category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	91/1097	222/9376	3.50347795379701	RPS10/RPS8/RPL6/RACK1/RPSA/RPS24/RPS26/RPS6/RPL19/RPL10/RPL17/RPL27A/RPL26/RPL5/RPS3A/RPS12/RPS27A/RPL13A/RPL13/RPL14/RPL10A/RPL7A/RPL30/RPS4X/RPL12/RPS3/RPL32/RPL3/RPL41/RPL15/RPL36A/RPS15/RPL8/RPL36AL/RPS9/RPS5/RPS15A/RPL22/RPS13/MRPS34/MRPL12/MRPL2/RPL24/RPS23/RPL11/RPL21/MRPS15/RPS16/MRPS18B/RPS2/RPS25/RPL35A/RPS7/MRPL34/MRPS18A/MRPL15/RPS18/MRPL14/MRPL16/RPL22L1/RPL9/RPS19/MRPS33/MRPS7/RPLP1/FAU/MRPS24/RPL31/RPLP0/MRPS35/MRPL52/MRPS2/MRPL28/RPL4/MRPL36/RPS20/MRPL10/MRPS12/UBA52/MRPL48/RPL23A/RPL28/MRPL13/MRPS10/MRPL46/MRPL18/MRPS21/MRPL41/MRPL33/RSL24D1/MRPL53	13.7408884862427
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	84/1097	268/9376	2.67889359038898	MT-ND2/RPS27A/MT-ATP8/BAX/COX4I1/NDUFB7/UQCRH/SLC25A6/PARK7/MT-ND6/ATP5MC3/PSMD4/NDUFB11/NDUFS3/PSMC3/CYCS/MT-ND1/COX8A/MT-ND4/COX6B1/SLC25A5/COX6A1/ATP5PD/COX7A1/NDUFB9/NDUFA11/PSMD7/ATP5F1D/NDUFS7/ATP5MC2/NDUFS2/SLC39A4/VDAC1/NDUFA3/NDUFB2/NDUFS8/PSMD2/SLC39A3/SLC39A1/NDUFB5/PSMC5/SLC39A7/ATP5PO/ATP5MC1/PSMD8/PSMD13/VDAC2/UQCRC1/COX5A/NDUFA6/NDUFV3/PSMB6/UQCRFS1/PSMD6/PSMC6/PSMD12/PSMA5/SOD1/UBA52/NDUFA4/NDUFB10/PINK1/ATF4/NDUFA13/NDUFS6/UBC/TUBA1B/TUBA1A/COX5B/TH/TUBB2A/UQCR11/TXN/HTRA2/PSMA7/CYC1/NDUFAB1/CALM1/XBP1/ATP5F1C/NDUFS5/GNAL/MAP3K5/SLC25A4	10.150304428155
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	90/1097	308/9376	2.49748428417526	MT-ND2/MT-ATP8/BAX/COX4I1/GRIA4/NDUFB7/UQCRH/SLC25A6/MT-ND6/ATP5MC3/PSMD4/NDUFB11/NDUFS3/PSMC3/CYCS/MT-ND1/COX8A/MT-ND4/COX6B1/GPX7/SLC25A5/COX6A1/ATP5PD/POLR2C/COX7A1/NDUFB9/NDUFA11/PSMD7/ATP5F1D/NDUFS7/ATP5MC2/NDUFS2/VDAC1/TFAM/NDUFA3/NDUFB2/NDUFS8/PSMD2/POLR2F/NDUFB5/PSMC5/POLR2E/ATP5PO/ATP5MC1/PSMD8/PSMD13/VDAC2/NRBF2/UQCRC1/COX5A/NDUFA6/NDUFV3/POLR2G/PSMB6/UQCRFS1/PSMD6/PSMC6/CLTA/ATG101/PSMD12/PSMA5/SOD1/NDUFA4/NDUFB10/NDUFA13/POLR2J/CREB3/NDUFS6/TUBA1B/TUBA1A/POLR2I/COX5B/TUBB2A/UQCR11/DNAL4/PSMA7/CYC1/NDUFAB1/AP2S1/AP2M1/POLR2L/ATP5F1C/NDUFS5/DLG4/PLCB2/BBC3/TRAF2/MAP3K5/SLC25A4/HAP1	9.72706653308279
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	51/1097	138/9376	3.15865403670088	MT-ND2/MT-ATP8/COX4I1/NDUFB7/UQCRH/MT-ND6/ATP5MC3/NDUFB11/NDUFS3/ATP6V0D1/CYCS/MT-ND1/COX8A/MT-ND4/COX6B1/COX6A1/ATP5PD/COX7A1/NDUFB9/NDUFA11/ATP5F1D/ATP6V0C/NDUFS7/ATP5MC2/NDUFS2/NDUFA3/NDUFB2/NDUFS8/NDUFB5/ATP5PO/ATP5MC1/UQCRC1/COX5A/NDUFA6/NDUFV3/COX11/UQCRFS1/ATP6V1F/NDUFA4/NDUFB10/NDUFA13/NDUFS6/COX5B/UQCR11/CYC1/NDUFAB1/ATP5F1C/ATP6V1E2/ATP6V1B2/NDUFS5/ATP6V1G2	9.29894372157106
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	69/1097	227/9376	2.59797043599083	MT-ND2/MT-ATP8/EPHX1/COX4I1/GSTM3/NDUFB7/CYP1B1/UQCRH/GSTM5/MAP2K2/SLC25A6/MT-ND6/JUN/ATP5MC3/NDUFB11/NDUFS3/BAD/MT-ND1/COX8A/AKR1A1/MT-ND4/COX6B1/SLC25A5/CBR1/COX6A1/ATP5PD/CYBA/COX7A1/NDUFB9/NDUFA11/ATP5F1D/NDUFS7/ATP5MC2/NDUFS2/VDAC1/NDUFA3/NDUFB2/NDUFS8/ACP1/NDUFB5/ATP5PO/HRAS/ATP5MC1/VDAC2/UQCRC1/COX5A/NDUFA6/NDUFV3/UQCRFS1/MAPK12/SOD1/NDUFA4/NDUFB10/NDUFA13/NDUFS6/COX5B/GSTO1/UQCR11/GSTM1/CYC1/NDUFAB1/GSTM4/ATP5F1C/NDUFS5/MAP3K5/GSTM2/SLC25A4/AS3MT/PLD1	8.87145523938885
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	71/1097	238/9376	2.54971924959592	RPS10/RPS8/RPL6/RPSA/RPS24/RPS26/RPS6/RPL19/RPL10/RPL17/RPL27A/RPL26/RPL5/RPS3A/RPS12/RPS27A/RPL13A/RPL13/RPL14/RPL10A/RPL7A/RPL30/RPS4X/RPL12/RPS3/RPL32/RPL3/RPL41/RPL15/RPL36A/RPS15/RPL8/RPL36AL/JUN/RPS9/RPS5/NFKBIB/RPS15A/RPL22/RPS13/RPL24/RPS23/RPL11/RPL21/PLCG2/RPS16/RPS2/RPS25/RPL35A/RPS7/RPS18/RPL22L1/RPL9/RPS19/RPLP1/FAU/C2/RPL31/RPLP0/RPL4/RPS20/MAPK12/UBA52/RPL23A/RPL28/CGAS/IRAK1/RSL24D1/C6/C3/CFD	8.81487057157562
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	77/1097	275/9376	2.39314494074749	MT-ND2/MT-ATP8/BAX/COX4I1/NDUFB7/UQCRH/SLC25A6/MT-ND6/ATP5MC3/PSMD4/NDUFB11/NDUFS3/BAD/PSMC3/CYCS/MT-ND1/COX8A/MT-ND4/COX6B1/SLC25A5/COX6A1/ATP5PD/CYBA/COX7A1/NDUFB9/NDUFA11/PSMD7/ATP5F1D/HSPA8/NDUFS7/ATP5MC2/NDUFS2/VDAC1/NDUFA3/NDUFB2/NDUFS8/PSMD2/NDUFB5/PSMC5/ATP5PO/ATP5MC1/PSMD8/PSMD13/VDAC2/UQCRC1/COX5A/NDUFA6/NDUFV3/PSMB6/UQCRFS1/PSMD6/PSMC6/PSMD12/MAPK12/PSMA5/SOD1/NDUFA4/NDUFB10/ATF4/NDUFA13/CREB3/NDUFS6/TUBA1B/TUBA1A/COX5B/TUBB2A/UQCR11/CAV2/PSMA7/CYC1/NDUFAB1/NCAM2/ATP5F1C/NDUFS5/NOTCH1/SLC25A4/C6	8.53528648227699
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	96/1097	388/9376	2.11470834233946	MT-ND2/GAPDH/MT-ATP8/COX4I1/WNT2/NDUFB7/UQCRH/MAP2K2/SLC25A6/MT-ND6/ATP5MC3/PSMD4/NDUFB11/NDUFS3/BAD/PSMC3/CYCS/MT-ND1/COX8A/MT-ND4/COX6B1/SLC25A5/COX6A1/ATP5PD/COX7A1/NDUFB9/NDUFA11/PSMD7/ATP5F1D/NDUFS7/ATP5MC2/NDUFS2/SLC39A4/VDAC1/NDUFA3/PSENEN/NDUFB2/NDUFS8/PSMD2/SLC39A3/SLC39A1/NDUFB5/PSMC5/SLC39A7/ATP5PO/HRAS/ATP5MC1/PSMD8/PSMD13/VDAC2/NRBF2/UQCRC1/COX5A/NDUFA6/NDUFV3/PSMB6/HSD17B10/UQCRFS1/PSMD6/PSMC6/PPID/ATG101/PSMD12/PSMA5/NDUFA4/NDUFB10/FRAT2/ATF4/NDUFA13/NDUFS6/TUBA1B/TUBA1A/COX5B/WNT5A/BACE2/TUBB2A/UQCR11/BID/PSMA7/CYC1/NDUFAB1/CDK5/CALM1/LRP5/XBP1/ATP5F1C/NDUFS5/PLCB2/WNT2B/TRAF2/MAP3K5/SLC25A4/FZD10/PSEN2/LPL/ATP2A1	8.162920990666
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	111/1097	480/9376	1.97648131267092	MT-ND2/RPS27A/MT-ATP8/BAX/COX4I1/GRIA4/WNT2/NDUFB7/UQCRH/MAP2K2/SLC25A6/PARK7/MT-ND6/ATP5MC3/PSMD4/NDUFB11/NDUFS3/BAD/PSMC3/TOMM40/CYCS/MT-ND1/COX8A/MT-ND4/COX6B1/GPX7/SLC25A5/COX6A1/ATP5PD/COX7A1/NDUFB9/NDUFA11/PSMD7/ATP5F1D/NDUFS7/ATP5MC2/NDUFS2/SIGMAR1/VDAC1/NDUFA3/NDUFB2/NDUFS8/PSMD2/NDUFB5/NEFM/PSMC5/ATP5PO/HRAS/ATP5MC1/PSMD8/PSMD13/VDAC2/NRBF2/UQCRC1/COX5A/NDUFA6/NDUFV3/PSMB6/HSD17B10/UQCRFS1/PSMD6/PSMC6/NEFH/PPID/ATG101/PSMD12/MAPK12/PSMA5/SOD1/UBA52/NDUFA4/NDUFB10/PINK1/FRAT2/BAK1/MAP1LC3B/ATF4/NDUFA13/NDUFS6/UBC/TUBA1B/TUBA1A/COX5B/WNT5A/TUBB2A/UQCR11/DNAL4/BID/HTRA2/PSMA7/CYC1/NDUFAB1/CDK5/CALM1/LRP5/XBP1/ATP5F1C/NDUFS5/DLG4/PLCB2/SQSTM1/WNT2B/TRAF2/MAP3K5/SLC25A4/FZD10/PSEN2/ATP2A1/SPTBN2/HAP1/TOMM40L	7.99442400905472
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	92/1097	368/9376	2.13673655423883	MT-ND2/MT-ATP8/HNRNPA1/BAX/COX4I1/NDUFB7/UQCRH/MT-ND6/ATP5MC3/PSMD4/CHCHD10/NDUFB11/NDUFS3/BAD/PSMC3/TOMM40/CYCS/MT-ND1/COX8A/MT-ND4/COX6B1/GPX7/COX6A1/ATP5PD/COX7A1/NDUFB9/NDUFA11/PSMD7/ATP5F1D/NDUFS7/ATP5MC2/ANXA11/NDUFS2/SIGMAR1/VDAC1/NDUFA3/NDUFB2/NDUFS8/PSMD2/NDUFB5/NEFM/PSMC5/ATP5PO/ATP5MC1/PSMD8/PSMD13/NRBF2/UQCRC1/COX5A/NDUFA6/NDUFV3/PSMB6/UQCRFS1/PSMD6/PSMC6/NEFH/ATG101/PSMD12/MAPK12/PSMA5/SOD1/NDUFA4/NDUFB10/PINK1/MAP1LC3B/ATF4/NDUFA13/NDUFS6/TUBA1B/TPR/RAE1/TUBA1A/COX5B/TUBB2A/UQCR11/DNAL4/BID/SRSF3/PSMA7/CYC1/NDUFAB1/XBP1/ATP5F1C/NDUFS5/NUP210L/NRG2/SQSTM1/TRAF2/MAP3K5/HNRNPA1L2/HAP1/TOMM40L	8.09784681706586
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	59/1097	205/9376	2.45985281366031	MT-ND2/GAPDH/MT-ATP8/COX4I1/NDUFB7/UQCRH/SLC25A6/MT-ND6/ATP5MC3/NDUFB11/NDUFS3/MT-ND1/COX8A/MT-ND4/COX6B1/PARP1/SLC25A5/COX6A1/ATP5PD/CYBA/PDHA1/COX7A1/NDUFB9/NDUFA11/ATP5F1D/NDUFS7/ATP5MC2/NDUFS2/VDAC1/NDUFA3/NDUFB2/NDUFS8/NDUFB5/CTSD/ATP5PO/ATP5MC1/VDAC2/PDHB/UQCRC1/COX5A/NDUFA6/NDUFV3/UQCRFS1/MAPK12/NDUFA4/NDUFB10/NDUFA13/NDUFS6/COX5B/UQCR11/TGFB2/PRKCZ/CYC1/NDUFAB1/ATP5F1C/NDUFS5/PLCB2/SLC25A4/ATP2A1	7.69267997691294
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	62/1097	235/9376	2.25493900192013	MT-ND2/RPS6/MT-ATP8/MGLL/COX4I1/NDUFB7/UQCRH/MT-ND6/ATP5MC3/RPS6KB2/NDUFB11/NDUFS3/MT-ND1/COX8A/SMARCB1/MT-ND4/COX6B1/COX6A1/ATP5PD/COX7A1/NDUFB9/NDUFA11/ATP5F1D/NDUFAF8/NDUFS7/ATP5MC2/NDUFS2/NDUFA3/NDUFB2/NDUFS8/SMARCD3/COA6/NDUFB5/ATP5PO/COX14/HRAS/ATP5MC1/UQCRC1/COX5A/NDUFA6/NDUFV3/COX11/UQCRFS1/MAPK12/MLST8/NDUFA4/NDUFAF3/NDUFB10/NDUFA13/CREB3/NDUFS6/COX5B/NDUFAF2/UQCR11/CYC1/NDUFAB1/FGFR1/ATP5F1C/NDUFS5/MAP3K5/DPF1/ADCY2	7.09185266080197
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	42/1097	157/9376	2.28644421090525	BAX/COX4I1/NDUFB7/UQCRH/JUN/NDUFB11/NDUFS3/CYCS/COX8A/COX6B1/COX6A1/COX7A1/NDUFB9/NDUFA11/NDUFS7/NDUFS2/NDUFA3/NDUFB2/NDUFS8/NDUFB5/UQCRC1/COX5A/NDUFA6/NDUFV3/UQCRFS1/MAPK12/NDUFA4/NDUFB10/ATF4/NDUFA13/NDUFS6/COX5B/UQCR11/BID/CYC1/NDUFAB1/XBP1/NDUFS5/SOCS3/TRAF2/MAP3K5/BCL2L11	5.91696344695723
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	18/1097	63/9376	2.44198463341581	ERCC1/POLE4/XPA/POLD2/POLR2C/RAD23A/XPC/POLR2F/POLR2E/POLR2G/POLE3/ERCC4/POLR2J/POLR2I/RFC2/POLR2L/RFC3/RFC4	4.18009465614075
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	12/1097	34/9376	3.01656925304306	POLR2C/POLR1E/POLR2F/POLR2E/POLR3K/POLR2G/POLR3GL/POLR2J/POLR3D/POLR2I/POLR2L/POLR3B	4.28778182322532
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	17/1097	59/9376	2.46267941844476	GSTM3/GSTM5/GSTP1/SRM/GPX4/GPX7/GGCT/PRDX6/GSTK1/GSS/SMS/GSTO1/GSTM1/GSTM4/GCLC/GGT5/GSTM2	4.10239164665592
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	35/1097	174/9376	1.71921331950251	ERP29/HSP90AB1/BAX/SSR2/BAG1/DAD1/UBXN1/UFD1/SSR4/BCAP31/HSPA8/STUB1/RAD23A/KRTCAP2/ERLEC1/DNAJB11/BAG2/DNAJB12/PDIA6/SSR3/RNF5/UBXN4/BAK1/HSPBP1/ATF4/DDOST/PPP1R15A/HERPUD1/DNAJA1/UBE2D4/XBP1/DNAJB1/TRAF2/MAP3K5/TRAM1L1	3.48570991771166
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	15/1097	54/9376	2.37415172693204	LDHA/SRM/LDHB/MDH2/CISD1/GSS/BHMT2/CDO1/MRI1/MDH1/SMS/BHMT/TST/GCLC/PHGDH	3.68618416611594
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	13/1097	46/9376	2.41544132218303	PSMD4/PSMC3/PSMD7/PSMD2/PSMC5/PSMD8/PSMD13/PSMB6/PSMD6/PSMC6/PSMD12/PSMA5/PSMA7	3.50291803087357
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	30/1097	149/9376	1.72086165442054	MT-ND2/MGLL/GRIA4/NDUFB7/MT-ND6/NDUFB11/NDUFS3/MT-ND1/MT-ND4/NDUFB9/NDUFA11/NDUFS7/NDUFS2/NDUFA3/NDUFB2/NDUFS8/NDUFB5/NDUFA6/NDUFV3/MAPK12/NDUFA4/NDUFB10/NDUFA13/NDUFS6/GNG4/NDUFAB1/NDUFS5/PLCB2/GNAO1/ADCY2	3.22860421068859
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	18/1097	75/9376	2.05126709206928	BAX/GSTM3/GSTM5/GSTP1/ERCC1/BAD/CYCS/XPA/PMAIP1/BAK1/GSTO1/BID/GSTM1/CDKN2A/GSTM4/BBC3/MAP3K5/GSTM2	3.32719986746505
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	29/1097	144/9376	1.72126000202573	SLC25A6/PSMD4/PSMC3/CYCS/SLC25A5/NOP56/PSMD7/VDAC1/PSMD2/PSMC5/PSMD8/PSMD13/KCND3/VDAC2/NRBF2/PSMB6/PSMD6/PSMC6/ATG101/PSMD12/PSMA5/PSMA7/XBP1/PLCB2/TRAF2/MAP3K5/SLC25A4/ATP2A1/SPTBN2	3.17486459367009
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	10/1097	32/9376	2.67092069279854	BAX/NGFR/CYCS/PMAIP1/BOK/BAK1/BID/HTRA2/BBC3/BCL2L11	3.44639000696373
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	12/1097	44/9376	2.33098533189691	POLE4/TDG/PARP1/POLD2/NTHL1/POLE3/MBD4/RFC2/RFC3/NEIL1/RFC4/FEN1	3.22115967220078
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	16/1097	67/9376	2.04106178315351	GAPDH/TPI1/LDHA/AKR1A1/LDHB/PGAM1/PDHA1/PGM2/PDHB/ALDOA/G6PC3/ENO1/ADH1C/ALDH1B1/PGM1/BPGM	3.11288015600399
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	11/1097	41/9376	2.29308313137826	GCSH/PGAM1/GRHPR/GAMT/SRR/BHMT/PHGDH/AMT/ALAS1/BPGM/CHDH	3.0203774846237
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	29/1097	154/9376	1.60948987202406	NME1/AKR1A1/MOCS2/PPCS/GUSB/NME4/VKORC1/ADSL/HMBS/GSS/AK6/PMM1/QPRT/COQ4/COASY/AK1/NME6/DHODH/MTHFD1L/RFK/ALDH1B1/COQ7/RDH13/OXSM/GCLC/DHRS3/ALAS1/PHOSPHO2/SPR	2.77596704104732
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	10/1097	36/9376	2.37415172693204	POLE4/POLD2/RNASEH2C/POLE3/RFC2/RFC3/DNA2/RFC4/FEN1/RNASEH2A	3.00685517575774
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	26/1097	137/9376	1.62204818715941	CTSH/CTSF/BAX/MAP2K2/JUN/CTSZ/BAD/CYCS/GADD45A/PARP1/CTSD/HRAS/CTSK/PMAIP1/BAK1/ATF4/TUBA1B/TUBA1A/BID/HTRA2/NTRK1/BBC3/TRAF2/MAP3K5/BCL2L11/NGF	2.66975764903255
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	42/1097	250/9376	1.4358869644485	CTSH/CTSF/CTSZ/AP1S1/ATP6V0D1/GNPTG/BORCS7/LAPTM4B/ASAH1/KXD1/ATP6V0C/GUSB/CD63/ACP2/CTSD/CTSK/ATP6V1F/CLTA/LAMTOR4/MLST8/DNASE2/IDUA/PPT1/GLA/LAMTOR2/ROGDI/LAPTM4A/AGA/AP2S1/AP2M1/GPR155/AP4M1/ATP6V1E2/ATP6V1B2/AP5S1/SLC29A3/BORCS6/GALNS/NPC2/ATP6V1G2/DEPTOR/FUCA1	2.5427500064932
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	13/1097	56/9376	1.98411251465034	DAD1/B4GALT2/KRTCAP2/DPM2/DPM3/ALG3/ALG12/ALG14/ALG5/SRD5A3/DDOST/DOLK/ALG6	2.68862865301305
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	30/1097	170/9376	1.50828462652153	BAX/WNT2/GSTM3/GSTM5/MAP2K2/RPS6KB2/GSTP1/IGF2/BAD/GADD45A/SMARCB1/PLCG2/SMARCD3/HRAS/CDK4/FRAT2/BAK1/WNT5A/GSTO1/TGFB2/GSTM1/CDKN2A/GSTM4/LRP5/TXNRD3/SHC3/WNT2B/GSTM2/FZD10/DPF1	2.43442253983668
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	22/1097	116/9376	1.62097255838808	GAPDH/TKT/TPI1/GCSH/PGP/PGAM1/PDHA1/MDH2/IDH3B/PDHB/SUCLA2/ALDOA/ECHS1/ENO1/ACADS/MDH1/SUCLG1/MCEE/IDH3G/PHGDH/AMT/TKFC	2.44960421425405
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	11/1097	47/9376	2.00034911460657	LDHA/AKR1A1/LDHB/PDHA1/MDH2/GRHPR/PDHB/ADH1C/MDH1/ALDH1B1/HAGH	2.50255127884014
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	17/1097	85/9376	1.70938924339107	NME1/DCTPP1/ASMTL/APRT/NME4/DTYMK/ADSL/HPRT1/AK6/AK1/HDDC2/NT5C/NME6/IMPDH1/NT5M/ENTPD2/NUDT16	2.39145846490594
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	20/1097	105/9376	1.62798975561054	RPS27A/FKBP8/JUN/PHB2/TOMM40/CITED2/FIS1/HRAS/SAMM50/UBA52/PINK1/RRAS/MAP1LC3B/ATF4/UBC/GABARAPL2/MRAS/SQSTM1/TRAF2/TOMM40L	2.3555044489213
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	8/1097	30/9376	2.27918565785476	PDHA1/MDH2/IDH3B/PDHB/SUCLA2/MDH1/SUCLG1/IDH3G	2.55435545021277
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	22/1097	120/9376	1.56694013977514	BAX/MAP2K2/NGFR/JUN/NFKBIB/BAD/PLCG2/HRAS/MAPK12/YWHAE/ATF4/IRAK1/CALM1/BEX3/NTRK1/SHC3/RAP1B/ZNF274/MAP3K5/NFKBIE/PSEN2/NGF	2.27518212586812
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	17/1097	87/9376	1.67009293894529	COX4I1/UQCRH/TPM1/COX8A/COX6B1/TPM4/COX6A1/COX7A1/UQCRC1/COX5A/TPM2/UQCRFS1/COX5B/UQCR11/CYC1/MYL3/ATP2A1	2.28565246955172
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	8/1097	31/9376	2.20566353985944	GCSH/PGP/MDH2/HYI/GRHPR/MDH1/MCEE/AMT	2.44746974843902
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	23/1097	128/9376	1.53577939835916	NME1/APRT/NME4/PGM2/ADPRM/ADSL/HPRT1/AK6/NUDT9/PDE4D/AK1/HDDC2/NT5C/NME6/GUCY1A1/IMPDH1/NT5M/PGM1/ENTPD2/NUDT16/HDDC3/GUCY1B1/ADCY2	2.22160628408384
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	8/1097	32/9376	2.13673655423883	LDHA/LDHB/SUCLA2/ECHS1/ACADS/SUCLG1/MCEE/MLYCD	2.344598111666
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	9/1097	42/9376	1.83148847506186	GPX4/SAT2/GSS/VDAC2/MAP1LC3B/SLC3A2/FTH1/GCLC/SLC7A11	1.96583467674268
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	14/1097	75/9376	1.59542996049833	BAX/CYCS/GADD45A/CDK4/PMAIP1/ZNF385A/BID/CDKN2A/GORAB/CHEK2/CDK2/THBS1/BBC3/CDK1	1.88450157015302
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	19/1097	110/9376	1.47629071020138	RPS6/GAPDH/MAP2K2/LDHA/RPS6KB2/EGLN3/LDHB/LTBR/PLCG2/PDHA1/EIF4EBP1/TIMP1/PDHB/ALDOA/ENO1/EIF4E2/ELOB/ELOC/ANGPT1	1.82903626399737
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	32/1097	205/9376	1.33415745825644	BAX/JUN/NFKBIB/PSMD4/PSMC3/CYCS/GADD45A/SNW1/PLCG2/PSMD7/VIM/PSMD2/PSMC5/TAPBPL/PSMD8/PSMD13/CDK4/PSMD6/PSMC6/PSMD12/MAPK12/BAK1/SAP30/BID/IRAK1/RELB/NFKB2/CDK2/TRAF2/NFKBIE/BCL2L11/HLA-DQB1	1.76083942450351
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	7/1097	30/9376	1.99428745062291	GPAA1/PIGQ/DPM2/PIGX/PIGC/PIGH/PIGZ	1.98545344296314
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	11/1097	57/9376	1.64941067344752	HSD17B12/ACADVL/ACAA2/TECR/ECHS1/PPT1/ACADS/ACSF3/MCAT/OXSM/HSD17B8	1.79007902947646
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	14/1097	78/9376	1.53406726970993	ARPC5/ARPC5L/MAD2L2/SEPTIN1/ACTR3B/ARPC1B/CLTA/ARPC3/CAV2/DNM3/SEPTIN6/SHC3/ARPC2/ARHGEF26	1.72404463019532
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	12/1097	65/9376	1.57789776313022	MGLL/AKR1A1/AGPAT2/LPIN3/GLA/PLPP4/ALDH1B1/DGKA/TKFC/GPAT2/PLPP2/LPL	1.7018039961804
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	7/1097	32/9376	1.86964448495898	B4GALT2/PGM2/GALK1/G6PC3/GLA/PGM1/GALE	1.79370216401713
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	10/1097	52/9376	1.64364350326064	LRPAP1/PLTP/VDAC1/VDAC2/ANGPTL4/NPC2/SCARB1/CIDEB/CYP27A1/LPL	1.69412690644854
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	15/1097	87/9376	1.47361141671644	BAX/MAP2K2/JUN/RPS6KB2/BAD/CYCS/GADD45A/RALB/HRAS/PMAIP1/BAK1/TGFB2/RAC3/BBC3/BCL2L11	1.61546412640857
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	22/1097	138/9376	1.36255664328273	RPS6/MAP2K2/PRKAR2B/RPS6KB2/BAD/EIF4EBP1/HRAS/SORBS1/G6PC3/SOCS2/EIF4E2/PRKCZ/PPP1R3B/PRKAR1B/SOCS1/CALM1/PPP1R3F/SOCS3/SHC3/PPP1R3D/PYGM/PPP1R3E	1.56180368157578
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	37/1097	253/9376	1.24994865623457	RPS27A/BAX/ACTN1/JUN/RPS6KB2/NFKBIB/CYCS/ARPC5/ARPC5L/PLCG2/VDAC1/SHARPIN/TLN1/ACTR3B/UBE2V2/ARPC1B/MYL12A/PYCARD/PPID/MAPK12/UBA52/MAP1LC3B/UBC/UBE2V1/CBX3/ARPC3/CGAS/UBE2D4/U2AF1/MYL5/SEPTIN6/ARPC2/PLCB2/SQSTM1/TRAF2/C3/PRKCQ	1.46704096176995
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	14/1097	82/9376	1.45923471996798	CES1/GSTM3/GSTM5/GSTP1/NME1/GUSB/NME4/HPRT1/NME6/IMPDH1/GSTO1/GSTM1/GSTM4/GSTM2	1.52033858546626
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	6/1097	28/9376	1.83148847506186	HSD17B12/ACAA2/TECR/ECHS1/PPT1/ACOT2	1.6038949076587
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	6/1097	28/9376	1.83148847506186	ATP6V0D1/ATP6V0C/ATP6V1F/ATP6V1E2/ATP6V1B2/ATP6V1G2	1.6038949076587
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	34/1097	233/9376	1.24719386856859	CSRP1/TPM1/LMOD1/FHL3/TPM4/FHL2/FHL1/PDLIM4/SSPN/VIM/TLN1/ITGA6/SGCE/PDLIM2/TPM2/SYNPO2/FMNL2/ENO1/PDLIM7/ZYX/CAPZB/PDLIM1/MYL5/MYL3/DTNA/SDC4/BGN/THBS1/DES/MYH11/COL4A4/SPTBN2/COL24A1/NID2	1.39082121167709
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	4/1097	16/9376	2.13673655423883	GLA/A4GALT/B3GALNT1/ST8SIA1	1.65646362534666
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	36/1097	250/9376	1.23076025524157	PSD/RAB11B/ARPC5/ARPC5L/HSPA8/SNF8/WASHC3/VPS25/HRAS/ACTR3B/SH3GLB2/ARPC1B/MVB12A/CLTA/GRK6/ARF5/ARPC3/SMAP2/CAPZB/PRKCZ/CAV2/SNX3/AP2S1/AP2M1/GRK5/VPS28/SPART/ARF4/DNM3/ARRB2/ARPC2/PARD6B/PIP5KL1/EHD3/AGAP9/PLD1	1.34614174859822
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	12/1097	70/9376	1.46519078004949	EPHX1/GSTM3/CYP1B1/GSTM5/GSTP1/CBR1/GSTK1/HSD11B1L/GSTO1/GSTM1/GSTM4/GSTM2	1.42199675438638
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	13/1097	78/9376	1.42449103615922	C1D/HSPD1/BTG1/EXOSC5/BTG2/EXOSC2/LSM4/MPHOSPH6/ENO1/LSM3/EXOSC8/EXOSC4/NUDT16	1.37031706109577
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	8/1097	43/9376	1.59012952873588	ACADVL/ACAA2/ECI2/ECHS1/ACADS/ADH1C/ALDH1B1/CYP2U1	1.41179276471957
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	13/1097	79/9376	1.40645950405594	EPHX1/GSTM3/CYP1B1/GSTM5/GSTP1/CBR1/GSTK1/ADH1C/HSD11B1L/GSTO1/GSTM1/GSTM4/GSTM2	1.32056390881133
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	13/1097	79/9376	1.40645950405594	VAMP2/ATP6V0D1/ATP6V0C/ATP6V1F/CLTA/AP2S1/AP2M1/ATP6V1E2/ATP6V1B2/DNM3/ATP6V1G2/RAB3A/SLC1A1	1.32056390881133
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	4/1097	17/9376	2.01104616869537	CYP39A1/SLC27A5/ACOX2/CYP27A1	1.51873057256477
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	4/1097	17/9376	2.01104616869537	CA4/CA13/CA8/CA1	1.51873057256477
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	32/1097	224/9376	1.2209923167079	BAX/MAP2K2/SLC25A6/JUN/ANAPC13/FDPS/CD4/SLC25A5/LTBR/VDAC1/TLN1/HRAS/RAN/VDAC2/CDK4/ETS2/ATF4/CREB3/ANAPC11/TGFB2/CDKN2A/RANBP1/CHEK2/RELB/NFKB2/ANAPC2/CDK2/SLC25A4/CDKN2B/PTTG1/HLA-DQB1/ADCY2	1.21854953659699
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	7/1097	37/9376	1.61698982482939	BAX/MAP2K2/GADD45A/HRAS/BAK1/TPR/NTRK1	1.36876435497359
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	8/1097	44/9376	1.55399022126461	DAD1/B4GALT2/KRTCAP2/ALG3/ALG12/ALG14/DDOST/B4GALNT3	1.34072924529371
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	35/1097	248/9376	1.20622224836063	GAPDH/HSP90AB1/BAX/RPS3/MAP2K2/JUN/CYCS/ARPC5/ARPC5L/DYNLRB1/STX10/HRAS/ACTR3B/GSDMD/ARPC1B/MYL12A/PYCARD/MAPK12/RRAS/BAK1/TUBA1B/TUBA1A/DYNLT3/ARPC3/TUBB2A/TXN/IRAK1/BRK1/ANXA2/MYL5/ARPC2/RHOJ/TRAF2/RILP/ARHGEF26	1.19804616388145
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	13/1097	80/9376	1.38887876025524	RPS6/BAX/MAP2K2/RPS6KB2/BAD/PLCG2/EIF4EBP1/GAS6/HRAS/EIF4E2/SHC3/NRG2/BCL2L11	1.27148479251939
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	10/1097	59/9376	1.44863495202633	NME1/DCTPP1/ASMTL/NME4/DTYMK/HDDC2/NT5C/NME6/DHODH/NT5M	1.25829095315201
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	6/1097	31/9376	1.65424765489458	GET3/SEC11C/OXA1L/UBL4A/SRPRB/SGTA	1.32810795914782
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	7/1097	38/9376	1.57443746101809	BST1/NMRK1/QPRT/NT5C/SIRT2/NT5M/NAMPT	1.29153930715098
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	20/1097	134/9376	1.27566361447095	MAP2K2/ACTA2/RAMP1/PPP1R14A/MYL6B/KCNMB1/GUCY1A1/MYLK/PLA2G4C/RAMP2/CALM1/PLCB2/EDN3/MYL6/GUCY1B1/MYH11/ADM/ADRA1D/PRKCQ/ADCY2	1.1699003585
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	23/1097	157/9376	1.25210040121002	MAP2K2/SLC25A6/GADD45A/SLC25A5/EIF4EBP1/VDAC1/HRAS/VDAC2/CDK4/PPID/MAPK12/RRAS/TGFB2/CDKN2A/MRAS/HUS1/CHEK2/CALM1/CDK2/SQSTM1/SLC25A4/CDK1/CDKN2B	1.15952860316676
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	4/1097	18/9376	1.89932138154563	ACSF3/MCAT/OXSM/HSD17B8	1.39014359094227
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	21/1097	142/9376	1.26398500391593	HSP90AB1/GSTM3/GSTM5/JUN/GSTP1/CYBA/BMP4/SUMO3/MAPK12/GSTO1/TXN/PRKCZ/GSTM1/CAV2/RAC3/GSTM4/CALM1/SDC4/SQSTM1/MAP3K5/GSTM2	1.15379460670844
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	3/1097	12/9376	2.13673655423883	VKORC1/COQ4/COQ7	1.43423315265419
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	23/1097	158/9376	1.24417571512641	RPS6/WNT2/MAP2K2/RPS6KB2/EIF4EBP1/HRAS/ATP6V1F/LAMTOR4/TBC1D7/MLST8/LPIN3/LAMTOR2/WNT5A/EIF4E2/SLC3A2/LRP5/ATP6V1E2/NPRL2/ATP6V1B2/ATP6V1G2/WNT2B/FZD10/DEPTOR	1.12671135354868
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	7/1097	39/9376	1.53406726970993	GCSH/MTHFS/BHMT2/MTHFD1L/BHMT/AMT/CHDH	1.21653497104885
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	15/1097	98/9376	1.30820605361561	RPS6KB2/ARPC5/ARPC5L/PLCG2/ACTR3B/ARPC1B/CFL1/ARPC3/PLA2G4C/MARCKSL1/GSN/ARPC2/PLPP2/SPHK1/PLD1	1.1164185117843
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	13/1097	83/9376	1.33867832313758	PRDX5/PMVK/GSTK1/ECH1/ECI2/SOD1/PEX10/PEX16/MLYCD/PEX11A/MPV17L2/MPV17L/ACOX2	1.12810231157811
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	13/1097	83/9376	1.33867832313758	GSDME/NFKBIB/POLR2F/POLR2E/GSDMD/POLR3K/PYCARD/DNASE2/POLR3GL/POLR3D/CGAS/POLR2L/POLR3B	1.12810231157811
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	4/1097	19/9376	1.79935709830639	GCSH/PDHA1/PDHB/AMT	1.26954860406491
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	5/1097	26/9376	1.64364350326064	TCN2/SLC19A1/SCARB1/SLC46A1/AMN	1.19626189503584
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	12/1097	77/9376	1.33199161822681	BAX/RPS6KB2/BAD/GADD45A/RALB/CDK4/RALBP1/BAK1/TGFB2/CDKN2A/RAC3/PLD1	1.06476647517982
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	24/1097	170/9376	1.20662770121722	RAB13/ACTN1/JUN/ARPC5/ARPC5L/MYL6B/ACTR3B/ARPC1B/CDK4/MYL12A/TUBA1B/TUBA1A/ARPC3/AMOTL2/PRKCZ/AMOT/CLDN10/ARPC2/JAM2/MYL6/MAP3K5/MYH11/EPB41L4B/PARD6B	0.989640659880436
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	10/1097	63/9376	1.35665812967545	BAX/WNT2/GADD45A/BMP4/BAK1/WNT5A/GLI1/KIF7/WNT2B/FZD10	1.03389780125042
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	7/1097	41/9376	1.45923471996798	MAP2K2/RASSF1/DAPK3/HRAS/CDK4/CDKN2A/THBS1	1.07267829475924
Genetic Information Processing	Transcription	hsa03040	Spliceosome	33/1097	243/9376	1.16069639983344	HNRNPA1/SNRPD1/PHF5A/PUF60/DDX46/SF3A2/EIF4A3/PQBP1/THOC3/PRPF38B/SNRNP40/SNW1/HSPA8/CDC5L/DHX16/BUD31/SNRPD3/PPIL1/SNRPB/LSM4/TXNL4A/NCBP2/LSM3/SRSF9/SRSF3/SYF2/THOC5/CWC15/GPKOW/U2AF1/XAB2/SNU13/HNRNPA1L2	0.923852345635544
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	18/1097	125/9376	1.23076025524157	BAX/MAP2K2/ASAH1/CTSD/DEGS1/HRAS/MAPK12/ORMDL2/BID/PRKCZ/RAC3/SMPD2/PLCB2/PPP2R5B/TRAF2/MAP3K5/SPHK1/PLD1	0.945413255898956
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	6/1097	35/9376	1.46519078004949	TPI1/SORD/PMM1/ALDOA/TKFC/KHK	1.00361800818341
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	5/1097	28/9376	1.52624039588488	B4GALT2/ST3GAL4/A4GALT/B3GALNT1/ST8SIA1	1.01508838243521
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	4/1097	21/9376	1.62798975561054	PPCS/COASY/CSAD/ALDH1B1	1.04867356708183
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	8/1097	51/9376	1.34069744579691	ATP6V0D1/KDELR3/PLCG2/ATP6V0C/ATP6V1F/ATP6V1E2/ATP6V1B2/ATP6V1G2	0.888033922970021
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	3/1097	15/9376	1.70938924339107	ST6GALNAC4/ST8SIA1/ST3GAL5	1.00085028341413
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	11/1097	75/9376	1.25355211182012	GAPDH/TKT/TPI1/PYCR1/PGAM1/IDH3B/ALDOA/ENO1/IDH3G/ACY1/PHGDH	0.802477847169002
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	6/1097	37/9376	1.38599127842519	NANS/PGM2/GALK1/PMM1/PGM1/GALE	0.856304402402718
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	9/1097	60/9376	1.2820419325433	MAP2K2/BAD/PLCG2/HRAS/MAPK12/SH2D2A/PLA2G4C/RAC3/SPHK1	0.797764263326297
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	4/1097	23/9376	1.48642542903571	POLD2/RFC2/RFC3/RFC4	0.850167956723478
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	20/1097	148/9376	1.15499273202099	BAX/WNT2/MAP2K2/JUN/RPS6KB2/FGF10/GADD45A/HRAS/CDK4/FRAT2/BAK1/WNT5A/LRP5/FGFR1/NOTCH4/SHC3/NFKB2/WNT2B/NOTCH1/FZD10	0.691812506717238
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	6/1097	38/9376	1.34951782372979	GNPDA1/PGM2/GALK1/PMM1/PGM1/GALE	0.785840128004252
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	27/1097	205/9376	1.12569535540387	BAX/ACTN1/JUN/BAD/ATP6V0D1/SNW1/LTBR/MRPS18B/HRAS/CDK4/PMAIP1/BAK1/YWHAE/ATF4/CREB3/CDKN2A/RANBP1/YWHAB/GSN/HDAC11/HDAC10/NFKB2/CDK2/TRAF2/C3/CDK1/CDKN2B	0.662350433316574
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	7/1097	46/9376	1.30062225040625	GUSB/HMBS/HMOX2/BLVRB/HCCS/FTH1/ALAS1	0.743976514551454
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	5/1097	31/9376	1.37853971241215	ECHS1/CSAD/ACADS/ALDH1B1/MLYCD	0.768427064502219
NA	NA	hsa04981	Folate transport and metabolism	5/1097	31/9376	1.37853971241215	MTHFS/BHMT2/BHMT/SLC19A1/SLC46A1	0.768427064502219
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	8/1097	54/9376	1.26621425436375	ERCC1/CENPX/ERCC4/CENPS/PALB2/FAAP100/FAAP24/EME2	0.71412403011779
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	4/1097	24/9376	1.42449103615922	B4GALT7/B3GALT6/B3GAT3/HS3ST3B1	0.757917450138471
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	26/1097	200/9376	1.11110300820419	GAPDH/BAX/RPS3/JUN/NFKBIB/NCL/CYCS/ARPC5/ARPC5L/ACTR3B/ARPC1B/PYCARD/MAPK12/BAK1/LPAR1/TUBA1B/TUBA1A/ARPC3/MYO1E/TUBB2A/IRAK1/BRK1/CLDN10/ARPC2/TRAF2/MYH11	0.578114848453853
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	9/1097	63/9376	1.2209923167079	GPX4/PTGES2/CBR1/PTGDS/PTGR1/PLA2G4C/CYP2U1/GGT5/PTGIS	0.640623194389132
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	10/1097	71/9376	1.20379524182469	JUN/ATP6V0D1/PLCG2/ATP6V0C/ATP6V1F/MAPK12/ATP6V1E2/ATP6V1B2/ATP6V1G2/JAM2	0.627429647515786
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	3/1097	17/9376	1.50828462652153	CDO1/CSAD/GGT5	0.763513502908592
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	7/1097	48/9376	1.24642965663932	ACAA2/HSD17B10/ECHS1/ACADS/MCEE/ALDH1B1/ACSF3	0.623044881610234
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	22/1097	169/9376	1.11262021759182	RPS27A/MAP2K2/RPS6KB2/BAD/IGBP1/DAPK3/CTSD/HRAS/NRBF2/ATG101/MLST8/UBA52/WDR45/RRAS/MAP1LC3B/UBC/GORASP1/GABARAPL2/MRAS/SQSTM1/DEPTOR/PRKCQ	0.537775055200714
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	14/1097	104/9376	1.15055045228245	PEMT/CHKB/ADPRM/AGPAT2/GDPD5/LPIN3/PTDSS2/PLPP4/PLA2G4C/DGKA/PNPLA6/GPAT2/PLPP2/PLD1	0.561968578491149
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	5/1097	33/9376	1.29499185105384	PDHA1/IDH3B/PDHB/IDH3G/ACY1	0.617908010303193
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	12/1097	89/9376	1.15239724273555	MAP2K2/HRAS/GUCY1A1/LPAR1/TUBA1B/TUBA1A/TUBB2A/PLCB2/GUCY1B1/CDK1/ADCY2/ADRB1	0.525816730944701
Human Diseases	Cancer: specific types	hsa05218	Melanoma	10/1097	73/9376	1.17081455026785	BAX/MAP2K2/FGF10/BAD/GADD45A/HRAS/CDK4/BAK1/CDKN2A/FGFR1	0.53330393988501
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	10/1097	73/9376	1.17081455026785	BAX/MAP2K2/BAD/GADD45A/RASSF1/PLCG2/HRAS/CDK4/BAK1/CDKN2A	0.53330393988501
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	27/1097	212/9376	1.08852616914054	MAP2K2/NGFR/VEGFB/FGF10/RALB/TLN1/HRAS/MAPK12/RRAS/LPAR1/KITLG/PRKCZ/MRAS/RAC3/P2RY1/CALM1/FGFR1/ANGPT1/RAP1B/RGS14/PLCB2/RASGRP2/THBS1/GNAO1/PARD6B/ADCY2/NGF	0.474566493636265
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	3/1097	18/9376	1.42449103615922	CD320/ZNF143/TCN2	0.656165310242039
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	9/1097	66/9376	1.16549266594845	CYP1B1/HSD17B12/HSD11B2/SRD5A3/HSD17B1/HSD11B1L/CYP11A1/DHRS11/HSD17B8	0.491106735062462
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	5/1097	34/9376	1.25690385543461	DBP/NR1D1/PER3/NPAS2/BHLHE41	0.5462483770328
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	7/1097	50/9376	1.19657247037375	SRM/PYCR1/SAT2/GAMT/SMS/ALDH1B1/P4HA3	0.507294323717718
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	15/1097	115/9376	1.11481907177678	NACA/PTH1R/WNK2/PDE4D/ATF4/CREB3/LRP5/FGFR1/JUND/BGLAP/ARRB2/PLCB2/RUNX2/ADCY2/PLD1	0.450955845035053
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	13/1097	99/9376	1.12232627091333	BAX/MAP2K2/JUN/RPS6KB2/BAD/HRAS/CDK4/MAPK12/CDKN2A/NOTCH4/SHC3/NOTCH1/ADCY2	0.445382928221408
NA	NA	hsa04517	IgSF CAM signaling	37/1097	299/9376	1.05764886296772	MAP2K2/ACTN1/PPFIA2/ARPC5/ARPC5L/PLCG2/MYL6B/SORBS1/ACTR3B/EPB41L3/ARPC1B/MYL12A/MAPK12/TUBA1B/MYLK/TUBA1A/NRP2/ICAM3/CNTN1/ARPC3/TUBB2A/NCAM2/PVR/FGFR1/PPFIA3/DOK1/ARPC2/ICAM2/RAP1B/JAM2/UNC5B/MYL6/MYH11/PARD6B/SPTBN2/PRKCQ/PLXNA2	0.368769660158545
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	14/1097	108/9376	1.10793747256828	EIF4A3/THOC3/PHAX/SNUPN/PNN/RAN/SUMO3/NCBP2/TPR/RAE1/NUP42/THOC5/SAP18/NUP210L	0.410668243264429
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	21/1097	166/9376	1.08124018407266	MAP2K2/SLC25A6/ADRA2C/BAD/SLC25A5/VDAC1/VDAC2/KCNMB1/GUCY1A1/ATF4/CREB3/MYLK/CALM1/PLCB2/MEF2B/GUCY1B1/SLC25A4/ATP2A1/ADRA1D/ADCY2/ADRB1	0.384410408517863
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	3/1097	19/9376	1.34951782372979	GUSB/IDUA/GALNS	0.55510843170355
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	20/1097	158/9376	1.08189192619688	ANAPC13/GADD45A/MAD2L2/CDC25B/CDK4/YWHAE/FBXO5/ANAPC11/TGFB2/CDKN2A/YWHAB/CHEK2/MAD2L1BP/ANAPC2/CDK2/PPP2R5B/CDK1/CDKN1C/CDKN2B/PTTG1	0.377877722042199
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	15/1097	117/9376	1.09576233550709	SMARCB1/MORF4L2/SMARCD3/POLE3/INO80E/RUVBL1/ZNHIT1/TFPT/INO80B/CDK2AP2/MRGBP/YEATS4/INO80C/MTA2/DPF1	0.37940725297778
Human Diseases	Cancer: specific types	hsa05214	Glioma	10/1097	76/9376	1.12459818644149	BAX/MAP2K2/GADD45A/PLCG2/HRAS/CDK4/BAK1/CDKN2A/CALM1/SHC3	0.396987702351658
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	13/1097	101/9376	1.10010198832098	WNT2/MAP2K2/HRAS/CREB3/WNT5A/KITLG/POMC/CALM1/PLCB2/WNT2B/FZD10/GNAO1/ADCY2	0.368168342546245
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	13/1097	101/9376	1.10010198832098	BAX/JUN/VEGFB/PLCG2/PIM1/HRAS/CDK4/F3/MAPK12/TGFB2/PRKCZ/PLCB2/COL4A4	0.368168342546245
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	7/1097	52/9376	1.15055045228245	CYP1B1/HSD17B1/ACOT2/PLA2G4C/CYP11A1/SCARB1/ADCY2	0.396262171058395
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	10/1097	77/9376	1.109993015189	BAX/MAP2K2/BAD/GADD45A/HRAS/CDK4/BAK1/TGFB2/CDKN2A/SHC3	0.352770578072807
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	5/1097	36/9376	1.18707586346602	AKR1A1/GUSB/SORD/DCXR/CRYL1	0.409350741477449
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	4/1097	28/9376	1.2209923167079	MOCS2/CBR1/TH/SPR	0.426281857211717
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/1097	12/9376	1.42449103615922	NGFR/NCAM2	0.535585061282518
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	7/1097	53/9376	1.12884195318278	PTH1R/CLTA/AP2S1/AP2M1/DNM3/PLCB2/KLK1	0.34238710766731
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	12/1097	95/9376	1.07961425898383	JUN/ATP6V0D1/ATP6V0C/CTSK/ATP6V1F/TGFB2/CXCL12/ANGPT1/ATP6V1E2/ATP6V1B2/ATP6V1G2/HLA-DQB1	0.283893392242457
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	9/1097	70/9376	1.09889308503711	MAP2K2/JUN/BAD/EGLN3/HRAS/TGFB2/ELOB/ELOC/RAP1B	0.302296717787643
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	19/1097	155/9376	1.04769018143323	WNT2/MAP2K2/AIP/CDK4/ORAI1/ATF4/CREB3/WNT5A/POMC/CYP11A1/CDKN2A/RAP1B/SCARB1/PLCB2/CDK2/WNT2B/FZD10/CDKN2B/ADCY2	0.217924382186148
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	3/1097	21/9376	1.2209923167079	B4GALT7/B3GALT6/B3GAT3	0.369032773208929
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	9/1097	71/9376	1.08341571764223	MAP2K2/HRAS/MAPK12/SOCS2/TH/SOCS1/SOCS3/SHC3/PRL	0.256814113268447
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	9/1097	71/9376	1.08341571764223	MAP2K2/LDHA/LDHB/PGAM1/PDHA1/HRAS/PDHB/FGFR1/NTRK1	0.256814113268447
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	16/1097	130/9376	1.05193184208681	MAP2K2/JUN/VEGFB/ACTA2/HRAS/MAPK12/ATF4/CREB3/PRKCZ/GNG4/SHC3/ARRB2/PLCB2/GNAO1/COL4A4/ADCY2	0.217034347552306
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	13/1097	105/9376	1.05819334114685	TPM1/TPM4/SSPN/ITGA6/SGCE/TPM2/TGFB2/MYL3/DTNA/DES/ATP2A1/ADCY2/ADRB1	0.218275334500857
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	17/1097	140/9376	1.03784346920172	RPS6/MAP2K2/ACTA2/RPS6KB2/TFAM/HRAS/RRAS/MAP1LC3B/MYLK/GNG4/MRAS/CALM1/MYL3/PLCB2/MEF2B/SPHK1/ADCY2	0.164215069625043
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	18/1097	149/9376	1.03251699265232	MAP2K2/PLCG2/RALB/HRAS/AGPAT2/RRAS/LPAR1/PLA2G4C/KITLG/MRAS/DNM3/DGKA/SHC3/PLCB2/PLPP2/SPHK1/ADCY2/PLD1	0.14563751415049
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	7/1097	56/9376	1.06836827711942	EEF1G/CYCS/HSPD1/HSPA8/PYCARD/NFKB2/C3	0.186784443936992
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	9/1097	73/9376	1.05373309524107	GSTM3/GSTM5/GSTP1/GSTK1/ADH1C/GSTO1/GSTM1/GSTM4/GSTM2	0.167761302238848
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	9/1097	73/9376	1.05373309524107	PPIA/PSIP1/SMARCB1/CD4/FEZ1/SUPT4H1/RAN/NELFE/PIN1	0.167761302238848
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	22/1097	184/9376	1.02191748246205	BOC/EFNB2/PLCG2/HRAS/MYL12A/CFL1/RRAS/WNT5A/RHOD/PRKCZ/RAC3/EPHB4/CDK5/SEMA3A/CXCL12/MYL5/RGS3/SEMA3F/UNC5B/RND1/PARD6B/PLXNA2	0.109293562435471
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	8/1097	65/9376	1.05193184208681	ORAI1/ATF4/CREB3/POMC/CYP11A1/SCARB1/PLCB2/ADCY2	0.152929846818648
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	4/1097	31/9376	1.10283176992972	TKT/PGM2/ALDOA/PGM1	0.208746169856619
Organismal Systems	Immune system	hsa04611	Platelet activation	15/1097	126/9376	1.01749359725659	PLCG2/TLN1/MYL12A/MAPK12/GUCY1A1/ORAI1/MYLK/PLA2G4C/PRKCZ/P2RY1/RAP1B/PLCB2/RASGRP2/GUCY1B1/ADCY2	0.0719603953534891
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3/1097	23/9376	1.11481907177678	CA4/MDH1/SLC25A10	0.200679261030548
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	13/1097	109/9376	1.0193605579855	RPS6KB2/NR1H2/G6PC3/CREB3/PRKCZ/PPP1R3B/SLC27A5/SOCS3/PPP1R3D/PYGM/PPP1R3E/TRIB3/PRKCQ	0.0740050826501393
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	28/1097	238/9376	1.00552308434769	MAP2K2/NGFR/VEGFB/FGF10/IGF2/BAD/RASSF1/PLCG2/RALB/HRAS/ETS2/RRAS/RALBP1/PLA2G4C/KITLG/GNG4/MRAS/RAC3/CALM1/FGFR1/ANGPT1/NTRK1/SHC3/RAP1B/RIN1/RASGRP2/NGF/PLD1	0.0314155442629
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	6/1097	49/9376	1.04656484289249	JUN/ATF4/CREB3/TH/CDK5/DLG4	0.118955685584088
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	4/1097	32/9376	1.06836827711942	IGBP1/ATG101/MLST8/GABARAPL2	0.141014321070529
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	11/1097	93/9376	1.01092912243558	BAX/CYCS/GADD45A/LAMC3/ITGA6/CDK4/BAK1/CDK2/TRAF2/COL4A4/CDKN2B	0.0385551681012122
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	25/1097	214/9376	0.998475025345249	BAX/MAP2K2/JUN/RPS6KB2/AP1S1/BAD/CYCS/CD4/PLCG2/TAPBPL/HRAS/CFL1/MAPK12/BAK1/BID/CGAS/GNG4/ELOB/IRAK1/RAC3/ELOC/CALM1/TRAF2/CDK1/GNAO1	-0.00821437224084673
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	2/1097	15/9376	1.13959282892738	ACP1/AK1	0.196946209286581
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	4/1097	33/9376	1.03599348084307	VAMP2/VTI1B/USE1/VAMP5	0.0753941508966252
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	20/1097	173/9376	0.988086267856108	BAX/MAP2K2/SLC25A6/NFKBIB/RAB11B/CYCS/FDPS/SLC25A5/PABPN1/VDAC1/CDK4/PYCARD/BAK1/RAE1/BID/SOCS3/DNAJB1/BCL2L2-PABPN1/SLC25A4/HLA-DQB1	-0.0575713194398635
Organismal Systems	Nervous system	hsa04730	Long-term depression	7/1097	60/9376	0.997143725311456	MAP2K2/HRAS/GUCY1A1/PLA2G4C/PLCB2/GUCY1B1/GNAO1	-0.00807906062838528
Organismal Systems	Endocrine system	hsa04924	Renin secretion	8/1097	69/9376	0.990950286023807	GUCY1A1/ORAI1/CALM1/PLCB2/EDN3/GUCY1B1/PTGER2/ADRB1	-0.0274634158032592
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	16/1097	139/9376	0.983821147275434	HSP90AB1/MAP2K2/JUN/HSPA8/FKBP4/KRT10/CTSD/HRAS/ATF4/CREB3/POMC/CALM1/SHC3/PLCB2/GNAO1/ADCY2	-0.069950312764682
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	9/1097	78/9376	0.986186101956385	JUN/C2/PYCARD/CFL1/MAPK12/IRAK1/IRF8/CALM1/C3	-0.0445932153024394
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	9/1097	78/9376	0.986186101956385	JUN/NFKBIB/CYBA/MAPK12/TGFB2/IRAK1/MARCKSL1/C3/HLA-DQB1	-0.0445932153024394
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	10/1097	88/9376	0.971243888290379	CFI/C2/CD59/CLU/F3/F2RL2/C6/C3/CFD/F8	-0.098653024746575
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	12/1097	106/9376	0.967578817013811	HSP90AB1/MAP2K2/GSTP1/BAD/HRAS/ATF4/CREB3/INSRR/SLC19A1/FGFR1/CDK2/SLC46A1	-0.122191763760871
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	17/1097	150/9376	0.968653904588271	BAX/WNT2/MAP2K2/RPS6KB2/FGF10/GADD45A/HRAS/FRAT2/BAK1/WNT5A/TGFB2/LRP5/SHC3/CDK2/WNT2B/FZD10/CDKN2B	-0.140871249347267
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	19/1097	168/9376	0.966618917393758	HSP90AB1/BAX/PPIA/SLC25A6/PARP1/SLC25A5/VDAC1/SHARPIN/VDAC2/PYCARD/PPID/PLA2G4C/BID/FTH1/PYGM/SQSTM1/SPATA2L/TRAF2/SLC25A4	-0.158917752256345
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	16/1097	142/9376	0.963036193459756	RPS27A/ANAPC13/UBE2M/STUB1/UBE2Q1/UBE2S/UBA52/UBC/ANAPC11/ELOB/ELOC/UBE2D4/SOCS1/SOCS3/ANAPC2/NHLRC1	-0.161557058154448
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	16/1097	142/9376	0.963036193459756	JUN/FHL2/PLCG2/CYBA/CTSK/MAPK12/TGFB2/SOCS1/RELB/JUND/SOCS3/NFKB2/TMEM64/SQSTM1/TRAF2/ATP2A1	-0.161557058154448
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	12/1097	107/9376	0.958536024331439	LDHA/LDHB/PGAM1/PDHA1/PDHB/G6PC3/ATF4/CREB3/CALM1/PLCB2/PYGM/ADCY2	-0.157016900234226
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/1097	17/9376	1.00552308434769	SEPHS2/TXNRD3	0.00829643325240904
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/1097	17/9376	1.00552308434769	NRP2/MYH11	0.00829643325240904
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	23/1097	204/9376	0.963626289166532	RPS6/WNT2/MAP2K2/RPS6KB2/IGF2/PLCG2/CD63/TFAP4/TWIST1/HRAS/MAPK12/RRAS/NUDT16L1/WNT5A/TGFB2/CAV2/MRAS/PDCD4/FGFR1/SDC4/THBS1/WNT2B/FZD10	-0.191192424837173
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	21/1097	187/9376	0.95981748960461	HSP90AB1/JUN/NFKBIB/CYBA/VDAC1/SHARPIN/VDAC2/GSDMD/PYCARD/MAPK12/YWHAE/MAP1LC3B/TXN/CARD9/GABARAPL2/CARD16/TXNIP/CARD6/PLCB2/NAMPT/TRAF2	-0.202033670434472
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	11/1097	99/9376	0.949660690772815	MAP2K2/JUN/RPS6KB2/CHKB/EIF4EBP1/HRAS/PLA2G4C/RAC3/DGKA/PLPP2/PLD1	-0.183282534330932
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	11/1097	99/9376	0.949660690772815	TPM1/TPM4/SSPN/ITGA6/SGCE/TPM2/TGFB2/MYL3/DTNA/DES/ATP2A1	-0.183282534330932
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	4/1097	36/9376	0.949660690772815	PGM2/G6PC3/PGM1/PYGM	-0.11015014537861
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	4/1097	36/9376	0.949660690772815	ST6GALNAC4/C1GALT1C1L/GALNT8/ST6GALNAC2	-0.11015014537861
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	26/1097	232/9376	0.957847420865684	MAP2K2/ACTN1/FGF10/ARPC5/ARPC5L/ITGA6/HRAS/ACTR3B/ARPC1B/MYL12A/CFL1/RRAS/LPAR1/MYLK/ARPC3/INSRR/MRAS/RAC3/CXCL12/BRK1/GSN/FGFR1/MYL5/ARPC2/MYH11/C6	-0.236646478847709
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	3/1097	27/9376	0.949660690772815	ECHS1/ACADS/ACSM3	-0.0953468971769757
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/1097	27/9376	0.949660690772815	HSD17B12/TECR/ACOT2	-0.0953468971769757
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	6/1097	55/9376	0.932394132758763	ASAH1/DEGS1/GLA/SMPD2/PLPP2/SPHK1	-0.183035145875366
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	2/1097	18/9376	0.949660690772815	AGA/FUCA1	-0.0778129704581945
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	4/1097	37/9376	0.923994185616793	FAH/FAHD1/ADH1C/TH	-0.16861550273903
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	15/1097	138/9376	0.929015893147319	ANAPC13/MAD2L2/MAPK12/YWHAE/FBXO5/ANAPC11/YWHAB/CALM1/ANAPC2/CDK2/PPP2R5B/CDK1/PTTG1/STAG3/ADCY2	-0.305781845319632
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	15/1097	138/9376	0.929015893147319	MAP2K2/JUN/ARPC5/CD4/ARPC5L/ACTR3B/ARPC1B/PYCARD/MAPK12/ARPC3/IRAK1/RAC3/ARHGEF28/ARPC2/TRAF2	-0.305781845319632
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	10/1097	93/9376	0.919026474941434	ACTN1/ACP1/SORBS1/MYL12A/RAC3/SNAI1/FGFR1/MYL5/RAP1B/RASIP1	-0.285654030209969
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	10/1097	93/9376	0.919026474941434	MAP2K2/JUN/HRAS/MAPK12/ATF4/PLA2G4C/CALM1/PLCB2/ADCY2/PLD1	-0.285654030209969
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	17/1097	156/9376	0.93139798518103	BAX/MAP2K2/BAD/CYCS/CD81/HRAS/CDK4/EIF3E/BAK1/YWHAE/BID/YWHAB/CLDN10/SOCS3/SCARB1/CDK2/TRAF2	-0.314509465345734
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	12/1097	112/9376	0.915744237530928	NFKBIB/BAD/CYCS/LAMC3/HSPA8/ITGA6/MAPK12/TGFB2/IRAK1/SOCS1/GNAO1/HLA-DQB1	-0.326519679781345
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	11/1097	103/9376	0.912780663946686	EIF4A3/PABPN1/SSU72/PNN/PELO/NCBP2/GSPT1/GSPT2/SAP18/BCL2L2-PABPN1/PPP2R5B	-0.323982289015661
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	11/1097	103/9376	0.912780663946686	COL16A1/COL23A1/SLC3A2/COL21A1/COL8A1/SLC1A1/COL4A4/COL24A1/KCNE3/SLC15A1/COL19A1	-0.323982289015661
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	3/1097	29/9376	0.884166850029862	RASSF1/RASSF4/TEAD4	-0.227402772345102
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	33/1097	300/9376	0.940164083865087	MAP2K2/NGFR/JUN/VEGFB/FGF10/IGF2/GADD45A/HSPA8/HRAS/CDC25B/ECSIT/MAPK12/RRAS/ATF4/PLA2G4C/TGFB2/KITLG/RPS6KA4/MRAS/IRAK1/RAC3/FGFR1/RELB/ANGPT1/JUND/NTRK1/ARRB2/NFKB2/RAP1B/RASGRP2/TRAF2/MAP3K5/NGF	-0.383420508876376
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	8/1097	76/9376	0.899678549153193	PLTP/SORBS1/UBC/ANGPTL4/SLC27A5/ACOX2/CYP27A1/LPL	-0.319638538936202
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	9/1097	86/9376	0.89444785991393	MAP2K2/JUN/RPS6KB2/BAD/PLCG2/EIF4EBP1/HRAS/SHC3/NRG2	-0.357938507134377
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/1097	20/9376	0.854694621695533	CYP51A1/DHCR7	-0.236783584874445
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/1097	20/9376	0.854694621695533	NANS/CYB5R1	-0.236783584874445
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	11/1097	105/9376	0.895394365585797	JUN/PLCG2/HRAS/PYCARD/MAPK12/RRAS/CARD9/MRAS/CALM1/RELB/NFKB2	-0.392361555333556
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	21/1097	196/9376	0.915744237530928	RPS27A/BAX/MAP2K2/JUN/CYCS/PLCG2/HRAS/CLEC2B/CDK4/MAPK12/UBA52/BAK1/MAP1LC3B/UBC/BID/GNG4/RCAN1/CALM1/MICA/TRAF2/C3	-0.433916653897846
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	6/1097	59/9376	0.869180971215797	BAX/MAP2K2/BAD/GADD45A/HRAS/BAK1	-0.366909443135933
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	8/1097	78/9376	0.876609868405675	TPI1/PLCG2/IMPA2/ITPKA/INPP1/PLCB2/SYNJ2/PIP5KL1	-0.398320784401991
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/1097	10/9376	0.854694621695533	TST	-0.167341872178325
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	3/1097	31/9376	0.82712382744729	AKR1A1/GUSB/ALDH1B1	-0.350934724788981
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	23/1097	217/9376	0.905897525299413	HSP90AB1/EPHX1/GSTM3/CYP1B1/GSTM5/MAP2K2/JUN/RPS6KB2/FGF10/BAD/EIF4EBP1/AIP/HRAS/ATF4/CREB3/GSTO1/GSTM1/GSTM4/ARRB2/CHRNA3/GSTM2/ADCY2/ADRB1	-0.510513102314912
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	7/1097	70/9376	0.854694621695533	NFKBIB/G6PC3/POMC/SOCS3/TRAF2/NFKBIE/PRKCQ	-0.444169973278183
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	7/1097	70/9376	0.854694621695533	CYCS/SSPN/SGCE/BID/RAC3/DTNA/HLA-DQB1	-0.444169973278183
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	5/1097	51/9376	0.837935903623072	PLA2G7/PLA2G4C/PAFAH1B3/PLPP2/PLD1	-0.422422935814972
Organismal Systems	Digestive system	hsa04978	Mineral absorption	6/1097	61/9376	0.840683234454623	SLC39A4/HMOX2/FTH1/STEAP2/SLC46A1/STEAP1	-0.454396501875708
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	24/1097	227/9376	0.903641890779418	BAX/MAP2K2/RPS6KB2/CYCS/EIF4EBP1/TAPBPL/HRAS/CDK4/MAPK12/BAK1/ATF4/CREB3/BID/CGAS/GNG4/CDKN2A/RAC3/CXCL12/CALM1/PLCB2/TRAF2/GNAO1/PTGER2/ADCY2	-0.534951481985639
Human Diseases	Infectious disease: viral	hsa05162	Measles	14/1097	136/9376	0.879832698804225	RACK1/BAX/JUN/NFKBIB/BAD/EIF3H/CYCS/HSPA8/CDK4/BAK1/BID/IRAK1/CDK2/BBC3	-0.513830390274611
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	10/1097	99/9376	0.863327900702559	PLCG2/MAPK12/PLA2G4C/CALM1/NTRK1/PLCB2/PTGER2/PRKCQ/ADCY2/NGF	-0.497615265607102
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	9/1097	90/9376	0.854694621695533	BAX/RPS6KB2/EIF4EBP1/HRAS/ATG101/ATF4/CREB3/EIF4E2/ADCY2	-0.504183484277784
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	9/1097	90/9376	0.854694621695533	MAP2K2/JUN/RPS6KB2/NFKBIB/CD4/HRAS/MAPK12/NFKBIE/PRKCQ	-0.504183484277784
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	16/1097	155/9376	0.882265415943776	ATP6V0D1/CYBA/ATP6V0C/ATP6V1F/TUBA1B/TUBA1A/TUBB2A/COLEC11/ATP6V1E2/ATP6V1B2/ATP6V1G2/SCARB1/THBS1/RILP/C3/HLA-DQB1	-0.537998299048527
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/1097	22/9376	0.776995110632303	HNMT/ALDH1B1	-0.381177320943993
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	6/1097	62/9376	0.82712382744729	SNW1/PSENEN/NOTCH4/TLE2/NOTCH1/PSEN2	-0.497121878977053
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	11/1097	110/9376	0.854694621695533	RPS6KB2/NBL1/BMP4/FST/TGFB2/EMP3/LRRC32/ID4/BAMBI/THBS1/CDKN2B	-0.557997039581897
Cellular Processes	Cell motility	hsa04814	Motor proteins	20/1097	194/9376	0.881128475974777	TPM1/ACTA2/TPM4/DYNLRB1/KIF9/MYL6B/TPM2/MYL12A/TUBA1B/TUBA1A/DYNLT3/MYO1E/TUBB2A/DNAL4/CAPZB/MYL5/MYL3/KIF7/MYL6/MYH11	-0.608989860999163
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/1097	23/9376	0.743212714517855	RXYLT1/B4GALT2	-0.448809434662382
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	2/1097	23/9376	0.743212714517855	FDPS/PMVK	-0.448809434662382
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	4/1097	44/9376	0.776995110632303	VAMP2/RAB11B/AQP3/CREB3	-0.539701181613367
Organismal Systems	Digestive system	hsa04970	Salivary secretion	9/1097	93/9376	0.82712382744729	VAMP2/BST1/GUCY1A1/CALM1/PLCB2/GUCY1B1/ADRA1D/ADCY2/ADRB1	-0.609863228521149
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	12/1097	122/9376	0.840683234454623	MAP2K2/DIO2/BAD/PLCG2/BMP4/HRAS/THRA/RCAN1/NOTCH4/PLCB2/NOTCH1/ATP2A1	-0.644728189342501
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	12/1097	122/9376	0.840683234454623	MAP2K2/PLCG2/HRAS/MAPK12/SOCS2/ATF4/CREB3/SOCS1/SOCS3/SHC3/PLCB2/ADCY2	-0.644728189342501
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	22/1097	216/9376	0.87052229987508	HSP90AB1/BAX/JUN/BAD/CYCS/HSPD1/CYBA/HSPA8/HSPA2/HRAS/PYCARD/MAPK12/ATF4/BID/IRAK1/MIB2/CALM1/XBP1/RAP1B/PLCB2/TRAF2/MAP3K5	-0.700767780673853
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	4/1097	45/9376	0.759728552618252	ABCA8/ABCB8/ABCA6/DEFB1	-0.588090735001861
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	23/1097	226/9376	0.869821960132622	GRIA4/MAP2K2/JUN/BAD/FXYD1/PDE4D/RRAS/ORAI1/CREB3/POMC/RAC3/GLI1/CALM1/VIPR2/RAP1B/EDN3/OXT/ATP2A1/PTGER2/ADCY2/TSHR/PLD1/ADRB1	-0.721076614747151
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	10/1097	105/9376	0.81399487780527	GADD45A/PARP1/LTBR/PLCG2/IRAK1/CXCL12/RELB/NFKB2/TRAF2/PRKCQ	-0.697680000250762
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	5/1097	56/9376	0.76312019794244	BOC/GAS1/GLI1/KIF7/ARRB2	-0.647163625755026
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/1097	13/9376	0.657457401304256	FEN1	-0.449861434031328
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	8/1097	86/9376	0.795064764367938	VAMP2/KCNMB1/ATF4/CREB3/TRPM4/PLCB2/RAB3A/ADCY2	-0.694957129638085
NA	NA	hsa04518	Integrin signaling	15/1097	154/9376	0.832494761391753	ACTN1/VEGFB/FLNB/PARVB/LAMC3/TLN1/ITGA6/ICAM3/LIMS1/RAC3/ICAM2/THBS1/C3/COL4A4/MADCAM1	-0.762915091657024
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	15/1097	154/9376	0.832494761391753	MAP2K2/JUN/MYL6B/HRAS/GUCY1A1/MYLK/PLA2G4C/RCAN1/CALM1/PLCB2/MYL6/GUCY1B1/OXT/GNAO1/ADCY2	-0.762915091657024
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	6/1097	67/9376	0.765398168682567	MAP2K2/HRAS/ATF4/CALM1/RAP1B/PLCB2	-0.701483232876052
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	11/1097	116/9376	0.81048627919404	ACTN1/THY1/PLCG2/CYBA/MYL12A/MAPK12/CXCL12/MYL5/CLDN10/RAP1B/JAM2	-0.747591182370927
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	11/1097	116/9376	0.81048627919404	GRIA4/PLA2G4C/GNG4/DLG4/SHANK2/PLCB2/SLC1A1/GNAO1/GRIK2/ADCY2/PLD1	-0.747591182370927
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	9/1097	97/9376	0.793015628377299	GRIA4/GUCY1A1/PER3/GNG4/CALM1/PLCB2/GUCY1B1/GNAO1/ADCY2	-0.745886669848871
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	4/1097	47/9376	0.727399678038752	SOCS2/PRKCZ/SOCS1/SOCS3	-0.6819582027667
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	18/1097	183/9376	0.840683234454623	EIF6/NHP2/NOP56/POP7/IMP3/UTP14A/RAN/AK6/RRP7A/RIOK2/RPP25L/NOB1/MPHOSPH10/GNL2/RIOK1/SNU13/TBL3/RPP25	-0.79224299209599
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	6/1097	68/9376	0.754142313260765	MAP2K2/RPS6KB2/BAD/EIF4EBP1/PIM1/HRAS	-0.740644958173881
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	9/1097	98/9376	0.784923632169367	PLCG2/PIP4P1/IMPA2/ITPKA/INPP1/CALM1/DGKA/PLCB2/SYNJ2	-0.779073725764366
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	9/1097	98/9376	0.784923632169367	ORAI1/ATF4/CREB3/POMC/CYP11A1/CALM1/SCARB1/PLCB2/ADCY2	-0.779073725764366
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/1097	14/9376	0.610496158353952	B4GALT2	-0.530873999574037
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	20/1097	203/9376	0.842063666695107	ACTN1/JUN/VEGFB/BAD/FLNB/PARVB/LAMC3/TLN1/ITGA6/HRAS/MYL12A/MYLK/ZYX/CAV2/RAC3/MYL5/SHC3/RAP1B/THBS1/COL4A4	-0.828083982023436
NA	NA	hsa03272	Virion - Hepatitis viruses	4/1097	48/9376	0.712245518079611	CD81/CD63/CLDN10/SCARB1	-0.727525897515279
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	6/1097	69/9376	0.743212714517855	MAP2K2/PLCG2/HRAS/MAPK12/PLA2G4C/RAC3	-0.779279434989714
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	6/1097	69/9376	0.743212714517855	GRIA4/JUN/ATF4/CREB3/TH/CALM1	-0.779279434989714
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	15/1097	157/9376	0.816587218180446	WNT2/RASSF1/BMP4/YWHAE/WNT5A/TGFB2/PRKCZ/AMOT/YWHAB/DLG4/TEAD4/BBC3/WNT2B/FZD10/PARD6B	-0.843601857376601
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	3/1097	38/9376	0.674758911864895	CD4/RFXANK/ORAI1	-0.73125740943594
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	10/1097	110/9376	0.776995110632303	HSP90AB1/ANAPC13/MAD2L2/CDC25B/MAPK12/ANAPC11/ANAPC2/CDK2/CDK1/ADCY2	-0.856376202529306
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	8/1097	91/9376	0.751379887204864	MAP2K2/JUN/NFKBIB/CD81/PLCG2/HRAS/RAC3/NFKBIE	-0.867493065735756
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	4/1097	50/9376	0.683755697356427	LTBR/CXCL12/HLA-DQB1/MADCAM1	-0.816131268707803
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	4/1097	50/9376	0.683755697356427	GYPC/CD81/TGFB2/THBS1	-0.816131268707803
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	17/1097	180/9376	0.807211587156892	BAX/BAD/CYCS/EIF4EBP1/TAPBPL/EIF2B1/BAK1/BID/CGAS/CARD9/SRSF9/SRSF3/IRAK1/SOCS3/TRAF2/C3/HLA-DQB1	-0.950643558744847
NA	NA	hsa04519	Cadherin signaling	41/1097	404/9376	0.86738810617616	WNT2/MAP2K2/ACTN1/ARPC5/ARPC5L/CDH3/VIM/PSENEN/LIMA1/KRT10/HRAS/ACTR3B/ARPC1B/MAPK12/RRAS/CIB2/YWHAE/WNT5A/ARPC3/MYO1E/AMOTL2/MRAS/RAC3/YWHAB/BRK1/LRP5/FGFR1/TEAD4/ARPC2/PCDHGA5/PCDHGA10/PCDHGC3/PCDHB4/WNT2B/DES/PCDHB7/PCDHGA3/PCDHB2/FZD10/PCDHB3/PSEN2	-0.991810126165653
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	7/1097	82/9376	0.729617359983992	HSP90AB1/CD4/HSPA8/RFXANK/HSPA2/TAPBPL/HLA-DQB1	-0.895126484524579
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	17/1097	181/9376	0.802751854631164	BAX/BAD/ATP6V0D1/CYCS/HSPD1/ATP6V0C/RFXANK/CTSD/MAPK12/TGFB2/BID/CARD9/IRAK1/CALM1/C3/SPHK1/HLA-DQB1	-0.975385645209852
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	9/1097	103/9376	0.746820543229107	JUN/GNA14/MAPK12/TGFB2/IRAK1/GNAL/PLCB2/C3/GNAO1	-0.940452698312635
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	5/1097	62/9376	0.689269856206075	RPS6KB2/HSPA8/HRAS/SOD1/ADCY2	-0.893534086604953
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	8/1097	93/9376	0.735221179953147	JUN/NFKBIB/CD4/MAPK12/NOTCH1/NFKBIE/HLA-DQB1/PRKCQ	-0.93407242683233
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	12/1097	133/9376	0.771153042131308	GRIA4/MAPK12/ATF4/CREB3/TH/GNG4/CALM1/ARRB2/GNAL/PLCB2/PPP2R5B/GNAO1	-0.967530129821906
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	3/1097	41/9376	0.625386308557707	POLD2/XRCC3/PALB2	-0.875020895105224
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	14/1097	154/9376	0.776995110632303	TPM1/TPM4/TPM2/MAPK12/ATF4/CREB3/CALM1/MYL3/PLCB2/PPP2R5B/ATP2A1/ADRA1D/ADCY2/ADRB1	-1.01569238685019
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/1097	30/9376	0.569796414463689	SLC19A1/SLC46A1	-0.859056593285011
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/1097	42/9376	0.610496158353952	CYP1B1/ECHS1/ALDH1B1	-0.920878859536001
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	6/1097	75/9376	0.683755697356427	GPX7/ATF4/CREB3/PLCB2/ADCY2/TSHR	-1.00089502447103
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	6/1097	76/9376	0.674758911864895	MYLK/SLC26A7/CALM1/PLCB2/GAST/ADCY2	-1.03626478022406
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	3/1097	43/9376	0.596298573275953	AGPAT2/SCARB1/PLPP2	-0.965792636367239
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	3/1097	44/9376	0.582746332974227	HSPD1/CPE/HLA-DQB1	-1.00980878834014
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	32/1097	333/9376	0.821328164992705	BAX/WNT2/MAP2K2/RPS6KB2/BAD/ATP6V0D1/LAMC3/EIF4EBP1/BCAP31/ATP6V0C/ITGA6/HRAS/TADA3/CDK4/ATP6V1F/BAK1/CREB3/HES6/WNT5A/PRKCZ/ATP6V1E2/ATP6V1B2/NOTCH4/ATP6V1G2/CDK2/THBS1/WNT2B/PPP2R5B/NOTCH1/FZD10/COL4A4/PARD6B	-1.20843128389787
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	14/1097	160/9376	0.747857793983592	CD4/CDH3/VSIR/ITGA6/ICAM3/CNTN1/NCAM2/PVR/CLDN10/ICAM2/SDC4/JAM2/HLA-DQB1/MADCAM1	-1.17093912419232
NA	NA	hsa04081	Hormone signaling	20/1097	219/9376	0.780543033511902	RAMP1/PTH1R/ADRA2C/IGF2/DIO2/GNA14/THRA/GNG4/RAMP2/POMC/VIPR2/PLCB2/OXT/GNAO1/GAST/ADRA1D/ADCY2/TSHR/PRL/ADRB1	-1.1961753065957
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	35/1097	362/9376	0.826362203296786	RPS6/HSP90AB1/MAP2K2/NGFR/VEGFB/RPS6KB2/FGF10/IGF2/BAD/LAMC3/EIF4EBP1/ITGA6/HRAS/CDK4/CDC37/G6PC3/MLST8/YWHAE/LPAR1/ATF4/CREB3/KITLG/EIF4E2/GNG4/YWHAB/FGFR1/ANGPT1/NTRK1/CDK2/THBS1/PPP2R5B/COL4A4/BCL2L11/NGF/PRL	-1.22642158506337
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	10/1097	122/9376	0.700569362045519	MAP2K2/JUN/NFKBIB/CD4/HRAS/CDK4/MAPK12/PPP2R5B/NFKBIE/PRKCQ	-1.21174549571857
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	14/1097	163/9376	0.734093540106593	BAX/MAP2K2/JUN/BAD/CYCS/HRAS/MAPK12/ATF4/CREB3/TGFB2/BID/IRAK1/YWHAB/CDK2	-1.24658577121723
Human Diseases	Substance dependence	hsa05032	Morphine addiction	7/1097	91/9376	0.657457401304256	PDE4D/GRK6/GNG4/GRK5/ARRB2/GNAO1/ADCY2	-1.19521033816166
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	17/1097	193/9376	0.752839822218863	NFKBIB/BAD/PLCG2/HRAS/GRK6/PRKCZ/GNG4/GRK5/RAC3/CXCL14/CXCL12/SHC3/ARRB2/RAP1B/PLCB2/RASGRP2/ADCY2	-1.26288810286787
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	11/1097	133/9376	0.706890288620366	MAP2K2/GADD45A/HRAS/G6PC3/DEPP1/MAPK12/TGFB2/GABARAPL2/CDK2/CDKN2B/BCL2L11	-1.23922327718212
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	4/1097	59/9376	0.579453980810531	MGLL/ADCY2/TSHR/ADRB1	-1.17950964127991
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	8/1097	103/9376	0.663840482870317	ACTN1/LAMC3/GNA14/TGFB2/SERPINB6/GNAL/PLCB2/COL4A4	-1.24868790296112
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	23/1097	254/9376	0.773936074763672	SLC25A6/VEGFB/FGF10/SLC25A5/PLCG2/VDAC1/GNA14/VDAC2/ORAI1/MYLK/ITPKA/CALM1/FGFR1/NTRK1/GNAL/PLCB2/SLC25A4/ATP2A1/SPHK1/ADRA1D/ADCY2/NGF/ADRB1	-1.32954517781871
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	5/1097	72/9376	0.593537931733009	NFKBIB/MAPK12/PIN1/TKFC/TRAF2	-1.2602346919259
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	3/1097	49/9376	0.523282421446245	B4GALT2/C1GALT1C1L/GALNT8	-1.21783437598572
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	15/1097	178/9376	0.720248276709719	SERPINF1/WNT2/JUN/SFRP1/RUVBL1/FRAT2/WNT5A/RAC3/LRP5/PORCN/PLCB2/TLE2/BAMBI/WNT2B/FZD10	-1.37162717135812
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/1097	37/9376	0.461997092808396	ADSL/RIMKLB	-1.19353540788078
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/1097	23/9376	0.371606357258927	ACY1	-1.09829813035531
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/1097	23/9376	0.371606357258927	KLK1	-1.09829813035531
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	6/1097	86/9376	0.596298573275953	SSPN/ITGA6/SGCE/DTNA/DES/ATP2A1	-1.3689943746455
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	4/1097	63/9376	0.54266325187018	KMT5A/ECHS1/ALDH1B1/HYKK	-1.32574983991732
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	8/1097	109/9376	0.627298804914153	HSP90AB1/JUN/NFKBIB/CD4/MAPK12/NFKBIE/HLA-DQB1/PRKCQ	-1.42463780056305
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	7/1097	99/9376	0.604329530491791	CFI/KRT10/C2/DEFB1/C3/CFD/HLA-DQB1	-1.44061345943561
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	4/1097	65/9376	0.525965921043405	MAP2K2/HRAS/ARRB2/PLCB2	-1.3959443025431
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	6/1097	89/9376	0.576198621367775	SLC38A5/GNG4/GABARAPL2/GNAO1/HAP1/ADCY2	-1.46224335481544
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	11/1097	144/9376	0.65289172490631	WNT2/MAP2K2/BMP4/HRAS/MAPK12/TBX3/WNT5A/FGFR1/ID4/WNT2B/FZD10	-1.52791194530366
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/1097	26/9376	0.328728700652128	PLA2G4C	-1.24761031933523
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/1097	26/9376	0.328728700652128	NKX6-1	-1.24761031933523
NA	NA	hsa04082	Neuroactive ligand signaling	16/1097	199/9376	0.6871916556346	GRIA4/ADRA2C/GNG4/POMC/P2RY1/OGFRL1/CHRNA3/GNAL/P2RY11/PLCB2/SLC1A1/GNAO1/GRIK2/ADRA1D/ADCY2/ADRB1	-1.6235082978477
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4/1097	68/9376	0.502761542173843	DHRS4L2/ADH1C/RDH13/DHRS3	-1.49792817822168
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	8/1097	115/9376	0.594570171614284	HRAS/ATF4/CREB3/GNG4/CHRNA3/PLCB2/GNAO1/ADCY2	-1.59233956548208
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	2/1097	44/9376	0.388497555316151	GTF2F1/TAF6L	-1.4799163950669
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	5/1097	83/9376	0.514876278129839	CBX6/CBX3/UBE2D4/L3MBTL2/EPOP	-1.61589672162391
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/1097	29/9376	0.294722283343287	CALM1	-1.38459593028685
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	8/1097	119/9376	0.574584619627249	JUN/MAPK12/ATF4/CREB3/RPS6KA4/SOCS3/TRAF2/MAP3K5	-1.70001027680641
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/1097	30/9376	0.284898207231844	PLA2G4C	-1.42795860053464
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	10/1097	144/9376	0.593537931733009	ACADVL/C2/MAPK12/LPIN3/ADH1C/ALDH1B1/IRAK1/MLYCD/MAP3K5/C3	-1.78917730857998
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/1097	48/9376	0.356122759039806	G6PC3/PLCB2	-1.62790641693229
Human Diseases	Immune disease	hsa05310	Asthma	1/1097	32/9376	0.267092069279854	HLA-DQB1	-1.51167352187607
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	11/1097	157/9376	0.59883062666566	MAP2K2/GAS6/NR1H2/ATP8A2/UQCRFS1/MAPK12/MFGE8/THBS1/ATP2A1/PTGER2/SPHK1	-1.84516708764828
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	6/1097	100/9376	0.51281677301732	CD4/CD59/ITGA6/KITLG/IL11RA/HLA-DQB1	-1.78283835405469
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	5/1097	89/9376	0.480165517806479	LAMC3/ITGA6/SDC4/THBS1/COL4A4	-1.79358670244213
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	14/1097	195/9376	0.613626907883973	MAP2K2/SLC25A6/SLC25A5/PLCG2/CYBA/VDAC1/VDAC2/GSDMD/MAPK12/HDAC11/HDAC10/PLCB2/SLC25A4/C3	-1.98462837452536
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	3/1097	66/9376	0.388497555316151	JUN/TGFB2/HLA-DQB1	-1.81466028944712
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	5/1097	94/9376	0.45462479877422	HSP90AB1/JUN/MAPK12/JUND/TRAF2	-1.9343655172536
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/1097	37/9376	0.230998546404198	PLCB2	-1.70599536045165
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/1097	54/9376	0.316553563590938	HLA-DQB1/TSHR	-1.83335608645205
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	8/1097	133/9376	0.514102028087539	MAP2K2/PLCG2/HRAS/BID/RAC3/SHC3/ICAM2/MICA	-2.05430271926276
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	30/1097	370/9376	0.692995639212595	GRIA4/PTH1R/ADRA2C/GAL/TMEM97/THRA/LPAR1/POMC/P2RY1/OGFRL1/NMB/QRFPR/F2RL2/VIPR2/CHRNA3/P2RY11/EDN3/NPW/OXT/C3/GRID1/ADM/GRIK2/PTGER2/NPB/ADRA1D/TSHR/PRL/CHRNE/ADRB1	-2.19320610335851
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/1097	38/9376	0.224919637288298	HSD11B2	-1.7426557677294
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	7/1097	122/9376	0.490398553431863	RPS6KB2/RAB11B/EIF4EBP1/G6PC3/CREB3/MLYCD/PPP2R5B	-2.06227145528268
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/1097	39/9376	0.219152467101419	HLA-DQB1	-1.7786679407339
Organismal Systems	Sensory system	hsa04742	Taste transduction	4/1097	86/9376	0.397532382183969	ENTPD2/P2RY1/PLCB2/TAS2R1	-2.04303161965292
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/1097	41/9376	0.208462102852569	GRIA4	-1.84887049003745
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	5/1097	102/9376	0.418967951811536	BST1/RAP1B/PLCB2/ATP2A1/ADCY2	-2.14766548847268
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	6/1097	115/9376	0.445927628710713	HRAS/PLA2G4C/GNG4/CYP4X1/PLCB2/GNAO1	-2.17613825420126
Organismal Systems	Digestive system	hsa04976	Bile secretion	4/1097	90/9376	0.379864276309126	EPHX1/SLC27A5/SCARB1/ADCY2	-2.15175923660892
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	8/1097	143/9376	0.478150837312186	SNRPD1/ACTN1/SNRPD3/C2/SNRPB/C6/C3/HLA-DQB1	-2.28897791591686
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	10/1097	168/9376	0.508746798628294	FHL1/PIM1/HRAS/SOCS2/SOCS1/SOCS3/CNTFR/IL11RA/CTF1/PRL	-2.33871547761386
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/1097	45/9376	0.189932138154563	HLA-DQB1	-1.98272998920744
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	5/1097	109/9376	0.392061753071346	MAP2K2/JUN/CTSK/MAPK12/IRAK1	-2.32382353049096
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	4/1097	100/9376	0.341877848678213	LTBR/TNFRSF10D/CXCL14/CXCL12	-2.40838630733725
Human Diseases	Substance dependence	hsa05034	Alcoholism	11/1097	191/9376	0.492232504641407	HRAS/ATF4/CREB3/TH/GNG4/CALM1/HDAC11/HDAC10/SLC29A3/SHC3/GNAO1	-2.58072667102013
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	11/1097	201/9376	0.467743325306013	BAX/HOXA11/NGFR/GADD45A/NUPR1/NFKBIZ/BAK1/HOXA9/SUPT3H/NTRK1/RUNX2	-2.77661790128129
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	18/1097	298/9376	0.516258496326161	NGFR/CD4/ACVRL1/LTBR/BMP4/TNFRSF10D/TNFSF12/IL32/TGFB2/CXCL14/CXCL12/TNFRSF12A/IL1RL1/CNTFR/IL11RA/CTF1/NGF/PRL	-3.08906042618268
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	18/1097	323/9376	0.47630040837522	CYP1B1/MAP2K2/TPM1/RASSF1/PLCG2/VIM/PIM1/HRAS/CDC25B/BAK1/TGFB2/CDKN2A/PDCD4/SOCS1/NOTCH4/THBS1/NOTCH1/BCL2L11	-3.4864805512999
NA	NA	hsa04382	Cornified envelope formation	7/1097	217/9376	0.27570794248243	S100A13/KAZN/KRT10/ITGA6/CLDN10/PPP2R5B/COL4A4	-3.92933965277578
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	3/1097	449/9376	0.0571065448794343	CALM1/ARRB2/GNAL	-7.45303284254808