category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	16/115	205/9376	6.36335100742312	MT-ATP6/MT-ND4/MT-CYB/MT-CO2/MT-CO1/MT-CO3/MT-ND3/MT-ND1/COL1A2/CYBB/MT-ND2/CTSD/MT-ND5/MT-ND4L/PDK4/PLCB4	8.65187867299753
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	15/115	227/9376	5.38747366404903	MT-ATP6/MT-ND4/MT-CYB/MT-CO2/MT-CO1/MT-CO3/MT-ND3/SLC26A2/MT-ND1/PTPRJ/MT-ND2/MGST1/SOD2/MT-ND5/MT-ND4L	7.4566928385748
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	11/115	138/9376	6.49880277252678	MT-ATP6/MT-ND4/MT-CYB/MT-CO2/MT-CO1/MT-CO3/MT-ND3/MT-ND1/MT-ND2/MT-ND5/MT-ND4L	7.25144109559223
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	13/115	216/9376	4.90692431561997	HSP90AA1/CCL3L1/CCL3/LYN/CD14/PPARG/CYBB/HSPA1B/SOD2/BCL2L1/ICAM1/PLCB4/ERO1A	6.47321084758104
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	13/115	235/9376	4.51019426456984	MT-ATP6/MT-ND4/MT-CYB/MT-CO2/MT-CO1/MT-CO3/MT-ND3/MT-ND1/PPARG/MT-ND2/MGLL/MT-ND5/MT-ND4L	6.07258839404416
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	14/115	275/9376	4.15064031620553	MT-ATP6/MT-ND4/MT-CYB/MT-CO2/MT-CO1/MT-CO3/MT-ND3/MT-ND1/CYBB/MT-ND2/HSPA1B/MT-ND5/MT-ND4L/IL1A	5.909166567383
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	14/115	308/9376	3.70592885375494	MT-ATP6/MT-ND4/MT-CYB/MT-CO2/MT-CO1/MT-CO3/MT-ND3/MT-ND1/PPARG/MT-ND2/SOD2/MT-ND5/MT-ND4L/PLCB4	5.38073486071774
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	13/115	268/9376	3.95483452303699	MT-ATP6/MT-ND4/MT-CYB/MT-CO2/MT-CO1/MT-CO3/MT-ND3/SLC11A2/MT-ND1/MT-ND2/MT-ND5/MT-ND4L/BCL2L1	5.46883306478239
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	15/115	388/9376	3.15194979829673	MT-ATP6/MT-ND4/MT-CYB/MT-CO2/MT-CO1/MT-CO3/MT-ND3/SLC11A2/MT-ND1/CYBB/MT-ND2/MT-ND5/MT-ND4L/IL1A/PLCB4	4.82416421584743
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	9/115	149/9376	4.92465713451999	MT-ND4/MT-ND3/MT-ND1/GABRP/MT-ND2/MGLL/MT-ND5/MT-ND4L/PLCB4	5.38108945905237
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	14/115	368/9376	3.10170132325142	MT-ATP6/MT-ND4/MT-CYB/MT-CO2/MT-CO1/MT-CO3/MT-ND3/MT-ND1/SQSTM1/MT-ND2/HNRNPA2B1/MT-ND5/MT-ND4L/BCL2L1	4.58338495170666
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	16/115	480/9376	2.71768115942029	MT-ATP6/MT-ND4/MT-CYB/MT-CO2/MT-CO1/MT-CO3/MT-ND3/MT-ND1/SQSTM1/CYBB/MT-ND2/MT-ND5/MT-ND4L/BCL2L1/IL1A/PLCB4	4.30498259470491
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	6/115	95/9376	5.14929061784897	CCL3L1/CCL3/HLA-DQB1/HLA-DQA1/ICAM1/IL1A	4.52943348733803
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	6/115	99/9376	4.94123847167325	HLA-DQB1/C3AR1/KRT19/DEFB1/HLA-DQA1/ICAM1	4.39290841170371
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	6/115	101/9376	4.84339216530349	COL1A2/PIM1/CYBB/ICAM1/IL1A/PLCB4	4.32737014520111
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	7/115	142/9376	4.01910593998775	HSP90AA1/SQSTM1/MGST1/ICAM1/IL1A/MEF2A/BMPR1B	4.03955202723714
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	6/115	105/9376	4.65888198757764	CCL4L2/LYN/CD14/CFLAR/BCL2L1/ICAM1	4.20131628409529
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	5/115	78/9376	5.2263099219621	HLA-DQB1/EEF1A1/CYBB/HLA-DQA1/IL1A	4.1765673402531
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	4/115	55/9376	5.92948616600791	UGCG/PLPP3/SGPP2/PSAP	4.08561424614828
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	7/115	181/9376	3.15311073744896	FCER1G/HLA-DQB1/CD14/IRAK2/CTSD/HLA-DQA1/IL1A	3.25938305719751
Human Diseases	Immune disease	hsa05310	Asthma	3/115	32/9376	7.64347826086957	FCER1G/HLA-DQB1/HLA-DQA1	4.19478502336087
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	5/115	100/9376	4.07652173913043	HLA-DQB1/CD14/CD24/HLA-DQA1/IL1A	3.44655516801903
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	5/115	109/9376	3.7399282010371	CCL4L2/CCL3L1/SPP1/CCL3/CD14	3.20618417461795
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	6/115	157/9376	3.11581279423982	MT-CYB/MT-CO2/MT-CO1/MT-CO3/PPARG/IL1A	2.97913904839905
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	3/115	44/9376	5.55889328063241	HLA-DQB1/HLA-DQA1/IL1A	3.37756733115335
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	3/115	45/9376	5.43536231884058	HLA-DQB1/HLA-DQA1/IL1A	3.32335611733632
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	4/115	82/9376	3.97709437963945	HSP90AA1/HLA-DQB1/HSPA1B/HLA-DQA1	3.01719800048681
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	4/115	87/9376	3.74852573713143	MT-CYB/MT-CO2/MT-CO1/MT-CO3	2.86999122704646
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	5/115	139/9376	2.93274945261182	HSP90AA1/KRT19/CTSD/HSPA1B/PLCB4	2.55813290211519
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	3/115	56/9376	4.36770186335404	EEF1A1/CD14/HSPA1B	2.81660088115047
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	6/115	193/9376	2.53462491552151	CCL4L2/CCL3L1/CCL3/LYN/CXCL16/PLCB4	2.40045861848092
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	4/115	100/9376	3.26121739130435	CCL4L2/CCL3L1/CCL3/TNFRSF10D	2.53318882388826
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	7/115	253/9376	2.25578278054649	UBE2D2/CD14/SQSTM1/CAST/BCL2L1/RRAGC/PLCB4	2.25637647486822
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	4/115	103/9376	3.16623047699451	CCL3L1/CCL3/CFLAR/PLCB4	2.4633082446439
NA	NA	hsa04518	Integrin signaling	5/115	154/9376	2.64709203839639	SPP1/COL1A2/FREM2/ICAM1/LIMS1	2.29652557199244
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	3/115	65/9376	3.76294314381271	PLPP3/GK/MGLL	2.49078406897374
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	3/115	66/9376	3.70592885375494	HLA-DQB1/HLA-DQA1/IL1A	2.45821077053662
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	4/115	112/9376	2.91180124223602	HLA-DQB1/HSPA1B/BCL2L1/HLA-DQA1	2.26807856331977
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	3/115	70/9376	3.49416149068323	HLA-DQB1/HLA-DQA1/ICAM1	2.33398296375896
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	5/115	168/9376	2.42650103519669	HSP90AA1/SQSTM1/CYBB/CFLAR/IL1A	2.07897703965448
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	5/115	169/9376	2.41214304090558	SQSTM1/CFLAR/CTSD/BCL2L1/RRAGC	2.06427991577298
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	5/115	174/9376	2.34282858570715	HSP90AA1/UBE2D2/HSPA1B/HSPH1/ERO1A	1.99232279416314
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	3/115	76/9376	3.21830663615561	PLIN2/GK/PPARG	2.16367743855288
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	4/115	125/9376	2.60897391304348	FCER1G/SGPP2/CTSD/PLCB4	2.01797269276983
Organismal Systems	Immune system	hsa04611	Platelet activation	4/115	126/9376	2.58826777087647	FCER1G/COL1A2/LYN/PLCB4	2.00006332249647
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/115	36/9376	4.52946859903382	ENPP3/GBE1	2.36424647919636
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	7/115	298/9376	1.91514444120222	CCL4L2/CCL3L1/CCL3/TNFRSF10D/CXCL16/IL1A/BMPR1B	1.78899161552414
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/115	37/9376	4.40705052878966	RIMKLB/ASRGL1	2.31384820763165
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	2/115	37/9376	4.40705052878966	ICAM1/PLCB4	2.31384820763165
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/115	38/9376	4.29107551487414	ENPP3/NT5C2	2.26520925433231
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	5/115	187/9376	2.17995814926761	HSP90AA1/CYBB/BCL2L1/P2RX7/PLCB4	1.8161800374297
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/115	39/9376	4.18104793756968	HLA-DQB1/HLA-DQA1	2.21821917037074
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	2/115	42/9376	3.8824016563147	SLC11A2/CYBB	2.08617560145968
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	3/115	89/9376	2.74821690278456	SPP1/COL1A2/FREM2	1.84653783975176
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/115	10/9376	8.15304347826087	PAPSS1	2.52185088997639
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	3/115	98/9376	2.49582963620231	PLPP3/LYN/MARCKS	1.65872199482129
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	4/115	155/9376	2.10401122019635	HLA-DQB1/CD14/CYBB/HLA-DQA1	1.54438630404739
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	2/115	50/9376	3.26121739130435	CKB/P4HA1	1.78642681848654
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	2/115	50/9376	3.26121739130435	HLA-DQB1/HLA-DQA1	1.78642681848654
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	4/115	157/9376	2.07720852949322	SQSTM1/NBN/IL1A/ZFP36L1	1.51674760745303
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	3/115	103/9376	2.37467285774588	COL1A2/CD14/PLCB4	1.56319607730374
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/115	54/9376	3.01964573268921	HLA-DQB1/HLA-DQA1	1.65852928041599
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	3/115	108/9376	2.26473429951691	EEF1A1/RANBP17/IPO11	1.47307133400842
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	3/115	109/9376	2.24395692062226	HSP90AA1/HLA-DQB1/HLA-DQA1	1.45564215562142
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	4/115	173/9376	1.88509675797939	HLA-DQB1/HLA-DQA1/ICAM1/IL1A	1.3093468471907
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	2/115	59/9376	2.76374355195284	ENPP3/NT5C2	1.51435959427991
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	3/115	115/9376	2.1268809073724	SGK1/PLCB4/MEF2A	1.35488868251924
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/115	60/9376	2.71768115942029	LYN/PLCB4	1.48733587576913
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	3/115	116/9376	2.10854572713643	CYBB/AFDN/ICAM1	1.33869835544295
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	3/115	116/9376	2.10854572713643	DLGAP1/PLCB4/HOMER2	1.33869835544295
Organismal Systems	Digestive system	hsa04978	Mineral absorption	2/115	61/9376	2.67312900926586	SLC11A2/MT1G	1.46085978342554
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	2/115	62/9376	2.63001402524544	HSPA1B/SOD2	1.43491007679521
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/115	16/9376	5.09565217391304	MIF	1.82705133514084
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/115	17/9376	4.79590792838875	PAPSS1	1.74554489475529
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	2/115	65/9376	2.50862876254181	SPP1/PLCB4	1.3600238195815
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	5/115	250/9376	1.63060869565217	SLC11A2/CTSD/CLCN7/RRAGC/PSAP	1.12614767220688
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	2/115	68/9376	2.39795396419437	PIM1/CD14	1.28921323492064
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	2/115	69/9376	2.36320100819156	FCER1G/LYN	1.26644170362704
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	3/115	128/9376	1.91086956521739	PAPSS1/ENPP3/NT5C2	1.15622640131017
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/115	70/9376	2.32944099378882	UGT2B7/MGST1	1.2440624403899
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	3/115	130/9376	1.88147157190635	RXFP1/COL1A2/PLCB4	1.12773915258362
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	3/115	133/9376	1.83903236351749	SGK1/SOD2/HOMER2	1.08593460591816
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	3/115	133/9376	1.83903236351749	FCER1G/CD48/ICAM1	1.08593460591816
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/115	73/9376	2.23371054198928	UGT2B7/MGST1	1.17914933832867
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/115	21/9376	3.8824016563147	ENPP3	1.47349228537803
Human Diseases	Infectious disease: viral	hsa05162	Measles	3/115	136/9376	1.79846547314578	HSPA1B/BCL2L1/IL1A	1.04518995253819
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	2/115	75/9376	2.17414492753623	MGST1/BCL2L1	1.13760929540012
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	2/115	75/9376	2.17414492753623	BCL2L1/PERP	1.13760929540012
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	3/115	137/9376	1.78533798794034	CFLAR/CTSD/BCL2L1	1.0318344454522
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	2/115	77/9376	2.11767363071711	MECOM/BCL2L1	1.09735680141456
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	4/115	205/9376	1.59083775185578	HLA-DQB1/LYN/HLA-DQA1/ICAM1	0.953108707113852
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	3/115	140/9376	1.74708074534161	SPP1/PLCB4/MEF2A	0.992419331528579
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/115	23/9376	3.54480151228733	NLN	1.36159510457266
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	2/115	78/9376	2.09052396878484	CD14/IL1A	1.0776887819139
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/115	79/9376	2.06406164006604	UGT2B7/MGST1	1.05831398080489
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	3/115	142/9376	1.72247397428047	SQSTM1/PPARG/IL1A	0.966667372872171
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	2/115	82/9376	1.98854718981972	UGT2B7/MGST1	1.00186363754855
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	2/115	83/9376	1.96458878994238	UBE2D2/MGA	0.983578222258598
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	3/115	149/9376	1.64155237817333	FCER1G/PLPP3/PLCB4	0.879631168097112
NA	NA	hsa04382	Cornified envelope formation	4/115	217/9376	1.50286515728311	UGCG/DSP/KRT19/KRT8	0.835147141150574
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	2/115	85/9376	1.9183631713555	ENPP3/NT5C2	0.947759853266911
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	2/115	86/9376	1.89605662285136	DSP/DSC2	0.930213073656072
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	4/115	224/9376	1.45590062111801	HLA-DQB1/BCL2L1/HLA-DQA1/ICAM1	0.769558790870509
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	2/115	90/9376	1.81178743961353	PPARG/SOD2	0.862292996385301
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	3/115	157/9376	1.55790639711991	PPARG/SGK1/CD24	0.785551886980018
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	4/115	227/9376	1.43665964374641	CCL4L2/CCL3L1/CCL3/PLCB4	0.742121112907969
NA	NA	hsa04517	IgSF CAM signaling	5/115	299/9376	1.36338519703359	SLAMF7/LYN/AFDN/CD48/ICAM1	0.711602187570921
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	3/115	158/9376	1.54804623004953	FNIP2/SGK1/RRAGC	0.774164054372015
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	5/115	300/9376	1.35884057971014	MECOM/MAP3K20/CD14/HSPA1B/IL1A	0.703915534527294
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/115	30/9376	2.71768115942029	FOLR3	1.05001597708468
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	3/115	160/9376	1.52869565217391	HLA-DQB1/HLA-DQA1/ICAM1	0.751623090421056
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	2/115	93/9376	1.75334268349696	PTPRJ/AFDN	0.813571057021021
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	2/115	93/9376	1.75334268349696	HLA-DQB1/HLA-DQA1	0.813571057021021
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/115	31/9376	2.63001402524544	UGT2B7	1.01295033309187
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/115	31/9376	2.63001402524544	PCCA	1.01295033309187
NA	NA	hsa04981	Folate transport and metabolism	1/115	31/9376	2.63001402524544	FOLR3	1.01295033309187
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	4/115	233/9376	1.39966411643963	COL1A2/DSP/ENO1/DSC2	0.688389716642721
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/115	32/9376	2.54782608695652	PCCA	0.977319023767324
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/115	32/9376	2.54782608695652	BCL2L1	0.977319023767324
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	3/115	168/9376	1.45590062111801	CISH/PIM1/BCL2L1	0.664427785387397
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/115	34/9376	2.39795396419437	BHLHE40	0.909951013991676
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	2/115	99/9376	1.64707949055775	PLPP3/GPCPD1	0.721235458737743
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/115	36/9376	2.26473429951691	UGT2B7	0.847193715102118
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	2/115	104/9376	1.56789297658863	PLPP3/GPCPD1	0.648936305619764
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/115	37/9376	2.20352526439483	MIF	0.817356464874228
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	1/115	37/9376	2.20352526439483	PPARG	0.817356464874228
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	2/115	105/9376	1.55296066252588	SQSTM1/BCL2L1	0.634937842713028
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	3/115	178/9376	1.37410845139228	TBL1XR1/LGR4/PLCB4	0.561521557688839
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	2/115	106/9376	1.5383100902379	HSP90AA1/FOLR3	0.621085231196756
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/115	38/9376	2.14553775743707	GNPDA1	0.78846040378164
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/115	38/9376	2.14553775743707	SGK1	0.78846040378164
NA	NA	hsa04519	Cadherin signaling	6/115	404/9376	1.21084804132587	GABRP/DSP/KRT19/KRT8/DSC2/AFDN	0.482748838310588
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	3/115	180/9376	1.35884057971014	HLA-DQB1/BCL2L1/HLA-DQA1	0.541681417331001
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	2/115	110/9376	1.48237154150198	CYBB/ENO1	0.5670710661658
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/115	41/9376	1.98854718981972	NBN	0.706867133795254
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/115	41/9376	1.98854718981972	GABRP	0.706867133795254
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/115	43/9376	1.89605662285136	PLPP3	0.656242971796147
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	2/115	116/9376	1.40569715142429	ENO1/PCCA	0.489926663487775
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/115	44/9376	1.85296442687747	GTF2H1	0.631939509331449
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/115	45/9376	1.81178743961353	DEFB1	0.608261188033367
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	2/115	119/9376	1.37025940811107	CFLAR/ICAM1	0.452949795224035
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/115	46/9376	1.77240075614367	UGT2B7	0.585175857897046
NA	NA	hsa04082	Neuroactive ligand signaling	3/115	199/9376	1.22910203189862	P2RX4/GABRP/PLCB4	0.36400783329102
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/115	48/9376	1.69855072463768	PCCA	0.540667063304631
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/115	48/9376	1.69855072463768	PLCB4	0.540667063304631
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	3/115	201/9376	1.21687216093446	CD14/PPARG/BCL2L1	0.346341405756481
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	5/115	362/9376	1.12611097766034	HSP90AA1/SPP1/COL1A2/SGK1/BCL2L1	0.272680459517338
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	1/115	50/9376	1.63060869565217	ICAM1	0.498199018907261
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/115	51/9376	1.59863597612958	PLPP3	0.477671243702481
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	1/115	51/9376	1.59863597612958	ERO1A	0.477671243702481
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	5/115	370/9376	1.10176263219741	P2RX4/RXFP1/GABRP/C3AR1/P2RX7	0.222550635585784
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	1/115	53/9376	1.5383100902379	PLCB4	0.437923478140428
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	3/115	217/9376	1.12714886796233	HSP90AA1/UGT2B7/MGST1	0.211165979669358
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	1/115	59/9376	1.38187177597642	MGST1	0.327877137860721
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1/115	59/9376	1.38187177597642	MGLL	0.327877137860721
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	2/115	142/9376	1.14831598285364	UBE2D2/UBE2W	0.198446209280929
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	2/115	143/9376	1.14028580115537	HLA-DQB1/HLA-DQA1	0.188371820039364
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	2/115	144/9376	1.13236714975845	C3AR1/CD14	0.178368919610909
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/115	63/9376	1.29413388543823	MECOM	0.26102142087598
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/115	63/9376	1.29413388543823	GTF2H1	0.26102142087598
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	1/115	65/9376	1.2543143812709	PLCB4	0.229263570189274
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/115	66/9376	1.23530961791831	UGT2B7	0.213767866207927
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	1/115	67/9376	1.21687216093446	ENO1	0.198515905618264
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	1/115	67/9376	1.21687216093446	PLCB4	0.198515905618264
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/115	68/9376	1.19897698209719	UGT2B7	0.183499432266421
Organismal Systems	Endocrine system	hsa04924	Renin secretion	1/115	69/9376	1.18160050409578	PLCB4	0.168710593965662
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	1/115	71/9376	1.14831598285364	CISH	0.139786282704247
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	1/115	71/9376	1.14831598285364	LYN	0.139786282704247
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	3/115	248/9376	0.986255259467041	HSP90AA1/CD14/ANXA2	-0.0244444453135802
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	1/115	73/9376	1.11685527099464	EML4	0.111687313015393
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	3/115	250/9376	0.978365217391304	FOLR3/HSPA1B/ARFGEF2	-0.0386356233928671
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/115	75/9376	1.08707246376812	ENO1	0.0843630473827873
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	1/115	75/9376	1.08707246376812	PLCB4	0.0843630473827873
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	3/115	254/9376	0.962957891133174	P2RX4/P2RX7/PLCB4	-0.066691908311755
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	2/115	166/9376	0.982294394971189	PLCB4/MEF2A	-0.0256472388927242
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	1/115	76/9376	1.07276887871854	PLCB4	0.0709768336558506
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	1/115	77/9376	1.05883681535855	BCL2L1	0.0577672924660992
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/115	78/9376	1.04526198439242	PLCB4	0.0447292624674956
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	1/115	78/9376	1.04526198439242	ENO1	0.0447292624674956
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	2/115	170/9376	0.959181585677749	MGST1/BCL2L1	-0.0598481487703829
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	1/115	80/9376	1.01913043478261	BCL2L1	0.0191481752099759
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	1/115	83/9376	0.982294394971189	SOD2	-0.0180541674336596
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	1/115	83/9376	0.982294394971189	CCL4L2	-0.0180541674336596
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/115	86/9376	0.948028311425682	PLCB4	-0.05395277813803
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	1/115	86/9376	0.948028311425682	PLCB4	-0.05395277813803
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	1/115	88/9376	0.926482213438735	C3AR1	-0.0772108390625445
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	1/115	89/9376	0.916072300928188	PLCB4	-0.0886478513578922
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	1/115	89/9376	0.916072300928188	GABRP	-0.0886478513578922
Organismal Systems	Digestive system	hsa04976	Bile secretion	1/115	90/9376	0.905893719806763	UGT2B7	-0.0999611257414048
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	1/115	90/9376	0.905893719806763	EML4	-0.0999611257414048
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	1/115	91/9376	0.895938843764931	LYN	-0.111153720920304
Human Diseases	Substance dependence	hsa05032	Morphine addiction	1/115	91/9376	0.895938843764931	GABRP	-0.111153720920304
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	1/115	93/9376	0.876671341748481	PLCB4	-0.133188559539621
Organismal Systems	Digestive system	hsa04970	Salivary secretion	1/115	93/9376	0.876671341748481	PLCB4	-0.133188559539621
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	1/115	93/9376	0.876671341748481	BCL2L1	-0.133188559539621
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	1/115	94/9376	0.867345050878816	HSP90AA1	-0.144036386798752
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	2/115	195/9376	0.836209587513935	CYBB/PLCB4	-0.257552876614945
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	2/115	196/9376	0.831943212067436	LYN/ICAM1	-0.264952712460534
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	1/115	97/9376	0.840519946212461	PLCB4	-0.175932984276866
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	1/115	98/9376	0.831943212067436	PLCB4	-0.186357780175082
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	1/115	98/9376	0.831943212067436	PLCB4	-0.186357780175082
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	1/115	99/9376	0.823539745278876	PLCB4	-0.19668277950375
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	1/115	101/9376	0.807232027550581	PLCB4	-0.217042220270722
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	2/115	203/9376	0.803255515099593	SPP1/COL1A2	-0.315791550525041
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	1/115	102/9376	0.799317988064791	PLCB4	-0.227080897883939
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	2/115	205/9376	0.79541887592789	LYN/GTF2H1	-0.330019620533427
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	1/115	103/9376	0.791557619248628	COL1A2	-0.237028257376584
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	1/115	105/9376	0.77648033126294	FCER1G	-0.256656767632539
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	1/115	107/9376	0.761966680211296	PLCB4	-0.275942641728005
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	2/115	212/9376	0.76915504511895	AFDN/PLCB4	-0.378836132210472
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	1/115	110/9376	0.741185770750988	BMPR1B	-0.30425936916205
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	1/115	110/9376	0.741185770750988	HSP90AA1	-0.30425936916205
NA	NA	hsa04081	Hormone signaling	2/115	219/9376	0.744570180663093	PLCB4/BMPR1B	-0.426209045730292
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	1/115	115/9376	0.708960302457467	PLCB4	-0.349927299135513
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	1/115	115/9376	0.708960302457467	PLCB4	-0.349927299135513
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	1/115	120/9376	0.679420289855072	IRAK2	-0.393840703225235
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	1/115	122/9376	0.668282252316465	PPARG	-0.41095047990864
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	1/115	122/9376	0.668282252316465	PLCB4	-0.41095047990864
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	1/115	122/9376	0.668282252316465	PLCB4	-0.41095047990864
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	2/115	238/9376	0.685129704055535	AFDN/BCL2L1	-0.548277230397957
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	2/115	238/9376	0.685129704055535	C3AR1/CYBB	-0.548277230397957
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	1/115	133/9376	0.613010787839163	PLCB4	-0.500868614698791
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	1/115	134/9376	0.608436080467229	PLCB4	-0.508718698036593
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	1/115	144/9376	0.566183574879227	BMPR1B	-0.584581349673708
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	1/115	144/9376	0.566183574879227	PLCB4	-0.584581349673708
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	1/115	154/9376	0.529418407679277	UGT2B7	-0.656127669420125
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	1/115	154/9376	0.529418407679277	PLCB4	-0.656127669420125
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	1/115	154/9376	0.529418407679277	PLCB4	-0.656127669420125
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	1/115	155/9376	0.526002805049088	PLCB4	-0.663068239386983
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	1/115	156/9376	0.52263099219621	CFLAR	-0.669972034153299
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	1/115	157/9376	0.519302132373304	BMPR1B	-0.676839553966006
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	1/115	170/9376	0.479590792838875	AFDN	-0.763026397982302
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	1/115	184/9376	0.443100189035917	BMPR1B	-0.850132443482725
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	2/115	323/9376	0.504832413514605	PIM1/MARCKS	-1.00916650011108
Cellular Processes	Cell motility	hsa04814	Motor proteins	1/115	194/9376	0.42025997310623	KIFC3	-0.909224486655544
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	2/115	333/9376	0.489672280976629	SPP1/COL1A2	-1.05662437664977
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	1/115	204/9376	0.399658994032396	COL1A2	-0.966021262653378
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	1/115	214/9376	0.380983340105648	BCL2L1	-1.02075072435861
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	1/115	226/9376	0.360754136206233	AFDN	-1.08396988176371
Genetic Information Processing	Transcription	hsa03040	Spliceosome	1/115	243/9376	0.335516192521023	HSPA1B	-1.16946283995585