category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	10/88	82/9376	12.9933481152993	HSPA1B/HSPA1A/HLA-DRB1/HLA-B/HSP90AA1/HLA-DPB1/HSPA2/HSP90AB1/HLA-DRA/B2M	10.6172465520738
Genetic Information Processing	Translation	hsa03010	Ribosome	14/88	222/9376	6.71908271908272	RPS6/RPL5/RPL36A/MRPL43/RPL6/RPL26/MRPL16/RPL19/RPS25/MRPL40/RPL32/RPS12/RPL34/RPS23	8.39389016625956
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	14/88	275/9376	5.42413223140496	HSPA1B/HSPA1A/MT-ATP8/UQCR11/RAC1/ATP5PF/COX6A1/COX6B1/CAV2/TUBB2A/COX7C/NDUFB8/COX5B/MT-ND5	7.24795952804137
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	12/88	227/9376	5.63235883059672	MT-ATP8/UQCR11/RAC1/ATP5PF/COX6A1/COX6B1/GSTO1/ACP1/COX7C/NDUFB8/COX5B/MT-ND5	6.87692327407192
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	12/88	238/9376	5.3720397249809	PLCG2/RPS6/RPL5/RPL36A/RPL6/RPL26/RPL19/RPS25/RPL32/RPS12/RPL34/RPS23	6.64986566188142
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	11/88	205/9376	5.71707317073171	MT-ATP8/UQCR11/RAC1/ATP5PF/COX6A1/COX6B1/GAPDH/COX7C/NDUFB8/COX5B/MT-ND5	6.64671515898659
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	9/88	138/9376	6.94861660079051	MT-ATP8/UQCR11/ATP5PF/COX6A1/COX6B1/COX7C/NDUFB8/COX5B/MT-ND5	6.85223760438988
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	10/88	235/9376	4.53384912959381	MT-ATP8/UQCR11/RPS6/ATP5PF/COX6A1/COX6B1/COX7C/NDUFB8/COX5B/MT-ND5	5.34011920674962
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	10/88	248/9376	4.29618768328446	S100A10/RAC1/TNFSF10/MYL12B/DYNLRB1/GAPDH/HSP90AA1/TUBB2A/MYL12A/HSP90AB1	5.12054076404209
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	8/88	160/9376	5.32727272727273	CDH2/HLA-DRB1/HLA-B/ESAM/ICAM2/HLA-DPB1/CLDN5/HLA-DRA	5.37364406685557
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	11/88	308/9376	3.8051948051948	MT-ATP8/UQCR11/ATP5PF/COX6A1/COX6B1/POLR2I/TUBB2A/COX7C/NDUFB8/COX5B/MT-ND5	4.87246243352807
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	12/88	368/9376	3.47430830039526	MT-ATP8/UQCR11/RAC1/ATP5PF/MAP1LC3A/COX6A1/COX6B1/TUBB2A/COX7C/NDUFB8/COX5B/MT-ND5	4.71334688624369
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	10/88	268/9376	3.97557666214383	MT-ATP8/UQCR11/ATP5PF/COX6A1/COX6B1/TUBB2A/COX7C/NDUFB8/COX5B/MT-ND5	4.8105297051338
Human Diseases	Immune disease	hsa05330	Allograft rejection	4/88	39/9376	10.9277389277389	HLA-DRB1/HLA-B/HLA-DPB1/HLA-DRA	6.04706786886436
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	5/88	70/9376	7.61038961038961	HLA-DRB1/HLA-B/RAC1/HLA-DPB1/HLA-DRA	5.40331670951378
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	8/88	205/9376	4.15787139689579	HLA-DRB1/HLA-B/PLCG2/RAC1/HES1/HLA-DPB1/HLA-DRA/B2M	4.44968117393471
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	7/88	157/9376	4.7504342790967	UQCR11/RAC1/COX6A1/COX6B1/COX7C/NDUFB8/COX5B	4.61270147800354
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	4/88	44/9376	9.68595041322314	HLA-DRB1/HLA-B/HLA-DPB1/HLA-DRA	5.62111136783064
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	6/88	116/9376	5.51097178683386	PLCG2/RAC1/ESAM/MYL12B/MYL12A/CLDN5	4.75838396194184
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	4/88	45/9376	9.47070707070707	HLA-DRB1/HLA-B/HLA-DPB1/HLA-DRA	5.54405712540511
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	11/88	388/9376	3.02061855670103	MT-ATP8/UQCR11/ATP5PF/COX6A1/COX6B1/GAPDH/TUBB2A/COX7C/NDUFB8/COX5B/MT-ND5	3.95671290019998
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	5/88	87/9376	6.12330198537095	UQCR11/COX6A1/COX6B1/COX7C/COX5B	4.67294824719975
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	4/88	54/9376	7.89225589225589	HLA-DRB1/HLA-B/HLA-DPB1/HLA-DRA	4.94389905685385
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	12/88	480/9376	2.66363636363636	MT-ATP8/UQCR11/RAC1/ATP5PF/MAP1LC3A/COX6A1/COX6B1/TUBB2A/COX7C/NDUFB8/COX5B/MT-ND5	3.64206344571833
Human Diseases	Immune disease	hsa05310	Asthma	3/88	32/9376	9.98863636363636	HLA-DRB1/HLA-DPB1/HLA-DRA	4.95756316744481
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	6/88	155/9376	4.12434017595308	HLA-DRB1/HLA-B/RAC1/HLA-DPB1/TUBB2A/HLA-DRA	3.81769318278829
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	5/88	109/9376	4.88740617180984	HLA-DRB1/HSP90AA1/HLA-DPB1/HSP90AB1/HLA-DRA	3.97346560647815
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	7/88	214/9376	3.48513169073917	HLA-B/PLCG2/GNG5/GNG11/RAC1/RNF7/B2M	3.57953836460185
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	5/88	112/9376	4.75649350649351	HSPA1B/HSPA1A/HLA-DRB1/HLA-DPB1/HLA-DRA	3.89276557956179
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	7/88	216/9376	3.45286195286195	HSPA1B/HSPA1A/RAC1/TNFSF10/HSP90AA1/HSPA2/HSP90AB1	3.54991632508199
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	6/88	174/9376	3.67398119122257	HSPA1B/HSPA1A/HSP90AA1/HSPH1/HSP90AB1/KRTCAP2	3.46543477141353
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	4/88	78/9376	5.46386946386946	HLA-DRB1/HLA-DPB1/MARCKSL1/HLA-DRA	3.85327395893222
NA	NA	hsa04517	IgSF CAM signaling	8/88	299/9376	2.85071450288842	CDH2/PLCG2/RAC1/ESAM/ICAM2/MYL12B/TUBB2A/MYL12A	3.16569977690754
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	5/88	133/9376	4.00546821599453	HLA-B/PLCG2/RAC1/TNFSF10/ICAM2	3.39779641954649
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	6/88	196/9376	3.26159554730983	HLA-B/PLCG2/GNG5/GNG11/RAC1/MAP1LC3A	3.11449405641143
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	5/88	142/9376	3.75160051216389	RAC1/GSTO1/HSP90AA1/CAV2/HSP90AB1	3.21588484907414
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	6/88	200/9376	3.19636363636364	NCL/RAC1/TNFSF10/GAPDH/TUBB2A/CLDN5	3.05603561422927
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	4/88	93/9376	4.58260019550342	RAC1/MYL12B/ACP1/MYL12A	3.37957053650114
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	3/88	50/9376	6.39272727272727	HLA-DRB1/HLA-DPB1/HLA-DRA	3.72144517025312
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	3/88	60/9376	5.32727272727273	PLCG2/HSPB1/RAC1	3.27296245726371
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	5/88	170/9376	3.13368983957219	RAB13/RAC1/MYL12B/MYL12A/CLDN5	2.73266337087405
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	3/88	66/9376	4.84297520661157	HLA-DRB1/HLA-DPB1/HLA-DRA	3.04951364374798
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	2/88	26/9376	8.1958041958042	HES1/HHEX	3.5762352266522
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	5/88	180/9376	2.95959595959596	HLA-DRB1/HLA-B/HLA-DPB1/HLA-DRA/B2M	2.58386118215711
Cellular Processes	Cell motility	hsa04814	Motor proteins	5/88	194/9376	2.74601686972821	MYL12B/DYNLRB1/KIF9/TUBB2A/MYL12A	2.3919193223295
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	4/88	139/9376	3.06605624591236	HSPA1B/HSPA1A/HSP90AA1/HSP90AB1	2.38863581460111
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	4/88	140/9376	3.04415584415584	GNG5/RPS6/GNG11/MAP1LC3A	2.3719303354569
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	4/88	149/9376	2.86028065893838	GNG5/GNG11/NDUFB8/MT-ND5	2.22795910840381
NA	NA	hsa04382	Cornified envelope formation	5/88	217/9376	2.45496439044826	S100A16/S100A10/S100A13/S100A11/CLDN5	2.11068815355872
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	7/88	362/9376	2.06027122049221	GNG5/RPS6/GNG11/RAC1/HSP90AA1/HSP90AB1/YWHAB	2.00252687188976
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	3/88	93/9376	3.43695014662757	HLA-DRB1/HLA-DPB1/HLA-DRA	2.29884566098154
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	2/88	42/9376	5.07359307359307	MAP1LC3A/SAT1	2.57533815009697
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	5/88	224/9376	2.37824675324675	HLA-DRB1/HLA-B/HLA-DPB1/HLA-DRA/B2M	2.03216446281366
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	3/88	95/9376	3.36459330143541	HLA-DRB1/HLA-DPB1/HLA-DRA	2.25468949910076
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	5/88	227/9376	2.3468161794153	HLA-B/GNG5/GNG11/RAC1/B2M	1.99940286770155
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	3/88	98/9376	3.26159554730983	PLCG2/RAC1/MARCKSL1	2.19061806664001
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	3/88	99/9376	3.22865013774105	HLA-DRB1/HLA-DPB1/HLA-DRA	2.16980940089071
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	3/88	100/9376	3.19636363636364	HLA-DRB1/HLA-DPB1/HLA-DRA	2.14926390778094
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	4/88	173/9376	2.46347871781398	HLA-DRB1/TNFSF10/HLA-DPB1/HLA-DRA	1.89108313999798
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	3/88	110/9376	2.90578512396694	PLCG2/RPS6/GAPDH	1.95699627133485
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	5/88	250/9376	2.13090909090909	HSPA1B/HSPA1A/HLA-B/VPS28/CAV2	1.76410056160033
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	5/88	253/9376	2.10564139417894	PLCG2/RAC1/MAP1LC3A/MYL12B/MYL12A	1.73528808172704
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	4/88	184/9376	2.31620553359684	PLCG2/RAC1/MYL12B/MYL12A	1.75506613727135
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	2/88	56/9376	3.8051948051948	HSPA1B/HSPA1A	2.04934442296085
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	4/88	187/9376	2.2790471560525	MAP1LC3A/HSP90AA1/HSP90AB1/CARD16	1.71964620179094
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	4/88	193/9376	2.20819594912859	PLCG2/GNG5/GNG11/RAC1	1.65078155838982
Organismal Systems	Immune system	hsa04611	Platelet activation	3/88	126/9376	2.53679653679654	PLCG2/MYL12B/MYL12A	1.69042789322633
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	2/88	62/9376	3.43695014662757	HSPA1B/HSPA1A	1.87387338836048
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	4/88	203/9376	2.09941782355575	RAC1/MYL12B/CAV2/MYL12A	1.54141991773312
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	4/88	204/9376	2.0891265597148	PLCG2/RPS6/RAC1/CAV2	1.53083111379901
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	2/88	67/9376	3.18046132971506	GAPDH/TPI1	1.74341246197168
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/88	15/9376	7.1030303030303	ACP1	2.3024801997489
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	2/88	69/9376	3.08827404479578	PLCG2/RAC1	1.694622818466
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/88	16/9376	6.65909090909091	MIF	2.20513208566376
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	2/88	71/9376	3.00128040973111	PLCG2/RAC1	1.64757351002441
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	3/88	143/9376	2.23521932612842	HLA-DRB1/HLA-DPB1/HLA-DRA	1.44879370344961
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	2/88	75/9376	2.84121212121212	GAPDH/TPI1	1.55824415216477
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/88	19/9376	5.60765550239234	HYAL2	1.95683567630628
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	2/88	78/9376	2.73193473193473	PLCG2/TPI1	1.49503005299564
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	2/88	78/9376	2.73193473193473	RAC1/CAV2	1.49503005299564
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	2/88	80/9376	2.66363636363636	PLCG2/RPS6	1.45452507122389
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	2/88	82/9376	2.59866962305987	NME1/GSTO1	1.41524029655116
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	4/88	238/9376	1.79067990832697	PLCG2/GNG5/GNG11/RAC1	1.20262291805823
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	2/88	85/9376	2.50695187165775	NME1/APRT	1.35844946150655
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	2/88	89/9376	2.39427987742594	GNG5/GNG11	1.28639134975269
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	3/88	168/9376	1.9025974025974	TNFSF10/HSP90AA1/HSP90AB1	1.14903150293341
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	2/88	91/9376	2.34165834165834	PLCG2/RAC1	1.25180749709536
Human Diseases	Substance dependence	hsa05032	Morphine addiction	2/88	91/9376	2.34165834165834	GNG5/GNG11	1.25180749709536
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	2/88	94/9376	2.26692456479691	HSP90AA1/HSP90AB1	1.20159959302185
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	2/88	97/9376	2.19681349578257	GNG5/GNG11	1.15326106066579
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	3/88	181/9376	1.7659467604219	HLA-DRB1/HLA-DPB1/HLA-DRA	1.01280975397211
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	2/88	101/9376	2.10981098109811	PLCG2/RAC1	1.09148712274365
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/88	31/9376	3.43695014662757	SEC11C	1.32282900762055
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	2/88	105/9376	2.02943722943723	MAP1LC3A/FIS1	1.03251673709142
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	2/88	106/9376	2.01029159519726	HSP90AA1/HSP90AB1	1.01818261291788
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/88	34/9376	3.13368983957219	POLR2I	1.21315610230424
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	2/88	110/9376	1.93719008264463	HSP90AA1/HSP90AB1	0.962373708453477
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/88	35/9376	3.04415584415584	TPI1	1.17928075137915
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	2/88	115/9376	1.85296442687747	GNG5/GNG11	0.895811777940706
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	2/88	115/9376	1.85296442687747	GNG5/GNG11	0.895811777940706
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/88	37/9376	2.87960687960688	MIF	1.11502234617157
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	2/88	116/9376	1.83699059561129	GAPDH/TPI1	0.882896815732087
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	2/88	116/9376	1.83699059561129	GNG5/GNG11	0.882896815732087
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	2/88	117/9376	1.82128982128982	ZNHIT1/TFPT	0.870108077026714
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	3/88	205/9376	1.55920177383592	HLA-B/RAC1/YWHAB	0.78795786551491
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	4/88	300/9376	1.42060606060606	HSPA1B/HSPA1A/HSPB1/RAC1	0.72070042954576
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	2/88	120/9376	1.77575757575758	PLCG2/RAC1	0.832474321992117
NA	NA	hsa04519	Cadherin signaling	5/88	404/9376	1.31863186318632	CDH2/CDH12/RAC1/TMC5/YWHAB	0.637237205008822
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	3/88	217/9376	1.47297863426896	GSTO1/HSP90AA1/HSP90AB1	0.686140778971435
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	2/88	128/9376	1.66477272727273	NME1/APRT	0.737089354893243
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	1/88	44/9376	2.42148760330579	KRTCAP2	0.919915466476565
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	2/88	130/9376	1.63916083916084	GNG5/GNG11	0.714283734820358
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	2/88	133/9376	1.60218728639781	GNG5/GNG11	0.680795689247319
NA	NA	hsa03272	Virion - Hepatitis viruses	1/88	48/9376	2.21969696969697	CLDN5	0.824601585901752
Human Diseases	Infectious disease: viral	hsa05162	Measles	2/88	136/9376	1.5668449197861	HSPA1B/HSPA1A	0.648132199915133
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	3/88	232/9376	1.37774294670846	RAC1/MYL12B/MYL12A	0.567071888513908
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/88	50/9376	2.13090909090909	SAT1	0.780424442312016
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	1/88	51/9376	2.0891265597148	PLCG2	0.759110306130796
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	2/88	142/9376	1.50064020486556	PLCG2/RAC1	0.585114460673797
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/88	54/9376	1.97306397306397	HES1	0.697990633820597
Genetic Information Processing	Transcription	hsa03040	Spliceosome	3/88	243/9376	1.31537598204265	HSPA1B/HSPA1A/LSM3	0.484831573814256
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	1/88	56/9376	1.9025974025974	KRTCAP2	0.659395543498979
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	3/88	250/9376	1.27854545454545	LAPTM4B/BLOC1S1/HYAL2	0.434501938966511
NA	NA	hsa04518	Integrin signaling	2/88	154/9376	1.38370720188902	RAC1/ICAM2	0.467319198361785
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/88	59/9376	1.80585516178737	NME1	0.604381025245426
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	1/88	59/9376	1.80585516178737	GSTO1	0.604381025245426
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	2/88	156/9376	1.36596736596737	CLDN5/YWHAB	0.448647311687095
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	1/88	62/9376	1.71847507331378	HES1	0.552465680082212
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/88	63/9376	1.69119769119769	POLR2I	0.535788790108126
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	2/88	170/9376	1.25347593582888	PLCG2/GSTO1	0.324632189923384
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/88	70/9376	1.52207792207792	GSTO1	0.426745248963564
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	1/88	70/9376	1.52207792207792	RAC1	0.426745248963564
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/88	73/9376	1.45952677459527	GSTO1	0.383642410753615
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	1/88	73/9376	1.45952677459527	PLCG2	0.383642410753615
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	1/88	75/9376	1.42060606060606	GSTO1	0.355964924819734
Human Diseases	Cancer: specific types	hsa05214	Glioma	1/88	76/9376	1.40191387559809	PLCG2	0.342423997306348
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	1/88	77/9376	1.38370720188902	RAC1	0.3290736136118
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	1/88	78/9376	1.36596736596737	LSM3	0.315908100027342
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/88	79/9376	1.34867663981588	GSTO1	0.302922026225213
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	1/88	79/9376	1.34867663981588	SYT1	0.302922026225213
Human Diseases	Substance dependence	hsa05034	Alcoholism	2/88	191/9376	1.11565920990005	GNG5/GNG11	0.157189377985591
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	1/88	83/9376	1.28368017524644	CRAT	0.252671311784307
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	2/88	195/9376	1.09277389277389	PLCG2/RAC1	0.12742773473524
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	1/88	86/9376	1.23890063424947	PLCG2	0.216632964225696
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	1/88	86/9376	1.23890063424947	CDH2	0.216632964225696
NA	NA	hsa04082	Neuroactive ligand signaling	2/88	199/9376	1.07080858839653	GNG5/GNG11	0.0982715893263361
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	1/88	87/9376	1.22466039707419	RAC1	0.204912068763603
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	1/88	89/9376	1.19713993871297	TUBB2A	0.181885370331332
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	1/88	98/9376	1.08719851576994	PLCG2	0.084461894283905
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	1/88	99/9376	1.07621671258035	PLCG2	0.0742044418104362
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	1/88	99/9376	1.07621671258035	RAC1	0.0742044418104362
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	1/88	100/9376	1.06545454545455	TNFSF10	0.0640509111590347
NA	NA	hsa04081	Hormone signaling	2/88	219/9376	0.973017849730178	GNG5/GNG11	-0.0393267337454332
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	1/88	102/9376	1.0445632798574	RAC1	0.0440463127764659
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	1/88	103/9376	1.03442188879082	HSPB1	0.0341907833058668
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	1/88	105/9376	1.01471861471861	PLCG2	0.0147626446850751
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	1/88	105/9376	1.01471861471861	PLCG2	0.0147626446850751
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	1/88	109/9376	0.977481234361968	RAC1	-0.0230172862851127
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	1/88	110/9376	0.968595041322314	ID3	-0.0322488544278942
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	1/88	115/9376	0.926482213438735	NACA	-0.0772108390625445
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	1/88	122/9376	0.873323397913562	PLCG2	-0.13708105690418
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	1/88	122/9376	0.873323397913562	PLCG2	-0.13708105690418
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	1/88	125/9376	0.852363636363636	RAC1	-0.16174090792852
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	1/88	133/9376	0.801093643198906	TNFSF10	-0.224871220852406
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	1/88	137/9376	0.77770404777704	TNFSF10	-0.255120422613554
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	1/88	138/9376	0.772068511198946	YWHAB	-0.262555283623355
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	1/88	138/9376	0.772068511198946	RPS6	-0.262555283623355
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	1/88	138/9376	0.772068511198946	RAC1	-0.262555283623355
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	1/88	142/9376	0.750320102432779	RNF7	-0.291809002126318
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	1/88	144/9376	0.73989898989899	ID3	-0.306154930406945
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	1/88	148/9376	0.71990171990172	HES1	-0.334313087002232
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	1/88	149/9376	0.715070164734594	PLCG2	-0.341245294727642
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	1/88	154/9376	0.69185360094451	NME1	-0.375293263915157
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	1/88	157/9376	0.678633468442386	RAC1	-0.395252326739535
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	1/88	157/9376	0.678633468442386	HLA-B	-0.395252326739535
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	1/88	157/9376	0.678633468442386	YWHAB	-0.395252326739535
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	1/88	158/9376	0.67433831990794	YWHAB	-0.401830336973663
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	1/88	158/9376	0.67433831990794	RPS6	-0.401830336973663
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	1/88	163/9376	0.653653095370887	YWHAB	-0.434180633672424
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	1/88	169/9376	0.630446476600323	MAP1LC3A	-0.471875575813801
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	1/88	178/9376	0.598569969356486	RAC1	-0.526306856695174
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	2/88	333/9376	0.63991263991264	HLA-B/HES1	-0.651237797931298
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	1/88	201/9376	0.530076888285843	HHEX	-0.655522598462212
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	1/88	212/9376	0.502572898799314	RAC1	-0.713051182200977
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	1/88	226/9376	0.471440064360418	RAC1	-0.782895477601446
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	1/88	254/9376	0.419470293486041	PLCG2	-0.912981848908332
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	1/88	298/9376	0.357535082367297	TNFSF10	-1.09705482373766
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	1/88	323/9376	0.32986208837602	PLCG2	-1.19298521070117