category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
NA	NA	hsa04519	Cadherin signaling	26/198	404/9376	3.04750475047505	GABRG3/PCDH10/MAPK10/MET/ACTR3C/TEAD1/USH1C/WWTR1/YAP1/CTNND2/EGFR/PCDH7/AFDN/DSP/PRICKLE2/TMC1/CTNND1/MYO1E/TJP1/FZD3/VCL/IGF1R/TCF7L2/RERE/CDH26/PTK2	6.17895702673433
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	20/198	308/9376	3.07490489308671	MT-ATP8/MT-ND5/MT-ND4L/MAPK10/MT-ATP6/MT-ND2/MT-ND1/PLCB1/MT-ND4/DNAH3/DNAH11/DNAH7/GRM5/DNAH6/DNAH5/DNAI2/PLCB4/MT-CYB/DNAH9/MT-CO1	5.43828550644908
NA	NA	hsa04517	IgSF CAM signaling	19/198	299/9376	3.00908753082666	CNTN1/SLIT2/MAPK10/GRIP1/ANK3/FOXO1/ANK2/ACTR3C/MYH14/NTN1/AFDN/MAGI1/UNC5B/TJP1/NRCAM/VCL/EPB41L2/CXADR/PTK2	5.18570122675726
NA	NA	hsa04518	Integrin signaling	13/198	154/9376	3.99737636101272	ITGB8/LAMA2/MET/LAMA3/FLNB/EGFR/VCL/IGF1R/LAMC1/C3/PARVA/LAMB3/PTK2	5.50849914075648
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	10/198	93/9376	5.0917779950038	PTPRM/MET/EGFR/AFDN/FER/CTNND1/TJP1/VCL/IGF1R/TCF7L2	5.82443185086778
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	14/198	203/9376	3.26576105886451	ITGB8/MAPK10/LAMA2/MET/LAMA3/FLNB/DOCK1/EGFR/VCL/IGF1R/LAMC1/PARVA/LAMB3/PTK2	4.79347688266321
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	14/198	205/9376	3.23389997536339	MT-ATP8/MT-ND5/MT-ND4L/MAPK10/MT-ATP6/MT-ND2/MT-ND1/PLCB1/MT-ND4/CD36/PLCB4/MT-CYB/MT-CO1/ATP2A2	4.74981302179023
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	7/198	53/9376	6.25424051839146	PLCB1/ESR1/ADCY9/ATP2B2/PLCB4/DNM3/ATP2B3	5.63396634724176
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	19/198	368/9376	2.44488361879666	MT-ATP8/MT-ND5/MT-ND4L/MT-ATP6/MT-ND2/MT-ND1/MT-ND4/DNAH3/DNAH11/DNAH7/NRG4/ERBB4/DNAH6/DNAH5/DNAI2/MT-CYB/DNAH9/MT-CO1/NRG2	4.15323776701528
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	11/198	149/9376	3.49589858314691	GABRG3/MT-ND5/MT-ND4L/MAPK10/MT-ND2/MT-ND1/PLCB1/MT-ND4/ADCY9/GRM5/PLCB4	4.51059687885719
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	14/198	235/9376	2.82106168063615	MT-ATP8/MT-ND5/RPS6KA6/MT-ND4L/MT-ATP6/MT-ND2/MT-ND1/ACSL5/MT-ND4/ADCY9/PRKAA2/MT-CYB/RPS6KA2/MT-CO1	4.15246460444595
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	22/198	480/9376	2.17037037037037	MT-ATP8/MT-ND5/MT-ND4L/MAPK10/MT-ATP6/MT-ND2/MT-ND1/PLCB1/MT-ND4/DNAH3/DNAH11/DNAH7/GRM5/DNAH6/DNAH5/DNAI2/PLCB4/MT-CYB/DNAH9/FZD3/MT-CO1/ATP2A2	3.86625733260666
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	10/198	138/9376	3.43141560532865	MT-ATP8/MT-ND5/MT-ND4L/MT-ATP6/MT-ND2/MT-ND1/ATP6V1C2/MT-ND4/MT-CYB/MT-CO1	4.2262381948311
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	9/198	116/9376	3.67398119122257	DLGAP1/GRIK2/PLCB1/ADCY9/GRM5/HOMER1/PLCB4/HOMER2/SHANK2	4.25623948202504
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	13/198	227/9376	2.71187647399101	MT-ATP8/MT-ND5/MT-ND4L/MAPK10/MT-ATP6/MT-ND2/MT-ND1/MT-ND4/MET/EGFR/MT-CYB/MT-CO1/PTK2	3.83480023217097
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	8/198	103/9376	3.67794449347847	PLCB1/LAMA2/LAMA3/PLCB4/VCL/LAMC1/LAMB3/PTK2	4.01378642807747
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	7/198	86/9376	3.85435752877613	DTNA/ITGB8/LAMA2/SGCD/DSP/TCF7L2/ATP2A2	3.90565561198396
Cellular Processes	Cell motility	hsa04814	Motor proteins	11/198	194/9376	2.68499427262314	DNAH3/DNAH11/DNAH7/MYH14/KIF6/DYNC2H1/DNAH6/DNAH5/DNAI2/DNAH9/MYO1E	3.48317148552673
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	13/198	253/9376	2.43318561105122	RPS6KA5/MAPK10/PLCB1/FOXO1/FNBP1L/ACTR3C/PLCB4/DOCK1/EGFR/UBE2D2/VCL/C3/PTK2	3.39420500152045
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	11/198	212/9376	2.45702306079665	PLCB1/MET/ADCY9/PLCB4/EGFR/FGFR2/AFDN/MAGI1/CTNND1/IGF1R/TIAM1	3.1516357807136
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	10/198	184/9376	2.57356170399649	SLIT2/MET/NTN1/SEMA6A/BOC/UNC5B/FZD3/SEMA3E/BMPR1B/PTK2	3.16615292817923
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	7/198	102/9376	3.24975242622301	KCNMA1/PLCB1/ADCY9/ATP2B2/PLCB4/ATP2B3/ATP2A2	3.35540908131501
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	6/198	78/9376	3.64257964257964	MET/ACTR3C/DOCK1/DNM3/VCL/PTK2	3.4421106108962
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	6/198	80/9376	3.55151515151515	MET/EGFR/FGFR2/IGF1R/NRG2/IL6R	3.36619518348341
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	4/198	37/9376	5.11930111930112	PLCB1/PLCB4/IDO2/APOL1	3.68738445814737
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	12/198	254/9376	2.23717489859222	PLCB1/MET/ADCY9/GRM5/ERBB4/TFEB/ATP2B2/PLCB4/EGFR/FGFR2/ATP2B3/ATP2A2	2.93593969561654
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	16/198	388/9376	1.95272310736228	MT-ATP8/MT-ND5/MT-ND4L/MAPK10/MT-ATP6/MT-ND2/MT-ND1/PLCB1/MT-ND4/GRM5/PLCB4/BACE2/MT-CYB/FZD3/MT-CO1/ATP2A2	2.81510913656375
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	6/198	86/9376	3.30373502466526	MAPK10/NRG4/ERBB4/EGFR/NRG2/PTK2	3.15223146956849
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	6/198	86/9376	3.30373502466526	KCNMA1/PLCB1/KCNMB2/ADCY9/PCLO/PLCB4	3.15223146956849
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	11/198	232/9376	2.24521072796935	ITGB8/SCIN/SPATA13/ACTR3C/MYH14/DOCK1/EGFR/FGFR2/VCL/TIAM1/PTK2	2.8207392652491
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	11/198	233/9376	2.23557463042442	DTNA/ITGB8/LAMA2/ANK3/ANK2/SGCD/MYH14/SYNE1/DSP/VCL/MYOM1	2.80508993444108
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	6/198	89/9376	3.19237316990126	ITGB8/LAMA2/LAMA3/CD36/LAMC1/LAMB3	3.05222092757925
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	6/198	89/9376	3.19237316990126	PLCB1/ADCY9/GRM5/PLCB4/EGFR/TJP1	3.05222092757925
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	10/198	204/9376	2.32125173301644	ESR1/ANK3/MET/ANK2/ERBB4/EGFR/FZD3/IGF1R/TIAM1/PTK2	2.80228845316967
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	12/198	268/9376	2.12030755314337	MT-ATP8/MT-ND5/MT-ND4L/MAPK10/MT-ATP6/MT-ND2/MT-ND1/MT-ND4/MAOA/MT-CYB/MT-CO1/SLC18A2	2.73298568359628
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	9/198	178/9376	2.39427987742594	MAPK10/PLCB1/CTNND2/TLE4/PLCB4/PRICKLE2/LGR4/FZD3/TCF7L2	2.75840140123061
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	5/198	67/9376	3.53384592190562	RPS6KA6/PLCB1/GRM5/PLCB4/RPS6KA2	3.05710457952331
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	6/198	93/9376	3.05506679700228	MAPK10/PLCB1/ADCY9/MAP3K4/PLCB4/EGFR	2.92528004274332
Organismal Systems	Digestive system	hsa04970	Salivary secretion	6/198	93/9376	3.05506679700228	KCNMA1/PLCB1/ADCY9/ATP2B2/PLCB4/ATP2B3	2.92528004274332
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	6/198	93/9376	3.05506679700228	LAMA2/LAMA3/RARB/LAMC1/LAMB3/PTK2	2.92528004274332
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	8/198	154/9376	2.45992391446937	RPS6KA5/PLCB1/ADCY9/ATP2B2/PLCB4/KCNE1/ATP2B3/ATP2A2	2.68300962569385
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	6/198	97/9376	2.92908466104342	RPS6KA5/PLCB1/ADCY9/PLCB4/PER2/NOS1AP	2.80498649231924
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	5/198	71/9376	3.33475601081235	MAPK10/ATP6V1C2/MET/EGFR/TJP1	2.90039197245827
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	6/198	99/9376	2.8699112335476	MAPK10/ESR1/ADCY9/EGFR/IGF1R/PTK2	2.74712876442726
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	6/198	99/9376	2.8699112335476	DTNA/ITGB8/LAMA2/SGCD/PRKAA2/ATP2A2	2.74712876442726
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	14/198	362/9376	1.83135219599308	ITGB8/LAMA2/MET/LAMA3/ERBB4/PRKAA2/EGFR/FGFR2/MAGI1/IGF1R/LAMC1/IL6R/LAMB3/PTK2	2.3693256897144
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	7/198	133/9376	2.4922913343966	MAPK10/FOXO1/HOMER1/PRKAA2/EGFR/HOMER2/IGF1R	2.54575829599895
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	3/198	29/9376	4.89864158829676	TEAD1/WWTR1/YAP1	3.08830650012639
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	6/198	105/9376	2.70591630591631	DTNA/ITGB8/LAMA2/ADCY9/SGCD/ATP2A2	2.58186354836651
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	13/198	333/9376	1.84863651530318	ITGB8/LAMA2/ATP6V1C2/FOXO1/MAML2/LAMA3/EGFR/MAGI1/FZD3/LAMC1/TCF7L2/LAMB3/PTK2	2.31596383156977
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	8/198	166/9376	2.28209808932701	KCNMA1/PLCB1/KCNMB2/ADCY9/ATP2B2/PLCB4/ATP2B3/ATP2A2	2.44787754553434
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	6/198	106/9376	2.68038879359634	FOXO1/GRM5/EGFR/FGFR2/IGF1R/TCF7L2	2.55544800438222
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	12/198	300/9376	1.89414141414141	RPS6KA5/RPS6KA6/MECOM/MAPK10/MET/MAP3K4/ERBB4/EGFR/FGFR2/MAP3K20/RPS6KA2/IGF1R	2.3118720849843
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	8/198	170/9376	2.22840166369578	MAPK10/ACTR3C/MYH14/PRKAA2/AFDN/MAGI1/TJP1/TIAM1	2.37396098928497
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	6/198	109/9376	2.60661662496525	RPS6KA6/MAPK10/FOXO1/PRKAA2/CD36/RPS6KA2	2.47799331690648
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	10/198	238/9376	1.98964434258552	MAPK10/MET/RALGAPA2/RASAL2/EGFR/FGFR2/AFDN/RGL1/IGF1R/TIAM1	2.27136147119339
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	11/198	275/9376	1.89414141414141	MT-ATP8/MT-ND5/MT-ND4L/MAPK10/MT-ATP6/MT-ND2/MT-ND1/MT-ND4/MT-CYB/MT-CO1/LAMC1	2.21040679534366
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	7/198	149/9376	2.22466273472985	PLCB1/ADCY9/DGKH/GRM5/PLCB4/EGFR/DNM3	2.21321489031032
Organismal Systems	Digestive system	hsa04978	Mineral absorption	4/198	61/9376	3.10514985924822	STEAP2/ATP2B2/ATP2B3/MT1M	2.42270598355731
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	4/198	62/9376	3.05506679700228	FOXO1/ADCY9/PRKAA2/IGF1R	2.38450302194634
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	6/198	122/9376	2.32886239443617	THRB/PLCB1/ESR1/FOXO1/PLCB4/ATP2A2	2.16989833150258
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	7/198	155/9376	2.1385467579016	PBX1/PLCB1/ADCY9/PLCB4/EGFR/FZD3/TCF7L2	2.09928747996266
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	4/198	65/9376	2.91406371406371	PBX1/PLCB1/ADCY9/PLCB4	2.27435949295406
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	7/198	157/9376	2.11130412404298	PBX1/CD36/DOCK1/ALOX15/ATP8A2/ATP2A2/PTK2	2.06245770587584
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/198	17/9376	5.57100415923945	MYH14/PCDH7	2.77054724347172
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	7/198	158/9376	2.09794143971359	RPS6KA6/ATP6V1C2/PRKAA2/RPS6KA2/FZD3/IGF1R/DEPTOR	2.04424797041516
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	7/198	160/9376	2.07171717171717	CNTN1/ITGB8/PTPRM/NRXN3/ALCAM/NRCAM/CXADR	2.00822863002788
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	5/198	98/9376	2.41599670171099	PLCB1/ADCY9/ATP2B2/PLCB4/ATP2B3	2.06962805164704
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	6/198	130/9376	2.18554778554779	MAPK10/PLCB1/ADCY9/PLCB4/EGFR/RXFP1	1.99920809630516
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	4/198	70/9376	2.70591630591631	MAPK10/ACSL5/PRKAA2/CD36	2.10411476041596
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	4/198	70/9376	2.70591630591631	DTNA/LAMA2/SGCD/CXADR	2.10411476041596
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	5/198	101/9376	2.34423442344234	PLCB1/ADCY9/PLCB4/FZD3/TCF7L2	1.99490834527278
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	8/198	201/9376	1.88471782501633	PBX1/FOXO1/MET/MEIS1/PER2/MLLT1/IGF1R/PTK2	1.86227569955988
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	6/198	134/9376	2.12030755314337	KCNMA1/PLCB1/KCNMB2/ADCY9/MYH14/PLCB4	1.91845178002281
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	5/198	103/9376	2.29871530842405	MAPK10/PLCB1/PLCB4/C3/CFLAR	1.94655486384553
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	6/198	138/9376	2.05884936319719	RPS6KA6/MAPK10/ACTR3C/DOCK1/RPS6KA2/PTK2	1.8404708810412
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	4/198	76/9376	2.4922913343966	SLC26A7/PLCB1/ADCY9/PLCB4	1.91850592859174
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	3/198	48/9376	2.95959595959596	PCCA/MCCC2/AUH	1.99911184289773
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	5/198	110/9376	2.1524334251607	RPS6KA6/MAPK10/ADCY9/RPS6KA2/IGF1R	1.78570719033031
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	5/198	112/9376	2.11399711399711	MAPK10/LAMA2/LAMA3/LAMC1/LAMB3	1.74195932727443
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	3/198	51/9376	2.78550207961973	ATP6V1C2/ADCY9/TJP1	1.87786875001686
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	5/198	115/9376	2.05884936319719	PLCB1/MAOA/PLCB4/ALOX15/SLC18A2	1.67802475900234
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	5/198	115/9376	2.05884936319719	PLCB1/ADCY9/PLCB4/EGFR/SLC12A3	1.67802475900234
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	6/198	150/9376	1.89414141414141	MET/RARB/EGFR/FGFR2/FZD3/TCF7L2	1.62139683787619
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	6/198	154/9376	1.84494293585203	PLCB1/ADCY9/PRKAA2/PLCB4/EGFR/EEF2K	1.5528138196688
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	6/198	157/9376	1.80968924917969	TEAD1/WWTR1/YAP1/FZD3/TCF7L2/BMPR1B	1.50269381279728
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	5/198	122/9376	1.94071866203014	FOXO1/PRKAA2/CD36/IGF1R/EEF2K	1.53609874408301
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	5/198	122/9376	1.94071866203014	MAPK10/PLCB1/ADCY9/PLCB4/PTK2	1.53609874408301
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	4/198	90/9376	2.10460157126824	FOXO1/ADCY9/PRKAA2/IGF1R	1.54652440702848
NA	NA	hsa04082	Neuroactive ligand signaling	7/198	199/9376	1.66570224861682	GABRG3/GRIK2/PLCB1/ADCY9/GRM5/PLCB4/SLC18A2	1.3941207874503
Organismal Systems	Nervous system	hsa04730	Long-term depression	3/198	60/9376	2.36767676767677	PLCB1/PLCB4/IGF1R	1.56094845305393
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	5/198	128/9376	1.84974747474747	ADCY9/PAPSS1/AK9/ADK/NME7	1.42172357050808
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	5/198	133/9376	1.78020809599757	MAPK10/PLCB1/MAOA/PLCB4/SLC18A2	1.3309875807826
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	4/198	99/9376	1.9132741556984	MAPK10/PLCB1/ADCY9/PLCB4	1.34171165877603
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/198	34/9376	2.78550207961973	PRKAA2/PER2	1.53187770000024
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/198	66/9376	2.1524334251607	SULT1E1/HSD11B2/UGT2B7	1.37993039266586
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	4/198	101/9376	1.87538753875388	MAPK10/PLCB1/FOXO1/PLCB4	1.29911708549756
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	5/198	139/9376	1.70336458106242	PLCB1/ESR1/ADCY9/PLCB4/EGFR	1.22706234755615
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	7/198	217/9376	1.52753339850114	RPS6KA6/ESR1/ADCY9/UGT2B7/EGFR/KLF5/RPS6KA2	1.15478199635702
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/198	36/9376	2.6307519640853	CRPPA/UGT2B7	1.43982572650742
Organismal Systems	Endocrine system	hsa04924	Renin secretion	3/198	69/9376	2.05884936319719	KCNMA1/PLCB1/PLCB4	1.29657628780625
NA	NA	hsa04081	Hormone signaling	7/198	219/9376	1.5135833218025	THRB/PLCB1/ESR1/ADCY9/PLCB4/IGF1R/BMPR1B	1.12953727915052
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/198	37/9376	2.55965055965056	MAOA/PNMT	1.39611819268314
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	5/198	144/9376	1.64421997755331	MEIS1/FGFR2/FZD3/IGF1R/BMPR1B	1.1442258188207
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	5/198	144/9376	1.64421997755331	MAPK10/FOXO1/PRKAA2/TCF7L2/C3	1.1442258188207
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	5/198	144/9376	1.64421997755331	FGF14/MAPK10/PLCB1/PLCB4/ATP2A2	1.1442258188207
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	3/198	71/9376	2.00085360648741	MAPK10/ESR1/SOCS6	1.24332810470074
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	3/198	71/9376	2.00085360648741	MET/EGFR/FGFR2	1.24332810470074
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	4/198	107/9376	1.77022562069291	PLCB1/FOXO1/PRKAA2/PLCB4	1.17689472221914
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/198	10/9376	4.73535353535354	PAPSS1	1.73579663516345
Human Diseases	Cancer: specific types	hsa05218	Melanoma	3/198	73/9376	1.94603569946036	MET/EGFR/IGF1R	1.19179525340277
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	3/198	73/9376	1.94603569946036	MET/RARB/EGFR	1.19179525340277
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	7/198	226/9376	1.46670242245463	MAPK10/ADCY9/ATP2B2/AFDN/ATP2B3/TIAM1/ATP2A2	1.04310477704842
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	5/198	148/9376	1.5997815997816	ESR1/EGFR/FZD3/IGF1R/TCF7L2	1.08022546164411
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	3/198	75/9376	1.89414141414141	PLCB1/ADCY9/PLCB4	1.14186885311413
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	2/198	41/9376	2.30992855383099	RPS6KA5/EGFR	1.23460088192597
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/198	42/9376	2.25493025493025	MAOA/IDO2	1.19716646624912
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	2/198	42/9376	2.25493025493025	ACSL5/ALOX15	1.19716646624912
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	3/198	78/9376	1.82128982128982	PLCB1/PLCH1/PLCB4	1.06977680556227
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	4/198	116/9376	1.63288052943225	AFDN/CTNND1/VCL/PTK2	1.00737099633184
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	5/198	155/9376	1.52753339850114	ATP6V1C2/DYNC2H1/CD36/STX18/C3	0.97268228208447
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	3/198	79/9376	1.79823551975451	ATP6V1C2/DNM3/SLC18A2	1.04644735803212
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	5/198	157/9376	1.50807437431641	MAPK10/PRKAA2/MT-CYB/MT-CO1/IL6R	0.942929919718724
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	2/198	44/9376	2.1524334251607	CHST9/B4GALNT3	1.12537956775343
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	2/198	44/9376	2.1524334251607	ADCY9/DYNC2H1	1.12537956775343
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/198	45/9376	2.10460157126824	DEFB1/ABCA10	1.09091779370246
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	4/198	120/9376	1.57845117845118	RPS6KA5/RPS6KA6/MAPK10/RPS6KA2	0.936677022804099
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	3/198	85/9376	1.67130124777184	AK9/ADK/NME7	0.913145312135643
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/198	48/9376	1.97306397306397	PLCB1/PLCB4	0.992686121301452
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	4/198	125/9376	1.51531313131313	SGMS2/MAPK10/PLCB1/PLCB4	0.851875409721643
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	7/198	250/9376	1.32589898989899	ACTR3C/AGAP1/EGFR/FGFR2/AGAP9/DNM3/IGF1R	0.767108850030051
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	2/198	49/9376	1.93279736136879	MAOA/SLC18A2	0.961520542496928
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	3/198	87/9376	1.63288052943225	MT-CYB/MT-CO1/ATP2A2	0.871045991170402
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	3/198	87/9376	1.63288052943225	MAPK10/EGFR/TCF7L2	0.871045991170402
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	5/198	168/9376	1.40933140933141	EGFR/SOCS6/IL5RA/IL20RA/IL6R	0.786305408575274
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	2/198	50/9376	1.89414141414141	MET/CD36	0.931081535031579
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	5/198	169/9376	1.40099217022294	MAPK10/PRKAA2/IGF1R/DEPTOR/CFLAR	0.772617213999431
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/198	16/9376	2.95959595959596	MAOA	1.15221310091783
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	5/198	170/9376	1.39275103980986	MET/EGFR/FZD3/IGF1R/TCF7L2	0.759015291630728
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	2/198	52/9376	1.82128982128982	ADCY9/IGF1R	0.872250418410957
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/198	17/9376	2.78550207961973	PAPSS1	1.08221688114292
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/198	18/9376	2.6307519640853	ACSL5	1.01713090197543
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	4/198	138/9376	1.37256624213146	RPS6KA6/ADCY9/RPS6KA2/IGF1R	0.647587224146255
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	3/198	98/9376	1.44959802102659	PLCB1/DGKH/PLCB4	0.657134776625737
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	3/198	98/9376	1.44959802102659	SCIN/ACTR3C/DOCK1	0.657134776625737
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	4/198	140/9376	1.35295815295815	PLCB1/ADCY9/PRKAA2/PLCB4	0.618001430637207
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	6/198	227/9376	1.25163529568816	PLCB1/ADCY9/PLCB4/EGFR/IL6R/PTK2	0.563692009901662
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	3/198	99/9376	1.4349556167738	MAPK10/DGKH/EGFR	0.639003105950423
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	4/198	142/9376	1.33390240432494	MAPK10/PRKAA2/BMPR1B/PTK2	0.588861268297866
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	3/198	100/9376	1.42060606060606	CD36/IL5RA/IL6R	0.621068299942365
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	2/198	59/9376	1.60520458825544	AK9/NME7	0.684911371205186
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	2/198	59/9376	1.60520458825544	EGFR/TCF7L2	0.684911371205186
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/198	22/9376	2.1524334251607	MAOA	0.794827180846653
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	2/198	62/9376	1.52753339850114	MAML2/TLE4	0.612099317033634
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/198	63/9376	1.50328683662017	FZD3/TCF7L2	0.588688092772732
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	5/198	193/9376	1.22677552729366	PLCB1/ADCY9/PLCB4/TIAM1/PTK2	0.467548593020725
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/198	23/9376	2.05884936319719	CRPPA	0.746735566985226
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	2/198	65/9376	1.45703185703186	DGKH/MOGAT1	0.543061725158553
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	2/198	65/9376	1.45703185703186	PLCB1/PLCB4	0.543061725158553
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	4/198	154/9376	1.22996195723468	UGT2B7/AK9/IDO2/NME7	0.422618013643753
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	3/198	110/9376	1.29146005509642	EGFR/IGF1R/IL6R	0.451620288614214
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	5/198	200/9376	1.18383838383838	MAPK10/ACTR3C/MYH14/MYO1E/TJP1	0.385983460495245
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/198	68/9376	1.39275103980986	CYP26A1/UGT2B7	0.477405940995643
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	2/198	68/9376	1.39275103980986	PER2/TCF7L2	0.477405940995643
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	6/198	248/9376	1.14565004887586	MAPK10/ACTR3C/DYNC2H1/AHNAK/TCF7L2/AHNAK2	0.341423072324057
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	2/198	69/9376	1.37256624213146	MAOA/SLC18A2	0.456212726733982
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	3/198	115/9376	1.23530961791831	PLCB1/ADCY9/PLCB4	0.372909857268126
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/198	28/9376	1.69119769119769	GCNT2	0.537980023133659
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/198	28/9376	1.69119769119769	MOCOS	0.537980023133659
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/198	28/9376	1.69119769119769	ATP6V1C2	0.537980023133659
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/198	73/9376	1.29735713297357	MAOA/UGT2B7	0.374604066046885
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	2/198	73/9376	1.29735713297357	SERINC5/MLLT1	0.374604066046885
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	3/198	119/9376	1.19378660555131	RPS6KA5/MAPK10/CFLAR	0.312468549207969
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/198	30/9376	1.57845117845118	ALOX15	0.466078055988356
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	2/198	76/9376	1.2461456671983	ACSL5/CD36	0.316447540056279
Human Diseases	Cancer: specific types	hsa05214	Glioma	2/198	76/9376	1.2461456671983	EGFR/IGF1R	0.316447540056279
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	5/198	216/9376	1.09614665170221	MAPK10/PLCB1/CD36/PLCB4/PTK2	0.209970126541831
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/198	31/9376	1.52753339850114	UGT2B7	0.432101089191122
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/198	31/9376	1.52753339850114	PCCA	0.432101089191122
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/198	31/9376	1.52753339850114	IMMP2L	0.432101089191122
NA	NA	hsa04382	Cornified envelope formation	5/198	217/9376	1.09109528464367	DST/LAMA3/DSP/TJP1/LAMB3	0.199409544416367
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	2/198	77/9376	1.22996195723468	MAPK10/EGFR	0.297596241315823
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	2/198	78/9376	1.21419321419321	MAPK10/C3	0.278998870450961
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/198	32/9376	1.47979797979798	PCCA	0.399310928181563
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/198	32/9376	1.47979797979798	MAPK10	0.399310928181563
Organismal Systems	Immune system	hsa04611	Platelet activation	3/198	126/9376	1.12746512746513	PLCB1/ADCY9/PLCB4	0.211568008210439
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/198	33/9376	1.4349556167738	STX18	0.367623229239177
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	2/198	82/9376	1.1549642769155	UGT2B7/NME7	0.207005265666145
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	2/198	83/9376	1.1410490446635	UBE2D2/MBD5	0.1895725418372
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/198	36/9376	1.31537598204265	GALNT13	0.278452187989391
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/198	86/9376	1.10124500822175	PLCB1/PLCB4	0.138534899906599
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/198	37/9376	1.27982527982528	RIMKLB	0.250485059951028
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	1/198	37/9376	1.27982527982528	TCF7L2	0.250485059951028
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/198	38/9376	1.2461456671983	HSD11B2	0.223306449065938
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	3/198	138/9376	1.02942468159859	MAPK10/FOXO1/PRKAA2	0.0511453956987809
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	2/198	89/9376	1.06412438996709	GABRG3/ADCY9	0.0892739464762788
Organismal Systems	Digestive system	hsa04976	Bile secretion	2/198	90/9376	1.05230078563412	ADCY9/UGT2B7	0.0732249922449979
Human Diseases	Substance dependence	hsa05032	Morphine addiction	2/198	91/9376	1.04073704073704	GABRG3/ADCY9	0.0573539622455829
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	3/198	142/9376	1.0004268032437	MAPK10/TEC1/ATP2A2	0.000752698681249865
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/198	41/9376	1.1549642769155	MAOA	0.146053028913191
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/198	41/9376	1.1549642769155	GABRG3	0.146053028913191
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	2/198	93/9376	1.01835559900076	MAPK10/MAML2	0.0261282346188691
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	4/198	195/9376	0.971354571354571	PLCB1/HDAC9/PLCB4/C3	-0.0593706555091401
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/198	43/9376	1.10124500822175	ACSL5	0.0977330430918042
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/198	43/9376	1.10124500822175	CD36	0.0977330430918042
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	2/198	99/9376	0.956637077849199	DEFB1/C3	-0.0637054468751888
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/198	46/9376	1.02942468159859	UGT2B7	0.0293828604637101
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	2/198	100/9376	0.947070707070707	IL20RA/IL6R	-0.0781555689648894
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/198	47/9376	1.00752202879862	MAPK10	0.00759295071444907
NA	NA	hsa03272	Virion - Hepatitis viruses	1/198	48/9376	0.986531986531986	EGFR	-0.0137396002948298
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	2/198	103/9376	0.919486123369618	COL28A1/SLC3A1	-0.120676700386407
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	2/198	104/9376	0.910644910644911	SGMS2/DGKH	-0.134584008166891
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	1/198	49/9376	0.966398680684395	GALNT13	-0.0346359886026518
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	2/198	105/9376	0.901972101972102	MAPK10/TFEB	-0.148362880267607
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/198	50/9376	0.947070707070707	MAOA	-0.0551159878396461
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	1/198	52/9376	0.910644910644911	CD36	-0.0948995251818923
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	2/198	109/9376	0.86887220832175	MAPK10/IL6R	-0.202247248279556
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	2/198	110/9376	0.860973370064279	THSD4/BMPR1B	-0.215423162243831
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/198	54/9376	0.876917321361766	REV3L	-0.133224309034422
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	1/198	55/9376	0.860973370064279	SGMS2	-0.151877098901572
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	3/198	168/9376	0.845598845598846	MAPK10/ALOX15/CFLAR	-0.296596987253423
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	1/198	56/9376	0.845598845598846	BOC	-0.170208328588763
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	1/198	56/9376	0.845598845598846	C3	-0.170208328588763
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/198	57/9376	0.830763778132199	ACSL5	-0.188230631789648
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1/198	59/9376	0.802602294127718	ADCY9	-0.223395420367632
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	1/198	60/9376	0.789225589225589	PTK2	-0.240559756674485
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	2/198	122/9376	0.776287464812055	MAPK10/TEC1	-0.365300018175698
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/198	63/9376	0.751643418310085	MECOM	-0.290499476172336
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/198	63/9376	0.751643418310085	ALOX15	-0.290499476172336
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	4/198	238/9376	0.795857737034207	MAPK10/EGFR/C3/IL6R	-0.468532836282708
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	3/198	187/9376	0.759682385350835	MAPK10/PLCB1/PLCB4	-0.487547000350008
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	1/198	69/9376	0.68628312106573	MAPK10	-0.384150834338281
Human Diseases	Substance dependence	hsa05034	Alcoholism	3/198	191/9376	0.743772806600032	HDAC9/MAOA/SLC18A2	-0.525468309782973
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/198	70/9376	0.676479076479077	UGT2B7	-0.399037835632937
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	1/198	70/9376	0.676479076479077	MET	-0.399037835632937
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	4/198	250/9376	0.757656565656566	ATP6V1C2/TFEB/OSBPL6/DEPTOR	-0.570433781611734
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/198	72/9376	0.657687991021324	MAPK10	-0.428250362561944
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	3/198	196/9376	0.724799010513296	MAPK10/TCF7L2/C3	-0.571874712140306
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	2/198	137/9376	0.691292486912925	MAPK10/CFLAR	-0.534612619222422
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	6/198	370/9376	0.767895167895168	GABRG3/GRIK2/THRB/GRM5/RXFP1/C3	-0.669057247225365
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	1/198	75/9376	0.631380471380471	REV3L	-0.470747861270278
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	2/198	142/9376	0.66695120216247	UBE2D2/MID1	-0.587355870935366
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	1/198	77/9376	0.614980978617342	MECOM	-0.498257255140868
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	1/198	78/9376	0.607096607096607	PABPC4L	-0.511779064660348
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	1/198	78/9376	0.607096607096607	C3	-0.511779064660348
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	3/198	205/9376	0.692978566149298	SCIN/HDAC9/C3	-0.652802014662966
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/198	79/9376	0.599411839918169	UGT2B7	-0.525151301091562
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	5/198	323/9376	0.733026863057823	RPS6KA5/MET/EGFR/FOXP1/FZD3	-0.717161178345596
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	1/198	83/9376	0.570524522331751	ACSL5	-0.577223037224744
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	1/198	83/9376	0.570524522331751	ZDHHC11B	-0.577223037224744
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	2/198	156/9376	0.607096607096607	EGFR/CFLAR	-0.726819924901352
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	1/198	88/9376	0.538108356290175	C3	-0.639388093435906
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	1/198	90/9376	0.526150392817059	EGFR	-0.663424715146741
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	1/198	94/9376	0.503761014399312	MAPK10	-0.710196016148977
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	1/198	95/9376	0.498458266879319	ATP6V1C2	-0.72163186047958
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	4/198	298/9376	0.635617924208528	IL5RA/IL20RA/BMPR1B/IL6R	-0.938889008988401
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	2/198	174/9376	0.544293509810751	MAPK10/UBE2D2	-0.891174867422839
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	1/198	103/9376	0.459743061684809	PABPC4L	-0.809753888463719
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	1/198	105/9376	0.450986050986051	CFLAR	-0.830919487426136
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	1/198	105/9376	0.450986050986051	MAPK10	-0.830919487426136
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	2/198	181/9376	0.523243484569451	MAPK10/C3	-0.951271015209397
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	1/198	109/9376	0.434436104160875	MAPK10	-0.872307389576066
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	1/198	116/9376	0.408220132358063	PCCA	-0.941950095084088
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	1/198	117/9376	0.404731071397738	BAZ2B	-0.95163040535465
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	2/198	214/9376	0.442556405173228	MAPK10/PTK2	-1.21159334523353
Human Diseases	Infectious disease: viral	hsa05162	Measles	1/198	136/9376	0.348187759952466	MAPK10	-1.1246054577508
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	2/198	224/9376	0.422799422799423	MAPK10/ADCY9	-1.28421271871195
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	1/198	143/9376	0.331143603870877	C3	-1.18378734269735
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	1/198	157/9376	0.301614874863283	FOXO1	-1.29612565259551
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	1/198	158/9376	0.299705919959085	CDC14A	-1.30387168207335
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	1/198	163/9376	0.290512486831505	MAPK10	-1.34209182086347
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	1/198	180/9376	0.26307519640853	C3	-1.466236924633
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	1/198	205/9376	0.230992855383099	MAPK10	-1.63509565765446