ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003735 structural constituent of ribosome 58/2202 175/18639 0.331428571428571 2.80540288049825 7.39006734420474e-14 8.49118737849125e-11 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 28/2202 68/18639 0.411764705882353 3.48541432921943 7.6890702260821e-10 4.41737084488417e-07 GO:0008137 NADH dehydrogenase (ubiquinone) activity 19/2202 41/18639 0.463414634146341 3.92260915797169 4.07036687641119e-08 1.55895051366549e-05 GO:0003684 damaged DNA binding 26/2202 74/18639 0.351351351351351 2.97404079829148 1.4623427928277e-07 3.78943326219541e-05 GO:0003954 NADH dehydrogenase activity 19/2202 44/18639 0.431818181818182 3.65515853356453 1.64901360408851e-07 3.78943326219541e-05 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 22/2202 58/18639 0.379310344827586 3.21070186977356 2.83463953351779e-07 5.42833470668656e-05 GO:0015078 proton transmembrane transporter activity 46/2202 185/18639 0.248648648648649 2.10470579571397 6.04518014239698e-07 9.92273140516304e-05 GO:0009055 electron transfer activity 33/2202 116/18639 0.28448275862069 2.40802640233017 9.55411996990352e-07 0.000137221048067739 GO:0140098 catalytic activity, acting on RNA 78/2202 387/18639 0.201550387596899 1.70603890754705 1.37151692833896e-06 0.00017509699451794 GO:0003712 transcription coregulator activity 92/2202 495/18639 0.185858585858586 1.57321443315994 6.01792421837269e-06 0.000645448100100816 GO:0016651 oxidoreductase activity, acting on NAD(P)H 26/2202 88/18639 0.295454545454545 2.50089794401784 6.17922463107831e-06 0.000645448100100816 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 40/2202 167/18639 0.239520958083832 2.02744375010198 8.48832039431186e-06 0.000791817611315776 GO:0016741 transferase activity, transferring one-carbon groups 48/2202 215/18639 0.223255813953488 1.88976617451366 8.95877192959537e-06 0.000791817611315776 GO:0022853 active monoatomic ion transmembrane transporter activity 31/2202 118/18639 0.26271186440678 2.22374497760126 1.21647740607714e-05 0.000998380385416167 GO:0008168 methyltransferase activity 45/2202 204/18639 0.220588235294118 1.86718624779612 2.31586775731885e-05 0.00177395470210624 GO:0019104 DNA N-glycosylase activity 8/2202 13/18639 0.615384615384615 5.20897086564662 2.7828659206232e-05 0.00199844558924753 GO:0140030 modification-dependent protein binding 39/2202 173/18639 0.225433526011561 1.90819958734309 4.75598410753016e-05 0.00321448572914832 GO:0043021 ribonucleoprotein complex binding 39/2202 177/18639 0.220338983050847 1.86507643282686 8.0761788127021e-05 0.00515529414210817 GO:0004518 nuclease activity 44/2202 209/18639 0.210526315789474 1.78201634877384 9.14737496660468e-05 0.00553175465085725 GO:0019843 rRNA binding 19/2202 65/18639 0.292307692307692 2.47426116118214 0.000124601588670077 0.00708894579089992 GO:0140097 catalytic activity, acting on DNA 63/2202 336/18639 0.1875 1.5871083106267 0.000129562977901565 0.00708894579089992 GO:0106310 protein serine kinase activity 66/2202 361/18639 0.182825484764543 1.54754051340886 0.00019408402764486 0.0101364794438156 GO:0008173 RNA methyltransferase activity 18/2202 67/18639 0.26865671641791 2.27406563910692 0.000582204296052742 0.0290849015723739 GO:0044389 ubiquitin-like protein ligase binding 58/2202 322/18639 0.180124223602484 1.52467547853166 0.00067285612350292 0.031992023607927 GO:1990948 ubiquitin ligase inhibitor activity 6/2202 11/18639 0.545454545454545 4.61704235818677 0.000735012687700612 0.031992023607927 GO:0004519 endonuclease activity 28/2202 127/18639 0.220472440944882 1.86620609753481 0.000761816614380444 0.031992023607927 GO:0008017 microtubule binding 51/2202 276/18639 0.184782608695652 1.56410674090748 0.00076370604703171 0.031992023607927 GO:0031267 small GTPase binding 52/2202 283/18639 0.183745583038869 1.55532875670367 0.000779614152325462 0.031992023607927 GO:0055105 ubiquitin-protein transferase inhibitor activity 7/2202 15/18639 0.466666666666667 3.95013623978202 0.000863498182013069 0.0335890034900701 GO:0003774 cytoskeletal motor activity 32/2202 153/18639 0.209150326797386 1.77036918309558 0.000876997480158489 0.0335890034900701 GO:0034212 protein N-acetyltransferase activity 15/2202 53/18639 0.283018867924528 2.39563518585163 0.000908690361051539 0.0336801685434909 GO:0031625 ubiquitin protein ligase binding 54/2202 302/18639 0.178807947019868 1.51353375318043 0.00120021331010752 0.0429605509170407 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 8/2202 20/18639 0.4 3.3858310626703 0.00126870649699525 0.0429605509170407 GO:0008175 tRNA methyltransferase activity 11/2202 34/18639 0.323529411764706 2.73853983010098 0.00130508251804366 0.0429605509170407 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 12/2202 39/18639 0.307692307692308 2.60448543282331 0.00130863296962265 0.0429605509170407 GO:0003713 transcription coactivator activity 47/2202 256/18639 0.18359375 1.55404355415531 0.00137936791659734 0.0440248260047319 GO:0140297 DNA-binding transcription factor binding 80/2202 488/18639 0.163934426229508 1.38763568142225 0.00144815611958554 0.0449711184163185 GO:0140101 catalytic activity, acting on a tRNA 29/2202 139/18639 0.20863309352518 1.76599102189638 0.00155198706372511 0.0469271877952673 GO:0101005 deubiquitinase activity 25/2202 115/18639 0.217391304347826 1.84012557753821 0.00174857185974249 0.0506042882974517 GO:0015399 primary active transmembrane transporter activity 33/2202 166/18639 0.198795180722892 1.68271724500181 0.00180778942842723 0.0506042882974517 GO:0010314 phosphatidylinositol-5-phosphate binding 8/2202 21/18639 0.380952380952381 3.22460101206695 0.00183896992293118 0.0506042882974517 GO:0015631 tubulin binding 65/2202 385/18639 0.168831168831169 1.42908453943876 0.00186755024097379 0.0506042882974517 GO:0051020 GTPase binding 55/2202 315/18639 0.174603174603175 1.47794213053069 0.00189380713384719 0.0506042882974517 GO:0061733 protein-lysine-acetyltransferase activity 13/2202 47/18639 0.276595744680851 2.34126616035712 0.00245469245362111 0.0641009461184239 GO:0034062 5'-3' RNA polymerase activity 8/2202 22/18639 0.363636363636364 3.07802823879118 0.00259356277723118 0.0647826876312744 GO:0097747 RNA polymerase activity 8/2202 22/18639 0.363636363636364 3.07802823879118 0.00259356277723118 0.0647826876312744 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 7/2202 18/18639 0.388888888888889 3.29178019981835 0.00309971473793459 0.0725549535788771 GO:0008276 protein methyltransferase activity 21/2202 95/18639 0.221052631578947 1.87111716621253 0.00317819078110091 0.0725549535788771 GO:0051287 NAD binding 14/2202 54/18639 0.259259259259259 2.19452013321223 0.00328819542267877 0.0725549535788771 GO:0004843 cysteine-type deubiquitinase activity 23/2202 108/18639 0.212962962962963 1.80264153799576 0.00344229201350377 0.0725549535788771 GO:0016783 sulfurtransferase activity 5/2202 10/18639 0.5 4.23228882833787 0.0034557431718485 0.0725549535788771 GO:0032356 oxidized DNA binding 5/2202 10/18639 0.5 4.23228882833787 0.0034557431718485 0.0725549535788771 GO:0097177 mitochondrial ribosome binding 5/2202 10/18639 0.5 4.23228882833787 0.0034557431718485 0.0725549535788771 GO:0019783 ubiquitin-like protein peptidase activity 26/2202 127/18639 0.204724409448819 1.73290566199661 0.0034598347888989 0.0725549535788771 GO:0042393 histone binding 44/2202 247/18639 0.178137651821862 1.50785998742402 0.00347303955338402 0.0725549535788771 GO:0003697 single-stranded DNA binding 25/2202 121/18639 0.206611570247934 1.74887968113135 0.00360706654583334 0.0740092760921876 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 43/2202 243/18639 0.176954732510288 1.49784707504962 0.00433658464794122 0.0742508113365862 GO:0005346 purine ribonucleotide transmembrane transporter activity 7/2202 19/18639 0.368421052631579 3.11852861035422 0.00441291040263339 0.0742508113365862 GO:0140033 acetylation-dependent protein binding 8/2202 24/18639 0.333333333333333 2.82152588555858 0.00480791021503181 0.0742508113365862 GO:0003777 microtubule motor activity 16/2202 68/18639 0.235294117647059 1.99166533098253 0.00496428928021525 0.0742508113365862 GO:0004676 3-phosphoinositide-dependent protein kinase activity 43/2202 245/18639 0.175510204081633 1.48561975198799 0.00504103968528663 0.0742508113365862 GO:0004711 ribosomal protein S6 kinase activity 43/2202 245/18639 0.175510204081633 1.48561975198799 0.00504103968528663 0.0742508113365862 GO:0035175 histone H3S10 kinase activity 43/2202 245/18639 0.175510204081633 1.48561975198799 0.00504103968528663 0.0742508113365862 GO:0035979 histone H2AXS139 kinase activity 43/2202 245/18639 0.175510204081633 1.48561975198799 0.00504103968528663 0.0742508113365862 GO:0044022 histone H3S28 kinase activity 43/2202 245/18639 0.175510204081633 1.48561975198799 0.00504103968528663 0.0742508113365862 GO:0044023 histone H4S1 kinase activity 43/2202 245/18639 0.175510204081633 1.48561975198799 0.00504103968528663 0.0742508113365862 GO:0044024 histone H2AS1 kinase activity 43/2202 245/18639 0.175510204081633 1.48561975198799 0.00504103968528663 0.0742508113365862 GO:0044025 histone H2BS14 kinase activity 43/2202 245/18639 0.175510204081633 1.48561975198799 0.00504103968528663 0.0742508113365862 GO:0072354 histone H3T3 kinase activity 43/2202 245/18639 0.175510204081633 1.48561975198799 0.00504103968528663 0.0742508113365862 GO:0072371 histone H2AS121 kinase activity 43/2202 245/18639 0.175510204081633 1.48561975198799 0.00504103968528663 0.0742508113365862 GO:0072518 Rho-dependent protein serine/threonine kinase activity 43/2202 245/18639 0.175510204081633 1.48561975198799 0.00504103968528663 0.0742508113365862 GO:0140823 histone H2BS36 kinase activity 43/2202 245/18639 0.175510204081633 1.48561975198799 0.00504103968528663 0.0742508113365862 GO:0140855 histone H3S57 kinase activity 43/2202 245/18639 0.175510204081633 1.48561975198799 0.00504103968528663 0.0742508113365862 GO:0140995 histone H2A kinase activity 43/2202 245/18639 0.175510204081633 1.48561975198799 0.00504103968528663 0.0742508113365862 GO:0140997 histone H4 kinase activity 43/2202 245/18639 0.175510204081633 1.48561975198799 0.00504103968528663 0.0742508113365862 GO:0140998 histone H2B kinase activity 43/2202 245/18639 0.175510204081633 1.48561975198799 0.00504103968528663 0.0742508113365862 GO:1990244 histone H2AT120 kinase activity 43/2202 245/18639 0.175510204081633 1.48561975198799 0.00504103968528663 0.0742508113365862 GO:0030695 GTPase regulator activity 77/2202 489/18639 0.157464212678937 1.33286805636816 0.00510150239265232 0.0742508113365862 GO:0003714 transcription corepressor activity 37/2202 204/18639 0.181372549019608 1.5352420259657 0.00514867557159606 0.0742508113365862 GO:0017081 chloride channel regulator activity 6/2202 15/18639 0.4 3.3858310626703 0.00523778026115359 0.0742508113365862 GO:0060589 nucleoside-triphosphatase regulator activity 77/2202 490/18639 0.157142857142857 1.33014791747762 0.00537034902407014 0.0742508113365862 GO:0004532 RNA exonuclease activity 11/2202 40/18639 0.275 2.32775885558583 0.00541643108406906 0.0742508113365862 GO:0004677 DNA-dependent protein kinase activity 43/2202 246/18639 0.17479674796748 1.47958064730511 0.00542825774784442 0.0742508113365862 GO:0140857 histone H3T45 kinase activity 43/2202 246/18639 0.17479674796748 1.47958064730511 0.00542825774784442 0.0742508113365862 GO:0043022 ribosome binding 23/2202 112/18639 0.205357142857143 1.73826148306734 0.0055131039150024 0.0745241929216207 GO:0008080 N-acetyltransferase activity 16/2202 69/18639 0.231884057971014 1.96280061604075 0.00576986267476318 0.0755274175890054 GO:0035402 histone H3T11 kinase activity 43/2202 247/18639 0.174089068825911 1.47359044225529 0.00584038707314737 0.0755274175890054 GO:0035403 histone H3T6 kinase activity 43/2202 247/18639 0.174089068825911 1.47359044225529 0.00584038707314737 0.0755274175890054 GO:0004674 protein serine/threonine kinase activity 69/2202 433/18639 0.159353348729792 1.34885879517466 0.00585025253735551 0.0755274175890054 GO:0015215 nucleotide transmembrane transporter activity 9/2202 30/18639 0.3 2.53937329700272 0.00621565505002639 0.0792767299254096 GO:0004679 AMP-activated protein kinase activity 43/2202 248/18639 0.173387096774194 1.46764854531071 0.00627866181306551 0.0792767299254096 GO:0016278 lysine N-methyltransferase activity 16/2202 70/18639 0.228571428571429 1.93476060724017 0.00667803545467788 0.0834028558415748 GO:0005484 SNAP receptor activity 10/2202 36/18639 0.277777777777778 2.35127157129882 0.00728344800264341 0.0899858253229815 GO:0005085 guanyl-nucleotide exchange factor activity 40/2202 230/18639 0.173913043478261 1.47210046203056 0.00776286783213824 0.0948886716928387 GO:0004520 DNA endonuclease activity 11/2202 42/18639 0.261904761904762 2.21691319579603 0.00804143430334831 0.0972590317320759 GO:0005078 MAP-kinase scaffold activity 5/2202 12/18639 0.416666666666667 3.52690735694823 0.00886567343968852 0.103945497777573 GO:0005095 GTPase inhibitor activity 5/2202 12/18639 0.416666666666667 3.52690735694823 0.00886567343968852 0.103945497777573 GO:0034452 dynactin binding 5/2202 12/18639 0.416666666666667 3.52690735694823 0.00886567343968852 0.103945497777573 GO:0141003 histone H2AX kinase activity 57/2202 354/18639 0.161016949152542 1.36294047014271 0.0092908924394143 0.107489550442071 GO:0019787 ubiquitin-like protein transferase activity 74/2202 479/18639 0.154488517745303 1.30768005551984 0.00935505225779558 0.107489550442071 GO:0016922 nuclear receptor binding 26/2202 137/18639 0.18978102189781 1.6064161976173 0.00964069901587932 0.109674882863815 GO:0008170 N-methyltransferase activity 20/2202 98/18639 0.204081632653061 1.72746482789301 0.00989096202050741 0.111418778054539 GO:0045296 cadherin binding 54/2202 334/18639 0.161676646706587 1.36852453131883 0.0102709304596463 0.113749914970801 GO:0042054 histone methyltransferase activity 15/2202 67/18639 0.223880597014925 1.89505469925577 0.0102959017902204 0.113749914970801 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 10/2202 38/18639 0.263157894736842 2.2275204359673 0.0108850647096806 0.119063466224522 GO:0140996 histone H3 kinase activity 57/2202 357/18639 0.159663865546218 1.351487188881 0.0109840969711047 0.119063466224522 GO:0061659 ubiquitin-like protein ligase activity 59/2202 372/18639 0.158602150537634 1.34250021974158 0.0112189963887752 0.120473148137409 GO:0008234 cysteine-type peptidase activity 33/2202 187/18639 0.176470588235294 1.4937489982369 0.0118265625028619 0.125821484405447 GO:0035173 histone kinase activity 57/2202 360/18639 0.158333333333333 1.34022479564033 0.0129267427269332 0.133389533402483 GO:0016410 N-acyltransferase activity 19/2202 94/18639 0.202127659574468 1.7109252710302 0.0129668134065811 0.133389533402483 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 5/2202 13/18639 0.384615384615385 3.25560679102913 0.0130236553547972 0.133389533402483 GO:0000217 DNA secondary structure binding 10/2202 39/18639 0.256410256410256 2.17040452735276 0.0131259524904922 0.133389533402483 GO:0046966 nuclear thyroid hormone receptor binding 8/2202 28/18639 0.285714285714286 2.41845075905021 0.0132344706770087 0.133389533402483 GO:0051959 dynein light intermediate chain binding 8/2202 28/18639 0.285714285714286 2.41845075905021 0.0132344706770087 0.133389533402483 GO:0016279 protein-lysine N-methyltransferase activity 15/2202 69/18639 0.217391304347826 1.84012557753821 0.0134812337415286 0.134695109295794 GO:0004540 RNA nuclease activity 23/2202 121/18639 0.190082644628099 1.60896930664084 0.0140304818508953 0.137001676451564 GO:0000295 adenine nucleotide transmembrane transporter activity 7/2202 23/18639 0.304347826086957 2.57617580855349 0.0140697979297515 0.137001676451564 GO:0070577 lysine-acetylated histone binding 7/2202 23/18639 0.304347826086957 2.57617580855349 0.0140697979297515 0.137001676451564 GO:0098641 cadherin binding involved in cell-cell adhesion 6/2202 18/18639 0.333333333333333 2.82152588555858 0.0142349681406468 0.137155703430351 GO:0004386 helicase activity 28/2202 155/18639 0.180645161290323 1.52908499604465 0.014324355449645 0.137155703430351 GO:0008135 translation factor activity, RNA binding 17/2202 83/18639 0.204819277108434 1.73370867666853 0.0159720695446826 0.15166866038711 GO:0003724 RNA helicase activity 16/2202 77/18639 0.207792207792208 1.75887327930925 0.0166997067692551 0.157278385884214 GO:0000175 3'-5'-RNA exonuclease activity 9/2202 35/18639 0.257142857142857 2.17660568314519 0.0178638378851275 0.161822007344259 GO:0048027 mRNA 5'-UTR binding 7/2202 24/18639 0.291666666666667 2.46883514986376 0.0178835164005186 0.161822007344259 GO:0070300 phosphatidic acid binding 7/2202 24/18639 0.291666666666667 2.46883514986376 0.0178835164005186 0.161822007344259 GO:0004527 exonuclease activity 17/2202 84/18639 0.202380952380952 1.71306928766057 0.0178863315341348 0.161822007344259 GO:0180051 translation factor activity 17/2202 84/18639 0.202380952380952 1.71306928766057 0.0178863315341348 0.161822007344259 GO:0005347 ATP transmembrane transporter activity 5/2202 14/18639 0.357142857142857 3.02306344881277 0.018321204202186 0.162137156122786 GO:0030983 mismatched DNA binding 5/2202 14/18639 0.357142857142857 3.02306344881277 0.018321204202186 0.162137156122786 GO:0031593 polyubiquitin modification-dependent protein binding 13/2202 59/18639 0.220338983050847 1.86507643282686 0.018485611359517 0.162137156122786 GO:0070063 RNA polymerase binding 13/2202 59/18639 0.220338983050847 1.86507643282686 0.018485611359517 0.162137156122786 GO:0004842 ubiquitin-protein transferase activity 68/2202 449/18639 0.151447661469933 1.28194049143419 0.0186292328660725 0.162140535085429 GO:0120227 acyl-CoA binding 6/2202 19/18639 0.315789473684211 2.67302452316076 0.0187682255581915 0.162140535085429 GO:0061630 ubiquitin protein ligase activity 55/2202 353/18639 0.155807365439093 1.31884354424126 0.0193306918626521 0.165488409511147 GO:0003924 GTPase activity 52/2202 331/18639 0.157099697885196 1.32978259258954 0.0194438079060095 0.165488409511147 GO:0016755 aminoacyltransferase activity 74/2202 496/18639 0.149193548387097 1.26286037619759 0.0201930757574464 0.170601794450779 GO:0008186 ATP-dependent activity, acting on RNA 16/2202 79/18639 0.20253164556962 1.71434484185838 0.021040517985566 0.174310915283709 GO:0001098 basal transcription machinery binding 13/2202 60/18639 0.216666666666667 1.83399182561308 0.0211233481358178 0.174310915283709 GO:0001099 basal RNA polymerase II transcription machinery binding 13/2202 60/18639 0.216666666666667 1.83399182561308 0.0211233481358178 0.174310915283709 GO:0045505 dynein intermediate chain binding 9/2202 36/18639 0.25 2.11614441416894 0.0213906345126222 0.174310915283709 GO:0055106 ubiquitin-protein transferase regulator activity 9/2202 36/18639 0.25 2.11614441416894 0.0213906345126222 0.174310915283709 GO:0017069 snRNA binding 12/2202 54/18639 0.222222222222222 1.88101725703906 0.0216622308619896 0.175281008876239 GO:0004402 histone acetyltransferase activity 10/2202 42/18639 0.238095238095238 2.01537563254184 0.0219270032025414 0.176182704053987 GO:0043130 ubiquitin binding 19/2202 100/18639 0.19 1.60826975476839 0.0240917782710275 0.191723867187232 GO:0030742 GTP-dependent protein binding 6/2202 20/18639 0.3 2.53937329700272 0.0241949179653164 0.191723867187232 GO:0004129 cytochrome-c oxidase activity 5/2202 15/18639 0.333333333333333 2.82152588555858 0.0248629161727023 0.195667744400239 GO:0008157 protein phosphatase 1 binding 7/2202 26/18639 0.269230769230769 2.27892475372039 0.0275747189575558 0.212639946860615 GO:0015216 purine nucleotide transmembrane transporter activity 7/2202 26/18639 0.269230769230769 2.27892475372039 0.0275747189575558 0.212639946860615 GO:0050681 nuclear androgen receptor binding 7/2202 26/18639 0.269230769230769 2.27892475372039 0.0275747189575558 0.212639946860615 GO:0140034 methylation-dependent protein binding 15/2202 76/18639 0.197368421052632 1.67064032697548 0.030878133380303 0.235293072325031 GO:0019903 protein phosphatase binding 25/2202 144/18639 0.173611111111111 1.46954473206176 0.0309218920113836 0.235293072325031 GO:0016407 acetyltransferase activity 18/2202 96/18639 0.1875 1.5871083106267 0.0311274847362248 0.235299210275805 GO:0005525 GTP binding 57/2202 378/18639 0.150793650793651 1.2764045672765 0.0313631370138139 0.235531009339034 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 4/2202 11/18639 0.363636363636364 3.07802823879118 0.0323569470619906 0.236528618324289 GO:0015217 ADP transmembrane transporter activity 4/2202 11/18639 0.363636363636364 3.07802823879118 0.0323569470619906 0.236528618324289 GO:0034511 U3 snoRNA binding 4/2202 11/18639 0.363636363636364 3.07802823879118 0.0323569470619906 0.236528618324289 GO:0070990 snRNP binding 4/2202 11/18639 0.363636363636364 3.07802823879118 0.0323569470619906 0.236528618324289 GO:0016675 oxidoreductase activity, acting on a heme group of donors 5/2202 16/18639 0.3125 2.64518051771117 0.0327311142850844 0.236528618324289 GO:0017070 U6 snRNA binding 5/2202 16/18639 0.3125 2.64518051771117 0.0327311142850844 0.236528618324289 GO:0015252 proton channel activity 7/2202 27/18639 0.259259259259259 2.19452013321223 0.0335442210167708 0.240889437176685 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 8/2202 33/18639 0.242424242424242 2.05201882586079 0.0347798292042703 0.248058732005091 GO:0008094 ATP-dependent activity, acting on DNA 34/2202 210/18639 0.161904761904762 1.37045543012845 0.0349743381939292 0.248058732005091 GO:0003689 DNA clamp loader activity 27/2202 160/18639 0.16875 1.42839747956403 0.0354937843350837 0.250198516570621 GO:0008093 cytoskeletal anchor activity 6/2202 22/18639 0.272727272727273 2.30852117909339 0.0379657176232766 0.264505076562014 GO:0005080 protein kinase C binding 11/2202 52/18639 0.211538461538462 1.79058373506602 0.0379837577308375 0.264505076562014 GO:0160215 deacylase activity 13/2202 65/18639 0.2 1.69291553133515 0.0386627396406617 0.267611372573014 GO:0036408 histone H3K14 acetyltransferase activity 7/2202 28/18639 0.25 2.11614441416894 0.0403141377966914 0.272542831275297 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 7/2202 28/18639 0.25 2.11614441416894 0.0403141377966914 0.272542831275297 GO:0032182 ubiquitin-like protein binding 21/2202 120/18639 0.175 1.48130108991826 0.0417865419583019 0.272542831275297 GO:0016835 carbon-oxygen lyase activity 15/2202 79/18639 0.189873417721519 1.60719828924223 0.0419834846500432 0.272542831275297 GO:0004549 tRNA-specific ribonuclease activity 5/2202 17/18639 0.294117647058824 2.48958166372816 0.0419844048178656 0.272542831275297 GO:0004550 nucleoside diphosphate kinase activity 5/2202 17/18639 0.294117647058824 2.48958166372816 0.0419844048178656 0.272542831275297 GO:0004659 prenyltransferase activity 5/2202 17/18639 0.294117647058824 2.48958166372816 0.0419844048178656 0.272542831275297 GO:0008429 phosphatidylethanolamine binding 5/2202 17/18639 0.294117647058824 2.48958166372816 0.0419844048178656 0.272542831275297 GO:0008569 minus-end-directed microtubule motor activity 5/2202 17/18639 0.294117647058824 2.48958166372816 0.0419844048178656 0.272542831275297 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 5/2202 17/18639 0.294117647058824 2.48958166372816 0.0419844048178656 0.272542831275297 GO:0070403 NAD+ binding 5/2202 17/18639 0.294117647058824 2.48958166372816 0.0419844048178656 0.272542831275297 GO:0004857 enzyme inhibitor activity 61/2202 416/18639 0.146634615384615 1.24120008907986 0.0435999738109081 0.281440280386143 GO:0097371 MDM2/MDM4 family protein binding 4/2202 12/18639 0.333333333333333 2.82152588555858 0.0441025838731417 0.283094239498547 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 9/2202 41/18639 0.219512195121951 1.85807802219712 0.0466585904814659 0.297837335906691 GO:0010484 histone H3 acetyltransferase activity 7/2202 29/18639 0.241379310344828 2.04317391712863 0.0479141854421626 0.302491203698048 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 7/2202 29/18639 0.241379310344828 2.04317391712863 0.0479141854421626 0.302491203698048 GO:0031491 nucleosome binding 14/2202 74/18639 0.189189189189189 1.60140658369541 0.0495956913233112 0.309703528970025 GO:0035064 methylated histone binding 14/2202 74/18639 0.189189189189189 1.60140658369541 0.0495956913233112 0.309703528970025 GO:0051015 actin filament binding 33/2202 209/18639 0.157894736842105 1.33651226158038 0.050377656648727 0.312886094537229 GO:0032266 phosphatidylinositol-3-phosphate binding 10/2202 48/18639 0.208333333333333 1.76345367847411 0.0510467428790182 0.314163795822521 GO:0016836 hydro-lyase activity 12/2202 61/18639 0.19672131147541 1.6651628177067 0.0511302261260326 0.314163795822521 GO:0140223 general transcription initiation factor activity 13/2202 68/18639 0.191176470588235 1.6182280814233 0.0531400166613831 0.324659791460174 GO:0043175 RNA polymerase core enzyme binding 9/2202 42/18639 0.214285714285714 1.81383806928766 0.0534035688302636 0.324659791460174 GO:0098632 cell-cell adhesion mediator activity 11/2202 55/18639 0.2 1.69291553133515 0.0543761882408529 0.328832843624947 GO:0043995 histone H4K5 acetyltransferase activity 7/2202 30/18639 0.233333333333333 1.97506811989101 0.0563666039196334 0.334396189448615 GO:0043996 histone H4K8 acetyltransferase activity 7/2202 30/18639 0.233333333333333 1.97506811989101 0.0563666039196334 0.334396189448615 GO:0043997 histone H4K12 acetyltransferase activity 7/2202 30/18639 0.233333333333333 1.97506811989101 0.0563666039196334 0.334396189448615 GO:0019001 guanyl nucleotide binding 58/2202 400/18639 0.145 1.22736376021798 0.0573332564558098 0.334396189448615 GO:0032561 guanyl ribonucleotide binding 58/2202 400/18639 0.145 1.22736376021798 0.0573332564558098 0.334396189448615 GO:0004535 poly(A)-specific ribonuclease activity 4/2202 13/18639 0.307692307692308 2.60448543282331 0.0579154409924059 0.334396189448615 GO:0046975 histone H3K36 methyltransferase activity 4/2202 13/18639 0.307692307692308 2.60448543282331 0.0579154409924059 0.334396189448615 GO:0089720 caspase binding 4/2202 13/18639 0.307692307692308 2.60448543282331 0.0579154409924059 0.334396189448615 GO:0097157 pre-mRNA intronic binding 4/2202 13/18639 0.307692307692308 2.60448543282331 0.0579154409924059 0.334396189448615 GO:0004712 protein serine/threonine/tyrosine kinase activity 9/2202 43/18639 0.209302325581395 1.77165578860655 0.0607530689757874 0.349026381265898 GO:0019210 kinase inhibitor activity 16/2202 90/18639 0.177777777777778 1.50481380563124 0.0613507665947328 0.350706620981831 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 51/2202 349/18639 0.146131805157593 1.23694401286666 0.0634571410638373 0.359747784563722 GO:0019213 deacetylase activity 8/2202 37/18639 0.216216216216216 1.83017895279476 0.0635585729037733 0.359747784563722 GO:0015605 organophosphate ester transmembrane transporter activity 10/2202 50/18639 0.2 1.69291553133515 0.0647312244426215 0.362974668325194 GO:1990380 K48-linked deubiquitinase activity 5/2202 19/18639 0.263157894736842 2.2275204359673 0.0647604934783854 0.362974668325194 GO:0004860 protein kinase inhibitor activity 15/2202 84/18639 0.178571428571429 1.51153172440638 0.0663280398474593 0.369096841534318 GO:0042974 nuclear retinoic acid receptor binding 6/2202 25/18639 0.24 2.03149863760218 0.0664952534356866 0.369096841534318 GO:0004536 DNA nuclease activity 12/2202 64/18639 0.1875 1.5871083106267 0.0695940352355002 0.384440127334566 GO:0003743 translation initiation factor activity 10/2202 51/18639 0.196078431372549 1.65972110915211 0.0723764601624661 0.396876962501944 GO:0042162 telomeric DNA binding 8/2202 38/18639 0.210526315789474 1.78201634877384 0.0725362594651073 0.396876962501944 GO:0044548 S100 protein binding 4/2202 14/18639 0.285714285714286 2.41845075905021 0.0737531357084938 0.399728079854054 GO:0061665 SUMO ligase activity 4/2202 14/18639 0.285714285714286 2.41845075905021 0.0737531357084938 0.399728079854054 GO:0008408 3'-5' exonuclease activity 11/2202 58/18639 0.189655172413793 1.60535093488678 0.0749127870097048 0.403632304416471 GO:0031369 translation initiation factor binding 7/2202 32/18639 0.21875 1.85162636239782 0.0758786577493104 0.403632304416471 GO:0043425 bHLH transcription factor binding 7/2202 32/18639 0.21875 1.85162636239782 0.0758786577493104 0.403632304416471 GO:0051059 NF-kappaB binding 7/2202 32/18639 0.21875 1.85162636239782 0.0758786577493104 0.403632304416471 GO:0019888 protein phosphatase regulator activity 18/2202 107/18639 0.168224299065421 1.4239476431791 0.0770072788811468 0.407748218591879 GO:0016505 peptidase activator activity involved in apoptotic process 5/2202 20/18639 0.25 2.11614441416894 0.0782823519827417 0.410714257662878 GO:0043024 ribosomal small subunit binding 5/2202 20/18639 0.25 2.11614441416894 0.0782823519827417 0.410714257662878 GO:0005096 GTPase activator activity 40/2202 271/18639 0.14760147601476 1.2493841559669 0.0809998786002208 0.423040275052971 GO:0016874 ligase activity 26/2202 167/18639 0.155688622754491 1.31783843756628 0.0858909712848224 0.446555321295298 GO:0019902 phosphatase binding 29/2202 190/18639 0.152631578947368 1.29196185286104 0.0889742416424197 0.457259024192155 GO:0016251 RNA polymerase II general transcription initiation factor activity 10/2202 53/18639 0.188679245283019 1.59709012390108 0.0893000200849479 0.457259024192155 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 11/2202 60/18639 0.183333333333333 1.55183923705722 0.0910028825465949 0.457259024192155 GO:0004467 long-chain fatty acid-CoA ligase activity 4/2202 15/18639 0.266666666666667 2.25722070844687 0.0915313973578726 0.457259024192155 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 4/2202 15/18639 0.266666666666667 2.25722070844687 0.0915313973578726 0.457259024192155 GO:0031386 protein tag activity 4/2202 15/18639 0.266666666666667 2.25722070844687 0.0915313973578726 0.457259024192155 GO:0042809 nuclear vitamin D receptor binding 4/2202 15/18639 0.266666666666667 2.25722070844687 0.0915313973578726 0.457259024192155 GO:0050700 CARD domain binding 4/2202 15/18639 0.266666666666667 2.25722070844687 0.0915313973578726 0.457259024192155 GO:0141047 molecular tag activity 4/2202 15/18639 0.266666666666667 2.25722070844687 0.0915313973578726 0.457259024192155 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 8/2202 40/18639 0.2 1.69291553133515 0.092677917492171 0.457958372973005 GO:0035613 RNA stem-loop binding 5/2202 21/18639 0.238095238095238 2.01537563254184 0.093190239111383 0.457958372973005 GO:0051010 microtubule plus-end binding 5/2202 21/18639 0.238095238095238 2.01537563254184 0.093190239111383 0.457958372973005 GO:0019208 phosphatase regulator activity 19/2202 117/18639 0.162393162393162 1.37458953399008 0.093265673869176 0.457958372973005 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 21/2202 132/18639 0.159090909090909 1.34663735447114 0.09564239781435 0.467630276973141 GO:0140938 histone H3 methyltransferase activity 9/2202 47/18639 0.191489361702128 1.62087657255493 0.096350713940118 0.469097331852524 GO:0030332 cyclin binding 7/2202 34/18639 0.205882352941176 1.74270716460971 0.0988722408414116 0.479108834391331 GO:0000287 magnesium ion binding 34/2202 230/18639 0.147826086956522 1.25128539272598 0.0992409944170032 0.479108834391331 GO:1901981 phosphatidylinositol phosphate binding 28/2202 185/18639 0.151351351351351 1.28112526695633 0.100922322197996 0.485187230985343 GO:0001094 TFIID-class transcription factor complex binding 3/2202 10/18639 0.3 2.53937329700272 0.104719664832257 0.485475770272954 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 3/2202 10/18639 0.3 2.53937329700272 0.104719664832257 0.485475770272954 GO:0016303 1-phosphatidylinositol-3-kinase activity 3/2202 10/18639 0.3 2.53937329700272 0.104719664832257 0.485475770272954 GO:0016427 tRNA (cytidine) methyltransferase activity 3/2202 10/18639 0.3 2.53937329700272 0.104719664832257 0.485475770272954 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 3/2202 10/18639 0.3 2.53937329700272 0.104719664832257 0.485475770272954 GO:0047429 nucleoside triphosphate diphosphatase activity 3/2202 10/18639 0.3 2.53937329700272 0.104719664832257 0.485475770272954 GO:0016887 ATP hydrolysis activity 58/2202 417/18639 0.139088729016787 1.17732734793092 0.104924211483683 0.485475770272954 GO:0032931 histone H3K56 acetyltransferase activity 5/2202 22/18639 0.227272727272727 1.92376764924449 0.109432745431414 0.485475770272954 GO:0043992 histone H3K9 acetyltransferase activity 5/2202 22/18639 0.227272727272727 1.92376764924449 0.109432745431414 0.485475770272954 GO:0043993 histone H3K18 acetyltransferase activity 5/2202 22/18639 0.227272727272727 1.92376764924449 0.109432745431414 0.485475770272954 GO:0043994 histone H3K23 acetyltransferase activity 5/2202 22/18639 0.227272727272727 1.92376764924449 0.109432745431414 0.485475770272954 GO:0043999 histone H2AK5 acetyltransferase activity 5/2202 22/18639 0.227272727272727 1.92376764924449 0.109432745431414 0.485475770272954 GO:0044012 histone H2AK9 acetyltransferase activity 5/2202 22/18639 0.227272727272727 1.92376764924449 0.109432745431414 0.485475770272954 GO:0044014 histone H2BK5 acetyltransferase activity 5/2202 22/18639 0.227272727272727 1.92376764924449 0.109432745431414 0.485475770272954 GO:0044015 histone H2BK12 acetyltransferase activity 5/2202 22/18639 0.227272727272727 1.92376764924449 0.109432745431414 0.485475770272954 GO:0044016 histone H3K4 acetyltransferase activity 5/2202 22/18639 0.227272727272727 1.92376764924449 0.109432745431414 0.485475770272954 GO:0044017 histone H3K27 acetyltransferase activity 5/2202 22/18639 0.227272727272727 1.92376764924449 0.109432745431414 0.485475770272954 GO:0044018 histone H3K36 acetyltransferase activity 5/2202 22/18639 0.227272727272727 1.92376764924449 0.109432745431414 0.485475770272954 GO:0046972 histone H4K16 acetyltransferase activity 5/2202 22/18639 0.227272727272727 1.92376764924449 0.109432745431414 0.485475770272954 GO:0140908 histone H3K122 acetyltransferase activity 5/2202 22/18639 0.227272727272727 1.92376764924449 0.109432745431414 0.485475770272954 GO:0000062 fatty-acyl-CoA binding 4/2202 16/18639 0.25 2.11614441416894 0.111131491715469 0.485513627304463 GO:0005324 long-chain fatty acid transmembrane transporter activity 4/2202 16/18639 0.25 2.11614441416894 0.111131491715469 0.485513627304463 GO:0005521 lamin binding 4/2202 16/18639 0.25 2.11614441416894 0.111131491715469 0.485513627304463 GO:0030275 LRR domain binding 4/2202 16/18639 0.25 2.11614441416894 0.111131491715469 0.485513627304463 GO:0010485 histone H4 acetyltransferase activity 7/2202 35/18639 0.2 1.69291553133515 0.111647982822744 0.485922470694444 GO:0003779 actin binding 61/2202 443/18639 0.137697516930023 1.1655513251856 0.113377060962773 0.491585822815946 GO:0051879 Hsp90 protein binding 8/2202 42/18639 0.19047619047619 1.61230050603348 0.115700129544168 0.499772364083641 GO:0140658 ATP-dependent chromatin remodeler activity 24/2202 158/18639 0.151898734177215 1.28575863139378 0.117788547906083 0.505351187260519 GO:0016763 pentosyltransferase activity 9/2202 49/18639 0.183673469387755 1.55471834510371 0.117871295200887 0.505351187260519 GO:0019212 phosphatase inhibitor activity 10/2202 56/18639 0.178571428571429 1.51153172440638 0.118763620979625 0.506849755177365 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 6/2202 29/18639 0.206896551724138 1.7512919289674 0.119544198131476 0.506849755177365 GO:0097472 cyclin-dependent protein kinase activity 6/2202 29/18639 0.206896551724138 1.7512919289674 0.119544198131476 0.506849755177365 GO:0035591 signaling adaptor activity 20/2202 129/18639 0.155038759689922 1.31233762119004 0.123642962484647 0.52230060255463 GO:0000993 RNA polymerase II complex binding 7/2202 36/18639 0.194444444444444 1.64589009990917 0.125247765324114 0.527141693616876 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 19/2202 122/18639 0.155737704918033 1.31825389735114 0.126729998561017 0.528464900258817 GO:0008171 O-methyltransferase activity 5/2202 23/18639 0.217391304347826 1.84012557753821 0.126941960375486 0.528464900258817 GO:0044013 histone H2B acetyltransferase activity 5/2202 23/18639 0.217391304347826 1.84012557753821 0.126941960375486 0.528464900258817 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 8/2202 43/18639 0.186046511627907 1.57480514542805 0.128259457674083 0.531944890568946 GO:0051219 phosphoprotein binding 15/2202 93/18639 0.161290322580645 1.36525446075415 0.130499879137631 0.531944890568946 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 3/2202 11/18639 0.272727272727273 2.30852117909339 0.131855683996107 0.531944890568946 GO:0008432 JUN kinase binding 3/2202 11/18639 0.272727272727273 2.30852117909339 0.131855683996107 0.531944890568946 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 3/2202 11/18639 0.272727272727273 2.30852117909339 0.131855683996107 0.531944890568946 GO:0032404 mismatch repair complex binding 3/2202 11/18639 0.272727272727273 2.30852117909339 0.131855683996107 0.531944890568946 GO:0043522 leucine zipper domain binding 3/2202 11/18639 0.272727272727273 2.30852117909339 0.131855683996107 0.531944890568946 GO:0140537 transcription regulator activator activity 3/2202 11/18639 0.272727272727273 2.30852117909339 0.131855683996107 0.531944890568946 GO:0046965 nuclear retinoid X receptor binding 4/2202 17/18639 0.235294117647059 1.99166533098253 0.132407518453193 0.531944890568946 GO:1901567 fatty acid derivative binding 4/2202 17/18639 0.235294117647059 1.99166533098253 0.132407518453193 0.531944890568946 GO:0051721 protein phosphatase 2A binding 6/2202 30/18639 0.2 1.69291553133515 0.135338596684437 0.540692688233382 GO:0046332 SMAD binding 13/2202 79/18639 0.164556962025316 1.39290518400993 0.135526104622467 0.540692688233382 GO:0035091 phosphatidylinositol binding 40/2202 284/18639 0.140845070422535 1.19219403615151 0.136041285248878 0.540870023359725 GO:0016790 thiolester hydrolase activity 8/2202 44/18639 0.181818181818182 1.53901411939559 0.141490974457017 0.560596998796939 GO:0001217 DNA-binding transcription repressor activity 39/2202 278/18639 0.140287769784173 1.18747672161998 0.1451781344782 0.567239556559231 GO:0000049 tRNA binding 13/2202 80/18639 0.1625 1.37549386920981 0.145345910641376 0.567239556559231 GO:0001091 RNA polymerase II general transcription initiation factor binding 5/2202 24/18639 0.208333333333333 1.76345367847411 0.145635917480394 0.567239556559231 GO:0043998 histone H2A acetyltransferase activity 5/2202 24/18639 0.208333333333333 1.76345367847411 0.145635917480394 0.567239556559231 GO:0050699 WW domain binding 5/2202 24/18639 0.208333333333333 1.76345367847411 0.145635917480394 0.567239556559231 GO:0004521 RNA endonuclease activity 12/2202 73/18639 0.164383561643836 1.39143742301519 0.148174020867692 0.57517550667898 GO:0005164 tumor necrosis factor receptor binding 6/2202 31/18639 0.193548387096774 1.63830535290498 0.152055247559803 0.586280132369844 GO:0070273 phosphatidylinositol-4-phosphate binding 6/2202 31/18639 0.193548387096774 1.63830535290498 0.152055247559803 0.586280132369844 GO:0045309 protein phosphorylated amino acid binding 10/2202 59/18639 0.169491525423729 1.43467417909758 0.152961025186603 0.586569432882731 GO:0000146 microfilament motor activity 7/2202 38/18639 0.184210526315789 1.55926430517711 0.154794799102826 0.586569432882731 GO:0000400 four-way junction DNA binding 4/2202 18/18639 0.222222222222222 1.88101725703906 0.155193305131724 0.586569432882731 GO:0003746 translation elongation factor activity 4/2202 18/18639 0.222222222222222 1.88101725703906 0.155193305131724 0.586569432882731 GO:0004706 JUN kinase kinase kinase activity 4/2202 18/18639 0.222222222222222 1.88101725703906 0.155193305131724 0.586569432882731 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 4/2202 18/18639 0.222222222222222 1.88101725703906 0.155193305131724 0.586569432882731 GO:0004300 enoyl-CoA hydratase activity 3/2202 12/18639 0.25 2.11614441416894 0.161106717370429 0.592532004260722 GO:0004526 ribonuclease P activity 3/2202 12/18639 0.25 2.11614441416894 0.161106717370429 0.592532004260722 GO:0004859 phospholipase inhibitor activity 3/2202 12/18639 0.25 2.11614441416894 0.161106717370429 0.592532004260722 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 3/2202 12/18639 0.25 2.11614441416894 0.161106717370429 0.592532004260722 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 3/2202 12/18639 0.25 2.11614441416894 0.161106717370429 0.592532004260722 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 3/2202 12/18639 0.25 2.11614441416894 0.161106717370429 0.592532004260722 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 3/2202 12/18639 0.25 2.11614441416894 0.161106717370429 0.592532004260722 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 3/2202 12/18639 0.25 2.11614441416894 0.161106717370429 0.592532004260722 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 14/2202 89/18639 0.157303370786517 1.33150659767933 0.161927806212242 0.592532004260722 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 14/2202 89/18639 0.157303370786517 1.33150659767933 0.161927806212242 0.592532004260722 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 10/2202 60/18639 0.166666666666667 1.41076294277929 0.165352653714605 0.59582703740381 GO:0004709 MAP kinase kinase kinase activity 5/2202 25/18639 0.2 1.69291553133515 0.165421083491571 0.59582703740381 GO:0017025 TBP-class protein binding 5/2202 25/18639 0.2 1.69291553133515 0.165421083491571 0.59582703740381 GO:0047617 fatty acyl-CoA hydrolase activity 5/2202 25/18639 0.2 1.69291553133515 0.165421083491571 0.59582703740381 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 5/2202 25/18639 0.2 1.69291553133515 0.165421083491571 0.59582703740381 GO:0004864 protein phosphatase inhibitor activity 9/2202 53/18639 0.169811320754717 1.43738111151098 0.167954509118774 0.601182962546639 GO:0140296 general transcription initiation factor binding 9/2202 53/18639 0.169811320754717 1.43738111151098 0.167954509118774 0.601182962546639 GO:0030515 snoRNA binding 6/2202 32/18639 0.1875 1.5871083106267 0.169634460592993 0.603368100949271 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 8/2202 46/18639 0.173913043478261 1.47210046203056 0.169864774237173 0.603368100949271 GO:0019003 GDP binding 12/2202 75/18639 0.16 1.35433242506812 0.17023059040907 0.603368100949271 GO:0016776 phosphotransferase activity, phosphate group as acceptor 7/2202 39/18639 0.179487179487179 1.51928316914693 0.170665476769811 0.603368100949271 GO:0140793 histone H2AXY142 phosphatase activity 14/2202 90/18639 0.155555555555556 1.31671207992734 0.172207375250411 0.606951761235343 GO:0000510 H3-H4 histone complex chaperone activity 22/2202 151/18639 0.145695364238411 1.23324972481369 0.175594395006408 0.611387757158676 GO:0140584 chromatin extrusion motor activity 22/2202 151/18639 0.145695364238411 1.23324972481369 0.175594395006408 0.611387757158676 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 22/2202 151/18639 0.145695364238411 1.23324972481369 0.175594395006408 0.611387757158676 GO:0140849 ATP-dependent H2AZ histone chaperone activity 22/2202 151/18639 0.145695364238411 1.23324972481369 0.175594395006408 0.611387757158676 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 37/2202 268/18639 0.138059701492537 1.16861706454105 0.17710852209038 0.614796652211018 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 10/2202 61/18639 0.163934426229508 1.38763568142225 0.178211043274504 0.616576181220257 GO:0008574 plus-end-directed microtubule motor activity 4/2202 19/18639 0.210526315789474 1.78201634877384 0.179308721572614 0.616576181220257 GO:0015245 fatty acid transmembrane transporter activity 4/2202 19/18639 0.210526315789474 1.78201634877384 0.179308721572614 0.616576181220257 GO:0017022 myosin binding 12/2202 76/18639 0.157894736842105 1.33651226158038 0.181831530733614 0.616576181220257 GO:0098631 cell adhesion mediator activity 12/2202 76/18639 0.157894736842105 1.33651226158038 0.181831530733614 0.616576181220257 GO:0015616 DNA translocase activity 22/2202 152/18639 0.144736842105263 1.22513623978202 0.183756320131645 0.616576181220257 GO:0140674 ATP-dependent histone chaperone activity 22/2202 152/18639 0.144736842105263 1.22513623978202 0.183756320131645 0.616576181220257 GO:0001784 phosphotyrosine residue binding 8/2202 47/18639 0.170212765957447 1.44077917560438 0.184944581477595 0.616576181220257 GO:0008198 ferrous iron binding 5/2202 26/18639 0.192307692307692 1.62780339551457 0.186194814375487 0.616576181220257 GO:0016289 acyl-CoA hydrolase activity 5/2202 26/18639 0.192307692307692 1.62780339551457 0.186194814375487 0.616576181220257 GO:0030247 polysaccharide binding 5/2202 26/18639 0.192307692307692 1.62780339551457 0.186194814375487 0.616576181220257 GO:0034237 protein kinase A regulatory subunit binding 5/2202 26/18639 0.192307692307692 1.62780339551457 0.186194814375487 0.616576181220257 GO:0052742 phosphatidylinositol kinase activity 5/2202 26/18639 0.192307692307692 1.62780339551457 0.186194814375487 0.616576181220257 GO:0070412 R-SMAD binding 5/2202 26/18639 0.192307692307692 1.62780339551457 0.186194814375487 0.616576181220257 GO:0002039 p53 binding 11/2202 69/18639 0.159420289855072 1.34942542352802 0.186694259037802 0.616576181220257 GO:0061791 GTPase motor activity 7/2202 40/18639 0.175 1.48130108991826 0.187208292374159 0.616576181220257 GO:1990606 membrane scission GTPase motor activity 7/2202 40/18639 0.175 1.48130108991826 0.187208292374159 0.616576181220257 GO:0051117 ATPase binding 13/2202 84/18639 0.154761904761905 1.3099941611522 0.18823055244276 0.616576181220257 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 3/2202 13/18639 0.230769230769231 1.95336407461748 0.192064100283836 0.616576181220257 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 3/2202 13/18639 0.230769230769231 1.95336407461748 0.192064100283836 0.616576181220257 GO:0009982 pseudouridine synthase activity 3/2202 13/18639 0.230769230769231 1.95336407461748 0.192064100283836 0.616576181220257 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 3/2202 13/18639 0.230769230769231 1.95336407461748 0.192064100283836 0.616576181220257 GO:0045159 myosin II binding 3/2202 13/18639 0.230769230769231 1.95336407461748 0.192064100283836 0.616576181220257 GO:0046974 histone H3K9 methyltransferase activity 3/2202 13/18639 0.230769230769231 1.95336407461748 0.192064100283836 0.616576181220257 GO:0051011 microtubule minus-end binding 3/2202 13/18639 0.230769230769231 1.95336407461748 0.192064100283836 0.616576181220257 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 3/2202 13/18639 0.230769230769231 1.95336407461748 0.192064100283836 0.616576181220257 GO:0061775 cohesin loader activity 22/2202 153/18639 0.143790849673203 1.21712881337821 0.192109898065145 0.616576181220257 GO:0016829 lyase activity 28/2202 200/18639 0.14 1.1850408719346 0.194664348700164 0.62303436394565 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 8/2202 48/18639 0.166666666666667 1.41076294277929 0.200572402474578 0.640160251231361 GO:0001727 lipid kinase activity 7/2202 41/18639 0.170731707317073 1.4451717950422 0.204373563573036 0.649297087711669 GO:0140939 histone H4 methyltransferase activity 4/2202 20/18639 0.2 1.69291553133515 0.204565313970082 0.649297087711669 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 6/2202 34/18639 0.176470588235294 1.4937489982369 0.207111165961036 0.655566748455179 GO:0004713 protein tyrosine kinase activity 20/2202 140/18639 0.142857142857143 1.20922537952511 0.214323187083027 0.676531159226367 GO:0060590 ATPase regulator activity 8/2202 49/18639 0.163265306122449 1.38197186231441 0.216709203893834 0.681894193934248 GO:0140713 histone chaperone activity 23/2202 164/18639 0.140243902439024 1.18710540307038 0.219898655591358 0.681894193934248 GO:0008307 structural constituent of muscle 7/2202 42/18639 0.166666666666667 1.41076294277929 0.22210825037881 0.681894193934248 GO:0019894 kinesin binding 7/2202 42/18639 0.166666666666667 1.41076294277929 0.22210825037881 0.681894193934248 GO:0140597 protein carrier chaperone 26/2202 188/18639 0.138297872340426 1.17063308017856 0.223675175840013 0.681894193934248 GO:0008174 mRNA methyltransferase activity 3/2202 14/18639 0.214285714285714 1.81383806928766 0.224330726986202 0.681894193934248 GO:0008191 metalloendopeptidase inhibitor activity 3/2202 14/18639 0.214285714285714 1.81383806928766 0.224330726986202 0.681894193934248 GO:0008195 phosphatidate phosphatase activity 3/2202 14/18639 0.214285714285714 1.81383806928766 0.224330726986202 0.681894193934248 GO:0008494 translation activator activity 3/2202 14/18639 0.214285714285714 1.81383806928766 0.224330726986202 0.681894193934248 GO:0031404 chloride ion binding 3/2202 14/18639 0.214285714285714 1.81383806928766 0.224330726986202 0.681894193934248 GO:0032454 histone H3K9 demethylase activity 3/2202 14/18639 0.214285714285714 1.81383806928766 0.224330726986202 0.681894193934248 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 3/2202 14/18639 0.214285714285714 1.81383806928766 0.224330726986202 0.681894193934248 GO:0070742 C2H2 zinc finger domain binding 3/2202 14/18639 0.214285714285714 1.81383806928766 0.224330726986202 0.681894193934248 GO:0071933 Arp2/3 complex binding 3/2202 14/18639 0.214285714285714 1.81383806928766 0.224330726986202 0.681894193934248 GO:0015932 nucleobase-containing compound transmembrane transporter activity 9/2202 57/18639 0.157894736842105 1.33651226158038 0.226279559225643 0.686003201979588 GO:0016866 intramolecular transferase activity 5/2202 28/18639 0.178571428571429 1.51153172440638 0.230265874550642 0.690510741701622 GO:0019789 SUMO transferase activity 5/2202 28/18639 0.178571428571429 1.51153172440638 0.230265874550642 0.690510741701622 GO:0051019 mitogen-activated protein kinase binding 5/2202 28/18639 0.178571428571429 1.51153172440638 0.230265874550642 0.690510741701622 GO:0097718 disordered domain specific binding 5/2202 28/18639 0.178571428571429 1.51153172440638 0.230265874550642 0.690510741701622 GO:0009931 calcium-dependent protein serine/threonine kinase activity 4/2202 21/18639 0.19047619047619 1.61230050603348 0.230771213936835 0.690510741701622 GO:0004197 cysteine-type endopeptidase activity 13/2202 88/18639 0.147727272727273 1.25044897200892 0.236314737959894 0.705261386794593 GO:0008200 ion channel inhibitor activity 7/2202 43/18639 0.162790697674419 1.37795450224954 0.240356626738062 0.715465710160707 GO:0030971 receptor tyrosine kinase binding 12/2202 81/18639 0.148148148148148 1.2540115046927 0.244947228880756 0.727246423731235 GO:0016830 carbon-carbon lyase activity 8/2202 51/18639 0.156862745098039 1.32777688732169 0.250342217616217 0.740450296746784 GO:0016779 nucleotidyltransferase activity 19/2202 136/18639 0.139705882352941 1.18255129027088 0.252024744342618 0.740450296746784 GO:0004181 metallocarboxypeptidase activity 5/2202 29/18639 0.172413793103448 1.45940994080616 0.253332890471302 0.740450296746784 GO:0000774 adenyl-nucleotide exchange factor activity 3/2202 15/18639 0.2 1.69291553133515 0.257530559393284 0.740450296746784 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 3/2202 15/18639 0.2 1.69291553133515 0.257530559393284 0.740450296746784 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 3/2202 15/18639 0.2 1.69291553133515 0.257530559393284 0.740450296746784 GO:0016846 carbon-sulfur lyase activity 3/2202 15/18639 0.2 1.69291553133515 0.257530559393284 0.740450296746784 GO:0045504 dynein heavy chain binding 3/2202 15/18639 0.2 1.69291553133515 0.257530559393284 0.740450296746784 GO:0061578 K63-linked deubiquitinase activity 3/2202 15/18639 0.2 1.69291553133515 0.257530559393284 0.740450296746784 GO:0004407 histone deacetylase activity 4/2202 22/18639 0.181818181818182 1.53901411939559 0.25773531804915 0.740450296746784 GO:0008649 rRNA methyltransferase activity 4/2202 22/18639 0.181818181818182 1.53901411939559 0.25773531804915 0.740450296746784 GO:0033558 protein lysine deacetylase activity 4/2202 22/18639 0.181818181818182 1.53901411939559 0.25773531804915 0.740450296746784 GO:0001046 core promoter sequence-specific DNA binding 7/2202 44/18639 0.159090909090909 1.34663735447114 0.259060939331773 0.740450296746784 GO:0001223 transcription coactivator binding 7/2202 44/18639 0.159090909090909 1.34663735447114 0.259060939331773 0.740450296746784 GO:0016248 channel inhibitor activity 7/2202 44/18639 0.159090909090909 1.34663735447114 0.259060939331773 0.740450296746784 GO:0004725 protein tyrosine phosphatase activity 14/2202 98/18639 0.142857142857143 1.20922537952511 0.26490657805348 0.755279548842303 GO:0000149 SNARE binding 15/2202 106/18639 0.141509433962264 1.19781759292581 0.267278754822751 0.760156656661734 GO:0016798 hydrolase activity, acting on glycosyl bonds 18/2202 130/18639 0.138461538461538 1.17201844477049 0.272094612427584 0.771942493035293 GO:0016769 transferase activity, transferring nitrogenous groups 5/2202 30/18639 0.166666666666667 1.41076294277929 0.276931749228675 0.781804864530091 GO:0035925 mRNA 3'-UTR AU-rich region binding 5/2202 30/18639 0.166666666666667 1.41076294277929 0.276931749228675 0.781804864530091 GO:0141110 transporter inhibitor activity 7/2202 45/18639 0.155555555555556 1.31671207992734 0.278162044563262 0.783353404909774 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 4/2202 23/18639 0.173913043478261 1.47210046203056 0.285270761769922 0.79234292037691 GO:0017134 fibroblast growth factor binding 4/2202 23/18639 0.173913043478261 1.47210046203056 0.285270761769922 0.79234292037691 GO:0140102 catalytic activity, acting on a rRNA 4/2202 23/18639 0.173913043478261 1.47210046203056 0.285270761769922 0.79234292037691 GO:0005544 calcium-dependent phospholipid binding 8/2202 53/18639 0.150943396226415 1.27767209912087 0.285491704992203 0.79234292037691 GO:0051018 protein kinase A binding 8/2202 53/18639 0.150943396226415 1.27767209912087 0.285491704992203 0.79234292037691 GO:1901505 carbohydrate derivative transmembrane transporter activity 8/2202 53/18639 0.150943396226415 1.27767209912087 0.285491704992203 0.79234292037691 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 3/2202 16/18639 0.1875 1.5871083106267 0.291314959626626 0.800767676102854 GO:0005149 interleukin-1 receptor binding 3/2202 16/18639 0.1875 1.5871083106267 0.291314959626626 0.800767676102854 GO:0034450 ubiquitin-ubiquitin ligase activity 3/2202 16/18639 0.1875 1.5871083106267 0.291314959626626 0.800767676102854 GO:0055102 lipase inhibitor activity 3/2202 16/18639 0.1875 1.5871083106267 0.291314959626626 0.800767676102854 GO:0004180 carboxypeptidase activity 7/2202 46/18639 0.152173913043478 1.28808790427674 0.297600016160252 0.816091691093387 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 30/2202 229/18639 0.131004366812227 1.10889663624573 0.30054579284217 0.819401620355916 GO:0005452 solute:inorganic anion antiporter activity 5/2202 31/18639 0.161290322580645 1.36525446075415 0.300946461088074 0.819401620355916 GO:0008327 methyl-CpG binding 5/2202 31/18639 0.161290322580645 1.36525446075415 0.300946461088074 0.819401620355916 GO:0019207 kinase regulator activity 37/2202 287/18639 0.128919860627178 1.09125217176656 0.310128452249645 0.835523011873362 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 61/2202 484/18639 0.12603305785124 1.06681660549013 0.313104567074803 0.835523011873362 GO:0005315 phosphate transmembrane transporter activity 4/2202 24/18639 0.166666666666667 1.41076294277929 0.313197730627827 0.835523011873362 GO:0042625 ATPase-coupled ion transmembrane transporter activity 4/2202 24/18639 0.166666666666667 1.41076294277929 0.313197730627827 0.835523011873362 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 4/2202 24/18639 0.166666666666667 1.41076294277929 0.313197730627827 0.835523011873362 GO:0046961 proton-transporting ATPase activity, rotational mechanism 4/2202 24/18639 0.166666666666667 1.41076294277929 0.313197730627827 0.835523011873362 GO:0070840 dynein complex binding 4/2202 24/18639 0.166666666666667 1.41076294277929 0.313197730627827 0.835523011873362 GO:0140612 DNA damage sensor activity 4/2202 24/18639 0.166666666666667 1.41076294277929 0.313197730627827 0.835523011873362 GO:0005504 fatty acid binding 7/2202 47/18639 0.148936170212766 1.26068177865383 0.317314717229717 0.835523011873362 GO:0051087 protein-folding chaperone binding 18/2202 134/18639 0.134328358208955 1.13703281955346 0.317361149742592 0.835523011873362 GO:0004029 aldehyde dehydrogenase (NAD+) activity 3/2202 17/18639 0.176470588235294 1.4937489982369 0.32536655416379 0.835523011873362 GO:0016805 dipeptidase activity 3/2202 17/18639 0.176470588235294 1.4937489982369 0.32536655416379 0.835523011873362 GO:0017110 nucleoside diphosphate phosphatase activity 3/2202 17/18639 0.176470588235294 1.4937489982369 0.32536655416379 0.835523011873362 GO:0031489 myosin V binding 3/2202 17/18639 0.176470588235294 1.4937489982369 0.32536655416379 0.835523011873362 GO:0032183 SUMO binding 3/2202 17/18639 0.176470588235294 1.4937489982369 0.32536655416379 0.835523011873362 GO:0036041 long-chain fatty acid binding 3/2202 17/18639 0.176470588235294 1.4937489982369 0.32536655416379 0.835523011873362 GO:1902936 phosphatidylinositol bisphosphate binding 15/2202 111/18639 0.135135135135135 1.14386184549672 0.330116633857833 0.835523011873362 GO:0004722 protein serine/threonine phosphatase activity 14/2202 103/18639 0.135922330097087 1.15052511838311 0.330144219862933 0.835523011873362 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 6/2202 40/18639 0.15 1.26968664850136 0.33258938482767 0.835523011873362 GO:0140104 molecular carrier activity 32/2202 249/18639 0.1285140562249 1.08781720889006 0.332882587024888 0.835523011873362 GO:0000182 rDNA binding 2/2202 10/18639 0.2 1.69291553133515 0.33450007437924 0.835523011873362 GO:0004090 carbonyl reductase (NADPH) activity 2/2202 10/18639 0.2 1.69291553133515 0.33450007437924 0.835523011873362 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 2/2202 10/18639 0.2 1.69291553133515 0.33450007437924 0.835523011873362 GO:0004955 prostaglandin receptor activity 2/2202 10/18639 0.2 1.69291553133515 0.33450007437924 0.835523011873362 GO:0005381 iron ion transmembrane transporter activity 2/2202 10/18639 0.2 1.69291553133515 0.33450007437924 0.835523011873362 GO:0008190 eukaryotic initiation factor 4E binding 2/2202 10/18639 0.2 1.69291553133515 0.33450007437924 0.835523011873362 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 2/2202 10/18639 0.2 1.69291553133515 0.33450007437924 0.835523011873362 GO:0016889 DNA endonuclease activity, producing 3'-phosphomonoesters 2/2202 10/18639 0.2 1.69291553133515 0.33450007437924 0.835523011873362 GO:0019531 oxalate transmembrane transporter activity 2/2202 10/18639 0.2 1.69291553133515 0.33450007437924 0.835523011873362 GO:0031434 mitogen-activated protein kinase kinase binding 2/2202 10/18639 0.2 1.69291553133515 0.33450007437924 0.835523011873362 GO:0031957 very long-chain fatty acid-CoA ligase activity 2/2202 10/18639 0.2 1.69291553133515 0.33450007437924 0.835523011873362 GO:0031996 thioesterase binding 2/2202 10/18639 0.2 1.69291553133515 0.33450007437924 0.835523011873362 GO:0033204 ribonuclease P RNA binding 2/2202 10/18639 0.2 1.69291553133515 0.33450007437924 0.835523011873362 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 2/2202 10/18639 0.2 1.69291553133515 0.33450007437924 0.835523011873362 GO:0043295 glutathione binding 2/2202 10/18639 0.2 1.69291553133515 0.33450007437924 0.835523011873362 GO:0050815 phosphoserine residue binding 2/2202 10/18639 0.2 1.69291553133515 0.33450007437924 0.835523011873362 GO:0099122 RNA polymerase II C-terminal domain binding 2/2202 10/18639 0.2 1.69291553133515 0.33450007437924 0.835523011873362 GO:0141109 transporter activator activity 2/2202 10/18639 0.2 1.69291553133515 0.33450007437924 0.835523011873362 GO:0140693 molecular condensate scaffold activity 7/2202 48/18639 0.145833333333333 1.23441757493188 0.337246331944009 0.840555391331163 GO:0015645 fatty acid ligase activity 4/2202 25/18639 0.16 1.35433242506812 0.341345663415686 0.845271912208239 GO:0017056 structural constituent of nuclear pore 4/2202 25/18639 0.16 1.35433242506812 0.341345663415686 0.845271912208239 GO:0120515 fatty acid-CoA ligase activity 4/2202 25/18639 0.16 1.35433242506812 0.341345663415686 0.845271912208239 GO:0005543 phospholipid binding 62/2202 497/18639 0.124748490945674 1.05594328916277 0.342176159441191 0.845506252038555 GO:0140416 transcription regulator inhibitor activity 5/2202 33/18639 0.151515151515152 1.28251176616299 0.349773019474215 0.850414683281493 GO:0017080 sodium channel regulator activity 6/2202 41/18639 0.146341463414634 1.23871868146474 0.354569239899893 0.850414683281493 GO:0042169 SH2 domain binding 6/2202 41/18639 0.146341463414634 1.23871868146474 0.354569239899893 0.850414683281493 GO:0061650 ubiquitin-like protein conjugating enzyme activity 6/2202 41/18639 0.146341463414634 1.23871868146474 0.354569239899893 0.850414683281493 GO:0140318 protein transporter activity 6/2202 41/18639 0.146341463414634 1.23871868146474 0.354569239899893 0.850414683281493 GO:0051082 unfolded protein binding 16/2202 121/18639 0.132231404958678 1.11928299592407 0.355056022550389 0.850414683281493 GO:0001216 DNA-binding transcription activator activity 61/2202 491/18639 0.124236252545825 1.05160740744851 0.356364917554119 0.850414683281493 GO:0016504 peptidase activator activity 8/2202 57/18639 0.140350877192982 1.18801089918256 0.358856176263019 0.850414683281493 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 3/2202 18/18639 0.166666666666667 1.41076294277929 0.359401203970203 0.850414683281493 GO:0016854 racemase and epimerase activity 3/2202 18/18639 0.166666666666667 1.41076294277929 0.359401203970203 0.850414683281493 GO:0035615 clathrin adaptor activity 3/2202 18/18639 0.166666666666667 1.41076294277929 0.359401203970203 0.850414683281493 GO:0070628 proteasome binding 3/2202 18/18639 0.166666666666667 1.41076294277929 0.359401203970203 0.850414683281493 GO:0033192 calmodulin-dependent protein phosphatase activity 11/2202 81/18639 0.135802469135802 1.14951054596831 0.359453295770161 0.850414683281493 GO:0140791 histone H2AXS140 phosphatase activity 11/2202 81/18639 0.135802469135802 1.14951054596831 0.359453295770161 0.850414683281493 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 11/2202 81/18639 0.135802469135802 1.14951054596831 0.359453295770161 0.850414683281493 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 11/2202 81/18639 0.135802469135802 1.14951054596831 0.359453295770161 0.850414683281493 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 11/2202 81/18639 0.135802469135802 1.14951054596831 0.359453295770161 0.850414683281493 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 11/2202 81/18639 0.135802469135802 1.14951054596831 0.359453295770161 0.850414683281493 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 11/2202 81/18639 0.135802469135802 1.14951054596831 0.359453295770161 0.850414683281493 GO:1990439 MAP kinase serine/threonine phosphatase activity 11/2202 81/18639 0.135802469135802 1.14951054596831 0.359453295770161 0.850414683281493 GO:0043539 protein serine/threonine kinase activator activity 10/2202 73/18639 0.136986301369863 1.15953118584599 0.359705427393216 0.850414683281493 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 4/2202 26/18639 0.153846153846154 1.30224271641165 0.369554908695722 0.85674352286753 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 5/2202 34/18639 0.147058823529412 1.24479083186408 0.374369890769591 0.85674352286753 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 11/2202 82/18639 0.134146341463415 1.13549212467602 0.375099202827114 0.85674352286753 GO:0033549 MAP kinase phosphatase activity 11/2202 82/18639 0.134146341463415 1.13549212467602 0.375099202827114 0.85674352286753 GO:0035198 miRNA binding 6/2202 42/18639 0.142857142857143 1.20922537952511 0.37664607148674 0.85674352286753 GO:0016853 isomerase activity 23/2202 180/18639 0.127777777777778 1.08158492279746 0.377140859749276 0.85674352286753 GO:0032813 tumor necrosis factor receptor superfamily binding 7/2202 50/18639 0.14 1.1850408719346 0.377525524423548 0.85674352286753 GO:0017116 single-stranded DNA helicase activity 8/2202 58/18639 0.137931034482759 1.16752795264493 0.3775638770488 0.85674352286753 GO:0061980 regulatory RNA binding 8/2202 58/18639 0.137931034482759 1.16752795264493 0.3775638770488 0.85674352286753 GO:0031072 heat shock protein binding 17/2202 131/18639 0.129770992366412 1.09845664246937 0.378511520478064 0.85674352286753 GO:0004954 prostanoid receptor activity 2/2202 11/18639 0.181818181818182 1.53901411939559 0.379532161131047 0.85674352286753 GO:0005225 volume-sensitive anion channel activity 2/2202 11/18639 0.181818181818182 1.53901411939559 0.379532161131047 0.85674352286753 GO:0005536 D-glucose binding 2/2202 11/18639 0.181818181818182 1.53901411939559 0.379532161131047 0.85674352286753 GO:0008271 secondary active sulfate transmembrane transporter activity 2/2202 11/18639 0.181818181818182 1.53901411939559 0.379532161131047 0.85674352286753 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 2/2202 11/18639 0.181818181818182 1.53901411939559 0.379532161131047 0.85674352286753 GO:0019107 myristoyltransferase activity 2/2202 11/18639 0.181818181818182 1.53901411939559 0.379532161131047 0.85674352286753 GO:0032050 clathrin heavy chain binding 2/2202 11/18639 0.181818181818182 1.53901411939559 0.379532161131047 0.85674352286753 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 2/2202 11/18639 0.181818181818182 1.53901411939559 0.379532161131047 0.85674352286753 GO:0045294 alpha-catenin binding 2/2202 11/18639 0.181818181818182 1.53901411939559 0.379532161131047 0.85674352286753 GO:0047676 arachidonate-CoA ligase activity 2/2202 11/18639 0.181818181818182 1.53901411939559 0.379532161131047 0.85674352286753 GO:0050786 RAGE receptor binding 2/2202 11/18639 0.181818181818182 1.53901411939559 0.379532161131047 0.85674352286753 GO:0140031 phosphorylation-dependent protein binding 2/2202 11/18639 0.181818181818182 1.53901411939559 0.379532161131047 0.85674352286753 GO:1900750 oligopeptide binding 2/2202 11/18639 0.181818181818182 1.53901411939559 0.379532161131047 0.85674352286753 GO:0035401 histone H3Y41 kinase activity 15/2202 115/18639 0.130434782608696 1.10407534652292 0.382620980374848 0.860335629062035 GO:0140801 histone H2AXY142 kinase activity 15/2202 115/18639 0.130434782608696 1.10407534652292 0.382620980374848 0.860335629062035 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 11/2202 83/18639 0.132530120481928 1.12181149666787 0.39081429313544 0.868179418830459 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 3/2202 19/18639 0.157894736842105 1.33651226158038 0.393168544419751 0.868179418830459 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 3/2202 19/18639 0.157894736842105 1.33651226158038 0.393168544419751 0.868179418830459 GO:0008301 DNA binding, bending 3/2202 19/18639 0.157894736842105 1.33651226158038 0.393168544419751 0.868179418830459 GO:0042577 lipid phosphatase activity 3/2202 19/18639 0.157894736842105 1.33651226158038 0.393168544419751 0.868179418830459 GO:0097001 ceramide binding 3/2202 19/18639 0.157894736842105 1.33651226158038 0.393168544419751 0.868179418830459 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 9/2202 67/18639 0.134328358208955 1.13703281955346 0.394630147391619 0.868179418830459 GO:0004364 glutathione transferase activity 4/2202 27/18639 0.148148148148148 1.2540115046927 0.397677898455255 0.868179418830459 GO:0008266 poly(U) RNA binding 4/2202 27/18639 0.148148148148148 1.2540115046927 0.397677898455255 0.868179418830459 GO:0008320 protein transmembrane transporter activity 4/2202 27/18639 0.148148148148148 1.2540115046927 0.397677898455255 0.868179418830459 GO:0016405 CoA-ligase activity 4/2202 27/18639 0.148148148148148 1.2540115046927 0.397677898455255 0.868179418830459 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 4/2202 27/18639 0.148148148148148 1.2540115046927 0.397677898455255 0.868179418830459 GO:0035255 ionotropic glutamate receptor binding 4/2202 27/18639 0.148148148148148 1.2540115046927 0.397677898455255 0.868179418830459 GO:0030544 Hsp70 protein binding 7/2202 51/18639 0.137254901960784 1.16180477640648 0.397759232324715 0.868179418830459 GO:0048156 tau protein binding 6/2202 43/18639 0.13953488372093 1.18110385907103 0.398747062527067 0.868179418830459 GO:0043015 gamma-tubulin binding 5/2202 35/18639 0.142857142857143 1.20922537952511 0.398954511003031 0.868179418830459 GO:0061631 ubiquitin conjugating enzyme activity 5/2202 35/18639 0.142857142857143 1.20922537952511 0.398954511003031 0.868179418830459 GO:0052689 carboxylic ester hydrolase activity 12/2202 92/18639 0.130434782608696 1.10407534652292 0.403824743713375 0.877116503831129 GO:0017018 myosin phosphatase activity 11/2202 84/18639 0.130952380952381 1.10845659789801 0.40657238975991 0.881418256290824 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 8/2202 60/18639 0.133333333333333 1.12861035422343 0.41510234768666 0.892706497771954 GO:0030159 signaling receptor complex adaptor activity 7/2202 52/18639 0.134615384615385 1.1394623768602 0.41798285312525 0.892706497771954 GO:0051213 dioxygenase activity 12/2202 93/18639 0.129032258064516 1.09220356860332 0.418876473986595 0.892706497771954 GO:0019205 nucleobase-containing compound kinase activity 6/2202 44/18639 0.136363636363636 1.15426058954669 0.420802766189481 0.892706497771954 GO:0000995 RNA polymerase III general transcription initiation factor activity 2/2202 12/18639 0.166666666666667 1.41076294277929 0.42321724988317 0.892706497771954 GO:0004126 cytidine deaminase activity 2/2202 12/18639 0.166666666666667 1.41076294277929 0.42321724988317 0.892706497771954 GO:0016208 AMP binding 2/2202 12/18639 0.166666666666667 1.41076294277929 0.42321724988317 0.892706497771954 GO:0016273 arginine N-methyltransferase activity 2/2202 12/18639 0.166666666666667 1.41076294277929 0.42321724988317 0.892706497771954 GO:0016274 protein-arginine N-methyltransferase activity 2/2202 12/18639 0.166666666666667 1.41076294277929 0.42321724988317 0.892706497771954 GO:0016423 tRNA (guanine) methyltransferase activity 2/2202 12/18639 0.166666666666667 1.41076294277929 0.42321724988317 0.892706497771954 GO:0043047 single-stranded telomeric DNA binding 2/2202 12/18639 0.166666666666667 1.41076294277929 0.42321724988317 0.892706497771954 GO:0045295 gamma-catenin binding 2/2202 12/18639 0.166666666666667 1.41076294277929 0.42321724988317 0.892706497771954 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 2/2202 12/18639 0.166666666666667 1.41076294277929 0.42321724988317 0.892706497771954 GO:0097677 STAT family protein binding 2/2202 12/18639 0.166666666666667 1.41076294277929 0.42321724988317 0.892706497771954 GO:0004869 cysteine-type endopeptidase inhibitor activity 5/2202 36/18639 0.138888888888889 1.17563578564941 0.423433456297402 0.892706497771954 GO:0051540 metal cluster binding 10/2202 77/18639 0.12987012987013 1.09929579956828 0.425983050711061 0.895781967255728 GO:0140664 ATP-dependent DNA damage sensor activity 3/2202 20/18639 0.15 1.26968664850136 0.426451467440282 0.895781967255728 GO:0042826 histone deacetylase binding 16/2202 127/18639 0.125984251968504 1.06640348430561 0.432136236077078 0.90606667016891 GO:0019905 syntaxin binding 8/2202 61/18639 0.131147540983607 1.1101085451378 0.433847285483735 0.907997324263773 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 11/2202 86/18639 0.127906976744186 1.08267853748178 0.438115271451448 0.915262630723116 GO:0004715 non-membrane spanning protein tyrosine kinase activity 6/2202 45/18639 0.133333333333333 1.12861035422343 0.442747492593515 0.923261105244917 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 16/2202 128/18639 0.125 1.05807220708447 0.445065867515825 0.926414278579135 GO:0016782 transferase activity, transferring sulphur-containing groups 9/2202 70/18639 0.128571428571429 1.0883028415726 0.447347067222155 0.929478806940789 GO:0050661 NADP binding 7/2202 54/18639 0.12962962962963 1.09726006660612 0.458195021600515 0.941138405738262 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 3/2202 21/18639 0.142857142857143 1.20922537952511 0.459064843024189 0.941138405738262 GO:0005123 death receptor binding 3/2202 21/18639 0.142857142857143 1.20922537952511 0.459064843024189 0.941138405738262 GO:0019200 carbohydrate kinase activity 3/2202 21/18639 0.142857142857143 1.20922537952511 0.459064843024189 0.941138405738262 GO:0072542 protein phosphatase activator activity 3/2202 21/18639 0.142857142857143 1.20922537952511 0.459064843024189 0.941138405738262 GO:0140312 cargo adaptor activity 3/2202 21/18639 0.142857142857143 1.20922537952511 0.459064843024189 0.941138405738262 GO:1904047 S-adenosyl-L-methionine binding 3/2202 21/18639 0.142857142857143 1.20922537952511 0.459064843024189 0.941138405738262 GO:0019887 protein kinase regulator activity 31/2202 255/18639 0.12156862745098 1.02902708767431 0.46126565893795 0.941138405738262 GO:0030276 clathrin binding 6/2202 46/18639 0.130434782608696 1.10407534652292 0.464519614058505 0.941138405738262 GO:0030291 protein serine/threonine kinase inhibitor activity 6/2202 46/18639 0.130434782608696 1.10407534652292 0.464519614058505 0.941138405738262 GO:0008035 high-density lipoprotein particle binding 2/2202 13/18639 0.153846153846154 1.30224271641165 0.465245095264867 0.941138405738262 GO:0043560 insulin receptor substrate binding 2/2202 13/18639 0.153846153846154 1.30224271641165 0.465245095264867 0.941138405738262 GO:0061459 L-arginine transmembrane transporter activity 2/2202 13/18639 0.153846153846154 1.30224271641165 0.465245095264867 0.941138405738262 GO:0140666 annealing activity 2/2202 13/18639 0.153846153846154 1.30224271641165 0.465245095264867 0.941138405738262 GO:0140852 histone ubiquitin ligase activity 2/2202 13/18639 0.153846153846154 1.30224271641165 0.465245095264867 0.941138405738262 GO:0048306 calcium-dependent protein binding 10/2202 80/18639 0.125 1.05807220708447 0.475561978097413 0.960317597247675 GO:0140313 molecular sequestering activity 7/2202 55/18639 0.127272727272727 1.07730988357691 0.478087711455944 0.963010983892864 GO:0008106 alcohol dehydrogenase (NADP+) activity 4/2202 30/18639 0.133333333333333 1.12861035422343 0.480248297450488 0.963010983892864 GO:0008187 poly-pyrimidine tract binding 4/2202 30/18639 0.133333333333333 1.12861035422343 0.480248297450488 0.963010983892864 GO:0070566 adenylyltransferase activity 4/2202 30/18639 0.133333333333333 1.12861035422343 0.480248297450488 0.963010983892864 GO:0031683 G-protein beta/gamma-subunit complex binding 3/2202 22/18639 0.136363636363636 1.15426058954669 0.490853715388669 0.979150901009689 GO:0050321 tau-protein kinase activity 3/2202 22/18639 0.136363636363636 1.15426058954669 0.490853715388669 0.979150901009689 GO:0070034 telomerase RNA binding 3/2202 22/18639 0.136363636363636 1.15426058954669 0.490853715388669 0.979150901009689 GO:0017124 SH3 domain binding 14/2202 115/18639 0.121739130434783 1.0304703234214 0.495259523213479 0.984648642808926 GO:0030170 pyridoxal phosphate binding 7/2202 56/18639 0.125 1.05807220708447 0.497778965697286 0.984648642808926 GO:0004721 phosphoprotein phosphatase activity 21/2202 175/18639 0.12 1.01574931880109 0.504568430771516 0.984648642808926 GO:0005545 1-phosphatidylinositol binding 2/2202 14/18639 0.142857142857143 1.20922537952511 0.505397489977978 0.984648642808926 GO:0008474 palmitoyl-(protein) hydrolase activity 2/2202 14/18639 0.142857142857143 1.20922537952511 0.505397489977978 0.984648642808926 GO:0016530 metallochaperone activity 2/2202 14/18639 0.142857142857143 1.20922537952511 0.505397489977978 0.984648642808926 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 2/2202 14/18639 0.142857142857143 1.20922537952511 0.505397489977978 0.984648642808926 GO:0032036 myosin heavy chain binding 2/2202 14/18639 0.142857142857143 1.20922537952511 0.505397489977978 0.984648642808926 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 2/2202 14/18639 0.142857142857143 1.20922537952511 0.505397489977978 0.984648642808926 GO:0098599 palmitoyl hydrolase activity 2/2202 14/18639 0.142857142857143 1.20922537952511 0.505397489977978 0.984648642808926 GO:0098847 sequence-specific single stranded DNA binding 2/2202 14/18639 0.142857142857143 1.20922537952511 0.505397489977978 0.984648642808926 GO:1901612 cardiolipin binding 2/2202 14/18639 0.142857142857143 1.20922537952511 0.505397489977978 0.984648642808926 GO:0005310 dicarboxylic acid transmembrane transporter activity 4/2202 31/18639 0.129032258064516 1.09220356860332 0.506811532467143 0.984648642808926 GO:0016878 acid-thiol ligase activity 4/2202 31/18639 0.129032258064516 1.09220356860332 0.506811532467143 0.984648642808926 GO:0140457 protein demethylase activity 4/2202 31/18639 0.129032258064516 1.09220356860332 0.506811532467143 0.984648642808926 GO:0016879 ligase activity, forming carbon-nitrogen bonds 6/2202 48/18639 0.125 1.05807220708447 0.507321145816261 0.984648642808926 GO:0003678 DNA helicase activity 9/2202 74/18639 0.121621621621622 1.02947566094705 0.516449203223763 0.999038568396287 GO:0070279 vitamin B6 binding 7/2202 57/18639 0.12280701754386 1.03950953678474 0.517228156218084 0.999038568396287 GO:0030331 nuclear estrogen receptor binding 5/2202 40/18639 0.125 1.05807220708447 0.518662814271583 0.999038568396287 GO:0032451 demethylase activity 5/2202 40/18639 0.125 1.05807220708447 0.518662814271583 0.999038568396287 GO:0003887 DNA-directed DNA polymerase activity 3/2202 23/18639 0.130434782608696 1.10407534652292 0.521691158431481 0.999038568396287 GO:0004602 glutathione peroxidase activity 3/2202 23/18639 0.130434782608696 1.10407534652292 0.521691158431481 0.999038568396287 GO:0140103 catalytic activity, acting on a glycoprotein 3/2202 23/18639 0.130434782608696 1.10407534652292 0.521691158431481 0.999038568396287 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 3/2202 23/18639 0.130434782608696 1.10407534652292 0.521691158431481 0.999038568396287 GO:0035254 glutamate receptor binding 6/2202 49/18639 0.122448979591837 1.03647889673581 0.528249326169362 0.999999999998779 GO:0022884 macromolecule transmembrane transporter activity 4/2202 32/18639 0.125 1.05807220708447 0.532746965931479 0.999999999998779 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 4/2202 32/18639 0.125 1.05807220708447 0.532746965931479 0.999999999998779 GO:0070717 poly-purine tract binding 4/2202 32/18639 0.125 1.05807220708447 0.532746965931479 0.999999999998779 GO:0015297 antiporter activity 16/2202 135/18639 0.118518518518519 1.00320920375416 0.534477805804086 0.999999999998779 GO:0004812 aminoacyl-tRNA ligase activity 5/2202 41/18639 0.121951219512195 1.03226556788729 0.541453588489873 0.999999999998779 GO:0016875 ligase activity, forming carbon-oxygen bonds 5/2202 41/18639 0.121951219512195 1.03226556788729 0.541453588489873 0.999999999998779 GO:0016877 ligase activity, forming carbon-sulfur bonds 5/2202 41/18639 0.121951219512195 1.03226556788729 0.541453588489873 0.999999999998779 GO:0004089 carbonate dehydratase activity 2/2202 15/18639 0.133333333333333 1.12861035422343 0.543530863914084 0.999999999998779 GO:0004953 icosanoid receptor activity 2/2202 15/18639 0.133333333333333 1.12861035422343 0.543530863914084 0.999999999998779 GO:0010181 FMN binding 2/2202 15/18639 0.133333333333333 1.12861035422343 0.543530863914084 0.999999999998779 GO:0015116 sulfate transmembrane transporter activity 2/2202 15/18639 0.133333333333333 1.12861035422343 0.543530863914084 0.999999999998779 GO:0015556 C4-dicarboxylate transmembrane transporter activity 2/2202 15/18639 0.133333333333333 1.12861035422343 0.543530863914084 0.999999999998779 GO:0015929 hexosaminidase activity 2/2202 15/18639 0.133333333333333 1.12861035422343 0.543530863914084 0.999999999998779 GO:0050780 dopamine receptor binding 2/2202 15/18639 0.133333333333333 1.12861035422343 0.543530863914084 0.999999999998779 GO:0051371 muscle alpha-actinin binding 2/2202 15/18639 0.133333333333333 1.12861035422343 0.543530863914084 0.999999999998779 GO:0140776 protein-containing complex destabilizing activity 2/2202 15/18639 0.133333333333333 1.12861035422343 0.543530863914084 0.999999999998779 GO:0141050 histone H3K deacetylase activity 2/2202 15/18639 0.133333333333333 1.12861035422343 0.543530863914084 0.999999999998779 GO:0141051 histone H4K deacetylase activity 2/2202 15/18639 0.133333333333333 1.12861035422343 0.543530863914084 0.999999999998779 GO:0140789 histone phosphatase activity 16/2202 136/18639 0.117647058823529 0.995832665491265 0.546946698693686 0.999999999998779 GO:0051536 iron-sulfur cluster binding 9/2202 76/18639 0.118421052631579 1.00238419618529 0.549963023678513 0.999999999998779 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 3/2202 24/18639 0.125 1.05807220708447 0.551475933832003 0.999999999998779 GO:0015459 potassium channel regulator activity 7/2202 59/18639 0.11864406779661 1.00427192536831 0.555253422588622 0.999999999998779 GO:0036002 pre-mRNA binding 7/2202 59/18639 0.11864406779661 1.00427192536831 0.555253422588622 0.999999999998779 GO:0019239 deaminase activity 4/2202 33/18639 0.121212121212121 1.02600941293039 0.557984751649722 0.999999999998779 GO:0071889 14-3-3 protein binding 4/2202 33/18639 0.121212121212121 1.02600941293039 0.557984751649722 0.999999999998779 GO:0140311 protein sequestering activity 4/2202 33/18639 0.121212121212121 1.02600941293039 0.557984751649722 0.999999999998779 GO:0030145 manganese ion binding 8/2202 68/18639 0.117647058823529 0.995832665491265 0.561058436235675 0.999999999998779 GO:1990841 promoter-specific chromatin binding 8/2202 68/18639 0.117647058823529 0.995832665491265 0.561058436235675 0.999999999998779 GO:0048487 beta-tubulin binding 5/2202 42/18639 0.119047619047619 1.00768781627092 0.563724874571377 0.999999999998779 GO:0005200 structural constituent of cytoskeleton 13/2202 112/18639 0.116071428571429 0.98249562086415 0.570946739370782 0.999999999998779 GO:0005516 calmodulin binding 24/2202 207/18639 0.115942028985507 0.981400308020377 0.571656777867532 0.999999999998779 GO:0004707 MAP kinase activity 2/2202 16/18639 0.125 1.05807220708447 0.579561707383721 0.999999999998779 GO:0004708 MAP kinase kinase activity 2/2202 16/18639 0.125 1.05807220708447 0.579561707383721 0.999999999998779 GO:0005159 insulin-like growth factor receptor binding 2/2202 16/18639 0.125 1.05807220708447 0.579561707383721 0.999999999998779 GO:0016722 oxidoreductase activity, acting on metal ions 2/2202 16/18639 0.125 1.05807220708447 0.579561707383721 0.999999999998779 GO:0043023 ribosomal large subunit binding 2/2202 16/18639 0.125 1.05807220708447 0.579561707383721 0.999999999998779 GO:0097027 ubiquitin-protein transferase activator activity 2/2202 16/18639 0.125 1.05807220708447 0.579561707383721 0.999999999998779 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 15/2202 130/18639 0.115384615384615 0.97668203730874 0.579625415641941 0.999999999998779 GO:0022804 active transmembrane transporter activity 53/2202 457/18639 0.115973741794311 0.981668743553205 0.579857873562482 0.999999999998779 GO:0008139 nuclear localization sequence binding 3/2202 25/18639 0.12 1.01574931880109 0.580130061616047 0.999999999998779 GO:0008483 transaminase activity 3/2202 25/18639 0.12 1.01574931880109 0.580130061616047 0.999999999998779 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 3/2202 25/18639 0.12 1.01574931880109 0.580130061616047 0.999999999998779 GO:0019211 phosphatase activator activity 3/2202 25/18639 0.12 1.01574931880109 0.580130061616047 0.999999999998779 GO:0008376 acetylgalactosaminyltransferase activity 4/2202 34/18639 0.117647058823529 0.995832665491265 0.582466733100406 0.999999999998779 GO:0016831 carboxy-lyase activity 4/2202 34/18639 0.117647058823529 0.995832665491265 0.582466733100406 0.999999999998779 GO:0140767 enzyme-substrate adaptor activity 16/2202 139/18639 0.115107913669065 0.974339874149727 0.5836530969258 0.999999999998779 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 14/2202 122/18639 0.114754098360656 0.971344976995578 0.588278833358059 0.999999999998779 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 6/2202 52/18639 0.115384615384615 0.97668203730874 0.588631966062234 0.999999999998779 GO:0097110 scaffold protein binding 8/2202 70/18639 0.114285714285714 0.967380303620086 0.5951653613009 0.999999999998779 GO:0033293 monocarboxylic acid binding 9/2202 79/18639 0.113924050632911 0.964318973545339 0.598388074501393 0.999999999998779 GO:0016229 steroid dehydrogenase activity 4/2202 35/18639 0.114285714285714 0.967380303620086 0.606145729500067 0.999999999998779 GO:0005112 Notch binding 3/2202 26/18639 0.115384615384615 0.97668203730874 0.607596385910002 0.999999999998779 GO:0008143 poly(A) binding 3/2202 26/18639 0.115384615384615 0.97668203730874 0.607596385910002 0.999999999998779 GO:0051139 metal cation:proton antiporter activity 3/2202 26/18639 0.115384615384615 0.97668203730874 0.607596385910002 0.999999999998779 GO:0120014 phospholipid transfer activity 3/2202 26/18639 0.115384615384615 0.97668203730874 0.607596385910002 0.999999999998779 GO:0016860 intramolecular oxidoreductase activity 6/2202 53/18639 0.113207547169811 0.958254074340651 0.607843125613122 0.999999999998779 GO:0001221 transcription coregulator binding 13/2202 115/18639 0.11304347826087 0.956865300319867 0.610635356485751 0.999999999998779 GO:0140299 molecular sensor activity 8/2202 71/18639 0.112676056338028 0.953755228921211 0.611718121212509 0.999999999998779 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 2/2202 17/18639 0.117647058823529 0.995832665491265 0.613454394479712 0.999999999998779 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 2/2202 17/18639 0.117647058823529 0.995832665491265 0.613454394479712 0.999999999998779 GO:0005092 GDP-dissociation inhibitor activity 2/2202 17/18639 0.117647058823529 0.995832665491265 0.613454394479712 0.999999999998779 GO:0016018 cyclosporin A binding 2/2202 17/18639 0.117647058823529 0.995832665491265 0.613454394479712 0.999999999998779 GO:0019198 transmembrane receptor protein phosphatase activity 2/2202 17/18639 0.117647058823529 0.995832665491265 0.613454394479712 0.999999999998779 GO:0032977 membrane insertase activity 2/2202 17/18639 0.117647058823529 0.995832665491265 0.613454394479712 0.999999999998779 GO:0070402 NADPH binding 2/2202 17/18639 0.117647058823529 0.995832665491265 0.613454394479712 0.999999999998779 GO:1990226 histone methyltransferase binding 2/2202 17/18639 0.117647058823529 0.995832665491265 0.613454394479712 0.999999999998779 GO:0003727 single-stranded RNA binding 10/2202 89/18639 0.112359550561798 0.951076141199522 0.616289066160889 0.999999999998779 GO:0051539 4 iron, 4 sulfur cluster binding 5/2202 45/18639 0.111111111111111 0.940508628519528 0.627012775488379 0.999999999998779 GO:0005518 collagen binding 8/2202 72/18639 0.111111111111111 0.940508628519528 0.627911536333854 0.999999999998779 GO:0004033 aldo-keto reductase (NADPH) activity 4/2202 36/18639 0.111111111111111 0.940508628519528 0.6289847636504 0.999999999998779 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 4/2202 36/18639 0.111111111111111 0.940508628519528 0.6289847636504 0.999999999998779 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 4/2202 36/18639 0.111111111111111 0.940508628519528 0.6289847636504 0.999999999998779 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 4/2202 36/18639 0.111111111111111 0.940508628519528 0.6289847636504 0.999999999998779 GO:0001671 ATPase activator activity 3/2202 27/18639 0.111111111111111 0.940508628519528 0.633836196841845 0.999999999998779 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 3/2202 27/18639 0.111111111111111 0.940508628519528 0.633836196841845 0.999999999998779 GO:1990782 protein tyrosine kinase binding 13/2202 117/18639 0.111111111111111 0.940508628519528 0.636106777473133 0.999999999998779 GO:0072341 modified amino acid binding 10/2202 91/18639 0.10989010989011 0.930173368865467 0.644912385045925 0.999999999998779 GO:0000900 mRNA regulatory element binding translation repressor activity 2/2202 18/18639 0.111111111111111 0.940508628519528 0.645211043293401 0.999999999998779 GO:0008409 5'-3' exonuclease activity 2/2202 18/18639 0.111111111111111 0.940508628519528 0.645211043293401 0.999999999998779 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 2/2202 18/18639 0.111111111111111 0.940508628519528 0.645211043293401 0.999999999998779 GO:0017075 syntaxin-1 binding 2/2202 18/18639 0.111111111111111 0.940508628519528 0.645211043293401 0.999999999998779 GO:0031690 adrenergic receptor binding 2/2202 18/18639 0.111111111111111 0.940508628519528 0.645211043293401 0.999999999998779 GO:0050811 GABA receptor binding 2/2202 18/18639 0.111111111111111 0.940508628519528 0.645211043293401 0.999999999998779 GO:1901611 phosphatidylglycerol binding 2/2202 18/18639 0.111111111111111 0.940508628519528 0.645211043293401 0.999999999998779 GO:1990381 ubiquitin-specific protease binding 2/2202 18/18639 0.111111111111111 0.940508628519528 0.645211043293401 0.999999999998779 GO:0046625 sphingolipid binding 3/2202 28/18639 0.107142857142857 0.90691903464383 0.658826952170144 0.999999999998779 GO:0051393 alpha-actinin binding 3/2202 28/18639 0.107142857142857 0.90691903464383 0.658826952170144 0.999999999998779 GO:0051537 2 iron, 2 sulfur cluster binding 3/2202 28/18639 0.107142857142857 0.90691903464383 0.658826952170144 0.999999999998779 GO:0141052 histone H3 demethylase activity 3/2202 28/18639 0.107142857142857 0.90691903464383 0.658826952170144 0.999999999998779 GO:0048029 monosaccharide binding 8/2202 74/18639 0.108108108108108 0.915089476397378 0.65915715094787 0.999999999998779 GO:0031490 chromatin DNA binding 14/2202 128/18639 0.109375 0.92581318119891 0.661713272333143 0.999999999998779 GO:0043495 protein-membrane adaptor activity 5/2202 47/18639 0.106382978723404 0.900486984752739 0.665967969521062 0.999999999998779 GO:0043531 ADP binding 4/2202 38/18639 0.105263157894737 0.891008174386921 0.672041200288585 0.999999999998779 GO:0044183 protein folding chaperone 8/2202 75/18639 0.106666666666667 0.902888283378747 0.674183158398523 0.999999999998779 GO:0042800 histone H3K4 methyltransferase activity 2/2202 19/18639 0.105263157894737 0.891008174386921 0.674863101984418 0.999999999998779 GO:0050145 nucleoside monophosphate kinase activity 2/2202 19/18639 0.105263157894737 0.891008174386921 0.674863101984418 0.999999999998779 GO:0140036 ubiquitin-modified protein reader activity 2/2202 19/18639 0.105263157894737 0.891008174386921 0.674863101984418 0.999999999998779 GO:0008235 metalloexopeptidase activity 7/2202 66/18639 0.106060606060606 0.897758236314095 0.676223386700042 0.999999999998779 GO:0003785 actin monomer binding 3/2202 29/18639 0.103448275862069 0.875645964483698 0.682560128456593 0.999999999998779 GO:0043236 laminin binding 3/2202 29/18639 0.103448275862069 0.875645964483698 0.682560128456593 0.999999999998779 GO:0036121 double-stranded DNA helicase activity 5/2202 48/18639 0.104166666666667 0.881726839237057 0.684415274603016 0.999999999998779 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 4/2202 39/18639 0.102564102564103 0.868161810941102 0.692228350539727 0.999999999998779 GO:0050660 flavin adenine dinucleotide binding 9/2202 86/18639 0.104651162790698 0.885827894303276 0.700336584862231 0.999999999998779 GO:0000339 RNA cap binding 2/2202 20/18639 0.1 0.846457765667575 0.702464394711545 0.999999999998779 GO:0015464 acetylcholine receptor activity 2/2202 20/18639 0.1 0.846457765667575 0.702464394711545 0.999999999998779 GO:0030627 pre-mRNA 5'-splice site binding 2/2202 20/18639 0.1 0.846457765667575 0.702464394711545 0.999999999998779 GO:0031418 L-ascorbic acid binding 2/2202 20/18639 0.1 0.846457765667575 0.702464394711545 0.999999999998779 GO:0061608 nuclear import signal receptor activity 2/2202 20/18639 0.1 0.846457765667575 0.702464394711545 0.999999999998779 GO:0032452 histone demethylase activity 3/2202 30/18639 0.1 0.846457765667575 0.705039220790605 0.999999999998779 GO:0019842 vitamin binding 16/2202 150/18639 0.106666666666667 0.902888283378747 0.706011149122174 0.999999999998779 GO:0050997 quaternary ammonium group binding 4/2202 40/18639 0.1 0.846457765667575 0.711513410125076 0.999999999998779 GO:0140662 ATP-dependent protein folding chaperone 4/2202 40/18639 0.1 0.846457765667575 0.711513410125076 0.999999999998779 GO:0001786 phosphatidylserine binding 6/2202 59/18639 0.101694915254237 0.860804507458551 0.711867925817041 0.999999999998779 GO:0004879 nuclear receptor activity 6/2202 59/18639 0.101694915254237 0.860804507458551 0.711867925817041 0.999999999998779 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 6/2202 59/18639 0.101694915254237 0.860804507458551 0.711867925817041 0.999999999998779 GO:0003680 minor groove of adenine-thymine-rich DNA binding 1/2202 10/18639 0.1 0.846457765667575 0.715646255251304 0.999999999998779 GO:0004382 GDP phosphatase activity 1/2202 10/18639 0.1 0.846457765667575 0.715646255251304 0.999999999998779 GO:0004445 inositol-polyphosphate 5-phosphatase activity 1/2202 10/18639 0.1 0.846457765667575 0.715646255251304 0.999999999998779 GO:0004862 cAMP-dependent protein kinase inhibitor activity 1/2202 10/18639 0.1 0.846457765667575 0.715646255251304 0.999999999998779 GO:0005345 purine nucleobase transmembrane transporter activity 1/2202 10/18639 0.1 0.846457765667575 0.715646255251304 0.999999999998779 GO:0008140 cAMP response element binding protein binding 1/2202 10/18639 0.1 0.846457765667575 0.715646255251304 0.999999999998779 GO:0008239 dipeptidyl-peptidase activity 1/2202 10/18639 0.1 0.846457765667575 0.715646255251304 0.999999999998779 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 1/2202 10/18639 0.1 0.846457765667575 0.715646255251304 0.999999999998779 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 1/2202 10/18639 0.1 0.846457765667575 0.715646255251304 0.999999999998779 GO:0008641 ubiquitin-like modifier activating enzyme activity 1/2202 10/18639 0.1 0.846457765667575 0.715646255251304 0.999999999998779 GO:0015187 glycine transmembrane transporter activity 1/2202 10/18639 0.1 0.846457765667575 0.715646255251304 0.999999999998779 GO:0015279 store-operated calcium channel activity 1/2202 10/18639 0.1 0.846457765667575 0.715646255251304 0.999999999998779 GO:0015643 toxic substance binding 1/2202 10/18639 0.1 0.846457765667575 0.715646255251304 0.999999999998779 GO:0015924 mannosyl-oligosaccharide mannosidase activity 1/2202 10/18639 0.1 0.846457765667575 0.715646255251304 0.999999999998779 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 1/2202 10/18639 0.1 0.846457765667575 0.715646255251304 0.999999999998779 GO:0016868 intramolecular phosphotransferase activity 1/2202 10/18639 0.1 0.846457765667575 0.715646255251304 0.999999999998779 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 1/2202 10/18639 0.1 0.846457765667575 0.715646255251304 0.999999999998779 GO:0030957 Tat protein binding 1/2202 10/18639 0.1 0.846457765667575 0.715646255251304 0.999999999998779 GO:0031419 cobalamin binding 1/2202 10/18639 0.1 0.846457765667575 0.715646255251304 0.999999999998779 GO:0031956 medium-chain fatty acid-CoA ligase activity 1/2202 10/18639 0.1 0.846457765667575 0.715646255251304 0.999999999998779 GO:0035256 G protein-coupled glutamate receptor binding 1/2202 10/18639 0.1 0.846457765667575 0.715646255251304 0.999999999998779 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 1/2202 10/18639 0.1 0.846457765667575 0.715646255251304 0.999999999998779 GO:0042166 acetylcholine binding 1/2202 10/18639 0.1 0.846457765667575 0.715646255251304 0.999999999998779 GO:0042975 peroxisome proliferator activated receptor binding 1/2202 10/18639 0.1 0.846457765667575 0.715646255251304 0.999999999998779 GO:0050308 sugar-phosphatase activity 1/2202 10/18639 0.1 0.846457765667575 0.715646255251304 0.999999999998779 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 1/2202 10/18639 0.1 0.846457765667575 0.715646255251304 0.999999999998779 GO:0051864 histone H3K36 demethylase activity 1/2202 10/18639 0.1 0.846457765667575 0.715646255251304 0.999999999998779 GO:0070097 delta-catenin binding 1/2202 10/18639 0.1 0.846457765667575 0.715646255251304 0.999999999998779 GO:0070513 death domain binding 1/2202 10/18639 0.1 0.846457765667575 0.715646255251304 0.999999999998779 GO:0070739 protein-glutamic acid ligase activity 1/2202 10/18639 0.1 0.846457765667575 0.715646255251304 0.999999999998779 GO:0070740 tubulin-glutamic acid ligase activity 1/2202 10/18639 0.1 0.846457765667575 0.715646255251304 0.999999999998779 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 1/2202 10/18639 0.1 0.846457765667575 0.715646255251304 0.999999999998779 GO:0098505 G-rich strand telomeric DNA binding 1/2202 10/18639 0.1 0.846457765667575 0.715646255251304 0.999999999998779 GO:0140940 histone H2A methyltransferase activity 1/2202 10/18639 0.1 0.846457765667575 0.715646255251304 0.999999999998779 GO:1905394 retromer complex binding 1/2202 10/18639 0.1 0.846457765667575 0.715646255251304 0.999999999998779 GO:1990259 histone H2AQ104 methyltransferase activity 1/2202 10/18639 0.1 0.846457765667575 0.715646255251304 0.999999999998779 GO:1990757 ubiquitin ligase activator activity 1/2202 10/18639 0.1 0.846457765667575 0.715646255251304 0.999999999998779 GO:1990763 arrestin family protein binding 1/2202 10/18639 0.1 0.846457765667575 0.715646255251304 0.999999999998779 GO:0098531 ligand-modulated transcription factor activity 6/2202 60/18639 0.1 0.846457765667575 0.727212812917234 0.999999999998779 GO:0015174 basic amino acid transmembrane transporter activity 2/2202 21/18639 0.0952380952380952 0.806150253016738 0.728085400152319 0.999999999998779 GO:0005048 signal sequence binding 5/2202 51/18639 0.0980392156862745 0.829860554576054 0.735533839779023 0.999999999998779 GO:0061134 peptidase regulator activity 24/2202 226/18639 0.106194690265487 0.898893202478841 0.741748155482576 0.999999999998779 GO:0071813 lipoprotein particle binding 3/2202 32/18639 0.09375 0.793554155313351 0.74629834331181 0.999999999998779 GO:0071814 protein-lipid complex binding 3/2202 32/18639 0.09375 0.793554155313351 0.74629834331181 0.999999999998779 GO:0140142 nucleocytoplasmic carrier activity 3/2202 32/18639 0.09375 0.793554155313351 0.74629834331181 0.999999999998779 GO:0016859 cis-trans isomerase activity 4/2202 42/18639 0.0952380952380952 0.806150253016738 0.74739019056367 0.999999999998779 GO:0000099 sulfur amino acid transmembrane transporter activity 1/2202 11/18639 0.0909090909090909 0.769507059697795 0.74925766466333 0.999999999998779 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 1/2202 11/18639 0.0909090909090909 0.769507059697795 0.74925766466333 0.999999999998779 GO:0002162 dystroglycan binding 1/2202 11/18639 0.0909090909090909 0.769507059697795 0.74925766466333 0.999999999998779 GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity 1/2202 11/18639 0.0909090909090909 0.769507059697795 0.74925766466333 0.999999999998779 GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity 1/2202 11/18639 0.0909090909090909 0.769507059697795 0.74925766466333 0.999999999998779 GO:0008172 S-methyltransferase activity 1/2202 11/18639 0.0909090909090909 0.769507059697795 0.74925766466333 0.999999999998779 GO:0008199 ferric iron binding 1/2202 11/18639 0.0909090909090909 0.769507059697795 0.74925766466333 0.999999999998779 GO:0008526 phosphatidylinositol transfer activity 1/2202 11/18639 0.0909090909090909 0.769507059697795 0.74925766466333 0.999999999998779 GO:0010854 adenylate cyclase regulator activity 1/2202 11/18639 0.0909090909090909 0.769507059697795 0.74925766466333 0.999999999998779 GO:0015205 nucleobase transmembrane transporter activity 1/2202 11/18639 0.0909090909090909 0.769507059697795 0.74925766466333 0.999999999998779 GO:0016176 superoxide-generating NADPH oxidase activator activity 1/2202 11/18639 0.0909090909090909 0.769507059697795 0.74925766466333 0.999999999998779 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 1/2202 11/18639 0.0909090909090909 0.769507059697795 0.74925766466333 0.999999999998779 GO:0019203 carbohydrate phosphatase activity 1/2202 11/18639 0.0909090909090909 0.769507059697795 0.74925766466333 0.999999999998779 GO:0019215 intermediate filament binding 1/2202 11/18639 0.0909090909090909 0.769507059697795 0.74925766466333 0.999999999998779 GO:0035252 UDP-xylosyltransferase activity 1/2202 11/18639 0.0909090909090909 0.769507059697795 0.74925766466333 0.999999999998779 GO:0042285 xylosyltransferase activity 1/2202 11/18639 0.0909090909090909 0.769507059697795 0.74925766466333 0.999999999998779 GO:0043855 cyclic nucleotide-activated monoatomic ion channel activity 1/2202 11/18639 0.0909090909090909 0.769507059697795 0.74925766466333 0.999999999998779 GO:0048101 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity 1/2202 11/18639 0.0909090909090909 0.769507059697795 0.74925766466333 0.999999999998779 GO:0050998 nitric-oxide synthase binding 1/2202 11/18639 0.0909090909090909 0.769507059697795 0.74925766466333 0.999999999998779 GO:0097493 structural molecule activity conferring elasticity 1/2202 11/18639 0.0909090909090909 0.769507059697795 0.74925766466333 0.999999999998779 GO:0180030 inositol phosphate kinase activity 1/2202 11/18639 0.0909090909090909 0.769507059697795 0.74925766466333 0.999999999998779 GO:0016881 acid-amino acid ligase activity 2/2202 22/18639 0.0909090909090909 0.769507059697795 0.751808568628684 0.999999999998779 GO:0030021 extracellular matrix structural constituent conferring compression resistance 2/2202 22/18639 0.0909090909090909 0.769507059697795 0.751808568628684 0.999999999998779 GO:0140035 ubiquitin-like protein reader activity 2/2202 22/18639 0.0909090909090909 0.769507059697795 0.751808568628684 0.999999999998779 GO:0005507 copper ion binding 6/2202 63/18639 0.0952380952380952 0.806150253016738 0.769751907754808 0.999999999998779 GO:1901681 sulfur compound binding 29/2202 275/18639 0.105454545454545 0.892628189249443 0.770500946667126 0.999999999998779 GO:0019209 kinase activator activity 15/2202 148/18639 0.101351351351351 0.857896384122542 0.773270819403012 0.999999999998779 GO:0004022 alcohol dehydrogenase (NAD+) activity 2/2202 23/18639 0.0869565217391304 0.736050231015282 0.773724512456989 0.999999999998779 GO:0043274 phospholipase binding 2/2202 23/18639 0.0869565217391304 0.736050231015282 0.773724512456989 0.999999999998779 GO:0003995 acyl-CoA dehydrogenase activity 1/2202 12/18639 0.0833333333333333 0.705381471389646 0.778897702370617 0.999999999998779 GO:0004000 adenosine deaminase activity 1/2202 12/18639 0.0833333333333333 0.705381471389646 0.778897702370617 0.999999999998779 GO:0004032 aldose reductase (NADPH) activity 1/2202 12/18639 0.0833333333333333 0.705381471389646 0.778897702370617 0.999999999998779 GO:0005049 nuclear export signal receptor activity 1/2202 12/18639 0.0833333333333333 0.705381471389646 0.778897702370617 0.999999999998779 GO:0005165 neurotrophin receptor binding 1/2202 12/18639 0.0833333333333333 0.705381471389646 0.778897702370617 0.999999999998779 GO:0008179 adenylate cyclase binding 1/2202 12/18639 0.0833333333333333 0.705381471389646 0.778897702370617 0.999999999998779 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 1/2202 12/18639 0.0833333333333333 0.705381471389646 0.778897702370617 0.999999999998779 GO:0008603 cAMP-dependent protein kinase regulator activity 1/2202 12/18639 0.0833333333333333 0.705381471389646 0.778897702370617 0.999999999998779 GO:0010853 cyclase activator activity 1/2202 12/18639 0.0833333333333333 0.705381471389646 0.778897702370617 0.999999999998779 GO:0015368 calcium:monoatomic cation antiporter activity 1/2202 12/18639 0.0833333333333333 0.705381471389646 0.778897702370617 0.999999999998779 GO:0016840 carbon-nitrogen lyase activity 1/2202 12/18639 0.0833333333333333 0.705381471389646 0.778897702370617 0.999999999998779 GO:0017166 vinculin binding 1/2202 12/18639 0.0833333333333333 0.705381471389646 0.778897702370617 0.999999999998779 GO:0031543 peptidyl-proline dioxygenase activity 1/2202 12/18639 0.0833333333333333 0.705381471389646 0.778897702370617 0.999999999998779 GO:0035014 phosphatidylinositol 3-kinase regulator activity 1/2202 12/18639 0.0833333333333333 0.705381471389646 0.778897702370617 0.999999999998779 GO:0035259 nuclear glucocorticoid receptor binding 1/2202 12/18639 0.0833333333333333 0.705381471389646 0.778897702370617 0.999999999998779 GO:0036009 protein-glutamine N-methyltransferase activity 1/2202 12/18639 0.0833333333333333 0.705381471389646 0.778897702370617 0.999999999998779 GO:0042301 phosphate ion binding 1/2202 12/18639 0.0833333333333333 0.705381471389646 0.778897702370617 0.999999999998779 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 1/2202 12/18639 0.0833333333333333 0.705381471389646 0.778897702370617 0.999999999998779 GO:0070008 serine-type exopeptidase activity 1/2202 12/18639 0.0833333333333333 0.705381471389646 0.778897702370617 0.999999999998779 GO:0070410 co-SMAD binding 1/2202 12/18639 0.0833333333333333 0.705381471389646 0.778897702370617 0.999999999998779 GO:0140829 bicarbonate:monoatomic anion antiporter activity 1/2202 12/18639 0.0833333333333333 0.705381471389646 0.778897702370617 0.999999999998779 GO:0140900 chloride:bicarbonate antiporter activity 1/2202 12/18639 0.0833333333333333 0.705381471389646 0.778897702370617 0.999999999998779 GO:1990247 N6-methyladenosine-containing RNA reader activity 1/2202 12/18639 0.0833333333333333 0.705381471389646 0.778897702370617 0.999999999998779 GO:1990459 transferrin receptor binding 1/2202 12/18639 0.0833333333333333 0.705381471389646 0.778897702370617 0.999999999998779 GO:1990817 poly(A) RNA polymerase activity 1/2202 12/18639 0.0833333333333333 0.705381471389646 0.778897702370617 0.999999999998779 GO:0008238 exopeptidase activity 10/2202 102/18639 0.0980392156862745 0.829860554576054 0.779200244315594 0.999999999998779 GO:0043014 alpha-tubulin binding 4/2202 44/18639 0.0909090909090909 0.769507059697795 0.779747475904265 0.999999999998779 GO:0140463 chromatin-protein adaptor activity 5/2202 54/18639 0.0925925925925926 0.78375719043294 0.780329653254074 0.999999999998779 GO:0052866 phosphatidylinositol phosphate phosphatase activity 3/2202 34/18639 0.0882352941176471 0.746874499118448 0.782806764030692 0.999999999998779 GO:0016247 channel regulator activity 17/2202 168/18639 0.101190476190476 0.856534643830284 0.786181214240158 0.999999999998779 GO:0008374 O-acyltransferase activity 5/2202 55/18639 0.0909090909090909 0.769507059697795 0.793889809691578 0.999999999998779 GO:0004622 lysophospholipase activity 2/2202 24/18639 0.0833333333333333 0.705381471389646 0.793928928695624 0.999999999998779 GO:0015149 hexose transmembrane transporter activity 2/2202 24/18639 0.0833333333333333 0.705381471389646 0.793928928695624 0.999999999998779 GO:0015295 solute:proton symporter activity 2/2202 24/18639 0.0833333333333333 0.705381471389646 0.793928928695624 0.999999999998779 GO:0030552 cAMP binding 2/2202 24/18639 0.0833333333333333 0.705381471389646 0.793928928695624 0.999999999998779 GO:0035035 histone acetyltransferase binding 2/2202 24/18639 0.0833333333333333 0.705381471389646 0.793928928695624 0.999999999998779 GO:0055056 D-glucose transmembrane transporter activity 2/2202 24/18639 0.0833333333333333 0.705381471389646 0.793928928695624 0.999999999998779 GO:0099106 ion channel regulator activity 16/2202 160/18639 0.1 0.846457765667575 0.796159328462767 0.999999999998779 GO:0005154 epidermal growth factor receptor binding 3/2202 35/18639 0.0857142857142857 0.725535227715064 0.799368736017938 0.999999999998779 GO:0034061 DNA polymerase activity 3/2202 35/18639 0.0857142857142857 0.725535227715064 0.799368736017938 0.999999999998779 GO:0140566 histone reader activity 3/2202 35/18639 0.0857142857142857 0.725535227715064 0.799368736017938 0.999999999998779 GO:0141108 transporter regulator activity 17/2202 170/18639 0.1 0.846457765667575 0.801729090261729 0.999999999998779 GO:0004866 endopeptidase inhibitor activity 16/2202 161/18639 0.0993788819875776 0.841200264017466 0.80397876197421 0.999999999998779 GO:0002161 aminoacyl-tRNA editing activity 1/2202 13/18639 0.0769230769230769 0.651121358205827 0.80503541962943 0.999999999998779 GO:0005542 folic acid binding 1/2202 13/18639 0.0769230769230769 0.651121358205827 0.80503541962943 0.999999999998779 GO:0008417 fucosyltransferase activity 1/2202 13/18639 0.0769230769230769 0.651121358205827 0.80503541962943 0.999999999998779 GO:0015651 quaternary ammonium group transmembrane transporter activity 1/2202 13/18639 0.0769230769230769 0.651121358205827 0.80503541962943 0.999999999998779 GO:0017154 semaphorin receptor activity 1/2202 13/18639 0.0769230769230769 0.651121358205827 0.80503541962943 0.999999999998779 GO:0035325 Toll-like receptor binding 1/2202 13/18639 0.0769230769230769 0.651121358205827 0.80503541962943 0.999999999998779 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 1/2202 13/18639 0.0769230769230769 0.651121358205827 0.80503541962943 0.999999999998779 GO:0071837 HMG box domain binding 1/2202 13/18639 0.0769230769230769 0.651121358205827 0.80503541962943 0.999999999998779 GO:0016209 antioxidant activity 8/2202 86/18639 0.0930232558139535 0.787402572714023 0.811361038888036 0.999999999998779 GO:0000030 mannosyltransferase activity 2/2202 25/18639 0.08 0.67716621253406 0.812520134528631 0.999999999998779 GO:0016791 phosphatase activity 28/2202 273/18639 0.102564102564103 0.868161810941102 0.814204086156767 0.999999999998779 GO:0004601 peroxidase activity 5/2202 57/18639 0.087719298245614 0.742506811989101 0.819029708346673 0.999999999998779 GO:0061749 forked DNA-dependent helicase activity 4/2202 47/18639 0.0851063829787234 0.720389587802191 0.822006320787523 0.999999999998779 GO:1990518 single-stranded 3'-5' DNA helicase activity 4/2202 47/18639 0.0851063829787234 0.720389587802191 0.822006320787523 0.999999999998779 GO:0004705 JUN kinase activity 1/2202 14/18639 0.0714285714285714 0.604612689762554 0.82808449114108 0.999999999998779 GO:0005313 L-glutamate transmembrane transporter activity 1/2202 14/18639 0.0714285714285714 0.604612689762554 0.82808449114108 0.999999999998779 GO:0015386 potassium:proton antiporter activity 1/2202 14/18639 0.0714285714285714 0.604612689762554 0.82808449114108 0.999999999998779 GO:0015926 glucosidase activity 1/2202 14/18639 0.0714285714285714 0.604612689762554 0.82808449114108 0.999999999998779 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 1/2202 14/18639 0.0714285714285714 0.604612689762554 0.82808449114108 0.999999999998779 GO:0034236 protein kinase A catalytic subunit binding 1/2202 14/18639 0.0714285714285714 0.604612689762554 0.82808449114108 0.999999999998779 GO:0042813 Wnt receptor activity 1/2202 14/18639 0.0714285714285714 0.604612689762554 0.82808449114108 0.999999999998779 GO:0043176 amine binding 1/2202 14/18639 0.0714285714285714 0.604612689762554 0.82808449114108 0.999999999998779 GO:0046030 inositol trisphosphate phosphatase activity 1/2202 14/18639 0.0714285714285714 0.604612689762554 0.82808449114108 0.999999999998779 GO:1901474 azole transmembrane transporter activity 1/2202 14/18639 0.0714285714285714 0.604612689762554 0.82808449114108 0.999999999998779 GO:1990825 sequence-specific mRNA binding 1/2202 14/18639 0.0714285714285714 0.604612689762554 0.82808449114108 0.999999999998779 GO:0022829 wide pore channel activity 3/2202 37/18639 0.0810810810810811 0.686317107298034 0.829320123288898 0.999999999998779 GO:0042805 actinin binding 3/2202 37/18639 0.0810810810810811 0.686317107298034 0.829320123288898 0.999999999998779 GO:0004435 phosphatidylinositol phospholipase C activity 2/2202 26/18639 0.0769230769230769 0.651121358205827 0.829597113580183 0.999999999998779 GO:0015145 monosaccharide transmembrane transporter activity 2/2202 26/18639 0.0769230769230769 0.651121358205827 0.829597113580183 0.999999999998779 GO:0030507 spectrin binding 2/2202 26/18639 0.0769230769230769 0.651121358205827 0.829597113580183 0.999999999998779 GO:0070006 metalloaminopeptidase activity 2/2202 26/18639 0.0769230769230769 0.651121358205827 0.829597113580183 0.999999999998779 GO:0097602 cullin family protein binding 2/2202 26/18639 0.0769230769230769 0.651121358205827 0.829597113580183 0.999999999998779 GO:0009378 four-way junction helicase activity 4/2202 48/18639 0.0833333333333333 0.705381471389646 0.834514597713387 0.999999999998779 GO:0043138 3'-5' DNA helicase activity 4/2202 48/18639 0.0833333333333333 0.705381471389646 0.834514597713387 0.999999999998779 GO:0070888 E-box binding 5/2202 59/18639 0.0847457627118644 0.717337089548792 0.841639433473664 0.999999999998779 GO:0004683 calcium/calmodulin-dependent protein kinase activity 2/2202 27/18639 0.0740740740740741 0.627005752346352 0.84525798691925 0.999999999998779 GO:0001222 transcription corepressor binding 4/2202 49/18639 0.0816326530612245 0.690985931157204 0.84627932594508 0.999999999998779 GO:0004559 alpha-mannosidase activity 1/2202 15/18639 0.0666666666666667 0.564305177111717 0.848409750228722 0.999999999998779 GO:0004865 protein serine/threonine phosphatase inhibitor activity 1/2202 15/18639 0.0666666666666667 0.564305177111717 0.848409750228722 0.999999999998779 GO:0005041 low-density lipoprotein particle receptor activity 1/2202 15/18639 0.0666666666666667 0.564305177111717 0.848409750228722 0.999999999998779 GO:0005402 carbohydrate:monoatomic cation symporter activity 1/2202 15/18639 0.0666666666666667 0.564305177111717 0.848409750228722 0.999999999998779 GO:0008242 omega peptidase activity 1/2202 15/18639 0.0666666666666667 0.564305177111717 0.848409750228722 0.999999999998779 GO:0030553 cGMP binding 1/2202 15/18639 0.0666666666666667 0.564305177111717 0.848409750228722 0.999999999998779 GO:0033130 acetylcholine receptor binding 1/2202 15/18639 0.0666666666666667 0.564305177111717 0.848409750228722 0.999999999998779 GO:0047372 monoacylglycerol lipase activity 1/2202 15/18639 0.0666666666666667 0.564305177111717 0.848409750228722 0.999999999998779 GO:0048531 beta-1,3-galactosyltransferase activity 1/2202 15/18639 0.0666666666666667 0.564305177111717 0.848409750228722 0.999999999998779 GO:0030295 protein kinase activator activity 13/2202 139/18639 0.0935251798561151 0.791651147746653 0.850499725432964 0.999999999998779 GO:0031406 carboxylic acid binding 18/2202 187/18639 0.0962566844919786 0.814772180856489 0.85309713502293 0.999999999998779 GO:0030414 peptidase inhibitor activity 16/2202 169/18639 0.0946745562130177 0.801380133176402 0.858873285806076 0.999999999998779 GO:0046875 ephrin receptor binding 2/2202 28/18639 0.0714285714285714 0.604612689762554 0.859598835746105 0.999999999998779 GO:0051119 sugar transmembrane transporter activity 2/2202 28/18639 0.0714285714285714 0.604612689762554 0.859598835746105 0.999999999998779 GO:0043177 organic acid binding 18/2202 189/18639 0.0952380952380952 0.806150253016738 0.864576196144322 0.999999999998779 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 1/2202 16/18639 0.0625 0.529036103542234 0.866332953085056 0.999999999998779 GO:0008296 3'-5'-DNA exonuclease activity 1/2202 16/18639 0.0625 0.529036103542234 0.866332953085056 0.999999999998779 GO:0015385 sodium:proton antiporter activity 1/2202 16/18639 0.0625 0.529036103542234 0.866332953085056 0.999999999998779 GO:0015923 mannosidase activity 1/2202 16/18639 0.0625 0.529036103542234 0.866332953085056 0.999999999998779 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 1/2202 16/18639 0.0625 0.529036103542234 0.866332953085056 0.999999999998779 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity 1/2202 16/18639 0.0625 0.529036103542234 0.866332953085056 0.999999999998779 GO:0031435 mitogen-activated protein kinase kinase kinase binding 1/2202 16/18639 0.0625 0.529036103542234 0.866332953085056 0.999999999998779 GO:0070411 I-SMAD binding 1/2202 16/18639 0.0625 0.529036103542234 0.866332953085056 0.999999999998779 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 1/2202 16/18639 0.0625 0.529036103542234 0.866332953085056 0.999999999998779 GO:0004177 aminopeptidase activity 3/2202 40/18639 0.075 0.634843324250681 0.86701124686134 0.999999999998779 GO:0071949 FAD binding 3/2202 40/18639 0.075 0.634843324250681 0.86701124686134 0.999999999998779 GO:0016597 amino acid binding 4/2202 51/18639 0.0784313725490196 0.663888443660843 0.867695187069967 0.999999999998779 GO:0004629 phospholipase C activity 2/2202 29/18639 0.0689655172413793 0.583763976322465 0.872712814063846 0.999999999998779 GO:0035250 UDP-galactosyltransferase activity 2/2202 29/18639 0.0689655172413793 0.583763976322465 0.872712814063846 0.999999999998779 GO:0106222 lncRNA binding 2/2202 29/18639 0.0689655172413793 0.583763976322465 0.872712814063846 0.999999999998779 GO:0016757 glycosyltransferase activity 26/2202 267/18639 0.0973782771535581 0.824265989039586 0.877722099136999 0.999999999998779 GO:0140828 metal cation:monoatomic cation antiporter activity 3/2202 41/18639 0.0731707317073171 0.619359340732372 0.877835956689293 0.999999999998779 GO:1901682 sulfur compound transmembrane transporter activity 5/2202 63/18639 0.0793650793650794 0.671791877513948 0.879883314178544 0.999999999998779 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 1/2202 17/18639 0.0588235294117647 0.497916332745632 0.88213786299789 0.999999999998779 GO:0030169 low-density lipoprotein particle binding 1/2202 17/18639 0.0588235294117647 0.497916332745632 0.88213786299789 0.999999999998779 GO:0045125 bioactive lipid receptor activity 1/2202 17/18639 0.0588235294117647 0.497916332745632 0.88213786299789 0.999999999998779 GO:0045236 CXCR chemokine receptor binding 1/2202 17/18639 0.0588235294117647 0.497916332745632 0.88213786299789 0.999999999998779 GO:0048038 quinone binding 1/2202 17/18639 0.0588235294117647 0.497916332745632 0.88213786299789 0.999999999998779 GO:0051787 misfolded protein binding 1/2202 17/18639 0.0588235294117647 0.497916332745632 0.88213786299789 0.999999999998779 GO:0070492 oligosaccharide binding 1/2202 17/18639 0.0588235294117647 0.497916332745632 0.88213786299789 0.999999999998779 GO:0001968 fibronectin binding 2/2202 30/18639 0.0666666666666667 0.564305177111717 0.884689499297649 0.999999999998779 GO:0031210 phosphatidylcholine binding 2/2202 30/18639 0.0666666666666667 0.564305177111717 0.884689499297649 0.999999999998779 GO:0033612 receptor serine/threonine kinase binding 2/2202 30/18639 0.0666666666666667 0.564305177111717 0.884689499297649 0.999999999998779 GO:0005003 ephrin receptor activity 4/2202 53/18639 0.0754716981132075 0.638836049560434 0.886493298399075 0.999999999998779 GO:0005005 transmembrane-ephrin receptor activity 4/2202 53/18639 0.0754716981132075 0.638836049560434 0.886493298399075 0.999999999998779 GO:0004867 serine-type endopeptidase inhibitor activity 8/2202 95/18639 0.0842105263157895 0.712806539509537 0.886625024723916 0.999999999998779 GO:0031492 nucleosomal DNA binding 3/2202 42/18639 0.0714285714285714 0.604612689762554 0.887870246391265 0.999999999998779 GO:0042056 chemoattractant activity 3/2202 42/18639 0.0714285714285714 0.604612689762554 0.887870246391265 0.999999999998779 GO:0061135 endopeptidase regulator activity 17/2202 184/18639 0.0923913043478261 0.782053370453738 0.888400795916037 0.999999999998779 GO:0003725 double-stranded RNA binding 6/2202 75/18639 0.08 0.67716621253406 0.891245746917165 0.999999999998779 GO:0008013 beta-catenin binding 9/2202 106/18639 0.0849056603773585 0.718690555755488 0.892107547560909 0.999999999998779 GO:0002020 protease binding 12/2202 136/18639 0.0882352941176471 0.746874499118448 0.892217406573793 0.999999999998779 GO:0003925 G protein activity 4/2202 54/18639 0.0740740740740741 0.627005752346352 0.894986390010675 0.999999999998779 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 4/2202 54/18639 0.0740740740740741 0.627005752346352 0.894986390010675 0.999999999998779 GO:0047499 calcium-independent phospholipase A2 activity 2/2202 31/18639 0.0645161290322581 0.546101784301661 0.895614437064218 0.999999999998779 GO:0120013 lipid transfer activity 5/2202 65/18639 0.0769230769230769 0.651121358205827 0.895852359723052 0.999999999998779 GO:0008525 phosphatidylcholine transporter activity 1/2202 18/18639 0.0555555555555556 0.470254314259764 0.896074734745213 0.999999999998779 GO:0015172 acidic amino acid transmembrane transporter activity 1/2202 18/18639 0.0555555555555556 0.470254314259764 0.896074734745213 0.999999999998779 GO:0030228 lipoprotein particle receptor activity 1/2202 18/18639 0.0555555555555556 0.470254314259764 0.896074734745213 0.999999999998779 GO:0034185 apolipoprotein binding 1/2202 18/18639 0.0555555555555556 0.470254314259764 0.896074734745213 0.999999999998779 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 1/2202 18/18639 0.0555555555555556 0.470254314259764 0.896074734745213 0.999999999998779 GO:0070064 proline-rich region binding 1/2202 18/18639 0.0555555555555556 0.470254314259764 0.896074734745213 0.999999999998779 GO:0008375 acetylglucosaminyltransferase activity 3/2202 43/18639 0.0697674418604651 0.590551929535517 0.897160422046455 0.999999999998779 GO:0008378 galactosyltransferase activity 2/2202 32/18639 0.0625 0.529036103542234 0.905568843314378 0.999999999998779 GO:0015106 bicarbonate transmembrane transporter activity 2/2202 32/18639 0.0625 0.529036103542234 0.905568843314378 0.999999999998779 GO:0047498 calcium-dependent phospholipase A2 activity 2/2202 32/18639 0.0625 0.529036103542234 0.905568843314378 0.999999999998779 GO:0030020 extracellular matrix structural constituent conferring tensile strength 3/2202 44/18639 0.0681818181818182 0.577130294773347 0.90575161322759 0.999999999998779 GO:0005520 insulin-like growth factor binding 1/2202 19/18639 0.0526315789473684 0.44550408719346 0.90836426989859 0.999999999998779 GO:0022821 solute:potassium antiporter activity 1/2202 19/18639 0.0526315789473684 0.44550408719346 0.90836426989859 0.999999999998779 GO:0030506 ankyrin binding 1/2202 19/18639 0.0526315789473684 0.44550408719346 0.90836426989859 0.999999999998779 GO:0031420 alkali metal ion binding 1/2202 19/18639 0.0526315789473684 0.44550408719346 0.90836426989859 0.999999999998779 GO:0042834 peptidoglycan binding 1/2202 19/18639 0.0526315789473684 0.44550408719346 0.90836426989859 0.999999999998779 GO:0046624 sphingolipid transporter activity 1/2202 19/18639 0.0526315789473684 0.44550408719346 0.90836426989859 0.999999999998779 GO:0070003 threonine-type peptidase activity 1/2202 19/18639 0.0526315789473684 0.44550408719346 0.90836426989859 0.999999999998779 GO:0050840 extracellular matrix binding 5/2202 67/18639 0.0746268656716418 0.631684899751922 0.909949289555337 0.999999999998779 GO:0170055 lipid transmembrane transporter activity 4/2202 56/18639 0.0714285714285714 0.604612689762554 0.910310213485772 0.999999999998779 GO:0046915 transition metal ion transmembrane transporter activity 3/2202 45/18639 0.0666666666666667 0.564305177111717 0.913687555437682 0.999999999998779 GO:0042578 phosphoric ester hydrolase activity 35/2202 363/18639 0.0964187327823691 0.816143851194632 0.918871126016683 0.999999999998779 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 1/2202 20/18639 0.05 0.423228882833788 0.91920110543475 0.999999999998779 GO:0010851 cyclase regulator activity 1/2202 20/18639 0.05 0.423228882833788 0.91920110543475 0.999999999998779 GO:0015095 magnesium ion transmembrane transporter activity 1/2202 20/18639 0.05 0.423228882833788 0.91920110543475 0.999999999998779 GO:0016408 C-acyltransferase activity 1/2202 20/18639 0.05 0.423228882833788 0.91920110543475 0.999999999998779 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 1/2202 20/18639 0.05 0.423228882833788 0.91920110543475 0.999999999998779 GO:0042288 MHC class I protein binding 1/2202 20/18639 0.05 0.423228882833788 0.91920110543475 0.999999999998779 GO:0052745 inositol phosphate phosphatase activity 1/2202 20/18639 0.05 0.423228882833788 0.91920110543475 0.999999999998779 GO:0008028 monocarboxylic acid transmembrane transporter activity 5/2202 70/18639 0.0714285714285714 0.604612689762554 0.927956039253915 0.999999999998779 GO:0001618 virus receptor activity 6/2202 81/18639 0.0740740740740741 0.627005752346352 0.928000120558095 0.999999999998779 GO:0015101 organic cation transmembrane transporter activity 6/2202 81/18639 0.0740740740740741 0.627005752346352 0.928000120558095 0.999999999998779 GO:0008373 sialyltransferase activity 1/2202 21/18639 0.0476190476190476 0.403075126508369 0.928756890698872 0.999999999998779 GO:0009975 cyclase activity 1/2202 21/18639 0.0476190476190476 0.403075126508369 0.928756890698872 0.999999999998779 GO:0036122 BMP binding 1/2202 21/18639 0.0476190476190476 0.403075126508369 0.928756890698872 0.999999999998779 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 1/2202 21/18639 0.0476190476190476 0.403075126508369 0.928756890698872 0.999999999998779 GO:0051428 peptide hormone receptor binding 1/2202 21/18639 0.0476190476190476 0.403075126508369 0.928756890698872 0.999999999998779 GO:0061891 calcium ion sensor activity 1/2202 21/18639 0.0476190476190476 0.403075126508369 0.928756890698872 0.999999999998779 GO:0070182 DNA polymerase binding 1/2202 21/18639 0.0476190476190476 0.403075126508369 0.928756890698872 0.999999999998779 GO:0004623 phospholipase A2 activity 2/2202 35/18639 0.0571428571428571 0.483690151810043 0.930353174940486 0.999999999998779 GO:0140272 exogenous protein binding 6/2202 82/18639 0.0731707317073171 0.619359340732372 0.932926017051079 0.999999999998779 GO:0038187 pattern recognition receptor activity 3/2202 48/18639 0.0625 0.529036103542234 0.933977109107387 0.999999999998779 GO:0004714 transmembrane receptor protein tyrosine kinase activity 4/2202 60/18639 0.0666666666666667 0.564305177111717 0.935110444419547 0.999999999998779 GO:0004190 aspartic-type endopeptidase activity 2/2202 36/18639 0.0555555555555556 0.470254314259764 0.937146997698671 0.999999999998779 GO:0016409 palmitoyltransferase activity 2/2202 36/18639 0.0555555555555556 0.470254314259764 0.937146997698671 0.999999999998779 GO:0044390 ubiquitin-like protein conjugating enzyme binding 2/2202 36/18639 0.0555555555555556 0.470254314259764 0.937146997698671 0.999999999998779 GO:0005243 gap junction channel activity 1/2202 22/18639 0.0454545454545455 0.384753529848898 0.937183001273643 0.999999999998779 GO:0008970 phospholipase A1 activity 1/2202 22/18639 0.0454545454545455 0.384753529848898 0.937183001273643 0.999999999998779 GO:0061133 endopeptidase activator activity 1/2202 22/18639 0.0454545454545455 0.384753529848898 0.937183001273643 0.999999999998779 GO:0140517 protein-RNA adaptor activity 1/2202 22/18639 0.0454545454545455 0.384753529848898 0.937183001273643 0.999999999998779 GO:0140784 metal ion sensor activity 1/2202 22/18639 0.0454545454545455 0.384753529848898 0.937183001273643 0.999999999998779 GO:0016758 hexosyltransferase activity 17/2202 197/18639 0.0862944162436548 0.730445787631917 0.938847223852303 0.999999999998779 GO:0005004 GPI-linked ephrin receptor activity 3/2202 49/18639 0.0612244897959184 0.518239448367903 0.939696529748407 0.999999999998779 GO:0005008 hepatocyte growth factor receptor activity 3/2202 49/18639 0.0612244897959184 0.518239448367903 0.939696529748407 0.999999999998779 GO:0005009 insulin receptor activity 3/2202 49/18639 0.0612244897959184 0.518239448367903 0.939696529748407 0.999999999998779 GO:0005011 macrophage colony-stimulating factor receptor activity 3/2202 49/18639 0.0612244897959184 0.518239448367903 0.939696529748407 0.999999999998779 GO:0005018 platelet-derived growth factor alpha-receptor activity 3/2202 49/18639 0.0612244897959184 0.518239448367903 0.939696529748407 0.999999999998779 GO:0005020 stem cell factor receptor activity 3/2202 49/18639 0.0612244897959184 0.518239448367903 0.939696529748407 0.999999999998779 GO:0008288 boss receptor activity 3/2202 49/18639 0.0612244897959184 0.518239448367903 0.939696529748407 0.999999999998779 GO:0036332 placental growth factor receptor activity 3/2202 49/18639 0.0612244897959184 0.518239448367903 0.939696529748407 0.999999999998779 GO:0038062 protein tyrosine kinase collagen receptor activity 3/2202 49/18639 0.0612244897959184 0.518239448367903 0.939696529748407 0.999999999998779 GO:0060175 brain-derived neurotrophic factor receptor activity 3/2202 49/18639 0.0612244897959184 0.518239448367903 0.939696529748407 0.999999999998779 GO:0033218 amide binding 22/2202 247/18639 0.0890688259109312 0.75392999371201 0.940934669585195 0.999999999998779 GO:0030280 structural constituent of skin epidermis 2/2202 37/18639 0.0540540540540541 0.457544738198689 0.943308533379229 0.999999999998779 GO:0030551 cyclic nucleotide binding 2/2202 37/18639 0.0540540540540541 0.457544738198689 0.943308533379229 0.999999999998779 GO:0070001 aspartic-type peptidase activity 2/2202 37/18639 0.0540540540540541 0.457544738198689 0.943308533379229 0.999999999998779 GO:0005158 insulin receptor binding 1/2202 23/18639 0.0434782608695652 0.368025115507641 0.944612932583491 0.999999999998779 GO:0005212 structural constituent of eye lens 1/2202 23/18639 0.0434782608695652 0.368025115507641 0.944612932583491 0.999999999998779 GO:0031681 G-protein beta-subunit binding 1/2202 23/18639 0.0434782608695652 0.368025115507641 0.944612932583491 0.999999999998779 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 1/2202 23/18639 0.0434782608695652 0.368025115507641 0.944612932583491 0.999999999998779 GO:0005006 epidermal growth factor receptor activity 3/2202 50/18639 0.06 0.507874659400545 0.944953993910815 0.999999999998779 GO:0005007 fibroblast growth factor receptor activity 3/2202 50/18639 0.06 0.507874659400545 0.944953993910815 0.999999999998779 GO:0005017 platelet-derived growth factor receptor activity 3/2202 50/18639 0.06 0.507874659400545 0.944953993910815 0.999999999998779 GO:0005019 platelet-derived growth factor beta-receptor activity 3/2202 50/18639 0.06 0.507874659400545 0.944953993910815 0.999999999998779 GO:0005010 insulin-like growth factor receptor activity 3/2202 51/18639 0.0588235294117647 0.497916332745632 0.949782669338368 0.999999999998779 GO:0005021 vascular endothelial growth factor receptor activity 3/2202 51/18639 0.0588235294117647 0.497916332745632 0.949782669338368 0.999999999998779 GO:0005030 neurotrophin receptor activity 3/2202 51/18639 0.0588235294117647 0.497916332745632 0.949782669338368 0.999999999998779 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 1/2202 24/18639 0.0416666666666667 0.352690735694823 0.951164411013398 0.999999999998779 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 1/2202 24/18639 0.0416666666666667 0.352690735694823 0.951164411013398 0.999999999998779 GO:0004806 triacylglycerol lipase activity 1/2202 24/18639 0.0416666666666667 0.352690735694823 0.951164411013398 0.999999999998779 GO:0005540 hyaluronic acid binding 1/2202 24/18639 0.0416666666666667 0.352690735694823 0.951164411013398 0.999999999998779 GO:0050431 transforming growth factor beta binding 1/2202 24/18639 0.0416666666666667 0.352690735694823 0.951164411013398 0.999999999998779 GO:0008081 phosphoric diester hydrolase activity 6/2202 87/18639 0.0689655172413793 0.583763976322465 0.953334680903845 0.999999999998779 GO:0003707 nuclear steroid receptor activity 1/2202 25/18639 0.04 0.33858310626703 0.95694125586693 0.999999999998779 GO:0005251 delayed rectifier potassium channel activity 1/2202 25/18639 0.04 0.33858310626703 0.95694125586693 0.999999999998779 GO:0005537 D-mannose binding 1/2202 25/18639 0.04 0.33858310626703 0.95694125586693 0.999999999998779 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 1/2202 25/18639 0.04 0.33858310626703 0.95694125586693 0.999999999998779 GO:0120020 cholesterol transfer activity 1/2202 25/18639 0.04 0.33858310626703 0.95694125586693 0.999999999998779 GO:0008237 metallopeptidase activity 15/2202 184/18639 0.0815217391304348 0.690047091576827 0.957570586808147 0.999999999998779 GO:0005246 calcium channel regulator activity 3/2202 53/18639 0.0566037735849057 0.479127037170325 0.95827710953741 0.999999999998779 GO:0008146 sulfotransferase activity 3/2202 53/18639 0.0566037735849057 0.479127037170325 0.95827710953741 0.999999999998779 GO:0038064 collagen receptor activity 3/2202 53/18639 0.0566037735849057 0.479127037170325 0.95827710953741 0.999999999998779 GO:0015144 carbohydrate transmembrane transporter activity 2/2202 40/18639 0.05 0.423228882833788 0.95852432781139 0.999999999998779 GO:0071855 neuropeptide receptor binding 2/2202 40/18639 0.05 0.423228882833788 0.95852432781139 0.999999999998779 GO:0015485 cholesterol binding 3/2202 54/18639 0.0555555555555556 0.470254314259764 0.962000093038983 0.999999999998779 GO:0004112 cyclic-nucleotide phosphodiesterase activity 1/2202 26/18639 0.0384615384615385 0.325560679102913 0.9620350215584 0.999999999998779 GO:0004529 DNA exonuclease activity 1/2202 26/18639 0.0384615384615385 0.325560679102913 0.9620350215584 0.999999999998779 GO:0005227 calcium-activated cation channel activity 1/2202 26/18639 0.0384615384615385 0.325560679102913 0.9620350215584 0.999999999998779 GO:0019865 immunoglobulin binding 1/2202 26/18639 0.0384615384615385 0.325560679102913 0.9620350215584 0.999999999998779 GO:0043548 phosphatidylinositol 3-kinase binding 1/2202 26/18639 0.0384615384615385 0.325560679102913 0.9620350215584 0.999999999998779 GO:0015175 neutral L-amino acid transmembrane transporter activity 2/2202 41/18639 0.0487804878048781 0.412906227154915 0.962662192997138 0.999999999998779 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 6/2202 91/18639 0.0659340659340659 0.55810402131928 0.965421553197606 0.999999999998779 GO:0005044 scavenger receptor activity 1/2202 27/18639 0.037037037037037 0.313502876173176 0.966526445967598 0.999999999998779 GO:0005385 zinc ion transmembrane transporter activity 1/2202 27/18639 0.037037037037037 0.313502876173176 0.966526445967598 0.999999999998779 GO:0008395 steroid hydroxylase activity 1/2202 27/18639 0.037037037037037 0.313502876173176 0.966526445967598 0.999999999998779 GO:0023026 MHC class II protein complex binding 1/2202 27/18639 0.037037037037037 0.313502876173176 0.966526445967598 0.999999999998779 GO:0016417 S-acyltransferase activity 1/2202 29/18639 0.0344827586206897 0.291881988161233 0.973978653319218 0.999999999998779 GO:0051861 glycolipid binding 1/2202 29/18639 0.0344827586206897 0.291881988161233 0.973978653319218 0.999999999998779 GO:0001540 amyloid-beta binding 5/2202 83/18639 0.0602409638554217 0.509914316667214 0.974198745449038 0.999999999998779 GO:0030165 PDZ domain binding 5/2202 83/18639 0.0602409638554217 0.509914316667214 0.974198745449038 0.999999999998779 GO:0016298 lipase activity 9/2202 130/18639 0.0692307692307692 0.586009222385244 0.976276481683484 0.999999999998779 GO:0001965 G-protein alpha-subunit binding 1/2202 30/18639 0.0333333333333333 0.282152588555858 0.977057589664789 0.999999999998779 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 1/2202 30/18639 0.0333333333333333 0.282152588555858 0.977057589664789 0.999999999998779 GO:0022839 monoatomic ion-gated channel activity 1/2202 30/18639 0.0333333333333333 0.282152588555858 0.977057589664789 0.999999999998779 GO:0031624 ubiquitin conjugating enzyme binding 1/2202 30/18639 0.0333333333333333 0.282152588555858 0.977057589664789 0.999999999998779 GO:0004620 phospholipase activity 7/2202 109/18639 0.0642201834862385 0.543596730245232 0.978843155071266 0.999999999998779 GO:0005184 neuropeptide hormone activity 1/2202 31/18639 0.032258064516129 0.273050892150831 0.979772361418142 0.999999999998779 GO:0017147 Wnt-protein binding 1/2202 31/18639 0.032258064516129 0.273050892150831 0.979772361418142 0.999999999998779 GO:0072349 modified amino acid transmembrane transporter activity 1/2202 31/18639 0.032258064516129 0.273050892150831 0.979772361418142 0.999999999998779 GO:0030246 carbohydrate binding 23/2202 280/18639 0.0821428571428571 0.695304593226937 0.979993050452627 0.999999999998779 GO:0008194 UDP-glycosyltransferase activity 10/2202 145/18639 0.0689655172413793 0.583763976322465 0.981815322607431 0.999999999998779 GO:0120015 sterol transfer activity 1/2202 32/18639 0.03125 0.264518051771117 0.982166023292456 0.999999999998779 GO:0160041 neuropeptide activity 1/2202 32/18639 0.03125 0.264518051771117 0.982166023292456 0.999999999998779 GO:0015179 L-amino acid transmembrane transporter activity 3/2202 62/18639 0.0483870967741935 0.409576338226246 0.982320482520498 0.999999999998779 GO:0019838 growth factor binding 9/2202 136/18639 0.0661764705882353 0.560155874338836 0.984381479439524 0.999999999998779 GO:0044325 transmembrane transporter binding 9/2202 136/18639 0.0661764705882353 0.560155874338836 0.984381479439524 0.999999999998779 GO:0015020 glucuronosyltransferase activity 1/2202 34/18639 0.0294117647058824 0.248958166372816 0.986137396037013 0.999999999998779 GO:0015035 protein-disulfide reductase activity 1/2202 34/18639 0.0294117647058824 0.248958166372816 0.986137396037013 0.999999999998779 GO:0019825 oxygen binding 1/2202 34/18639 0.0294117647058824 0.248958166372816 0.986137396037013 0.999999999998779 GO:0051427 hormone receptor binding 1/2202 34/18639 0.0294117647058824 0.248958166372816 0.986137396037013 0.999999999998779 GO:0090482 vitamin transmembrane transporter activity 1/2202 34/18639 0.0294117647058824 0.248958166372816 0.986137396037013 0.999999999998779 GO:0019199 transmembrane receptor protein kinase activity 4/2202 78/18639 0.0512820512820513 0.434080905470551 0.986459872686679 0.999999999998779 GO:0046982 protein heterodimerization activity 31/2202 369/18639 0.0840108401084011 0.711116280100131 0.98666928841686 0.999999999998779 GO:0005272 sodium channel activity 2/2202 51/18639 0.0392156862745098 0.331944221830421 0.987222328342918 0.999999999998779 GO:0008514 organic anion transmembrane transporter activity 21/2202 269/18639 0.0780669144981413 0.660803460186583 0.98777051673381 0.999999999998779 GO:0043178 alcohol binding 5/2202 92/18639 0.0543478260869565 0.460031394384552 0.987921622847833 0.999999999998779 GO:0046906 tetrapyrrole binding 10/2202 152/18639 0.0657894736842105 0.556880108991826 0.988769035880296 0.999999999998779 GO:0016500 protein-hormone receptor activity 3/2202 67/18639 0.0447761194029851 0.379010939851153 0.989191083137777 0.999999999998779 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 1/2202 36/18639 0.0277777777777778 0.235127157129882 0.989224711585735 0.999999999998779 GO:0020037 heme binding 9/2202 142/18639 0.0633802816901408 0.536487316268181 0.98985519638102 0.999999999998779 GO:0005548 phospholipid transporter activity 3/2202 68/18639 0.0441176470588235 0.373437249559224 0.990215060854177 0.999999999998779 GO:0032934 sterol binding 3/2202 68/18639 0.0441176470588235 0.373437249559224 0.990215060854177 0.999999999998779 GO:0023023 MHC protein complex binding 1/2202 37/18639 0.027027027027027 0.228772369099345 0.99050016098036 0.999999999998779 GO:0043394 proteoglycan binding 1/2202 37/18639 0.027027027027027 0.228772369099345 0.99050016098036 0.999999999998779 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 2/2202 54/18639 0.037037037037037 0.313502876173176 0.990796068681164 0.999999999998779 GO:0005496 steroid binding 6/2202 108/18639 0.0555555555555556 0.470254314259764 0.991082896769039 0.999999999998779 GO:0005109 frizzled binding 1/2202 38/18639 0.0263157894736842 0.22275204359673 0.991624698423713 0.999999999998779 GO:0042887 amide transmembrane transporter activity 1/2202 38/18639 0.0263157894736842 0.22275204359673 0.991624698423713 0.999999999998779 GO:0042626 ATPase-coupled transmembrane transporter activity 5/2202 98/18639 0.0510204081632653 0.431866206973253 0.992849065755384 0.999999999998779 GO:0015036 disulfide oxidoreductase activity 1/2202 40/18639 0.025 0.211614441416894 0.993490322627263 0.999999999998779 GO:0001530 lipopolysaccharide binding 1/2202 41/18639 0.024390243902439 0.206453113577457 0.994261025868016 0.999999999998779 GO:0042287 MHC protein binding 1/2202 41/18639 0.024390243902439 0.206453113577457 0.994261025868016 0.999999999998779 GO:0003730 mRNA 3'-UTR binding 19/2202 262/18639 0.0725190839694656 0.613843417850531 0.994500831724825 0.999999999998779 GO:0070851 growth factor receptor binding 8/2202 139/18639 0.0575539568345324 0.487169937074863 0.994787484991979 0.999999999998779 GO:0046943 carboxylic acid transmembrane transporter activity 12/2202 188/18639 0.0638297872340425 0.540292190851644 0.995560134013695 0.999999999998779 GO:0005342 organic acid transmembrane transporter activity 12/2202 189/18639 0.0634920634920635 0.537433502011159 0.995861371962888 0.999999999998779 GO:0005506 iron ion binding 9/2202 154/18639 0.0584415584415584 0.494683109805726 0.995874542070136 0.999999999998779 GO:0030547 signaling receptor inhibitor activity 1/2202 44/18639 0.0227272727272727 0.192376764924449 0.996067761448861 0.999999999998779 GO:0008009 chemokine activity 1/2202 45/18639 0.0222222222222222 0.188101725703906 0.996533412929883 0.999999999998779 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 1/2202 46/18639 0.0217391304347826 0.184012557753821 0.99694394453838 0.999999999998779 GO:0140359 ABC-type transporter activity 1/2202 47/18639 0.0212765957446809 0.180097396950548 0.997305878283687 0.999999999998779 GO:0008201 heparin binding 10/2202 172/18639 0.0581395348837209 0.492126607946265 0.997406221864448 0.999999999998779 GO:0004222 metalloendopeptidase activity 5/2202 110/18639 0.0454545454545455 0.384753529848898 0.997584823412182 0.999999999998779 GO:0008188 neuropeptide receptor activity 1/2202 48/18639 0.0208333333333333 0.176345367847411 0.997624964773539 0.999999999998779 GO:0015291 secondary active transmembrane transporter activity 20/2202 287/18639 0.0696864111498258 0.589866038792735 0.997668420773711 0.999999999998779 GO:0015103 inorganic anion transmembrane transporter activity 9/2202 165/18639 0.0545454545454545 0.461704235818677 0.998260190857299 0.999999999998779 GO:0098960 postsynaptic neurotransmitter receptor activity 2/2202 69/18639 0.0289855072463768 0.245350077005094 0.998272833372345 0.999999999998779 GO:0015171 amino acid transmembrane transporter activity 4/2202 102/18639 0.0392156862745098 0.331944221830421 0.998627793788829 0.999999999998779 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 10/2202 181/18639 0.0552486187845304 0.467656224125732 0.998708478554368 0.999999999998779 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 1/2202 53/18639 0.0188679245283019 0.159709012390108 0.998735592145198 0.999999999998779 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 1/2202 56/18639 0.0178571428571429 0.151153172440638 0.999133876579735 0.999999999998779 GO:0042277 peptide binding 15/2202 249/18639 0.0602409638554217 0.509914316667214 0.999313907070394 0.999999999998779 GO:0005319 lipid transporter activity 9/2202 178/18639 0.050561797752809 0.427984263539785 0.999398534251169 0.999999999998779 GO:0015026 coreceptor activity 1/2202 61/18639 0.0163934426229508 0.138763568142225 0.999539031469031 0.999999999998779 GO:0022824 transmitter-gated monoatomic ion channel activity 1/2202 63/18639 0.0158730158730159 0.13435837550279 0.99964183274622 0.999999999998779 GO:0022835 transmitter-gated channel activity 1/2202 63/18639 0.0158730158730159 0.13435837550279 0.99964183274622 0.999999999998779 GO:0005262 calcium channel activity 5/2202 131/18639 0.0381679389312977 0.323075483079227 0.999671941055308 0.999999999998779 GO:0005179 hormone activity 5/2202 132/18639 0.0378787878787879 0.320627941540748 0.999702460824593 0.999999999998779 GO:0038024 cargo receptor activity 1/2202 65/18639 0.0153846153846154 0.130224271641165 0.999721716216026 0.999999999998779 GO:0005178 integrin binding 7/2202 161/18639 0.0434782608695652 0.368025115507641 0.999729954942816 0.999999999998779 GO:0005253 monoatomic anion channel activity 3/2202 103/18639 0.029126213592233 0.246541096796381 0.999747491784985 0.999999999998779 GO:0008083 growth factor activity 7/2202 162/18639 0.0432098765432099 0.365753355535372 0.999753435318234 0.999999999998779 GO:0005539 glycosaminoglycan binding 13/2202 242/18639 0.0537190082644628 0.454708717094152 0.999807637155412 0.999999999998779 GO:0005267 potassium channel activity 4/2202 124/18639 0.032258064516129 0.273050892150831 0.999852586649647 0.999999999998779 GO:0005201 extracellular matrix structural constituent 7/2202 168/18639 0.0416666666666667 0.352690735694823 0.999857771331328 0.999999999998779 GO:0042379 chemokine receptor binding 1/2202 72/18639 0.0138888888888889 0.117563578564941 0.999884974029571 0.999999999998779 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 1/2202 73/18639 0.0136986301369863 0.115953118584599 0.999898615823446 0.999999999998779 GO:0005126 cytokine receptor binding 15/2202 275/18639 0.0545454545454545 0.461704235818677 0.999900882006905 0.999999999998779 GO:0019955 cytokine binding 5/2202 144/18639 0.0347222222222222 0.293908946412352 0.999909247740718 0.999999999998779 GO:0030594 neurotransmitter receptor activity 2/2202 97/18639 0.0206185567010309 0.174527374364448 0.999931208611554 0.999999999998779 GO:0015085 calcium ion transmembrane transporter activity 5/2202 147/18639 0.0340136054421769 0.287910804648835 0.999932840740534 0.999999999998779 GO:0005249 voltage-gated potassium channel activity 2/2202 98/18639 0.0204081632653061 0.172746482789301 0.999938794064287 0.999999999998779 GO:0008509 monoatomic anion transmembrane transporter activity 5/2202 149/18639 0.0335570469798658 0.28404623008979 0.999945101605066 0.999999999998779 GO:0099094 ligand-gated monoatomic cation channel activity 4/2202 136/18639 0.0294117647058824 0.248958166372816 0.999958001623808 0.999999999998779 GO:0015108 chloride transmembrane transporter activity 3/2202 121/18639 0.0247933884297521 0.209865561735762 0.999964908075697 0.999999999998779 GO:0017171 serine hydrolase activity 8/2202 198/18639 0.0404040404040404 0.342003137643465 0.999967988372663 0.999999999998779 GO:0005254 chloride channel activity 1/2202 83/18639 0.0120481927710843 0.101982863333443 0.999971322603105 0.999999999998779 GO:0004497 monooxygenase activity 2/2202 106/18639 0.0188679245283019 0.159709012390108 0.999976044296719 0.999999999998779 GO:0015079 potassium ion transmembrane transporter activity 5/2202 160/18639 0.03125 0.264518051771117 0.999982095056343 0.999999999998779 GO:0001664 G protein-coupled receptor binding 15/2202 297/18639 0.0505050505050505 0.427503922054331 0.999982498920444 0.999999999998779 GO:0008236 serine-type peptidase activity 7/2202 194/18639 0.0360824742268041 0.305422905137785 0.999987873527924 0.999999999998779 GO:0004175 endopeptidase activity 23/2202 405/18639 0.0567901234567901 0.480704410132203 0.999992124715706 0.999999999998779 GO:0015294 solute:monoatomic cation symporter activity 2/2202 116/18639 0.0172413793103448 0.145940994080616 0.999992639893508 0.999999999998779 GO:0004896 cytokine receptor activity 1/2202 96/18639 0.0104166666666667 0.0881726839237057 0.999994452350812 0.999999999998779 GO:0005125 cytokine activity 9/2202 234/18639 0.0384615384615385 0.325560679102913 0.999995855861433 0.999999999998779 GO:0005261 monoatomic cation channel activity 17/2202 341/18639 0.0498533724340176 0.42198774241492 0.9999961699496 0.999999999998779 GO:0008528 G protein-coupled peptide receptor activity 2/2202 122/18639 0.0163934426229508 0.138763568142225 0.999996387424766 0.999999999998779 GO:0015293 symporter activity 3/2202 146/18639 0.0205479452054795 0.173929677876899 0.999997883703014 0.999999999998779 GO:0001653 peptide receptor activity 2/2202 128/18639 0.015625 0.132259025885559 0.999998231104938 0.999999999998779 GO:0004252 serine-type endopeptidase activity 4/2202 176/18639 0.0227272727272727 0.192376764924449 0.999999445881342 0.999999999998779 GO:0022843 voltage-gated monoatomic cation channel activity 2/2202 143/18639 0.013986013986014 0.118385701491969 0.999999706006354 0.999999999998779 GO:0015081 sodium ion transmembrane transporter activity 3/2202 164/18639 0.0182926829268293 0.154839835183093 0.99999972999435 0.999999999998779 GO:0015276 ligand-gated monoatomic ion channel activity 4/2202 186/18639 0.021505376344086 0.182033928100554 0.999999817203779 0.999999999998779 GO:0022834 ligand-gated channel activity 4/2202 188/18639 0.0212765957446809 0.180097396950548 0.999999853724216 0.999999999998779 GO:0005216 monoatomic ion channel activity 20/2202 448/18639 0.0446428571428571 0.377882931101596 0.999999987144161 0.999999999998779 GO:0005244 voltage-gated monoatomic ion channel activity 2/2202 173/18639 0.0115606936416185 0.0978563890945173 0.999999992143863 0.999999999998779 GO:0022832 voltage-gated channel activity 2/2202 175/18639 0.0114285714285714 0.0967380303620086 0.99999999383753 0.999999999998779 GO:0140375 immune receptor activity 1/2202 156/18639 0.00641025641025641 0.0542601131838189 0.999999997217547 0.999999999998779 GO:0045182 translation regulator activity 11/2202 356/18639 0.0308988764044944 0.261545938829869 0.999999999479279 0.999999999998779 GO:0022836 gated channel activity 6/2202 318/18639 0.0188679245283019 0.159709012390108 0.999999999995786 0.999999999998779 GO:0046873 metal ion transmembrane transporter activity 14/2202 450/18639 0.0311111111111111 0.263342415985468 0.999999999995792 0.999999999998779 GO:0030371 translation repressor activity 6/2202 329/18639 0.0182370820668693 0.154369197386184 0.999999999998779 0.999999999998779