category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	48/1002	138/9376	3.25470797535364	NDUFS5/NDUFA3/ATP5MF/NDUFB7/COX5B/COX8A/NDUFB2/COX7B/COX7C/UQCRQ/ATP6V1C2/COX6B1/NDUFA2/NDUFB9/NDUFA7/UQCRH/UQCR11/MT-ATP8/COX6C/ATP5ME/NDUFB8/NDUFV3/UQCR10/NDUFB5/NDUFC1/CYCS/ATP6V1H/ATP5MC1/ATP6V0D1/ATP6V1D/NDUFB11/COX17/NDUFS4/NDUFB4/NDUFS3/NDUFB10/ATP5PD/NDUFA11/ATP5MG/ATP5PF/NDUFA6/NDUFS6/NDUFB3/UQCRFS1/ATP5PO/NDUFB1/COX7A2/COX15	9.22983390891426
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	78/1002	308/9376	2.36970215413329	NDUFS5/NDUFA3/NDUFB7/TUBB4B/COX5B/COX8A/NDUFB2/COX7B/COX7C/UQCRQ/COX6B1/NDUFA2/NDUFB9/TUBA1C/NDUFA7/UQCRH/UQCR11/SLC25A6/SLC25A4/MT-ATP8/PPARG/DCTN3/COX6C/POLR2L/DNALI1/NDUFB8/NDUFV3/UQCR10/NDUFB5/POLR2F/POLR2I/WIPI2/REST/NDUFC1/CYCS/ATP5MC1/CLTB/NDUFB11/PSMC3/NDUFS4/NRBF2/NDUFB4/NDUFS3/POLR2H/NDUFB10/ATP5PD/NDUFA11/POLR2K/KLC1/POLR2B/TUBA1B/ATP5PF/NDUFA6/NDUFS6/NDUFB3/UQCRFS1/EP300/DNAH11/ATG14/DNAL4/POLR2D/ATP5PO/NDUFB1/COX7A2/CASP8/TUBA4A/CASP9/ULK2/DNAH14/DNAH5/PIK3R4/APAF1/TUBB2A/BBC3/DNAH12/DNAH7/MAP2K7/MTOR	8.45471090090024
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	63/1002	235/9376	2.50854885972735	GNAS/NDUFS5/NDUFA3/ATP5MF/NDUFB7/COX5B/COX8A/NDUFB2/COX7B/COX7C/UQCRQ/PRKACB/COX6B1/NDUFA2/RPS6/NDUFB9/SLC25A29/NDUFA7/UQCRH/UQCR11/RPS6KA2/ACSL1/MT-ATP8/CPT1A/PPARG/COX6C/ATP5ME/NDUFB8/NDUFV3/UQCR10/NDUFB5/NDUFAF8/NDUFC1/ATP5MC1/MGLL/RPS6KB2/NDUFB11/SMARCC1/PRKAA2/COX17/NDUFS4/NDUFB4/NDUFS3/NDUFB10/ATP5PD/COX14/GRB2/NDUFA11/ATP5MG/SMARCA2/ATP5PF/NDUFA6/NDUFS6/NDUFB3/UQCRFS1/KDM3A/CPT2/KDM3B/ATP5PO/NDUFB1/COX7A2/COX15/MTOR	8.10120231732055
Genetic Information Processing	Translation	hsa03010	Ribosome	59/1002	222/9376	2.48684612756469	RPL27A/RPS10/UBA52/RPL31/RPS8/RPL41/RPL37/RPL13A/RPL26/RPS12/RPS6/RSL24D1/RPL19/RPL38/RPS25/RPS27/RPL30/RPS3/RPS21/MRPS21/MRPS18C/RPL34/MRPL34/RPL6/MRPL36/MRPL2/RPS15/RPL35A/RPL5/RPL17/MRPL40/MRPS18B/MRPS14/RPL21/RPS13/RPS20/RPL32/MRPL11/MRPS35/MRPS34/RPS16/RPL36A/RPL35/MRPL13/RPL27/RPL10/RPSA/MRPL48/MRPL52/RACK1/MRPL15/RPL37A/MRPL14/RPLP2/RPL23/RPS15A/RPS27L/MRPS27/RPL28	7.75514781434623
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	53/1002	205/9376	2.41920062314396	NDUFS5/GAPDH/NDUFA3/NDUFB7/PDK4/COX5B/COX8A/NDUFB2/COX7B/COX7C/MPC1/UQCRQ/COX6B1/NDUFA2/NDUFB9/NDUFA7/UQCRH/UQCR11/SLC25A6/SLC25A4/MT-ATP8/COX6C/NDUFB8/NDUFV3/UQCR10/NDUFB5/NDUFC1/ATP5MC1/NDUFB11/NDUFS4/NDUFB4/NDUFS3/NDUFB10/ATP5PD/NDUFA11/PARP1/ATP5PF/NDUFA6/NDUFS6/PIK3CB/NDUFB3/UQCRFS1/G6PD/CD36/CPT2/ATP5PO/CTSD/NDUFB1/COX7A2/PIK3R3/ACE/IRS1/MTOR	7.10665769995354
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	78/1002	368/9376	1.98333767248112	NDUFS5/MAP2K6/NDUFA3/NDUFB7/TUBB4B/COX5B/COX8A/NDUFB2/COX7B/COX7C/UQCRQ/COX6B1/NDUFA2/NDUFB9/TUBA1C/NDUFA7/UQCRH/UQCR11/MT-ATP8/DCTN3/COX6C/DNALI1/NDUFB8/NDUFV3/UQCR10/NDUFB5/WIPI2/NDUFC1/NUP98/CYCS/ATP5MC1/NDUFB11/MAP1LC3B/MAP1LC3A/PSMC3/NDUFS4/NRBF2/OPTN/NDUFB4/NDUFS3/TARDBP/NDUFB10/ATP5PD/NDUFA11/KLC1/TUBA1B/ATP5PF/NDUFA6/NDUFS6/NDUFB3/UQCRFS1/ANXA11/DNAH11/ATG14/WDR41/DNAL4/ATP5PO/NDUFB1/TOMM40/CASP1/COX7A2/FIG4/TPR/NUP85/TUBA4A/CASP9/NUP43/ULK2/DNAH14/DNAH5/PIK3R4/APAF1/TUBB2A/DNAH12/DNAH7/SMCR8/NUP62/MTOR	6.65679861944216
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	54/1002	227/9376	2.22596217257116	NDUFS5/NDUFA3/NDUFB7/COX5B/COX8A/AHR/NDUFB2/COX7B/COX7C/UQCRQ/COX6B1/NDUFA2/AKR1A1/NDUFB9/NDUFA7/UQCRH/UQCR11/SLC26A2/SLC25A6/SLC25A4/MT-ATP8/COX6C/NDUFB8/NDUFV3/UQCR10/NDUFB5/NDUFC1/ATP5MC1/NDUFB11/MGST2/NDUFS4/NDUFB4/NDUFS3/NDUFB10/ATP5PD/GRB2/NDUFA11/ATP5PF/NDUFA6/NDUFS6/PIK3CB/NDUFB3/UQCRFS1/MAPK3/ATP5PO/NDUFB1/GSTM4/COX7A2/CHUK/PIK3R3/MET/GSTA4/MAP2K7/PRKD2	6.46779439414866
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	41/1002	157/9376	2.44362230952109	NDUFS5/NDUFA3/NDUFB7/COX5B/COX8A/NDUFB2/COX7B/COX7C/UQCRQ/COX6B1/NDUFA2/NDUFB9/NDUFA7/UQCRH/UQCR11/PPARG/COX6C/NDUFB8/NDUFV3/UQCR10/NDUFB5/NDUFC1/CYCS/NDUFB11/PRKAA2/NDUFS4/NDUFB4/NDUFS3/NDUFB10/NDUFA11/NDUFA6/NDUFS6/PIK3CB/NDUFB3/UQCRFS1/NDUFB1/COX7A2/PIK3R3/CASP8/IRS1/NR1H3	6.30978446309659
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	23/1002	63/9376	3.41615182333745	POLR2M/RFC1/POLR2L/POLR2F/POLR2I/CETN2/ERCC1/RPA3/POLR2H/POLR2K/XPC/XPA/POLR2B/RFC5/POLD3/ERCC5/RPA2/POLR2D/DDB2/GTF2H3/RFC3/ERCC8/RFC4	6.65583756397766
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	18/1002	44/9376	3.8279804028307	RFC1/PARP4/MPG/PARP1/SMUG1/RFC5/POLD3/TDP1/MBD4/XRCC1/TDG/PARP2/OGG1/RFC3/UNG/NEIL2/RFC4/MUTYH	6.50381814688667
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	56/1002	268/9376	1.95525367176096	GNAS/NDUFS5/NDUFA3/UBA52/NDUFB7/TUBB4B/COX5B/COX8A/NDUFB2/COX7B/COX7C/DUSP1/UQCRQ/PRKACB/COX6B1/NDUFA2/NDUFB9/TUBA1C/NDUFA7/UQCRH/UQCR11/SLC25A6/SLC25A4/MT-ATP8/COX6C/NDUFB8/NDUFV3/UQCR10/NDUFB5/NDUFC1/CYCS/MFN1/ATP5MC1/NDUFB11/PSMC3/NDUFS4/NDUFB4/NDUFS3/NDUFB10/ATP5PD/NDUFA11/KLC1/TUBA1B/ATP5PF/NDUFA6/NDUFS6/NDUFB3/UQCRFS1/ATP5PO/NDUFB1/COX7A2/TUBA4A/CASP9/APAF1/TUBB2A/MAPT	5.48817084574194
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	25/1002	83/9376	2.81845946660895	PRDX5/PHYH/ECH1/ACSL1/DECR2/MPV17/PEX2/PMVK/PECR/SCP2/PEX7/ABCD3/MLYCD/PEX19/ACOT8/NUDT12/AMACR/PEX11G/SLC25A17/EHHADH/CROT/ACOX3/PEX11A/HACL1/MPV17L2	5.75595941906952
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	56/1002	275/9376	1.90548357829795	NDUFS5/NDUFA3/NDUFB7/TUBB4B/COX5B/COX8A/NDUFB2/COX7B/COX7C/UQCRQ/PRKACB/COX6B1/NDUFA2/NDUFB9/TUBA1C/NDUFA7/UQCRH/UQCR11/SLC25A6/SLC25A4/MT-ATP8/COX6C/NDUFB8/NDUFV3/UQCR10/NDUFB5/CSNK2A1/NDUFC1/CYCS/ATP5MC1/NDUFB11/PSMC3/NDUFS4/NDUFB4/NDUFS3/HSPA1B/NDUFB10/ATP5PD/NDUFA11/KLC1/TUBA1B/ATP5PF/NDUFA6/NDUFS6/PIK3CB/NDUFB3/UQCRFS1/MAPK3/ATP5PO/NDUFB1/COX7A2/PIK3R3/TUBA4A/CASP9/APAF1/TUBB2A	5.27175706638579
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	50/1002	238/9376	1.96581626662641	RPL27A/RPS10/UBA52/RPL31/RPS8/RPL41/RPL37/PLCG2/RPL13A/RPL26/RPS12/RPS6/RSL24D1/RPL19/RPL38/RPS25/RPS27/RPL30/RPS3/RPS21/RPL34/RPL6/RPS15/RPL35A/RPL5/RPL17/RPL21/RPS13/RPS20/RPL32/IRAK4/RPS16/RPL36A/RPL35/RPL27/RPL10/PIK3CB/RPSA/OAS1/RPL37A/RPLP2/MAPK3/RPL23/CASP1/RPS15A/RPS27L/CHUK/PIK3R3/RPL28/ACE	5.2204800208642
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	83/1002	480/9376	1.61803060545576	NDUFS5/MAP2K6/NDUFA3/UBA52/NDUFB7/TUBB4B/COX5B/COX8A/NDUFB2/COX7B/COX7C/UQCRQ/COX6B1/NDUFA2/NDUFB9/TUBA1C/NDUFA7/UQCRH/UQCR11/SLC25A6/SLC25A4/CSNK1A1/MT-ATP8/DCTN3/COX6C/DNALI1/NDUFB8/NDUFV3/UQCR10/NDUFB5/WIPI2/CSNK2A1/NDUFC1/CYCS/MFN1/ATP5MC1/NDUFB11/MAP1LC3B/MAP1LC3A/PSMC3/NDUFS4/NRBF2/OPTN/NDUFB4/NDUFS3/TARDBP/NDUFB10/ATP5PD/NDUFA11/KLC1/TUBA1B/ATP5PF/NDUFA6/NDUFS6/NDUFB3/UQCRFS1/DNAH11/MAPK3/ATG14/WDR41/DNAL4/ATP5PO/NDUFB1/TOMM40/COX7A2/FIG4/CASP8/FADD/TUBA4A/CASP9/ULK2/DNAH14/DNAH5/PIK3R4/APAF1/TUBB2A/DNAH12/FZD6/MAPT/DNAH7/MAP2K7/SMCR8/MTOR	4.80824107947897
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	70/1002	388/9376	1.68817005164928	NDUFS5/GAPDH/NDUFA3/NDUFB7/TUBB4B/COX5B/COX8A/NDUFB2/COX7B/COX7C/UQCRQ/COX6B1/NDUFA2/NDUFB9/TUBA1C/NDUFA7/UQCRH/UQCR11/SLC25A6/SLC25A4/CSNK1A1/MT-ATP8/COX6C/NDUFB8/NDUFV3/UQCR10/NDUFB5/WIPI2/CSNK2A1/NDUFC1/CYCS/ATP5MC1/NAE1/NDUFB11/PSMC3/NDUFS4/NRBF2/NDUFB4/NDUFS3/NDUFB10/ATP5PD/NDUFA11/KLC1/TUBA1B/ATP5PF/NDUFA6/NDUFS6/PIK3CB/NDUFB3/UQCRFS1/MAPK3/ATG14/ATP5PO/NDUFB1/COX7A2/CHUK/PIK3R3/CASP8/FADD/TUBA4A/CASP9/ULK2/PIK3R4/APAF1/TUBB2A/FZD6/MAPT/IRS1/MAP2K7/MTOR	4.78887080053689
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	37/1002	170/9376	2.03658565222496	MYL12B/MYL6/MYL6B/PRKACB/AFDN/PPP2R1B/MYL12A/TUBA1C/RAB13/CLDN4/TJP1/RDX/MYH14/ROCK1/PRKAA2/ARPC1B/HSPA4/WHAMM/TUBA1B/NEDD4L/CLDN15/MYH9/RUNX1/ARHGAP17/ARHGEF18/TUBA4A/CGN/AMOTL2/CLDN1/RAPGEF6/AMOTL1/ERBB2/F11R/MARVELD2/MAP2K7/NF2/DLG3	4.7178832488415
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	13/1002	34/9376	3.57778560526007	POLR3K/CRCP/POLR2M/POLR2L/POLR2F/POLR2I/POLR3H/POLR2H/POLR2K/POLR2B/POLR2D/POLR3F/POLR1B	5.20858003516339
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	46/1002	248/9376	1.73562552314725	MAP2K6/GAPDH/TUBB4B/MYL12B/DYNC1I1/GCC2/CASP4/MYL12A/TUBA1C/AHNAK/RPS3/RIPK2/DCTN3/RHOB/ANXA2/KPNA4/CYCS/DYNC1LI2/STX10/ACBD3/ARPC1B/IRAK4/PIK3C2A/PAK1/KLC1/TUBA1B/PIK3CB/DYNLRB1/MAPK3/CASP1/IL18/CHUK/RILP/MYO6/CASP8/FYCO1/VPS41/FADD/TNFSF10/TUBA4A/VPS16/TUBB2A/DYNLRB2/MAP2K7/RIPK3/TLR5	4.06113881446706
Cellular Processes	Cell motility	hsa04814	Motor proteins	38/1002	194/9376	1.83287034179065	TUBB4B/MYL12B/DYNC1I1/MYL6/MYL6B/MYL12A/TUBA1C/KIF9/ACTG2/DCTN3/DNALI1/DYNC1LI2/MYH14/KIF2A/KIF27/TPM4/KIF1B/KLC1/TUBA1B/MYH9/DNAH11/DYNLRB1/TUBG1/DNAL4/MYO1E/MYO5B/KIF20B/MYO6/TUBA4A/KIF16B/DNAH14/DNAH5/TUBB2A/KIF1C/DNAH12/DNAH7/DYNLRB2/MYO19	4.054736520619
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	19/1002	75/9376	2.3705123087159	MDM2/CYCS/ERCC1/MGST2/GSTP1/XPA/PIK3CB/MAPK3/TOP2B/GSTM4/PIK3R3/CASP8/MSH6/FADD/CASP9/APAF1/BBC3/ERBB2/GSTA4	4.12194099414712
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	32/1002	158/9376	1.8951464160287	SGK1/TBC1D7/LPIN2/CLIP1/ATP6V1C2/DEPTOR/RNF152/RPS6/RPS6KA2/EIF4B/MIOS/ATP6V1H/MAPKAP1/ATP6V1D/RPS6KB2/PRKAA2/GRB2/CASTOR2/LAMTOR4/PIK3CB/RRAGD/MAPK3/CHUK/PIK3R3/FNIP1/LPIN3/ULK2/EIF4EBP1/WDR59/FZD6/IRS1/MTOR	3.92515932224909
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	9/1002	23/9376	3.66154647227285	RFC1/RPA3/RFC5/POLD3/RPA2/MSH6/RFC3/PMS2/RFC4	4.42054204024612
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	15/1002	54/9376	2.59924595253937	CENPS/ERCC1/RPA3/CENPX/RAD51C/REV1/USP1/FANCF/WDR48/RPA2/FAN1/PMS2/PALB2/RMI2/FAAP24	4.07671744281471
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	11/1002	36/9376	2.8591705477933	RFC1/RNASEH2C/RPA3/RFC5/POLD3/RPA2/RFC3/MCM4/PRIM1/RFC4/POLA2	3.86589508591331
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	18/1002	78/9376	2.15937356057117	MPHOSPH6/LSM3/EXOSC1/CNOT6L/PFKP/LSM4/TOB1/PABPC1/CNOT7/DCP2/EXOSC9/MTREX/TOB2/EXOSC8/EXOSC3/PABPC4L/CNOT6/EXOSC5	3.55655020119572
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	22/1002	105/9376	1.96057408991541	UBA52/BNIP3L/CITED2/SAMM50/FKBP8/GABARAPL1/CSNK2A1/MFN1/OPA1/MAP1LC3B/MAP1LC3A/USP8/OPTN/FUNDC1/TFEB/TOMM40/RABGEF1/TBC1D15/MTX3/SIAH1/MON1B/NLRX1	3.42385408256743
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	10/1002	33/9376	2.83554103913385	VAMP5/STX18/STX19/STX8/VTI1B/VAMP7/STX7/STX3/VAMP4/VAMP8	3.65368342602517
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	31/1002	169/9376	1.7164251378899	UBA52/PRKACB/DEPTOR/GABARAPL1/WIPI2/RPS6KB2/PRKAA2/MAP1LC3B/MAP1LC3A/NRBF2/OPTN/IGBP1/STX7/ATG10/PIK3CB/RRAGD/MAPK3/ATG14/WDR41/CTSD/CAMKK2/PIK3R3/VPS41/VAMP8/ULK2/VPS16/DAPK3/PIK3R4/IRS1/SMCR8/MTOR	3.25093373625333
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	12/1002	48/9376	2.33932135728543	PCCA/BCKDHB/HADH/HIBADH/ALDH3A2/BCAT2/OXCT1/AUH/DBT/MMUT/MCCC1/EHHADH	3.21783791801597
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	34/1002	200/9376	1.59073852295409	GAPDH/TUBB4B/CASP4/TUBA1C/CLDN4/TJP1/RPS3/NCK1/CYCS/MYH14/ROCK1/ARPC1B/IRAK4/PAK1/TUBA1B/GNA13/CLDN15/MYH9/MAPK3/MYO1E/CASP1/IL18/CHUK/MYO5B/MYO6/CASP8/FADD/TNFSF10/TUBA4A/CASP9/CLDN1/TUBB2A/ABCF2/TLR5	2.92103397840433
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	16/1002	75/9376	1.99622089155023	CCNG2/MDM2/PERP/CYCS/SIVA1/GADD45B/SESN1/CCNE1/DDB2/SIAH1/CASP8/RCHY1/CASP9/APAF1/BBC3/CCNB1	2.99622535747537
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	25/1002	142/9376	1.64740940653903	UBA52/UBE2H/CBLC/UBE2D2/MDM2/CUL3/CUL5/MID1/UBE3A/ANAPC11/UBE2D4/UBE2Q1/STUB1/TRIP12/NEDD4L/ANAPC16/CUL2/DDB2/ANAPC7/SIAH1/RCHY1/PIAS4/ERCC8/UBOX5/ANAPC1	2.68894093691005
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	39/1002	253/9376	1.44242739816809	RPS6KA5/UBA52/MYL12B/PLCG2/CASP4/MYL12A/UBE2D2/MDM2/FOXO1/RIPK2/SEPTIN11/MALT1/WIPI2/CYCS/ROCK1/CAST/UBE2D4/FNBP1L/FNBP1/RPS6KB2/CD44/MAP1LC3B/MAP1LC3A/ARPC1B/SEPTIN8/PIK3CB/RRAGD/MAPK3/ATG14/CASP1/IL18/CHUK/PIK3R3/HK1/PLCE1/PIK3R4/GLMN/MTOR/TLR5	2.4676664554798
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	6/1002	19/9376	2.95493224078159	BCKDHB/GCSH/OGDH/DBT/AMT/LIAS	2.95048367130625
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	23/1002	133/9376	1.61817717947563	SGK1/CCNG2/MDM2/USP7/FOXO1/GABARAPL1/CDKN1B/PRKAA2/HOMER2/GRB2/SGK3/PIK3CB/EP300/GADD45B/MAPK3/CHUK/CDKN2B/PIK3R3/TNFSF10/PLK2/FBXO32/CCNB1/IRS1	2.4836210572625
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	16/1002	83/9376	1.80381405862973	UBE2D2/USP7/USP16/RYBP/UBE2D4/TFDP1/EZH1/EP300/L3MBTL2/FOXK2/BAP1/CBX8/CBX7/BCOR/PCGF6/USP45	2.54430807334857
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	25/1002	149/9376	1.57001433374861	NDUFS5/NDUFA3/NDUFB7/NDUFB2/PRKACB/NDUFA2/NDUFB9/NDUFA7/NDUFB8/NDUFV3/NDUFB5/NDUFC1/MGLL/NDUFB11/NDUFS4/NDUFB4/NDUFS3/NDUFB10/NDUFA11/NDUFA6/NDUFS6/NDUFB3/MAPK3/NDUFB1/GNG7	2.42606074797384
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	12/1002	57/9376	1.96995482718773	HADH/ACSL1/CPT1A/HSD17B8/MECR/TECR/SCP2/CPT2/MCAT/EHHADH/ACOX3/HSD17B12	2.54072289659789
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	6/1002	21/9376	2.67351012261192	ENPP3/ALDH3A2/BCAT2/PPCS/COASY/PANK1	2.65563947582743
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	23/1002	138/9376	1.55954757152362	PRKACB/RPS6/FBP1/FOXO1/MKNK2/RPS6KB2/PRKAR2A/PRKAA2/GRB2/PPP1R3B/PIK3CB/TRIP10/PYGB/MAPK3/PPP1R3D/PIK3R3/HK1/EIF4EBP1/SOCS4/PPP1R3F/IRS1/PPP1R3E/MTOR	2.29055434484339
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	25/1002	154/9376	1.51903984239314	AKR1A1/RFK/IDO2/MOCS2/ALDH3A2/NME3/BCAT2/PPCS/QPRT/COQ4/NAPRT/COASY/SHMT1/MTHFD2L/UGT2B7/AK7/ALAS1/RDH13/NME6/COQ3/LIAS/PPOX/COQ2/COX15/PANK1	2.24647463064717
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	19/1002	110/9376	1.6162583923063	GAPDH/PLCG2/RPS6/CDKN1B/MKNK2/PFKP/RPS6KB2/EGLN2/PIK3CB/EP300/MAPK3/CUL2/PIK3R3/EPAS1/ALDOC/HK1/EIF4EBP1/ERBB2/MTOR	2.24887885977985
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	9/1002	41/9376	2.05403826493355	GCSH/GRHPR/SHMT1/ALAS1/AMT/BPGM/PHGDH/GAMT/CTH	2.33961375146261
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	9/1002	41/9376	2.05403826493355	BABAM1/RPA3/RAD51C/NBN/POLD3/RPA2/BRCC3/RBBP8/PALB2	2.33961375146261
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	11/1002	56/9376	1.83803820929569	EEF1A1/EEF1G/CYCS/HSPA1B/HBS1L/CASP1/IL18/CASP8/CASP9/APAF1/TLR5	2.17571947024506
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	12/1002	63/9376	1.78234008174128	HADH/ALDH3A2/MECOM/KMT5B/NSD1/EZH1/EHMT2/NSD3/PRDM2/SETMAR/EHHADH/NSD2	2.15513299022174
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	9/1002	43/9376	1.95850160144827	HADH/ACSL1/ALDH3A2/CPT1A/ECI1/CPT2/EHHADH/ACOX3/ADH1C	2.17906135353217
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	18/1002	108/9376	1.55954757152362	EEF1A1/KPNA4/NUP98/UPF3A/UPF3B/SUMO3/UPF1/UPF2/PHAX/SNUPN/DDX19B/TPR/NMD3/NUP85/IPO8/THOC5/NUP43/NUP62	2.02306064189667
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	18/1002	109/9376	1.54523979563808	SLC27A4/FOXO1/RPS6KA2/CPT1A/NR1H2/SLC27A5/RPS6KB2/PRKAA2/PPP1R3B/PIK3CB/CD36/PYGB/PPP1R3D/PIK3R3/IRS1/PPP1R3E/NR1H3/MTOR	1.9805428111548
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	9/1002	44/9376	1.91399020141535	TAF11/GTF2A1/TAF9/TAF10/GTF2I/GTF2H3/TAF2/TAF6L/TAF1	2.10200397856068
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	7/1002	31/9376	2.11293541948361	PCCA/GCSH/GRHPR/ACO2/SHMT1/AMT/MMUT	2.14691168097598
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	8/1002	38/9376	1.96995482718773	SGK1/FXYD4/PIK3CB/NEDD4L/MAPK3/PIK3R3/HSD11B2/IRS1	2.07238000270633
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	24/1002	158/9376	1.42135981202153	PPP2R1B/CDC14A/MDM2/WAPL/WEE1/CDKN1B/STAG2/ANAPC11/YWHAB/ESCO1/TFDP1/EP300/GADD45B/ANAPC16/SMC1A/CCNE1/ANAPC7/CDKN2B/CDKN1C/TRIP13/MCM4/CCNB1/TTK/ANAPC1	1.84763560973067
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	7/1002	32/9376	2.04690618762475	PCCA/BCKDHB/MLYCD/DBT/MMUT/EHHADH/ACOX3	2.05196222561524
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	7/1002	32/9376	2.04690618762475	GABARAPL1/WIPI2/IGBP1/ATG10/ULK2/PIK3R4/MTOR	2.05196222561524
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	7/1002	32/9376	2.04690618762475	SEPTIN4/CYCS/CASP8/FADD/CASP9/APAF1/BBC3	2.05196222561524
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	14/1002	83/9376	1.57833730130101	POLR3K/POLR2L/POLR2F/POLR3H/POLR2H/POLR2K/CASP1/IL18/CHUK/CASP8/FADD/POLR3F/RIPK3/DNASE2	1.83060777429947
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	21/1002	137/9376	1.43432842344508	TUBA1C/SEPTIN4/PARP4/CYCS/LMNA/PARP1/TUBA1B/PIK3CB/GADD45B/MAPK3/CTSD/CHUK/PIK3R3/CASP8/PARP2/FADD/TNFSF10/TUBA4A/CASP9/APAF1/BBC3	1.77140991920172
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	35/1002	250/9376	1.31001996007984	CBLC/MDM2/RAB11FIP1/CHMP4C/SMAP2/VPS37B/RAB22A/SPART/MVB12A/CLTB/ARFGEF1/EEA1/CHMP3/USP8/ARPC1B/HSPA1B/RUFY1/EPN2/NEDD4L/ARAP2/ARFGAP2/STAM/PDCD6IP/RBSN/CHMP2A/IQSEC2/RABEP1/ARFGEF2/ZFYVE9/WASHC2C/GRK6/FGFR2/VPS45/RAB35/GIT2	1.71859066634524
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	13/1002	76/9376	1.60058829709003	SLC27A4/ACSL1/CPT1A/PPARG/DBI/SLC27A5/SCP2/CD36/CPT2/EHHADH/ACOX3/NR1H3/RXRB	1.81842422303342
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	11/1002	62/9376	1.66016354387998	CRYAB/PRKACB/FOXO1/RPS6KB2/PRKAA2/HSPA1B/PIK3CB/PIK3R3/IRS1/MTOR/FOXA2	1.80398235906467
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	12/1002	70/9376	1.60410607356715	EGLN2/GRB2/PAK1/PIK3CB/EP300/FH/MAPK3/CUL2/PIK3R3/EPAS1/MET/PAK6	1.75482461911621
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	15/1002	93/9376	1.50923958534544	CDKN1B/CYCS/CKS2/TRAF4/PIK3CB/GADD45B/CCNE1/DDB2/CHUK/CDKN2B/PIK3R3/CASP9/APAF1/RXRB/LAMB4	1.70715311788077
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	14/1002	86/9376	1.52327902334865	PLCG2/CDKN1B/NCK1/RPS6KB2/GRB2/PAK1/PIK3CB/MAPK3/PIK3R3/EIF4EBP1/ERBB2/MAP2K7/PAK6/MTOR	1.68627233436265
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	34/1002	250/9376	1.27259081836327	ATP6V1C2/DEPTOR/BLOC1S1/BORCS7/ATP6V1H/CLTB/VAMP7/ATP6V0D1/KXD1/ATP6V1D/DMXL1/TFEB/LAMTOR4/RRAGD/AP1S3/BLOC1S5/CTSD/SLC11A1/HEXA/AP1G1/FIG4/AP3S2/HYAL3/VPS41/BORCS5/VAMP8/AGA/AP5M1/GLB1/AP3D1/VPS16/AP5S1/DNASE2/MTOR	1.51110282076639
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	5/1002	23/9376	2.03419248459603	FNTA/GGPS1/PMVK/PDSS2/FDPS	1.7176823337446
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	7/1002	37/9376	1.77029724335114	PPARG/NCOA4/GADD45B/MAPK3/DDB2/TPR/RXRB	1.62391030843904
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	16/1002	106/9376	1.4124204421346	MDM2/FOXO1/CDKN1B/GSTP1/GRB2/PIK3CB/EP300/MAPK3/CCNE1/SPINT1/CHUK/PIK3R3/CASP9/FGFR2/ERBB2/MTOR	1.47708765932803
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	4/1002	17/9376	2.20171421862158	SLC27A5/SCP2/ACOT8/AMACR	1.71539427963389
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	11/1002	68/9376	1.51367852530234	RPS6KB2/PER2/GRB2/JUP/PIK3CB/MAPK3/CHUK/RUNX1/PIK3R3/EIF4EBP1/MTOR	1.47051920186709
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	6/1002	31/9376	1.81108750241453	IMMP1L/SRP9/UBL4A/GET3/OXA1L/SGTA	1.5646309774518
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	17/1002	116/9376	1.37132631289146	PCCA/GAPDH/FBP1/GCSH/OGDH/PFKP/ACO2/SHMT1/G6PD/FH/GPT2/AMT/MMUT/PHGDH/ALDOC/HK1/ACOX3	1.39197760205651
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	12/1002	77/9376	1.45827824869741	MDM2/MECOM/CDKN1B/GRB2/PIK3CB/GADD45B/MAPK3/DDB2/CHUK/RUNX1/PIK3R3/BCR	1.39672048956861
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	14/1002	93/9376	1.40862361298908	MYL12B/AFDN/MYL12A/TJP1/CSNK2A1/ROCK1/CTNNA1/IQGAP1/EP300/PTPRM/MAPK3/ARHGAP29/ERBB2/MET	1.36985241334058
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	4/1002	18/9376	2.07939676203149	ACSL1/HSD17B8/MECR/MCAT	1.58554606357162
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	8/1002	47/9376	1.59272943474753	AKR1A1/ALDH3A2/GRHPR/LDHD/HAGH/FH/ACYP1/ADH1C	1.40909702443699
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	3/1002	12/9376	2.33932135728543	COQ4/COQ3/COQ2	1.60582322751763
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	13/1002	87/9376	1.39821506412462	COX5B/COX8A/COX7B/COX7C/UQCRQ/COX6B1/UQCRH/UQCR11/COX6C/UQCR10/TPM4/UQCRFS1/COX7A2	1.29076104665946
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	13/1002	87/9376	1.39821506412462	RALB/CYCS/RPS6KB2/GRB2/PIK3CB/GADD45B/MAPK3/DDB2/PIK3R3/MSH6/CASP9/BBC3/MTOR	1.29076104665946
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	6/1002	33/9376	1.70132462348031	BCKDHB/BCAT2/OGDH/ACO2/GPT2/DBT	1.39600155945437
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	12/1002	80/9376	1.40359281437126	PLCG2/RPS6/RPS6KB2/GRB2/PIK3CB/MAPK3/PIK3R3/EIF4EBP1/FGFR2/ERBB2/MET/MTOR	1.25398800433606
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	6/1002	34/9376	1.65128566396619	PRKAA2/NFIL3/PER2/DBP/NR1D2/CLOCK	1.31596417467781
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	11/1002	73/9376	1.41000191398026	PLCG2/GRB2/PIK3CB/GADD45B/MAPK3/DDB2/PIK3R3/CASP9/ERBB2/MET/RXRB	1.21643476736293
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	5/1002	27/9376	1.73283063502624	ACOT4/TECR/SCP2/ACOX3/HSD17B12	1.31903384441409
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	7/1002	42/9376	1.55954757152362	FTH1/ACSL1/SAT2/GPX4/MAP1LC3B/MAP1LC3A/NCOA4	1.25713171467007
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	13/1002	90/9376	1.35160789532047	PRKACB/FOXO1/PPARG/RPS6KB2/PRKAA2/PIK3CB/EHMT2/SESN1/CAMKK2/PIK3R3/EIF4EBP1/IRS1/MTOR	1.15936064586197
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	8/1002	51/9376	1.46780947908105	GNAS/PRKACB/ATP6V1C2/PLCG2/TJP1/ATP6V1H/ATP6V0D1/ATP6V1D	1.15873121360411
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	5/1002	28/9376	1.67094382663245	HADH/MECR/ACOT4/TECR/HSD17B12	1.22986897435754
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	11/1002	75/9376	1.37240186294079	GAPDH/BCAT2/PFKP/ACO2/ASL/SHMT1/GPT2/PHGDH/ALDOC/ALDH18A1/CTH	1.12003262968912
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	9/1002	59/9376	1.42738252308941	CTNNA1/GRB2/PIK3CB/GADD45B/MAPK3/DDB2/PIK3R3/CASP9/ERBB2	1.13908920832655
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	10/1002	67/9376	1.39660976554354	GAPDH/AKR1A1/FBP1/ALDH3A2/ALDH3B2/PFKP/BPGM/ALDOC/HK1/ADH1C	1.12694393425793
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	16/1002	117/9376	1.27962877663476	MTA1/BAZ2B/INO80C/BRD8/SMARCC1/ZNHIT1/MCRS1/SMARCA2/UCHL5/BRD7/BAZ1B/MORF4L1/INO80B/BRD9/BAZ2A/SMARCA1	1.05279974769108
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	5/1002	29/9376	1.61332507398995	SAV1/MOB1B/RASSF6/PAK1/NF2	1.14421231628452
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	11/1002	77/9376	1.33675506130596	RALB/RPS6KB2/PIK3CB/GADD45B/MAPK3/DDB2/CHUK/PIK3R3/CASP9/ERBB2/MTOR	1.02634741105186
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	24/1002	187/9376	1.20093502833904	PKN2/CASP4/TRIP6/RIPK2/GABARAPL1/TXNIP/MFN1/MAP1LC3B/MAP1LC3A/GBP3/IRAK4/OAS1/BRCC3/MAPK3/CASP1/IL18/CHUK/CASP8/FADD/CARD16/CARD6/RNASEL/RIPK3/NLRX1	0.960053313043098
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	6/1002	37/9376	1.51739763715812	HGD/MIF/ALDH3B2/FAHD1/LRTOMT/ADH1C	1.09075731971699
Human Diseases	Infectious disease: viral	hsa05162	Measles	18/1002	136/9376	1.23846424797464	CDKN1B/CSNK2A1/CYCS/EIF3H/HSPA1B/IRAK4/PIK3CB/RACK1/OAS1/CCNE1/CHUK/PIK3R3/CASP8/RCHY1/FADD/CASP9/APAF1/BBC3	0.96896873768929
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	14/1002	103/9376	1.27186403891247	WDR82/PPP2R1B/ETF1/UPF3A/TARDBP/PABPC1/HBS1L/UPF3B/UPF1/UPF2/DDX19B/PABPC4L/PCF11/SMG6	0.959650884223255
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	8/1002	54/9376	1.38626450802099	AMD1/MTAP/BCAT2/APIP/DNMT1/PHGDH/LACC1/CTH	0.984646079540834
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	6/1002	38/9376	1.4774661203908	ENPP3/QPRT/NAPRT/SIRT7/SIRT2/NUDT12	1.02014156961987
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	22/1002	173/9376	1.18994381179837	SLC25A6/SLC25A4/NUP98/CYCS/TRIM25/IRAK4/PIK3CB/EP300/OAS1/MAPK3/FDPS/CASP1/IL18/CHUK/PIK3R3/CASP8/FADD/TNFSF10/CASP9/APAF1/RNASEL/NLRX1	0.872241027003034
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	10/1002	71/9376	1.31792752523123	ATP6V1C2/PLCG2/TJP1/ATP6V1H/ATP6V0D1/ATP6V1D/PAK1/CHUK/F11R/MET	0.930148169650711
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	10/1002	71/9376	1.31792752523123	PFKP/PIK3CB/G6PD/MAPK3/PIK3R3/HK1/FGFR2/ERBB2/MET/MTOR	0.930148169650711
Genetic Information Processing	Transcription	hsa03040	Spliceosome	30/1002	243/9376	1.15522042335083	SYF2/SNRPD1/XAB2/CWC15/CCDC12/DDX46/CDC5L/LSM3/SNRPA1/PHF5A/LSM4/PRPF6/SNW1/DHX16/HSPA1B/SRSF8/WBP11/RBMX2/ZMAT2/DDX23/DHX8/YJU2/SNRPG/CTNNBL1/DHX38/PPIL1/SNIP1/THOC5/PRPF3/SF3A2	0.848004764358463
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	16/1002	122/9376	1.22718497431367	PPP2R1B/FBP1/FOXO1/CPT1A/PPARG/PFKP/RPS6KB2/PRKAA2/PIK3CB/CD36/MLYCD/CAMKK2/PIK3R3/EIF4EBP1/IRS1/MTOR	0.873670743560655
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	5/1002	31/9376	1.50923958534544	FBP1/PFKP/G6PD/DERA/ALDOC	0.982350273927628
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	5/1002	31/9376	1.50923958534544	ALDH3A2/ALDH3B2/MLYCD/EHHADH/ACOX3	0.982350273927628
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	7/1002	47/9376	1.39363825540409	PIK3CB/MAPK3/PIK3R3/HK1/SOCS4/IRS1/MTOR	0.935797113957615
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	6/1002	39/9376	1.43958237371411	ALDH1L2/GCSH/SHMT1/MTHFD2L/AMT/CTH	0.951528749600225
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	19/1002	150/9376	1.18525615435795	CSNK1A1/CDKN1B/RPS6KB2/CTNNA1/GRB2/JUP/PIK3CB/GADD45B/MAPK3/CCNE1/DDB2/CDKN2B/PIK3R3/FGFR2/ERBB2/FZD6/MET/RXRB/MTOR	0.791160451402663
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	5/1002	32/9376	1.46207584830339	GALE/PFKP/GALK1/HK1/GLB1	0.905680181563257
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	3/1002	17/9376	1.65128566396619	PSTK/TXNRD2/CTH	0.929681687262255
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	7/1002	50/9376	1.31001996007984	AMD1/ALDH3A2/CKB/SAT2/AGMAT/GAMT/ALDH18A1	0.760291216691413
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	14/1002	110/9376	1.19092723643622	ID1/ID3/PPP2R1B/SMAD9/GREM2/ROCK1/RPS6KB2/ID2/TFDP1/EP300/MAPK3/SKIL/CDKN2B/ZFYVE9	0.696740573658901
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	11/1002	85/9376	1.21094282024187	ENPP3/GUK1/NME3/DTYMK/GMPR2/ENTPD8/GDA/AK7/APRT/NME6/LACC1	0.675765477796006
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	3/1002	18/9376	1.55954757152362	HEXA/AGA/GLB1	0.821929878444873
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	8/1002	60/9376	1.2476380572189	SPHK1/PLA2G4A/PLCG2/HSPB1/PIK3CB/MAPK3/PIK3R3/CASP9	0.665627558068768
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	35/1002	300/9376	1.09168330006653	RPS6KA5/MAP2K6/DUSP2/PLA2G4A/MAP3K8/DUSP1/PRKACB/MAP3K13/HSPB1/MAP4K3/MAP3K4/RPS6KA2/MAPK8IP1/MECOM/MKNK2/MAP3K20/HSPA1B/IRAK4/GRB2/JUND/PAK1/GADD45B/DUSP8/MAPK3/ECSIT/TAOK3/DUSP3/CHUK/DUSP4/FGFR2/ERBB2/MAPT/MET/MAP2K7/ARTN	0.558285876764613
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	5/1002	35/9376	1.33675506130596	SORD/FBP1/PFKP/ALDOC/HK1	0.690405891229428
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	15/1002	122/9376	1.15048591341906	PRKACB/PLCG2/MDM2/FOXO1/PFKP/PIK3CB/EP300/MAPK3/PIK3R3/CASP9/PLCE1/MED27/NOTCH2/RXRB/MTOR	0.578714064472916
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	9/1002	70/9376	1.20307955517536	ACSL1/CPT1A/PRKAA2/CD36/CHUK/CAMKK2/IRS1/RXRB/MTOR	0.589911306397888
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	3/1002	19/9376	1.4774661203908	HEXA/HYAL3/GLB1	0.720616276322582
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	5/1002	36/9376	1.29962297626968	ENPP3/GBE1/PYGB/AGL/HK1	0.623025678285683
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	5/1002	36/9376	1.29962297626968	ST6GALNAC1/GALNT1/GALNT11/GALNT9/B3GNT3	0.623025678285683
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	4/1002	28/9376	1.33675506130596	CA2/ATP6V1C2/ATP6V0D1/ATP6V1D	0.61728655279059
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	20/1002	170/9376	1.10085710931079	PLCG2/CSNK1A1/RPS6KB2/SMARCC1/MGST2/GSTP1/GRB2/SMARCA2/PIK3CB/GADD45B/BRD7/MAPK3/GSTM4/DDB2/PIK3R3/TXNRD2/FZD6/MET/GSTA4/MTOR	0.459037866791433
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	12/1002	99/9376	1.13421641565354	GNAS/PRKACB/MDM2/CDKN1B/RPS6KB2/GRB2/PIK3CB/MAPK3/PIK3R3/NOTCH2/ERBB2/MTOR	0.464378897554826
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	12/1002	99/9376	1.13421641565354	PLA2G4A/CHKA/SLC44A1/RPS6KB2/GRB2/PLPP2/PIK3CB/CHKB/MAPK3/PIK3R3/EIF4EBP1/MTOR	0.464378897554826
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	6/1002	46/9376	1.22051549075762	FTH1/BLVRB/UGT2B7/ALAS1/PPOX/COX15	0.518597259963261
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	5/1002	38/9376	1.23122176699233	GALE/GALK1/HEXA/HK1/AMDHD2	0.494022353076642
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	18/1002	156/9376	1.07968678028558	PPP2R1B/CLDN4/CYCS/YWHAB/GRB2/PIK3CB/OAS1/CLDN15/MAPK3/CHUK/PIK3R3/CASP8/FADD/CASP9/CLDN1/APAF1/RNASEL/NR1H3	0.347165163393235
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	8/1002	66/9376	1.13421641565354	HSD17B8/DHRS11/HSD11B1L/UGT2B7/LRTOMT/HSD11B2/SULT1E1/HSD17B12	0.378491198204337
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	18/1002	157/9376	1.07280979442389	MAP2K6/MDM2/SLC25A6/FOXO1/SLC25A4/NBN/PIK3CB/GADD45B/MAPK3/CCNE1/TRAF3IP2/LIN37/HUS1/CDKN2B/PIK3R3/EIF4EBP1/CCNB1/MTOR	0.318237053131669
Human Diseases	Cancer: specific types	hsa05214	Glioma	9/1002	76/9376	1.1080995902931	PLCG2/MDM2/GRB2/PIK3CB/GADD45B/MAPK3/DDB2/PIK3R3/MTOR	0.327297275756759
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	23/1002	204/9376	1.05498806308951	PRKACB/PLCG2/RPS6/MDM2/EIF4B/RDX/ROCK1/RPS6KB2/CD44/GRB2/IQGAP1/PAK1/PPP1R12A/PIK3CB/MAPK3/PIK3R3/PLCE1/ERBB2/FZD6/SDC4/MET/MTOR/PPP1R12B	0.274665747519499
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	24/1002	214/9376	1.04941518831496	MAP2K6/PLCG2/WEE1/CUL5/CYCS/RPS6KB2/IRAK4/PAK1/PIK3CB/LIMK2/MAPK3/AP1S3/APOBEC3C/CHUK/AP1G1/PIK3R3/CASP8/GNG7/FADD/CASP9/CCNB1/MAP2K7/PAK6/MTOR	0.252944487067754
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	23/1002	205/9376	1.04984177985492	MAP2K6/PLCG2/MDM2/USP7/CDKN1B/CYCS/CD44/PSMC3/SNW1/IRAK4/ENTPD8/PIK3CB/GADD45B/OAS1/CCNE1/DDB2/CHUK/PIK3R3/CASP8/FADD/CASP9/APAF1/MAP2K7	0.249583084173616
NA	NA	hsa04517	IgSF CAM signaling	33/1002	299/9376	1.03274387679491	TUBB4B/MYL12B/MYL6/MYL6B/PLCG2/AFDN/MYL12A/TUBA1C/FOXO1/TJP1/RDX/NCK1/MYH14/ARPC1B/MBP/GRB2/IQGAP1/ICAM3/PAK1/TUBA1B/PIK3CB/MYH9/MAPK3/GRIP1/PIK3R3/CADM1/SLIT2/TUBA4A/EPB41L1/RAPGEF6/TUBB2A/F11R/PAK6	0.199043291420214
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	5/1002	41/9376	1.14113236940753	RPS6KA5/MDM2/MAPK3/DAPK3/ERBB2	0.31326683596555
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	8/1002	69/9376	1.08490265845121	MAP2K6/PLA2G4A/PLCG2/GRB2/PIK3CB/MAPK3/PIK3R3/MAP2K7	0.244846555124745
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	13/1002	116/9376	1.04866129809347	MYL12B/PLCG2/AFDN/MYL12A/CLDN4/ARHGAP5/ROCK1/CTNNA1/PIK3CB/CLDN15/PIK3R3/CLDN1/F11R	0.182414859064681
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	16/1002	144/9376	1.03969838101575	ID1/ID3/DLX5/POU5F1/SMAD9/REST/ID2/GRB2/PIK3CB/MAPK3/SKIL/ZFHX3/PIK3R3/FGFR2/FZD6/PCGF6	0.166057755869389
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	16/1002	144/9376	1.03969838101575	MAP2K6/LPIN2/FOXO1/ALDH3A2/CPT1A/PRKAA2/IRAK4/MLYCD/CHUK/CAMKK2/CASP8/LPIN3/FADD/ACOX3/MAP2K7/ADH1C	0.166057755869389
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	16/1002	144/9376	1.03969838101575	SLC25A6/SLC25A4/WIPI2/CYCS/OPA1/PSMC3/NRBF2/AFG3L2/PIK3CB/FGF14/ATG14/OMA1/PIK3R3/ULK2/PIK3R4/MTOR	0.166057755869389
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	12/1002	107/9376	1.04941518831496	GNAS/PRKACB/SIK2/FBP1/FOXO1/CPT1A/PPP4R3B/PFKP/PRKAA2/PPP4R3A/EP300/PYGB	0.1778234055096
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	11/1002	98/9376	1.05030754816897	SPHK1/PLA2G4A/PLCG2/RPS6KB2/ARPC1B/PAK1/PLPP2/PIK3CB/LIMK2/MAPK3/PIK3R3	0.173169748473576
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	10/1002	89/9376	1.05138038529682	GNAS/TUBB4B/PRKACB/TUBA1C/TJP1/GRB2/TUBA1B/MAPK3/TUBA4A/TUBB2A	0.168464213180285
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/1002	15/9376	1.2476380572189	HEXA/GLB1	0.332012867685647
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	15/1002	138/9376	1.01709624229801	MAP2K6/PKN2/RPS6KA2/ROCK1/ARPC1B/IRAK4/PIK3CB/ARHGEF28/MAPK3/CASP1/IL18/CHUK/PIK3R3/MAP2K7/GIT2	0.0699848843407149
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/1002	16/9376	1.16966067864271	MIF/ALDH3B2	0.234939633805906
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/1002	16/9376	1.16966067864271	FUT2/HEXA	0.234939633805906
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	4/1002	36/9376	1.03969838101575	SORD/DCXR/AKR1A1/UGT2B7	0.0825474436810788
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	13/1002	122/9376	0.997087791629855	MAP3K8/PPP2R1B/MALT1/NCK1/GRB2/PAK1/TEC1/PIK3CB/MAPK3/CHUK/PIK3R3/MAP2K7/PAK6	-0.0111992937025633
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/1002	17/9376	1.10085710931079	CA2/CA8	0.143969094890622
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/1002	17/9376	1.10085710931079	MYH14/MYH9	0.143969094890622
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	3/1002	27/9376	1.03969838101575	HADH/OXCT1/EHHADH	0.0714537652022966
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	4/1002	37/9376	1.01159842477208	RIMKLB/ASRGL1/ASL/GPT2	0.0244513422728757
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	11/1002	105/9376	0.980287044957704	PLCG2/MDM2/MALT1/KSR1/PAK1/PIK3CB/MAPK3/CASP1/CHUK/PIK3R3/CASP8	-0.0702645244230752
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	14/1002	134/9376	0.977626835880478	GNAS/PLA2G4A/MYL6/MYL6B/PRKACB/ACTG2/MYH14/ROCK1/PPP1R12A/GNA13/MYH9/ADM/MAPK3/PPP1R12B	-0.090229769144724
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	17/1002	163/9376	0.975913204266314	MAP2K6/CYCS/IRAK4/YWHAB/GRB2/PIK3CB/EP300/MAPK3/CCNE1/DDB2/CHUK/PIK3R3/CASP8/FADD/CASP9/APAF1/MAP2K7	-0.107306323873647
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	3/1002	28/9376	1.00256629597947	MOCOS/QDPR/MOCS2	0.00470413122363712
Organismal Systems	Immune system	hsa04611	Platelet activation	13/1002	126/9376	0.965434210943193	GNAS/PLA2G4A/MYL12B/PRKACB/PLCG2/MYL12A/ROCK1/PPP1R12A/PIK3CB/GNA13/MAPK3/PIK3R3/VAMP8	-0.135118215889181
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	16/1002	155/9376	0.96591333462108	TUBB4B/DYNC1I1/STX18/ATP6V1C2/TUBA1C/ATP6V1H/DYNC1LI2/ATP6V0D1/ATP6V1D/EEA1/STX7/TUBA1B/CD36/RILP/TUBA4A/TUBB2A	-0.148017946914378
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	24/1002	232/9376	0.967995044393971	RGCC/IQGAP2/MYL12B/MYL12A/RDX/MYH14/ROCK1/ARPC1B/IQGAP1/PAK1/PPP1R12A/PIK3CB/GNA13/DIAPH2/LIMK2/MYH9/MAPK3/PIK3R3/SSH3/SPATA13/FGFR2/PIP4K2C/PAK6/PPP1R12B	-0.17074426820572
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	8/1002	78/9376	0.959721582476074	PLCG2/PIK3C2A/PIK3CB/IPMK/FIG4/PLCE1/INPP5J/PIP4K2C	-0.123560014494373
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	8/1002	78/9376	0.959721582476074	SEPTIN11/CLTB/CTNNA1/ARPC1B/SEPTIN8/PIK3CB/PIK3R3/MET	-0.123560014494373
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/1002	29/9376	0.967995044393971	CNGA1/RGS9/PDE6A	-0.0597080829393222
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	6/1002	59/9376	0.951588348726276	ENPP3/NME3/DTYMK/ENTPD8/NME6/CDADC1	-0.129030052807353
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	6/1002	59/9376	0.951588348726276	GPX4/MGST2/GSTP1/G6PD/GSTM4/GSTA4	-0.129030052807353
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	6/1002	59/9376	0.951588348726276	GNAS/PRKACB/MGLL/PIK3CB/PIK3R3/IRS1	-0.129030052807353
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	8/1002	79/9376	0.947573208014351	ALDH3B2/MGST2/GSTP1/HSD11B1L/UGT2B7/GSTM4/GSTA4/ADH1C	-0.161863316542989
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	16/1002	157/9376	0.95360870615457	SGK1/DUSP2/SPHK1/CPT1A/PPARG/NR1H2/UQCRFS1/CD36/DUSP8/MAPK3/CASP1/DUSP4/VPS41/VPS16/RAB17/NR1H3	-0.202767069473976
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	13/1002	128/9376	0.950349301397206	ENPP3/GUK1/NME3/HDDC3/GMPR2/ENTPD8/GDA/AK7/APRT/PDE6A/NME6/LACC1/PDE6D	-0.195640812832414
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	11/1002	109/9376	0.944313208445494	MAP2K6/MAP3K8/IRAK4/PIK3CB/MAPK3/CHUK/PIK3R3/CASP8/FADD/MAP2K7/TLR5	-0.20227810877319
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	7/1002	70/9376	0.935728542914172	MGST2/GSTP1/HSD11B1L/UGT2B7/GSTM4/SULT1A1/GSTA4	-0.186697568747661
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	3/1002	30/9376	0.935728542914172	OGDH/ACO2/FH	-0.121960418382136
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	3/1002	30/9376	0.935728542914172	PIGZ/PIGC/PIGA	-0.121960418382136
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	11/1002	110/9376	0.935728542914172	PRKACB/RPS6KA2/ANAPC11/PIK3CB/ANAPC16/MAPK3/ANAPC7/PIK3R3/AURKA/CCNB1/ANAPC1	-0.234542398013669
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	12/1002	120/9376	0.935728542914172	RPS6KA5/PLCG2/RPS6KA2/RIPK2/IRAK4/GRB2/PIK3CB/MAPK3/PIK3R3/ZNF274/IRS1/MAP2K7	-0.245103840702974
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	3/1002	31/9376	0.905543751207263	AKR1A1/ALDH3A2/UGT2B7	-0.182211133120727
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	8/1002	82/9376	0.912905895526021	NME3/MGST2/GSTP1/UGT2B7/GSTM4/NME6/CDADC1/GSTA4	-0.273997986128073
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	6/1002	62/9376	0.905543751207263	TLE1/SNW1/EP300/TLE6/NOTCH2/TLE2	-0.258113929654527
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	18/1002	181/9376	0.930558771958845	SPHK1/RIPK2/MALT1/CYCS/ATP6V1H/ATP6V0D1/EEA1/KSR1/IRAK4/RFXANK/EP300/MAPK3/CTSD/IL18/CASP8/FADD/CASP9/APAF1	-0.326312592677752
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	14/1002	142/9376	0.922549267661859	MAP2K6/DUSP1/MGST2/PRKAA2/GSTP1/SUMO3/PIK3CB/GSTM4/CHUK/PIK3R3/PIAS4/SDC4/GSTA4/MAP2K7	-0.321682760049814
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	4/1002	42/9376	0.89117004087064	HADH/IDO2/ALDH3A2/EHHADH	-0.244507527313951
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	10/1002	103/9376	0.908474313508905	GNAS/PPP2R1B/IRAK4/PIK3CB/MAPK3/CHUK/PIK3R3/CASP8/FADD/ACE	-0.323075851891541
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	7/1002	73/9376	0.897273945260164	ALDH3B2/MGST2/GSTP1/UGT2B7/GSTM4/GSTA4/ADH1C	-0.304777954050186
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	7/1002	73/9376	0.897273945260164	PPIA/EP300/BICD1/MLLT3/APOBEC3C/PDCD6IP/BICD2	-0.304777954050186
Human Diseases	Cancer: specific types	hsa05218	Melanoma	7/1002	73/9376	0.897273945260164	MDM2/PIK3CB/GADD45B/MAPK3/DDB2/PIK3R3/MET	-0.304777954050186
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/1002	22/9376	0.850662311740156	ALDH3A2/ALDH3B2	-0.242568890911186
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	20/1002	205/9376	0.912905895526021	PRKACB/MDM2/USP7/GTF2A1/CDKN1B/UBE3A/ATP6V0D1/MRPS18B/SNW1/YWHAB/GRB2/PIK3CB/EP300/MAPK3/CCNE1/CDKN2B/PIK3R3/CASP8/GTF2H3/HDAC10	-0.436124377404376
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	33/1002	333/9376	0.927298556041071	GNAS/PRKACB/ATP6V1C2/PPP2R1B/MDM2/FOXO1/CSNK1A1/CDKN1B/UBE3A/ATP6V1H/TADA3/ATP6V0D1/ATP6V1D/RPS6KB2/GRB2/NFX1/PIK3CB/EP300/MAPK3/TUBG1/CCNE1/CHUK/PIK3R3/CASP8/FADD/EIF4EBP1/NOTCH2/FZD6/LAMB4/HES2/MTOR/COL9A3/DLG3	-0.467263554867815
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	4/1002	44/9376	0.850662311740156	RPN1/MAN1A2/HEXA/B4GALNT3	-0.343448337175985
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	4/1002	44/9376	0.850662311740156	GNAS/DYNC1I1/PRKACB/DYNC1LI2	-0.343448337175985
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	6/1002	65/9376	0.863749424228466	LPIN2/AKR1A1/ALDH3A2/MGLL/PLPP2/LPIN3	-0.38128514197135
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	21/1002	216/9376	0.909736083388778	MAP2K6/PPARG/HSPA2/CYCS/HSPA1B/IRAK4/HSPA4/PIK3CB/CD36/MAPK3/CASP1/IL18/POU2F3/CHUK/PIK3R3/CASP8/TNFSF10/CASP9/APAF1/MAP2K7/RXRB	-0.46424403615792
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	5/1002	55/9376	0.850662311740156	SPHK1/PLPP2/HEXA/CERK/GLB1	-0.384213424943007
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/1002	23/9376	0.81367699383841	ASL/GPT2	-0.309462446131547
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/1002	23/9376	0.81367699383841	NLN/ACE	-0.309462446131547
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	16/1002	168/9376	0.89117004087064	PLA2G4A/PPIA/FTH1/SLC25A6/SLC25A4/CHMP4C/CHMP3/PARP1/PYGB/CASP1/CHMP2A/CASP8/FADD/TNFSF10/SPATA2L/RIPK3	-0.492349467238847
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	13/1002	138/9376	0.881483409991611	PRKACB/PPP2R1B/RPS6KA2/ANAPC11/YWHAB/ANAPC16/SMC1A/MAPK3/CCNE1/ANAPC7/AURKA/CCNB1/ANAPC1	-0.485157480784954
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	23/1002	238/9376	0.904275482648149	PLA2G4A/PRKACB/PLCG2/AFDN/ETS2/RALB/RALGAPA2/SHOC2/KSR1/GRB2/PAK1/PIK3CB/KSR2/MAPK3/CHUK/PIK3R3/GNG7/BRAP/RASAL1/PLCE1/FGFR2/MET/PAK6	-0.517415110523818
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	11/1002	119/9376	0.864959157315621	RPS6KA5/MAP2K6/MAP3K8/PIK3CB/MAPK3/CHUK/PIK3R3/CASP8/FADD/MAP2K7/RIPK3	-0.512810027621842
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	17/1002	180/9376	0.883743623863384	ZC3HAV1/CYCS/IRAK4/SRSF8/EIF2B5/PIK3CB/OAS1/POU2F3/CHUK/PIK3R3/CASP8/FADD/CASP9/EIF4EBP1/APAF1/RNASEL/MTOR	-0.544761708481899
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	19/1002	201/9376	0.884519518177575	MDM2/HPGD/FOXO1/PPARG/CDKN1B/KLF3/ID2/PER2/MLF1/JUP/ASPSCR1/GADD45B/MLLT3/SPINT1/DDB2/RUNX1/MET/RXRB/NSD2	-0.572475098064355
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	7/1002	79/9376	0.829126557012557	ATP6V1C2/ATP6V1H/CLTB/ATP6V0D1/ATP6V1D/STX3/STXBP1	-0.527557402303728
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	8/1002	90/9376	0.831758704812597	MAP2K6/CSNK2A1/RPS6KB2/PIK3CB/MAPK3/CHUK/PIK3R3/MTOR	-0.554743904346467
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	11/1002	122/9376	0.843689669840647	GNAS/MAP2K6/PRKACB/PLCG2/GRB2/PIK3CB/EP300/MAPK3/PIK3R3/IRS1/MTOR	-0.601112651878042
NA	NA	hsa03272	Virion - Hepatitis viruses	4/1002	48/9376	0.77977378576181	CLDN4/CLDN15/PDCD6IP/CLDN1	-0.529112941313108
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/1002	13/9376	0.719791186857055	XRCC4	-0.349702692209555
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	8/1002	91/9376	0.822618499265206	PLCG2/MALT1/GRB2/PIK3CB/MAPK3/CHUK/PIK3R3/DAPP1	-0.588154044360909
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	3/1002	37/9376	0.758698818579058	GALE/GALK1/HK1	-0.508701646449179
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/1002	26/9376	0.719791186857055	PLA2G4A/ACOX3	-0.494897978494031
Organismal Systems	Nervous system	hsa04730	Long-term depression	5/1002	60/9376	0.77977378576181	GNAS/PLA2G4A/PPP2R1B/GNA13/MAPK3	-0.591947129824724
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	18/1002	196/9376	0.859342539410974	MAP2K6/UBA52/PLCG2/CYCS/MAP1LC3B/MAP1LC3A/PIK3CB/EP300/MAPK3/ATG14/CHUK/PIK3R3/CASP8/GNG7/FADD/CASP9/MAP2K7/MTOR	-0.688370876889885
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	8/1002	93/9376	0.8049277788509	GNAS/MAP2K6/PLA2G4A/PRKACB/MAP3K4/GRB2/MAPK3/MAP2K7	-0.653951813900548
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	6/1002	72/9376	0.77977378576181	SIKE1/TRIM25/CHUK/CASP8/FADD/NLRX1	-0.64886362909719
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	8/1002	94/9376	0.796364717373763	USP25/JUND/TRAF4/MAPK3/TRAF3IP2/CHUK/CASP8/FADD	-0.686355618479766
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	9/1002	105/9376	0.802053036783576	PLCG2/MALT1/CSNK2A1/TRIM25/IRAK4/PARP1/GADD45B/CHUK/PIAS4	-0.705558816603167
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/1002	15/9376	0.623819028609448	AK7	-0.50435270120759
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/1002	28/9376	0.66837753065298	FUT2/B3GNT3	-0.607878290343316
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	4/1002	52/9376	0.719791186857055	GNAS/PLA2G4A/PRKACB/ACOT4	-0.700866578458231
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	4/1002	52/9376	0.719791186857055	MYLIP/CD36/NCEH1/CIDEB	-0.700866578458231
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	12/1002	139/9376	0.807823202515832	GNAS/KRT23/KRT18/PRKACB/KRT19/HSPA1B/GRB2/PIK3CB/MAPK3/CTSD/PIK3R3/KRT15	-0.789579566730988
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	7/1002	86/9376	0.761639511674326	DSP/PKP2/LMNA/CTNNA1/SGCD/JUP/DSC2	-0.768119261682976
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	12/1002	140/9376	0.802053036783576	SPHK1/PRKACB/RPS6/RPS6KB2/PRKAA2/MAP1LC3B/MAP1LC3A/GNA13/MAPK3/GNG7/PIK3R4/MTOR	-0.816251363708896
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	8/1002	98/9376	0.763860035031977	PLCG2/PIK3C2A/PIK3CB/IPMK/PIP4P1/PIK3R3/PLCE1/PIP4K2C	-0.812846179677179
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	15/1002	174/9376	0.806662536994976	ERP29/CRYAB/UBE2D2/SVIP/RPN1/UBE2D4/STUB1/HSPA1B/MAN1A2/HSPBP1/UBXN2A/NGLY1/PRKCSH/MAP2K7/WFS1	-0.890435663242427
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/1002	30/9376	0.623819028609448	SHMT1/CHUK	-0.713834581296686
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	19/1002	217/9376	0.819301489187524	GNAS/AHR/PRKACB/KLF5/RPS6KA2/KPNA4/RPS6KB2/MGST2/GRB2/PIK3CB/UGT2B7/MAPK3/GSTM4/PIK3R3/EIF4EBP1/NOTCH2/GSTA4/RXRB/MTOR	-0.9315655755567
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	3/1002	43/9376	0.652833867149422	SLC27A4/PLPP2/CD36	-0.78924886740603
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	9/1002	112/9376	0.751924721984602	MAP2K6/CYCS/HSPA1B/IRAK4/MAPK3/CHUK/CASP8/CASP9/LAMB4	-0.913579289180544
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	4/1002	56/9376	0.66837753065298	DPM3/RPN1/DPM1/MAN1A2	-0.860960103400817
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	4/1002	56/9376	0.66837753065298	PRKACB/CSNK1A1/CUL3/CSNK1G1	-0.860960103400817
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/1002	18/9376	0.519849190507873	MMUT	-0.705302491808621
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	12/1002	148/9376	0.758698818579058	CSNK1A1/RPS6KB2/GRB2/PIK3CB/GADD45B/MAPK3/DDB2/PIK3R3/NOTCH2/ERBB2/FZD6/MTOR	-1.02350397504831
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	12/1002	149/9376	0.753606880199333	GNAS/SPHK1/PLA2G4A/PLCG2/RALB/GRB2/PLPP2/PIK3CB/GNA13/MAPK3/PIK3R3/MTOR	-1.04868358763561
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	17/1002	203/9376	0.783615035937976	MYL12B/MYL12A/FLNB/ARHGAP5/ROCK1/GRB2/PAK1/PPP1R12A/PIK3CB/MAPK3/PIK3R3/ERBB2/MET/PAK6/LAMB4/COL9A3/PPP1R12B	-1.07813320661472
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	5/1002	71/9376	0.658963762615614	GRB2/PIK3CB/MAPK3/PIK3R3/SOCS4	-0.997756428157465
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/1002	20/9376	0.467864271457086	CYP2R1	-0.824034379323433
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/1002	20/9376	0.467864271457086	CYB5RL	-0.824034379323433
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	15/1002	184/9376	0.762822181723509	MYL12B/PLCG2/MYL12A/NCK1/ROCK1/PAK1/PIK3CB/LIMK2/MAPK3/PIK3R3/SSH3/SLIT2/MET/PAK6/EPHB6	-1.12390859940127
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	19/1002	227/9376	0.783208912571333	GNAS/MAP2K6/PRKACB/MDM2/CYCS/ROCK1/RPS6KB2/GRB2/PIK3CB/GNA13/MAPK3/CHUK/PIK3R3/CASP8/GNG7/FADD/CASP9/EIF4EBP1/MTOR	-1.14372222189518
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	3/1002	48/9376	0.584830339321357	PIK3CB/PIK3R3/HK1	-0.997481798729243
NA	NA	hsa04382	Cornified envelope formation	18/1002	217/9376	0.776180358177654	KRT23/KRT8/DSP/KRT18/PPP2R1B/SLC27A4/KRT19/KRT80/CLDN4/S100A13/TJP1/PKP2/JUP/S100A2/CLDN15/CLDN1/KRT15/PLEC	-1.15387045813292
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	11/1002	142/9376	0.724860138877175	MAP2K6/PLCG2/PPARG/GRB2/JUND/TEC1/PIK3CB/MAPK3/CHUK/PIK3R3/MAP2K7	-1.14276195012978
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	7/1002	97/9376	0.675268020659711	GNAS/RPS6KA5/PRKACB/PER2/MAPK3/GNG7/NOS1AP	-1.1120219509396
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/1002	21/9376	0.44558502043532	B3GALT6	-0.879783328363798
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	3/1002	49/9376	0.572895026273983	GALNT1/GALNT11/GALNT9	-1.03684706159497
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	3/1002	49/9376	0.572895026273983	GNAS/PRKACB/RGS9	-1.03684706159497
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	12/1002	155/9376	0.72443500096581	GNAS/AHR/PRKACB/CDKN1B/USP8/FH/MAPK3/CCNE1/ASH2L/CDKN2B/NCEH1/FZD6	-1.19661354213101
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	3/1002	50/9376	0.561437125748503	CD36/IL18/MET	-1.07552914068656
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	7/1002	99/9376	0.661626242464566	GNAS/MAP2K6/PLA2G4A/PRKACB/PLCG2/PIK3CB/PIK3R3	-1.17074824059826
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	4/1002	63/9376	0.594113360580426	PLA2G4A/HPGD/PTGR1/GPX4	-1.11810669978256
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	2/1002	37/9376	0.505799212386039	IDO2/IL18	-1.04185463517123
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	19/1002	233/9376	0.763040442719711	DSP/PDLIM1/ACTG2/PKP2/MYH14/SUN1/LMNA/PDLIM5/SGCD/TPM4/JUP/DIAPH2/MYOM1/MYH9/DSC2/FMNL2/SDC4/PLEC/COL9A3	-1.26695401192547
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/1002	51/9376	0.550428554655395	PLA2G4A/PAFAH1B1/PLPP2	-1.11355688535685
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	12/1002	157/9376	0.715206529615927	ID1/SAV1/PPP2R1B/MOB1B/ID2/CTNNA1/RASSF6/YWHAB/BBC3/FZD6/NF2/DLG3	-1.24477531468527
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	6/1002	89/9376	0.630828231178093	CD44/CD36/FREM2/SDC4/LAMB4/COL9A3	-1.21042750465328
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	2/1002	38/9376	0.492488706796932	RFXANK/UNG	-1.08433529655305
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	7/1002	101/9376	0.648524732712792	PLCG2/FOXO1/CDKN1B/PIK3CB/MAPK3/PIK3R3/PLCE1	-1.22843312364683
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/1002	23/9376	0.406838496919205	RXYLT1	-0.985177372756928
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/1002	23/9376	0.406838496919205	CA2	-0.985177372756928
Organismal Systems	Digestive system	hsa04976	Bile secretion	6/1002	90/9376	0.623819028609448	GNAS/CA2/PRKACB/SLC27A5/UGT2B7/NCEH1	-1.24038572442984
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	3/1002	53/9376	0.529657665800475	GNAS/PRKACB/CLTB	-1.1877558647927
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/1002	24/9376	0.389886892880905	B3GALT6	-1.03518208528317
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	14/1002	183/9376	0.715857901682973	NHP2/POP5/CSNK2A1/RPP25L/RPP30/GTPBP4/FCF1/GNL3L/BMS1/NOP58/NMD3/EFL1/REXO1/RMRP	-1.34272018842348
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	8/1002	115/9376	0.650941595070728	GNAS/SGK1/PRKACB/JUND/OXSR1/GNA13/MAPK3/RXRB	-1.30278004739976
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	4/1002	67/9376	0.558643906217416	PRKACB/RPS6KA2/EP300/MAPK3	-1.25408806324879
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	7/1002	104/9376	0.629817288499923	PLA2G4A/LPIN2/CHKA/PLPP2/CHKB/GPD2/LPIN3	-1.313103960007
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4/1002	68/9376	0.550428554655395	DHRS4L2/UGT2B7/RDH13/ADH1C	-1.28699840547408
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/1002	26/9376	0.359895593428528	FOXA2	-1.13053680676253
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	11/1002	154/9376	0.66837753065298	GNAS/PLA2G4A/MYL6/MYL6B/PRKACB/ROCK1/PRKAA2/PPP1R12A/MAPK3/CAMKK2/PPP1R12B	-1.43530689456471
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	4/1002	70/9376	0.534702024522384	CYCS/SGCD/CASP8/CASP9	-1.35161088146598
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	8/1002	125/9376	0.59886626746507	SPHK1/PPP2R1B/ROCK1/PIK3CB/GNA13/MAPK3/CTSD/PIK3R3	-1.56171891858869
NA	NA	hsa04519	Cadherin signaling	33/1002	404/9376	0.764332720697219	LIMA1/KRT23/KRT8/DSP/KRT18/AFDN/SAV1/KRT19/KRT80/TJP1/CSNK1A1/PKP2/SHOC2/MOB1B/ROCK1/CTNNA1/ARPC1B/YWHAB/JUP/EP300/MAPK3/TAOK3/MYO1E/CHUK/DSC2/AMOTL2/KRT15/AMOTL1/ERBB2/FZD6/MET/NF2/ATN1	-1.6749365466176
Organismal Systems	Digestive system	hsa04978	Mineral absorption	3/1002	61/9376	0.460194365367625	FTH1/ATOX1/SLC26A3	-1.46306601409859
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	29/1002	362/9376	0.749616788522403	SGK1/PKN2/PPP2R1B/RPS6/MDM2/EIF4B/PKN3/CDKN1B/RPS6KB2/PRKAA2/YWHAB/GRB2/SGK3/PIK3CB/MAPK3/CCNE1/CHUK/PIK3R3/GNG7/CASP9/EIF4EBP1/FGFR2/ERBB2/IRS1/MET/LAMB4/ARTN/MTOR/COL9A3	-1.6805588861518
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	4/1002	75/9376	0.499055222887558	GNAS/PRKACB/TTF1/IYD	-1.50663718921163
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/1002	30/9376	0.311909514304724	PLA2G4A	-1.30570874421124
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	4/1002	76/9376	0.492488706796932	GNAS/CA2/PRKACB/SLC9A4	-1.53661140833907
NA	NA	hsa04981	Folate transport and metabolism	1/1002	31/9376	0.301847917069088	SHMT1	-1.34677254016908
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	6/1002	103/9376	0.545084588105343	GNAS/PRKACB/HSPB1/PIK3CB/PIK3R3/LAMB4	-1.60580258800634
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	3/1002	63/9376	0.44558502043532	GADD45B/DDB2/FZD6	-1.5272616610331
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	7/1002	116/9376	0.564663775896483	GNAS/PLA2G4A/PRKACB/DLGAP1/HOMER2/MAPK3/GNG7	-1.63192925542307
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	16/1002	224/9376	0.66837753065298	PRKACB/ETS2/SLC25A6/SLC25A4/ANAPC11/PIK3CB/EP300/ANAPC16/MAPK3/FDPS/CCNE1/ANAPC7/CHUK/CDKN2B/PIK3R3/ANAPC1	-1.73765267386768
NA	NA	hsa04518	Integrin signaling	10/1002	154/9376	0.607615936957254	FLNB/ICAM3/PIK3CB/FREM2/PIK3R3/ERBB2/MET/LAMB4/MTOR/COL9A3	-1.6982912892227
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	8/1002	130/9376	0.575832949485644	GNAS/PRKACB/GRB2/PIK3CB/MAPK3/PIK3R3/GNG7/MAP2K7	-1.68455300827719
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	3/1002	65/9376	0.431874712114233	GNAS/PRKACB/NCEH1	-1.58984818832814
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	3/1002	65/9376	0.431874712114233	PIK3CB/MAPK3/PIK3R3	-1.58984818832814
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	5/1002	95/9376	0.492488706796932	ATP6V1C2/ATP6V1H/ATP6V0D1/ATP6V1D/IL18	-1.71974140528512
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	4/1002	82/9376	0.456452947763011	HSPA2/HSPA1B/RFXANK/HSPA4	-1.70999861102288
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	6/1002	109/9376	0.515079931879361	AHR/MAPK3/CHUK/RUNX1/RXRB/MTOR	-1.76143590872175
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	10/1002	160/9376	0.584830339321357	CLDN4/ALCAM/ICAM3/CLDN15/PTPRM/CADM1/NRXN3/CLDN1/F11R/SDC4	-1.83217683585936
Organismal Systems	Endocrine system	hsa04924	Renin secretion	3/1002	69/9376	0.406838496919205	GNAS/PRKACB/ACE	-1.71058896519008
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	5/1002	99/9376	0.472590173188976	LMNA/PRKAA2/SGCD/TPM4/ACE	-1.8247990958595
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	14/1002	212/9376	0.617933943433887	GNAS/ID1/MAP2K6/AFDN/SKAP1/RALB/PIK3CB/MAPK3/PIK3R3/PLCE1/RAPGEF6/FGFR2/MET/PRKD2	-1.94633174802819
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	11/1002	178/9376	0.578259211913252	PRKACB/TBL1XR1/CSNK1A1/CSNK2A1/TLE1/EP300/TLE6/SIAH1/FZD6/TLE2/RNF43	-1.96499714842253
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	5/1002	101/9376	0.463231951937709	GNAS/PRKACB/EP300/MAPK3/FZD6	-1.87604566046509
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	6/1002	115/9376	0.488206196303046	GNAS/PLA2G4A/DUSP1/PRKACB/MAPK3/GNG7	-1.91015241696965
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	5/1002	102/9376	0.458690462212829	GNAS/CA2/CPB2/RAB3D/SLC26A3	-1.90136388323352
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	12/1002	193/9376	0.58180013030933	PRKACB/PLCG2/ROCK1/GRB2/PAK1/PIK3CB/MAPK3/CCL28/CHUK/PIK3R3/GNG7/GRK6	-2.03059483036193
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	5/1002	105/9376	0.44558502043532	GNAS/PRKACB/LMNA/SGCD/TPM4	-1.97614740096335
Human Diseases	Substance dependence	hsa05032	Morphine addiction	4/1002	91/9376	0.411309249632603	GNAS/PRKACB/GNG7/GRK6	-1.95195578046277
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	7/1002	133/9376	0.492488706796932	PLCG2/GRB2/PAK1/PIK3CB/MAPK3/PIK3R3/TNFSF10	-2.03900398857629
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	3/1002	78/9376	0.359895593428528	IRAK4/MAPK3/CASP1	-1.96361512233942
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	3/1002	78/9376	0.359895593428528	EEF1A1/IRAK4/MAPK3	-1.96361512233942
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	1/1002	44/9376	0.212665577935039	ICA1	-1.81071972661798
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/1002	45/9376	0.207939676203149	ABCD3	-1.84227068655216
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	9/1002	166/9376	0.507322703989611	SLC25A6/SLC25A4/ROCK1/CNGA1/GTF2I/PPP1R12A/GNA13/MAPK3/IRS1	-2.21533698861243
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	1/1002	46/9376	0.203419248459603	PSMC3	-1.87335861834033
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	2/1002	66/9376	0.283554103913385	IL18/TLR5	-2.02038226351075
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	9/1002	168/9376	0.501283147989735	GRB2/PIK3CB/EP300/STAM/PIK3R3/SOCS4/PIAS4/CLCF1/MTOR	-2.25620755860457
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	4/1002	99/9376	0.37807213855118	KRT23/KRT18/KRT19/KRT15	-2.15182452349012
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	11/1002	195/9376	0.527846870361841	PLCG2/CASP4/SLC25A6/SLC25A4/HAT1/PIK3CB/MAPK3/CASP1/PIK3R3/HDAC10/MTOR	-2.30466711727203
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	5/1002	115/9376	0.406838496919205	PRKACB/PIK3CB/MAPK3/PIK3R3/GNG7	-2.2138386017546
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	2/1002	69/9376	0.271225664612803	GNAS/PRKACB	-2.10167606925305
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	3/1002	86/9376	0.326416933574711	GNAS/PRKACB/TRPM4	-2.17062874513762
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/1002	50/9376	0.187145708582834	CCL28	-1.99343931937555
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	4/1002	103/9376	0.363389725403562	COL25A1/COL28A1/CPB2/COL9A3	-2.24716595606373
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	6/1002	133/9376	0.422133177254513	GNAS/PRKACB/PPP2R1B/LRTOMT/CLOCK/GNG7	-2.32166805394122
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	13/1002	226/9376	0.538250931764789	GNAS/PRKACB/AFDN/ROCK1/CNGA1/PAK1/PPP1R12A/PIK3CB/EP300/MAPK3/PIK3R3/ACOX3/PLCE1	-2.43053971018944
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	3/1002	89/9376	0.315414115589047	PRKACB/GABARAPL1/GNG7	-2.24459629302846
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	3/1002	93/9376	0.301847917069088	MAPK3/CHUK/NOTCH2	-2.34045533660149
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	20/1002	323/9376	0.579398478584626	RPS6KA5/PLCG2/MDM2/RDX/CDKN1B/ROCK1/CD44/GRB2/FOXP1/PIK3CB/EP300/MAPK3/CCNE1/DNMT1/PIK3R3/NOTCH2/ERBB2/IRS1/MET/MTOR	-2.6609018837144
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	3/1002	98/9376	0.286447513136991	GNAS/PRKACB/PRKD2	-2.45620605992844
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	3/1002	100/9376	0.280718562874251	CCL28/IL18/TNFSF10	-2.50133294417858
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	6/1002	154/9376	0.364569562174353	GNAS/RPS6KA5/PRKACB/PPP2R1B/TPM4/MAPK3	-2.75022886785467
Organismal Systems	Digestive system	hsa04970	Salivary secretion	2/1002	93/9376	0.201231944712725	GNAS/PRKACB	-2.67775604114168
Human Diseases	Substance dependence	hsa05034	Alcoholism	8/1002	191/9376	0.391928185513789	GNAS/PRKACB/GRB2/HAT1/MAPK3/CAMKK2/GNG7/HDAC10	-2.93687185524318
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	12/1002	254/9376	0.442076476967325	GNAS/SPHK1/PRKACB/PLCG2/SLC25A6/SLC25A4/ORAI2/TFEB/PLCE1/FGFR2/ERBB2/MET	-3.11816805131881
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	2/1002	100/9376	0.187145708582834	CD44/CD36	-2.82673667495639
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/1002	86/9376	0.108805644524904	PRKACB	-2.87188348686494
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	1/1002	88/9376	0.10633278896752	CPB2	-2.91346011627709
NA	NA	hsa04081	Hormone signaling	8/1002	219/9376	0.341818645813396	GNAS/PRKACB/SMAD9/PIK3CB/GNA13/PIK3R3/GNG7/IRS1	-3.40913379491449
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	1/1002	143/9376	0.0654355624415505	SNRPD1	-3.8954611074907
NA	NA	hsa04082	Neuroactive ligand signaling	3/1002	199/9376	0.141064604459423	GNAS/PRKACB/GNG7	-4.23632911788804
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	6/1002	298/9376	0.188401720049833	CCL28/GDF15/IL18/TNFSF12/TNFSF10/CLCF1	-4.92501073507316
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	4/1002	370/9376	0.101159842477208	GAL/CHRNB1/ADM/GALP	-6.10197436200567
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/1002	449/9376	0.0416805587044174	PRKACB/GNG7	-7.1983626516706