category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	45/512	222/9376	3.71199324324324	MRPL18/RPS3/RPLP2/RPL8/RPL13A/RPS25/RPL27A/RPS16/RPS6/RPL9/RPS2/RPS15/RPS20/RPL10/RPL7A/RPL41/RPL6/RPS14/RPS13/RPSA/RPL3/RPL19/RPS12/UBA52/RACK1/RPL31/RPL23A/RPS10/RPS4X/RPS27A/RPL18/RPS11/RPL27/RPL38/RPS5/MRPS34/MRPL3/RPL5/RPS8/RPS26/MRPS23/RPL4/MRPS35/RPL22L1/MRPS18C	9.82800528512148
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	45/512	238/9376	3.4624474789916	RPS3/RPLP2/RPL8/RPL13A/RPS25/RPL27A/RPS16/RPS6/RPL9/JUN/RPS2/RPS15/RPS20/RPL10/RPL7A/RPL41/RPL6/RPS14/RPS13/RPSA/RPL3/RPL19/RPS12/UBA52/RPL31/RPL23A/RPS10/RPS4X/RPS27A/FOS/RPL18/RPS11/RPL27/RPL38/RPS5/IL6R/RPL5/CGAS/RPS8/C3AR1/IRAK4/RPS26/RPL4/RPL22L1/HBEGF	9.24774025320374
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	48/512	368/9376	2.38858695652174	MT-ATP6/MT-ATP8/MT-ND4/MT-CYB/MT-ND1/MT-ND2/MT-CO2/MT-ND5/MT-CO1/MT-ND4L/SRSF3/TUBA1B/TUBB4B/ACTG1/TUBA1C/DNAH12/COX6B1/C9orf72/GPX3/DNAH7/DNAH11/ACTB/HNRNPA1/DDIT3/ATF4/ATP5PD/SOD1/NDUFA4/MAP2K6/COX8A/NUP210L/DNAH5/XBP1/COX6A1/RAC1/ATP5PF/HNRNPA2B1/PFN1/ATP5F1D/NDUFC2/NDUFB3/ERBB4/ADRM1/TUBB/NDUFA3/NDUFB4/ANG/DNAI1	6.53113328897651
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	39/512	275/9376	2.59704545454545	MT-ATP6/HSPA1B/MT-ATP8/MT-ND4/MT-CYB/HSPA1A/MT-ND1/MT-ND2/MT-CO2/MT-ND5/MT-CO1/MT-ND4L/TUBA1B/TUBB4B/HSPA8/HSPA6/TUBA1C/STIP1/COX6B1/NCF1/HSPA1L/DDIT3/ATF4/ATP5PD/SOD1/NDUFA4/COX8A/COX6A1/RAC1/ATP5PF/ATP5F1D/NDUFC2/NDUFB3/CYBA/RAC2/ADRM1/TUBB/NDUFA3/NDUFB4	6.46018286891856
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	32/512	200/9376	2.93	RPS3/CLDN4/TUBA1B/TUBB4B/ACTG1/GAPDH/CLDN3/JUN/TUBA1C/ARPC1B/FOS/TJP1/TRADD/ACTB/ARPC5L/NCL/PTPN6/ARPC5/RAC1/TMBIM6/NCKAP1/IRAK4/ARHGEF12/BAIAP2/MYO6/MYO1E/MYO1D/MYH11/TUBB/MYO5C/MYO10/TNFSF10	6.6305774055468
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	32/512	205/9376	2.85853658536585	MT-ATP6/MT-ATP8/MT-ND4/MT-CYB/MT-ND1/MT-ND2/MT-CO2/MT-ND5/MT-CO1/MT-ND4L/COL1A2/GAPDH/PDK4/PLCB1/COX6B1/NCF1/ATP5PD/NDUFA4/COX8A/COX6A1/RAC1/ATP5PF/ATP5F1D/NDUFC2/TGFBR1/NDUFB3/PLCB4/CYBA/RAC2/AKT3/NDUFA3/NDUFB4	6.46614506258892
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	34/512	227/9376	2.74284140969163	MT-ATP6/MT-ATP8/MT-ND4/MT-CYB/MT-ND1/MT-ND2/MT-CO2/MT-ND5/MT-CO1/MT-ND4L/SLC26A2/MGST1/JUN/MET/COX6B1/FOS/NCF1/ATP5PD/SOD1/NDUFA4/COX8A/MGST3/COX6A1/GSTM4/RAC1/ATP5PF/ATP5F1D/NDUFC2/NDUFB3/CYBA/AKT3/NDUFA3/SOD2/NDUFB4	6.38836512239211
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	37/512	268/9376	2.52821828358209	MT-ATP6/MT-ATP8/MT-ND4/MT-CYB/MT-ND1/MT-ND2/MT-CO2/MT-ND5/MT-CO1/MT-ND4L/TUBA1B/TUBB4B/TUBA1C/UBB/COX6B1/UBA52/RPS27A/DUSP1/DDIT3/ATF4/ATP5PD/SOD1/NDUFA4/COX8A/MAOA/XBP1/COX6A1/ATP5PF/SLC18A2/ATP5F1D/NDUFC2/SLC39A14/NDUFB3/ADRM1/TUBB/NDUFA3/NDUFB4	6.10024141361124
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	24/512	138/9376	3.18478260869565	MT-ATP6/MT-ATP8/MT-ND4/MT-CYB/MT-ND1/MT-ND2/MT-CO2/MT-ND5/MT-CO1/MT-ND4L/COX6B1/ATP6V1C2/ATP5PD/NDUFA4/ATP5MF/COX8A/COX6A1/ATP5PF/ATP5F1D/NDUFC2/NDUFB3/NDUFA3/ATP6V1F/NDUFB4	6.21390399797135
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	39/512	308/9376	2.31879058441558	MT-ATP6/MT-ATP8/MT-ND4/MT-CYB/MT-ND1/MT-ND2/MT-CO2/MT-ND5/MT-CO1/MT-ND4L/TUBA1B/TUBB4B/TUBA1C/DNAH12/PLCB1/COX6B1/GPX3/DNAH7/DNAH11/CLTA/ATP5PD/SOD1/NDUFA4/COX8A/DNAH5/COX6A1/ATP5PF/ATP5F1D/NDUFC2/NDUFB3/PLCB4/ADRM1/TUBB/POLR2J/NDUFA3/SOD2/NDUFB4/TFAM/DNAI1	5.6558930076213
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	32/512	248/9376	2.36290322580645	HSP90AA1/HSP90AB1/RPS3/TUBA1B/TUBB4B/ACTG1/GAPDH/JUN/TUBA1C/ANXA2/RHOB/MYL12A/ARPC1B/FOS/S100A10/TRADD/DYNLL1/ACTB/DYNLRB1/ARPC5L/DYNLT3/MAP2K6/ARPC5/RAC1/NCKAP1/PFN1/IRAK4/MYO6/AKT3/TUBB/TNFSF10/STX10	5.2276775171754
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	29/512	216/9376	2.45862268518519	HSPA1B/HSPA1A/HSP90AA1/HSP90AB1/HSPA8/HSPD1/JUN/HSPA4/HSPA6/CD40LG/PLCB1/FOS/NCF1/HSPA2/CCL3L1/HSPA1L/DDIT3/ATF4/MAP2K6/POU2F2/XBP1/RAC1/IRAK4/PLCB4/CYBA/VCAM1/AKT3/SOD2/TNFSF10	5.21228131668989
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	22/512	142/9376	2.83714788732394	HSP90AA1/HSP90AB1/ACTG1/MGST1/JUN/FOS/NCF1/ACTB/DUSP1/KLF2/CTSL/MAP2K6/MGST3/GSTM4/RAC1/SDC2/CYBA/RAC2/PLAT/VCAM1/AKT3/ACVR2A	5.30150407751817
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	17/512	93/9376	3.34744623655914	ACTG1/PTPRM/MET/MYL12A/TJP1/ACTB/CDH1/PTPN6/RAC1/WAS/SNAI1/TGFBR1/BAIAP2/RAC2/CTNND1/AFDN/CTNNA1	5.46762472147917
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	24/512	174/9376	2.52586206896552	HSPA1B/HSPA1A/HSP90AA1/HSPH1/HSP90AB1/DNAJB1/DNAJA1/HSPA8/ERP29/HSPA6/UBE2D2/HSPA1L/CRYAB/DDIT3/ATF4/HERPUD1/DAD1/XBP1/P4HB/SSR4/UBXN1/KRTCAP2/PPP1R15A/SSR2	4.88263805656228
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	21/512	157/9376	2.44944267515924	MT-CYB/MT-CO2/MT-CO1/JUN/COX6B1/FOS/IL6R/DDIT3/ATF4/NDUFA4/LEPR/COX8A/XBP1/COX6A1/RAC1/NDUFC2/SOCS3/NDUFB3/AKT3/NDUFA3/NDUFB4	4.4016419039577
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	22/512	170/9376	2.36985294117647	CLDN4/TUBA1B/ACTG1/CLDN3/JUN/HSPA4/TUBA1C/MYL12A/ARPC1B/TJP1/ACTB/ARPC5L/MAGI1/ARPC5/RAC1/WAS/F11R/MYH11/PATJ/TJP2/AFDN/TJP3	4.33180269278762
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	19/512	139/9376	2.50314748201439	HSPA1B/HSPA1A/HSP90AA1/HSP90AB1/KRT19/HSPA8/KRT18/JUN/HSPA6/PLCB1/FOS/KRT23/KRT10/HSPA1L/ATF4/PLCB4/AKT3/FKBP4/HBEGF	4.29090863165764
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	27/512	235/9376	2.10398936170213	MT-ATP6/MT-ATP8/MT-ND4/MT-CYB/MT-ND1/MT-ND2/MT-CO2/MT-ND5/MT-CO1/MT-ND4L/ACTG1/RPS6/SLC25A29/COX6B1/ACTB/NDUFAF3/ATP5PD/NDUFA4/ATP5MF/COX8A/COX6A1/ATP5PF/ATP5F1D/NDUFC2/NDUFB3/NDUFA3/NDUFB4	4.11915097608604
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	45/512	480/9376	1.716796875	MT-ATP6/MT-ATP8/MT-ND4/MT-CYB/MT-ND1/MT-ND2/MT-CO2/MT-ND5/MT-CO1/MT-ND4L/TUBA1B/TUBB4B/TUBA1C/UBB/DNAH12/PLCB1/COX6B1/C9orf72/UBA52/GPX3/DNAH7/RPS27A/DNAH11/DDIT3/ATF4/ATP5PD/SOD1/NDUFA4/MAP2K6/COX8A/DNAH5/XBP1/COX6A1/RAC1/ATP5PF/ATP5F1D/NDUFC2/NDUFB3/PPID/PLCB4/ADRM1/TUBB/NDUFA3/NDUFB4/DNAI1	3.87458399210638
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	38/512	388/9376	1.79349226804124	MT-ATP6/MT-ATP8/MT-ND4/MT-CYB/MT-ND1/MT-ND2/MT-CO2/MT-ND5/MT-CO1/MT-ND4L/TUBA1B/TUBB4B/GAPDH/TUBA1C/PLCB1/COX6B1/BACE2/DDIT3/ATF4/ATP5PD/NDUFA4/COX8A/XBP1/COX6A1/ATP5PF/PSENEN/ATP5F1D/NDUFC2/SLC39A14/NDUFB3/PPID/PLCB4/AKT3/ADRM1/TUBB/NDUFA3/ADAM10/NDUFB4	3.83647855704195
Organismal Systems	Digestive system	hsa04978	Mineral absorption	11/512	61/9376	3.30225409836066	MT1G/MT1F/SLC34A2/MT1X/MT1M/MT2A/SLC40A1/MT1E/MT1H/FTL/SLC26A3	4.33543308619909
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	31/512	300/9376	1.89229166666667	HSPA1B/HSPA1A/MECOM/HSPA8/HSPB1/GADD45B/JUN/HSPA6/MET/NR4A1/FOS/TRADD/DUSP1/HSPA1L/EFNA1/FLT3LG/DDIT3/ATF4/MAP2K6/VEGFB/RAC1/RASGRF2/IRAK4/TGFBR1/FGFR2/ERBB3/RAC2/AKT3/RPS6KA5/ERBB4/MAPKAPK3	3.77507831636653
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	18/512	138/9376	2.38858695652174	ACTG1/JUN/ARPC1B/LAT/FOS/ACTB/ARPC5L/CD4/MAP2K6/ARPC5/RAC1/WAS/IRAK4/ARHGEF12/ZAP70/BAIAP2/RAC2/AKT3	3.94938425741712
Cellular Processes	Cell motility	hsa04814	Motor proteins	22/512	194/9376	2.07667525773196	TUBA1B/TUBB4B/ACTG1/TUBA1C/DNAH12/MYL12A/DNAH7/DYNLL1/DNAH11/ACTB/DYNLRB1/DYNLT3/DNAH5/KIF9/MYO6/MYO1E/MYO1D/MYH11/TUBB/MYO5C/MYO10/DNAI1	3.64185540497937
NA	NA	hsa04519	Cadherin signaling	37/512	404/9376	1.6771349009901	KRT19/KRT8/GABRP/ACTG1/KRT18/DSP/LIMA1/MET/ARPC1B/PCDH7/YWHAH/JUP/TJP1/KRT23/KRT10/KRT7/ACTB/ARPC5L/DSG2/WWC1/CDH1/VIM/ARPC5/RAC1/DSC2/NCKAP1/PSENEN/YAP1/MYO1E/RAC2/MYO1D/TMC4/CTNND1/ADAM10/AFDN/CTNNA1/CDH26	3.3436976036268
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	12/512	82/9376	2.67987804878049	HSPA1B/HSPA1A/HSP90AA1/HSP90AB1/HLA-B/HSPA8/HSPA4/HSPA6/HSPA2/HSPA1L/CD4/CTSL	3.67188517933093
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	15/512	116/9376	2.36799568965517	CLDN4/ACTG1/CLDN3/MYL12A/NCF1/ACTB/ARHGAP5/RAC1/F11R/CYBA/RAC2/VCAM1/CTNND1/AFDN/CTNNA1	3.56298484628478
NA	NA	hsa04517	IgSF CAM signaling	29/512	299/9376	1.77612876254181	TUBA1B/TUBB4B/ACTG1/CD2/GRIP1/TUBA1C/MYL12A/ARPC1B/TJP1/DYNLL1/ACTB/ARPC5L/SLIT2/DOK2/CDH1/PTPN6/MAGI1/ARPC5/RAC1/ICAM2/BAIAP2/ICAM3/F11R/AKT3/MYH11/TJP2/TUBB/AFDN/SLAMF1	3.2779622642173
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	14/512	109/9376	2.35206422018349	HSP90AA1/HSP90AB1/CD3E/CD3D/JUN/LAT/FOS/CD3G/CD4/IL6R/IFNGR1/IL23A/TGFBR1/ZAP70	3.41229627943551
Human Diseases	Infectious disease: viral	hsa05162	Measles	16/512	136/9376	2.15441176470588	HSPA1B/HSPA1A/HSPA8/CD3E/CD3D/JUN/HSPA6/RACK1/FOS/CD3G/TRADD/HSPA1L/CCND3/IRAK4/AKT3/SLAMF1	3.25911704502121
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	11/512	78/9376	2.58253205128205	ACTG1/MET/SEPTIN1/ARPC1B/ACTB/ARPC5L/CLTA/CDH1/ARPC5/RAC1/CTNNA1	3.37295688656051
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	12/512	90/9376	2.44166666666667	CD3E/CD3D/JUN/LAT/FOS/CD3G/CD4/MAP2K6/IFNGR1/PTPN6/ZAP70/AKT3	3.30276380968577
NA	NA	hsa04518	Integrin signaling	17/512	154/9376	2.02150974025974	SPP1/ACTG1/COL1A2/MET/FREM2/ACTB/ITGB8/CDH1/VEGFB/RAC1/CCND3/ICAM2/ICAM3/LAMA5/RAC2/VCAM1/AKT3	3.07182208555815
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	21/512	212/9376	1.81397405660377	ID1/ACTG1/MET/PLCB1/MAGI3/LAT/ACTB/EFNA1/CDH1/MAP2K6/MAGI1/VEGFB/RAC1/PFN1/RGS14/PLCB4/FGFR2/RAC2/AKT3/CTNND1/AFDN	2.88098965120963
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	9/512	62/9376	2.65826612903226	HSPA1B/HSPA1A/HSPA8/HSPA6/HSPA1L/CRYAB/SOD1/AKT3/SOD2	3.14838404654776
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	12/512	98/9376	2.24234693877551	ARPC1B/LAT/NCF1/CFL1/ARPC5L/ARPC5/RAC1/WAS/PLPP2/RAC2/AKT3/MYO10	2.97121783260403
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	7/512	42/9376	3.05208333333333	CP/SAT1/SLC40A1/FTL/SLC3A2/GPX4/SLC39A14	3.20325479589326
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	13/512	112/9376	2.12555803571429	HSPA1B/HSPA1A/HSPA8/HSPA6/CD40LG/SOCS1/HSPA1L/MAP2K6/IFNGR1/IRGM/IRAK4/LAMA5/AKT3	2.87993957667338
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	12/512	100/9376	2.1975	CD24/CD3E/CD3D/CD2/CD37/CD3G/CD9/IL7R/CD4/IL6R/FLT3LG/CD59	2.89334950002503
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	12/512	103/9376	2.13349514563107	CD3E/CD3D/JUN/PLCB1/FOS/CD3G/CCL3L1/IFNGR1/IRAK4/TGFBR1/PLCB4/AKT3	2.77993020279643
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	8/512	56/9376	2.61607142857143	HSPA1B/HSPA1A/HSPA8/HSPD1/HSPA6/EEF1G/EEF1A1/HSPA1L	2.91509259685831
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	23/512	253/9376	1.66477272727273	ACTG1/JUN/UBB/TIFA/PLCB1/UBA52/UBE2D2/MYL12A/ARPC1B/RPS27A/TRADD/ACTB/ARPC5L/FNBP1L/ARPC5/RAC1/CGAS/PFN1/PPID/PLCB4/AKT3/RPS6KA5/CAST	2.57614534499305
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	14/512	133/9376	1.92763157894737	SGK1/GADD45B/DEPP1/HOMER2/HOMER1/IL7R/KLF2/PLK2/BCL6/TGFBR1/S1PR4/AKT3/SOD2/TNFSF10	2.5894087646509
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	16/512	160/9376	1.83125	HLA-B/CLDN4/PTPRM/CLDN3/CD2/CD40LG/CD4/ITGB8/ALCAM/CDH1/NRXN3/SDC2/ICAM2/ICAM3/F11R/VCAM1	2.54874367828205
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	6/512	37/9376	2.96959459459459	HBA1/PLCB1/HBA2/IDO2/PLCB4/VCAM1	2.88491660243077
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	9/512	71/9376	2.32130281690141	JUN/MET/TJP1/ATP6V1C2/RAC1/F11R/ATP6V1F/ADAM10/HBEGF	2.68583353138945
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	15/512	149/9376	1.84354026845638	MT-ND4/MT-ND1/MT-ND2/MT-ND5/MT-ND4L/GABRP/PLCB1/NDUFA4/GNG5/NDUFC2/NDUFB3/PLCB4/GNG11/NDUFA3/NDUFB4	2.49444790515013
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	6/512	38/9376	2.89144736842105	CD3E/CD3D/CD40LG/IL7R/CD4/ZAP70	2.80779159452268
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	14/512	137/9376	1.8713503649635	TUBA1B/ACTG1/GADD45B/JUN/TUBA1C/FOS/TRADD/ACTB/DDIT3/ATF4/CTSL/AKT3/PARP4/TNFSF10	2.46914368055921
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	11/512	100/9376	2.014375	CXCL14/CCL20/CCL3L1/IL6R/CCL18/CCR2/CX3CR1/IL20RA/TNFRSF10D/IL18R1/TNFSF10	2.45089052115899
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	25/512	298/9376	1.53628355704698	CXCL14/IL32/CD40LG/CCL20/CCL3L1/IL7R/CD4/IL6R/CCL18/LEPR/IFNGR1/CD27/CCR2/CX3CR1/IL23A/IL20RA/TGFBR1/TNFRSF10D/EDA/ACVR2A/GDF11/IL18R1/OSM/TNFSF10/IL16	2.26106615430106
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	29/512	362/9376	1.46702348066298	HSP90AA1/HSP90AB1/SPP1/COL1A2/SGK1/RPS6/MET/NR4A1/YWHAH/EIF4B/IL7R/EFNA1/DDIT4/IL6R/ITGB8/FLT3LG/ATF4/GNG5/MAGI1/VEGFB/RAC1/CCND3/FGFR2/ERBB3/LAMA5/AKT3/ERBB4/GNG11/OSM	2.17791020386375
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	12/512	119/9376	1.84663865546218	JUN/FOS/JUNB/CCL20/TRADD/ATF4/MAP2K6/SOCS3/VCAM1/AKT3/RPS6KA5/IL18R1	2.23378920196726
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	10/512	93/9376	1.96908602150538	CD3E/CD3D/JUN/LAT/FOS/CD3G/CD4/IFNGR1/ZAP70/MAML3	2.25717573672286
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	7/512	59/9376	2.17266949152542	MGST1/GSTK1/GPX3/GGT7/MGST3/GSTM4/GPX4	2.1715474808955
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	14/512	155/9376	1.65403225806452	HLA-B/TUBA1B/TUBB4B/ACTG1/CORO1A/TUBA1C/NCF1/ATP6V1C2/ACTB/CTSL/RAC1/CYBA/TUBB/ATP6V1F	1.97324836722615
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	9/512	86/9376	1.91642441860465	ACTG1/DSP/SGCD/JUP/ACTB/DSG2/ITGB8/DSC2/CTNNA1	2.05184129590363
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	18/512	214/9376	1.54030373831776	HLA-B/CD3E/CD3D/JUN/FOS/CD3G/TRADD/CFL1/CD4/MAP2K6/GNG5/RAC1/CGAS/IRAK4/RAC2/AKT3/GNG11/AP1M2	1.92156668397284
NA	NA	hsa03272	Virion - Hepatitis viruses	6/512	48/9376	2.2890625	CLDN4/SLC10A1/CLDN3/EPCAM/CD9/CHMP1B	2.15182064319355
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	13/512	142/9376	1.67649647887324	JUN/SOCS1/FOS/NCF1/JUNB/MAP2K6/IFNGR1/RAC1/LILRB1/TGFBR1/SOCS3/CYBA/AKT3	1.95218298206647
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	10/512	101/9376	1.81311881188119	COL1A2/JUN/PLCB1/PIM1/VEGFB/RAC1/TGFBR1/PLCB4/VCAM1/AKT3	1.97452884044334
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	12/512	130/9376	1.69038461538462	RXFP1/COL1A2/JUN/PLCB1/FOS/ATF4/GNG5/VEGFB/TGFBR1/PLCB4/AKT3/GNG11	1.9049850929254
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	6/512	50/9376	2.1975	CKB/ARG2/SAT1/MAOA/P4HA1/AZIN2	2.04041526370138
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	6/512	50/9376	2.1975	HBA1/CD40LG/MET/HBA2/SDC2/VCAM1	2.04041526370138
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	6/512	51/9376	2.15441176470588	ACTG1/TJP1/ATP6V1C2/ACTB/TJP2/ATP6V1F	1.98667651013723
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	8/512	78/9376	1.87820512820513	JUN/EEF1A1/FOS/NCF1/IFNGR1/PTPN6/IRAK4/CYBA	1.87177759375712
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	11/512	122/9376	1.65112704918033	CD3E/CD3D/JUN/CD40LG/LAT/FOS/CD3G/CD4/PTPN6/ZAP70/AKT3	1.7397492180735
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	14/512	168/9376	1.52604166666667	CISH/SOCS1/PIM1/IL7R/IL6R/LEPR/IFNGR1/PTPN6/CCND3/IL23A/IL20RA/SOCS3/AKT3/OSM	1.65347592409101
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	12/512	140/9376	1.56964285714286	SPP1/RPS6/PLCB1/KLF2/CDH1/GNG5/TGFBR1/PLCB4/PLAT/AKT3/GNG11/TFAM	1.6320387148068
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	7/512	70/9376	1.83125	HLA-B/ACTG1/SGCD/CD40LG/ACTB/RAC1/RAC2	1.67766366721898
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	5/512	44/9376	2.08096590909091	MGAT4A/B4GALNT3/DAD1/KRTCAP2/CHST9	1.72725602319185
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	9/512	99/9376	1.66477272727273	DGKH/JUN/FOS/SLC44A1/RAC1/WAS/PLPP2/RAC2/AKT3	1.5980588108407
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	8/512	85/9376	1.72352941176471	ENPP3/DCTPP1/GDA/NT5C3B/UPP1/APRT/AK4/GUK1	1.6104237541368
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	15/512	193/9376	1.42325129533679	CXCL14/PLCB1/NCF1/CCL20/CCL3L1/CCL18/GNG5/RAC1/WAS/CCR2/CX3CR1/PLCB4/RAC2/AKT3/GNG11	1.42787570179901
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	10/512	122/9376	1.50102459016393	PLCB1/SOCS1/FOS/JUNB/ATF4/IGFBP3/MAP2K6/SOCS3/PLCB4/AKT3	1.33868979958763
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	4/512	36/9376	2.03472222222222	ST6GALNAC1/GALNT4/C1GALT1C1/GCNT3	1.49488344924388
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	17/512	232/9376	1.34186422413793	ACTG1/MYL12A/ARPC1B/CFL1/ACTB/ARPC5L/ITGB8/ARPC5/RAC1/NCKAP1/PFN1/ARHGEF12/BAIAP2/FGFR2/RAC2/AKT3/MYH11	1.26717116933779
NA	NA	hsa04382	Cornified envelope formation	16/512	217/9376	1.35023041474654	KRT19/CLDN4/S100A11/KRT8/KRT18/DSP/CLDN3/S100A10/JUP/TJP1/KRT23/KRT10/KRT7/DSG2/LAMA5/ABHD5	1.25448490774799
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	17/512	233/9376	1.33610515021459	ACTG1/COL1A2/DSP/SGCD/JUP/ACTB/DSG2/PDLIM2/COL27A1/ITGB8/VIM/ENO1/DSC2/SDC2/NEBL/ENO2/MYH11	1.24857464942118
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	18/512	250/9376	1.3185	HSPA1B/HSPA1A/HLA-B/HSPA8/HSPA6/ARPC1B/ARPC5L/HSPA1L/CLTA/ARPC5/ACAP1/TGFBR1/CHMP2A/FGFR2/CHMP1B/WASHC3/VPS29/SNX3	1.22671860992414
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	4/512	37/9376	1.97972972972973	MIF/HGD/MAOA/LRTOMT	1.43503570275287
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	15/512	203/9376	1.35314039408867	SPP1/ACTG1/COL1A2/JUN/MET/MYL12A/ACTB/ITGB8/ARHGAP5/VEGFB/RAC1/CCND3/LAMA5/RAC2/AKT3	1.22249042015162
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	9/512	110/9376	1.49829545454545	GAPDH/RPS6/LDHA/TIMP1/IL6R/IFNGR1/ENO1/ENO2/AKT3	1.26340579675903
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	8/512	95/9376	1.54210526315789	JUN/FOS/ATP6V1C2/CCL20/CCL3L1/CTSL/IL23A/ATP6V1F	1.2763029852829
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	15/512	204/9376	1.34650735294118	ACTG1/COL1A2/RPS6/MET/EIF4B/ACTB/CTSL/PTPN6/RAC1/SDC2/ARHGEF12/ERBB3/AKT3/ERBB4/HBEGF	1.20254478844331
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	4/512	38/9376	1.92763157894737	SGK1/NR3C2/FXYD4/SCNN1A	1.37703866027025
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	12/512	158/9376	1.39082278481013	SGK1/RPS6/LAMTOR4/ATP6V1C2/DEPTOR/EIF4B/DDIT4/SLC3A2/AKT3/GRB10/ATP6V1F/LPIN3	1.19068206381716
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	7/512	83/9376	1.54442771084337	PMVK/GSTK1/SOD1/PHYH/PRDX1/ABCD2/SOD2	1.19731119953298
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	16/512	227/9376	1.29074889867841	HLA-B/PLCB1/TRADD/CCL3L1/IL6R/ATF4/MAP2K6/GNG5/RAC1/CGAS/PTGER2/ARHGEF12/PLCB4/RAC2/AKT3/GNG11	1.06573674079717
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	9/512	116/9376	1.4207974137931	HOMER2/PLCB1/HOMER1/SLC1A1/GNG5/PLCB4/SLC38A2/GNG11/SHANK2	1.09597919060591
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	4/512	41/9376	1.78658536585366	CDH1/DAPK1/RPS6KA5/HBEGF	1.21307143007548
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	10/512	133/9376	1.37687969924812	PLCB1/FOS/ATF4/MAOA/GNG5/SLC18A2/PLCB4/AKT3/GNG11/LRTOMT	1.05202929546607
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	7/512	87/9376	1.47341954022989	GADD45B/JUN/FOS/RAC1/TGFBR1/RAC2/AKT3	1.06617150008797
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	15/512	217/9376	1.26584101382489	HSP90AA1/HSP90AB1/UGT2B7/MGST1/PTGES3/JUN/FOS/ATF4/MGST3/PAQR8/BCL6/GSTM4/CCND3/AKT3/KLF5	0.952211817312001
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	6/512	73/9376	1.50513698630137	UGT2B7/MGST1/GSTK1/MGST3/MAOA/GSTM4	1.04127354204161
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	7/512	89/9376	1.44030898876405	TUBA1B/TUBB4B/TUBA1C/PLCB1/TJP1/PLCB4/TUBB	1.00304536882716
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	8/512	105/9376	1.3952380952381	GADD45B/CD40LG/LAT/TRADD/IRAK4/ZAP70/VCAM1/EDA	0.978804374475995
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	8/512	105/9376	1.3952380952381	JUN/UBB/UBA52/CITED2/RPS27A/FKBP8/ATF4/FIS1	0.978804374475995
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/512	16/9376	2.2890625	MIF/MAOA	1.24022872693266
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/512	16/9376	2.2890625	GLA/ST8SIA1	1.24022872693266
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	6/512	75/9376	1.465	PLCB1/GPX3/DUOX1/PAX8/ATF4/PLCB4	0.971682782439339
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	7/512	91/9376	1.40865384615385	JUN/FOS/PTPN6/RAC1/LILRB1/RAC2/AKT3	0.941436599156446
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	5/512	60/9376	1.52604166666667	HSPB1/RAC1/RAC2/AKT3/MAPKAPK3	0.982396429431641
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	14/512	205/9376	1.25060975609756	HLA-B/CD3E/CD3D/GADD45B/JUN/CD3G/TRADD/MAP2K6/VIM/RAC1/CCND3/IRAK4/AKT3/ADRM1	0.871911292888467
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/512	17/9376	2.15441176470588	PAPSS1/SEPHS2	1.14492285822496
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/512	17/9376	2.15441176470588	PCDH7/MYH11	1.14492285822496
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	11/512	157/9376	1.28304140127389	ID1/ACTG1/YWHAH/ACTB/WWC1/CDH1/CCND3/TGFBR1/YAP1/PATJ/CTNNA1	0.859535125985697
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	8/512	109/9376	1.34403669724771	SPP1/JUN/FOS/CCL3L1/MAP2K6/RAC1/IRAK4/AKT3	0.868268773393259
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	10/512	142/9376	1.28961267605634	UBB/UBA52/SOCS1/UBE2D2/ANAPC16/RPS27A/UBE2S/SOCS3/ANAPC13/MID1	0.835742616915898
Organismal Systems	Immune system	hsa04611	Platelet activation	9/512	126/9376	1.30803571428571	ACTG1/COL1A2/PLCB1/MYL12A/ACTB/VAMP8/ARHGEF12/PLCB4/AKT3	0.836606478976984
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	6/512	79/9376	1.39082278481013	ATP6V1C2/CLTA/SLC1A1/SLC18A2/STX3/ATP6V1F	0.83835459713044
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	6/512	80/9376	1.3734375	RPS6/MET/IL6R/FGFR2/ERBB3/AKT3	0.806158816416431
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	13/512	196/9376	1.21460459183673	HLA-B/JUN/UBB/UBA52/RPS27A/FOS/TRADD/MAP2K6/GNG5/IFNGR1/RAC1/AKT3/GNG11	0.729711936266445
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	4/512	49/9376	1.49489795918367	JUN/ATF4/MAOA/SLC18A2	0.834734684622178
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	5/512	65/9376	1.40865384615385	DGKH/LIPC/GLA/PLPP2/LPIN3	0.794547472986665
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	8/512	115/9376	1.27391304347826	SGK1/SLC34A2/PLCB1/FOS/RUNX2/ATF4/PLCB4/HBEGF	0.710294474944932
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	9/512	133/9376	1.23919172932331	HLA-B/LAT/IFNGR1/PTPN6/RAC1/ICAM2/ZAP70/RAC2/TNFSF10	0.667684428169863
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	5/512	67/9376	1.36660447761194	GAPDH/TPI1/LDHA/ENO1/ENO2	0.723751365656896
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	11/512	168/9376	1.19903273809524	HSP90AA1/HSP90AB1/PPIA/TRADD/FTL/IFNGR1/CHMP2A/PPID/CHMP1B/PYGL/TNFSF10	0.625607934504024
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	15/512	238/9376	1.15414915966387	MET/LAT/EFNA1/FLT3LG/GNG5/VEGFB/RAC1/RASGRF2/ZAP70/FGFR2/RAC2/AKT3/GNG11/PLAAT3/AFDN	0.578908342607507
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	5/512	69/9376	1.32699275362319	LAT/MAP2K6/RAC1/RAC2/AKT3	0.65518442057127
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	5/512	69/9376	1.32699275362319	JUN/FOS/ATF4/MAOA/SLC18A2	0.65518442057127
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	3/512	37/9376	1.4847972972973	GADD45B/PAX8/CDH1	0.71009525291392
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	7/512	103/9376	1.24453883495146	COL1A2/HSPB1/ARG2/PLCB1/PRDX1/PLCB4/LAMA5	0.599738689361328
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	5/512	70/9376	1.30803571428571	UGT2B7/MGST1/GSTK1/MGST3/GSTM4	0.621690617820138
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	6/512	87/9376	1.26293103448276	MT-CYB/MT-CO2/MT-CO1/COX6B1/COX8A/COX6A1	0.59213773752989
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	14/512	224/9376	1.14453125	HLA-B/CD3E/CD3D/JUN/ANAPC16/FOS/CD3G/MSX1/CD4/ATF4/CCND3/TGFBR1/ANAPC13/AKT3	0.526178995096102
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	3/512	38/9376	1.44572368421053	GNPDA1/GNPDA2/FPGT	0.66166219314404
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	5/512	71/9376	1.28961267605634	CISH/SOCS1/FOS/SOCS3/AKT3	0.58870035431521
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	7/512	106/9376	1.20931603773585	HSP90AA1/HSP90AB1/ATF4/SPINT1/FGFR2/PLAT/AKT3	0.520860370693872
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	2/512	23/9376	1.59239130434783	RPA2/SSBP1	0.683601285547708
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	4/512	56/9376	1.30803571428571	MGAT4A/DAD1/KRTCAP2/ST6GAL1	0.555639196638739
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	8/512	125/9376	1.172	PLCB1/TRADD/RAC1/ORMDL3/PLCB4/S1PR4/RAC2/AKT3	0.465259080373843
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	9/512	144/9376	1.14453125	ID1/ID3/DLX5/SMAD9/ID4/POU5F1/FGFR2/AKT3/ACVR2A	0.420049867346353
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	5/512	75/9376	1.22083333333333	GAPDH/ARG2/TPI1/ENO1/ENO2	0.461462253309005
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	5/512	75/9376	1.22083333333333	PERP/GADD45B/IGFBP3/CCND3/CD82	0.461462253309005
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	7/512	110/9376	1.16534090909091	ID1/ID3/SMAD9/ID4/EMP3/TGFBR1/ACVR2A	0.419214466199404
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	6/512	93/9376	1.18145161290323	JUN/PLCB1/ATF4/MAP2K6/PLCB4/HBEGF	0.42263345971926
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	5/512	76/9376	1.20476973684211	ACTG1/PLCB1/GAST/ACTB/PLCB4	0.430761458761764
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	4/512	59/9376	1.24152542372881	ENPP3/DCTPP1/NT5C3B/UPP1	0.447256391729155
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	4/512	59/9376	1.24152542372881	GADD45B/CDH1/AKT3/CTNNA1	0.447256391729155
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	6/512	94/9376	1.1688829787234	HSP90AA1/HSP90AB1/JUN/FOS/CCL20/TRADD	0.395489329143881
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	5/512	77/9376	1.18912337662338	GADD45B/RAC1/TGFBR1/RAC2/AKT3	0.400477569856359
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	5/512	78/9376	1.17387820512821	HSPD1/TOB1/EXOSC8/ENO1/ENO2	0.370598300953737
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	5/512	78/9376	1.17387820512821	JUN/FOS/CFL1/IL23A/IRAK4	0.370598300953737
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/512	10/9376	1.83125	PAPSS1	0.632062939522814
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	3/512	44/9376	1.24857954545455	TAF7/TAF10/GTF2H5	0.397200793769479
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	3/512	44/9376	1.24857954545455	APTX/POLG2/PARP4	0.397200793769479
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	3/512	44/9376	1.24857954545455	HLA-B/HSPD1/ICA1	0.397200793769479
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5/512	79/9376	1.15901898734177	UGT2B7/MGST1/GSTK1/MGST3/GSTM4	0.34111189073526
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	6/512	97/9376	1.13273195876289	PLCB1/FOS/GNG5/PLCB4/RPS6KA5/GNG11	0.315803201352716
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	7/512	115/9376	1.11467391304348	PLCB1/FOS/ATF4/GNG5/PLCB4/AKT3/GNG11	0.297365345661469
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	7/512	115/9376	1.11467391304348	PLCB1/DUSP1/MAOA/GNG5/SLC18A2/PLCB4/GNG11	0.297365345661469
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	10/512	169/9376	1.0835798816568	UBB/C9orf72/UBA52/RPS27A/DEPTOR/DDIT4/VAMP8/CTSL/DAPK1/AKT3	0.263506770027331
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	3/512	45/9376	1.22083333333333	DEFB1/ABCD2/ABCA10	0.356872049546588
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	4/512	63/9376	1.16269841269841	PTGES3/PTGR1/GPX4/PLAAT3	0.311397078818752
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	4/512	63/9376	1.16269841269841	ERCC5/RPA2/GTF2H5/POLR2J	0.311397078818752
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/512	28/9376	1.30803571428571	MOCOS/PCBD1	0.392307382846574
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	2/512	28/9376	1.30803571428571	ATP6V1C2/ATP6V1F	0.392307382846574
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	6/512	99/9376	1.10984848484848	DEFB1/KRT19/KRT18/KRT23/KRT10/C3AR1	0.264066698087638
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/512	46/9376	1.19429347826087	UGT2B7/CP/FTL	0.31746953954282
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	5/512	82/9376	1.11661585365854	UGT2B7/MGST1/MGST3/GSTM4/UPP1	0.25489947025301
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	10/512	173/9376	1.05852601156069	DNAJB1/ACTG1/TRADD/ACTB/IFNGR1/CCND3/IRAK4/SOCS3/AKT3/TNFSF10	0.186729534393239
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/512	29/9376	1.26293103448276	WWC1/YAP1	0.340808543070674
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	4/512	65/9376	1.12692307692308	PLCB1/NR4A1/ATF4/PLCB4	0.246777097492329
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	4/512	65/9376	1.12692307692308	SPP1/PLCB1/PLCB4/AKT3	0.246777097492329
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4/512	66/9376	1.10984848484848	UGT2B7/LRTOMT/SULT1E1/HSD17B2	0.215227094709343
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	4/512	66/9376	1.10984848484848	JUN/IFNGR1/IL23A/IL18R1	0.215227094709343
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/512	12/9376	1.52604166666667	SLAMF1	0.438213558410634
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	3/512	48/9376	1.14453125	PLCB1/PLCB4/AKT3	0.241264738782307
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	6/512	103/9376	1.06674757281553	COL1A2/SLC15A1/COL27A1/SLC1A1/SLC3A2/SLC38A2	0.163700386674308
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	7/512	122/9376	1.05071721311475	ACTG1/PLCB1/ACTB/PLCB4/AKT3/THRB/THRA	0.135511544130037
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	3/512	49/9376	1.12117346938776	GALNT4/ST6GAL1/C1GALT1C1	0.204380915049245
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	5/512	86/9376	1.06468023255814	JUN/ERBB3/AKT3/ERBB4/HBEGF	0.144816713192246
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/512	31/9376	1.18145161290323	SRP9/SRPRA	0.243196752873337
Organismal Systems	Endocrine system	hsa04924	Renin secretion	4/512	69/9376	1.06159420289855	PLCB1/PTGER2/PLCB4/KCNMA1	0.123414239886001
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/512	32/9376	1.14453125	LDHA/ECHDC1	0.196823104660676
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	5/512	88/9376	1.04048295454545	C3AR1/SERPINA5/PLAT/F8/CD59	0.0916976442418585
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	6/512	107/9376	1.0268691588785	PLCB1/LDHA/ATF4/PLCB4/AKT3/PYGL	0.0671792674950373
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	9/512	163/9376	1.01111963190184	SLC10A1/JUN/FOS/ATF4/MAP2K6/DDX3X/IRAK4/TGFBR1/AKT3	0.0344183005349445
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	4/512	70/9376	1.04642857142857	TRADD/LEPR/SOCS3/AKT3	0.0937040931207164
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	4/512	70/9376	1.04642857142857	JUN/MET/RAC1/AKT3	0.0937040931207164
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	5/512	89/9376	1.02879213483146	SPP1/COL1A2/FREM2/ITGB8/LAMA5	0.0655898885516964
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	2/512	33/9376	1.10984848484848	VAMP8/STX3	0.15191953119088
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	4/512	71/9376	1.03169014084507	MET/LDHA/FGFR2/AKT3	0.0644170600466491
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	3/512	53/9376	1.03655660377358	PLCB1/CLTA/PLCB4	0.0641404022542203
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/512	15/9376	1.22083333333333	ST8SIA1	0.205709751613275
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/512	15/9376	1.22083333333333	AK4	0.205709751613275
Human Diseases	Cancer: specific types	hsa05218	Melanoma	4/512	73/9376	1.00342465753425	GADD45B/MET/CDH1/AKT3	0.00705948164096019
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	10/512	187/9376	0.97927807486631	HSP90AA1/TXNIP/HSP90AB1/JUN/PLCB1/IRGM/IRAK4/PLCB4/CYBA/GPSM3	-0.068789558611572
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/512	35/9376	1.04642857142857	TPI1/FPGT	0.0661345498900432
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	8/512	150/9376	0.976666666666667	GADD45B/MET/JUP/CDH1/TGFBR1/FGFR2/AKT3/CTNNA1	-0.0692343205801549
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	3/512	55/9376	0.998863636363636	NEU1/GLA/PLPP2	-0.00203129576751348
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	9/512	170/9376	0.969485294117647	ACTG1/MGST1/GADD45B/MET/ACTB/MGST3/GSTM4/TGFBR1/AKT3	-0.0964947996514686
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	4/512	75/9376	0.976666666666667	MGST1/MGST3/GSTM4/AKT3	-0.0487582758213287
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/512	36/9376	1.01736111111111	ENPP3/PYGL	0.0250819370678504
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	2/512	36/9376	1.01736111111111	RPA2/SSBP1	0.0250819370678504
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/512	37/9376	0.989864864864865	RIMKLB/ASRGL1	-0.0148451969250296
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	4/512	77/9376	0.951298701298701	MECOM/GADD45B/TGFBR1/AKT3	-0.103127271207646
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/512	17/9376	1.07720588235294	GGT7	0.07657127395772
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	6/512	117/9376	0.939102564102564	ACTG1/MORF4L2/ACTB/ACTR6/TFPT/CECR2	-0.159299950464633
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/512	38/9376	0.963815789473684	ENPP3/NMRK2	-0.0537142739821728
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	8/512	157/9376	0.93312101910828	CD24/SGK1/ARG2/PTPN6/RAC1/CX3CR1/PTGER2/ADAM10	-0.203096907405903
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	8/512	157/9376	0.93312101910828	HLA-B/GADD45B/IGFBP3/MAP2K6/CCND3/TGFBR1/PPID/AKT3	-0.203096907405903
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	3/512	59/9376	0.93114406779661	ABHD5/AKT3/PLAAT3	-0.127507304659628
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	5/512	99/9376	0.924873737373737	PLCB1/HRH1/MAP2K6/PTGER2/PLCB4	-0.180597339496718
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/512	18/9376	1.01736111111111	NEU1	0.0177185424620778
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/512	18/9376	1.01736111111111	PRDX1	0.0177185424620778
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/512	39/9376	0.939102564102564	HLA-B/CD40LG	-0.0915869035036738
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	9/512	178/9376	0.925912921348315	CACYBP/JUN/PLCB1/LGR4/RAC1/SOX17/CCND3/PLCB4/RAC2	-0.239834421413745
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	6/512	120/9376	0.915625	JUN/ATF4/RAC1/IRAK4/AKT3/RPS6KA5	-0.223562254656667
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	9/512	180/9376	0.915625	HLA-B/SRSF3/TRADD/POU2F2/IFNGR1/CGAS/IRAK4/SOCS3/AKT3	-0.274698508943589
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	5/512	102/9376	0.897671568627451	PLCB1/RAC1/PLCB4/KCNMA1/SLC26A3	-0.249728783629266
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/512	41/9376	0.893292682926829	MAOA/GRHPR	-0.16456395369241
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	2/512	41/9376	0.893292682926829	RPA2/SSBP1	-0.16456395369241
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	10/512	201/9376	0.911069651741294	GADD45B/MET/JUP/PAX8/RUNX2/DDIT3/IGFBP3/BCL6/SPINT1/PLAT	-0.306302633173815
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/512	20/9376	0.915625	MSMO1	-0.0907798419099325
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/512	42/9376	0.872023809523809	MAOA/IDO2	-0.199767884297912
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	5/512	104/9376	0.880408653846154	DGKH/CDS1/PLPP2/PLAAT3/LPIN3	-0.294737542187175
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	7/512	144/9376	0.890190972222222	SCD5/TRADD/MAP2K6/C3AR1/IRAK4/AKT3/LPIN3	-0.319136986302184
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	9/512	184/9376	0.895720108695652	MET/MYL12A/CFL1/SLIT2/EFNA1/RAC1/ARHGEF12/EFNB2/RAC2	-0.343328786480188
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/512	21/9376	0.872023809523809	ENPP3	-0.141098590249692
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	4/512	86/9376	0.851744186046512	PLCB1/ATF4/PLCB4/KCNMA1	-0.331939432485598
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	2/512	44/9376	0.832386363636364	AQP3/DYNLL1	-0.267826820941706
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	6/512	128/9376	0.8583984375	ENPP3/PAPSS1/GDA/APRT/AK4/GUK1	-0.387663457537276
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/512	22/9376	0.832386363636364	MAOA	-0.189159322902208
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	5/512	108/9376	0.847800925925926	EEF1A1/RANBP17/NUP210L/PYM1/SAP18	-0.382328453860592
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	3/512	67/9376	0.819962686567164	PLCB1/ATF4/PLCB4	-0.355430059979086
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	4/512	89/9376	0.823033707865168	GABRP/GNG5/SLC38A2/GNG11	-0.403137851586038
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	5/512	110/9376	0.832386363636364	HSP90AA1/HSP90AB1/ANAPC16/ANAPC13/AKT3	-0.42497686436022
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/512	23/9376	0.796195652173913	ARG2	-0.23518392851412
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/512	23/9376	0.796195652173913	PMVK	-0.23518392851412
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	3/512	68/9376	0.807904411764706	PIM1/JUP/AKT3	-0.382075688858788
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	2/512	47/9376	0.779255319148936	LDHA/GRHPR	-0.364608991863081
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	2/512	47/9376	0.779255319148936	SOCS1/SOCS3	-0.364608991863081
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	7/512	154/9376	0.832386363636364	ACTG1/JUN/PLCB1/FOS/ACTB/PLCB4/RGS2	-0.504037553172632
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	9/512	195/9376	0.845192307692308	ACTG1/PLCB1/NCF1/ACTB/RAC1/PLCB4/CYBA/RAC2/AKT3	-0.525013648547341
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	6/512	134/9376	0.819962686567164	PLCB1/ADM/ARHGEF12/PLCB4/MYH11/KCNMA1	-0.504472719480617
Organismal Systems	Digestive system	hsa04970	Salivary secretion	4/512	93/9376	0.787634408602151	PLCB1/PRH1/PLCB4/KCNMA1	-0.494637678782542
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	4/512	93/9376	0.787634408602151	GADD45B/CKS2/LAMA5/AKT3	-0.494637678782542
NA	NA	hsa04081	Hormone signaling	10/512	219/9376	0.836187214611872	PLCB1/GAST/SLC40A1/SMAD9/LEPR/GNG5/PLCB4/THRB/GNG11/THRA	-0.589520606372678
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/512	26/9376	0.704326923076923	PLAAT3	-0.36282599452347
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	3/512	73/9376	0.752568493150685	PPIA/CD4/MDFIC	-0.510047548559366
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	3/512	73/9376	0.752568493150685	GADD45B/MET/AKT3	-0.510047548559366
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	6/512	138/9376	0.796195652173913	RPS6/SOCS1/FLOT1/SOCS3/AKT3/PYGL	-0.579655223691358
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/512	51/9376	0.718137254901961	PLPP2/PLAAT3	-0.485069636233083
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	8/512	181/9376	0.80939226519337	HSPD1/CORO1A/TRADD/IFNGR1/IL23A/IRAK4/ARHGEF12/AKT3	-0.622314164168252
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/512	27/9376	0.678240740740741	SCD5	-0.402379735318411
Genetic Information Processing	Transcription	hsa03040	Spliceosome	11/512	243/9376	0.828960905349794	HSPA1B/HSPA1A/SRSF3/HSPA8/HSPA6/HSPA1L/HNRNPA1/RBM22/PRPF6/SNRPD1/SYF2	-0.649228448688831
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	4/512	98/9376	0.747448979591837	DGKH/PLCB1/CDS1/PLCB4	-0.604005267818888
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	4/512	98/9376	0.747448979591837	PLCB1/NR4A1/ATF4/PLCB4	-0.604005267818888
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/512	28/9376	0.654017857142857	ACAA2	-0.440635103921877
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/512	28/9376	0.654017857142857	ST8SIA1	-0.440635103921877
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	4/512	99/9376	0.73989898989899	JUN/FOS/AKT3/HBEGF	-0.625261377081073
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	4/512	99/9376	0.73989898989899	ACTG1/SGCD/ACTB/ITGB8	-0.625261377081073
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	2/512	54/9376	0.678240740740741	MTAP/LDHA	-0.56987437518736
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	2/512	54/9376	0.678240740740741	RPA2/CENPX	-0.56987437518736
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/512	54/9376	0.678240740740741	HLA-B/CD40LG	-0.56987437518736
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	6/512	144/9376	0.763020833333333	PLCB1/FGF14/XBP1/PLCB4/AKT3/ADRM1	-0.688730413126453
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	3/512	78/9376	0.704326923076923	PLCB1/TPI1/PLCB4	-0.630187894248521
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	11/512	250/9376	0.80575	LAMTOR4/ATP6V1C2/DEPTOR/NEU1/CLTA/VAMP8/CTSL/GLA/ATP6V1F/VPS29/AP1M2	-0.748163547810877
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/512	30/9376	0.610416666666667	PIGC	-0.513634105305043
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/512	30/9376	0.610416666666667	PLAAT3	-0.513634105305043
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/512	31/9376	0.590725806451613	UGT2B7	-0.548543787036527
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/512	31/9376	0.590725806451613	GRHPR	-0.548543787036527
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	2/512	57/9376	0.642543859649123	SCD5/ACAA2	-0.650550895024055
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	4/512	105/9376	0.697619047619048	JUN/IL23A/ARHGEF12/AKT3	-0.748844310593081
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	4/512	105/9376	0.697619047619048	ACTG1/SGCD/ACTB/ITGB8	-0.748844310593081
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/512	32/9376	0.572265625	GLA	-0.582489998928216
Human Diseases	Immune disease	hsa05310	Asthma	1/512	32/9376	0.572265625	CD40LG	-0.582489998928216
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/512	60/9376	0.610416666666667	PLCB1/PLCB4	-0.72755695961868
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/512	34/9376	0.538602941176471	POLR2J	-0.647739070631291
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/512	34/9376	0.538602941176471	DBP	-0.647739070631291
Organismal Systems	Sensory system	hsa04742	Taste transduction	3/512	86/9376	0.638808139534884	PLCB1/PLCB4/SCNN1A	-0.808695578163443
NA	NA	hsa04082	Neuroactive ligand signaling	8/512	199/9376	0.736180904522613	GABRP/PLCB1/HRH1/SLC1A1/GNG5/SLC18A2/PLCB4/GNG11	-0.904041036077992
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	2/512	62/9376	0.590725806451613	PSENEN/MAML3	-0.77704797744583
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	6/512	156/9376	0.704326923076923	CLDN4/CLDN3/YWHAH/TRADD/SOCS3/AKT3	-0.894982131157383
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/512	36/9376	0.508680555555556	UGT2B7	-0.709818819020165
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	6/512	158/9376	0.695411392405063	GADD45B/YWHAH/ANAPC16/CDKN1C/CCND3/ANAPC13	-0.927960717752244
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/512	37/9376	0.494932432432432	FPGT	-0.739785646763979
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	3/512	90/9376	0.610416666666667	ATF4/AKT3/SOD2	-0.892509873426647
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	8/512	205/9376	0.714634146341463	HLA-B/JUN/YWHAH/TRADD/ATF4/DDX3X/RAC1/CCND3	-0.992833297011684
Human Diseases	Substance dependence	hsa05032	Morphine addiction	3/512	91/9376	0.603708791208791	GABRP/GNG5/GNG11	-0.912956164223982
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	4/512	116/9376	0.631465517241379	GAPDH/TPI1/ENO1/ENO2	-0.959858855793142
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/512	68/9376	0.538602941176471	UGT2B7/CYP26A1	-0.917712898598619
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	6/512	166/9376	0.661897590361446	PLCB1/ATF4/PLCB4/AKT3/RGS2/KCNMA1	-1.05627801319435
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/512	41/9376	0.446646341463415	GABRP	-0.853381645576354
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	2/512	72/9376	0.508680555555556	TRADD/DDX3X	-1.00577559762262
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/512	43/9376	0.425872093023256	ACAA2	-0.906855303633347
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/512	43/9376	0.425872093023256	PLPP2	-0.906855303633347
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	5/512	149/9376	0.614513422818792	DGKH/PLCB1/PLPP2/PLCB4/AKT3	-1.13992920180655
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/512	45/9376	0.406944444444444	HLA-B	-0.958392233688008
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	13/512	333/9376	0.714902402402402	HLA-B/SPP1/COL1A2/ATP6V1C2/TRADD/ITGB8/MAGI1/CCND3/LAMA5/AKT3/MAML3/PATJ/ATP6V1F	-1.27310772692006
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	1/512	46/9376	0.398097826086956	ADRM1	-0.983489552569715
Human Diseases	Cancer: specific types	hsa05214	Glioma	2/512	76/9376	0.481907894736842	GADD45B/AKT3	-1.0898783896382
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	5/512	154/9376	0.594561688311688	PLCB1/ATF4/PLCB4/AKT3/RPS6KA5	-1.21920948091879
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/512	48/9376	0.381510416666667	ACAA2	-1.03243919749186
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/512	50/9376	0.36625	CD40LG	-1.07984398611336
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	3/512	109/9376	0.50401376146789	SOCS3/AKT3/PYGL	-1.25175414830862
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/512	52/9376	0.352163461538462	HSD17B2	-1.1258271644164
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	1/512	52/9376	0.352163461538462	LIPC	-1.1258271644164
Organismal Systems	Digestive system	hsa04976	Bile secretion	2/512	90/9376	0.406944444444444	UGT2B7/SLC10A1	-1.35865139377247
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	4/512	148/9376	0.494932432432432	GADD45B/JUN/FOS/AKT3	-1.48844328582739
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	3/512	122/9376	0.45030737704918	SCD5/LEPR/AKT3	-1.46872612981343
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	7/512	226/9376	0.567201327433628	JUN/FOS/RAC1/PTGER2/RAC2/AKT3/AFDN	-1.58283388000657
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	8/512	254/9376	0.576771653543307	MET/PLCB1/HRH1/VEGFB/PLCB4/FGFR2/ERBB3/ERBB4	-1.64343418694284
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/512	63/9376	0.290674603174603	MECOM	-1.35761531314273
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	1/512	63/9376	0.290674603174603	GADD45B	-1.35761531314273
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	4/512	155/9376	0.47258064516129	PLCB1/NR4A1/ATF4/PLCB4	-1.59125084114168
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	2/512	101/9376	0.362623762376238	PLCB1/PLCB4	-1.54776613824707
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	2/512	103/9376	0.355582524271845	PYM1/SAP18	-1.58045282407377
Human Diseases	Substance dependence	hsa05034	Alcoholism	5/512	191/9376	0.479384816753927	ATF4/MAOA/GNG5/SLC18A2/GNG11	-1.74702724562727
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	3/512	138/9376	0.398097826086956	YWHAH/ANAPC16/ANAPC13	-1.71191509396848
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	12/512	370/9376	0.593918918918919	RXFP1/GABRP/GAL/HRH1/LEPR/ADM/C3AR1/PTGER2/S1PR4/THRB/THRA/PYY	-1.91537313767173
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	1/512	76/9376	0.240953947368421	SCD5	-1.59675833910485
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	1/512	83/9376	0.220632530120482	UBE2D2	-1.7139932109497
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	1/512	83/9376	0.220632530120482	CGAS	-1.7139932109497
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	3/512	154/9376	0.356737012987013	UGT2B7/IDO2/AK4	-1.93438140866494
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	2/512	143/9376	0.256118881118881	CD40LG/SNRPD1	-2.15429851250064
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	8/512	323/9376	0.453560371517028	MET/SOCS1/PIM1/EFNA1/DDIT4/VIM/ERBB3/RPS6KA5	-2.40188900088929
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	3/512	183/9376	0.300204918032787	IMP3/SBDS/NOP10	-2.29759536165642
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/512	449/9376	0.0407850779510022	RGS2	-5.00601416746342