/TUBB/AFDN/ANK3	2.85599971975467
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	29/551	300/9376	1.64491228070175	HSPA1B/HSPA1A/FOS/HSPA6/MECOM/ATF4/GADD45B/GADD45A/DDIT3/RPS6KA5/MAP2K6/TGFBR1/DUSP1/JUN/MET/IRAK4/PRKACB/NR4A1/ERBB4/NFATC3/DUSP6/TAOK3/CACNA2D4/HSPA1L/TNFRSF1A/MAP3K4/HSPA8/EFNA5/RRAS	2.83673071707933
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	16/551	137/9376	1.98730907308543	FOS/ATF4/TUBA1B/GADD45B/GADD45A/DDIT3/ATM/BBC3/PRF1/JUN/GZMB/CTSF/TUBA1C/TNFRSF1A/CASP10/PIK3CD	2.90874070634981
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	14/551	115/9376	2.07155369683579	FOS/SGK1/ATF4/MEF2A/SLC34A2/PLCB4/PRKACB/EGR1/PLD1/ARHGEF1/NACA/TNFSF11/NR4A2/VDR	2.88893651084648
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	16/551	139/9376	1.95871469793312	HSPA1B/HSPA1A/FOS/HSP90AA1/HSPA6/KRT19/ATF4/KRT18/HSP90AB1/JUN/PLCB4/PRKACB/KRT23/HSPA1L/PIK3CD/HSPA8	2.8453480270251
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	8/551	50/9376	2.72261343012704	SAT1/CKB/ARG2/P4HA1/P4HA2/CNDP2/AMD1/MAOA	3.05161124108262
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	13/551	105/9376	2.10678420188402	GADD45B/CCL4L2/GADD45A/ATM/SYK/IRAK4/CCL4/TNFSF14/TNFSF11/CARD11/TNFRSF1A/ICAM1/ZAP70	2.84969506982565
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	16/551	142/9376	1.91733340149792	TYROBP/FOS/TEC1/SQSTM1/SOCS1/MAP2K6/TGFBR1/SYK/JUNB/LCP2/IFNAR2/JUN/TNFSF11/FOSB/TNFRSF1A/PIK3CD	2.75220338582303
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	16/551	142/9376	1.91733340149792	FOS/HSP90AA1/MGST1/SQSTM1/HSP90AB1/MEF2A/MAP2K6/KLF2/DUSP1/MGST2/JUN/SDC2/TNFRSF1A/BMPR1B/ICAM1/PIK3CD	2.75220338582303
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	13/551	109/9376	2.02947102016351	FOS/CCL3L1/SPP1/CCL5/CCL4L2/CCL3/MAP2K6/IFNAR2/JUN/IRF3/IRAK4/CCL4/PIK3CD	2.70123192393954
Human Diseases	Infectious disease: viral	hsa05162	Measles	15/551	136/9376	1.87680153731184	HSPA1B/HSPA1A/FOS/HSPA6/RACK1/CD3E/BBC3/IFNAR2/JUN/IRF3/IRAK4/HSPA1L/CCND3/PIK3CD/HSPA8	2.57358698593879
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	22/551	227/9376	1.6491601173677	CCL3L1/CCL5/ATF4/CCL4L2/CCL3/MAP2K6/HLA-E/IRF3/PLCB4/PRKACB/CGAS/CCL4/PXN/PTGER2/ARHGEF12/ARHGEF1/CCR1/NFATC3/GNG11/TNFRSF1A/PIK3CD/IL10RB	2.47389934436541
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	18/551	178/9376	1.72075287016456	CACYBP/LEF1/CCDC88C/LGR4/CAMK2D/SIRT1/SOX17/JUN/PLCB4/PRKACB/CELSR1/NFATC3/FRAT2/CCND3/INVS/CTBP2/CBY1/BAMBI	2.42579311805999
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	16/551	157/9376	1.73414868160958	GADD45B/GADD45A/KIR2DL4/SQSTM1/ATM/RBL2/MAP2K6/TGFBR1/HLA-E/SIRT1/NFATC3/CCND3/RAD50/PIK3CD/LIN37/RRAS	2.31790708268186
Organismal Systems	Digestive system	hsa04978	Mineral absorption	8/551	61/9376	2.23165035256315	FTL/MT1G/SLC34A2/MT1E/MT1F/MT1M/VDR/TRPM6	2.4113763878223
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	16/551	160/9376	1.7016333938294	NCAM1/CD2/ALCAM/CLDN4/ITGB8/CLDN3/HLA-E/PTPRM/NRXN3/CD226/SDC2/CDH1/CADM1/CD8A/ICAM1/CLDN12	2.2366760619164
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	7/551	50/9376	2.38228675136116	IL18/KLRB1/MET/CD36/HBA1/SDC2/ICAM1	2.44872222350096
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	8/551	62/9376	2.19565599203794	HSPA1B/HSPA1A/HSPA6/SIRT1/PRKACB/HSPA1L/PIK3CD/HSPA8	2.36014156386129
Organismal Systems	Immune system	hsa04611	Platelet activation	13/551	126/9376	1.75565350157002	COL1A2/TBXAS1/SYK/LCP2/PLCB4/PRKACB/FCER1G/PIK3R6/ARHGEF12/ARHGEF1/ITGA2/PIK3CD/SNAP23	2.13373846298563
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	22/551	248/9376	1.50951349452608	FOS/HSP90AA1/RPS3/ARPC5L/TUBA1B/TUBB4B/DYNLL1/HSP90AB1/LEF1/IL18/MAP2K6/ANXA2/AHNAK/JUN/IRAK4/RHOB/TUBA1C/TNFRSF1A/VPS41/PIK3CD/TUBB/RRAS	2.03187878636596
NA	NA	hsa04518	Integrin signaling	15/551	154/9376	1.65743512385981	ITGAD/COL1A2/SPP1/ITGAX/ITGB8/FREM2/MET/PXN/CDH1/VCL/ITGA2/CCND3/COL9A2/ICAM1/PIK3CD	2.0554399100389
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	11/551	103/9376	1.81727838175955	FOS/CCL3L1/CCL5/CD3E/CCL3/TGFBR1/JUN/IRAK4/PLCB4/TNFRSF1A/PIK3CD	2.08392734949764
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	11/551	105/9376	1.78266355544032	ATF4/CITED2/SQSTM1/JUN/UBA52/FKBP8/MTX2/PRKN/PHB2/TOMM7/RRAS	2.01516471907884
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	7/551	56/9376	2.12704174228675	HSPA1B/HSPA1A/HSPA6/IL18/EEF1G/HSPA1L/HSPA8	2.11363571721954
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	8/551	69/9376	1.97290828270075	FOS/ATF4/CAMK2D/SIRT1/JUN/PRKACB/FOSB/MAOA	2.02672894378287
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	10/551	95/9376	1.79119304613621	FOS/CCL3L1/CCL5/CCL3/IL18/JUN/TNFSF11/IL23A/ICAM1/ATP6V1C2	1.93664918964732
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	23/551	275/9376	1.42318429302095	HSPA1B/MT-ATP8/HSPA1A/NCAM1/MT-ND4L/HSPA6/CCL5/ATF4/MT-ND2/TUBA1B/TUBB4B/DDIT3/COX6A2/NDUFV3/PRKACB/EGR1/ATP5MC2/NDUFV1/TUBA1C/HSPA1L/PIK3CD/TUBB/HSPA8	1.77973528281182
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	17/551	193/9376	1.49884806710362	CCL3L1/CCL5/CXCL14/CCL4L2/CCL3/CCL18/FGR/PLCB4/PRKACB/CX3CR1/CCL4/PIK3R6/PXN/WAS/CCR1/GNG11/PIK3CD	1.74968043975382
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	11/551	112/9376	1.6712470832253	HSPA1B/HSPA1A/HSPA6/SOCS1/MAP2K6/IRAK4/PIK3R6/HSPA1L/TNFRSF1A/IL10RB/HSPA8	1.78564955675629
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	19/551	224/9376	1.44334975369458	FOS/ATF4/CD3E/ATM/TGFBR1/HLA-E/CDKN2C/MSX1/JUN/PRKACB/EGR1/NFYB/NFATC3/CDC16/TNFRSF1A/CCND3/ICAM1/PIK3CD/ANAPC4	1.67809504705529
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	17/551	196/9376	1.47590651505611	FOS/LEF1/MAP2K6/SYK/HLA-E/IFNAR2/JUN/IRF3/UBA52/PIK3R6/CCR1/NFATC3/GNG11/TNFRSF1A/ICAM1/CD200R1/PIK3CD	1.68241226560982
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	14/551	157/9376	1.51738009640838	SGK1/ABCA1/CD24/PTPN6/ARG2/CAMK2D/SIRT1/CD36/CX3CR1/PTGER2/HAVCR1/NFATC3/GULP1/VPS41	1.6335096962571
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	14/551	157/9376	1.51738009640838	ID1/LEF1/RASSF1/TGFBR1/PATJ/BBC3/RASSF6/WWC1/CTNNA2/CDH1/YAP1/CCND3/BMPR1B/YWHAH	1.6335096962571
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	11/551	116/9376	1.61361787345891	TXK/CLDN4/CLDN3/PXN/CTNNA2/VCL/CTNND1/ICAM1/CLDN12/PIK3CD/AFDN	1.66159655507372
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	9/551	90/9376	1.7016333938294	FOS/CD3E/PTPN6/MAP2K6/JUN/NFATC3/PIK3CD/ALK/ZAP70	1.67117236916131
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	8/551	78/9376	1.74526501931221	ARPC5L/MET/PXN/CTNNA2/CDH1/VCL/PIK3CD/SEPTIN1	1.65145729643923
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	4/551	29/9376	2.34708054321297	RASSF1/RASSF6/WWC1/YAP1	1.81535063548494
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	11/551	119/9376	1.57293843127087	FOS/CCL5/ATF4/RPS6KA5/MAP2K6/JUNB/JUN/TNFRSF1A/CASP10/ICAM1/PIK3CD	1.57163026708429
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	5/551	41/9376	2.07516267540171	DAPK2/RPS6KA5/RASSF1/DAPK1/CDH1	1.72390380055989
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	9/551	93/9376	1.64674199402845	ATF4/MAP2K6/CAMK2D/JUN/PLCB4/PRKACB/EGR1/PLD1/MAP3K4	1.56614670448526
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	11/551	122/9376	1.53425961738716	FOS/CD3E/TEC1/PTPN6/LCP2/JUN/NFATC3/CD8A/CARD11/PIK3CD/ZAP70	1.4841288148592
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	4/551	31/9376	2.19565599203794	CNDP2/HIBCH/DPYD/ALDH6A1	1.66610174527227
Cellular Processes	Cell motility	hsa04814	Motor proteins	16/551	194/9376	1.40340898460157	MYO1E/TUBA1B/TUBB4B/DYNLL1/MYO1F/DNAH14/STARD9/DNAH11/MYO10/TUBA1C/DNAH7/KIFAP3/MYO5C/TUBB/KIF2A/MYO9A	1.41867157715024
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	21/551	268/9376	1.33336945038871	MT-ATP8/MT-ND4L/ATF4/MT-ND2/TUBA1B/TUBB4B/DDIT3/COX6A2/SLC39A14/CAMK2D/XBP1/DUSP1/NDUFV3/PRKACB/UBA52/ATP5MC2/NDUFV1/TUBA1C/PRKN/MAOA/TUBB	1.38352103232366
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	15/551	181/9376	1.41019342030061	ITGAX/IL18/SYK/CAMK2D/IRAK4/FCER1G/NFYB/ARHGEF12/CORO1A/LSP1/IL23A/TNFRSF1A/CASP10/VDR/IL10RB	1.39237491691726
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	12/551	140/9376	1.45854290899663	SPP1/MEF2A/TGFBR1/KLF2/PLCB4/PRKACB/EGR1/PIK3R6/CDH1/GNG11/TFAM/RRAS	1.36585978449282
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	14/551	169/9376	1.40963713098294	DAPK2/SQSTM1/DDIT4/C9orf72/DEPTOR/WDFY3/PRKACB/UBA52/DAPK1/MLST8/VPS41/IGBP1/PIK3CD/RRAS	1.34272686133725
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	3/551	21/9376	2.43090484832772	ENPP3/DPYD/PPCDC	1.64022182827741
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	14/551	170/9376	1.40134514785951	ARPC5L/TUBA1B/CLDN4/PATJ/CLDN3/HSPA4/JUN/PRKACB/TJP1/WAS/MAGI1/TUBA1C/CLDN12/AFDN	1.31950509914328
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	6/551	59/9376	1.73047463779261	ENPP3/NT5C3B/ENTPD3/TK2/DPYD/AK9	1.40636218523932
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	6/551	59/9376	1.73047463779261	GADD45B/GADD45A/LEF1/CTNNA2/CDH1/PIK3CD	1.40636218523932
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	8/551	86/9376	1.58291478495758	DSP/ITGB8/LEF1/SGCD/CTNNA2/CACNA2D4/ITGA2/SNTB1	1.35690836582924
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	8/551	87/9376	1.56472036214198	FOS/GADD45B/GADD45A/LEF1/TGFBR1/BBC3/JUN/PIK3CD	1.32224725123885
NA	NA	hsa03272	Virion - Hepatitis viruses	5/551	48/9376	1.77253478523896	SLC10A1/CLDN4/CLDN3/EPCAM/CLDN12	1.34075206419943
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	3/551	23/9376	2.21952181803835	PDSS2/GGPS1/PCYOX1	1.46312727379082
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	7/551	75/9376	1.58819116757411	GADD45B/GADD45A/ATM/BBC3/PERP/CCNG2/CCND3	1.27787504427445
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/551	12/9376	2.83605565638233	COQ7/COQ5	1.59019302042229
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	5/551	49/9376	1.73636060594837	ATF4/JUN/PRKACB/FOSB/MAOA	1.29128372895964
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	9/551	105/9376	1.45854290899663	SYK/JUN/FCER1G/ARHGEF12/LSP1/NFATC3/IL23A/PIK3CD/RRAS	1.18063436833203
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	8/551	91/9376	1.49594144512475	FOS/PTPN6/SYK/JUN/NFATC3/CARD11/CD72/PIK3CD	1.18785717666395
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	4/551	37/9376	1.83960366900476	IL18/PLCB4/HBA1/ICAM1	1.27858346194057
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	4/551	37/9376	1.83960366900476	GADD45B/GADD45A/LEF1/CDH1	1.27858346194057
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	16/551	212/9376	1.28425161798445	ID1/EVL/MAP2K6/LCP2/MET/PLCB4/FYB1/CDH1/MAGI1/MAGI3/CTNND1/PIK3CD/RGS14/AFDN/EFNA5/RRAS	1.04600176225165
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	26/551	368/9376	1.20224098477077	MT-ATP8/MT-ND4L/ATF4/MT-ND2/TUBA1B/TUBB4B/DDIT3/SQSTM1/COX6A2/MAP2K6/SRSF3/C9orf72/FUS/XBP1/NDUFV3/DNAH14/ATP5MC2/DNAH11/ERBB4/NDUFV1/TUBA1C/DNAH7/PRKN/TNFRSF1A/TUBB/GPX3	0.988969669448329
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	5/551	52/9376	1.63618595560519	ABCA1/LIPC/MYLIP/CD36/OSBPL5	1.14944632849584
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	9/551	109/9376	1.40501839857474	FOS/HSP90AA1/CD3E/HSP90AB1/TGFBR1/JUN/NFATC3/IL23A/ZAP70	1.06272892250933
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/551	14/9376	2.43090484832772	FUT8/ST3GAL3	1.33873474559841
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	15/551	201/9376	1.26987566703687	GADD45B/GADD45A/DDIT3/ATM/FUS/CDKN2C/FUT8/MET/GZMB/FLI1/PBX3/BCL6/DUSP6/SPINT1/SIX4	0.966413085111466
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	16/551	217/9376	1.25466056687882	FOS/HSP90AA1/ATF4/UGT2B7/MGST1/HSP90AB1/MGST2/JUN/KLF5/PRKACB/BCL6/TNFSF11/CCND3/PTGES3/VDR/PIK3CD	0.948356487588246
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	7/551	83/9376	1.43511250081998	CCL5/CCL4L2/IL18/IRF3/CGAS/CCL4/DNASE2	0.994870879549589
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	8/551	98/9376	1.38908848475869	ARPC5L/SYK/SCIN/PLD1/WAS/MYO10/PIK3CD/PLPP1	0.967471793788664
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	12/551	158/9376	1.29237979278182	GADD45B/GADD45A/CDKN2D/ATM/RBL2/CDKN2C/CDKN1C/ORC4/CDC16/CCND3/YWHAH/ANAPC4	0.926107979447461
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	4/551	41/9376	1.66013014032137	ALAS1/GRHPR/MAOA/SDSL	1.0584452788402
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	4/551	41/9376	1.66013014032137	ATM/ABRAXAS1/RPA2/RAD50	1.0584452788402
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/551	15/9376	2.26884452510587	B4GALNT1/SLC33A1	1.22884469119749
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	2/551	15/9376	2.26884452510587	AK5/AK4	1.22884469119749
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	21/551	298/9376	1.19913762652407	CCL3L1/CCL5/CXCL14/CCL4L2/CCL3/IL16/IL18/TGFBR1/CCL18/IFNAR2/IL20RA/CX3CR1/CCL4/CCR1/TNFSF14/TNFSF11/IL23A/TNFRSF1A/BMPR1B/IL32/IL10RB	0.872911972217561
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	15/551	205/9376	1.24509760524103	ATF4/RBL2/SYK/HLA-E/JUN/IRF3/PRKACB/SCIN/PXN/DDX3X/CCND3/PIK3CD/YWHAH/GTF2H1/GTF2B	0.886567348029091
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	15/551	205/9376	1.24509760524103	MT-ATP8/COL1A2/MT-ND4L/MT-ND2/PDK4/COX6A2/TGFBR1/CAMK2D/NDUFV3/CD36/PLCB4/ATP5MC2/CPT2/NDUFV1/PIK3CD	0.886567348029091
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	3/551	28/9376	1.82317863624579	THEM4/ACAA2/MBLAC2	1.08997825823836
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	3/551	28/9376	1.82317863624579	ST3GAL6/B3GNT4/ST3GAL3	1.08997825823836
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	8/551	99/9376	1.37505728794295	FOS/SLC44A1/JUN/CHKB/PLD1/WAS/PIK3CD/PLPP1	0.93737962301796
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	25/551	362/9376	1.17516118358384	COL1A2/HSP90AA1/SPP1/SGK1/ATF4/ITGB8/HSP90AB1/RBL2/DDIT4/SYK/IFNAR2/MET/THEM4/NR4A1/PIK3R6/ERBB4/MAGI1/ITGA2/GNG11/CCND3/COL9A2/MLST8/PIK3CD/YWHAH/EFNA5	0.849253724318064
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	4/551	42/9376	1.62060323221848	FTL/SAT1/CP/SLC39A14	1.00718409892309
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	7/551	85/9376	1.40134514785951	ENPP3/NT5C3B/ENTPD3/TK2/AK5/AK4/AK9	0.928753215285172
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	18/551	253/9376	1.21064826438455	CCL5/ARPC5L/SQSTM1/RPS6KA5/IL18/ATM/TIFA/JUN/IRF3/PLCB4/CGAS/UBA52/UBE2D2/PXN/VCL/FNBP1L/TNFRSF1A/PIK3CD	0.848698410699328
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	8/551	100/9376	1.36130671506352	CD37/CD24/CD2/CD3E/CD36/CD59/CD8A/ITGA2	0.907610985489193
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	10/551	130/9376	1.30894876448415	RXFP1/FOS/COL1A2/ATF4/TGFBR1/JUN/PLCB4/PRKACB/GNG11/PIK3CD	0.886309235935009
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	9/551	115/9376	1.33171309082301	FOS/ATF4/CAMK2D/PLCB4/PRKACB/PIK3R6/CHRM3/GNG11/PIK3CD	0.894307081422144
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	6/551	71/9376	1.43800005112344	FOS/SOCS1/CISH/TNFSF11/SOCS2/PIK3CD	0.925655162122782
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	4/551	43/9376	1.58291478495758	ABCA1/CD36/PLPP1/SLC27A4	0.957266247556596
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	12/551	163/9376	1.252736240856	FOS/SLC10A1/ATF4/MAP2K6/TGFBR1/JUN/IRF3/IRAK4/DDX3X/NFATC3/CASP10/PIK3CD	0.813326398869031
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	6/551	73/9376	1.39860278944882	GADD45B/GADD45A/RASSF1/MET/PIK3CD/ALK	0.85426838422094
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	4/551	44/9376	1.54693944893582	MGAT4A/FUT8/B4GALNT3/ST3GAL3	0.908620021956653
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	8/551	103/9376	1.32165700491604	COL1A2/SLC38A2/SLC15A1/PRSS3/COL28A1/COL9A2/COL15A1/COL25A1	0.82017320494749
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	16/551	227/9376	1.19938917626742	MT-ATP8/FOS/SLC26A2/MT-ND4L/MT-ND2/MGST1/COX6A2/MGST2/NDUFV3/JUN/MET/ATP5MC2/CBR1/PLD1/NDUFV1/PIK3CD	0.759856835385542
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/551	17/9376	2.0019216397993	PAPSS1/SEPHS2	1.03311240035586
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	7/551	89/9376	1.33836334346133	COL1A2/SPP1/ITGB8/FREM2/CD36/ITGA2/COL9A2	0.801391383899126
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	7/551	89/9376	1.33836334346133	TUBA1B/TUBB4B/PLCB4/PRKACB/TJP1/TUBA1C/TUBB	0.801391383899126
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	3/551	31/9376	1.64674199402845	GRHPR/HYI/MCEE	0.901210692847413
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	15/551	214/9376	1.1927336872636	FOS/CD3E/ATM/MAP2K6/HLA-E/APOBEC3H/JUN/IRF3/IRAK4/CGAS/PXN/NFATC3/GNG11/TNFRSF1A/PIK3CD	0.712645346672151
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	4/551	46/9376	1.47968121202557	FTL/UGT2B7/CP/ALAS1	0.814882297094031
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	2/551	18/9376	1.89070377092156	FUCA1/ENGASE	0.94510944577216
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	2/551	18/9376	1.89070377092156	THAP11/ZNF143	0.94510944577216
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	9/551	122/9376	1.25530332331677	FOS/ATF4/SOCS1/MAP2K6/JUNB/PLCB4/PRKACB/SOCS2/PIK3CD	0.709211413950371
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	3/551	32/9376	1.59528130671506	HIBCH/MCEE/ALDH6A1	0.842820129881409
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	6/551	77/9376	1.32594809908784	MECOM/GADD45B/GADD45A/TGFBR1/CTBP2/PIK3CD	0.717595607927118
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	7/551	93/9376	1.2807993286888	FOS/MAML3/CD3E/MAML2/JUN/NFATC3/ZAP70	0.679982044320885
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	6/551	78/9376	1.30894876448415	PIP4K2A/PLCB4/TPI1/PIK3CD/ALDH6A1/INPP5F	0.684609740309715
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	4/551	48/9376	1.41802782819117	ACAA2/HIBCH/MCEE/ALDH6A1	0.725497005764921
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	14/551	204/9376	1.16778762321626	COL1A2/PTPN6/CAMK2D/MET/PRKACB/PXN/ERBB4/ARHGEF12/SDC2/ARHGEF1/ITGA2/PIK3CD/RRAS/ANK3	0.605406477580401
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	14/551	205/9376	1.16209109822496	GADD45B/GADD45A/CD3E/MAP2K6/SYK/HLA-E/IFNAR2/JUN/IRF3/IRAK4/ENTPD3/CCND3/ICAM1/PIK3CD	0.586316112518137
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	3/551	34/9376	1.50144122984947	DBP/CLOCK/PER3	0.731886350239776
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	3/551	35/9376	1.45854290899663	TPI1/SORD/FBP1	0.67908071702493
NA	NA	hsa04519	Cadherin signaling	26/551	404/9376	1.09511059998922	MYO1E/KRT8/KRT19/ARPC5L/DSP/GABRP/KRT18/EVL/LEF1/MYO1F/MET/WWC1/KRT23/PCDH7/TJP1/CELSR1/CTNNA2/CDH1/VCL/KRT7/YAP1/CTNND1/TAOK3/YWHAH/AFDN/RRAS	0.488291373784937
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	7/551	97/9376	1.22798286152637	FOS/RPS6KA5/CAMK2D/PLCB4/PRKACB/PER3/GNG11	0.563951246313585
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	20/551	308/9376	1.10495674923987	MT-ATP8/MT-ND4L/MT-ND2/TUBA1B/TUBB4B/COX6A2/BBC3/POLR2A/HIP1/NDUFV3/DNAH14/PLCB4/ATP5MC2/DNAH11/NDUFV1/TUBA1C/DNAH7/TFAM/TUBB/GPX3	0.467987285617829
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	6/551	83/9376	1.23009642927427	PEX11A/PHYH/PAOX/PECR/ECI2/PEX7	0.526108159480392
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	8/551	116/9376	1.17354027160648	DLGAP1/SLC38A2/GRIK4/HOMER2/PLCB4/PRKACB/PLD1/GNG11	0.469924247549151
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/551	22/9376	1.54693944893582	CNDP2/MAOA	0.641735385292569
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	5/551	69/9376	1.23306767668797	MAP2K6/SYK/LCP2/FCER1G/PIK3CD	0.485518537155911
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	7/551	101/9376	1.17934987691147	COL1A2/TGFBR1/JUN/PLCB4/EGR1/ICAM1/PIK3CD	0.452802578505651
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/551	38/9376	1.34339478460216	ENPP3/NMRK2/SIRT1	0.529983854042141
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/551	38/9376	1.34339478460216	SGK1/NR3C2/PIK3CD	0.529983854042141
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	3/551	38/9376	1.34339478460216	CD3E/CD8A/ZAP70	0.529983854042141
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	30/551	480/9376	1.06352087114338	MT-ATP8/MT-ND4L/ATF4/MT-ND2/TUBA1B/TUBB4B/DDIT3/SQSTM1/COX6A2/MAP2K6/C9orf72/CAMK2D/FUS/XBP1/HIP1/NDUFV3/DNAH14/PLCB4/UBA52/ATP5MC2/DNAH11/NDUFV1/TUBA1C/DNAH7/CHRM3/FRAT2/PRKN/TNFRSF1A/TUBB/GPX3	0.356979895161442
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	4/551	54/9376	1.26046918061437	MTAP/AMD1/ADI1/SDSL	0.479626041245917
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	6/551	86/9376	1.18718608871819	ATF4/CAMK2D/PLCB4/PRKACB/KCNMB2/CHRM3	0.435731561976156
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	5/551	70/9376	1.21545242416386	EGLN3/JUN/MET/EPAS1/PIK3CD	0.452087981192564
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	5/551	70/9376	1.21545242416386	HLA-E/PRF1/SGCD/ICAM1/SNTB1	0.452087981192564
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	12/551	184/9376	1.10976090901917	RGS3/SLIT2/CAMK2D/MET/SRGAP3/ARHGEF12/EFNB2/NFATC3/BMPR1B/PIK3CD/EFNA5/RRAS	0.375712530321967
NA	NA	hsa04382	Cornified envelope formation	14/551	217/9376	1.09782799601897	KRT8/KRT19/DSP/CLDN4/KRT18/CLDN3/PCSK6/S100A13/KRT23/TJP1/ABHD5/KRT7/CLDN12/SLC27A4	0.364311663283514
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	21/551	333/9376	1.07310214025278	COL1A2/MAML3/SPP1/ITGB8/ATM/RBL2/PATJ/MAML2/HLA-E/IFNAR2/IRF3/PRKACB/PXN/MAGI1/TADA3/ITGA2/TNFRSF1A/CCND3/COL9A2/PIK3CD/ATP6V1C2	0.339390767653324
Human Diseases	Immune disease	hsa05330	Allograft rejection	3/551	39/9376	1.30894876448415	HLA-E/PRF1/GZMB	0.483080122185167
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	5/551	71/9376	1.1983333759362	CCL5/JUN/MET/TJP1/ATP6V1C2	0.419151351205758
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	12/551	187/9376	1.09195725807234	TXNIP/HSP90AA1/CCL5/HSP90AB1/IL18/IFNAR2/JUN/IRF3/IRAK4/PLCB4/GBP3/CARD8	0.317377965144468
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	4/551	56/9376	1.21545242416386	MGAT4A/MGAT5/FUT8/ST6GAL1	0.404055965265572
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	9/551	138/9376	1.10976090901917	MT-ATP8/MT-ND4L/MT-ND2/COX6A2/NDUFV3/ATP5MC2/NDUFV1/PPA2/ATP6V1C2	0.324565489363346
Human Diseases	Cancer: specific types	hsa05218	Melanoma	5/551	73/9376	1.16550232454069	GADD45B/GADD45A/MET/CDH1/PIK3CD	0.35469747606554
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	4/551	57/9376	1.19412869742414	CBR4/SCD5/ACAA2/CPT2	0.367321706306974
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	11/551	173/9376	1.08196342960251	DNAJB1/CCL5/IL18/PRSS3/IFNAR2/IRF3/IRAK4/TNFRSF1A/CCND3/ICAM1/PIK3CD	0.271883306835167
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	7/551	107/9376	1.11321810811269	ATF4/CAMK2D/SIRT1/PLCB4/PRKACB/PYGL/FBP1	0.294303496535617
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	10/551	157/9376	1.08384292600599	FOS/ATF4/DDIT3/COX6A2/XBP1/NDUFV3/JUN/NDUFV1/TNFRSF1A/PIK3CD	0.264714923407573
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	5/551	75/9376	1.13442226255293	MGST1/ATM/BBC3/MGST2/PIK3CD	0.292039160363046
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	5/551	75/9376	1.13442226255293	ATF4/PLCB4/PRKACB/DUOX1/GPX3	0.292039160363046
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/551	10/9376	1.7016333938294	PAPSS1	0.554673291983638
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/551	26/9376	1.30894876448415	PLB1/SLC19A2	0.394158967754418
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	3/551	43/9376	1.18718608871819	ACAA2/CPT2/ECI2	0.307398146978025
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	7/551	110/9376	1.08285761425507	ID1/TGFBR1/ID3/SMAD9/ID4/BMPR1B/BAMBI	0.218417131724702
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	7/551	110/9376	1.08285761425507	HSP90AA1/HSP90AB1/PRKACB/CDC16/AURKA/PIK3CD/ANAPC4	0.218417131724702
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	5/551	77/9376	1.10495674923987	GADD45B/GADD45A/TGFBR1/PLD1/PIK3CD	0.231069002971976
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	3/551	44/9376	1.16020458670186	APTX/APEX1/POLG2	0.266144808844619
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	3/551	44/9376	1.16020458670186	HLA-E/PRF1/GZMB	0.266144808844619
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	5/551	78/9376	1.09079063707013	FOS/JUN/IRF3/IRAK4/IL23A	0.201185962244954
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	11/551	180/9376	1.03988707400686	CCL5/SRSF3/SYK/HLA-E/IFNAR2/IRF3/IRAK4/CGAS/TNFSF14/TNFRSF1A/PIK3CD	0.135012205205336
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/551	28/9376	1.21545242416386	CBR1/MOCOS	0.285282498455458
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	3/551	45/9376	1.13442226255293	DEFB1/ABCA1/ABCA7	0.225848621332061
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	14/551	232/9376	1.02684773765567	ITGAD/ITGAX/ARPC5L/PIP4K2A/ITGB8/SCIN/PXN/ARHGEF12/ARHGEF1/VCL/CHRM3/ITGA2/PIK3CD/RRAS	0.103463617685569
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	15/551	250/9376	1.02098003629764	HSPA1B/HSPA1A/HSPA6/ARPC5L/ARAP2/TGFBR1/HLA-E/ACAP1/PLD1/HSPA1L/CHMP4C/WASHC3/VPS28/HSPA8/CHMP3	0.084011760950315
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	4/551	63/9376	1.08040215481232	PLB1/TBXAS1/CBR1/PTGES3	0.159991622262562
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	4/551	63/9376	1.08040215481232	POLR2A/ERCC5/RPA2/GTF2H1	0.159991622262562
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	4/551	63/9376	1.08040215481232	GADD45B/GADD45A/LEF1/GLI1	0.159991622262562
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/551	12/9376	1.41802782819117	NCAM1	0.362050536115915
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	6/551	98/9376	1.04181636356902	ATF4/CAMK2D/PLCB4/PRKACB/NR4A1/NR4A2	0.10397674014159
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	9/551	150/9376	1.02098003629764	GADD45B/GADD45A/LEF1/TGFBR1/MET/CTNNA2/CDH1/FRAT2/PIK3CD	0.0647215963001375
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	8/551	133/9376	1.02353888350641	FOS/ATF4/CAMK2D/CLOCK/PLCB4/PRKACB/GNG11/MAOA	0.0683139321667421
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	3/551	47/9376	1.08614897478472	SOCS1/SOCS2/PIK3CD	0.147939987108736
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	6/551	99/9376	1.03129296595721	MAP2K6/CAMK2D/PLCB4/PRKACB/PTGER2/PIK3CD	0.0782104216477667
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	10/551	168/9376	1.01287702013655	HSP90AA1/FTL/SQSTM1/HSP90AB1/CAMK2D/IFNAR2/TNFRSF1A/PYGL/CHMP4C/CHMP3	0.0420815221965276
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	10/551	168/9376	1.01287702013655	SOCS1/PTPN6/CISH/IFNAR2/IL20RA/IL23A/SOCS2/CCND3/PIK3CD/IL10RB	0.0420815221965276
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	5/551	82/9376	1.03758133770085	UGT2B7/MGST1/MGST2/TK2/DPYD	0.0854047267258668
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	4/551	65/9376	1.04715901158732	ATF4/PLCB4/PRKACB/NR4A1	0.0953294944029055
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/551	13/9376	1.30894876448415	RAD50	0.278518923438927
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	10/551	170/9376	1.00096081989965	MGST1/GADD45B/GADD45A/LEF1/DPF3/TGFBR1/MGST2/MET/FRAT2/PIK3CD	0.00315889394379151
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/551	31/9376	1.09782799601897	RBKS/FBP1	0.136319640422561
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	9/551	154/9376	0.994461074315884	FOS/CAMK2D/JUN/PLCB4/PRKACB/PIK3R6/EEF2/NFATC3/CACNA2D4	-0.0173171899350784
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	4/551	67/9376	1.01590053362949	GAPDHS/GALM/TPI1/FBP1	0.0326363563522119
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	4/551	67/9376	1.01590053362949	ATF4/CAMK2D/PLCB4/PRKACB	0.0326363563522119
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	9/551	155/9376	0.988045196417072	TUBA1B/TUBB4B/HLA-E/CD36/CORO1A/TUBA1C/ITGA2/TUBB/ATP6V1C2	-0.0374993175205857
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	2/551	32/9376	1.06352087114338	MLST8/IGBP1	0.0899350748349065
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/551	32/9376	1.06352087114338	BBC3/TNFRSF1A	0.0899350748349065
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	6/551	103/9376	0.99124275368703	COL1A2/ARG2/PLCB4/PRKACB/VCL/PIK3CD	-0.0223295580859438
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	7/551	122/9376	0.976347029246378	SIRT1/CD36/SCD5/EEF2/STRADA/PIK3CD/FBP1	-0.0657059869584599
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/551	51/9376	1.00096081989965	PLB1/PLD1/PLPP1	0.00171912215632494
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	3/551	51/9376	1.00096081989965	PRKACB/TJP1/ATP6V1C2	0.00171912215632494
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	6/551	105/9376	0.972361939331086	ITGB8/SGCD/PRKACB/CACNA2D4/ITGA2/SNTB1	-0.0711611577881907
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/551	70/9376	0.972361939331086	UGT2B7/MGST1/MGST2/CBR1	-0.0579934762877583
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	6/551	106/9376	0.96318871348834	HSP90AA1/ATF4/HSP90AB1/LEF1/SPINT1/PIK3CD	-0.0952353411723264
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	8/551	142/9376	0.958666700748958	SOCS1/HERC4/UBA52/UBE2D2/PRKN/CDC16/UBE2S/ANAPC4	-0.124009052717581
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	7/551	125/9376	0.952914700544465	SGPP2/PLCB4/FCER1G/S1PR4/PLD1/TNFRSF1A/PIK3CD	-0.132418932791536
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	3/551	53/9376	0.96318871348834	PLCB4/PRKACB/VDR	-0.0671498688959541
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	8/551	144/9376	0.945351885460778	ID1/ID3/SMAD9/DLX5/ZFHX3/ID4/BMPR1B/PIK3CD	-0.165124916618384
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/551	16/9376	1.06352087114338	MAOA	0.0635393244435379
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	3/551	54/9376	0.945351885460778	HLA-E/PRF1/GZMB	-0.10062863781495
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	6/551	109/9376	0.936678932383157	CD36/TNFRSF1A/PYGL/TRIB3/PIK3CD/SLC27A4	-0.166148328563329
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4/551	73/9376	0.932401859632548	UGT2B7/MGST1/MGST2/MAOA	-0.14487343208986
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	7/551	128/9376	0.930580762250454	ENPP3/PAPSS1/ENTPD3/AK5/AK4/AK9/NUDT9	-0.197590015600677
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/551	36/9376	0.945351885460778	UGT2B7/SORD	-0.0820837285409296
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/551	36/9376	0.945351885460778	ENPP3/PYGL	-0.0820837285409296
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	3/551	55/9376	0.928163669361491	SGPP2/B4GALNT1/PLPP1	-0.133505240067505
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/551	17/9376	1.00096081989965	PCDH7	0.000990731124475539
Organismal Systems	Digestive system	hsa04970	Salivary secretion	5/551	93/9376	0.91485666334914	PLCB4/PRKACB/PRH1/CST3/CHRM3	-0.206182615843493
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	5/551	93/9376	0.91485666334914	GADD45B/GADD45A/CKS2/ITGA2/PIK3CD	-0.206182615843493
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	8/551	148/9376	0.919801834502379	FOS/GADD45B/GADD45A/LEF1/JUN/TNFSF11/FRAT2/PIK3CD	-0.245722870161723
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/551	37/9376	0.919801834502379	RIMKLB/ASRGL1	-0.122129109088791
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/551	37/9376	0.919801834502379	HGD/MAOA	-0.122129109088791
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	11/551	203/9376	0.922067356262237	COL1A2/SPP1/ITGB8/JUN/MET/PXN/VCL/ITGA2/CCND3/COL9A2/PIK3CD	-0.280488985737856
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	5/551	94/9376	0.905124145653937	FOS/HSP90AA1/HSP90AB1/JUN/FOSB	-0.230995183803697
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	8/551	149/9376	0.913628667827866	SYK/PLCB4/FCER1G/PIK3R6/PLD1/PIK3CD/PLPP1/RRAS	-0.265544048718839
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	8/551	149/9376	0.913628667827866	MT-ND4L/GABRP/MT-ND2/NDUFV3/PLCB4/PRKACB/NDUFV1/GNG11	-0.265544048718839
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	4/551	76/9376	0.895596523068106	CD36/SCD5/CPT2/SLC27A4	-0.228341244972133
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	4/551	76/9376	0.895596523068106	CAMK2D/PLCB4/PRKACB/CHRM3	-0.228341244972133
Human Diseases	Cancer: specific types	hsa05214	Glioma	4/551	76/9376	0.895596523068106	GADD45B/GADD45A/CAMK2D/PIK3CD	-0.228341244972133
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	2/551	38/9376	0.895596523068106	GALK2/GNPDA1	-0.161132782327694
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/551	18/9376	0.945351885460778	CBR4	-0.0579861127018917
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	4/551	78/9376	0.872632509656103	ZCCHC7/BTG2/TOB1/LSM2	-0.282237815819806
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	4/551	78/9376	0.872632509656103	FOS/PTPN6/JUN/IRAK4	-0.282237815819806
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	3/551	59/9376	0.865237318896306	MGST1/MGST2/GPX3	-0.259454783068745
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	3/551	59/9376	0.865237318896306	PRKACB/ABHD5/PIK3CD	-0.259454783068745
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	6/551	116/9376	0.880155203704863	HIBCH/TPI1/MCEE/ALDH6A1/FBP1/SDSL	-0.324523957467228
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	21/551	388/9376	0.920987146144779	MT-ATP8/MT-ND4L/ATF4/MT-ND2/TUBA1B/TUBB4B/DDIT3/COX6A2/SLC39A14/XBP1/BACE2/NDUFV3/PLCB4/ATP5MC2/NDUFV1/TUBA1C/CHRM3/FRAT2/TNFRSF1A/PIK3CD/TUBB	-0.397178891900249
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4/551	79/9376	0.861586528521216	UGT2B7/MGST1/MGST2/CBR1	-0.308691429468965
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	8/551	154/9376	0.883965399391897	UGT2B7/COQ7/AK5/ALAS1/AK4/PPCDC/AK9/COQ5	-0.362776706597409
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	5/551	99/9376	0.859410804964344	FOS/CDKN2C/JUN/PRKACB/PIK3CD	-0.35137417903733
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	5/551	99/9376	0.859410804964344	DEFB1/KRT19/KRT18/KRT23/ICAM1	-0.35137417903733
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	5/551	99/9376	0.859410804964344	ITGB8/SGCD/CACNA2D4/ITGA2/SNTB1	-0.35137417903733
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	8/551	156/9376	0.872632509656103	CLDN4/CLDN3/IFNAR2/IRF3/TNFRSF1A/CLDN12/PIK3CD/YWHAH	-0.400829346613885
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	7/551	138/9376	0.86314737368158	SOCS1/PRKACB/SOCS2/PYGL/FLOT1/PIK3CD/FBP1	-0.40467630988677
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	3/551	62/9376	0.823370997014226	MAML3/MAML2/CTBP2	-0.348653336834427
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	6/551	120/9376	0.850816696914701	ATF4/RPS6KA5/CAMK2D/JUN/IRAK4/PIK3CD	-0.410963498016664
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	13/551	250/9376	0.884849364791289	MEAK7/FUCA1/DEPTOR/CLN3/BORCS6/CTSF/DTNBP1/DNASE2/TPCN1/OSBPL5/MLST8/VPS41/ATP6V1C2	-0.461105381381971
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	8/551	158/9376	0.861586528521216	SGK1/DDIT4/DEPTOR/STRADA/TNFRSF1A/MLST8/PIK3CD/ATP6V1C2	-0.438422297176943
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/551	21/9376	0.810301616109239	DSE	-0.217448022773987
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	5/551	102/9376	0.83413401658304	PRSS3/PLCB4/CHRM3/RAB27B/SCT	-0.420850598062574
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	4/551	83/9376	0.820064286182844	CBX4/UBE2D2/MBD5/MBD6	-0.411417280658001
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	12/551	235/9376	0.868919179827779	MT-ATP8/MT-ND4L/MT-ND2/COX6A2/DPF3/SLC25A29/NDUFV3/PRKACB/ATP5MC2/CPT2/NDUFV1/MLST8	-0.508487530562407
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	2/551	44/9376	0.77346972446791	GTF2H1/GTF2B	-0.376330404267416
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	2/551	44/9376	0.77346972446791	DYNLL1/PRKACB	-0.376330404267416
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	3/551	65/9376	0.785369258690493	SPP1/PLCB4/PIK3CD	-0.433864904366569
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	7/551	144/9376	0.827182899778181	LEF1/MAP2K6/SIRT1/IRF3/SCD5/IRAK4/TNFRSF1A	-0.522184699416807
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/551	23/9376	0.739840606012783	ARG2	-0.31212750706492
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/551	23/9376	0.739840606012783	ST3GAL3	-0.31212750706492
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/551	23/9376	0.739840606012783	RPA2	-0.31212750706492
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	4/551	86/9376	0.791457392478791	CAMK2D/JUN/ERBB4/PIK3CD	-0.485445241876931
Organismal Systems	Sensory system	hsa04742	Taste transduction	4/551	86/9376	0.791457392478791	PLCB4/PRKACB/CHRM3/PKD1L3	-0.485445241876931
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/551	66/9376	0.77346972446791	UGT2B7/HSD17B2/SULT1E1	-0.461452986541709
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	3/551	66/9376	0.77346972446791	IL18/JUN/IL23A	-0.461452986541709
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	3/551	68/9376	0.750720614924736	LEF1/DUSP6/PIK3CD	-0.515485809455113
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	2/551	47/9376	0.724099316523149	ACYP2/GRHPR	-0.4737925629278
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	4/551	89/9376	0.764779053406472	SLC38A2/GABRP/PRKACB/GNG11	-0.557105382587622
Organismal Systems	Endocrine system	hsa04924	Renin secretion	3/551	69/9376	0.739840606012783	PLCB4/PRKACB/PTGER2	-0.541955067262061
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	5/551	110/9376	0.77346972446791	EGLN3/CAMK2D/TIMP1/EPAS1/PIK3CD	-0.597146001310267
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/551	48/9376	0.709013914095584	PLCB4/PIK3CD	-0.505013111104091
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	4/551	90/9376	0.756281508368623	ATF4/SIRT1/PRKACB/PIK3CD	-0.580496328495819
Organismal Systems	Digestive system	hsa04976	Bile secretion	4/551	90/9376	0.756281508368623	SLC10A1/UGT2B7/PRKACB/SCT	-0.580496328495819
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	2/551	49/9376	0.694544242379347	ST3GAL3/ST6GAL1	-0.535647950944629
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/551	26/9376	0.654474382242077	PLB1	-0.440823969811199
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	3/551	72/9376	0.709013914095584	IRF3/DDX3X/CASP10	-0.619309441193109
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/551	27/9376	0.630234590307186	SCD5	-0.480761481400418
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	6/551	134/9376	0.76192540022212	PLCB4/PRKACB/ARHGEF12/ARHGEF1/KCNMB2/ADM	-0.693564028681045
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	7/551	154/9376	0.77346972446791	ATF4/RPS6KA5/CAMK2D/PLCB4/PRKACB/PIK3R6/CACNA2D4	-0.708236223259739
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	7/551	155/9376	0.768479597213278	ATF4/LEF1/CAMK2D/CDKN2C/PLCB4/PRKACB/NR4A1	-0.726223315704744
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	5/551	115/9376	0.739840606012783	DUSP1/PLCB4/PRKACB/GNG11/MAOA	-0.701396462117325
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	11/551	233/9376	0.803346237430189	COL1A2/DSP/ITGB8/SGCD/NEBL/SDC2/VCL/ITGA2/COL9A2/SNTB1/ANK3	-0.759521271452577
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/551	28/9376	0.607726212081929	ATP6V1C2	-0.519413261327446
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	2/551	52/9376	0.654474382242077	PRKACB/HSD17B2	-0.624287834765677
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	3/551	75/9376	0.68065335753176	ARG2/TPI1/SDSL	-0.693796723548357
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	6/551	138/9376	0.739840606012783	CAMK2D/PRKACB/CDC16/AURKA/YWHAH/ANAPC4	-0.769297209511829
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	2/551	54/9376	0.630234590307186	RPA2/RMI1	-0.680883316875817
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	11/551	238/9376	0.786469215635437	RASSF1/MET/PRKACB/RALGAPA2/PLD1/GNG11/PIK3CD/ZAP70/AFDN/EFNA5/RRAS	-0.833733932937661
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	4/551	98/9376	0.694544242379347	PIP4K2A/PLCB4/PIK3CD/INPP5F	-0.759518313505485
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/551	30/9376	0.567211131276467	PLB1	-0.593236551748047
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/551	31/9376	0.548913998009484	UGT2B7	-0.628571412002292
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/551	31/9376	0.548913998009484	SEC11A	-0.628571412002292
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	2/551	56/9376	0.607726212081929	PRKACB/GLI1	-0.73566386937041
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	4/551	101/9376	0.673914215377981	LEF1/CAMK2D/PLCB4/PRKACB	-0.823265042795515
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/551	32/9376	0.531760435571688	GALM	-0.662949980211596
Human Diseases	Immune disease	hsa05310	Asthma	1/551	32/9376	0.531760435571688	FCER1G	-0.662949980211596
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	10/551	226/9376	0.752935130013009	FOS/CAMK2D/JUN/PRKACB/PTGER2/PLD1/GLI1/PIK3CD/AFDN/RRAS	-0.939417726340984
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/551	33/9376	0.515646482978606	SNAP23	-0.696434590842271
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	4/551	104/9376	0.654474382242077	PLB1/CHKB/PLD1/PLPP1	-0.885348571466048
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/551	34/9376	0.500480409949824	POLR2A	-0.729081590966981
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	2/551	60/9376	0.567211131276467	PXN/PIK3CD	-0.840312933791941
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/551	36/9376	0.472675942730389	RPA2	-0.792062546621884
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	2/551	63/9376	0.540201077406159	MECOM/NSD1	-0.914950298435241
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	3/551	87/9376	0.586770135803242	COX6A2/CACNA2D4/ASPH	-0.967544449772461
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/551	37/9376	0.459900917251189	GALK2	-0.822485394603472
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	2/551	65/9376	0.523579505793662	LIPC/PLPP1	-0.963059303136043
Human Diseases	Substance dependence	hsa05032	Morphine addiction	3/551	91/9376	0.560978041921781	GABRP/PRKACB/GNG11	-1.05152612015537
Genetic Information Processing	Transcription	hsa03040	Spliceosome	10/551	243/9376	0.700260655896873	HSPA1B/HSPA1A/HSPA6/SRSF3/FUS/PRPF6/HSPA1L/RBM22/LSM2/HSPA8	-1.18288967553162
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/551	68/9376	0.500480409949824	UGT2B7/CYP26A1	-1.03295850211584
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/551	41/9376	0.415032535080342	GABRP	-0.937930286318869
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/551	42/9376	0.405150808054619	MAOA	-0.965387571771006
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	2/551	70/9376	0.486180969665543	CD36/TNFRSF1A	-1.0781563912484
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	2/551	71/9376	0.479333350374479	MET/PIK3CD	-1.10036008154531
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	6/551	166/9376	0.615048214637133	ATF4/MEF2A/PLCB4/PIK3R6/KCNMB2/NFATC3	-1.25035877894663
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	5/551	144/9376	0.590844928412986	XBP1/FGF14/PLCB4/PIK3CD/GTF2B	-1.23630426501365
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	4/551	122/9376	0.557912588140787	PLCB4/PRKACB/THRB/PIK3CD	-1.22808208832171
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	10/551	254/9376	0.669934407019449	CAMK2D/MET/PLCB4/PRKACB/ORAI3/ERBB4/NFATC3/TPCN1/CHRM3/ASPH	-1.33252743545173
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	3/551	103/9376	0.495621376843515	UPF2/FUS/PCF11	-1.28608370263609
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	2/551	80/9376	0.42540834845735	MET/PIK3CD	-1.28961574921995
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	2/551	88/9376	0.386734862233955	ITGAX/CD59	-1.44421745753197
Organismal Systems	Nervous system	hsa04730	Long-term depression	1/551	60/9376	0.283605565638233	PLCB4	-1.39096809644453
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	14/551	370/9376	0.643861284151665	RXFP1/GABRP/GRIK4/GAL/PTGDR/PRSS3/S1PR4/PTGER2/PYY/THRB/ADM/CHRM3/CHRNA5/SCT	-1.74645805560533
NA	NA	hsa04081	Hormone signaling	7/551	219/9376	0.543901084785653	SMAD9/PLCB4/PRKACB/THRB/GNG11/BMPR1B/PIK3CD	-1.70650894963155
NA	NA	hsa04082	Neuroactive ligand signaling	6/551	199/9376	0.51305529462193	GABRP/GRIK4/PLCB4/PRKACB/CHRM3/GNG11	-1.73484189315829
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	11/551	323/9376	0.57950363257348	SPRY2/RPS6KA5/SOCS1/ATM/RASSF1/DDIT4/SIRT1/MET/SOX4/PIK3CD/EFNA5	-1.92163690145073
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	1/551	73/9376	0.233100464908137	APOBEC3H	-1.64358615655606
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	2/551	108/9376	0.315117295153593	RANBP17/UPF2	-1.78870674641847
Human Diseases	Substance dependence	hsa05034	Alcoholism	5/551	191/9376	0.445453768018168	ATF4/PRKACB/FOSB/GNG11/MAOA	-1.93472365940867
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	1/551	79/9376	0.215396632130304	ATP6V1C2	-1.74983209803379
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	2/551	117/9376	0.290877503218701	MORF4L2/DPF3	-1.92857366866371
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	3/551	195/9376	0.261789752896831	SYK/PLCB4/PIK3CD	-2.6028938778841
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	2/551	183/9376	0.185970862713596	IMP3/RPP25L	-2.77869542271679
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	3/551	449/9376	0.113694881547621	CAMK2D/NCALD/PRKACB	-4.80903282108167