ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003735 structural constituent of ribosome 51/1109 175/18639 0.291428571428571 4.89804972304521 4.03671260563058e-22 4.3959800275317e-19 GO:0140416 transcription regulator inhibitor activity 11/1109 33/18639 0.333333333333333 5.60234445446348 1.80905065399233e-06 0.000985028081098824 GO:0140662 ATP-dependent protein folding chaperone 11/1109 40/18639 0.275 4.62193417493237 1.47050342023534e-05 0.00533792741545428 GO:0019843 rRNA binding 14/1109 65/18639 0.215384615384615 3.61997641673025 2.25146237102362e-05 0.0061296063051118 GO:0003714 transcription corepressor activity 27/1109 204/18639 0.132352941176471 2.22446029809579 8.07078747962383e-05 0.0175781751306207 GO:0044183 protein folding chaperone 14/1109 75/18639 0.186666666666667 3.13731289449955 0.00011870727280768 0.0187173228405072 GO:0031625 ubiquitin protein ligase binding 35/1109 302/18639 0.115894039735099 1.94783499244591 0.0001245913906928 0.0187173228405072 GO:0055105 ubiquitin-protein transferase inhibitor activity 6/1109 15/18639 0.4 6.72281334535618 0.000137500994236967 0.0187173228405072 GO:1990948 ubiquitin ligase inhibitor activity 5/1109 11/18639 0.454545454545455 7.63956061972293 0.000252380167647769 0.0305380002853801 GO:0051082 unfolded protein binding 18/1109 121/18639 0.148760330578512 2.50021983918205 0.000285826876025733 0.0311265467992024 GO:0044389 ubiquitin-like protein ligase binding 35/1109 322/18639 0.108695652173913 1.82685145254244 0.000426469367135659 0.0422204673464302 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 47/1109 484/18639 0.0971074380165289 1.63208795057717 0.000657373882147154 0.0596566798048542 GO:0031072 heat shock protein binding 18/1109 131/18639 0.137404580152672 2.30936336290861 0.000758459987964916 0.0635356097610611 GO:0001216 DNA-binding transcription activator activity 47/1109 491/18639 0.0957230142566191 1.6088198942553 0.000892888187491507 0.0694539454413036 GO:0055106 ubiquitin-protein transferase regulator activity 8/1109 36/18639 0.222222222222222 3.73489630297565 0.00103955390419357 0.0754716134444535 GO:0045296 cadherin binding 34/1109 334/18639 0.101796407185629 1.71089561184214 0.00160099731892587 0.108967880019392 GO:1990841 promoter-specific chromatin binding 11/1109 68/18639 0.161764705882353 2.71878480878375 0.00211921112114683 0.135754171231111 GO:0048027 mRNA 5'-UTR binding 6/1109 24/18639 0.25 4.20175834084761 0.00233075501862731 0.141010678626952 GO:0051087 protein-folding chaperone binding 17/1109 134/18639 0.126865671641791 2.13223557595252 0.00252480514960716 0.144711200416958 GO:0019887 protein kinase regulator activity 27/1109 255/18639 0.105882352941176 1.77956823847663 0.00267357333289009 0.145576067975865 GO:0098641 cadherin binding involved in cell-cell adhesion 5/1109 18/18639 0.277777777777778 4.66862037871957 0.00329993247452996 0.171125069750625 GO:0004859 phospholipase inhibitor activity 4/1109 12/18639 0.333333333333333 5.60234445446348 0.00419597257837844 0.201785957473532 GO:0050145 nucleoside monophosphate kinase activity 5/1109 19/18639 0.263157894736842 4.4229035166817 0.00426177871615357 0.201785957473532 GO:0003712 transcription coregulator activity 44/1109 495/18639 0.0888888888888889 1.49395852119026 0.00514623171502605 0.233510264069307 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 4/1109 13/18639 0.307692307692308 5.17139488104321 0.00577818897670101 0.251697911825096 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 12/1109 89/18639 0.134831460674157 2.26611685798523 0.00634880227123907 0.254920360653011 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 12/1109 89/18639 0.134831460674157 2.26611685798523 0.00634880227123907 0.254920360653011 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 8/1109 48/18639 0.166666666666667 2.80117222723174 0.00690001258358688 0.254920360653011 GO:0140793 histone H2AXY142 phosphatase activity 12/1109 90/18639 0.133333333333333 2.24093778178539 0.00693993412687217 0.254920360653011 GO:0019207 kinase regulator activity 28/1109 287/18639 0.0975609756097561 1.63971057203809 0.0070225994670251 0.254920360653011 GO:0044548 S100 protein binding 4/1109 14/18639 0.285714285714286 4.80200953239727 0.00771304442443602 0.258282765490381 GO:0001786 phosphatidylserine binding 9/1109 59/18639 0.152542372881356 2.56378475034769 0.00774133356104963 0.258282765490381 GO:0060590 ATPase regulator activity 8/1109 49/18639 0.163265306122449 2.74400544708415 0.00782675046940547 0.258282765490381 GO:0004857 enzyme inhibitor activity 37/1109 416/18639 0.0889423076923077 1.49485633280155 0.00963564113365502 0.306260198154481 GO:0042287 MHC protein binding 7/1109 41/18639 0.170731707317073 2.86949350106666 0.00984307340257744 0.306260198154481 GO:0008013 beta-catenin binding 13/1109 106/18639 0.122641509433962 2.06123994079317 0.0101564995606604 0.307234111709977 GO:0140297 DNA-binding transcription factor binding 42/1109 488/18639 0.0860655737704918 1.4465069698 0.0104998035722366 0.309034759193665 GO:0030296 protein tyrosine kinase activator activity 6/1109 33/18639 0.181818181818182 3.05582424788917 0.0121558989756114 0.348362473274759 GO:0055102 lipase inhibitor activity 4/1109 16/18639 0.25 4.20175834084761 0.0127532429484158 0.354977825466908 GO:0004536 DNA nuclease activity 9/1109 64/18639 0.140625 2.36348906672678 0.0130386712751848 0.354977825466908 GO:0004725 protein tyrosine phosphatase activity 12/1109 98/18639 0.122448979591837 2.05800408531312 0.0133702468491476 0.355126800456629 GO:0019205 nucleobase-containing compound kinase activity 7/1109 44/18639 0.159090909090909 2.67384621690302 0.0143852879352538 0.372989965749795 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 4/1109 17/18639 0.235294117647059 3.95459608550363 0.0159066466079552 0.393689503546892 GO:0019198 transmembrane receptor protein phosphatase activity 4/1109 17/18639 0.235294117647059 3.95459608550363 0.0159066466079552 0.393689503546892 GO:0004435 phosphatidylinositol phospholipase C activity 5/1109 26/18639 0.192307692307692 3.23212180065201 0.0170790878888105 0.405760241628679 GO:0042578 phosphoric ester hydrolase activity 32/1109 363/18639 0.0881542699724518 1.48161175655233 0.0171395510697146 0.405760241628679 GO:0046332 SMAD binding 10/1109 79/18639 0.126582278481013 2.12747257764436 0.0184246427162509 0.426902891872281 GO:0016854 racemase and epimerase activity 4/1109 18/18639 0.222222222222222 3.73489630297565 0.019508564931791 0.436929932155324 GO:0001671 ATPase activator activity 5/1109 27/18639 0.185185185185185 3.11241358581304 0.0199606389790508 0.436929932155324 GO:0001784 phosphotyrosine residue binding 7/1109 47/18639 0.148936170212766 2.50317518178155 0.0202542992110329 0.436929932155324 GO:0001618 virus receptor activity 10/1109 81/18639 0.123456790123457 2.07494239054203 0.0216142513455651 0.436929932155324 GO:0051213 dioxygenase activity 11/1109 93/18639 0.118279569892473 1.98792867739027 0.0220368340527431 0.436929932155324 GO:0051219 phosphoprotein binding 11/1109 93/18639 0.118279569892473 1.98792867739027 0.0220368340527431 0.436929932155324 GO:0051959 dynein light intermediate chain binding 5/1109 28/18639 0.178571428571429 3.00125595774829 0.0231426797969756 0.436929932155324 GO:0097718 disordered domain specific binding 5/1109 28/18639 0.178571428571429 3.00125595774829 0.0231426797969756 0.436929932155324 GO:0140272 exogenous protein binding 10/1109 82/18639 0.121951219512195 2.04963821504761 0.0233513490842041 0.436929932155324 GO:0042162 telomeric DNA binding 6/1109 38/18639 0.157894736842105 2.65374211000902 0.0235787585380745 0.436929932155324 GO:0003779 actin binding 37/1109 443/18639 0.0835214446952596 1.4037477075518 0.0236361272135067 0.436929932155324 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 3/1109 11/18639 0.272727272727273 4.58373637183376 0.0241814686350383 0.436929932155324 GO:0032794 GTPase activating protein binding 3/1109 11/18639 0.272727272727273 4.58373637183376 0.0241814686350383 0.436929932155324 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 8/1109 60/18639 0.133333333333333 2.24093778178539 0.0250896855336952 0.436929932155324 GO:0030695 GTPase regulator activity 40/1109 489/18639 0.081799591002045 1.37480845508306 0.0258540389975121 0.436929932155324 GO:0060589 nucleoside-triphosphatase regulator activity 40/1109 490/18639 0.0816326530612245 1.37200272354208 0.0265988180226409 0.436929932155324 GO:0004629 phospholipase C activity 5/1109 29/18639 0.172413793103448 2.89776437299835 0.0266348432146308 0.436929932155324 GO:0004860 protein kinase inhibitor activity 10/1109 84/18639 0.119047619047619 2.00083730516553 0.0271240678864619 0.436929932155324 GO:1901981 phosphatidylinositol phosphate binding 18/1109 185/18639 0.0972972972972973 1.63527892184339 0.0274630289521004 0.436929932155324 GO:0031418 L-ascorbic acid binding 4/1109 20/18639 0.2 3.36140667267809 0.0281159980683231 0.436929932155324 GO:0042288 MHC class I protein binding 4/1109 20/18639 0.2 3.36140667267809 0.0281159980683231 0.436929932155324 GO:0030544 Hsp70 protein binding 7/1109 51/18639 0.137254901960784 2.30684771654379 0.0304222823760142 0.436929932155324 GO:0016208 AMP binding 3/1109 12/18639 0.25 4.20175834084761 0.0308433006539249 0.436929932155324 GO:0031543 peptidyl-proline dioxygenase activity 3/1109 12/18639 0.25 4.20175834084761 0.0308433006539249 0.436929932155324 GO:0035259 nuclear glucocorticoid receptor binding 3/1109 12/18639 0.25 4.20175834084761 0.0308433006539249 0.436929932155324 GO:0043047 single-stranded telomeric DNA binding 3/1109 12/18639 0.25 4.20175834084761 0.0308433006539249 0.436929932155324 GO:0045295 gamma-catenin binding 3/1109 12/18639 0.25 4.20175834084761 0.0308433006539249 0.436929932155324 GO:0097371 MDM2/MDM4 family protein binding 3/1109 12/18639 0.25 4.20175834084761 0.0308433006539249 0.436929932155324 GO:0140789 histone phosphatase activity 14/1109 136/18639 0.102941176470588 1.73013578740784 0.031856528600438 0.436929932155324 GO:0017080 sodium channel regulator activity 6/1109 41/18639 0.146341463414634 2.45956585805714 0.0330693178825921 0.436929932155324 GO:0042169 SH2 domain binding 6/1109 41/18639 0.146341463414634 2.45956585805714 0.0330693178825921 0.436929932155324 GO:0008373 sialyltransferase activity 4/1109 21/18639 0.19047619047619 3.20133968826485 0.0331419831380785 0.436929932155324 GO:0070182 DNA polymerase binding 4/1109 21/18639 0.19047619047619 3.20133968826485 0.0331419831380785 0.436929932155324 GO:0030159 signaling receptor complex adaptor activity 7/1109 52/18639 0.134615384615385 2.26248526045641 0.0334170940190384 0.436929932155324 GO:0008081 phosphoric diester hydrolase activity 10/1109 87/18639 0.114942528735632 1.93184291533223 0.033568858418723 0.436929932155324 GO:0016922 nuclear receptor binding 14/1109 137/18639 0.102189781021898 1.7175070590326 0.0336203804716504 0.436929932155324 GO:0005096 GTPase activator activity 24/1109 271/18639 0.0885608856088561 1.48844575911945 0.0337025842984823 0.436929932155324 GO:0043022 ribosome binding 12/1109 112/18639 0.107142857142857 1.80075357464898 0.0343567707190254 0.437897494374723 GO:0070273 phosphatidylinositol-4-phosphate binding 5/1109 31/18639 0.161290322580645 2.71081183280491 0.0345814366540185 0.437897494374723 GO:0004520 DNA endonuclease activity 6/1109 42/18639 0.142857142857143 2.40100476619863 0.0367107770643847 0.459517657736953 GO:0035325 Toll-like receptor binding 3/1109 13/18639 0.230769230769231 3.87854616078241 0.0383628341570922 0.469405914573858 GO:0140666 annealing activity 3/1109 13/18639 0.230769230769231 3.87854616078241 0.0383628341570922 0.469405914573858 GO:0005126 cytokine receptor binding 24/1109 275/18639 0.0872727272727273 1.4667956389868 0.0389709684490755 0.471548718233813 GO:0019210 kinase inhibitor activity 10/1109 90/18639 0.111111111111111 1.86744815148783 0.0410143471801074 0.490820044825681 GO:0035591 signaling adaptor activity 13/1109 129/18639 0.10077519379845 1.69373204437268 0.0435608729854893 0.496329245945104 GO:0051015 actin filament binding 19/1109 209/18639 0.0909090909090909 1.52791212394459 0.0436004790840876 0.496329245945104 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 29/1109 349/18639 0.0830945558739255 1.39657297288918 0.0436534509869996 0.496329245945104 GO:0072341 modified amino acid binding 10/1109 91/18639 0.10989010989011 1.84692674322972 0.0437286473981336 0.496329245945104 GO:0004602 glutathione peroxidase activity 4/1109 23/18639 0.173913043478261 2.9229623240679 0.0446650744743987 0.496329245945104 GO:0043274 phospholipase binding 4/1109 23/18639 0.173913043478261 2.9229623240679 0.0446650744743987 0.496329245945104 GO:0140103 catalytic activity, acting on a glycoprotein 4/1109 23/18639 0.173913043478261 2.9229623240679 0.0446650744743987 0.496329245945104 GO:0019763 immunoglobulin receptor activity 3/1109 14/18639 0.214285714285714 3.60150714929795 0.0467218677205438 0.508801139476722 GO:0098847 sequence-specific single stranded DNA binding 3/1109 14/18639 0.214285714285714 3.60150714929795 0.0467218677205438 0.508801139476722 GO:0048306 calcium-dependent protein binding 9/1109 80/18639 0.1125 1.89079125338143 0.0476644007061013 0.513926063058855 GO:0004715 non-membrane spanning protein tyrosine kinase activity 6/1109 45/18639 0.133333333333333 2.24093778178539 0.0491308812348662 0.519451744318149 GO:0008009 chemokine activity 6/1109 45/18639 0.133333333333333 2.24093778178539 0.0491308812348662 0.519451744318149 GO:0001664 G protein-coupled receptor binding 25/1109 297/18639 0.0841750841750842 1.41473344809684 0.0510233107426654 0.527116323684617 GO:0035035 histone acetyltransferase binding 4/1109 24/18639 0.166666666666667 2.80117222723174 0.0511635734267548 0.527116323684617 GO:0004601 peroxidase activity 7/1109 57/18639 0.12280701754386 2.06402164111812 0.0513079249867488 0.527116323684617 GO:0035091 phosphatidylinositol binding 24/1109 284/18639 0.0845070422535211 1.42031267859638 0.0530204887390409 0.533796830207573 GO:0030291 protein serine/threonine kinase inhibitor activity 6/1109 46/18639 0.130434782608696 2.19222174305093 0.0537795066499776 0.533796830207573 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 7/1109 58/18639 0.120689655172414 2.02843506109885 0.0554896050579811 0.533796830207573 GO:0004867 serine-type endopeptidase inhibitor activity 10/1109 95/18639 0.105263157894737 1.76916140667268 0.0557966725427789 0.533796830207573 GO:0000774 adenyl-nucleotide exchange factor activity 3/1109 15/18639 0.2 3.36140667267809 0.0558949626913427 0.533796830207573 GO:0140776 protein-containing complex destabilizing activity 3/1109 15/18639 0.2 3.36140667267809 0.0558949626913427 0.533796830207573 GO:0005085 guanyl-nucleotide exchange factor activity 20/1109 230/18639 0.0869565217391304 1.46148116203395 0.0573433989842664 0.533796830207573 GO:0004721 phosphoprotein phosphatase activity 16/1109 175/18639 0.0914285714285714 1.53664305036713 0.0578247455017122 0.533796830207573 GO:0008135 translation factor activity, RNA binding 9/1109 83/18639 0.108433734939759 1.82244940084957 0.0578627778667276 0.533796830207573 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 4/1109 25/18639 0.16 2.68912533814247 0.0581495657773632 0.533796830207573 GO:0042974 nuclear retinoic acid receptor binding 4/1109 25/18639 0.16 2.68912533814247 0.0581495657773632 0.533796830207573 GO:0047617 fatty acyl-CoA hydrolase activity 4/1109 25/18639 0.16 2.68912533814247 0.0581495657773632 0.533796830207573 GO:0004620 phospholipase activity 11/1109 109/18639 0.100917431192661 1.69612263300271 0.0595528956121488 0.533796830207573 GO:0004879 nuclear receptor activity 7/1109 59/18639 0.11864406779661 1.99405480582598 0.0598771638814835 0.533796830207573 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 7/1109 59/18639 0.11864406779661 1.99405480582598 0.0598771638814835 0.533796830207573 GO:0045309 protein phosphorylated amino acid binding 7/1109 59/18639 0.11864406779661 1.99405480582598 0.0598771638814835 0.533796830207573 GO:0045505 dynein intermediate chain binding 5/1109 36/18639 0.138888888888889 2.33431018935978 0.0602911020344642 0.533796830207573 GO:0180051 translation factor activity 9/1109 84/18639 0.107142857142857 1.80075357464898 0.0615514230643596 0.539183912794378 GO:0043021 ribonucleoprotein complex binding 16/1109 177/18639 0.0903954802259887 1.51927985205789 0.0627727949770667 0.539183912794378 GO:0042379 chemokine receptor binding 8/1109 72/18639 0.111111111111111 1.86744815148783 0.0634693161041428 0.539183912794378 GO:0098531 ligand-modulated transcription factor activity 7/1109 60/18639 0.116666666666667 1.96082055906222 0.0644717364934555 0.539183912794378 GO:0004529 DNA exonuclease activity 4/1109 26/18639 0.153846153846154 2.58569744052161 0.0656169253934637 0.539183912794378 GO:0016289 acyl-CoA hydrolase activity 4/1109 26/18639 0.153846153846154 2.58569744052161 0.0656169253934637 0.539183912794378 GO:0052742 phosphatidylinositol kinase activity 4/1109 26/18639 0.153846153846154 2.58569744052161 0.0656169253934637 0.539183912794378 GO:0005159 insulin-like growth factor receptor binding 3/1109 16/18639 0.1875 3.15131875563571 0.0658507441704796 0.539183912794378 GO:0017070 U6 snRNA binding 3/1109 16/18639 0.1875 3.15131875563571 0.0658507441704796 0.539183912794378 GO:0140328 floppase activity 3/1109 16/18639 0.1875 3.15131875563571 0.0658507441704796 0.539183912794378 GO:0023023 MHC protein complex binding 5/1109 37/18639 0.135135135135135 2.27122072478249 0.066450042376372 0.54003056826768 GO:0035254 glutamate receptor binding 6/1109 49/18639 0.122448979591837 2.05800408531312 0.0692730719798395 0.558802780637372 GO:0030295 protein kinase activator activity 13/1109 139/18639 0.0935251798561151 1.57188081815882 0.0707197311918448 0.566277847558228 GO:0000146 microfilament motor activity 5/1109 38/18639 0.131578947368421 2.21145175834085 0.0729456914427807 0.579838379424732 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 4/1109 27/18639 0.148148148148148 2.48993086865044 0.0735571491177093 0.580461850646272 GO:0048020 CCR chemokine receptor binding 6/1109 50/18639 0.12 2.01684400360685 0.0749539544099336 0.582980925254694 GO:0004550 nucleoside diphosphate kinase activity 3/1109 17/18639 0.176470588235294 2.96594706412773 0.0765530507910204 0.582980925254694 GO:0008569 minus-end-directed microtubule motor activity 3/1109 17/18639 0.176470588235294 2.96594706412773 0.0765530507910204 0.582980925254694 GO:0016805 dipeptidase activity 3/1109 17/18639 0.176470588235294 2.96594706412773 0.0765530507910204 0.582980925254694 GO:0046965 nuclear retinoid X receptor binding 3/1109 17/18639 0.176470588235294 2.96594706412773 0.0765530507910204 0.582980925254694 GO:0016776 phosphotransferase activity, phosphate group as acceptor 5/1109 39/18639 0.128205128205128 2.15474786710134 0.0797746508680618 0.599257517903011 GO:0035401 histone H3Y41 kinase activity 11/1109 115/18639 0.0956521739130435 1.60762927823735 0.0806663520327488 0.599257517903011 GO:0140801 histone H2AXY142 kinase activity 11/1109 115/18639 0.0956521739130435 1.60762927823735 0.0806663520327488 0.599257517903011 GO:0003743 translation initiation factor activity 6/1109 51/18639 0.117647058823529 1.97729804275182 0.0808915106811227 0.599257517903011 GO:0098631 cell adhesion mediator activity 8/1109 76/18639 0.105263157894737 1.76916140667268 0.0816274841848137 0.600623853224744 GO:0016887 ATP hydrolysis activity 32/1109 417/18639 0.0767386091127098 1.28974836361749 0.0843025004671394 0.616143778581979 GO:0003746 translation elongation factor activity 3/1109 18/18639 0.166666666666667 2.80117222723174 0.0879619479628664 0.634374578354712 GO:0008525 phosphatidylcholine transporter activity 3/1109 18/18639 0.166666666666667 2.80117222723174 0.0879619479628664 0.634374578354712 GO:0016791 phosphatase activity 22/1109 273/18639 0.0805860805860806 1.35441294503513 0.091717219177582 0.657105603186755 GO:0001727 lipid kinase activity 5/1109 41/18639 0.121951219512195 2.04963821504761 0.0944133920338388 0.672001202123205 GO:0008235 metalloexopeptidase activity 7/1109 66/18639 0.106060606060606 1.78256414460202 0.096394270630368 0.678751823095175 GO:0005525 GTP binding 29/1109 378/18639 0.0767195767195767 1.28942848555112 0.0966083862073022 0.678751823095175 GO:0008301 DNA binding, bending 3/1109 19/18639 0.157894736842105 2.65374211000902 0.100034617970411 0.690769655220614 GO:0001965 G-protein alpha-subunit binding 4/1109 30/18639 0.133333333333333 2.24093778178539 0.10009860385944 0.690769655220614 GO:0051287 NAD binding 6/1109 54/18639 0.111111111111111 1.86744815148783 0.100221859986095 0.690769655220614 GO:0051879 Hsp90 protein binding 5/1109 42/18639 0.119047619047619 2.00083730516553 0.102211042705387 0.700049217019912 GO:0019209 kinase activator activity 13/1109 148/18639 0.0878378378378378 1.47629347110862 0.103006846929984 0.701090351917205 GO:0003697 single-stranded DNA binding 11/1109 121/18639 0.0909090909090909 1.52791212394459 0.105919399987015 0.716436189974279 GO:0098632 cell-cell adhesion mediator activity 6/1109 55/18639 0.109090909090909 1.8334945487335 0.107160604989557 0.720357400207581 GO:0043024 ribosomal small subunit binding 3/1109 20/18639 0.15 2.52105500450857 0.112726139129603 0.738106749260289 GO:0019001 guanyl nucleotide binding 30/1109 400/18639 0.075 1.26052750225428 0.113840853470639 0.738106749260289 GO:0032561 guanyl ribonucleotide binding 30/1109 400/18639 0.075 1.26052750225428 0.113840853470639 0.738106749260289 GO:0004955 prostaglandin receptor activity 2/1109 10/18639 0.2 3.36140667267809 0.115901059801202 0.738106749260289 GO:0008140 cAMP response element binding protein binding 2/1109 10/18639 0.2 3.36140667267809 0.115901059801202 0.738106749260289 GO:0016303 1-phosphatidylinositol-3-kinase activity 2/1109 10/18639 0.2 3.36140667267809 0.115901059801202 0.738106749260289 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 2/1109 10/18639 0.2 3.36140667267809 0.115901059801202 0.738106749260289 GO:0032052 bile acid binding 2/1109 10/18639 0.2 3.36140667267809 0.115901059801202 0.738106749260289 GO:0141109 transporter activator activity 2/1109 10/18639 0.2 3.36140667267809 0.115901059801202 0.738106749260289 GO:0016790 thiolester hydrolase activity 5/1109 44/18639 0.113636363636364 1.90989015493073 0.118725519695883 0.742536056029949 GO:0030020 extracellular matrix structural constituent conferring tensile strength 5/1109 44/18639 0.113636363636364 1.90989015493073 0.118725519695883 0.742536056029949 GO:1902936 phosphatidylinositol bisphosphate binding 10/1109 111/18639 0.0900900900900901 1.51414714985499 0.124485300645293 0.742536056029949 GO:0005543 phospholipid binding 36/1109 497/18639 0.0724346076458753 1.21741086736832 0.128528749774838 0.742536056029949 GO:0005506 iron ion binding 13/1109 154/18639 0.0844155844155844 1.41877554366283 0.128754556973471 0.742536056029949 GO:0003713 transcription coactivator activity 20/1109 256/18639 0.078125 1.31304948151488 0.129664626311242 0.742536056029949 GO:0004713 protein tyrosine kinase activity 12/1109 140/18639 0.0857142857142857 1.44060285971918 0.129676541939983 0.742536056029949 GO:0005200 structural constituent of cytoskeleton 10/1109 112/18639 0.0892857142857143 1.50062797887415 0.129866547190853 0.742536056029949 GO:0004519 endonuclease activity 11/1109 127/18639 0.0866141732283465 1.4557272991913 0.135280151287605 0.742536056029949 GO:0004954 prostanoid receptor activity 2/1109 11/18639 0.181818181818182 3.05582424788917 0.136283191171461 0.742536056029949 GO:0005114 type II transforming growth factor beta receptor binding 2/1109 11/18639 0.181818181818182 3.05582424788917 0.136283191171461 0.742536056029949 GO:0005225 volume-sensitive anion channel activity 2/1109 11/18639 0.181818181818182 3.05582424788917 0.136283191171461 0.742536056029949 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 2/1109 11/18639 0.181818181818182 3.05582424788917 0.136283191171461 0.742536056029949 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 2/1109 11/18639 0.181818181818182 3.05582424788917 0.136283191171461 0.742536056029949 GO:0019206 nucleoside kinase activity 2/1109 11/18639 0.181818181818182 3.05582424788917 0.136283191171461 0.742536056029949 GO:0034056 estrogen response element binding 2/1109 11/18639 0.181818181818182 3.05582424788917 0.136283191171461 0.742536056029949 GO:0042608 T cell receptor binding 2/1109 11/18639 0.181818181818182 3.05582424788917 0.136283191171461 0.742536056029949 GO:0043522 leucine zipper domain binding 2/1109 11/18639 0.181818181818182 3.05582424788917 0.136283191171461 0.742536056029949 GO:0050786 RAGE receptor binding 2/1109 11/18639 0.181818181818182 3.05582424788917 0.136283191171461 0.742536056029949 GO:0097493 structural molecule activity conferring elasticity 2/1109 11/18639 0.181818181818182 3.05582424788917 0.136283191171461 0.742536056029949 GO:0140031 phosphorylation-dependent protein binding 2/1109 11/18639 0.181818181818182 3.05582424788917 0.136283191171461 0.742536056029949 GO:0032931 histone H3K56 acetyltransferase activity 3/1109 22/18639 0.136363636363636 2.29186818591688 0.139779514679651 0.742536056029949 GO:0043992 histone H3K9 acetyltransferase activity 3/1109 22/18639 0.136363636363636 2.29186818591688 0.139779514679651 0.742536056029949 GO:0043993 histone H3K18 acetyltransferase activity 3/1109 22/18639 0.136363636363636 2.29186818591688 0.139779514679651 0.742536056029949 GO:0043994 histone H3K23 acetyltransferase activity 3/1109 22/18639 0.136363636363636 2.29186818591688 0.139779514679651 0.742536056029949 GO:0043999 histone H2AK5 acetyltransferase activity 3/1109 22/18639 0.136363636363636 2.29186818591688 0.139779514679651 0.742536056029949 GO:0044012 histone H2AK9 acetyltransferase activity 3/1109 22/18639 0.136363636363636 2.29186818591688 0.139779514679651 0.742536056029949 GO:0044014 histone H2BK5 acetyltransferase activity 3/1109 22/18639 0.136363636363636 2.29186818591688 0.139779514679651 0.742536056029949 GO:0044015 histone H2BK12 acetyltransferase activity 3/1109 22/18639 0.136363636363636 2.29186818591688 0.139779514679651 0.742536056029949 GO:0044016 histone H3K4 acetyltransferase activity 3/1109 22/18639 0.136363636363636 2.29186818591688 0.139779514679651 0.742536056029949 GO:0044017 histone H3K27 acetyltransferase activity 3/1109 22/18639 0.136363636363636 2.29186818591688 0.139779514679651 0.742536056029949 GO:0044018 histone H3K36 acetyltransferase activity 3/1109 22/18639 0.136363636363636 2.29186818591688 0.139779514679651 0.742536056029949 GO:0046972 histone H4K16 acetyltransferase activity 3/1109 22/18639 0.136363636363636 2.29186818591688 0.139779514679651 0.742536056029949 GO:0140908 histone H3K122 acetyltransferase activity 3/1109 22/18639 0.136363636363636 2.29186818591688 0.139779514679651 0.742536056029949 GO:0043539 protein serine/threonine kinase activator activity 7/1109 73/18639 0.0958904109589041 1.61163333621552 0.142765230226122 0.754715221923526 GO:0019903 protein phosphatase binding 12/1109 144/18639 0.0833333333333333 1.40058611361587 0.149778273782839 0.766598500283045 GO:0016298 lipase activity 11/1109 130/18639 0.0846153846153846 1.42213359228688 0.151446586718457 0.766598500283045 GO:0016651 oxidoreductase activity, acting on NAD(P)H 8/1109 88/18639 0.0909090909090909 1.52791212394459 0.152391669919753 0.766598500283045 GO:0015294 solute:monoatomic cation symporter activity 10/1109 116/18639 0.0862068965517241 1.44888218649918 0.152606332455817 0.766598500283045 GO:0017134 fibroblast growth factor binding 3/1109 23/18639 0.130434782608696 2.19222174305093 0.154046680710438 0.766598500283045 GO:0044013 histone H2B acetyltransferase activity 3/1109 23/18639 0.130434782608696 2.19222174305093 0.154046680710438 0.766598500283045 GO:0140693 molecular condensate scaffold activity 5/1109 48/18639 0.104166666666667 1.75073264201984 0.155171005145317 0.766598500283045 GO:0141003 histone H2AX kinase activity 26/1109 354/18639 0.0734463276836158 1.23441487979704 0.156795608118086 0.766598500283045 GO:0005025 transforming growth factor beta receptor activity, type I 2/1109 12/18639 0.166666666666667 2.80117222723174 0.157371169274968 0.766598500283045 GO:0005026 transforming growth factor beta receptor activity, type II 2/1109 12/18639 0.166666666666667 2.80117222723174 0.157371169274968 0.766598500283045 GO:0005436 sodium:phosphate symporter activity 2/1109 12/18639 0.166666666666667 2.80117222723174 0.157371169274968 0.766598500283045 GO:0016361 activin receptor activity, type I 2/1109 12/18639 0.166666666666667 2.80117222723174 0.157371169274968 0.766598500283045 GO:0016362 activin receptor activity, type II 2/1109 12/18639 0.166666666666667 2.80117222723174 0.157371169274968 0.766598500283045 GO:0017002 activin receptor activity 2/1109 12/18639 0.166666666666667 2.80117222723174 0.157371169274968 0.766598500283045 GO:0017166 vinculin binding 2/1109 12/18639 0.166666666666667 2.80117222723174 0.157371169274968 0.766598500283045 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 2/1109 12/18639 0.166666666666667 2.80117222723174 0.157371169274968 0.766598500283045 GO:1990817 poly(A) RNA polymerase activity 2/1109 12/18639 0.166666666666667 2.80117222723174 0.157371169274968 0.766598500283045 GO:0003725 double-stranded RNA binding 7/1109 75/18639 0.0933333333333333 1.56865644724977 0.157684172693666 0.766598500283045 GO:1990782 protein tyrosine kinase binding 10/1109 117/18639 0.0854700854700855 1.43649857806756 0.158586150859723 0.76755697016106 GO:0000993 RNA polymerase II complex binding 4/1109 36/18639 0.111111111111111 1.86744815148783 0.163978674143525 0.790145027178313 GO:0140996 histone H3 kinase activity 26/1109 357/18639 0.0728291316526611 1.22404164551303 0.167084689232753 0.795508689479037 GO:0004622 lysophospholipase activity 3/1109 24/18639 0.125 2.10087917042381 0.16874426746525 0.795508689479037 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 3/1109 24/18639 0.125 2.10087917042381 0.16874426746525 0.795508689479037 GO:0043998 histone H2A acetyltransferase activity 3/1109 24/18639 0.125 2.10087917042381 0.16874426746525 0.795508689479037 GO:0060229 lipase activator activity 3/1109 24/18639 0.125 2.10087917042381 0.16874426746525 0.795508689479037 GO:0035173 histone kinase activity 26/1109 360/18639 0.0722222222222222 1.21384129846709 0.177736032484871 0.819079217200757 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 2/1109 13/18639 0.153846153846154 2.58569744052161 0.17900904838731 0.819079217200757 GO:0008035 high-density lipoprotein particle binding 2/1109 13/18639 0.153846153846154 2.58569744052161 0.17900904838731 0.819079217200757 GO:0045159 myosin II binding 2/1109 13/18639 0.153846153846154 2.58569744052161 0.17900904838731 0.819079217200757 GO:0061459 L-arginine transmembrane transporter activity 2/1109 13/18639 0.153846153846154 2.58569744052161 0.17900904838731 0.819079217200757 GO:0070123 transforming growth factor beta receptor activity, type III 2/1109 13/18639 0.153846153846154 2.58569744052161 0.17900904838731 0.819079217200757 GO:0140410 monoatomic cation:bicarbonate symporter activity 2/1109 13/18639 0.153846153846154 2.58569744052161 0.17900904838731 0.819079217200757 GO:0004518 nuclease activity 16/1109 209/18639 0.076555023923445 1.28666284121649 0.181198675936633 0.825629113368175 GO:0015296 monoatomic anion:monoatomic cation symporter activity 3/1109 25/18639 0.12 2.01684400360685 0.183825363149962 0.828259529743284 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 3/1109 25/18639 0.12 2.01684400360685 0.183825363149962 0.828259529743284 GO:0003924 GTPase activity 24/1109 331/18639 0.0725075528700906 1.21863686018541 0.184057673276285 0.828259529743284 GO:0002020 protease binding 11/1109 136/18639 0.0808823529411765 1.35939240439187 0.186559451801417 0.836062728443386 GO:0160215 deacylase activity 6/1109 65/18639 0.0923076923076923 1.55141846431296 0.188830002487703 0.842769970119298 GO:0005227 calcium-activated cation channel activity 3/1109 26/18639 0.115384615384615 1.9392730803912 0.199243855031244 0.862011720412591 GO:0008198 ferrous iron binding 3/1109 26/18639 0.115384615384615 1.9392730803912 0.199243855031244 0.862011720412591 GO:0003774 cytoskeletal motor activity 12/1109 153/18639 0.0784313725490196 1.31819869516788 0.200452016023596 0.862011720412591 GO:0005344 oxygen carrier activity 2/1109 14/18639 0.142857142857143 2.40100476619863 0.201056911831771 0.862011720412591 GO:0005545 1-phosphatidylinositol binding 2/1109 14/18639 0.142857142857143 2.40100476619863 0.201056911831771 0.862011720412591 GO:0030983 mismatched DNA binding 2/1109 14/18639 0.142857142857143 2.40100476619863 0.201056911831771 0.862011720412591 GO:0032036 myosin heavy chain binding 2/1109 14/18639 0.142857142857143 2.40100476619863 0.201056911831771 0.862011720412591 GO:0043176 amine binding 2/1109 14/18639 0.142857142857143 2.40100476619863 0.201056911831771 0.862011720412591 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 2/1109 14/18639 0.142857142857143 2.40100476619863 0.201056911831771 0.862011720412591 GO:0098821 BMP receptor activity 2/1109 14/18639 0.142857142857143 2.40100476619863 0.201056911831771 0.862011720412591 GO:0016860 intramolecular oxidoreductase activity 5/1109 53/18639 0.0943396226415094 1.58556918522551 0.206214751467887 0.87769649904392 GO:0030971 receptor tyrosine kinase binding 7/1109 81/18639 0.0864197530864197 1.45245967337942 0.206327184348249 0.87769649904392 GO:0030331 nuclear estrogen receptor binding 4/1109 40/18639 0.1 1.68070333633904 0.212849903809791 0.894955773161632 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 4/1109 40/18639 0.1 1.68070333633904 0.212849903809791 0.894955773161632 GO:0071949 FAD binding 4/1109 40/18639 0.1 1.68070333633904 0.212849903809791 0.894955773161632 GO:0023026 MHC class II protein complex binding 3/1109 27/18639 0.111111111111111 1.86744815148783 0.214954693270436 0.89687992709389 GO:0035255 ionotropic glutamate receptor binding 3/1109 27/18639 0.111111111111111 1.86744815148783 0.214954693270436 0.89687992709389 GO:0050661 NADP binding 5/1109 54/18639 0.0925925925925926 1.55620679290652 0.217030352639499 0.902084175665703 GO:0004953 icosanoid receptor activity 2/1109 15/18639 0.133333333333333 2.24093778178539 0.223389519391836 0.90891908648001 GO:0010181 FMN binding 2/1109 15/18639 0.133333333333333 2.24093778178539 0.223389519391836 0.90891908648001 GO:0031386 protein tag activity 2/1109 15/18639 0.133333333333333 2.24093778178539 0.223389519391836 0.90891908648001 GO:0050700 CARD domain binding 2/1109 15/18639 0.133333333333333 2.24093778178539 0.223389519391836 0.90891908648001 GO:0141047 molecular tag activity 2/1109 15/18639 0.133333333333333 2.24093778178539 0.223389519391836 0.90891908648001 GO:0001540 amyloid-beta binding 7/1109 83/18639 0.0843373493975904 1.41746064510522 0.223682566737046 0.90891908648001 GO:0008137 NADH dehydrogenase (ubiquinone) activity 4/1109 41/18639 0.0975609756097561 1.63971057203809 0.225653851028813 0.913520608811813 GO:0140030 modification-dependent protein binding 13/1109 173/18639 0.0751445086705202 1.26295626430102 0.230853503717172 0.921118919046073 GO:0036408 histone H3K14 acetyltransferase activity 3/1109 28/18639 0.107142857142857 1.80075357464898 0.230914109182349 0.921118919046073 GO:0046966 nuclear thyroid hormone receptor binding 3/1109 28/18639 0.107142857142857 1.80075357464898 0.230914109182349 0.921118919046073 GO:0051019 mitogen-activated protein kinase binding 3/1109 28/18639 0.107142857142857 1.80075357464898 0.230914109182349 0.921118919046073 GO:0004527 exonuclease activity 7/1109 84/18639 0.0833333333333333 1.40058611361587 0.232545888267585 0.92424259972044 GO:0008307 structural constituent of muscle 4/1109 42/18639 0.0952380952380952 1.60066984413242 0.238647830852332 0.926422153276081 GO:0019894 kinesin binding 4/1109 42/18639 0.0952380952380952 1.60066984413242 0.238647830852332 0.926422153276081 GO:0043175 RNA polymerase core enzyme binding 4/1109 42/18639 0.0952380952380952 1.60066984413242 0.238647830852332 0.926422153276081 GO:0019902 phosphatase binding 14/1109 190/18639 0.0736842105263158 1.23841298467087 0.241624564878901 0.926422153276081 GO:0001221 transcription coregulator binding 9/1109 115/18639 0.0782608695652174 1.31533304583056 0.245488517907418 0.926422153276081 GO:0017124 SH3 domain binding 9/1109 115/18639 0.0782608695652174 1.31533304583056 0.245488517907418 0.926422153276081 GO:0005024 transforming growth factor beta receptor activity 2/1109 16/18639 0.125 2.10087917042381 0.245895058709173 0.926422153276081 GO:0005324 long-chain fatty acid transmembrane transporter activity 2/1109 16/18639 0.125 2.10087917042381 0.245895058709173 0.926422153276081 GO:0008296 3'-5'-DNA exonuclease activity 2/1109 16/18639 0.125 2.10087917042381 0.245895058709173 0.926422153276081 GO:0030275 LRR domain binding 2/1109 16/18639 0.125 2.10087917042381 0.245895058709173 0.926422153276081 GO:0043023 ribosomal large subunit binding 2/1109 16/18639 0.125 2.10087917042381 0.245895058709173 0.926422153276081 GO:0070411 I-SMAD binding 2/1109 16/18639 0.125 2.10087917042381 0.245895058709173 0.926422153276081 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 3/1109 29/18639 0.103448275862069 1.73865862379901 0.247079793072903 0.926422153276081 GO:0010484 histone H3 acetyltransferase activity 3/1109 29/18639 0.103448275862069 1.73865862379901 0.247079793072903 0.926422153276081 GO:0043236 laminin binding 3/1109 29/18639 0.103448275862069 1.73865862379901 0.247079793072903 0.926422153276081 GO:0097472 cyclin-dependent protein kinase activity 3/1109 29/18639 0.103448275862069 1.73865862379901 0.247079793072903 0.926422153276081 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 7/1109 86/18639 0.0813953488372093 1.36801434353178 0.250610466978335 0.926422153276081 GO:0016209 antioxidant activity 7/1109 86/18639 0.0813953488372093 1.36801434353178 0.250610466978335 0.926422153276081 GO:0004866 endopeptidase inhibitor activity 12/1109 161/18639 0.0745341614906832 1.25269813888624 0.251010547533279 0.926422153276081 GO:0004712 protein serine/threonine/tyrosine kinase activity 4/1109 43/18639 0.0930232558139535 1.56344496403632 0.251809878209109 0.926422153276081 GO:0008200 ion channel inhibitor activity 4/1109 43/18639 0.0930232558139535 1.56344496403632 0.251809878209109 0.926422153276081 GO:0048156 tau protein binding 4/1109 43/18639 0.0930232558139535 1.56344496403632 0.251809878209109 0.926422153276081 GO:0022839 monoatomic ion-gated channel activity 3/1109 30/18639 0.1 1.68070333633904 0.263411036318844 0.928152947568267 GO:0043995 histone H4K5 acetyltransferase activity 3/1109 30/18639 0.1 1.68070333633904 0.263411036318844 0.928152947568267 GO:0043996 histone H4K8 acetyltransferase activity 3/1109 30/18639 0.1 1.68070333633904 0.263411036318844 0.928152947568267 GO:0043997 histone H4K12 acetyltransferase activity 3/1109 30/18639 0.1 1.68070333633904 0.263411036318844 0.928152947568267 GO:0070566 adenylyltransferase activity 3/1109 30/18639 0.1 1.68070333633904 0.263411036318844 0.928152947568267 GO:0001223 transcription coactivator binding 4/1109 44/18639 0.0909090909090909 1.52791212394459 0.265118314060432 0.928152947568267 GO:0003954 NADH dehydrogenase activity 4/1109 44/18639 0.0909090909090909 1.52791212394459 0.265118314060432 0.928152947568267 GO:0016248 channel inhibitor activity 4/1109 44/18639 0.0909090909090909 1.52791212394459 0.265118314060432 0.928152947568267 GO:0043014 alpha-tubulin binding 4/1109 44/18639 0.0909090909090909 1.52791212394459 0.265118314060432 0.928152947568267 GO:0004521 RNA endonuclease activity 6/1109 73/18639 0.0821917808219178 1.38140000247045 0.266858403712694 0.928152947568267 GO:0004659 prenyltransferase activity 2/1109 17/18639 0.117647058823529 1.97729804275182 0.268473993098259 0.928152947568267 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 2/1109 17/18639 0.117647058823529 1.97729804275182 0.268473993098259 0.928152947568267 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 2/1109 17/18639 0.117647058823529 1.97729804275182 0.268473993098259 0.928152947568267 GO:0030169 low-density lipoprotein particle binding 2/1109 17/18639 0.117647058823529 1.97729804275182 0.268473993098259 0.928152947568267 GO:0032183 SUMO binding 2/1109 17/18639 0.117647058823529 1.97729804275182 0.268473993098259 0.928152947568267 GO:0045125 bioactive lipid receptor activity 2/1109 17/18639 0.117647058823529 1.97729804275182 0.268473993098259 0.928152947568267 GO:0051787 misfolded protein binding 2/1109 17/18639 0.117647058823529 1.97729804275182 0.268473993098259 0.928152947568267 GO:0070402 NADPH binding 2/1109 17/18639 0.117647058823529 1.97729804275182 0.268473993098259 0.928152947568267 GO:1990226 histone methyltransferase binding 2/1109 17/18639 0.117647058823529 1.97729804275182 0.268473993098259 0.928152947568267 GO:0031593 polyubiquitin modification-dependent protein binding 5/1109 59/18639 0.0847457627118644 1.42432486130427 0.273407852148839 0.929304854878186 GO:0070063 RNA polymerase binding 5/1109 59/18639 0.0847457627118644 1.42432486130427 0.273407852148839 0.929304854878186 GO:0008509 monoatomic anion transmembrane transporter activity 11/1109 149/18639 0.0738255033557047 1.24078769796842 0.273436341459054 0.929304854878186 GO:0048029 monosaccharide binding 6/1109 74/18639 0.0810810810810811 1.3627324348695 0.277157301232176 0.929304854878186 GO:0051539 4 iron, 4 sulfur cluster binding 4/1109 45/18639 0.0888888888888889 1.49395852119026 0.278551822797692 0.929304854878186 GO:0140303 intramembrane lipid transporter activity 4/1109 45/18639 0.0888888888888889 1.49395852119026 0.278551822797692 0.929304854878186 GO:0141110 transporter inhibitor activity 4/1109 45/18639 0.0888888888888889 1.49395852119026 0.278551822797692 0.929304854878186 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 13/1109 181/18639 0.0718232044198895 1.20713499295069 0.281525154782418 0.929304854878186 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 5/1109 60/18639 0.0833333333333333 1.40058611361587 0.285048422537372 0.929304854878186 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 2/1109 18/18639 0.111111111111111 1.86744815148783 0.291037998740184 0.929304854878186 GO:0008409 5'-3' exonuclease activity 2/1109 18/18639 0.111111111111111 1.86744815148783 0.291037998740184 0.929304854878186 GO:0015280 ligand-gated sodium channel activity 2/1109 18/18639 0.111111111111111 1.86744815148783 0.291037998740184 0.929304854878186 GO:0017075 syntaxin-1 binding 2/1109 18/18639 0.111111111111111 1.86744815148783 0.291037998740184 0.929304854878186 GO:0034185 apolipoprotein binding 2/1109 18/18639 0.111111111111111 1.86744815148783 0.291037998740184 0.929304854878186 GO:0050811 GABA receptor binding 2/1109 18/18639 0.111111111111111 1.86744815148783 0.291037998740184 0.929304854878186 GO:0070064 proline-rich region binding 2/1109 18/18639 0.111111111111111 1.86744815148783 0.291037998740184 0.929304854878186 GO:1990381 ubiquitin-specific protease binding 2/1109 18/18639 0.111111111111111 1.86744815148783 0.291037998740184 0.929304854878186 GO:0004180 carboxypeptidase activity 4/1109 46/18639 0.0869565217391304 1.46148116203395 0.292089521266435 0.929304854878186 GO:0015106 bicarbonate transmembrane transporter activity 3/1109 32/18639 0.09375 1.57565937781785 0.296416007221144 0.929304854878186 GO:0031369 translation initiation factor binding 3/1109 32/18639 0.09375 1.57565937781785 0.296416007221144 0.929304854878186 GO:0043425 bHLH transcription factor binding 3/1109 32/18639 0.09375 1.57565937781785 0.296416007221144 0.929304854878186 GO:0071813 lipoprotein particle binding 3/1109 32/18639 0.09375 1.57565937781785 0.296416007221144 0.929304854878186 GO:0071814 protein-lipid complex binding 3/1109 32/18639 0.09375 1.57565937781785 0.296416007221144 0.929304854878186 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 5/1109 61/18639 0.0819672131147541 1.37762568552381 0.296779349594395 0.929304854878186 GO:0019905 syntaxin binding 5/1109 61/18639 0.0819672131147541 1.37762568552381 0.296779349594395 0.929304854878186 GO:0008237 metallopeptidase activity 13/1109 184/18639 0.0706521739130435 1.18745344415259 0.301384644982872 0.929304854878186 GO:0061135 endopeptidase regulator activity 13/1109 184/18639 0.0706521739130435 1.18745344415259 0.301384644982872 0.929304854878186 GO:0030414 peptidase inhibitor activity 12/1109 169/18639 0.0710059171597633 1.19339881870228 0.305593406512199 0.929304854878186 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 3/1109 33/18639 0.0909090909090909 1.52791212394459 0.313017182561281 0.929304854878186 GO:0071889 14-3-3 protein binding 3/1109 33/18639 0.0909090909090909 1.52791212394459 0.313017182561281 0.929304854878186 GO:0015245 fatty acid transmembrane transporter activity 2/1109 19/18639 0.105263157894737 1.76916140667268 0.313508984713099 0.929304854878186 GO:0042577 lipid phosphatase activity 2/1109 19/18639 0.105263157894737 1.76916140667268 0.313508984713099 0.929304854878186 GO:0046624 sphingolipid transporter activity 2/1109 19/18639 0.105263157894737 1.76916140667268 0.313508984713099 0.929304854878186 GO:0005125 cytokine activity 16/1109 234/18639 0.0683760683760684 1.14919886245405 0.31896084616842 0.929304854878186 GO:0140375 immune receptor activity 11/1109 156/18639 0.0705128205128205 1.18511132690574 0.324730956163136 0.929304854878186 GO:0008201 heparin binding 12/1109 172/18639 0.0697674418604651 1.17258372302724 0.326837210178338 0.929304854878186 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 3/1109 34/18639 0.0882352941176471 1.48297353206386 0.329638908398817 0.929304854878186 GO:0016831 carboxy-lyase activity 3/1109 34/18639 0.0882352941176471 1.48297353206386 0.329638908398817 0.929304854878186 GO:0001222 transcription corepressor binding 4/1109 49/18639 0.0816326530612245 1.37200272354208 0.333126639392538 0.929304854878186 GO:0015464 acetylcholine receptor activity 2/1109 20/18639 0.1 1.68070333633904 0.335818189777931 0.929304854878186 GO:0016004 phospholipase activator activity 2/1109 20/18639 0.1 1.68070333633904 0.335818189777931 0.929304854878186 GO:0016505 peptidase activator activity involved in apoptotic process 2/1109 20/18639 0.1 1.68070333633904 0.335818189777931 0.929304854878186 GO:0000049 tRNA binding 6/1109 80/18639 0.075 1.26052750225428 0.340516545791429 0.929304854878186 GO:0120013 lipid transfer activity 5/1109 65/18639 0.0769230769230769 1.2928487202608 0.34434642309623 0.929304854878186 GO:0016407 acetyltransferase activity 7/1109 96/18639 0.0729166666666667 1.22551284941389 0.345898362722928 0.929304854878186 GO:0010485 histone H4 acetyltransferase activity 3/1109 35/18639 0.0857142857142857 1.44060285971918 0.346249634236386 0.929304854878186 GO:0004674 protein serine/threonine kinase activity 28/1109 433/18639 0.0646651270207852 1.08682894728622 0.351226386898287 0.929304854878186 GO:0015101 organic cation transmembrane transporter activity 6/1109 81/18639 0.0740740740740741 1.24496543432522 0.351251694706884 0.929304854878186 GO:0140097 catalytic activity, acting on DNA 22/1109 336/18639 0.0654761904761905 1.10046051784104 0.35206170822875 0.929304854878186 GO:0015631 tubulin binding 25/1109 385/18639 0.0649350649350649 1.09136580281756 0.354351317270413 0.929304854878186 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 2/1109 21/18639 0.0952380952380952 1.60066984413242 0.357905350267377 0.929304854878186 GO:0005248 voltage-gated sodium channel activity 2/1109 21/18639 0.0952380952380952 1.60066984413242 0.357905350267377 0.929304854878186 GO:0015174 basic amino acid transmembrane transporter activity 2/1109 21/18639 0.0952380952380952 1.60066984413242 0.357905350267377 0.929304854878186 GO:0019200 carbohydrate kinase activity 2/1109 21/18639 0.0952380952380952 1.60066984413242 0.357905350267377 0.929304854878186 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 2/1109 21/18639 0.0952380952380952 1.60066984413242 0.357905350267377 0.929304854878186 GO:0140312 cargo adaptor activity 2/1109 21/18639 0.0952380952380952 1.60066984413242 0.357905350267377 0.929304854878186 GO:0005272 sodium channel activity 4/1109 51/18639 0.0784313725490196 1.31819869516788 0.36064728918753 0.929304854878186 GO:0016830 carbon-carbon lyase activity 4/1109 51/18639 0.0784313725490196 1.31819869516788 0.36064728918753 0.929304854878186 GO:0044390 ubiquitin-like protein conjugating enzyme binding 3/1109 36/18639 0.0833333333333333 1.40058611361587 0.362819721517555 0.929304854878186 GO:0050840 extracellular matrix binding 5/1109 67/18639 0.0746268656716418 1.25425622114854 0.368340446609725 0.929304854878186 GO:0061134 peptidase regulator activity 15/1109 226/18639 0.0663716814159292 1.11551106394184 0.368896715522225 0.929304854878186 GO:0015293 symporter activity 10/1109 146/18639 0.0684931506849315 1.15116666872537 0.369887946434716 0.929304854878186 GO:0005080 protein kinase C binding 4/1109 52/18639 0.0769230769230769 1.2928487202608 0.374402566808158 0.929304854878186 GO:0008093 cytoskeletal anchor activity 2/1109 22/18639 0.0909090909090909 1.52791212394459 0.37971793382615 0.929304854878186 GO:0008970 phospholipase A1 activity 2/1109 22/18639 0.0909090909090909 1.52791212394459 0.37971793382615 0.929304854878186 GO:0015377 chloride:monoatomic cation symporter activity 2/1109 22/18639 0.0909090909090909 1.52791212394459 0.37971793382615 0.929304854878186 GO:0033691 sialic acid binding 2/1109 22/18639 0.0909090909090909 1.52791212394459 0.37971793382615 0.929304854878186 GO:0003777 microtubule motor activity 5/1109 68/18639 0.0735294117647059 1.23581127671989 0.380348175631835 0.929304854878186 GO:0005548 phospholipid transporter activity 5/1109 68/18639 0.0735294117647059 1.23581127671989 0.380348175631835 0.929304854878186 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 5/1109 68/18639 0.0735294117647059 1.23581127671989 0.380348175631835 0.929304854878186 GO:0051117 ATPase binding 6/1109 84/18639 0.0714285714285714 1.20050238309932 0.383580249758284 0.929304854878186 GO:0009055 electron transfer activity 8/1109 116/18639 0.0689655172413793 1.15910574919934 0.386089704377643 0.929304854878186 GO:0005544 calcium-dependent phospholipid binding 4/1109 53/18639 0.0754716981132075 1.26845534818041 0.388132184386956 0.929304854878186 GO:0038064 collagen receptor activity 4/1109 53/18639 0.0754716981132075 1.26845534818041 0.388132184386956 0.929304854878186 GO:0140296 general transcription initiation factor binding 4/1109 53/18639 0.0754716981132075 1.26845534818041 0.388132184386956 0.929304854878186 GO:0042887 amide transmembrane transporter activity 3/1109 38/18639 0.0789473684210526 1.32687105500451 0.395728909507393 0.929304854878186 GO:0106310 protein serine kinase activity 23/1109 361/18639 0.0637119113573407 1.0708082198282 0.397688947829255 0.929304854878186 GO:0016493 C-C chemokine receptor activity 2/1109 23/18639 0.0869565217391304 1.46148116203395 0.401210434122885 0.929304854878186 GO:0042171 lysophosphatidic acid acyltransferase activity 2/1109 23/18639 0.0869565217391304 1.46148116203395 0.401210434122885 0.929304854878186 GO:0071617 lysophospholipid acyltransferase activity 2/1109 23/18639 0.0869565217391304 1.46148116203395 0.401210434122885 0.929304854878186 GO:0015485 cholesterol binding 4/1109 54/18639 0.0740740740740741 1.24496543432522 0.401820330926753 0.929304854878186 GO:0017069 snRNA binding 4/1109 54/18639 0.0740740740740741 1.24496543432522 0.401820330926753 0.929304854878186 GO:0030246 carbohydrate binding 18/1109 280/18639 0.0642857142857143 1.08045214478939 0.401898513122287 0.929304854878186 GO:0097110 scaffold protein binding 5/1109 70/18639 0.0714285714285714 1.20050238309932 0.404328862625685 0.929304854878186 GO:0008238 exopeptidase activity 7/1109 102/18639 0.0686274509803922 1.15342385827189 0.40505936828225 0.929304854878186 GO:0050660 flavin adenine dinucleotide binding 6/1109 86/18639 0.0697674418604651 1.17258372302724 0.405151237930891 0.929304854878186 GO:0016829 lyase activity 13/1109 200/18639 0.065 1.09245716862038 0.412078572807683 0.929304854878186 GO:0016247 channel regulator activity 11/1109 168/18639 0.0654761904761905 1.10046051784104 0.416343082772171 0.929304854878186 GO:0019838 growth factor binding 9/1109 136/18639 0.0661764705882353 1.1122301490479 0.42064387068331 0.929304854878186 GO:0004806 triacylglycerol lipase activity 2/1109 24/18639 0.0833333333333333 1.40058611361587 0.422343722000851 0.929304854878186 GO:0005315 phosphate transmembrane transporter activity 2/1109 24/18639 0.0833333333333333 1.40058611361587 0.422343722000851 0.929304854878186 GO:0005540 hyaluronic acid binding 2/1109 24/18639 0.0833333333333333 1.40058611361587 0.422343722000851 0.929304854878186 GO:0015295 solute:proton symporter activity 2/1109 24/18639 0.0833333333333333 1.40058611361587 0.422343722000851 0.929304854878186 GO:0019957 C-C chemokine binding 2/1109 24/18639 0.0833333333333333 1.40058611361587 0.422343722000851 0.929304854878186 GO:0050431 transforming growth factor beta binding 2/1109 24/18639 0.0833333333333333 1.40058611361587 0.422343722000851 0.929304854878186 GO:0030170 pyridoxal phosphate binding 4/1109 56/18639 0.0714285714285714 1.20050238309932 0.429012692617806 0.929304854878186 GO:0141108 transporter regulator activity 11/1109 170/18639 0.0647058823529412 1.0875139235135 0.431761660578861 0.929304854878186 GO:0031406 carboxylic acid binding 12/1109 187/18639 0.0641711229946524 1.07852620513735 0.436279259223461 0.929304854878186 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 8/1109 122/18639 0.0655737704918033 1.10210054841905 0.441048011985823 0.929304854878186 GO:0070279 vitamin B6 binding 4/1109 57/18639 0.0701754385964912 1.17944093778179 0.442489030447194 0.929304854878186 GO:0017025 TBP-class protein binding 2/1109 25/18639 0.08 1.34456266907124 0.443084448857451 0.929304854878186 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 2/1109 25/18639 0.08 1.34456266907124 0.443084448857451 0.929304854878186 GO:0120020 cholesterol transfer activity 2/1109 25/18639 0.08 1.34456266907124 0.443084448857451 0.929304854878186 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 3/1109 41/18639 0.0731707317073171 1.22978292902857 0.444154788422845 0.929304854878186 GO:0140767 enzyme-substrate adaptor activity 9/1109 139/18639 0.0647482014388489 1.08822518180226 0.446373500113843 0.929304854878186 GO:0043177 organic acid binding 12/1109 189/18639 0.0634920634920635 1.06711322942162 0.450977938113473 0.929304854878186 GO:0003684 damaged DNA binding 5/1109 74/18639 0.0675675675675676 1.13561036239125 0.451859461858944 0.929304854878186 GO:0035064 methylated histone binding 5/1109 74/18639 0.0675675675675676 1.13561036239125 0.451859461858944 0.929304854878186 GO:0008408 3'-5' exonuclease activity 4/1109 58/18639 0.0689655172413793 1.15910574919934 0.45586814634382 0.929304854878186 GO:0004090 carbonyl reductase (NADPH) activity 1/1109 10/18639 0.1 1.68070333633904 0.458589440032744 0.929304854878186 GO:0004382 GDP phosphatase activity 1/1109 10/18639 0.1 1.68070333633904 0.458589440032744 0.929304854878186 GO:0005031 tumor necrosis factor receptor activity 1/1109 10/18639 0.1 1.68070333633904 0.458589440032744 0.929304854878186 GO:0005131 growth hormone receptor binding 1/1109 10/18639 0.1 1.68070333633904 0.458589440032744 0.929304854878186 GO:0005381 iron ion transmembrane transporter activity 1/1109 10/18639 0.1 1.68070333633904 0.458589440032744 0.929304854878186 GO:0005522 profilin binding 1/1109 10/18639 0.1 1.68070333633904 0.458589440032744 0.929304854878186 GO:0008190 eukaryotic initiation factor 4E binding 1/1109 10/18639 0.1 1.68070333633904 0.458589440032744 0.929304854878186 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 1/1109 10/18639 0.1 1.68070333633904 0.458589440032744 0.929304854878186 GO:0008401 retinoic acid 4-hydroxylase activity 1/1109 10/18639 0.1 1.68070333633904 0.458589440032744 0.929304854878186 GO:0015187 glycine transmembrane transporter activity 1/1109 10/18639 0.1 1.68070333633904 0.458589440032744 0.929304854878186 GO:0015279 store-operated calcium channel activity 1/1109 10/18639 0.1 1.68070333633904 0.458589440032744 0.929304854878186 GO:0016175 superoxide-generating NAD(P)H oxidase activity 1/1109 10/18639 0.1 1.68070333633904 0.458589440032744 0.929304854878186 GO:0016427 tRNA (cytidine) methyltransferase activity 1/1109 10/18639 0.1 1.68070333633904 0.458589440032744 0.929304854878186 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 1/1109 10/18639 0.1 1.68070333633904 0.458589440032744 0.929304854878186 GO:0016783 sulfurtransferase activity 1/1109 10/18639 0.1 1.68070333633904 0.458589440032744 0.929304854878186 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 1/1109 10/18639 0.1 1.68070333633904 0.458589440032744 0.929304854878186 GO:0016889 DNA endonuclease activity, producing 3'-phosphomonoesters 1/1109 10/18639 0.1 1.68070333633904 0.458589440032744 0.929304854878186 GO:0019531 oxalate transmembrane transporter activity 1/1109 10/18639 0.1 1.68070333633904 0.458589440032744 0.929304854878186 GO:0030957 Tat protein binding 1/1109 10/18639 0.1 1.68070333633904 0.458589440032744 0.929304854878186 GO:0031434 mitogen-activated protein kinase kinase binding 1/1109 10/18639 0.1 1.68070333633904 0.458589440032744 0.929304854878186 GO:0031720 haptoglobin binding 1/1109 10/18639 0.1 1.68070333633904 0.458589440032744 0.929304854878186 GO:0031957 very long-chain fatty acid-CoA ligase activity 1/1109 10/18639 0.1 1.68070333633904 0.458589440032744 0.929304854878186 GO:0032356 oxidized DNA binding 1/1109 10/18639 0.1 1.68070333633904 0.458589440032744 0.929304854878186 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 1/1109 10/18639 0.1 1.68070333633904 0.458589440032744 0.929304854878186 GO:0035256 G protein-coupled glutamate receptor binding 1/1109 10/18639 0.1 1.68070333633904 0.458589440032744 0.929304854878186 GO:0035374 chondroitin sulfate binding 1/1109 10/18639 0.1 1.68070333633904 0.458589440032744 0.929304854878186 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 1/1109 10/18639 0.1 1.68070333633904 0.458589440032744 0.929304854878186 GO:0042166 acetylcholine binding 1/1109 10/18639 0.1 1.68070333633904 0.458589440032744 0.929304854878186 GO:0043121 neurotrophin binding 1/1109 10/18639 0.1 1.68070333633904 0.458589440032744 0.929304854878186 GO:0043295 glutathione binding 1/1109 10/18639 0.1 1.68070333633904 0.458589440032744 0.929304854878186 GO:0047429 nucleoside triphosphate diphosphatase activity 1/1109 10/18639 0.1 1.68070333633904 0.458589440032744 0.929304854878186 GO:0050308 sugar-phosphatase activity 1/1109 10/18639 0.1 1.68070333633904 0.458589440032744 0.929304854878186 GO:0051864 histone H3K36 demethylase activity 1/1109 10/18639 0.1 1.68070333633904 0.458589440032744 0.929304854878186 GO:0051880 G-quadruplex DNA binding 1/1109 10/18639 0.1 1.68070333633904 0.458589440032744 0.929304854878186 GO:0070513 death domain binding 1/1109 10/18639 0.1 1.68070333633904 0.458589440032744 0.929304854878186 GO:0070739 protein-glutamic acid ligase activity 1/1109 10/18639 0.1 1.68070333633904 0.458589440032744 0.929304854878186 GO:0070740 tubulin-glutamic acid ligase activity 1/1109 10/18639 0.1 1.68070333633904 0.458589440032744 0.929304854878186 GO:0097177 mitochondrial ribosome binding 1/1109 10/18639 0.1 1.68070333633904 0.458589440032744 0.929304854878186 GO:0098505 G-rich strand telomeric DNA binding 1/1109 10/18639 0.1 1.68070333633904 0.458589440032744 0.929304854878186 GO:1905394 retromer complex binding 1/1109 10/18639 0.1 1.68070333633904 0.458589440032744 0.929304854878186 GO:1990757 ubiquitin ligase activator activity 1/1109 10/18639 0.1 1.68070333633904 0.458589440032744 0.929304854878186 GO:0004402 histone acetyltransferase activity 3/1109 42/18639 0.0714285714285714 1.20050238309932 0.459963015928269 0.929304854878186 GO:0005516 calmodulin binding 13/1109 207/18639 0.0628019323671498 1.05551417258008 0.461411463189499 0.929304854878186 GO:0001637 G protein-coupled chemoattractant receptor activity 2/1109 26/18639 0.0769230769230769 1.2928487202608 0.463404498342968 0.929304854878186 GO:0004950 chemokine receptor activity 2/1109 26/18639 0.0769230769230769 1.2928487202608 0.463404498342968 0.929304854878186 GO:0005160 transforming growth factor beta receptor binding 2/1109 26/18639 0.0769230769230769 1.2928487202608 0.463404498342968 0.929304854878186 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 2/1109 26/18639 0.0769230769230769 1.2928487202608 0.463404498342968 0.929304854878186 GO:0008157 protein phosphatase 1 binding 2/1109 26/18639 0.0769230769230769 1.2928487202608 0.463404498342968 0.929304854878186 GO:0019865 immunoglobulin binding 2/1109 26/18639 0.0769230769230769 1.2928487202608 0.463404498342968 0.929304854878186 GO:0030507 spectrin binding 2/1109 26/18639 0.0769230769230769 1.2928487202608 0.463404498342968 0.929304854878186 GO:0034237 protein kinase A regulatory subunit binding 2/1109 26/18639 0.0769230769230769 1.2928487202608 0.463404498342968 0.929304854878186 GO:0050681 nuclear androgen receptor binding 2/1109 26/18639 0.0769230769230769 1.2928487202608 0.463404498342968 0.929304854878186 GO:0070412 R-SMAD binding 2/1109 26/18639 0.0769230769230769 1.2928487202608 0.463404498342968 0.929304854878186 GO:0097602 cullin family protein binding 2/1109 26/18639 0.0769230769230769 1.2928487202608 0.463404498342968 0.929304854878186 GO:0005496 steroid binding 7/1109 108/18639 0.0648148148148148 1.08934475503457 0.463998164495351 0.929304854878186 GO:0043178 alcohol binding 6/1109 92/18639 0.0652173913043478 1.09611087152546 0.469268081315818 0.929304854878186 GO:0052689 carboxylic ester hydrolase activity 6/1109 92/18639 0.0652173913043478 1.09611087152546 0.469268081315818 0.929304854878186 GO:0051536 iron-sulfur cluster binding 5/1109 76/18639 0.0657894736842105 1.10572587917042 0.475256694218746 0.929304854878186 GO:0140034 methylation-dependent protein binding 5/1109 76/18639 0.0657894736842105 1.10572587917042 0.475256694218746 0.929304854878186 GO:0008375 acetylglucosaminyltransferase activity 3/1109 43/18639 0.0697674418604651 1.17258372302724 0.475574501257206 0.929304854878186 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 15/1109 243/18639 0.0617283950617284 1.03747119527101 0.479764509368751 0.929304854878186 GO:0001098 basal transcription machinery binding 4/1109 60/18639 0.0666666666666667 1.1204688908927 0.482287240449085 0.929304854878186 GO:0001099 basal RNA polymerase II transcription machinery binding 4/1109 60/18639 0.0666666666666667 1.1204688908927 0.482287240449085 0.929304854878186 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 4/1109 60/18639 0.0666666666666667 1.1204688908927 0.482287240449085 0.929304854878186 GO:0099106 ion channel regulator activity 10/1109 160/18639 0.0625 1.0504395852119 0.483078209499407 0.929304854878186 GO:0004364 glutathione transferase activity 2/1109 27/18639 0.0740740740740741 1.24496543432522 0.48328048274877 0.929304854878186 GO:0004683 calcium/calmodulin-dependent protein kinase activity 2/1109 27/18639 0.0740740740740741 1.24496543432522 0.48328048274877 0.929304854878186 GO:0005385 zinc ion transmembrane transporter activity 2/1109 27/18639 0.0740740740740741 1.24496543432522 0.48328048274877 0.929304854878186 GO:0008320 protein transmembrane transporter activity 2/1109 27/18639 0.0740740740740741 1.24496543432522 0.48328048274877 0.929304854878186 GO:0015252 proton channel activity 2/1109 27/18639 0.0740740740740741 1.24496543432522 0.48328048274877 0.929304854878186 GO:0003724 RNA helicase activity 5/1109 77/18639 0.0649350649350649 1.09136580281756 0.486833061302347 0.929304854878186 GO:0051540 metal cluster binding 5/1109 77/18639 0.0649350649350649 1.09136580281756 0.486833061302347 0.929304854878186 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 1/1109 11/18639 0.0909090909090909 1.52791212394459 0.490820064918873 0.929304854878186 GO:0002162 dystroglycan binding 1/1109 11/18639 0.0909090909090909 1.52791212394459 0.490820064918873 0.929304854878186 GO:0004523 RNA-DNA hybrid ribonuclease activity 1/1109 11/18639 0.0909090909090909 1.52791212394459 0.490820064918873 0.929304854878186 GO:0005536 D-glucose binding 1/1109 11/18639 0.0909090909090909 1.52791212394459 0.490820064918873 0.929304854878186 GO:0008199 ferric iron binding 1/1109 11/18639 0.0909090909090909 1.52791212394459 0.490820064918873 0.929304854878186 GO:0008271 secondary active sulfate transmembrane transporter activity 1/1109 11/18639 0.0909090909090909 1.52791212394459 0.490820064918873 0.929304854878186 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 1/1109 11/18639 0.0909090909090909 1.52791212394459 0.490820064918873 0.929304854878186 GO:0019203 carbohydrate phosphatase activity 1/1109 11/18639 0.0909090909090909 1.52791212394459 0.490820064918873 0.929304854878186 GO:0019215 intermediate filament binding 1/1109 11/18639 0.0909090909090909 1.52791212394459 0.490820064918873 0.929304854878186 GO:0019864 IgG binding 1/1109 11/18639 0.0909090909090909 1.52791212394459 0.490820064918873 0.929304854878186 GO:0031731 CCR6 chemokine receptor binding 1/1109 11/18639 0.0909090909090909 1.52791212394459 0.490820064918873 0.929304854878186 GO:0032050 clathrin heavy chain binding 1/1109 11/18639 0.0909090909090909 1.52791212394459 0.490820064918873 0.929304854878186 GO:0045294 alpha-catenin binding 1/1109 11/18639 0.0909090909090909 1.52791212394459 0.490820064918873 0.929304854878186 GO:0047676 arachidonate-CoA ligase activity 1/1109 11/18639 0.0909090909090909 1.52791212394459 0.490820064918873 0.929304854878186 GO:0048185 activin binding 1/1109 11/18639 0.0909090909090909 1.52791212394459 0.490820064918873 0.929304854878186 GO:0048407 platelet-derived growth factor binding 1/1109 11/18639 0.0909090909090909 1.52791212394459 0.490820064918873 0.929304854878186 GO:0070990 snRNP binding 1/1109 11/18639 0.0909090909090909 1.52791212394459 0.490820064918873 0.929304854878186 GO:0099528 G protein-coupled neurotransmitter receptor activity 1/1109 11/18639 0.0909090909090909 1.52791212394459 0.490820064918873 0.929304854878186 GO:0140537 transcription regulator activator activity 1/1109 11/18639 0.0909090909090909 1.52791212394459 0.490820064918873 0.929304854878186 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 1/1109 11/18639 0.0909090909090909 1.52791212394459 0.490820064918873 0.929304854878186 GO:1900750 oligopeptide binding 1/1109 11/18639 0.0909090909090909 1.52791212394459 0.490820064918873 0.929304854878186 GO:0005178 integrin binding 10/1109 161/18639 0.062111801242236 1.04391511573854 0.491059845227424 0.929304854878186 GO:0004676 3-phosphoinositide-dependent protein kinase activity 15/1109 245/18639 0.0612244897959184 1.02900204265656 0.492727591440274 0.929304854878186 GO:0004711 ribosomal protein S6 kinase activity 15/1109 245/18639 0.0612244897959184 1.02900204265656 0.492727591440274 0.929304854878186 GO:0035175 histone H3S10 kinase activity 15/1109 245/18639 0.0612244897959184 1.02900204265656 0.492727591440274 0.929304854878186 GO:0035979 histone H2AXS139 kinase activity 15/1109 245/18639 0.0612244897959184 1.02900204265656 0.492727591440274 0.929304854878186 GO:0044022 histone H3S28 kinase activity 15/1109 245/18639 0.0612244897959184 1.02900204265656 0.492727591440274 0.929304854878186 GO:0044023 histone H4S1 kinase activity 15/1109 245/18639 0.0612244897959184 1.02900204265656 0.492727591440274 0.929304854878186 GO:0044024 histone H2AS1 kinase activity 15/1109 245/18639 0.0612244897959184 1.02900204265656 0.492727591440274 0.929304854878186 GO:0044025 histone H2BS14 kinase activity 15/1109 245/18639 0.0612244897959184 1.02900204265656 0.492727591440274 0.929304854878186 GO:0072354 histone H3T3 kinase activity 15/1109 245/18639 0.0612244897959184 1.02900204265656 0.492727591440274 0.929304854878186 GO:0072371 histone H2AS121 kinase activity 15/1109 245/18639 0.0612244897959184 1.02900204265656 0.492727591440274 0.929304854878186 GO:0072518 Rho-dependent protein serine/threonine kinase activity 15/1109 245/18639 0.0612244897959184 1.02900204265656 0.492727591440274 0.929304854878186 GO:0140823 histone H2BS36 kinase activity 15/1109 245/18639 0.0612244897959184 1.02900204265656 0.492727591440274 0.929304854878186 GO:0140855 histone H3S57 kinase activity 15/1109 245/18639 0.0612244897959184 1.02900204265656 0.492727591440274 0.929304854878186 GO:0140995 histone H2A kinase activity 15/1109 245/18639 0.0612244897959184 1.02900204265656 0.492727591440274 0.929304854878186 GO:0140997 histone H4 kinase activity 15/1109 245/18639 0.0612244897959184 1.02900204265656 0.492727591440274 0.929304854878186 GO:0140998 histone H2B kinase activity 15/1109 245/18639 0.0612244897959184 1.02900204265656 0.492727591440274 0.929304854878186 GO:1990244 histone H2AT120 kinase activity 15/1109 245/18639 0.0612244897959184 1.02900204265656 0.492727591440274 0.929304854878186 GO:0005319 lipid transporter activity 11/1109 178/18639 0.0617977528089888 1.03863689324323 0.493009376874901 0.929304854878186 GO:0031490 chromatin DNA binding 8/1109 128/18639 0.0625 1.0504395852119 0.495291099533015 0.929304854878186 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 14/1109 229/18639 0.0611353711790393 1.02750422308937 0.497827173516673 0.929304854878186 GO:0019199 transmembrane receptor protein kinase activity 5/1109 78/18639 0.0641025641025641 1.07737393355067 0.498317502688716 0.929304854878186 GO:0004677 DNA-dependent protein kinase activity 15/1109 246/18639 0.0609756097560976 1.02481910752381 0.49918589915399 0.929304854878186 GO:0140857 histone H3T45 kinase activity 15/1109 246/18639 0.0609756097560976 1.02481910752381 0.49918589915399 0.929304854878186 GO:0046625 sphingolipid binding 2/1109 28/18639 0.0714285714285714 1.20050238309932 0.502693280715418 0.929304854878186 GO:0046875 ephrin receptor binding 2/1109 28/18639 0.0714285714285714 1.20050238309932 0.502693280715418 0.929304854878186 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 2/1109 28/18639 0.0714285714285714 1.20050238309932 0.502693280715418 0.929304854878186 GO:0035402 histone H3T11 kinase activity 15/1109 247/18639 0.0607287449392713 1.02067004231116 0.505626617142735 0.929304854878186 GO:0035403 histone H3T6 kinase activity 15/1109 247/18639 0.0607287449392713 1.02067004231116 0.505626617142735 0.929304854878186 GO:0046915 transition metal ion transmembrane transporter activity 3/1109 45/18639 0.0666666666666667 1.1204688908927 0.506146728157371 0.929304854878186 GO:0016853 isomerase activity 11/1109 180/18639 0.0611111111111111 1.0270964833183 0.508107768438754 0.929304854878186 GO:0008186 ATP-dependent activity, acting on RNA 5/1109 79/18639 0.0632911392405063 1.06373628882218 0.509702711485992 0.929304854878186 GO:0015370 solute:sodium symporter activity 5/1109 79/18639 0.0632911392405063 1.06373628882218 0.509702711485992 0.929304854878186 GO:0016835 carbon-oxygen lyase activity 5/1109 79/18639 0.0632911392405063 1.06373628882218 0.509702711485992 0.929304854878186 GO:0033293 monocarboxylic acid binding 5/1109 79/18639 0.0632911392405063 1.06373628882218 0.509702711485992 0.929304854878186 GO:0004679 AMP-activated protein kinase activity 15/1109 248/18639 0.0604838709677419 1.01655443730184 0.512048202363361 0.929304854878186 GO:0015081 sodium ion transmembrane transporter activity 10/1109 164/18639 0.0609756097560976 1.02481910752381 0.514812228381238 0.929304854878186 GO:1901682 sulfur compound transmembrane transporter activity 4/1109 63/18639 0.0634920634920635 1.06711322942162 0.520909390272057 0.929304854878186 GO:0030276 clathrin binding 3/1109 46/18639 0.0652173913043478 1.09611087152546 0.521080951893948 0.929304854878186 GO:0000995 RNA polymerase III general transcription initiation factor activity 1/1109 12/18639 0.0833333333333333 1.40058611361587 0.521133600886501 0.929304854878186 GO:0003720 telomerase activity 1/1109 12/18639 0.0833333333333333 1.40058611361587 0.521133600886501 0.929304854878186 GO:0004126 cytidine deaminase activity 1/1109 12/18639 0.0833333333333333 1.40058611361587 0.521133600886501 0.929304854878186 GO:0005049 nuclear export signal receptor activity 1/1109 12/18639 0.0833333333333333 1.40058611361587 0.521133600886501 0.929304854878186 GO:0005095 GTPase inhibitor activity 1/1109 12/18639 0.0833333333333333 1.40058611361587 0.521133600886501 0.929304854878186 GO:0005165 neurotrophin receptor binding 1/1109 12/18639 0.0833333333333333 1.40058611361587 0.521133600886501 0.929304854878186 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 1/1109 12/18639 0.0833333333333333 1.40058611361587 0.521133600886501 0.929304854878186 GO:0015269 calcium-activated potassium channel activity 1/1109 12/18639 0.0833333333333333 1.40058611361587 0.521133600886501 0.929304854878186 GO:0015368 calcium:monoatomic cation antiporter activity 1/1109 12/18639 0.0833333333333333 1.40058611361587 0.521133600886501 0.929304854878186 GO:0016840 carbon-nitrogen lyase activity 1/1109 12/18639 0.0833333333333333 1.40058611361587 0.521133600886501 0.929304854878186 GO:0035497 cAMP response element binding 1/1109 12/18639 0.0833333333333333 1.40058611361587 0.521133600886501 0.929304854878186 GO:0042301 phosphate ion binding 1/1109 12/18639 0.0833333333333333 1.40058611361587 0.521133600886501 0.929304854878186 GO:0070679 inositol 1,4,5 trisphosphate binding 1/1109 12/18639 0.0833333333333333 1.40058611361587 0.521133600886501 0.929304854878186 GO:0141221 histone deacetylase activity, hydrolytic mechanism 1/1109 12/18639 0.0833333333333333 1.40058611361587 0.521133600886501 0.929304854878186 GO:0003785 actin monomer binding 2/1109 29/18639 0.0689655172413793 1.15910574919934 0.521627613133383 0.929304854878186 GO:0004181 metallocarboxypeptidase activity 2/1109 29/18639 0.0689655172413793 1.15910574919934 0.521627613133383 0.929304854878186 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 2/1109 29/18639 0.0689655172413793 1.15910574919934 0.521627613133383 0.929304854878186 GO:0051861 glycolipid binding 2/1109 29/18639 0.0689655172413793 1.15910574919934 0.521627613133383 0.929304854878186 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 8/1109 132/18639 0.0606060606060606 1.01860808262972 0.530602672186946 0.929304854878186 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 16/1109 268/18639 0.0597014925373134 1.00340497691883 0.531418017586862 0.929304854878186 GO:0061733 protein-lysine-acetyltransferase activity 3/1109 47/18639 0.0638297872340425 1.07278936362067 0.535765265445663 0.929304854878186 GO:0019842 vitamin binding 9/1109 150/18639 0.06 1.00842200180343 0.538663669593005 0.929304854878186 GO:0008106 alcohol dehydrogenase (NADP+) activity 2/1109 30/18639 0.0666666666666667 1.1204688908927 0.540071654334421 0.929304854878186 GO:0031210 phosphatidylcholine binding 2/1109 30/18639 0.0666666666666667 1.1204688908927 0.540071654334421 0.929304854878186 GO:0031624 ubiquitin conjugating enzyme binding 2/1109 30/18639 0.0666666666666667 1.1204688908927 0.540071654334421 0.929304854878186 GO:0051721 protein phosphatase 2A binding 2/1109 30/18639 0.0666666666666667 1.1204688908927 0.540071654334421 0.929304854878186 GO:0015078 proton transmembrane transporter activity 11/1109 185/18639 0.0594594594594595 0.999337118904297 0.545265795390267 0.929304854878186 GO:0003964 RNA-directed DNA polymerase activity 1/1109 13/18639 0.0769230769230769 1.2928487202608 0.549643980261433 0.929304854878186 GO:0004465 lipoprotein lipase activity 1/1109 13/18639 0.0769230769230769 1.2928487202608 0.549643980261433 0.929304854878186 GO:0005035 death receptor activity 1/1109 13/18639 0.0769230769230769 1.2928487202608 0.549643980261433 0.929304854878186 GO:0005338 nucleotide-sugar transmembrane transporter activity 1/1109 13/18639 0.0769230769230769 1.2928487202608 0.549643980261433 0.929304854878186 GO:0008253 5'-nucleotidase activity 1/1109 13/18639 0.0769230769230769 1.2928487202608 0.549643980261433 0.929304854878186 GO:0008417 fucosyltransferase activity 1/1109 13/18639 0.0769230769230769 1.2928487202608 0.549643980261433 0.929304854878186 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 1/1109 13/18639 0.0769230769230769 1.2928487202608 0.549643980261433 0.929304854878186 GO:0017154 semaphorin receptor activity 1/1109 13/18639 0.0769230769230769 1.2928487202608 0.549643980261433 0.929304854878186 GO:0019104 DNA N-glycosylase activity 1/1109 13/18639 0.0769230769230769 1.2928487202608 0.549643980261433 0.929304854878186 GO:0031432 titin binding 1/1109 13/18639 0.0769230769230769 1.2928487202608 0.549643980261433 0.929304854878186 GO:0032396 inhibitory MHC class I receptor activity 1/1109 13/18639 0.0769230769230769 1.2928487202608 0.549643980261433 0.929304854878186 GO:0035673 oligopeptide transmembrane transporter activity 1/1109 13/18639 0.0769230769230769 1.2928487202608 0.549643980261433 0.929304854878186 GO:0046974 histone H3K9 methyltransferase activity 1/1109 13/18639 0.0769230769230769 1.2928487202608 0.549643980261433 0.929304854878186 GO:0046975 histone H3K36 methyltransferase activity 1/1109 13/18639 0.0769230769230769 1.2928487202608 0.549643980261433 0.929304854878186 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 1/1109 13/18639 0.0769230769230769 1.2928487202608 0.549643980261433 0.929304854878186 GO:0071837 HMG box domain binding 1/1109 13/18639 0.0769230769230769 1.2928487202608 0.549643980261433 0.929304854878186 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 1/1109 13/18639 0.0769230769230769 1.2928487202608 0.549643980261433 0.929304854878186 GO:0140333 glycerophospholipid flippase activity 1/1109 13/18639 0.0769230769230769 1.2928487202608 0.549643980261433 0.929304854878186 GO:0030165 PDZ domain binding 5/1109 83/18639 0.0602409638554217 1.01247188936087 0.554119307518097 0.929304854878186 GO:0005164 tumor necrosis factor receptor binding 2/1109 31/18639 0.0645161290322581 1.08432473312196 0.558016675881313 0.929304854878186 GO:0005184 neuropeptide hormone activity 2/1109 31/18639 0.0645161290322581 1.08432473312196 0.558016675881313 0.929304854878186 GO:0005452 solute:inorganic anion antiporter activity 2/1109 31/18639 0.0645161290322581 1.08432473312196 0.558016675881313 0.929304854878186 GO:0047499 calcium-independent phospholipase A2 activity 2/1109 31/18639 0.0645161290322581 1.08432473312196 0.558016675881313 0.929304854878186 GO:0140457 protein demethylase activity 2/1109 31/18639 0.0645161290322581 1.08432473312196 0.558016675881313 0.929304854878186 GO:0022853 active monoatomic ion transmembrane transporter activity 7/1109 118/18639 0.0593220338983051 0.997027402912992 0.558531229343155 0.929304854878186 GO:0005004 GPI-linked ephrin receptor activity 3/1109 49/18639 0.0612244897959184 1.02900204265656 0.564346147867268 0.929304854878186 GO:0005008 hepatocyte growth factor receptor activity 3/1109 49/18639 0.0612244897959184 1.02900204265656 0.564346147867268 0.929304854878186 GO:0005009 insulin receptor activity 3/1109 49/18639 0.0612244897959184 1.02900204265656 0.564346147867268 0.929304854878186 GO:0005011 macrophage colony-stimulating factor receptor activity 3/1109 49/18639 0.0612244897959184 1.02900204265656 0.564346147867268 0.929304854878186 GO:0005018 platelet-derived growth factor alpha-receptor activity 3/1109 49/18639 0.0612244897959184 1.02900204265656 0.564346147867268 0.929304854878186 GO:0005020 stem cell factor receptor activity 3/1109 49/18639 0.0612244897959184 1.02900204265656 0.564346147867268 0.929304854878186 GO:0008288 boss receptor activity 3/1109 49/18639 0.0612244897959184 1.02900204265656 0.564346147867268 0.929304854878186 GO:0036332 placental growth factor receptor activity 3/1109 49/18639 0.0612244897959184 1.02900204265656 0.564346147867268 0.929304854878186 GO:0038062 protein tyrosine kinase collagen receptor activity 3/1109 49/18639 0.0612244897959184 1.02900204265656 0.564346147867268 0.929304854878186 GO:0060175 brain-derived neurotrophic factor receptor activity 3/1109 49/18639 0.0612244897959184 1.02900204265656 0.564346147867268 0.929304854878186 GO:0044325 transmembrane transporter binding 8/1109 136/18639 0.0588235294117647 0.988649021375908 0.564962046445093 0.929304854878186 GO:0140597 protein carrier chaperone 11/1109 188/18639 0.0585106382978723 0.983390249985611 0.567070023414369 0.929304854878186 GO:0016500 protein-hormone receptor activity 4/1109 67/18639 0.0597014925373134 1.00340497691883 0.570157227965954 0.929304854878186 GO:1901681 sulfur compound binding 16/1109 275/18639 0.0581818181818182 0.977863759324535 0.573771446820603 0.929304854878186 GO:0022884 macromolecule transmembrane transporter activity 2/1109 32/18639 0.0625 1.0504395852119 0.575456720458657 0.929304854878186 GO:0047498 calcium-dependent phospholipase A2 activity 2/1109 32/18639 0.0625 1.0504395852119 0.575456720458657 0.929304854878186 GO:0120015 sterol transfer activity 2/1109 32/18639 0.0625 1.0504395852119 0.575456720458657 0.929304854878186 GO:0160041 neuropeptide activity 2/1109 32/18639 0.0625 1.0504395852119 0.575456720458657 0.929304854878186 GO:0008191 metalloendopeptidase inhibitor activity 1/1109 14/18639 0.0714285714285714 1.20050238309932 0.576458370140638 0.929304854878186 GO:0008195 phosphatidate phosphatase activity 1/1109 14/18639 0.0714285714285714 1.20050238309932 0.576458370140638 0.929304854878186 GO:0008474 palmitoyl-(protein) hydrolase activity 1/1109 14/18639 0.0714285714285714 1.20050238309932 0.576458370140638 0.929304854878186 GO:0015926 glucosidase activity 1/1109 14/18639 0.0714285714285714 1.20050238309932 0.576458370140638 0.929304854878186 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 1/1109 14/18639 0.0714285714285714 1.20050238309932 0.576458370140638 0.929304854878186 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 1/1109 14/18639 0.0714285714285714 1.20050238309932 0.576458370140638 0.929304854878186 GO:0031404 chloride ion binding 1/1109 14/18639 0.0714285714285714 1.20050238309932 0.576458370140638 0.929304854878186 GO:0032454 histone H3K9 demethylase activity 1/1109 14/18639 0.0714285714285714 1.20050238309932 0.576458370140638 0.929304854878186 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 1/1109 14/18639 0.0714285714285714 1.20050238309932 0.576458370140638 0.929304854878186 GO:0061665 SUMO ligase activity 1/1109 14/18639 0.0714285714285714 1.20050238309932 0.576458370140638 0.929304854878186 GO:0070742 C2H2 zinc finger domain binding 1/1109 14/18639 0.0714285714285714 1.20050238309932 0.576458370140638 0.929304854878186 GO:0098599 palmitoyl hydrolase activity 1/1109 14/18639 0.0714285714285714 1.20050238309932 0.576458370140638 0.929304854878186 GO:1901474 azole transmembrane transporter activity 1/1109 14/18639 0.0714285714285714 1.20050238309932 0.576458370140638 0.929304854878186 GO:0032182 ubiquitin-like protein binding 7/1109 120/18639 0.0583333333333333 0.980410279531109 0.576561484335997 0.929304854878186 GO:0005006 epidermal growth factor receptor activity 3/1109 50/18639 0.06 1.00842200180343 0.578226781081782 0.929304854878186 GO:0005007 fibroblast growth factor receptor activity 3/1109 50/18639 0.06 1.00842200180343 0.578226781081782 0.929304854878186 GO:0005017 platelet-derived growth factor receptor activity 3/1109 50/18639 0.06 1.00842200180343 0.578226781081782 0.929304854878186 GO:0005019 platelet-derived growth factor beta-receptor activity 3/1109 50/18639 0.06 1.00842200180343 0.578226781081782 0.929304854878186 GO:0015605 organophosphate ester transmembrane transporter activity 3/1109 50/18639 0.06 1.00842200180343 0.578226781081782 0.929304854878186 GO:0032813 tumor necrosis factor receptor superfamily binding 3/1109 50/18639 0.06 1.00842200180343 0.578226781081782 0.929304854878186 GO:0008017 microtubule binding 16/1109 276/18639 0.0579710144927536 0.974320774689301 0.57970563801805 0.929304854878186 GO:0005253 monoatomic anion channel activity 6/1109 103/18639 0.058252427184466 0.979050487187793 0.580651263007234 0.929304854878186 GO:0030145 manganese ion binding 4/1109 68/18639 0.0588235294117647 0.988649021375908 0.582020293736836 0.929304854878186 GO:0032934 sterol binding 4/1109 68/18639 0.0588235294117647 0.988649021375908 0.582020293736836 0.929304854878186 GO:0005539 glycosaminoglycan binding 14/1109 242/18639 0.0578512396694215 0.972307715237464 0.58249510221388 0.929304854878186 GO:0004540 RNA nuclease activity 7/1109 121/18639 0.0578512396694215 0.972307715237464 0.585443509186386 0.929304854878186 GO:0001217 DNA-binding transcription repressor activity 16/1109 278/18639 0.0575539568345324 0.967311272713119 0.591475555362405 0.929304854878186 GO:0005010 insulin-like growth factor receptor activity 3/1109 51/18639 0.0588235294117647 0.988649021375908 0.591825499325172 0.929304854878186 GO:0005021 vascular endothelial growth factor receptor activity 3/1109 51/18639 0.0588235294117647 0.988649021375908 0.591825499325172 0.929304854878186 GO:0005030 neurotrophin receptor activity 3/1109 51/18639 0.0588235294117647 0.988649021375908 0.591825499325172 0.929304854878186 GO:0019239 deaminase activity 2/1109 33/18639 0.0606060606060606 1.01860808262972 0.592388303548811 0.929304854878186 GO:0019956 chemokine binding 2/1109 33/18639 0.0606060606060606 1.01860808262972 0.592388303548811 0.929304854878186 GO:0140311 protein sequestering activity 2/1109 33/18639 0.0606060606060606 1.01860808262972 0.592388303548811 0.929304854878186 GO:0002039 p53 binding 4/1109 69/18639 0.0579710144927536 0.974320774689301 0.593692438362069 0.929304854878186 GO:0008080 N-acetyltransferase activity 4/1109 69/18639 0.0579710144927536 0.974320774689301 0.593692438362069 0.929304854878186 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 7/1109 122/18639 0.0573770491803279 0.964337979866665 0.594232800320333 0.929304854878186 GO:0004129 cytochrome-c oxidase activity 1/1109 15/18639 0.0666666666666667 1.1204688908927 0.601677573765553 0.929304854878186 GO:0004467 long-chain fatty acid-CoA ligase activity 1/1109 15/18639 0.0666666666666667 1.1204688908927 0.601677573765553 0.929304854878186 GO:0005041 low-density lipoprotein particle receptor activity 1/1109 15/18639 0.0666666666666667 1.1204688908927 0.601677573765553 0.929304854878186 GO:0005402 carbohydrate:monoatomic cation symporter activity 1/1109 15/18639 0.0666666666666667 1.1204688908927 0.601677573765553 0.929304854878186 GO:0005523 tropomyosin binding 1/1109 15/18639 0.0666666666666667 1.1204688908927 0.601677573765553 0.929304854878186 GO:0008242 omega peptidase activity 1/1109 15/18639 0.0666666666666667 1.1204688908927 0.601677573765553 0.929304854878186 GO:0008252 nucleotidase activity 1/1109 15/18639 0.0666666666666667 1.1204688908927 0.601677573765553 0.929304854878186 GO:0015116 sulfate transmembrane transporter activity 1/1109 15/18639 0.0666666666666667 1.1204688908927 0.601677573765553 0.929304854878186 GO:0015929 hexosaminidase activity 1/1109 15/18639 0.0666666666666667 1.1204688908927 0.601677573765553 0.929304854878186 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 1/1109 15/18639 0.0666666666666667 1.1204688908927 0.601677573765553 0.929304854878186 GO:0016846 carbon-sulfur lyase activity 1/1109 15/18639 0.0666666666666667 1.1204688908927 0.601677573765553 0.929304854878186 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 1/1109 15/18639 0.0666666666666667 1.1204688908927 0.601677573765553 0.929304854878186 GO:0017081 chloride channel regulator activity 1/1109 15/18639 0.0666666666666667 1.1204688908927 0.601677573765553 0.929304854878186 GO:0031005 filamin binding 1/1109 15/18639 0.0666666666666667 1.1204688908927 0.601677573765553 0.929304854878186 GO:0047372 monoacylglycerol lipase activity 1/1109 15/18639 0.0666666666666667 1.1204688908927 0.601677573765553 0.929304854878186 GO:0048531 beta-1,3-galactosyltransferase activity 1/1109 15/18639 0.0666666666666667 1.1204688908927 0.601677573765553 0.929304854878186 GO:0061578 K63-linked deubiquitinase activity 1/1109 15/18639 0.0666666666666667 1.1204688908927 0.601677573765553 0.929304854878186 GO:0140161 monocarboxylate:sodium symporter activity 1/1109 15/18639 0.0666666666666667 1.1204688908927 0.601677573765553 0.929304854878186 GO:0141050 histone H3K deacetylase activity 1/1109 15/18639 0.0666666666666667 1.1204688908927 0.601677573765553 0.929304854878186 GO:0141051 histone H4K deacetylase activity 1/1109 15/18639 0.0666666666666667 1.1204688908927 0.601677573765553 0.929304854878186 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 3/1109 52/18639 0.0576923076923077 0.969636540195602 0.605137107438459 0.929304854878186 GO:0008175 tRNA methyltransferase activity 2/1109 34/18639 0.0588235294117647 0.988649021375908 0.608810140745686 0.929304854878186 GO:0008376 acetylgalactosaminyltransferase activity 2/1109 34/18639 0.0588235294117647 0.988649021375908 0.608810140745686 0.929304854878186 GO:0015035 protein-disulfide reductase activity 2/1109 34/18639 0.0588235294117647 0.988649021375908 0.608810140745686 0.929304854878186 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 2/1109 34/18639 0.0588235294117647 0.988649021375908 0.608810140745686 0.929304854878186 GO:0019825 oxygen binding 2/1109 34/18639 0.0588235294117647 0.988649021375908 0.608810140745686 0.929304854878186 GO:0000149 SNARE binding 6/1109 106/18639 0.0566037735849057 0.951341511135308 0.608931119480984 0.929304854878186 GO:0003727 single-stranded RNA binding 5/1109 89/18639 0.0561797752808989 0.944215357493845 0.616776005769935 0.929304854878186 GO:0019888 protein phosphatase regulator activity 6/1109 107/18639 0.0560747663551402 0.942450468975165 0.618120424406802 0.929304854878186 GO:0004864 protein phosphatase inhibitor activity 3/1109 53/18639 0.0566037735849057 0.951341511135308 0.618157402821549 0.929304854878186 GO:0005003 ephrin receptor activity 3/1109 53/18639 0.0566037735849057 0.951341511135308 0.618157402821549 0.929304854878186 GO:0005005 transmembrane-ephrin receptor activity 3/1109 53/18639 0.0566037735849057 0.951341511135308 0.618157402821549 0.929304854878186 GO:0034212 protein N-acetyltransferase activity 3/1109 53/18639 0.0566037735849057 0.951341511135308 0.618157402821549 0.929304854878186 GO:0051018 protein kinase A binding 3/1109 53/18639 0.0566037735849057 0.951341511135308 0.618157402821549 0.929304854878186 GO:0004623 phospholipase A2 activity 2/1109 35/18639 0.0571428571428571 0.960401906479454 0.624722898715946 0.929304854878186 GO:0005154 epidermal growth factor receptor binding 2/1109 35/18639 0.0571428571428571 0.960401906479454 0.624722898715946 0.929304854878186 GO:0005343 organic acid:sodium symporter activity 2/1109 35/18639 0.0571428571428571 0.960401906479454 0.624722898715946 0.929304854878186 GO:0034061 DNA polymerase activity 2/1109 35/18639 0.0571428571428571 0.960401906479454 0.624722898715946 0.929304854878186 GO:0061631 ubiquitin conjugating enzyme activity 2/1109 35/18639 0.0571428571428571 0.960401906479454 0.624722898715946 0.929304854878186 GO:0000062 fatty-acyl-CoA binding 1/1109 16/18639 0.0625 1.0504395852119 0.625396408102645 0.929304854878186 GO:0003688 DNA replication origin binding 1/1109 16/18639 0.0625 1.0504395852119 0.625396408102645 0.929304854878186 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 1/1109 16/18639 0.0625 1.0504395852119 0.625396408102645 0.929304854878186 GO:0004708 MAP kinase kinase activity 1/1109 16/18639 0.0625 1.0504395852119 0.625396408102645 0.929304854878186 GO:0005149 interleukin-1 receptor binding 1/1109 16/18639 0.0625 1.0504395852119 0.625396408102645 0.929304854878186 GO:0005521 lamin binding 1/1109 16/18639 0.0625 1.0504395852119 0.625396408102645 0.929304854878186 GO:0008142 oxysterol binding 1/1109 16/18639 0.0625 1.0504395852119 0.625396408102645 0.929304854878186 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 1/1109 16/18639 0.0625 1.0504395852119 0.625396408102645 0.929304854878186 GO:0016675 oxidoreductase activity, acting on a heme group of donors 1/1109 16/18639 0.0625 1.0504395852119 0.625396408102645 0.929304854878186 GO:0016722 oxidoreductase activity, acting on metal ions 1/1109 16/18639 0.0625 1.0504395852119 0.625396408102645 0.929304854878186 GO:0022841 potassium ion leak channel activity 1/1109 16/18639 0.0625 1.0504395852119 0.625396408102645 0.929304854878186 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity 1/1109 16/18639 0.0625 1.0504395852119 0.625396408102645 0.929304854878186 GO:0022858 alanine transmembrane transporter activity 1/1109 16/18639 0.0625 1.0504395852119 0.625396408102645 0.929304854878186 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 1/1109 16/18639 0.0625 1.0504395852119 0.625396408102645 0.929304854878186 GO:0097027 ubiquitin-protein transferase activator activity 1/1109 16/18639 0.0625 1.0504395852119 0.625396408102645 0.929304854878186 GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 1/1109 16/18639 0.0625 1.0504395852119 0.625396408102645 0.929304854878186 GO:0140327 flippase activity 1/1109 16/18639 0.0625 1.0504395852119 0.625396408102645 0.929304854878186 GO:0140104 molecular carrier activity 14/1109 249/18639 0.0562248995983936 0.944973763403479 0.625578016983016 0.929304854878186 GO:0016757 glycosyltransferase activity 15/1109 267/18639 0.0561797752808989 0.944215357493845 0.628585192441214 0.929304854878186 GO:0019955 cytokine binding 8/1109 144/18639 0.0555555555555556 0.933724075743913 0.630075916557924 0.929304854878186 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 3/1109 54/18639 0.0555555555555556 0.933724075743913 0.630883112933008 0.929304854878186 GO:0042826 histone deacetylase binding 7/1109 127/18639 0.0551181102362205 0.92637191766719 0.636696988904507 0.929304854878186 GO:0004033 aldo-keto reductase (NADPH) activity 2/1109 36/18639 0.0555555555555556 0.933724075743913 0.64012896796291 0.929304854878186 GO:0004869 cysteine-type endopeptidase inhibitor activity 2/1109 36/18639 0.0555555555555556 0.933724075743913 0.64012896796291 0.929304854878186 GO:0016409 palmitoyltransferase activity 2/1109 36/18639 0.0555555555555556 0.933724075743913 0.64012896796291 0.929304854878186 GO:0015291 secondary active transmembrane transporter activity 16/1109 287/18639 0.0557491289198606 0.936977469736053 0.642620150707342 0.929304854878186 GO:0140313 molecular sequestering activity 3/1109 55/18639 0.0545454545454545 0.916747274366751 0.643311834503404 0.929304854878186 GO:0005092 GDP-dissociation inhibitor activity 1/1109 17/18639 0.0588235294117647 0.988649021375908 0.647704059040419 0.929304854878186 GO:0008429 phosphatidylethanolamine binding 1/1109 17/18639 0.0588235294117647 0.988649021375908 0.647704059040419 0.929304854878186 GO:0015278 intracellularly gated calcium channel activity 1/1109 17/18639 0.0588235294117647 0.988649021375908 0.647704059040419 0.929304854878186 GO:0017110 nucleoside diphosphate phosphatase activity 1/1109 17/18639 0.0588235294117647 0.988649021375908 0.647704059040419 0.929304854878186 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 1/1109 17/18639 0.0588235294117647 0.988649021375908 0.647704059040419 0.929304854878186 GO:0031489 myosin V binding 1/1109 17/18639 0.0588235294117647 0.988649021375908 0.647704059040419 0.929304854878186 GO:0032977 membrane insertase activity 1/1109 17/18639 0.0588235294117647 0.988649021375908 0.647704059040419 0.929304854878186 GO:0038191 neuropilin binding 1/1109 17/18639 0.0588235294117647 0.988649021375908 0.647704059040419 0.929304854878186 GO:0048038 quinone binding 1/1109 17/18639 0.0588235294117647 0.988649021375908 0.647704059040419 0.929304854878186 GO:0070403 NAD+ binding 1/1109 17/18639 0.0588235294117647 0.988649021375908 0.647704059040419 0.929304854878186 GO:1901567 fatty acid derivative binding 1/1109 17/18639 0.0588235294117647 0.988649021375908 0.647704059040419 0.929304854878186 GO:0015085 calcium ion transmembrane transporter activity 8/1109 147/18639 0.054421768707483 0.914668482361385 0.653064664493463 0.929304854878186 GO:0015103 inorganic anion transmembrane transporter activity 9/1109 165/18639 0.0545454545454545 0.916747274366751 0.653706890394503 0.929304854878186 GO:0019213 deacetylase activity 2/1109 37/18639 0.0540540540540541 0.908488289912997 0.655032255683963 0.929304854878186 GO:0043394 proteoglycan binding 2/1109 37/18639 0.0540540540540541 0.908488289912997 0.655032255683963 0.929304854878186 GO:0070001 aspartic-type peptidase activity 2/1109 37/18639 0.0540540540540541 0.908488289912997 0.655032255683963 0.929304854878186 GO:0019212 phosphatase inhibitor activity 3/1109 56/18639 0.0535714285714286 0.900376787324488 0.655441974610136 0.929304854878186 GO:0170055 lipid transmembrane transporter activity 3/1109 56/18639 0.0535714285714286 0.900376787324488 0.655441974610136 0.929304854878186 GO:0019003 GDP binding 4/1109 75/18639 0.0533333333333333 0.896375112714157 0.659493790627992 0.929304854878186 GO:0015399 primary active transmembrane transporter activity 9/1109 166/18639 0.0542168674698795 0.911224700424783 0.660772024020806 0.929304854878186 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 7/1109 130/18639 0.0538461538461538 0.904994104182562 0.660910984109443 0.929304854878186 GO:0016410 N-acyltransferase activity 5/1109 94/18639 0.0531914893617021 0.893991136350555 0.664811456628607 0.929304854878186 GO:0015932 nucleobase-containing compound transmembrane transporter activity 3/1109 57/18639 0.0526315789473684 0.884580703336339 0.667272693730299 0.929304854878186 GO:0016504 peptidase activator activity 3/1109 57/18639 0.0526315789473684 0.884580703336339 0.667272693730299 0.929304854878186 GO:0000900 mRNA regulatory element binding translation repressor activity 1/1109 18/18639 0.0555555555555556 0.933724075743913 0.668684415528668 0.929304854878186 GO:0004706 JUN kinase kinase kinase activity 1/1109 18/18639 0.0555555555555556 0.933724075743913 0.668684415528668 0.929304854878186 GO:0004970 glutamate-gated receptor activity 1/1109 18/18639 0.0555555555555556 0.933724075743913 0.668684415528668 0.929304854878186 GO:0008308 voltage-gated monoatomic anion channel activity 1/1109 18/18639 0.0555555555555556 0.933724075743913 0.668684415528668 0.929304854878186 GO:0015172 acidic amino acid transmembrane transporter activity 1/1109 18/18639 0.0555555555555556 0.933724075743913 0.668684415528668 0.929304854878186 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 1/1109 18/18639 0.0555555555555556 0.933724075743913 0.668684415528668 0.929304854878186 GO:0022851 GABA-gated chloride ion channel activity 1/1109 18/18639 0.0555555555555556 0.933724075743913 0.668684415528668 0.929304854878186 GO:0030228 lipoprotein particle receptor activity 1/1109 18/18639 0.0555555555555556 0.933724075743913 0.668684415528668 0.929304854878186 GO:0031690 adrenergic receptor binding 1/1109 18/18639 0.0555555555555556 0.933724075743913 0.668684415528668 0.929304854878186 GO:0032393 MHC class I receptor activity 1/1109 18/18639 0.0555555555555556 0.933724075743913 0.668684415528668 0.929304854878186 GO:0035615 clathrin adaptor activity 1/1109 18/18639 0.0555555555555556 0.933724075743913 0.668684415528668 0.929304854878186 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 1/1109 18/18639 0.0555555555555556 0.933724075743913 0.668684415528668 0.929304854878186 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 1/1109 18/18639 0.0555555555555556 0.933724075743913 0.668684415528668 0.929304854878186 GO:0005109 frizzled binding 2/1109 38/18639 0.0526315789473684 0.884580703336339 0.669437997138217 0.929304854878186 GO:0017022 myosin binding 4/1109 76/18639 0.0526315789473684 0.884580703336339 0.66972918487295 0.929304854878186 GO:0005201 extracellular matrix structural constituent 9/1109 168/18639 0.0535714285714286 0.900376787324488 0.674648353790784 0.929304854878186 GO:0000510 H3-H4 histone complex chaperone activity 8/1109 151/18639 0.0529801324503311 0.89043885368956 0.682384986182941 0.929304854878186 GO:0140584 chromatin extrusion motor activity 8/1109 151/18639 0.0529801324503311 0.89043885368956 0.682384986182941 0.929304854878186 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 8/1109 151/18639 0.0529801324503311 0.89043885368956 0.682384986182941 0.929304854878186 GO:0140849 ATP-dependent H2AZ histone chaperone activity 8/1109 151/18639 0.0529801324503311 0.89043885368956 0.682384986182941 0.929304854878186 GO:0004896 cytokine receptor activity 5/1109 96/18639 0.0520833333333333 0.875366321009919 0.682886205324177 0.929304854878186 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 2/1109 39/18639 0.0512820512820513 0.861899146840535 0.683352584058169 0.929304854878186 GO:0046943 carboxylic acid transmembrane transporter activity 10/1109 188/18639 0.0531914893617021 0.893991136350555 0.687517446121199 0.929304854878186 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 1/1109 19/18639 0.0526315789473684 0.884580703336339 0.688416383907311 0.929304854878186 GO:0004890 GABA-A receptor activity 1/1109 19/18639 0.0526315789473684 0.884580703336339 0.688416383907311 0.929304854878186 GO:0005346 purine ribonucleotide transmembrane transporter activity 1/1109 19/18639 0.0526315789473684 0.884580703336339 0.688416383907311 0.929304854878186 GO:0005520 insulin-like growth factor binding 1/1109 19/18639 0.0526315789473684 0.884580703336339 0.688416383907311 0.929304854878186 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 1/1109 19/18639 0.0526315789473684 0.884580703336339 0.688416383907311 0.929304854878186 GO:0022840 leak channel activity 1/1109 19/18639 0.0526315789473684 0.884580703336339 0.688416383907311 0.929304854878186 GO:0022842 narrow pore channel activity 1/1109 19/18639 0.0526315789473684 0.884580703336339 0.688416383907311 0.929304854878186 GO:0030506 ankyrin binding 1/1109 19/18639 0.0526315789473684 0.884580703336339 0.688416383907311 0.929304854878186 GO:0031420 alkali metal ion binding 1/1109 19/18639 0.0526315789473684 0.884580703336339 0.688416383907311 0.929304854878186 GO:0034987 immunoglobulin receptor binding 1/1109 19/18639 0.0526315789473684 0.884580703336339 0.688416383907311 0.929304854878186 GO:0043395 heparan sulfate proteoglycan binding 1/1109 19/18639 0.0526315789473684 0.884580703336339 0.688416383907311 0.929304854878186 GO:0070003 threonine-type peptidase activity 1/1109 19/18639 0.0526315789473684 0.884580703336339 0.688416383907311 0.929304854878186 GO:0120227 acyl-CoA binding 1/1109 19/18639 0.0526315789473684 0.884580703336339 0.688416383907311 0.929304854878186 GO:0140036 ubiquitin-modified protein reader activity 1/1109 19/18639 0.0526315789473684 0.884580703336339 0.688416383907311 0.929304854878186 GO:0015616 DNA translocase activity 8/1109 152/18639 0.0526315789473684 0.884580703336339 0.689469204530612 0.929304854878186 GO:0140674 ATP-dependent histone chaperone activity 8/1109 152/18639 0.0526315789473684 0.884580703336339 0.689469204530612 0.929304854878186 GO:0015459 potassium channel regulator activity 3/1109 59/18639 0.0508474576271186 0.854594916782565 0.690035950767908 0.929304854878186 GO:0005342 organic acid transmembrane transporter activity 10/1109 189/18639 0.0529100529100529 0.889261024518013 0.693845557446133 0.929304854878186 GO:0051020 GTPase binding 17/1109 315/18639 0.053968253968254 0.907046245008373 0.696321876830416 0.929304854878186 GO:0061775 cohesin loader activity 8/1109 153/18639 0.0522875816993464 0.878799130111919 0.696453148688678 0.929304854878186 GO:0015036 disulfide oxidoreductase activity 2/1109 40/18639 0.05 0.840351668169522 0.69678340874781 0.929304854878186 GO:0015144 carbohydrate transmembrane transporter activity 2/1109 40/18639 0.05 0.840351668169522 0.69678340874781 0.929304854878186 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 2/1109 40/18639 0.05 0.840351668169522 0.69678340874781 0.929304854878186 GO:0032451 demethylase activity 2/1109 40/18639 0.05 0.840351668169522 0.69678340874781 0.929304854878186 GO:0050997 quaternary ammonium group binding 2/1109 40/18639 0.05 0.840351668169522 0.69678340874781 0.929304854878186 GO:0061791 GTPase motor activity 2/1109 40/18639 0.05 0.840351668169522 0.69678340874781 0.929304854878186 GO:0071855 neuropeptide receptor binding 2/1109 40/18639 0.05 0.840351668169522 0.69678340874781 0.929304854878186 GO:1990606 membrane scission GTPase motor activity 2/1109 40/18639 0.05 0.840351668169522 0.69678340874781 0.929304854878186 GO:0022804 active transmembrane transporter activity 25/1109 457/18639 0.0547045951859956 0.919421956421797 0.697973213196564 0.929304854878186 GO:0015297 antiporter activity 7/1109 135/18639 0.0518518518518519 0.871475804027652 0.699019102845571 0.929304854878186 GO:0004714 transmembrane receptor protein tyrosine kinase activity 3/1109 60/18639 0.05 0.840351668169522 0.700970093416267 0.929304854878186 GO:0019208 phosphatase regulator activity 6/1109 117/18639 0.0512820512820513 0.861899146840535 0.702901869416346 0.929304854878186 GO:0016779 nucleotidyltransferase activity 7/1109 136/18639 0.0514705882352941 0.86506789370392 0.706293516758775 0.929304854878186 GO:0099094 ligand-gated monoatomic cation channel activity 7/1109 136/18639 0.0514705882352941 0.86506789370392 0.706293516758775 0.929304854878186 GO:0000339 RNA cap binding 1/1109 20/18639 0.05 0.840351668169522 0.706974183598331 0.929304854878186 GO:0001972 retinoic acid binding 1/1109 20/18639 0.05 0.840351668169522 0.706974183598331 0.929304854878186 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 1/1109 20/18639 0.05 0.840351668169522 0.706974183598331 0.929304854878186 GO:0015095 magnesium ion transmembrane transporter activity 1/1109 20/18639 0.05 0.840351668169522 0.706974183598331 0.929304854878186 GO:0016408 C-acyltransferase activity 1/1109 20/18639 0.05 0.840351668169522 0.706974183598331 0.929304854878186 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 1/1109 20/18639 0.05 0.840351668169522 0.706974183598331 0.929304854878186 GO:0052745 inositol phosphate phosphatase activity 1/1109 20/18639 0.05 0.840351668169522 0.706974183598331 0.929304854878186 GO:0140664 ATP-dependent DNA damage sensor activity 1/1109 20/18639 0.05 0.840351668169522 0.706974183598331 0.929304854878186 GO:0140939 histone H4 methyltransferase activity 1/1109 20/18639 0.05 0.840351668169522 0.706974183598331 0.929304854878186 GO:0015175 neutral L-amino acid transmembrane transporter activity 2/1109 41/18639 0.0487804878048781 0.819855286019046 0.709738722610629 0.929304854878186 GO:0061650 ubiquitin-like protein conjugating enzyme activity 2/1109 41/18639 0.0487804878048781 0.819855286019046 0.709738722610629 0.929304854878186 GO:0140318 protein transporter activity 2/1109 41/18639 0.0487804878048781 0.819855286019046 0.709738722610629 0.929304854878186 GO:0004386 helicase activity 8/1109 155/18639 0.0516129032258065 0.867459786497571 0.710117214098435 0.929304854878186 GO:0008094 ATP-dependent activity, acting on DNA 11/1109 210/18639 0.0523809523809524 0.880368414272833 0.711125281724886 0.929304854878186 GO:0015026 coreceptor activity 3/1109 61/18639 0.0491803278688525 0.826575411314284 0.711607925590233 0.929304854878186 GO:0016836 hydro-lyase activity 3/1109 61/18639 0.0491803278688525 0.826575411314284 0.711607925590233 0.929304854878186 GO:0043130 ubiquitin binding 5/1109 100/18639 0.05 0.840351668169522 0.717027448074901 0.929304854878186 GO:0033192 calmodulin-dependent protein phosphatase activity 4/1109 81/18639 0.0493827160493827 0.829976956216812 0.717690250784053 0.929304854878186 GO:0140791 histone H2AXS140 phosphatase activity 4/1109 81/18639 0.0493827160493827 0.829976956216812 0.717690250784053 0.929304854878186 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 4/1109 81/18639 0.0493827160493827 0.829976956216812 0.717690250784053 0.929304854878186 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 4/1109 81/18639 0.0493827160493827 0.829976956216812 0.717690250784053 0.929304854878186 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 4/1109 81/18639 0.0493827160493827 0.829976956216812 0.717690250784053 0.929304854878186 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 4/1109 81/18639 0.0493827160493827 0.829976956216812 0.717690250784053 0.929304854878186 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 4/1109 81/18639 0.0493827160493827 0.829976956216812 0.717690250784053 0.929304854878186 GO:1990439 MAP kinase serine/threonine phosphatase activity 4/1109 81/18639 0.0493827160493827 0.829976956216812 0.717690250784053 0.929304854878186 GO:0015179 L-amino acid transmembrane transporter activity 3/1109 62/18639 0.0483870967741935 0.813243549841473 0.72195159472719 0.929304854878186 GO:0035198 miRNA binding 2/1109 42/18639 0.0476190476190476 0.800334922066211 0.722227507944747 0.929304854878186 GO:0042056 chemoattractant activity 2/1109 42/18639 0.0476190476190476 0.800334922066211 0.722227507944747 0.929304854878186 GO:0048487 beta-tubulin binding 2/1109 42/18639 0.0476190476190476 0.800334922066211 0.722227507944747 0.929304854878186 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 1/1109 21/18639 0.0476190476190476 0.800334922066211 0.724427625264879 0.929304854878186 GO:0005123 death receptor binding 1/1109 21/18639 0.0476190476190476 0.800334922066211 0.724427625264879 0.929304854878186 GO:0009975 cyclase activity 1/1109 21/18639 0.0476190476190476 0.800334922066211 0.724427625264879 0.929304854878186 GO:0010314 phosphatidylinositol-5-phosphate binding 1/1109 21/18639 0.0476190476190476 0.800334922066211 0.724427625264879 0.929304854878186 GO:0015125 bile acid transmembrane transporter activity 1/1109 21/18639 0.0476190476190476 0.800334922066211 0.724427625264879 0.929304854878186 GO:0035613 RNA stem-loop binding 1/1109 21/18639 0.0476190476190476 0.800334922066211 0.724427625264879 0.929304854878186 GO:0036122 BMP binding 1/1109 21/18639 0.0476190476190476 0.800334922066211 0.724427625264879 0.929304854878186 GO:0072542 protein phosphatase activator activity 1/1109 21/18639 0.0476190476190476 0.800334922066211 0.724427625264879 0.929304854878186 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 4/1109 82/18639 0.0487804878048781 0.819855286019046 0.726638674894812 0.929304854878186 GO:0033549 MAP kinase phosphatase activity 4/1109 82/18639 0.0487804878048781 0.819855286019046 0.726638674894812 0.929304854878186 GO:0140658 ATP-dependent chromatin remodeler activity 8/1109 158/18639 0.0506329113924051 0.850989031057744 0.729845167148558 0.929304854878186 GO:0005507 copper ion binding 3/1109 63/18639 0.0476190476190476 0.800334922066211 0.732003704949946 0.929304854878186 GO:0022824 transmitter-gated monoatomic ion channel activity 3/1109 63/18639 0.0476190476190476 0.800334922066211 0.732003704949946 0.929304854878186 GO:0022835 transmitter-gated channel activity 3/1109 63/18639 0.0476190476190476 0.800334922066211 0.732003704949946 0.929304854878186 GO:0015108 chloride transmembrane transporter activity 6/1109 121/18639 0.0495867768595041 0.833406613060683 0.733004790436102 0.929304854878186 GO:0015171 amino acid transmembrane transporter activity 5/1109 102/18639 0.0490196078431373 0.823874184479924 0.733087104835199 0.929304854878186 GO:0005245 voltage-gated calcium channel activity 2/1109 43/18639 0.0465116279069767 0.78172248201816 0.734259361929505 0.929304854878186 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 2/1109 43/18639 0.0465116279069767 0.78172248201816 0.734259361929505 0.929304854878186 GO:0008514 organic anion transmembrane transporter activity 14/1109 269/18639 0.0520446096654275 0.874715491031473 0.735203634618484 0.929304854878186 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 4/1109 83/18639 0.0481927710843374 0.809977511488696 0.735373832736671 0.929304854878186 GO:0004407 histone deacetylase activity 1/1109 22/18639 0.0454545454545455 0.763956061972293 0.740842372476246 0.929304854878186 GO:0008649 rRNA methyltransferase activity 1/1109 22/18639 0.0454545454545455 0.763956061972293 0.740842372476246 0.929304854878186 GO:0016881 acid-amino acid ligase activity 1/1109 22/18639 0.0454545454545455 0.763956061972293 0.740842372476246 0.929304854878186 GO:0033558 protein lysine deacetylase activity 1/1109 22/18639 0.0454545454545455 0.763956061972293 0.740842372476246 0.929304854878186 GO:0034062 5'-3' RNA polymerase activity 1/1109 22/18639 0.0454545454545455 0.763956061972293 0.740842372476246 0.929304854878186 GO:0061133 endopeptidase activator activity 1/1109 22/18639 0.0454545454545455 0.763956061972293 0.740842372476246 0.929304854878186 GO:0097747 RNA polymerase activity 1/1109 22/18639 0.0454545454545455 0.763956061972293 0.740842372476246 0.929304854878186 GO:0140035 ubiquitin-like protein reader activity 1/1109 22/18639 0.0454545454545455 0.763956061972293 0.740842372476246 0.929304854878186 GO:0140517 protein-RNA adaptor activity 1/1109 22/18639 0.0454545454545455 0.763956061972293 0.740842372476246 0.929304854878186 GO:0004722 protein serine/threonine phosphatase activity 5/1109 103/18639 0.0485436893203883 0.815875405989827 0.740864443703973 0.929304854878186 GO:0016758 hexosyltransferase activity 10/1109 197/18639 0.050761421319797 0.853148901694946 0.741566500357341 0.929304854878186 GO:0003689 DNA clamp loader activity 8/1109 160/18639 0.05 0.840351668169522 0.742480610899353 0.9293809026085 GO:0017018 myosin phosphatase activity 4/1109 84/18639 0.0476190476190476 0.800334922066211 0.743896878435069 0.930084616091607 GO:0001046 core promoter sequence-specific DNA binding 2/1109 44/18639 0.0454545454545455 0.763956061972293 0.745844391808685 0.931110159354831 GO:0020037 heme binding 7/1109 142/18639 0.0492957746478873 0.828515729181219 0.747459226837987 0.931110159354831 GO:0038024 cargo receptor activity 3/1109 65/18639 0.0461538461538462 0.775709232156482 0.751245700019841 0.931110159354831 GO:0000295 adenine nucleotide transmembrane transporter activity 1/1109 23/18639 0.0434782608695652 0.730740581016976 0.756280187855945 0.931110159354831 GO:0003887 DNA-directed DNA polymerase activity 1/1109 23/18639 0.0434782608695652 0.730740581016976 0.756280187855945 0.931110159354831 GO:0004022 alcohol dehydrogenase (NAD+) activity 1/1109 23/18639 0.0434782608695652 0.730740581016976 0.756280187855945 0.931110159354831 GO:0005283 amino acid:sodium symporter activity 1/1109 23/18639 0.0434782608695652 0.730740581016976 0.756280187855945 0.931110159354831 GO:0008171 O-methyltransferase activity 1/1109 23/18639 0.0434782608695652 0.730740581016976 0.756280187855945 0.931110159354831 GO:0016849 phosphorus-oxygen lyase activity 1/1109 23/18639 0.0434782608695652 0.730740581016976 0.756280187855945 0.931110159354831 GO:0016917 GABA receptor activity 1/1109 23/18639 0.0434782608695652 0.730740581016976 0.756280187855945 0.931110159354831 GO:0031681 G-protein beta-subunit binding 1/1109 23/18639 0.0434782608695652 0.730740581016976 0.756280187855945 0.931110159354831 GO:0070577 lysine-acetylated histone binding 1/1109 23/18639 0.0434782608695652 0.730740581016976 0.756280187855945 0.931110159354831 GO:0140102 catalytic activity, acting on a rRNA 1/1109 23/18639 0.0434782608695652 0.730740581016976 0.756280187855945 0.931110159354831 GO:0008194 UDP-glycosyltransferase activity 7/1109 145/18639 0.0482758620689655 0.811374024439539 0.766440569670328 0.931110159354831 GO:0140713 histone chaperone activity 8/1109 164/18639 0.0487804878048781 0.819855286019046 0.766507048609527 0.931110159354831 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 2/1109 46/18639 0.0434782608695652 0.730740581016976 0.767716400735 0.931110159354831 GO:0008173 RNA methyltransferase activity 3/1109 67/18639 0.0447761194029851 0.752553732689124 0.769362343243376 0.931110159354831 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 3/1109 67/18639 0.0447761194029851 0.752553732689124 0.769362343243376 0.931110159354831 GO:0015149 hexose transmembrane transporter activity 1/1109 24/18639 0.0416666666666667 0.700293056807935 0.770799164632253 0.931110159354831 GO:0042625 ATPase-coupled ion transmembrane transporter activity 1/1109 24/18639 0.0416666666666667 0.700293056807935 0.770799164632253 0.931110159354831 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 1/1109 24/18639 0.0416666666666667 0.700293056807935 0.770799164632253 0.931110159354831 GO:0046961 proton-transporting ATPase activity, rotational mechanism 1/1109 24/18639 0.0416666666666667 0.700293056807935 0.770799164632253 0.931110159354831 GO:0055056 D-glucose transmembrane transporter activity 1/1109 24/18639 0.0416666666666667 0.700293056807935 0.770799164632253 0.931110159354831 GO:0070300 phosphatidic acid binding 1/1109 24/18639 0.0416666666666667 0.700293056807935 0.770799164632253 0.931110159354831 GO:0070840 dynein complex binding 1/1109 24/18639 0.0416666666666667 0.700293056807935 0.770799164632253 0.931110159354831 GO:0140033 acetylation-dependent protein binding 1/1109 24/18639 0.0416666666666667 0.700293056807935 0.770799164632253 0.931110159354831 GO:0140612 DNA damage sensor activity 1/1109 24/18639 0.0416666666666667 0.700293056807935 0.770799164632253 0.931110159354831 GO:0004197 cysteine-type endopeptidase activity 4/1109 88/18639 0.0454545454545455 0.763956061972293 0.775899645069267 0.931110159354831 GO:0005504 fatty acid binding 2/1109 47/18639 0.0425531914893617 0.715192909080444 0.778025340081193 0.931110159354831 GO:0140359 ABC-type transporter activity 2/1109 47/18639 0.0425531914893617 0.715192909080444 0.778025340081193 0.931110159354831 GO:0140938 histone H3 methyltransferase activity 2/1109 47/18639 0.0425531914893617 0.715192909080444 0.778025340081193 0.931110159354831 GO:0000030 mannosyltransferase activity 1/1109 25/18639 0.04 0.672281334535618 0.784453944456203 0.931110159354831 GO:0001848 complement binding 1/1109 25/18639 0.04 0.672281334535618 0.784453944456203 0.931110159354831 GO:0003707 nuclear steroid receptor activity 1/1109 25/18639 0.04 0.672281334535618 0.784453944456203 0.931110159354831 GO:0004709 MAP kinase kinase kinase activity 1/1109 25/18639 0.04 0.672281334535618 0.784453944456203 0.931110159354831 GO:0008483 transaminase activity 1/1109 25/18639 0.04 0.672281334535618 0.784453944456203 0.931110159354831 GO:0015645 fatty acid ligase activity 1/1109 25/18639 0.04 0.672281334535618 0.784453944456203 0.931110159354831 GO:0015662 P-type ion transporter activity 1/1109 25/18639 0.04 0.672281334535618 0.784453944456203 0.931110159354831 GO:0019211 phosphatase activator activity 1/1109 25/18639 0.04 0.672281334535618 0.784453944456203 0.931110159354831 GO:0019706 protein-cysteine S-palmitoyltransferase activity 1/1109 25/18639 0.04 0.672281334535618 0.784453944456203 0.931110159354831 GO:0019707 protein-cysteine S-acyltransferase activity 1/1109 25/18639 0.04 0.672281334535618 0.784453944456203 0.931110159354831 GO:0120515 fatty acid-CoA ligase activity 1/1109 25/18639 0.04 0.672281334535618 0.784453944456203 0.931110159354831 GO:0140358 P-type transmembrane transporter activity 1/1109 25/18639 0.04 0.672281334535618 0.784453944456203 0.931110159354831 GO:0016279 protein-lysine N-methyltransferase activity 3/1109 69/18639 0.0434782608695652 0.730740581016976 0.786386920329555 0.931110159354831 GO:0098960 postsynaptic neurotransmitter receptor activity 3/1109 69/18639 0.0434782608695652 0.730740581016976 0.786386920329555 0.931110159354831 GO:0016879 ligase activity, forming carbon-nitrogen bonds 2/1109 48/18639 0.0416666666666667 0.700293056807935 0.787931230892112 0.931110159354831 GO:0032266 phosphatidylinositol-3-phosphate binding 2/1109 48/18639 0.0416666666666667 0.700293056807935 0.787931230892112 0.931110159354831 GO:0038187 pattern recognition receptor activity 2/1109 48/18639 0.0416666666666667 0.700293056807935 0.787931230892112 0.931110159354831 GO:0016798 hydrolase activity, acting on glycosyl bonds 6/1109 130/18639 0.0461538461538462 0.775709232156482 0.792636950356137 0.931110159354831 GO:0008028 monocarboxylic acid transmembrane transporter activity 3/1109 70/18639 0.0428571428571429 0.72030142985959 0.794501154730442 0.931110159354831 GO:0016278 lysine N-methyltransferase activity 3/1109 70/18639 0.0428571428571429 0.72030142985959 0.794501154730442 0.931110159354831 GO:0016782 transferase activity, transferring sulphur-containing groups 3/1109 70/18639 0.0428571428571429 0.72030142985959 0.794501154730442 0.931110159354831 GO:0005112 Notch binding 1/1109 26/18639 0.0384615384615385 0.646424360130402 0.797295922300733 0.931110159354831 GO:0008066 glutamate receptor activity 1/1109 26/18639 0.0384615384615385 0.646424360130402 0.797295922300733 0.931110159354831 GO:0008143 poly(A) binding 1/1109 26/18639 0.0384615384615385 0.646424360130402 0.797295922300733 0.931110159354831 GO:0015145 monosaccharide transmembrane transporter activity 1/1109 26/18639 0.0384615384615385 0.646424360130402 0.797295922300733 0.931110159354831 GO:0015216 purine nucleotide transmembrane transporter activity 1/1109 26/18639 0.0384615384615385 0.646424360130402 0.797295922300733 0.931110159354831 GO:0043548 phosphatidylinositol 3-kinase binding 1/1109 26/18639 0.0384615384615385 0.646424360130402 0.797295922300733 0.931110159354831 GO:0050750 low-density lipoprotein particle receptor binding 1/1109 26/18639 0.0384615384615385 0.646424360130402 0.797295922300733 0.931110159354831 GO:0070006 metalloaminopeptidase activity 1/1109 26/18639 0.0384615384615385 0.646424360130402 0.797295922300733 0.931110159354831 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 4/1109 91/18639 0.043956043956044 0.738770697291888 0.797765532462937 0.931110159354831 GO:0031267 small GTPase binding 14/1109 283/18639 0.049469964664311 0.83144334659882 0.798299910314946 0.931110159354831 GO:0005262 calcium channel activity 6/1109 131/18639 0.0458015267175573 0.769787787636203 0.798583001687247 0.931110159354831 GO:0046906 tetrapyrrole binding 7/1109 152/18639 0.0460526315789474 0.774008115419297 0.806630888423695 0.939487740634657 GO:0005044 scavenger receptor activity 1/1109 27/18639 0.037037037037037 0.622482717162609 0.809373439206577 0.93966703123237 GO:0016405 CoA-ligase activity 1/1109 27/18639 0.037037037037037 0.622482717162609 0.809373439206577 0.93966703123237 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 1/1109 27/18639 0.037037037037037 0.622482717162609 0.809373439206577 0.93966703123237 GO:0005048 signal sequence binding 2/1109 51/18639 0.0392156862745098 0.659099347583939 0.815345076208434 0.942802856914669 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 3/1109 73/18639 0.0410958904109589 0.690700001235224 0.817311173957902 0.942802856914669 GO:0005242 inward rectifier potassium channel activity 1/1109 28/18639 0.0357142857142857 0.600251191549659 0.820731963595139 0.942802856914669 GO:0008527 taste receptor activity 1/1109 28/18639 0.0357142857142857 0.600251191549659 0.820731963595139 0.942802856914669 GO:0019789 SUMO transferase activity 1/1109 28/18639 0.0357142857142857 0.600251191549659 0.820731963595139 0.942802856914669 GO:0045499 chemorepellent activity 1/1109 28/18639 0.0357142857142857 0.600251191549659 0.820731963595139 0.942802856914669 GO:0051119 sugar transmembrane transporter activity 1/1109 28/18639 0.0357142857142857 0.600251191549659 0.820731963595139 0.942802856914669 GO:0051393 alpha-actinin binding 1/1109 28/18639 0.0357142857142857 0.600251191549659 0.820731963595139 0.942802856914669 GO:0051537 2 iron, 2 sulfur cluster binding 1/1109 28/18639 0.0357142857142857 0.600251191549659 0.820731963595139 0.942802856914669 GO:0141052 histone H3 demethylase activity 1/1109 28/18639 0.0357142857142857 0.600251191549659 0.820731963595139 0.942802856914669 GO:0003678 DNA helicase activity 3/1109 74/18639 0.0405405405405405 0.681366217434748 0.824420973641434 0.945046779258443 GO:0031491 nucleosome binding 3/1109 74/18639 0.0405405405405405 0.681366217434748 0.824420973641434 0.945046779258443 GO:0005416 amino acid:monoatomic cation symporter activity 1/1109 29/18639 0.0344827586206897 0.57955287459967 0.831414261825916 0.945561174700494 GO:0016417 S-acyltransferase activity 1/1109 29/18639 0.0344827586206897 0.57955287459967 0.831414261825916 0.945561174700494 GO:0035250 UDP-galactosyltransferase activity 1/1109 29/18639 0.0344827586206897 0.57955287459967 0.831414261825916 0.945561174700494 GO:0099604 ligand-gated calcium channel activity 1/1109 29/18639 0.0344827586206897 0.57955287459967 0.831414261825916 0.945561174700494 GO:0008146 sulfotransferase activity 2/1109 53/18639 0.0377358490566038 0.634227674090205 0.831815982886201 0.945561174700494 GO:0016251 RNA polymerase II general transcription initiation factor activity 2/1109 53/18639 0.0377358490566038 0.634227674090205 0.831815982886201 0.945561174700494 GO:1901505 carbohydrate derivative transmembrane transporter activity 2/1109 53/18639 0.0377358490566038 0.634227674090205 0.831815982886201 0.945561174700494 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 2/1109 53/18639 0.0377358490566038 0.634227674090205 0.831815982886201 0.945561174700494 GO:0030594 neurotransmitter receptor activity 4/1109 97/18639 0.0412371134020619 0.693073540758369 0.836312416642117 0.948342715248854 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 2/1109 54/18639 0.037037037037037 0.622482717162609 0.839544170192093 0.948342715248854 GO:0140463 chromatin-protein adaptor activity 2/1109 54/18639 0.037037037037037 0.622482717162609 0.839544170192093 0.948342715248854 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 1/1109 30/18639 0.0333333333333333 0.560234445446348 0.841460558635967 0.948342715248854 GO:0015215 nucleotide transmembrane transporter activity 1/1109 30/18639 0.0333333333333333 0.560234445446348 0.841460558635967 0.948342715248854 GO:0016769 transferase activity, transferring nitrogenous groups 1/1109 30/18639 0.0333333333333333 0.560234445446348 0.841460558635967 0.948342715248854 GO:0032452 histone demethylase activity 1/1109 30/18639 0.0333333333333333 0.560234445446348 0.841460558635967 0.948342715248854 GO:0048019 receptor antagonist activity 1/1109 30/18639 0.0333333333333333 0.560234445446348 0.841460558635967 0.948342715248854 GO:0042626 ATPase-coupled transmembrane transporter activity 4/1109 98/18639 0.0408163265306122 0.686001361771038 0.842100464321067 0.948342715248854 GO:0008374 O-acyltransferase activity 2/1109 55/18639 0.0363636363636364 0.611164849577834 0.846949163991667 0.950399550049808 GO:0005310 dicarboxylic acid transmembrane transporter activity 1/1109 31/18639 0.032258064516129 0.542162366560982 0.850908688061123 0.950399550049808 GO:0008327 methyl-CpG binding 1/1109 31/18639 0.032258064516129 0.542162366560982 0.850908688061123 0.950399550049808 GO:0016411 acylglycerol O-acyltransferase activity 1/1109 31/18639 0.032258064516129 0.542162366560982 0.850908688061123 0.950399550049808 GO:0016878 acid-thiol ligase activity 1/1109 31/18639 0.032258064516129 0.542162366560982 0.850908688061123 0.950399550049808 GO:0017147 Wnt-protein binding 1/1109 31/18639 0.032258064516129 0.542162366560982 0.850908688061123 0.950399550049808 GO:0070325 lipoprotein particle receptor binding 1/1109 31/18639 0.032258064516129 0.542162366560982 0.850908688061123 0.950399550049808 GO:0072349 modified amino acid transmembrane transporter activity 1/1109 31/18639 0.032258064516129 0.542162366560982 0.850908688061123 0.950399550049808 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 2/1109 56/18639 0.0357142857142857 0.600251191549659 0.854042022857649 0.952921888208996 GO:0008378 galactosyltransferase activity 1/1109 32/18639 0.03125 0.525219792605951 0.859794235403137 0.953478536002054 GO:0030515 snoRNA binding 1/1109 32/18639 0.03125 0.525219792605951 0.859794235403137 0.953478536002054 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1/1109 32/18639 0.03125 0.525219792605951 0.859794235403137 0.953478536002054 GO:0051059 NF-kappaB binding 1/1109 32/18639 0.03125 0.525219792605951 0.859794235403137 0.953478536002054 GO:0070717 poly-purine tract binding 1/1109 32/18639 0.03125 0.525219792605951 0.859794235403137 0.953478536002054 GO:0140142 nucleocytoplasmic carrier activity 1/1109 32/18639 0.03125 0.525219792605951 0.859794235403137 0.953478536002054 GO:0061980 regulatory RNA binding 2/1109 58/18639 0.0344827586206897 0.57955287459967 0.867334698538968 0.959564534544404 GO:0015276 ligand-gated monoatomic ion channel activity 8/1109 186/18639 0.043010752688172 0.722883155414643 0.870099459440988 0.959564534544404 GO:0036002 pre-mRNA binding 2/1109 59/18639 0.0338983050847458 0.56972994452171 0.873555707232689 0.959564534544404 GO:0070888 E-box binding 2/1109 59/18639 0.0338983050847458 0.56972994452171 0.873555707232689 0.959564534544404 GO:0033218 amide binding 11/1109 247/18639 0.0445344129554656 0.748491364361518 0.87529809093011 0.959564534544404 GO:0015020 glucuronosyltransferase activity 1/1109 34/18639 0.0294117647058824 0.494324510687954 0.876009474713825 0.959564534544404 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 1/1109 34/18639 0.0294117647058824 0.494324510687954 0.876009474713825 0.959564534544404 GO:0030332 cyclin binding 1/1109 34/18639 0.0294117647058824 0.494324510687954 0.876009474713825 0.959564534544404 GO:0051427 hormone receptor binding 1/1109 34/18639 0.0294117647058824 0.494324510687954 0.876009474713825 0.959564534544404 GO:0052866 phosphatidylinositol phosphate phosphatase activity 1/1109 34/18639 0.0294117647058824 0.494324510687954 0.876009474713825 0.959564534544404 GO:0090482 vitamin transmembrane transporter activity 1/1109 34/18639 0.0294117647058824 0.494324510687954 0.876009474713825 0.959564534544404 GO:0022834 ligand-gated channel activity 8/1109 188/18639 0.0425531914893617 0.715192909080444 0.877301826169959 0.959564534544404 GO:0005254 chloride channel activity 3/1109 83/18639 0.036144578313253 0.607483133616522 0.878369886967654 0.959564534544404 GO:0042277 peptide binding 11/1109 249/18639 0.0441767068273092 0.742479385531305 0.881445113307174 0.959564534544404 GO:0004497 monooxygenase activity 4/1109 106/18639 0.0377358490566038 0.634227674090205 0.882465476577625 0.959564534544404 GO:0000175 3'-5'-RNA exonuclease activity 1/1109 35/18639 0.0285714285714286 0.480200953239727 0.883400256360821 0.959564534544404 GO:0016229 steroid dehydrogenase activity 1/1109 35/18639 0.0285714285714286 0.480200953239727 0.883400256360821 0.959564534544404 GO:0043015 gamma-tubulin binding 1/1109 35/18639 0.0285714285714286 0.480200953239727 0.883400256360821 0.959564534544404 GO:0140566 histone reader activity 1/1109 35/18639 0.0285714285714286 0.480200953239727 0.883400256360821 0.959564534544404 GO:0000287 magnesium ion binding 10/1109 230/18639 0.0434782608695652 0.730740581016976 0.883814621569067 0.959564534544404 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 5/1109 128/18639 0.0390625 0.656524740757439 0.884539811819111 0.959564534544404 GO:0140098 catalytic activity, acting on RNA 18/1109 387/18639 0.0465116279069767 0.78172248201816 0.888161563762625 0.959564534544404 GO:0004190 aspartic-type endopeptidase activity 1/1109 36/18639 0.0277777777777778 0.466862037871957 0.890350864600761 0.959564534544404 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 1/1109 36/18639 0.0277777777777778 0.466862037871957 0.890350864600761 0.959564534544404 GO:0005484 SNAP receptor activity 1/1109 36/18639 0.0277777777777778 0.466862037871957 0.890350864600761 0.959564534544404 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 1/1109 36/18639 0.0277777777777778 0.466862037871957 0.890350864600761 0.959564534544404 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 1/1109 36/18639 0.0277777777777778 0.466862037871957 0.890350864600761 0.959564534544404 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 1/1109 36/18639 0.0277777777777778 0.466862037871957 0.890350864600761 0.959564534544404 GO:0046982 protein heterodimerization activity 17/1109 369/18639 0.046070460704607 0.774307770129099 0.890835394329103 0.959564534544404 GO:0022829 wide pore channel activity 1/1109 37/18639 0.027027027027027 0.454244144956498 0.896887492626228 0.962235686279554 GO:0030280 structural constituent of skin epidermis 1/1109 37/18639 0.027027027027027 0.454244144956498 0.896887492626228 0.962235686279554 GO:0042805 actinin binding 1/1109 37/18639 0.027027027027027 0.454244144956498 0.896887492626228 0.962235686279554 GO:0004222 metalloendopeptidase activity 4/1109 110/18639 0.0363636363636364 0.611164849577834 0.89905310294991 0.962235686279554 GO:0005179 hormone activity 5/1109 132/18639 0.0378787878787879 0.636630051643577 0.89965298303797 0.962235686279554 GO:0046873 metal ion transmembrane transporter activity 21/1109 450/18639 0.0466666666666667 0.784328223624887 0.900826570660559 0.962235686279554 GO:0022832 voltage-gated channel activity 7/1109 175/18639 0.04 0.672281334535618 0.901938508152272 0.962235686279554 GO:0005501 retinoid binding 1/1109 38/18639 0.0263157894736842 0.44229035166817 0.903034776288066 0.962235686279554 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 1/1109 38/18639 0.0263157894736842 0.44229035166817 0.903034776288066 0.962235686279554 GO:0019840 isoprenoid binding 1/1109 38/18639 0.0263157894736842 0.44229035166817 0.903034776288066 0.962235686279554 GO:0043531 ADP binding 1/1109 38/18639 0.0263157894736842 0.44229035166817 0.903034776288066 0.962235686279554 GO:0000217 DNA secondary structure binding 1/1109 39/18639 0.0256410256410256 0.430949573420268 0.908815886609906 0.966504395037292 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 1/1109 39/18639 0.0256410256410256 0.430949573420268 0.908815886609906 0.966504395037292 GO:0004177 aminopeptidase activity 1/1109 40/18639 0.025 0.420175834084761 0.914252616811498 0.967797475567244 GO:0004532 RNA exonuclease activity 1/1109 40/18639 0.025 0.420175834084761 0.914252616811498 0.967797475567244 GO:0042054 histone methyltransferase activity 2/1109 67/18639 0.0298507462686567 0.501702488459416 0.914424529753088 0.967797475567244 GO:0140223 general transcription initiation factor activity 2/1109 68/18639 0.0294117647058824 0.494324510687954 0.918558336734259 0.967797475567244 GO:0001530 lipopolysaccharide binding 1/1109 41/18639 0.024390243902439 0.409927643009523 0.919365464166519 0.967797475567244 GO:0004812 aminoacyl-tRNA ligase activity 1/1109 41/18639 0.024390243902439 0.409927643009523 0.919365464166519 0.967797475567244 GO:0008227 G protein-coupled amine receptor activity 1/1109 41/18639 0.024390243902439 0.409927643009523 0.919365464166519 0.967797475567244 GO:0016875 ligase activity, forming carbon-oxygen bonds 1/1109 41/18639 0.024390243902439 0.409927643009523 0.919365464166519 0.967797475567244 GO:0016877 ligase activity, forming carbon-sulfur bonds 1/1109 41/18639 0.024390243902439 0.409927643009523 0.919365464166519 0.967797475567244 GO:0140828 metal cation:monoatomic cation antiporter activity 1/1109 41/18639 0.024390243902439 0.409927643009523 0.919365464166519 0.967797475567244 GO:0015079 potassium ion transmembrane transporter activity 6/1109 160/18639 0.0375 0.630263751127142 0.9198075181011 0.967797475567244 GO:0008168 methyltransferase activity 8/1109 204/18639 0.0392156862745098 0.659099347583939 0.923820058406838 0.970516072251016 GO:0016859 cis-trans isomerase activity 1/1109 42/18639 0.0238095238095238 0.400167461033106 0.924173707001197 0.970516072251016 GO:0008276 protein methyltransferase activity 3/1109 95/18639 0.0315789473684211 0.530748422001803 0.927222462103353 0.97277963509687 GO:0005216 monoatomic ion channel activity 20/1109 448/18639 0.0446428571428571 0.750313989437073 0.931037999916913 0.975382351292074 GO:0022843 voltage-gated monoatomic cation channel activity 5/1109 143/18639 0.034965034965035 0.587658509209456 0.932675537754198 0.975382351292074 GO:0030547 signaling receptor inhibitor activity 1/1109 44/18639 0.0227272727272727 0.381978030986146 0.93294782794319 0.975382351292074 GO:0005518 collagen binding 2/1109 72/18639 0.0277777777777778 0.466862037871957 0.933285959638513 0.975382351292074 GO:0008170 N-methyltransferase activity 3/1109 98/18639 0.0306122448979592 0.514501021328279 0.936230083949477 0.977332436439704 GO:0042605 peptide antigen binding 1/1109 45/18639 0.0222222222222222 0.373489630297565 0.936946798570294 0.977332436439704 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 1/1109 46/18639 0.0217391304347826 0.365370290508488 0.940707474077745 0.978758436861151 GO:0005267 potassium channel activity 4/1109 124/18639 0.032258064516129 0.542162366560982 0.941965834795392 0.978758436861151 GO:0061749 forked DNA-dependent helicase activity 1/1109 47/18639 0.0212765957446809 0.357596454540222 0.944244042208105 0.978758436861151 GO:0099095 ligand-gated monoatomic anion channel activity 1/1109 47/18639 0.0212765957446809 0.357596454540222 0.944244042208105 0.978758436861151 GO:1990518 single-stranded 3'-5' DNA helicase activity 1/1109 47/18639 0.0212765957446809 0.357596454540222 0.944244042208105 0.978758436861151 GO:0016741 transferase activity, transferring one-carbon groups 8/1109 215/18639 0.0372093023255814 0.625377985614528 0.946166486160741 0.978758436861151 GO:0008188 neuropeptide receptor activity 1/1109 48/18639 0.0208333333333333 0.350146528403968 0.94756984670419 0.978758436861151 GO:0009378 four-way junction helicase activity 1/1109 48/18639 0.0208333333333333 0.350146528403968 0.94756984670419 0.978758436861151 GO:0036121 double-stranded DNA helicase activity 1/1109 48/18639 0.0208333333333333 0.350146528403968 0.94756984670419 0.978758436861151 GO:0043138 3'-5' DNA helicase activity 1/1109 48/18639 0.0208333333333333 0.350146528403968 0.94756984670419 0.978758436861151 GO:0005261 monoatomic cation channel activity 14/1109 341/18639 0.0410557184750733 0.690024830168523 0.948200322211675 0.978758436861151 GO:0005244 voltage-gated monoatomic ion channel activity 6/1109 173/18639 0.0346820809248555 0.582902891215853 0.949125225617279 0.978785388917819 GO:0016763 pentosyltransferase activity 1/1109 49/18639 0.0204081632653061 0.343000680885519 0.950697437474189 0.979479195278517 GO:0005246 calcium channel regulator activity 1/1109 53/18639 0.0188679245283019 0.317113837045103 0.961451442513737 0.988821009516518 GO:0042393 histone binding 9/1109 247/18639 0.0364372469635627 0.612402025386696 0.961580761320471 0.988821009516518 GO:0003925 G protein activity 1/1109 54/18639 0.0185185185185185 0.311241358581304 0.963751579727353 0.990118368229328 GO:0070851 growth factor receptor binding 4/1109 139/18639 0.0287769784172662 0.48365563635656 0.968926683476889 0.993658556773018 GO:0022836 gated channel activity 12/1109 318/18639 0.0377358490566038 0.634227674090205 0.969022394208398 0.993658556773018 GO:0017116 single-stranded DNA helicase activity 1/1109 58/18639 0.0172413793103448 0.289776437299835 0.97166011599207 0.99536817464276 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 5/1109 167/18639 0.029940119760479 0.503204591718277 0.973431685945399 0.99536817464276 GO:0016874 ligase activity 5/1109 167/18639 0.029940119760479 0.503204591718277 0.973431685945399 0.99536817464276 GO:0061659 ubiquitin-like protein ligase activity 14/1109 372/18639 0.0376344086021505 0.632522760987812 0.978073270876551 0.998034650946862 GO:0042562 hormone binding 2/1109 94/18639 0.0212765957446809 0.357596454540222 0.97846882674967 0.998034650946862 GO:0008528 G protein-coupled peptide receptor activity 3/1109 122/18639 0.0245901639344262 0.413287705657142 0.978788803683423 0.998034650946862 GO:0004252 serine-type endopeptidase activity 5/1109 176/18639 0.0284090909090909 0.477472538732683 0.981586342676211 0.999155672164947 GO:0005249 voltage-gated potassium channel activity 2/1109 98/18639 0.0204081632653061 0.343000680885519 0.982558841803512 0.999155672164947 GO:0019783 ubiquitin-like protein peptidase activity 3/1109 127/18639 0.0236220472440945 0.397016536143081 0.98327612340205 0.999155672164947 GO:0001653 peptide receptor activity 3/1109 128/18639 0.0234375 0.393914844454463 0.984057336738651 0.999155672164947 GO:0004175 endopeptidase activity 15/1109 405/18639 0.037037037037037 0.622482717162609 0.984475699020191 0.999155672164947 GO:0140299 molecular sensor activity 1/1109 71/18639 0.0140845070422535 0.236718779766063 0.987269710283617 0.999999968285547 GO:0008234 cysteine-type peptidase activity 5/1109 187/18639 0.0267379679144385 0.449385918807231 0.988371426156873 0.999999968285547 GO:0061630 ubiquitin protein ligase activity 12/1109 353/18639 0.0339943342776204 0.571343910370213 0.989591600333509 0.999999968285547 GO:0140101 catalytic activity, acting on a tRNA 3/1109 139/18639 0.0215827338129496 0.36274172726742 0.99063830039435 0.999999968285547 GO:0008236 serine-type peptidase activity 5/1109 194/18639 0.0257731958762887 0.43317096297398 0.991373044323915 0.999999968285547 GO:0017171 serine hydrolase activity 5/1109 198/18639 0.0252525252525253 0.424420034429052 0.992740675537579 0.999999968285547 GO:0101005 deubiquitinase activity 2/1109 115/18639 0.0173913043478261 0.29229623240679 0.992971060640347 0.999999968285547 GO:0003730 mRNA 3'-UTR binding 7/1109 262/18639 0.0267175572519084 0.449042876121119 0.995880674142303 0.999999968285547 GO:0019787 ubiquitin-like protein transferase activity 16/1109 479/18639 0.0334029227557411 0.561404037190495 0.996893731785378 0.999999968285547 GO:0004842 ubiquitin-protein transferase activity 14/1109 449/18639 0.0311804008908686 0.524050038056718 0.998118243516287 0.999999968285547 GO:0016755 aminoacyltransferase activity 16/1109 496/18639 0.032258064516129 0.542162366560982 0.99821733364775 0.999999968285547 GO:0003823 antigen binding 3/1109 174/18639 0.0172413793103448 0.289776437299835 0.998383809277064 0.999999968285547 GO:0004843 cysteine-type deubiquitinase activity 1/1109 108/18639 0.00925925925925926 0.155620679290652 0.998699069010049 0.999999968285547 GO:0008083 growth factor activity 2/1109 162/18639 0.0123456790123457 0.207494239054203 0.999475651037154 0.999999968285547 GO:0045182 translation regulator activity 4/1109 356/18639 0.0112359550561798 0.188843071498769 0.999999395855715 0.999999968285547 GO:0030371 translation repressor activity 2/1109 329/18639 0.0060790273556231 0.102170415582921 0.999999968285547 0.999999968285547