ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003735 structural constituent of ribosome 89/2274 175/18639 0.508571428571429 4.1685412740294 6.86152392063775e-36 8.3985052788606e-33 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 31/2274 68/18639 0.455882352941176 3.73667158156138 8.8688896004958e-12 5.42776043550343e-09 GO:0019843 rRNA binding 29/2274 65/18639 0.446153846153846 3.65693119545362 7.96046526463437e-11 2.78687527294447e-08 GO:0009055 electron transfer activity 41/2274 116/18639 0.353448275862069 2.89706350650532 9.10743553249828e-11 2.78687527294447e-08 GO:0015078 proton transmembrane transporter activity 53/2274 185/18639 0.286486486486487 2.34820651786351 1.3521371693014e-09 3.31003179044982e-07 GO:0022853 active monoatomic ion transmembrane transporter activity 37/2274 118/18639 0.313559322033898 2.57011090738339 3.03571671787259e-08 6.19286210446008e-06 GO:0003954 NADH dehydrogenase activity 20/2274 44/18639 0.454545454545455 3.72571360038378 4.66194775607826e-08 8.15174864777112e-06 GO:0008137 NADH dehydrogenase (ubiquinone) activity 19/2274 41/18639 0.463414634146341 3.79841045112298 6.8695891507902e-08 1.0510471400709e-05 GO:1990948 ubiquitin ligase inhibitor activity 9/2274 11/18639 0.818181818181818 6.70628448069081 2.57654410439609e-07 3.50409998197868e-05 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 22/2274 58/18639 0.379310344827586 3.10904376307888 4.97480347217211e-07 6.08915944993866e-05 GO:0055105 ubiquitin-protein transferase inhibitor activity 10/2274 15/18639 0.666666666666667 5.46437994722955 1.20223702605372e-06 0.00013377619271725 GO:0015399 primary active transmembrane transporter activity 42/2274 166/18639 0.253012048192771 2.07383094382808 2.60061218944574e-06 0.000265262443323465 GO:0016651 oxidoreductase activity, acting on NAD(P)H 27/2274 88/18639 0.306818181818182 2.51485668025905 3.43218869098358e-06 0.000323153765981839 GO:0030515 snoRNA binding 14/2274 32/18639 0.4375 3.58599934036939 8.56010256059509e-06 0.000748397538154885 GO:0016853 isomerase activity 43/2274 180/18639 0.238888888888889 1.95806948109059 9.66830047748465e-06 0.000788933318962748 GO:0008135 translation factor activity, RNA binding 23/2274 83/18639 0.27710843373494 2.27133865276409 0.000104998950362319 0.0079655950190491 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 30/2274 122/18639 0.245901639344262 2.01554998053549 0.000116675945805959 0.0079655950190491 GO:0016860 intramolecular oxidoreductase activity 17/2274 53/18639 0.320754716981132 2.62908846517648 0.00011714110322131 0.0079655950190491 GO:0180051 translation factor activity 23/2274 84/18639 0.273809523809524 2.24429890689785 0.000128100156928557 0.00825234695160807 GO:0043022 ribosome binding 28/2274 112/18639 0.25 2.04914248021108 0.000143390101178431 0.00877547419211998 GO:0043021 ribonucleoprotein complex binding 39/2274 177/18639 0.220338983050847 1.806023880864 0.000160530483899178 0.00935663391869495 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 31/2274 132/18639 0.234848484848485 1.92495202686496 0.000222302215641134 0.0123680869065795 GO:0051082 unfolded protein binding 29/2274 121/18639 0.239669421487603 1.96446717111145 0.000241752208793653 0.0124676089306882 GO:0016675 oxidoreductase activity, acting on a heme group of donors 8/2274 16/18639 0.5 4.09828496042216 0.000251510345705637 0.0124676089306882 GO:0051540 metal cluster binding 21/2274 77/18639 0.272727272727273 2.23542816023027 0.000262733242589623 0.0124676089306882 GO:0031625 ubiquitin protein ligase binding 58/2274 302/18639 0.19205298013245 1.57417568016216 0.000284278341951834 0.0124676089306882 GO:0008173 RNA methyltransferase activity 19/2274 67/18639 0.283582089552239 2.32440042531406 0.000294510572544725 0.0124676089306882 GO:0044389 ubiquitin-like protein ligase binding 61/2274 322/18639 0.18944099378882 1.5527663514643 0.000294513561828446 0.0124676089306882 GO:0051087 protein-folding chaperone binding 31/2274 134/18639 0.23134328358209 1.89622139959831 0.000295392695253234 0.0124676089306882 GO:0008175 tRNA methyltransferase activity 12/2274 34/18639 0.352941176470588 2.89290703088623 0.000434923452690656 0.0169770927351497 GO:0043295 glutathione binding 6/2274 10/18639 0.6 4.9179419525066 0.000443845561703261 0.0169770927351497 GO:0097177 mitochondrial ribosome binding 6/2274 10/18639 0.6 4.9179419525066 0.000443845561703261 0.0169770927351497 GO:0044183 protein folding chaperone 20/2274 75/18639 0.266666666666667 2.18575197889182 0.000501943367165023 0.0186175358003027 GO:0051536 iron-sulfur cluster binding 20/2274 76/18639 0.263157894736842 2.15699208443272 0.000604231660105399 0.0217523397637944 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 17/2274 61/18639 0.278688524590164 2.28428997794022 0.000750167883828894 0.0262344425659019 GO:0055106 ubiquitin-protein transferase regulator activity 12/2274 36/18639 0.333333333333333 2.73218997361478 0.000786431094310406 0.0267386572065538 GO:0003743 translation initiation factor activity 15/2274 51/18639 0.294117647058824 2.41075585907186 0.000818753903144962 0.0270852642553901 GO:0034511 U3 snoRNA binding 6/2274 11/18639 0.545454545454545 4.47085632046054 0.000875587225800072 0.0274799683174176 GO:1900750 oligopeptide binding 6/2274 11/18639 0.545454545454545 4.47085632046054 0.000875587225800072 0.0274799683174176 GO:0004129 cytochrome-c oxidase activity 7/2274 15/18639 0.466666666666667 3.82506596306069 0.00105022369716333 0.0306065191744742 GO:0031386 protein tag activity 7/2274 15/18639 0.466666666666667 3.82506596306069 0.00105022369716333 0.0306065191744742 GO:0141047 molecular tag activity 7/2274 15/18639 0.466666666666667 3.82506596306069 0.00105022369716333 0.0306065191744742 GO:0051537 2 iron, 2 sulfur cluster binding 10/2274 28/18639 0.357142857142857 2.92734640030155 0.00116927859538945 0.0332836511803882 GO:0048027 mRNA 5'-UTR binding 9/2274 24/18639 0.375 3.07371372031662 0.00138057854897387 0.0384051850896367 GO:0051287 NAD binding 15/2274 54/18639 0.277777777777778 2.27682497801231 0.0015603716540038 0.0424421089889033 GO:0005525 GTP binding 66/2274 378/18639 0.174603174603175 1.43114712903631 0.00163659267343924 0.0435475963541224 GO:0031072 heat shock protein binding 28/2274 131/18639 0.213740458015267 1.75193860903543 0.00204819306944379 0.0533401769574297 GO:0032977 membrane insertase activity 7/2274 17/18639 0.411764705882353 3.3750582027006 0.00254440433201466 0.0648823104663738 GO:0019001 guanyl nucleotide binding 68/2274 400/18639 0.17 1.39341688654354 0.0027898434279166 0.0681383036500777 GO:0032561 guanyl ribonucleotide binding 68/2274 400/18639 0.17 1.39341688654354 0.0027898434279166 0.0681383036500777 GO:0004033 aldo-keto reductase (NADPH) activity 11/2274 36/18639 0.305555555555556 2.50450747581354 0.0028390959854199 0.0681383036500777 GO:0140098 catalytic activity, acting on RNA 66/2274 387/18639 0.170542635658915 1.39786463766337 0.00294910063698199 0.0694172919166531 GO:0045296 cadherin binding 58/2274 334/18639 0.173652694610778 1.42335645332027 0.00341024516487955 0.0785372442613181 GO:0016859 cis-trans isomerase activity 12/2274 42/18639 0.285714285714286 2.34187712024124 0.00346487842329344 0.0785372442613181 GO:0004090 carbonyl reductase (NADPH) activity 5/2274 10/18639 0.5 4.09828496042216 0.00398854166591635 0.0871781249836001 GO:0016868 intramolecular phosphotransferase activity 5/2274 10/18639 0.5 4.09828496042216 0.00398854166591635 0.0871781249836001 GO:0016741 transferase activity, transferring one-carbon groups 40/2274 215/18639 0.186046511627907 1.52494324108732 0.0041453838185016 0.089016663049929 GO:0008168 methyltransferase activity 38/2274 204/18639 0.186274509803922 1.52681204407885 0.00499788376525098 0.105472581528745 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 11/2274 39/18639 0.282051282051282 2.31185305459712 0.005614487669778 0.116476828945903 GO:0003924 GTPase activity 56/2274 331/18639 0.169184290030211 1.38673086274103 0.00686645201276141 0.138598274861932 GO:0140662 ATP-dependent protein folding chaperone 11/2274 40/18639 0.275 2.25405672823219 0.00690726696615838 0.138598274861932 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 7/2274 20/18639 0.35 2.86879947229551 0.00729384255619354 0.143396078604461 GO:0016504 peptidase activator activity 14/2274 57/18639 0.245614035087719 2.0131926121372 0.00738068051640608 0.143396078604461 GO:0008106 alcohol dehydrogenase (NADP+) activity 9/2274 30/18639 0.3 2.4589709762533 0.00767456415990204 0.146776039558126 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 13/2274 52/18639 0.25 2.04914248021108 0.00826401223877966 0.155617707388712 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 10/2274 36/18639 0.277777777777778 2.27682497801231 0.00910686554793723 0.16392357986287 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 10/2274 36/18639 0.277777777777778 2.27682497801231 0.00910686554793723 0.16392357986287 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 10/2274 36/18639 0.277777777777778 2.27682497801231 0.00910686554793723 0.16392357986287 GO:0140296 general transcription initiation factor binding 13/2274 53/18639 0.245283018867925 2.01047941454672 0.00975571457508992 0.17305789333203 GO:0008157 protein phosphatase 1 binding 8/2274 26/18639 0.307692307692308 2.52202151410595 0.00997116421647583 0.174352928585235 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 31/2274 167/18639 0.18562874251497 1.52151896734236 0.0109822642329349 0.18932804818468 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 6/2274 17/18639 0.352941176470588 2.89290703088623 0.0122731679318143 0.202406315885495 GO:0048038 quinone binding 6/2274 17/18639 0.352941176470588 2.89290703088623 0.0122731679318143 0.202406315885495 GO:0051787 misfolded protein binding 6/2274 17/18639 0.352941176470588 2.89290703088623 0.0122731679318143 0.202406315885495 GO:0004364 glutathione transferase activity 8/2274 27/18639 0.296296296296296 2.4286133098798 0.0126857307183447 0.202406315885495 GO:0072341 modified amino acid binding 19/2274 91/18639 0.208791208791209 1.71137174171475 0.0127510164248032 0.202406315885495 GO:0034062 5'-3' RNA polymerase activity 7/2274 22/18639 0.318181818181818 2.60799952026865 0.0128984416985855 0.202406315885495 GO:0097747 RNA polymerase activity 7/2274 22/18639 0.318181818181818 2.60799952026865 0.0128984416985855 0.202406315885495 GO:0016209 antioxidant activity 18/2274 86/18639 0.209302325581395 1.71556114622323 0.0147074222265222 0.227639773266957 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 5/2274 13/18639 0.384615384615385 3.15252689263243 0.0148784165533959 0.227639773266957 GO:0046625 sphingolipid binding 8/2274 28/18639 0.285714285714286 2.34187712024124 0.0159042247250818 0.231319055912581 GO:0033218 amide binding 42/2274 247/18639 0.17004048582996 1.3937487314796 0.0160061354732518 0.231319055912581 GO:1901681 sulfur compound binding 46/2274 275/18639 0.167272727272727 1.37106260494123 0.0160870075692443 0.231319055912581 GO:0031690 adrenergic receptor binding 6/2274 18/18639 0.333333333333333 2.73218997361478 0.0165451097187095 0.231319055912581 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 6/2274 18/18639 0.333333333333333 2.73218997361478 0.0165451097187095 0.231319055912581 GO:0008171 O-methyltransferase activity 7/2274 23/18639 0.304347826086957 2.49460823677871 0.0166307817976365 0.231319055912581 GO:0017134 fibroblast growth factor binding 7/2274 23/18639 0.304347826086957 2.49460823677871 0.0166307817976365 0.231319055912581 GO:0140102 catalytic activity, acting on a rRNA 7/2274 23/18639 0.304347826086957 2.49460823677871 0.0166307817976365 0.231319055912581 GO:0016829 lyase activity 35/2274 200/18639 0.175 1.43439973614776 0.0174794517799915 0.240391561558534 GO:0008191 metalloendopeptidase inhibitor activity 5/2274 14/18639 0.357142857142857 2.92734640030155 0.0208603301134945 0.283700489543525 GO:0004857 enzyme inhibitor activity 65/2274 416/18639 0.15625 1.28071405013193 0.0212233764020538 0.285466073803449 GO:0097001 ceramide binding 6/2274 19/18639 0.315789473684211 2.58839050131926 0.0217396714944539 0.289232151187082 GO:0004860 protein kinase inhibitor activity 17/2274 84/18639 0.202380952380952 1.65882962683754 0.0237913331838466 0.313124643193852 GO:0001094 TFIID-class transcription factor complex binding 4/2274 10/18639 0.4 3.27862796833773 0.025277538826315 0.318966056942366 GO:0005528 FK506 binding 4/2274 10/18639 0.4 3.27862796833773 0.025277538826315 0.318966056942366 GO:0047429 nucleoside triphosphate diphosphatase activity 4/2274 10/18639 0.4 3.27862796833773 0.025277538826315 0.318966056942366 GO:0050815 phosphoserine residue binding 4/2274 10/18639 0.4 3.27862796833773 0.025277538826315 0.318966056942366 GO:0008307 structural constituent of muscle 10/2274 42/18639 0.238095238095238 1.9515642668677 0.0268336165356471 0.335146394281959 GO:0017069 snRNA binding 12/2274 54/18639 0.222222222222222 1.82145998240985 0.0271646332529843 0.33516889247307 GO:0016835 carbon-oxygen lyase activity 16/2274 79/18639 0.20253164556962 1.66006479409505 0.0275634516748846 0.33516889247307 GO:0016505 peptidase activator activity involved in apoptotic process 6/2274 20/18639 0.3 2.4589709762533 0.0279307410394225 0.33516889247307 GO:0043024 ribosomal small subunit binding 6/2274 20/18639 0.3 2.4589709762533 0.0279307410394225 0.33516889247307 GO:0051371 muscle alpha-actinin binding 5/2274 15/18639 0.333333333333333 2.73218997361478 0.0282147596149474 0.335289958919375 GO:0005112 Notch binding 7/2274 26/18639 0.269230769230769 2.2067688248427 0.0322588688037214 0.376046242054809 GO:0008198 ferrous iron binding 7/2274 26/18639 0.269230769230769 2.2067688248427 0.0322588688037214 0.376046242054809 GO:0004519 endonuclease activity 23/2274 127/18639 0.181102362204724 1.4844181746411 0.0333413769332256 0.384998541191209 GO:0016790 thiolester hydrolase activity 10/2274 44/18639 0.227272727272727 1.86285680019189 0.0361887939141508 0.413972745335706 GO:0008142 oxysterol binding 5/2274 16/18639 0.3125 2.56142810026385 0.0370217018666067 0.419579287821543 GO:0023026 MHC class II protein complex binding 7/2274 27/18639 0.259259259259259 2.12503664614483 0.0391094671336031 0.43917419973881 GO:0019838 growth factor binding 24/2274 136/18639 0.176470588235294 1.44645351544312 0.0396286490856666 0.440958786189599 GO:0030544 Hsp70 protein binding 11/2274 51/18639 0.215686274509804 1.76788762998603 0.0409268404388183 0.451301375649672 GO:0016776 phosphotransferase activity, phosphate group as acceptor 9/2274 39/18639 0.230769230769231 1.89151613557946 0.0417692788554277 0.452438914327818 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 9/2274 39/18639 0.230769230769231 1.89151613557946 0.0417692788554277 0.452438914327818 GO:0019210 kinase inhibitor activity 17/2274 90/18639 0.188888888888889 1.54824098504837 0.0433426530993534 0.459375178910572 GO:0008649 rRNA methyltransferase activity 6/2274 22/18639 0.272727272727273 2.23542816023027 0.0435355561712633 0.459375178910572 GO:0061133 endopeptidase activator activity 6/2274 22/18639 0.272727272727273 2.23542816023027 0.0435355561712633 0.459375178910572 GO:0005080 protein kinase C binding 11/2274 52/18639 0.211538461538462 1.73388979094784 0.0464014636591326 0.467215833709578 GO:0016866 intramolecular transferase activity 7/2274 28/18639 0.25 2.04914248021108 0.0468445479364436 0.467215833709578 GO:0097718 disordered domain specific binding 7/2274 28/18639 0.25 2.04914248021108 0.0468445479364436 0.467215833709578 GO:0004550 nucleoside diphosphate kinase activity 5/2274 17/18639 0.294117647058824 2.41075585907186 0.0473335910061035 0.467215833709578 GO:0008429 phosphatidylethanolamine binding 5/2274 17/18639 0.294117647058824 2.41075585907186 0.0473335910061035 0.467215833709578 GO:0070492 oligosaccharide binding 5/2274 17/18639 0.294117647058824 2.41075585907186 0.0473335910061035 0.467215833709578 GO:0030291 protein serine/threonine kinase inhibitor activity 10/2274 46/18639 0.217391304347826 1.78186302627051 0.0475911248821253 0.467215833709578 GO:0160215 deacylase activity 13/2274 65/18639 0.2 1.63931398416887 0.0482056561339469 0.467215833709578 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 9/2274 40/18639 0.225 1.84422823218997 0.0482796265590026 0.467215833709578 GO:0005527 macrolide binding 4/2274 12/18639 0.333333333333333 2.73218997361478 0.0488591721526356 0.467215833709578 GO:0016423 tRNA (guanine) methyltransferase activity 4/2274 12/18639 0.333333333333333 2.73218997361478 0.0488591721526356 0.467215833709578 GO:0016840 carbon-nitrogen lyase activity 4/2274 12/18639 0.333333333333333 2.73218997361478 0.0488591721526356 0.467215833709578 GO:0004602 glutathione peroxidase activity 6/2274 23/18639 0.260869565217391 2.13823563152461 0.0530313588913669 0.499310640638716 GO:0099186 structural constituent of postsynapse 6/2274 23/18639 0.260869565217391 2.13823563152461 0.0530313588913669 0.499310640638716 GO:0003746 translation elongation factor activity 5/2274 18/18639 0.277777777777778 2.27682497801231 0.0591753145781782 0.536227107950769 GO:0016854 racemase and epimerase activity 5/2274 18/18639 0.277777777777778 2.27682497801231 0.0591753145781782 0.536227107950769 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 5/2274 18/18639 0.277777777777778 2.27682497801231 0.0591753145781782 0.536227107950769 GO:1901611 phosphatidylglycerol binding 5/2274 18/18639 0.277777777777778 2.27682497801231 0.0591753145781782 0.536227107950769 GO:0140104 molecular carrier activity 39/2274 249/18639 0.156626506024096 1.28380010808405 0.0603236586450743 0.536227107950769 GO:0004520 DNA endonuclease activity 9/2274 42/18639 0.214285714285714 1.75640784018093 0.0632245813737853 0.536227107950769 GO:0051879 Hsp90 protein binding 9/2274 42/18639 0.214285714285714 1.75640784018093 0.0632245813737853 0.536227107950769 GO:0001091 RNA polymerase II general transcription initiation factor binding 6/2274 24/18639 0.25 2.04914248021108 0.0636866488628664 0.536227107950769 GO:0042625 ATPase-coupled ion transmembrane transporter activity 6/2274 24/18639 0.25 2.04914248021108 0.0636866488628664 0.536227107950769 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 6/2274 24/18639 0.25 2.04914248021108 0.0636866488628664 0.536227107950769 GO:0046961 proton-transporting ATPase activity, rotational mechanism 6/2274 24/18639 0.25 2.04914248021108 0.0636866488628664 0.536227107950769 GO:0070300 phosphatidic acid binding 6/2274 24/18639 0.25 2.04914248021108 0.0636866488628664 0.536227107950769 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 4/2274 13/18639 0.307692307692308 2.52202151410595 0.0639617301967421 0.536227107950769 GO:0019104 DNA N-glycosylase activity 4/2274 13/18639 0.307692307692308 2.52202151410595 0.0639617301967421 0.536227107950769 GO:0045159 myosin II binding 4/2274 13/18639 0.307692307692308 2.52202151410595 0.0639617301967421 0.536227107950769 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 4/2274 13/18639 0.307692307692308 2.52202151410595 0.0639617301967421 0.536227107950769 GO:0044325 transmembrane transporter binding 23/2274 136/18639 0.169117647058824 1.38618461896632 0.0648153091593778 0.539686655857677 GO:0048156 tau protein binding 9/2274 43/18639 0.209302325581395 1.71556114622323 0.0716842556723412 0.584860963756269 GO:0051015 actin filament binding 33/2274 209/18639 0.157894736842105 1.29419525065963 0.0720012540678373 0.584860963756269 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 5/2274 19/18639 0.263157894736842 2.15699208443272 0.0725451871080798 0.584860963756269 GO:0005520 insulin-like growth factor binding 5/2274 19/18639 0.263157894736842 2.15699208443272 0.0725451871080798 0.584860963756269 GO:0046906 tetrapyrrole binding 25/2274 152/18639 0.164473684210526 1.34812005277045 0.0733289593763144 0.584860963756269 GO:0019208 phosphatase regulator activity 20/2274 117/18639 0.170940170940171 1.40112306339219 0.0739780907640881 0.584860963756269 GO:0019213 deacetylase activity 8/2274 37/18639 0.216216216216216 1.77223133423661 0.0740632756390699 0.584860963756269 GO:0023023 MHC protein complex binding 8/2274 37/18639 0.216216216216216 1.77223133423661 0.0740632756390699 0.584860963756269 GO:0003724 RNA helicase activity 14/2274 77/18639 0.181818181818182 1.49028544015351 0.0811566988696631 0.615882968899251 GO:0004601 peroxidase activity 11/2274 57/18639 0.192982456140351 1.58179419525066 0.0811693812158056 0.615882968899251 GO:0008474 palmitoyl-(protein) hydrolase activity 4/2274 14/18639 0.285714285714286 2.34187712024124 0.0812022902300411 0.615882968899251 GO:0032036 myosin heavy chain binding 4/2274 14/18639 0.285714285714286 2.34187712024124 0.0812022902300411 0.615882968899251 GO:0098599 palmitoyl hydrolase activity 4/2274 14/18639 0.285714285714286 2.34187712024124 0.0812022902300411 0.615882968899251 GO:1901612 cardiolipin binding 4/2274 14/18639 0.285714285714286 2.34187712024124 0.0812022902300411 0.615882968899251 GO:0061134 peptidase regulator activity 35/2274 226/18639 0.154867256637168 1.26938029747589 0.0815139223543126 0.615882968899251 GO:0031369 translation initiation factor binding 7/2274 32/18639 0.21875 1.7929996701847 0.0870142721373555 0.648472745553344 GO:0000339 RNA cap binding 5/2274 20/18639 0.25 2.04914248021108 0.0874166691309655 0.648472745553344 GO:0031418 L-ascorbic acid binding 5/2274 20/18639 0.25 2.04914248021108 0.0874166691309655 0.648472745553344 GO:0120014 phospholipid transfer activity 6/2274 26/18639 0.230769230769231 1.89151613557946 0.0884802915171651 0.652408896488012 GO:0051539 4 iron, 4 sulfur cluster binding 9/2274 45/18639 0.2 1.63931398416887 0.0906085330098216 0.664100864694741 GO:0020037 heme binding 23/2274 142/18639 0.161971830985915 1.32761343788324 0.0947499122500747 0.690320789250544 GO:0008186 ATP-dependent activity, acting on RNA 14/2274 79/18639 0.177215189873418 1.45255669483317 0.0959004220839829 0.694568737460326 GO:0019888 protein phosphatase regulator activity 18/2274 107/18639 0.168224299065421 1.37886222967475 0.097538518865308 0.702277335830217 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 11/2274 59/18639 0.186440677966102 1.52817405303877 0.0986671593735585 0.706249140779155 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 7/2274 33/18639 0.212121212121212 1.73866634684577 0.0993819893132982 0.706757881686923 GO:0004089 carbonate dehydratase activity 4/2274 15/18639 0.266666666666667 2.18575197889182 0.100470483180984 0.706757881686923 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 4/2274 15/18639 0.266666666666667 2.18575197889182 0.100470483180984 0.706757881686923 GO:0001671 ATPase activator activity 6/2274 27/18639 0.222222222222222 1.82145998240985 0.10258624134104 0.713440678417231 GO:0015252 proton channel activity 6/2274 27/18639 0.222222222222222 1.82145998240985 0.10258624134104 0.713440678417231 GO:0008373 sialyltransferase activity 5/2274 21/18639 0.238095238095238 1.9515642668677 0.103740634641612 0.717392863284368 GO:0019903 protein phosphatase binding 23/2274 144/18639 0.159722222222222 1.30917436235708 0.106446999085446 0.731972622924637 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 11/2274 60/18639 0.183333333333333 1.50270448548813 0.108193024252237 0.739028420053332 GO:0140597 protein carrier chaperone 29/2274 188/18639 0.154255319148936 1.26436450906641 0.108680650007843 0.739028420053332 GO:0004935 adrenergic receptor activity 3/2274 10/18639 0.3 2.4589709762533 0.112908338234244 0.739036395715051 GO:0005345 purine nucleobase transmembrane transporter activity 3/2274 10/18639 0.3 2.4589709762533 0.112908338234244 0.739036395715051 GO:0008140 cAMP response element binding protein binding 3/2274 10/18639 0.3 2.4589709762533 0.112908338234244 0.739036395715051 GO:0016427 tRNA (cytidine) methyltransferase activity 3/2274 10/18639 0.3 2.4589709762533 0.112908338234244 0.739036395715051 GO:0016889 DNA endonuclease activity, producing 3'-phosphomonoesters 3/2274 10/18639 0.3 2.4589709762533 0.112908338234244 0.739036395715051 GO:0030957 Tat protein binding 3/2274 10/18639 0.3 2.4589709762533 0.112908338234244 0.739036395715051 GO:0043121 neurotrophin binding 3/2274 10/18639 0.3 2.4589709762533 0.112908338234244 0.739036395715051 GO:0003925 G protein activity 10/2274 54/18639 0.185185185185185 1.51788331867488 0.115812663737576 0.75002486991954 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 10/2274 54/18639 0.185185185185185 1.51788331867488 0.115812663737576 0.75002486991954 GO:0016836 hydro-lyase activity 11/2274 61/18639 0.180327868852459 1.47806998572603 0.118231713828243 0.759504970356075 GO:0005201 extracellular matrix structural constituent 26/2274 168/18639 0.154761904761905 1.268516773464 0.119880694572952 0.759504970356075 GO:0140101 catalytic activity, acting on a tRNA 22/2274 139/18639 0.158273381294964 1.29729883639263 0.120660944225467 0.759504970356075 GO:0004407 histone deacetylase activity 5/2274 22/18639 0.227272727272727 1.86285680019189 0.121448010662303 0.759504970356075 GO:0033558 protein lysine deacetylase activity 5/2274 22/18639 0.227272727272727 1.86285680019189 0.121448010662303 0.759504970356075 GO:0030275 LRR domain binding 4/2274 16/18639 0.25 2.04914248021108 0.121620076952443 0.759504970356075 GO:0043023 ribosomal large subunit binding 4/2274 16/18639 0.25 2.04914248021108 0.121620076952443 0.759504970356075 GO:0016229 steroid dehydrogenase activity 7/2274 35/18639 0.2 1.63931398416887 0.126811058589597 0.784714542925221 GO:0140313 molecular sequestering activity 10/2274 55/18639 0.181818181818182 1.49028544015351 0.126939117237903 0.784714542925221 GO:0003712 transcription coregulator activity 69/2274 495/18639 0.139393939393939 1.14255217078436 0.130327549626115 0.801612667047061 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 6/2274 29/18639 0.206896551724138 1.69584205258848 0.134040303607098 0.812204611955881 GO:0043236 laminin binding 6/2274 29/18639 0.206896551724138 1.69584205258848 0.134040303607098 0.812204611955881 GO:0097472 cyclin-dependent protein kinase activity 6/2274 29/18639 0.206896551724138 1.69584205258848 0.134040303607098 0.812204611955881 GO:0060590 ATPase regulator activity 9/2274 49/18639 0.183673469387755 1.50549243444079 0.136373434527178 0.822271349070275 GO:0019212 phosphatase inhibitor activity 10/2274 56/18639 0.178571428571429 1.46367320015077 0.138621799701891 0.822364672982778 GO:0097110 scaffold protein binding 12/2274 70/18639 0.171428571428571 1.40512627214474 0.140240660747418 0.822364672982778 GO:0016849 phosphorus-oxygen lyase activity 5/2274 23/18639 0.217391304347826 1.78186302627051 0.14045263615423 0.822364672982778 GO:0010854 adenylate cyclase regulator activity 3/2274 11/18639 0.272727272727273 2.23542816023027 0.141763844770724 0.822364672982778 GO:0015205 nucleobase transmembrane transporter activity 3/2274 11/18639 0.272727272727273 2.23542816023027 0.141763844770724 0.822364672982778 GO:0015217 ADP transmembrane transporter activity 3/2274 11/18639 0.272727272727273 2.23542816023027 0.141763844770724 0.822364672982778 GO:0043522 leucine zipper domain binding 3/2274 11/18639 0.272727272727273 2.23542816023027 0.141763844770724 0.822364672982778 GO:0070990 snRNP binding 3/2274 11/18639 0.272727272727273 2.23542816023027 0.141763844770724 0.822364672982778 GO:0005092 GDP-dissociation inhibitor activity 4/2274 17/18639 0.235294117647059 1.92860468725749 0.144477457243625 0.830236655709845 GO:1990226 histone methyltransferase binding 4/2274 17/18639 0.235294117647059 1.92860468725749 0.144477457243625 0.830236655709845 GO:0008201 heparin binding 26/2274 172/18639 0.151162790697674 1.23901638338344 0.14569151264287 0.83330098820034 GO:0001965 G-protein alpha-subunit binding 6/2274 30/18639 0.2 1.63931398416887 0.151284643878357 0.84585672116072 GO:0001968 fibronectin binding 6/2274 30/18639 0.2 1.63931398416887 0.151284643878357 0.84585672116072 GO:0035925 mRNA 3'-UTR AU-rich region binding 6/2274 30/18639 0.2 1.63931398416887 0.151284643878357 0.84585672116072 GO:0098918 structural constituent of synapse 6/2274 30/18639 0.2 1.63931398416887 0.151284643878357 0.84585672116072 GO:0004536 DNA nuclease activity 11/2274 64/18639 0.171875 1.40878545514512 0.151342011384148 0.84585672116072 GO:0022829 wide pore channel activity 7/2274 37/18639 0.189189189189189 1.55070241745703 0.157620878769234 0.876945252788829 GO:0003714 transcription corepressor activity 30/2274 204/18639 0.147058823529412 1.20537792953593 0.160262608599107 0.884824006922635 GO:0015295 solute:proton symporter activity 5/2274 24/18639 0.208333333333333 1.70761873350923 0.16065421175722 0.884824006922635 GO:0019205 nucleobase-containing compound kinase activity 8/2274 44/18639 0.181818181818182 1.49028544015351 0.161205680999794 0.884824006922635 GO:0005539 glycosaminoglycan binding 35/2274 242/18639 0.144628099173554 1.18545432739484 0.162255883870345 0.886612508291531 GO:0005310 dicarboxylic acid transmembrane transporter activity 6/2274 31/18639 0.193548387096774 1.58643288790535 0.169455836164195 0.899676818840623 GO:0003779 actin binding 61/2274 443/18639 0.137697516930023 1.12864732544358 0.170996157907908 0.899676818840623 GO:0003995 acyl-CoA dehydrogenase activity 3/2274 12/18639 0.25 2.04914248021108 0.172732068976754 0.899676818840623 GO:0005165 neurotrophin receptor binding 3/2274 12/18639 0.25 2.04914248021108 0.172732068976754 0.899676818840623 GO:0008179 adenylate cyclase binding 3/2274 12/18639 0.25 2.04914248021108 0.172732068976754 0.899676818840623 GO:0017166 vinculin binding 3/2274 12/18639 0.25 2.04914248021108 0.172732068976754 0.899676818840623 GO:0031543 peptidyl-proline dioxygenase activity 3/2274 12/18639 0.25 2.04914248021108 0.172732068976754 0.899676818840623 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 3/2274 12/18639 0.25 2.04914248021108 0.172732068976754 0.899676818840623 GO:0097371 MDM2/MDM4 family protein binding 3/2274 12/18639 0.25 2.04914248021108 0.172732068976754 0.899676818840623 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 3/2274 12/18639 0.25 2.04914248021108 0.172732068976754 0.899676818840623 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 3/2274 12/18639 0.25 2.04914248021108 0.172732068976754 0.899676818840623 GO:0005178 integrin binding 24/2274 161/18639 0.149068322981366 1.22184893229978 0.174175536928647 0.899795159810527 GO:0004521 RNA endonuclease activity 12/2274 73/18639 0.164383561643836 1.34738135685112 0.174225043198607 0.899795159810527 GO:0001786 phosphatidylserine binding 10/2274 59/18639 0.169491525423729 1.38924913912616 0.176843205948578 0.905673991970958 GO:0031593 polyubiquitin modification-dependent protein binding 10/2274 59/18639 0.169491525423729 1.38924913912616 0.176843205948578 0.905673991970958 GO:0061135 endopeptidase regulator activity 27/2274 184/18639 0.146739130434783 1.20275754273259 0.178172487419955 0.908679685841772 GO:0000030 mannosyltransferase activity 5/2274 25/18639 0.2 1.63931398416887 0.181941235435316 0.91268882038044 GO:0017025 TBP-class protein binding 5/2274 25/18639 0.2 1.63931398416887 0.181941235435316 0.91268882038044 GO:0019211 phosphatase activator activity 5/2274 25/18639 0.2 1.63931398416887 0.181941235435316 0.91268882038044 GO:0047617 fatty acyl-CoA hydrolase activity 5/2274 25/18639 0.2 1.63931398416887 0.181941235435316 0.91268882038044 GO:0008378 galactosyltransferase activity 6/2274 32/18639 0.1875 1.53685686015831 0.188480812478082 0.934950722192289 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 6/2274 32/18639 0.1875 1.53685686015831 0.188480812478082 0.934950722192289 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 11/2274 67/18639 0.164179104477612 1.34570550939235 0.18867061142279 0.934950722192289 GO:0004864 protein phosphatase inhibitor activity 9/2274 53/18639 0.169811320754717 1.39187036391696 0.19189255273816 0.944863145377602 GO:0003756 protein disulfide isomerase activity 4/2274 19/18639 0.210526315789474 1.72559366754617 0.194530647577742 0.944863145377602 GO:0005346 purine ribonucleotide transmembrane transporter activity 4/2274 19/18639 0.210526315789474 1.72559366754617 0.194530647577742 0.944863145377602 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 4/2274 19/18639 0.210526315789474 1.72559366754617 0.194530647577742 0.944863145377602 GO:0120227 acyl-CoA binding 4/2274 19/18639 0.210526315789474 1.72559366754617 0.194530647577742 0.944863145377602 GO:0004518 nuclease activity 30/2274 209/18639 0.143540669856459 1.1765411369633 0.195398588164633 0.944979401607393 GO:0022804 active transmembrane transporter activity 62/2274 457/18639 0.135667396061269 1.11200729779507 0.201332590371147 0.944979401607393 GO:0005200 structural constituent of cytoskeleton 17/2274 112/18639 0.151785714285714 1.24412222012816 0.202249142657434 0.944979401607393 GO:0016289 acyl-CoA hydrolase activity 5/2274 26/18639 0.192307692307692 1.57626344631622 0.204193841130114 0.944979401607393 GO:0030247 polysaccharide binding 5/2274 26/18639 0.192307692307692 1.57626344631622 0.204193841130114 0.944979401607393 GO:0050750 low-density lipoprotein particle receptor binding 5/2274 26/18639 0.192307692307692 1.57626344631622 0.204193841130114 0.944979401607393 GO:0070412 R-SMAD binding 5/2274 26/18639 0.192307692307692 1.57626344631622 0.204193841130114 0.944979401607393 GO:0005542 folic acid binding 3/2274 13/18639 0.230769230769231 1.89151613557946 0.205363170610757 0.944979401607393 GO:0008035 high-density lipoprotein particle binding 3/2274 13/18639 0.230769230769231 1.89151613557946 0.205363170610757 0.944979401607393 GO:0008253 5'-nucleotidase activity 3/2274 13/18639 0.230769230769231 1.89151613557946 0.205363170610757 0.944979401607393 GO:0019855 calcium channel inhibitor activity 3/2274 13/18639 0.230769230769231 1.89151613557946 0.205363170610757 0.944979401607393 GO:0031994 insulin-like growth factor I binding 3/2274 13/18639 0.230769230769231 1.89151613557946 0.205363170610757 0.944979401607393 GO:0043560 insulin receptor substrate binding 3/2274 13/18639 0.230769230769231 1.89151613557946 0.205363170610757 0.944979401607393 GO:1901338 catecholamine binding 3/2274 13/18639 0.230769230769231 1.89151613557946 0.205363170610757 0.944979401607393 GO:0005504 fatty acid binding 8/2274 47/18639 0.170212765957447 1.39516083759052 0.208783615639104 0.957120395289377 GO:0017022 myosin binding 12/2274 76/18639 0.157894736842105 1.29419525065963 0.211790824691915 0.967283467995908 GO:0051117 ATPase binding 13/2274 84/18639 0.154761904761905 1.268516773464 0.22034440538792 0.999999999999997 GO:0030742 GTP-dependent protein binding 4/2274 20/18639 0.2 1.63931398416887 0.221309142189436 0.999999999999997 GO:0016874 ligase activity 24/2274 167/18639 0.143712574850299 1.17795016826505 0.224904452818641 0.999999999999997 GO:0008320 protein transmembrane transporter activity 5/2274 27/18639 0.185185185185185 1.51788331867488 0.227286477445813 0.999999999999997 GO:0008395 steroid hydroxylase activity 5/2274 27/18639 0.185185185185185 1.51788331867488 0.227286477445813 0.999999999999997 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 6/2274 34/18639 0.176470588235294 1.44645351544312 0.228771460575511 0.999999999999997 GO:0000287 magnesium ion binding 32/2274 230/18639 0.139130434782609 1.14039233681312 0.23881786445956 0.999999999999997 GO:0005347 ATP transmembrane transporter activity 3/2274 14/18639 0.214285714285714 1.75640784018093 0.239225228896407 0.999999999999997 GO:0008195 phosphatidate phosphatase activity 3/2274 14/18639 0.214285714285714 1.75640784018093 0.239225228896407 0.999999999999997 GO:0016530 metallochaperone activity 3/2274 14/18639 0.214285714285714 1.75640784018093 0.239225228896407 0.999999999999997 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 3/2274 14/18639 0.214285714285714 1.75640784018093 0.239225228896407 0.999999999999997 GO:0031404 chloride ion binding 3/2274 14/18639 0.214285714285714 1.75640784018093 0.239225228896407 0.999999999999997 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 3/2274 14/18639 0.214285714285714 1.75640784018093 0.239225228896407 0.999999999999997 GO:0016763 pentosyltransferase activity 8/2274 49/18639 0.163265306122449 1.33821549728071 0.243185450179343 0.999999999999997 GO:0005506 iron ion binding 22/2274 154/18639 0.142857142857143 1.17093856012062 0.245939098919189 0.999999999999997 GO:0009975 cyclase activity 4/2274 21/18639 0.19047619047619 1.56125141349416 0.248972320435982 0.999999999999997 GO:0072542 protein phosphatase activator activity 4/2274 21/18639 0.19047619047619 1.56125141349416 0.248972320435982 0.999999999999997 GO:0051393 alpha-actinin binding 5/2274 28/18639 0.178571428571429 1.46367320015077 0.251090380942626 0.999999999999997 GO:0005518 collagen binding 11/2274 72/18639 0.152777777777778 1.25225373790677 0.258853981647457 0.999999999999997 GO:0008081 phosphoric diester hydrolase activity 13/2274 87/18639 0.149425287356322 1.22477481575835 0.259643353420466 0.999999999999997 GO:0003713 transcription coactivator activity 35/2274 256/18639 0.13671875 1.12062479386544 0.260274051717624 0.999999999999997 GO:0008200 ion channel inhibitor activity 7/2274 43/18639 0.162790697674419 1.3343253359514 0.266491318155309 0.999999999999997 GO:0000774 adenyl-nucleotide exchange factor activity 3/2274 15/18639 0.2 1.63931398416887 0.273913915325262 0.999999999999997 GO:0004865 protein serine/threonine phosphatase inhibitor activity 3/2274 15/18639 0.2 1.63931398416887 0.273913915325262 0.999999999999997 GO:0008252 nucleotidase activity 3/2274 15/18639 0.2 1.63931398416887 0.273913915325262 0.999999999999997 GO:0015556 C4-dicarboxylate transmembrane transporter activity 3/2274 15/18639 0.2 1.63931398416887 0.273913915325262 0.999999999999997 GO:0016846 carbon-sulfur lyase activity 3/2274 15/18639 0.2 1.63931398416887 0.273913915325262 0.999999999999997 GO:0031005 filamin binding 3/2274 15/18639 0.2 1.63931398416887 0.273913915325262 0.999999999999997 GO:0033130 acetylcholine receptor binding 3/2274 15/18639 0.2 1.63931398416887 0.273913915325262 0.999999999999997 GO:0050780 dopamine receptor binding 3/2274 15/18639 0.2 1.63931398416887 0.273913915325262 0.999999999999997 GO:0035250 UDP-galactosyltransferase activity 5/2274 29/18639 0.172413793103448 1.4132017104904 0.275475813720861 0.999999999999997 GO:0016881 acid-amino acid ligase activity 4/2274 22/18639 0.181818181818182 1.49028544015351 0.277311055941244 0.999999999999997 GO:0031683 G-protein beta/gamma-subunit complex binding 4/2274 22/18639 0.181818181818182 1.49028544015351 0.277311055941244 0.999999999999997 GO:0140517 protein-RNA adaptor activity 4/2274 22/18639 0.181818181818182 1.49028544015351 0.277311055941244 0.999999999999997 GO:0042826 histone deacetylase binding 18/2274 127/18639 0.141732283464567 1.16171857145825 0.28459693788147 0.999999999999997 GO:0016248 channel inhibitor activity 7/2274 44/18639 0.159090909090909 1.30399976013432 0.286410222482028 0.999999999999997 GO:0030020 extracellular matrix structural constituent conferring tensile strength 7/2274 44/18639 0.159090909090909 1.30399976013432 0.286410222482028 0.999999999999997 GO:0030547 signaling receptor inhibitor activity 7/2274 44/18639 0.159090909090909 1.30399976013432 0.286410222482028 0.999999999999997 GO:0003684 damaged DNA binding 11/2274 74/18639 0.148648648648649 1.21840904228767 0.289146261284121 0.999999999999997 GO:0042805 actinin binding 6/2274 37/18639 0.162162162162162 1.32917350067746 0.293514292462108 0.999999999999997 GO:0050840 extracellular matrix binding 10/2274 67/18639 0.149253731343284 1.22336864490214 0.297767766579401 0.999999999999997 GO:0016769 transferase activity, transferring nitrogenous groups 5/2274 30/18639 0.166666666666667 1.36609498680739 0.300314047689361 0.999999999999997 GO:0019003 GDP binding 11/2274 75/18639 0.146666666666667 1.2021635883905 0.30465759219778 0.999999999999997 GO:0004540 RNA nuclease activity 17/2274 121/18639 0.140495867768595 1.15158420375499 0.304829141625941 0.999999999999997 GO:0000295 adenine nucleotide transmembrane transporter activity 4/2274 23/18639 0.173913043478261 1.4254904210164 0.306123354843774 0.999999999999997 GO:0140103 catalytic activity, acting on a glycoprotein 4/2274 23/18639 0.173913043478261 1.4254904210164 0.306123354843774 0.999999999999997 GO:0141110 transporter inhibitor activity 7/2274 45/18639 0.155555555555556 1.2750219876869 0.306662381768272 0.999999999999997 GO:0001098 basal transcription machinery binding 9/2274 60/18639 0.15 1.22948548812665 0.306924647495045 0.999999999999997 GO:0001099 basal RNA polymerase II transcription machinery binding 9/2274 60/18639 0.15 1.22948548812665 0.306924647495045 0.999999999999997 GO:0000062 fatty-acyl-CoA binding 3/2274 16/18639 0.1875 1.53685686015831 0.309058647257451 0.999999999999997 GO:0005159 insulin-like growth factor receptor binding 3/2274 16/18639 0.1875 1.53685686015831 0.309058647257451 0.999999999999997 GO:0016722 oxidoreductase activity, acting on metal ions 3/2274 16/18639 0.1875 1.53685686015831 0.309058647257451 0.999999999999997 GO:0017070 U6 snRNA binding 3/2274 16/18639 0.1875 1.53685686015831 0.309058647257451 0.999999999999997 GO:0022841 potassium ion leak channel activity 3/2274 16/18639 0.1875 1.53685686015831 0.309058647257451 0.999999999999997 GO:0022858 alanine transmembrane transporter activity 3/2274 16/18639 0.1875 1.53685686015831 0.309058647257451 0.999999999999997 GO:0032934 sterol binding 10/2274 68/18639 0.147058823529412 1.20537792953593 0.314284625535542 0.999999999999997 GO:0005109 frizzled binding 6/2274 38/18639 0.157894736842105 1.29419525065963 0.315887723604519 0.999999999999997 GO:0042887 amide transmembrane transporter activity 6/2274 38/18639 0.157894736842105 1.29419525065963 0.315887723604519 0.999999999999997 GO:0043531 ADP binding 6/2274 38/18639 0.157894736842105 1.29419525065963 0.315887723604519 0.999999999999997 GO:0016878 acid-thiol ligase activity 5/2274 31/18639 0.161290322580645 1.32202740658779 0.325479088367278 0.999999999999997 GO:0070325 lipoprotein particle receptor binding 5/2274 31/18639 0.161290322580645 1.32202740658779 0.325479088367278 0.999999999999997 GO:0035035 histone acetyltransferase binding 4/2274 24/18639 0.166666666666667 1.36609498680739 0.335217183461085 0.999999999999997 GO:0050431 transforming growth factor beta binding 4/2274 24/18639 0.166666666666667 1.36609498680739 0.335217183461085 0.999999999999997 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 4/2274 24/18639 0.166666666666667 1.36609498680739 0.335217183461085 0.999999999999997 GO:0015485 cholesterol binding 8/2274 54/18639 0.148148148148148 1.2143066549399 0.335754458199419 0.999999999999997 GO:0004549 tRNA-specific ribonuclease activity 3/2274 17/18639 0.176470588235294 1.44645351544312 0.344326045117557 0.999999999999997 GO:0017110 nucleoside diphosphate phosphatase activity 3/2274 17/18639 0.176470588235294 1.44645351544312 0.344326045117557 0.999999999999997 GO:0030169 low-density lipoprotein particle binding 3/2274 17/18639 0.176470588235294 1.44645351544312 0.344326045117557 0.999999999999997 GO:0030548 acetylcholine receptor regulator activity 3/2274 17/18639 0.176470588235294 1.44645351544312 0.344326045117557 0.999999999999997 GO:1901567 fatty acid derivative binding 3/2274 17/18639 0.176470588235294 1.44645351544312 0.344326045117557 0.999999999999997 GO:0051219 phosphoprotein binding 13/2274 93/18639 0.139784946236559 1.14575708570942 0.344385754423831 0.999999999999997 GO:0000182 rDNA binding 2/2274 10/18639 0.2 1.63931398416887 0.349505711151536 0.999999999999997 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 2/2274 10/18639 0.2 1.63931398416887 0.349505711151536 0.999999999999997 GO:0004862 cAMP-dependent protein kinase inhibitor activity 2/2274 10/18639 0.2 1.63931398416887 0.349505711151536 0.999999999999997 GO:0008190 eukaryotic initiation factor 4E binding 2/2274 10/18639 0.2 1.63931398416887 0.349505711151536 0.999999999999997 GO:0015643 toxic substance binding 2/2274 10/18639 0.2 1.63931398416887 0.349505711151536 0.999999999999997 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 2/2274 10/18639 0.2 1.63931398416887 0.349505711151536 0.999999999999997 GO:0016783 sulfurtransferase activity 2/2274 10/18639 0.2 1.63931398416887 0.349505711151536 0.999999999999997 GO:0031419 cobalamin binding 2/2274 10/18639 0.2 1.63931398416887 0.349505711151536 0.999999999999997 GO:0031434 mitogen-activated protein kinase kinase binding 2/2274 10/18639 0.2 1.63931398416887 0.349505711151536 0.999999999999997 GO:0031957 very long-chain fatty acid-CoA ligase activity 2/2274 10/18639 0.2 1.63931398416887 0.349505711151536 0.999999999999997 GO:0031996 thioesterase binding 2/2274 10/18639 0.2 1.63931398416887 0.349505711151536 0.999999999999997 GO:0033204 ribonuclease P RNA binding 2/2274 10/18639 0.2 1.63931398416887 0.349505711151536 0.999999999999997 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 2/2274 10/18639 0.2 1.63931398416887 0.349505711151536 0.999999999999997 GO:0035374 chondroitin sulfate binding 2/2274 10/18639 0.2 1.63931398416887 0.349505711151536 0.999999999999997 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 2/2274 10/18639 0.2 1.63931398416887 0.349505711151536 0.999999999999997 GO:0043422 protein kinase B binding 2/2274 10/18639 0.2 1.63931398416887 0.349505711151536 0.999999999999997 GO:0070097 delta-catenin binding 2/2274 10/18639 0.2 1.63931398416887 0.349505711151536 0.999999999999997 GO:0070513 death domain binding 2/2274 10/18639 0.2 1.63931398416887 0.349505711151536 0.999999999999997 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 2/2274 10/18639 0.2 1.63931398416887 0.349505711151536 0.999999999999997 GO:0098505 G-rich strand telomeric DNA binding 2/2274 10/18639 0.2 1.63931398416887 0.349505711151536 0.999999999999997 GO:1905394 retromer complex binding 2/2274 10/18639 0.2 1.63931398416887 0.349505711151536 0.999999999999997 GO:0022884 macromolecule transmembrane transporter activity 5/2274 32/18639 0.15625 1.28071405013193 0.35084913945787 0.999999999999997 GO:0043425 bHLH transcription factor binding 5/2274 32/18639 0.15625 1.28071405013193 0.35084913945787 0.999999999999997 GO:0051059 NF-kappaB binding 5/2274 32/18639 0.15625 1.28071405013193 0.35084913945787 0.999999999999997 GO:0071813 lipoprotein particle binding 5/2274 32/18639 0.15625 1.28071405013193 0.35084913945787 0.999999999999997 GO:0071814 protein-lipid complex binding 5/2274 32/18639 0.15625 1.28071405013193 0.35084913945787 0.999999999999997 GO:0005507 copper ion binding 9/2274 63/18639 0.142857142857143 1.17093856012062 0.36049427652203 0.999999999999997 GO:0015036 disulfide oxidoreductase activity 6/2274 40/18639 0.15 1.22948548812665 0.361294509286589 0.999999999999997 GO:0050997 quaternary ammonium group binding 6/2274 40/18639 0.15 1.22948548812665 0.361294509286589 0.999999999999997 GO:0042974 nuclear retinoic acid receptor binding 4/2274 25/18639 0.16 1.31145118733509 0.364412602132659 0.999999999999997 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 7/2274 48/18639 0.145833333333333 1.19533311345646 0.368756372355081 0.999999999999997 GO:0016879 ligase activity, forming carbon-nitrogen bonds 7/2274 48/18639 0.145833333333333 1.19533311345646 0.368756372355081 0.999999999999997 GO:0004970 glutamate-gated receptor activity 3/2274 18/18639 0.166666666666667 1.36609498680739 0.379421354540032 0.999999999999997 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 3/2274 18/18639 0.166666666666667 1.36609498680739 0.379421354540032 0.999999999999997 GO:0034185 apolipoprotein binding 3/2274 18/18639 0.166666666666667 1.36609498680739 0.379421354540032 0.999999999999997 GO:0035615 clathrin adaptor activity 3/2274 18/18639 0.166666666666667 1.36609498680739 0.379421354540032 0.999999999999997 GO:0070628 proteasome binding 3/2274 18/18639 0.166666666666667 1.36609498680739 0.379421354540032 0.999999999999997 GO:0098641 cadherin binding involved in cell-cell adhesion 3/2274 18/18639 0.166666666666667 1.36609498680739 0.379421354540032 0.999999999999997 GO:0099602 neurotransmitter receptor regulator activity 3/2274 18/18639 0.166666666666667 1.36609498680739 0.379421354540032 0.999999999999997 GO:0016877 ligase activity, forming carbon-sulfur bonds 6/2274 41/18639 0.146341463414634 1.19949803719673 0.384158875427415 0.999999999999997 GO:0061650 ubiquitin-like protein conjugating enzyme activity 6/2274 41/18639 0.146341463414634 1.19949803719673 0.384158875427415 0.999999999999997 GO:0140318 protein transporter activity 6/2274 41/18639 0.146341463414634 1.19949803719673 0.384158875427415 0.999999999999997 GO:0000049 tRNA binding 11/2274 80/18639 0.1375 1.12702836411609 0.384690141324736 0.999999999999997 GO:0019887 protein kinase regulator activity 33/2274 255/18639 0.129411764705882 1.06073257799162 0.386100972004354 0.999999999999997 GO:0001222 transcription corepressor binding 7/2274 49/18639 0.142857142857143 1.17093856012062 0.389684859384371 0.999999999999997 GO:0005543 phospholipid binding 63/2274 497/18639 0.126760563380282 1.0390018209521 0.391866582560095 0.999999999999997 GO:0004435 phosphatidylinositol phospholipase C activity 4/2274 26/18639 0.153846153846154 1.26101075705297 0.393543285951304 0.999999999999997 GO:0015216 purine nucleotide transmembrane transporter activity 4/2274 26/18639 0.153846153846154 1.26101075705297 0.393543285951304 0.999999999999997 GO:0097602 cullin family protein binding 4/2274 26/18639 0.153846153846154 1.26101075705297 0.393543285951304 0.999999999999997 GO:0030246 carbohydrate binding 36/2274 280/18639 0.128571428571429 1.05384470410856 0.394562029383977 0.999999999999997 GO:0003689 DNA clamp loader activity 21/2274 160/18639 0.13125 1.07579980211082 0.395161349082496 0.999999999999997 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 2/2274 11/18639 0.181818181818182 1.49028544015351 0.395670570347272 0.999999999999997 GO:0000099 sulfur amino acid transmembrane transporter activity 2/2274 11/18639 0.181818181818182 1.49028544015351 0.395670570347272 0.999999999999997 GO:0003953 NAD+ nucleosidase activity 2/2274 11/18639 0.181818181818182 1.49028544015351 0.395670570347272 0.999999999999997 GO:0004016 adenylate cyclase activity 2/2274 11/18639 0.181818181818182 1.49028544015351 0.395670570347272 0.999999999999997 GO:0004523 RNA-DNA hybrid ribonuclease activity 2/2274 11/18639 0.181818181818182 1.49028544015351 0.395670570347272 0.999999999999997 GO:0005114 type II transforming growth factor beta receptor binding 2/2274 11/18639 0.181818181818182 1.49028544015351 0.395670570347272 0.999999999999997 GO:0008172 S-methyltransferase activity 2/2274 11/18639 0.181818181818182 1.49028544015351 0.395670570347272 0.999999999999997 GO:0008199 ferric iron binding 2/2274 11/18639 0.181818181818182 1.49028544015351 0.395670570347272 0.999999999999997 GO:0008432 JUN kinase binding 2/2274 11/18639 0.181818181818182 1.49028544015351 0.395670570347272 0.999999999999997 GO:0008526 phosphatidylinositol transfer activity 2/2274 11/18639 0.181818181818182 1.49028544015351 0.395670570347272 0.999999999999997 GO:0015173 aromatic amino acid transmembrane transporter activity 2/2274 11/18639 0.181818181818182 1.49028544015351 0.395670570347272 0.999999999999997 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 2/2274 11/18639 0.181818181818182 1.49028544015351 0.395670570347272 0.999999999999997 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 2/2274 11/18639 0.181818181818182 1.49028544015351 0.395670570347272 0.999999999999997 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 2/2274 11/18639 0.181818181818182 1.49028544015351 0.395670570347272 0.999999999999997 GO:0019215 intermediate filament binding 2/2274 11/18639 0.181818181818182 1.49028544015351 0.395670570347272 0.999999999999997 GO:0032050 clathrin heavy chain binding 2/2274 11/18639 0.181818181818182 1.49028544015351 0.395670570347272 0.999999999999997 GO:0032794 GTPase activating protein binding 2/2274 11/18639 0.181818181818182 1.49028544015351 0.395670570347272 0.999999999999997 GO:0048185 activin binding 2/2274 11/18639 0.181818181818182 1.49028544015351 0.395670570347272 0.999999999999997 GO:0070697 activin receptor binding 2/2274 11/18639 0.181818181818182 1.49028544015351 0.395670570347272 0.999999999999997 GO:0140031 phosphorylation-dependent protein binding 2/2274 11/18639 0.181818181818182 1.49028544015351 0.395670570347272 0.999999999999997 GO:0140537 transcription regulator activator activity 2/2274 11/18639 0.181818181818182 1.49028544015351 0.395670570347272 0.999999999999997 GO:0016887 ATP hydrolysis activity 53/2274 417/18639 0.127098321342926 1.04177027770923 0.396292501320536 0.999999999999997 GO:0015035 protein-disulfide reductase activity 5/2274 34/18639 0.147058823529412 1.20537792953593 0.401745118630669 0.999999999999997 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 5/2274 34/18639 0.147058823529412 1.20537792953593 0.401745118630669 0.999999999999997 GO:0030332 cyclin binding 5/2274 34/18639 0.147058823529412 1.20537792953593 0.401745118630669 0.999999999999997 GO:0016922 nuclear receptor binding 18/2274 137/18639 0.131386861313869 1.0769215954394 0.40635445817617 0.999999999999997 GO:0030414 peptidase inhibitor activity 22/2274 169/18639 0.130177514792899 1.06700910212175 0.406708951569331 0.999999999999997 GO:0004866 endopeptidase inhibitor activity 21/2274 161/18639 0.130434782608696 1.0691178157623 0.40671759507404 0.999999999999997 GO:0008408 3'-5' exonuclease activity 8/2274 58/18639 0.137931034482759 1.13056136839232 0.41317112801601 0.999999999999997 GO:0022840 leak channel activity 3/2274 19/18639 0.157894736842105 1.29419525065963 0.414088362095461 0.999999999999997 GO:0022842 narrow pore channel activity 3/2274 19/18639 0.157894736842105 1.29419525065963 0.414088362095461 0.999999999999997 GO:0042577 lipid phosphatase activity 3/2274 19/18639 0.157894736842105 1.29419525065963 0.414088362095461 0.999999999999997 GO:0050145 nucleoside monophosphate kinase activity 3/2274 19/18639 0.157894736842105 1.29419525065963 0.414088362095461 0.999999999999997 GO:0048029 monosaccharide binding 10/2274 74/18639 0.135135135135135 1.10764458389788 0.416340545035046 0.999999999999997 GO:0004497 monooxygenase activity 14/2274 106/18639 0.132075471698113 1.08256583860208 0.418785772534569 0.999999999999997 GO:0005385 zinc ion transmembrane transporter activity 4/2274 27/18639 0.148148148148148 1.2143066549399 0.422457513517476 0.999999999999997 GO:0035255 ionotropic glutamate receptor binding 4/2274 27/18639 0.148148148148148 1.2143066549399 0.422457513517476 0.999999999999997 GO:0000175 3'-5'-RNA exonuclease activity 5/2274 35/18639 0.142857142857143 1.17093856012062 0.427058185709313 0.999999999999997 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 6/2274 43/18639 0.13953488372093 1.14370743081549 0.429812281497313 0.999999999999997 GO:0004386 helicase activity 20/2274 155/18639 0.129032258064516 1.05762192527024 0.430459192322637 0.999999999999997 GO:0015459 potassium channel regulator activity 8/2274 59/18639 0.135593220338983 1.11139931130093 0.432574922730056 0.999999999999997 GO:0045309 protein phosphorylated amino acid binding 8/2274 59/18639 0.135593220338983 1.11139931130093 0.432574922730056 0.999999999999997 GO:0140297 DNA-binding transcription factor binding 61/2274 488/18639 0.125 1.02457124010554 0.439843510820604 0.999999999999997 GO:0000340 RNA 7-methylguanosine cap binding 2/2274 12/18639 0.166666666666667 1.36609498680739 0.440258270621376 0.999999999999997 GO:0004300 enoyl-CoA hydratase activity 2/2274 12/18639 0.166666666666667 1.36609498680739 0.440258270621376 0.999999999999997 GO:0004526 ribonuclease P activity 2/2274 12/18639 0.166666666666667 1.36609498680739 0.440258270621376 0.999999999999997 GO:0005049 nuclear export signal receptor activity 2/2274 12/18639 0.166666666666667 1.36609498680739 0.440258270621376 0.999999999999997 GO:0008603 cAMP-dependent protein kinase regulator activity 2/2274 12/18639 0.166666666666667 1.36609498680739 0.440258270621376 0.999999999999997 GO:0016208 AMP binding 2/2274 12/18639 0.166666666666667 1.36609498680739 0.440258270621376 0.999999999999997 GO:0016801 hydrolase activity, acting on ether bonds 2/2274 12/18639 0.166666666666667 1.36609498680739 0.440258270621376 0.999999999999997 GO:0016803 ether hydrolase activity 2/2274 12/18639 0.166666666666667 1.36609498680739 0.440258270621376 0.999999999999997 GO:0035259 nuclear glucocorticoid receptor binding 2/2274 12/18639 0.166666666666667 1.36609498680739 0.440258270621376 0.999999999999997 GO:0043047 single-stranded telomeric DNA binding 2/2274 12/18639 0.166666666666667 1.36609498680739 0.440258270621376 0.999999999999997 GO:0010851 cyclase regulator activity 3/2274 20/18639 0.15 1.22948548812665 0.448108224431819 0.999999999999997 GO:0052745 inositol phosphate phosphatase activity 3/2274 20/18639 0.15 1.22948548812665 0.448108224431819 0.999999999999997 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 23/2274 181/18639 0.12707182320442 1.0415530838642 0.450939244622567 0.999999999999997 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 4/2274 28/18639 0.142857142857143 1.17093856012062 0.451018702279951 0.999999999999997 GO:0140030 modification-dependent protein binding 22/2274 173/18639 0.127167630057803 1.04233837143685 0.452029407685734 0.999999999999997 GO:0140097 catalytic activity, acting on DNA 42/2274 336/18639 0.125 1.02457124010554 0.457944829194782 0.999999999999997 GO:0019902 phosphatase binding 24/2274 190/18639 0.126315789473684 1.0353562005277 0.460715655273705 0.999999999999997 GO:0051213 dioxygenase activity 12/2274 93/18639 0.129032258064516 1.05762192527024 0.464659651537901 0.999999999999997 GO:0019842 vitamin binding 19/2274 150/18639 0.126666666666667 1.03823218997361 0.467668949944821 0.999999999999997 GO:0002039 p53 binding 9/2274 69/18639 0.130434782608696 1.0691178157623 0.469388838355361 0.999999999999997 GO:0001664 G protein-coupled receptor binding 37/2274 297/18639 0.124579124579125 1.02112150529037 0.472408957833678 0.999999999999997 GO:0051018 protein kinase A binding 7/2274 53/18639 0.132075471698113 1.08256583860208 0.472948197257544 0.999999999999997 GO:1901505 carbohydrate derivative transmembrane transporter activity 7/2274 53/18639 0.132075471698113 1.08256583860208 0.472948197257544 0.999999999999997 GO:0004629 phospholipase C activity 4/2274 29/18639 0.137931034482759 1.13056136839232 0.479105564449405 0.999999999999997 GO:0051861 glycolipid binding 4/2274 29/18639 0.137931034482759 1.13056136839232 0.479105564449405 0.999999999999997 GO:0005123 death receptor binding 3/2274 21/18639 0.142857142857143 1.17093856012062 0.481297541764458 0.999999999999997 GO:0070182 DNA polymerase binding 3/2274 21/18639 0.142857142857143 1.17093856012062 0.481297541764458 0.999999999999997 GO:0140312 cargo adaptor activity 3/2274 21/18639 0.142857142857143 1.17093856012062 0.481297541764458 0.999999999999997 GO:1904047 S-adenosyl-L-methionine binding 3/2274 21/18639 0.142857142857143 1.17093856012062 0.481297541764458 0.999999999999997 GO:0005172 vascular endothelial growth factor receptor binding 2/2274 13/18639 0.153846153846154 1.26101075705297 0.482966470623306 0.999999999999997 GO:0009982 pseudouridine synthase activity 2/2274 13/18639 0.153846153846154 1.26101075705297 0.482966470623306 0.999999999999997 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 2/2274 13/18639 0.153846153846154 1.26101075705297 0.482966470623306 0.999999999999997 GO:0017154 semaphorin receptor activity 2/2274 13/18639 0.153846153846154 1.26101075705297 0.482966470623306 0.999999999999997 GO:0035673 oligopeptide transmembrane transporter activity 2/2274 13/18639 0.153846153846154 1.26101075705297 0.482966470623306 0.999999999999997 GO:0039706 co-receptor binding 2/2274 13/18639 0.153846153846154 1.26101075705297 0.482966470623306 0.999999999999997 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 2/2274 13/18639 0.153846153846154 1.26101075705297 0.482966470623306 0.999999999999997 GO:0070700 BMP receptor binding 2/2274 13/18639 0.153846153846154 1.26101075705297 0.482966470623306 0.999999999999997 GO:0097157 pre-mRNA intronic binding 2/2274 13/18639 0.153846153846154 1.26101075705297 0.482966470623306 0.999999999999997 GO:0016247 channel regulator activity 21/2274 168/18639 0.125 1.02457124010554 0.487896600367829 0.999999999999997 GO:1902936 phosphatidylinositol bisphosphate binding 14/2274 111/18639 0.126126126126126 1.03380161163802 0.490308496254375 0.999999999999997 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 7/2274 54/18639 0.12962962962963 1.06251832307241 0.493381307330031 0.999999999999997 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 6/2274 46/18639 0.130434782608696 1.0691178157623 0.497039762999107 0.999999999999997 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 5/2274 38/18639 0.131578947368421 1.07849604221636 0.501340660184007 0.999999999999997 GO:0046332 SMAD binding 10/2274 79/18639 0.126582278481013 1.03754049630941 0.501567876731544 0.999999999999997 GO:0015215 nucleotide transmembrane transporter activity 4/2274 30/18639 0.133333333333333 1.09287598944591 0.506611951643259 0.999999999999997 GO:0031210 phosphatidylcholine binding 4/2274 30/18639 0.133333333333333 1.09287598944591 0.506611951643259 0.999999999999997 GO:0033612 receptor serine/threonine kinase binding 4/2274 30/18639 0.133333333333333 1.09287598944591 0.506611951643259 0.999999999999997 GO:0048019 receptor antagonist activity 4/2274 30/18639 0.133333333333333 1.09287598944591 0.506611951643259 0.999999999999997 GO:0051721 protein phosphatase 2A binding 4/2274 30/18639 0.133333333333333 1.09287598944591 0.506611951643259 0.999999999999997 GO:0141108 transporter regulator activity 21/2274 170/18639 0.123529411764706 1.01251746081018 0.51088879866864 0.999999999999997 GO:0008083 growth factor activity 20/2274 162/18639 0.123456790123457 1.01192221244992 0.513448686174777 0.999999999999997 GO:0070034 telomerase RNA binding 3/2274 22/18639 0.136363636363636 1.11771408011514 0.513505934262861 0.999999999999997 GO:0140035 ubiquitin-like protein reader activity 3/2274 22/18639 0.136363636363636 1.11771408011514 0.513505934262861 0.999999999999997 GO:0043495 protein-membrane adaptor activity 6/2274 47/18639 0.127659574468085 1.04637062819289 0.518864976661225 0.999999999999997 GO:0004065 arylsulfatase activity 2/2274 14/18639 0.142857142857143 1.17093856012062 0.523590010911123 0.999999999999997 GO:0005313 L-glutamate transmembrane transporter activity 2/2274 14/18639 0.142857142857143 1.17093856012062 0.523590010911123 0.999999999999997 GO:0005545 1-phosphatidylinositol binding 2/2274 14/18639 0.142857142857143 1.17093856012062 0.523590010911123 0.999999999999997 GO:0008174 mRNA methyltransferase activity 2/2274 14/18639 0.142857142857143 1.17093856012062 0.523590010911123 0.999999999999997 GO:0008559 ABC-type xenobiotic transporter activity 2/2274 14/18639 0.142857142857143 1.17093856012062 0.523590010911123 0.999999999999997 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 2/2274 14/18639 0.142857142857143 1.17093856012062 0.523590010911123 0.999999999999997 GO:0019992 diacylglycerol binding 2/2274 14/18639 0.142857142857143 1.17093856012062 0.523590010911123 0.999999999999997 GO:0030983 mismatched DNA binding 2/2274 14/18639 0.142857142857143 1.17093856012062 0.523590010911123 0.999999999999997 GO:0034236 protein kinase A catalytic subunit binding 2/2274 14/18639 0.142857142857143 1.17093856012062 0.523590010911123 0.999999999999997 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 2/2274 14/18639 0.142857142857143 1.17093856012062 0.523590010911123 0.999999999999997 GO:0042043 neurexin family protein binding 2/2274 14/18639 0.142857142857143 1.17093856012062 0.523590010911123 0.999999999999997 GO:0042813 Wnt receptor activity 2/2274 14/18639 0.142857142857143 1.17093856012062 0.523590010911123 0.999999999999997 GO:0044548 S100 protein binding 2/2274 14/18639 0.142857142857143 1.17093856012062 0.523590010911123 0.999999999999997 GO:0046030 inositol trisphosphate phosphatase activity 2/2274 14/18639 0.142857142857143 1.17093856012062 0.523590010911123 0.999999999999997 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 2/2274 14/18639 0.142857142857143 1.17093856012062 0.523590010911123 0.999999999999997 GO:0098847 sequence-specific single stranded DNA binding 2/2274 14/18639 0.142857142857143 1.17093856012062 0.523590010911123 0.999999999999997 GO:0017147 Wnt-protein binding 4/2274 31/18639 0.129032258064516 1.05762192527024 0.533446449906367 0.999999999999997 GO:0072349 modified amino acid transmembrane transporter activity 4/2274 31/18639 0.129032258064516 1.05762192527024 0.533446449906367 0.999999999999997 GO:0030971 receptor tyrosine kinase binding 10/2274 81/18639 0.123456790123457 1.01192221244992 0.534782989615515 0.999999999999997 GO:0140713 histone chaperone activity 20/2274 164/18639 0.121951219512195 0.999581697663942 0.536744103018447 0.999999999999997 GO:0008170 N-methyltransferase activity 12/2274 98/18639 0.122448979591837 1.00366162296053 0.540859878875719 0.999999999999997 GO:0004022 alcohol dehydrogenase (NAD+) activity 3/2274 23/18639 0.130434782608696 1.0691178157623 0.544613321175724 0.999999999999997 GO:0042171 lysophosphatidic acid acyltransferase activity 3/2274 23/18639 0.130434782608696 1.0691178157623 0.544613321175724 0.999999999999997 GO:0071617 lysophospholipid acyltransferase activity 3/2274 23/18639 0.130434782608696 1.0691178157623 0.544613321175724 0.999999999999997 GO:0120013 lipid transfer activity 8/2274 65/18639 0.123076923076923 1.00880860564238 0.546042868411204 0.999999999999997 GO:0001221 transcription coregulator binding 14/2274 115/18639 0.121739130434783 0.997843294711483 0.546235117867692 0.999999999999997 GO:0017124 SH3 domain binding 14/2274 115/18639 0.121739130434783 0.997843294711483 0.546235117867692 0.999999999999997 GO:0004532 RNA exonuclease activity 5/2274 40/18639 0.125 1.02457124010554 0.548713789080868 0.999999999999997 GO:0015144 carbohydrate transmembrane transporter activity 5/2274 40/18639 0.125 1.02457124010554 0.548713789080868 0.999999999999997 GO:0030331 nuclear estrogen receptor binding 5/2274 40/18639 0.125 1.02457124010554 0.548713789080868 0.999999999999997 GO:0032451 demethylase activity 5/2274 40/18639 0.125 1.02457124010554 0.548713789080868 0.999999999999997 GO:0061791 GTPase motor activity 5/2274 40/18639 0.125 1.02457124010554 0.548713789080868 0.999999999999997 GO:0071855 neuropeptide receptor binding 5/2274 40/18639 0.125 1.02457124010554 0.548713789080868 0.999999999999997 GO:1990606 membrane scission GTPase motor activity 5/2274 40/18639 0.125 1.02457124010554 0.548713789080868 0.999999999999997 GO:0042910 xenobiotic transmembrane transporter activity 4/2274 32/18639 0.125 1.02457124010554 0.559531779970438 0.999999999999997 GO:0140142 nucleocytoplasmic carrier activity 4/2274 32/18639 0.125 1.02457124010554 0.559531779970438 0.999999999999997 GO:0035254 glutamate receptor binding 6/2274 49/18639 0.122448979591837 1.00366162296053 0.561326393726437 0.999999999999997 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 2/2274 15/18639 0.133333333333333 1.09287598944591 0.562001717924332 0.999999999999997 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 2/2274 15/18639 0.133333333333333 1.09287598944591 0.562001717924332 0.999999999999997 GO:0005402 carbohydrate:monoatomic cation symporter activity 2/2274 15/18639 0.133333333333333 1.09287598944591 0.562001717924332 0.999999999999997 GO:0005523 tropomyosin binding 2/2274 15/18639 0.133333333333333 1.09287598944591 0.562001717924332 0.999999999999997 GO:0008242 omega peptidase activity 2/2274 15/18639 0.133333333333333 1.09287598944591 0.562001717924332 0.999999999999997 GO:0015116 sulfate transmembrane transporter activity 2/2274 15/18639 0.133333333333333 1.09287598944591 0.562001717924332 0.999999999999997 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 2/2274 15/18639 0.133333333333333 1.09287598944591 0.562001717924332 0.999999999999997 GO:0034483 heparan sulfate sulfotransferase activity 2/2274 15/18639 0.133333333333333 1.09287598944591 0.562001717924332 0.999999999999997 GO:0048531 beta-1,3-galactosyltransferase activity 2/2274 15/18639 0.133333333333333 1.09287598944591 0.562001717924332 0.999999999999997 GO:0050700 CARD domain binding 2/2274 15/18639 0.133333333333333 1.09287598944591 0.562001717924332 0.999999999999997 GO:0061578 K63-linked deubiquitinase activity 2/2274 15/18639 0.133333333333333 1.09287598944591 0.562001717924332 0.999999999999997 GO:0140161 monocarboxylate:sodium symporter activity 2/2274 15/18639 0.133333333333333 1.09287598944591 0.562001717924332 0.999999999999997 GO:0141050 histone H3K deacetylase activity 2/2274 15/18639 0.133333333333333 1.09287598944591 0.562001717924332 0.999999999999997 GO:0141051 histone H4K deacetylase activity 2/2274 15/18639 0.133333333333333 1.09287598944591 0.562001717924332 0.999999999999997 GO:0001540 amyloid-beta binding 10/2274 83/18639 0.120481927710843 0.987538544680039 0.567190584118869 0.999999999999997 GO:0030165 PDZ domain binding 10/2274 83/18639 0.120481927710843 0.987538544680039 0.567190584118869 0.999999999999997 GO:0016757 glycosyltransferase activity 32/2274 267/18639 0.119850187265918 0.98236043995138 0.57143359833498 0.999999999999997 GO:1990782 protein tyrosine kinase binding 14/2274 117/18639 0.11965811965812 0.980786144374535 0.573421001944502 0.999999999999997 GO:0004622 lysophospholipase activity 3/2274 24/18639 0.125 1.02457124010554 0.574527055134958 0.999999999999997 GO:0005540 hyaluronic acid binding 3/2274 24/18639 0.125 1.02457124010554 0.574527055134958 0.999999999999997 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 3/2274 24/18639 0.125 1.02457124010554 0.574527055134958 0.999999999999997 GO:0030552 cAMP binding 3/2274 24/18639 0.125 1.02457124010554 0.574527055134958 0.999999999999997 GO:0000510 H3-H4 histone complex chaperone activity 18/2274 151/18639 0.119205298013245 0.977074560100648 0.579418553513308 0.999999999999997 GO:0140584 chromatin extrusion motor activity 18/2274 151/18639 0.119205298013245 0.977074560100648 0.579418553513308 0.999999999999997 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 18/2274 151/18639 0.119205298013245 0.977074560100648 0.579418553513308 0.999999999999997 GO:0140849 ATP-dependent H2AZ histone chaperone activity 18/2274 151/18639 0.119205298013245 0.977074560100648 0.579418553513308 0.999999999999997 GO:0140311 protein sequestering activity 4/2274 33/18639 0.121212121212121 0.993523626769009 0.584804050866292 0.999999999999997 GO:0140416 transcription regulator inhibitor activity 4/2274 33/18639 0.121212121212121 0.993523626769009 0.584804050866292 0.999999999999997 GO:0015616 DNA translocase activity 18/2274 152/18639 0.118421052631579 0.970646437994723 0.591160618483561 0.999999999999997 GO:0140674 ATP-dependent histone chaperone activity 18/2274 152/18639 0.118421052631579 0.970646437994723 0.591160618483561 0.999999999999997 GO:0042056 chemoattractant activity 5/2274 42/18639 0.119047619047619 0.975782133433848 0.593804493379296 0.999999999999997 GO:0003688 DNA replication origin binding 2/2274 16/18639 0.125 1.02457124010554 0.598136442305315 0.999999999999997 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 2/2274 16/18639 0.125 1.02457124010554 0.598136442305315 0.999999999999997 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 2/2274 16/18639 0.125 1.02457124010554 0.598136442305315 0.999999999999997 GO:0019841 retinol binding 2/2274 16/18639 0.125 1.02457124010554 0.598136442305315 0.999999999999997 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity 2/2274 16/18639 0.125 1.02457124010554 0.598136442305315 0.999999999999997 GO:0034450 ubiquitin-ubiquitin ligase activity 2/2274 16/18639 0.125 1.02457124010554 0.598136442305315 0.999999999999997 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 2/2274 16/18639 0.125 1.02457124010554 0.598136442305315 0.999999999999997 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 2/2274 16/18639 0.125 1.02457124010554 0.598136442305315 0.999999999999997 GO:0070411 I-SMAD binding 2/2274 16/18639 0.125 1.02457124010554 0.598136442305315 0.999999999999997 GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 2/2274 16/18639 0.125 1.02457124010554 0.598136442305315 0.999999999999997 GO:0005548 phospholipid transporter activity 8/2274 68/18639 0.117647058823529 0.964302343628744 0.599272502133143 0.999999999999997 GO:0019207 kinase regulator activity 34/2274 287/18639 0.118466898954704 0.97102222058783 0.600448308120013 0.999999999999997 GO:0002020 protease binding 16/2274 136/18639 0.117647058823529 0.964302343628744 0.601246661910924 0.999999999999997 GO:0061775 cohesin loader activity 18/2274 153/18639 0.117647058823529 0.964302343628744 0.602767969952918 0.999999999999997 GO:0015645 fatty acid ligase activity 3/2274 25/18639 0.12 0.983588390501319 0.603179025998908 0.999999999999997 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 3/2274 25/18639 0.12 0.983588390501319 0.603179025998908 0.999999999999997 GO:0120515 fatty acid-CoA ligase activity 3/2274 25/18639 0.12 0.983588390501319 0.603179025998908 0.999999999999997 GO:0031406 carboxylic acid binding 22/2274 187/18639 0.117647058823529 0.964302343628744 0.606180153476611 0.999999999999997 GO:0042578 phosphoric ester hydrolase activity 43/2274 363/18639 0.118457300275482 0.970943544342441 0.606878509205494 0.999999999999997 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 7/2274 60/18639 0.116666666666667 0.956266490765172 0.609379344620058 0.999999999999997 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 7/2274 60/18639 0.116666666666667 0.956266490765172 0.609379344620058 0.999999999999997 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 10/2274 86/18639 0.116279069767442 0.953089525679573 0.613921045196584 0.999999999999997 GO:0050660 flavin adenine dinucleotide binding 10/2274 86/18639 0.116279069767442 0.953089525679573 0.613921045196584 0.999999999999997 GO:0004867 serine-type endopeptidase inhibitor activity 11/2274 95/18639 0.115789473684211 0.949076517150396 0.620528939288631 0.999999999999997 GO:0043177 organic acid binding 22/2274 189/18639 0.116402116402116 0.954098086024207 0.626799210753065 0.999999999999997 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 41/2274 349/18639 0.117478510028653 0.962920821646468 0.627526456503462 0.999999999999997 GO:0005160 transforming growth factor beta receptor binding 3/2274 26/18639 0.115384615384615 0.94575806778973 0.63052281817903 0.999999999999997 GO:0008066 glutamate receptor activity 3/2274 26/18639 0.115384615384615 0.94575806778973 0.63052281817903 0.999999999999997 GO:0008143 poly(A) binding 3/2274 26/18639 0.115384615384615 0.94575806778973 0.63052281817903 0.999999999999997 GO:0050681 nuclear androgen receptor binding 3/2274 26/18639 0.115384615384615 0.94575806778973 0.63052281817903 0.999999999999997 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 15/2274 130/18639 0.115384615384615 0.94575806778973 0.631586656620216 0.999999999999997 GO:0008484 sulfuric ester hydrolase activity 2/2274 17/18639 0.117647058823529 0.964302343628744 0.631977828597016 0.999999999999997 GO:0016018 cyclosporin A binding 2/2274 17/18639 0.117647058823529 0.964302343628744 0.631977828597016 0.999999999999997 GO:0016805 dipeptidase activity 2/2274 17/18639 0.117647058823529 0.964302343628744 0.631977828597016 0.999999999999997 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 2/2274 17/18639 0.117647058823529 0.964302343628744 0.631977828597016 0.999999999999997 GO:0031489 myosin V binding 2/2274 17/18639 0.117647058823529 0.964302343628744 0.631977828597016 0.999999999999997 GO:0032183 SUMO binding 2/2274 17/18639 0.117647058823529 0.964302343628744 0.631977828597016 0.999999999999997 GO:0038191 neuropilin binding 2/2274 17/18639 0.117647058823529 0.964302343628744 0.631977828597016 0.999999999999997 GO:0045125 bioactive lipid receptor activity 2/2274 17/18639 0.117647058823529 0.964302343628744 0.631977828597016 0.999999999999997 GO:0046965 nuclear retinoid X receptor binding 2/2274 17/18639 0.117647058823529 0.964302343628744 0.631977828597016 0.999999999999997 GO:0070402 NADPH binding 2/2274 17/18639 0.117647058823529 0.964302343628744 0.631977828597016 0.999999999999997 GO:0070403 NAD+ binding 2/2274 17/18639 0.117647058823529 0.964302343628744 0.631977828597016 0.999999999999997 GO:0061631 ubiquitin conjugating enzyme activity 4/2274 35/18639 0.114285714285714 0.936750848096494 0.632715614663953 0.999999999999997 GO:0016251 RNA polymerase II general transcription initiation factor activity 6/2274 53/18639 0.113207547169811 0.927913575944641 0.640395191881547 0.999999999999997 GO:0046982 protein heterodimerization activity 43/2274 369/18639 0.116531165311653 0.955155844434434 0.651055427022115 0.999999999999997 GO:0004190 aspartic-type endopeptidase activity 4/2274 36/18639 0.111111111111111 0.910729991204925 0.65528608636725 0.999999999999997 GO:0005484 SNAP receptor activity 4/2274 36/18639 0.111111111111111 0.910729991204925 0.65528608636725 0.999999999999997 GO:0005044 scavenger receptor activity 3/2274 27/18639 0.111111111111111 0.910729991204925 0.656530981261724 0.999999999999997 GO:0016405 CoA-ligase activity 3/2274 27/18639 0.111111111111111 0.910729991204925 0.656530981261724 0.999999999999997 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 3/2274 27/18639 0.111111111111111 0.910729991204925 0.656530981261724 0.999999999999997 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 3/2274 27/18639 0.111111111111111 0.910729991204925 0.656530981261724 0.999999999999997 GO:0140658 ATP-dependent chromatin remodeler activity 18/2274 158/18639 0.113924050632911 0.933786446678468 0.658521095185963 0.999999999999997 GO:0050661 NADP binding 6/2274 54/18639 0.111111111111111 0.910729991204925 0.658771927450486 0.999999999999997 GO:1901682 sulfur compound transmembrane transporter activity 7/2274 63/18639 0.111111111111111 0.910729991204925 0.661717777608301 0.999999999999997 GO:0042626 ATPase-coupled transmembrane transporter activity 11/2274 98/18639 0.112244897959184 0.920023154380486 0.66229102581173 0.999999999999997 GO:0008308 voltage-gated monoatomic anion channel activity 2/2274 18/18639 0.111111111111111 0.910729991204925 0.663547387854139 0.999999999999997 GO:0008409 5'-3' exonuclease activity 2/2274 18/18639 0.111111111111111 0.910729991204925 0.663547387854139 0.999999999999997 GO:0008525 phosphatidylcholine transporter activity 2/2274 18/18639 0.111111111111111 0.910729991204925 0.663547387854139 0.999999999999997 GO:0015172 acidic amino acid transmembrane transporter activity 2/2274 18/18639 0.111111111111111 0.910729991204925 0.663547387854139 0.999999999999997 GO:0030228 lipoprotein particle receptor activity 2/2274 18/18639 0.111111111111111 0.910729991204925 0.663547387854139 0.999999999999997 GO:0070064 proline-rich region binding 2/2274 18/18639 0.111111111111111 0.910729991204925 0.663547387854139 0.999999999999997 GO:1990381 ubiquitin-specific protease binding 2/2274 18/18639 0.111111111111111 0.910729991204925 0.663547387854139 0.999999999999997 GO:0001618 virus receptor activity 9/2274 81/18639 0.111111111111111 0.910729991204925 0.668466304984594 0.999999999999997 GO:0030551 cyclic nucleotide binding 4/2274 37/18639 0.108108108108108 0.886115667118306 0.676903920108432 0.999999999999997 GO:0043394 proteoglycan binding 4/2274 37/18639 0.108108108108108 0.886115667118306 0.676903920108432 0.999999999999997 GO:0070001 aspartic-type peptidase activity 4/2274 37/18639 0.108108108108108 0.886115667118306 0.676903920108432 0.999999999999997 GO:0005496 steroid binding 12/2274 108/18639 0.111111111111111 0.910729991204925 0.679212917011583 0.999999999999997 GO:0099106 ion channel regulator activity 18/2274 160/18639 0.1125 0.922114116094987 0.67963606802273 0.999999999999997 GO:0043539 protein serine/threonine kinase activator activity 8/2274 73/18639 0.10958904109589 0.898254237900748 0.680380158655835 0.999999999999997 GO:0019789 SUMO transferase activity 3/2274 28/18639 0.107142857142857 0.878203920090464 0.681192454739537 0.999999999999997 GO:0051119 sugar transmembrane transporter activity 3/2274 28/18639 0.107142857142857 0.878203920090464 0.681192454739537 0.999999999999997 GO:0051959 dynein light intermediate chain binding 3/2274 28/18639 0.107142857142857 0.878203920090464 0.681192454739537 0.999999999999997 GO:0140272 exogenous protein binding 9/2274 82/18639 0.109756097560976 0.899623527897548 0.682936245442112 0.999999999999997 GO:0043130 ubiquitin binding 11/2274 100/18639 0.11 0.901622691292876 0.688631487505579 0.999999999999997 GO:0004620 phospholipase activity 12/2274 109/18639 0.110091743119266 0.902374670184697 0.691631050551958 0.999999999999997 GO:0008301 DNA binding, bending 2/2274 19/18639 0.105263157894737 0.862796833773087 0.692895508531631 0.999999999999997 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 2/2274 19/18639 0.105263157894737 0.862796833773087 0.692895508531631 0.999999999999997 GO:0016918 retinal binding 2/2274 19/18639 0.105263157894737 0.862796833773087 0.692895508531631 0.999999999999997 GO:0043395 heparan sulfate proteoglycan binding 2/2274 19/18639 0.105263157894737 0.862796833773087 0.692895508531631 0.999999999999997 GO:0046527 glucosyltransferase activity 2/2274 19/18639 0.105263157894737 0.862796833773087 0.692895508531631 0.999999999999997 GO:0046624 sphingolipid transporter activity 2/2274 19/18639 0.105263157894737 0.862796833773087 0.692895508531631 0.999999999999997 GO:0070003 threonine-type peptidase activity 2/2274 19/18639 0.105263157894737 0.862796833773087 0.692895508531631 0.999999999999997 GO:0140036 ubiquitin-modified protein reader activity 2/2274 19/18639 0.105263157894737 0.862796833773087 0.692895508531631 0.999999999999997 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 6/2274 56/18639 0.107142857142857 0.878203920090464 0.693724028795034 0.999999999999997 GO:0031491 nucleosome binding 8/2274 74/18639 0.108108108108108 0.886115667118306 0.695314456845954 0.999999999999997 GO:0035064 methylated histone binding 8/2274 74/18639 0.108108108108108 0.886115667118306 0.695314456845954 0.999999999999997 GO:0042162 telomeric DNA binding 4/2274 38/18639 0.105263157894737 0.862796833773087 0.697558421276012 0.999999999999997 GO:0043178 alcohol binding 10/2274 92/18639 0.108695652173913 0.890931513135253 0.699054112448235 0.999999999999997 GO:0052689 carboxylic ester hydrolase activity 10/2274 92/18639 0.108695652173913 0.890931513135253 0.699054112448235 0.999999999999997 GO:0016779 nucleotidyltransferase activity 15/2274 136/18639 0.110294117647059 0.904033447151948 0.700807507185347 0.999999999999997 GO:0003785 actin monomer binding 3/2274 29/18639 0.103448275862069 0.847921026294241 0.704510172849937 0.999999999999997 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 14/2274 128/18639 0.109375 0.896499835092348 0.708901888972385 0.999999999999997 GO:0003725 double-stranded RNA binding 8/2274 75/18639 0.106666666666667 0.874300791556728 0.70979576321917 0.999999999999997 GO:0015932 nucleobase-containing compound transmembrane transporter activity 6/2274 57/18639 0.105263157894737 0.862796833773087 0.710277919411136 0.999999999999997 GO:0004527 exonuclease activity 9/2274 84/18639 0.107142857142857 0.878203920090464 0.710690573908064 0.999999999999997 GO:0032266 phosphatidylinositol-3-phosphate binding 5/2274 48/18639 0.104166666666667 0.853809366754617 0.712514085339098 0.999999999999997 GO:0032182 ubiquitin-like protein binding 13/2274 120/18639 0.108333333333333 0.887961741424802 0.717637709173641 0.999999999999997 GO:0001614 purinergic nucleotide receptor activity 2/2274 20/18639 0.1 0.819656992084433 0.720094095653832 0.999999999999997 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 2/2274 20/18639 0.1 0.819656992084433 0.720094095653832 0.999999999999997 GO:0015464 acetylcholine receptor activity 2/2274 20/18639 0.1 0.819656992084433 0.720094095653832 0.999999999999997 GO:0016004 phospholipase activator activity 2/2274 20/18639 0.1 0.819656992084433 0.720094095653832 0.999999999999997 GO:0016408 C-acyltransferase activity 2/2274 20/18639 0.1 0.819656992084433 0.720094095653832 0.999999999999997 GO:0016502 nucleotide receptor activity 2/2274 20/18639 0.1 0.819656992084433 0.720094095653832 0.999999999999997 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 2/2274 20/18639 0.1 0.819656992084433 0.720094095653832 0.999999999999997 GO:0061608 nuclear import signal receptor activity 2/2274 20/18639 0.1 0.819656992084433 0.720094095653832 0.999999999999997 GO:0098631 cell adhesion mediator activity 8/2274 76/18639 0.105263157894737 0.862796833773087 0.723818179189754 0.999999999999997 GO:0140034 methylation-dependent protein binding 8/2274 76/18639 0.105263157894737 0.862796833773087 0.723818179189754 0.999999999999997 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 1/2274 10/18639 0.1 0.819656992084433 0.727862579588564 0.999999999999997 GO:0003680 minor groove of adenine-thymine-rich DNA binding 1/2274 10/18639 0.1 0.819656992084433 0.727862579588564 0.999999999999997 GO:0004382 GDP phosphatase activity 1/2274 10/18639 0.1 0.819656992084433 0.727862579588564 0.999999999999997 GO:0004445 inositol-polyphosphate 5-phosphatase activity 1/2274 10/18639 0.1 0.819656992084433 0.727862579588564 0.999999999999997 GO:0004955 prostaglandin receptor activity 1/2274 10/18639 0.1 0.819656992084433 0.727862579588564 0.999999999999997 GO:0004983 neuropeptide Y receptor activity 1/2274 10/18639 0.1 0.819656992084433 0.727862579588564 0.999999999999997 GO:0005131 growth hormone receptor binding 1/2274 10/18639 0.1 0.819656992084433 0.727862579588564 0.999999999999997 GO:0005337 nucleoside transmembrane transporter activity 1/2274 10/18639 0.1 0.819656992084433 0.727862579588564 0.999999999999997 GO:0008239 dipeptidyl-peptidase activity 1/2274 10/18639 0.1 0.819656992084433 0.727862579588564 0.999999999999997 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 1/2274 10/18639 0.1 0.819656992084433 0.727862579588564 0.999999999999997 GO:0008519 ammonium channel activity 1/2274 10/18639 0.1 0.819656992084433 0.727862579588564 0.999999999999997 GO:0008641 ubiquitin-like modifier activating enzyme activity 1/2274 10/18639 0.1 0.819656992084433 0.727862579588564 0.999999999999997 GO:0015187 glycine transmembrane transporter activity 1/2274 10/18639 0.1 0.819656992084433 0.727862579588564 0.999999999999997 GO:0015279 store-operated calcium channel activity 1/2274 10/18639 0.1 0.819656992084433 0.727862579588564 0.999999999999997 GO:0015658 branched-chain amino acid transmembrane transporter activity 1/2274 10/18639 0.1 0.819656992084433 0.727862579588564 0.999999999999997 GO:0016175 superoxide-generating NAD(P)H oxidase activity 1/2274 10/18639 0.1 0.819656992084433 0.727862579588564 0.999999999999997 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 1/2274 10/18639 0.1 0.819656992084433 0.727862579588564 0.999999999999997 GO:0019531 oxalate transmembrane transporter activity 1/2274 10/18639 0.1 0.819656992084433 0.727862579588564 0.999999999999997 GO:0019911 structural constituent of myelin sheath 1/2274 10/18639 0.1 0.819656992084433 0.727862579588564 0.999999999999997 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 1/2274 10/18639 0.1 0.819656992084433 0.727862579588564 0.999999999999997 GO:0031956 medium-chain fatty acid-CoA ligase activity 1/2274 10/18639 0.1 0.819656992084433 0.727862579588564 0.999999999999997 GO:0032356 oxidized DNA binding 1/2274 10/18639 0.1 0.819656992084433 0.727862579588564 0.999999999999997 GO:0032395 MHC class II receptor activity 1/2274 10/18639 0.1 0.819656992084433 0.727862579588564 0.999999999999997 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 1/2274 10/18639 0.1 0.819656992084433 0.727862579588564 0.999999999999997 GO:0035256 G protein-coupled glutamate receptor binding 1/2274 10/18639 0.1 0.819656992084433 0.727862579588564 0.999999999999997 GO:0042166 acetylcholine binding 1/2274 10/18639 0.1 0.819656992084433 0.727862579588564 0.999999999999997 GO:0042975 peroxisome proliferator activated receptor binding 1/2274 10/18639 0.1 0.819656992084433 0.727862579588564 0.999999999999997 GO:0050308 sugar-phosphatase activity 1/2274 10/18639 0.1 0.819656992084433 0.727862579588564 0.999999999999997 GO:0051880 G-quadruplex DNA binding 1/2274 10/18639 0.1 0.819656992084433 0.727862579588564 0.999999999999997 GO:0099122 RNA polymerase II C-terminal domain binding 1/2274 10/18639 0.1 0.819656992084433 0.727862579588564 0.999999999999997 GO:0140135 mechanosensitive monoatomic cation channel activity 1/2274 10/18639 0.1 0.819656992084433 0.727862579588564 0.999999999999997 GO:0141109 transporter activator activity 1/2274 10/18639 0.1 0.819656992084433 0.727862579588564 0.999999999999997 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 1/2274 10/18639 0.1 0.819656992084433 0.727862579588564 0.999999999999997 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 1/2274 10/18639 0.1 0.819656992084433 0.727862579588564 0.999999999999997 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 1/2274 10/18639 0.1 0.819656992084433 0.727862579588564 0.999999999999997 GO:1990757 ubiquitin ligase activator activity 1/2274 10/18639 0.1 0.819656992084433 0.727862579588564 0.999999999999997 GO:0016298 lipase activity 14/2274 130/18639 0.107692307692308 0.882707529937081 0.730455247149918 0.999999999999997 GO:0016798 hydrolase activity, acting on glycosyl bonds 14/2274 130/18639 0.107692307692308 0.882707529937081 0.730455247149918 0.999999999999997 GO:0004177 aminopeptidase activity 4/2274 40/18639 0.1 0.819656992084433 0.735972528620796 0.999999999999997 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 4/2274 40/18639 0.1 0.819656992084433 0.735972528620796 0.999999999999997 GO:0071949 FAD binding 4/2274 40/18639 0.1 0.819656992084433 0.735972528620796 0.999999999999997 GO:0008276 protein methyltransferase activity 10/2274 95/18639 0.105263157894737 0.862796833773087 0.736902116209234 0.999999999999997 GO:0030145 manganese ion binding 7/2274 68/18639 0.102941176470588 0.843764550675151 0.738812416659725 0.999999999999997 GO:1990841 promoter-specific chromatin binding 7/2274 68/18639 0.102941176470588 0.843764550675151 0.738812416659725 0.999999999999997 GO:0070888 E-box binding 6/2274 59/18639 0.101694915254237 0.833549483475694 0.741514608584284 0.999999999999997 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 2/2274 21/18639 0.0952380952380952 0.780625706747079 0.745230575010609 0.999999999999997 GO:0009931 calcium-dependent protein serine/threonine kinase activity 2/2274 21/18639 0.0952380952380952 0.780625706747079 0.745230575010609 0.999999999999997 GO:0010314 phosphatidylinositol-5-phosphate binding 2/2274 21/18639 0.0952380952380952 0.780625706747079 0.745230575010609 0.999999999999997 GO:0019200 carbohydrate kinase activity 2/2274 21/18639 0.0952380952380952 0.780625706747079 0.745230575010609 0.999999999999997 GO:0035613 RNA stem-loop binding 2/2274 21/18639 0.0952380952380952 0.780625706747079 0.745230575010609 0.999999999999997 GO:0036122 BMP binding 2/2274 21/18639 0.0952380952380952 0.780625706747079 0.745230575010609 0.999999999999997 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 2/2274 21/18639 0.0952380952380952 0.780625706747079 0.745230575010609 0.999999999999997 GO:0051428 peptide hormone receptor binding 2/2274 21/18639 0.0952380952380952 0.780625706747079 0.745230575010609 0.999999999999997 GO:0005006 epidermal growth factor receptor activity 5/2274 50/18639 0.1 0.819656992084433 0.746118723007372 0.999999999999997 GO:0015605 organophosphate ester transmembrane transporter activity 5/2274 50/18639 0.1 0.819656992084433 0.746118723007372 0.999999999999997 GO:0032813 tumor necrosis factor receptor superfamily binding 5/2274 50/18639 0.1 0.819656992084433 0.746118723007372 0.999999999999997 GO:0005184 neuropeptide hormone activity 3/2274 31/18639 0.0967741935483871 0.793216443952677 0.747183051329633 0.999999999999997 GO:0047499 calcium-independent phospholipase A2 activity 3/2274 31/18639 0.0967741935483871 0.793216443952677 0.747183051329633 0.999999999999997 GO:0070273 phosphatidylinositol-4-phosphate binding 3/2274 31/18639 0.0967741935483871 0.793216443952677 0.747183051329633 0.999999999999997 GO:0016407 acetyltransferase activity 10/2274 96/18639 0.104166666666667 0.853809366754617 0.74878181477824 0.999999999999997 GO:1901981 phosphatidylinositol phosphate binding 20/2274 185/18639 0.108108108108108 0.886115667118306 0.751258011969782 0.999999999999997 GO:0008080 N-acetyltransferase activity 7/2274 69/18639 0.101449275362319 0.831536078926236 0.752643738270327 0.999999999999997 GO:0001530 lipopolysaccharide binding 4/2274 41/18639 0.0975609756097561 0.799665358131154 0.753745922179866 0.999999999999997 GO:0015175 neutral L-amino acid transmembrane transporter activity 4/2274 41/18639 0.0975609756097561 0.799665358131154 0.753745922179866 0.999999999999997 GO:0017080 sodium channel regulator activity 4/2274 41/18639 0.0975609756097561 0.799665358131154 0.753745922179866 0.999999999999997 GO:0042169 SH2 domain binding 4/2274 41/18639 0.0975609756097561 0.799665358131154 0.753745922179866 0.999999999999997 GO:0004714 transmembrane receptor protein tyrosine kinase activity 6/2274 60/18639 0.1 0.819656992084433 0.75619630458031 0.999999999999997 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 1/2274 11/18639 0.0909090909090909 0.745142720076757 0.761081780512694 0.999999999999997 GO:0004143 ATP-dependent diacylglycerol kinase activity 1/2274 11/18639 0.0909090909090909 0.745142720076757 0.761081780512694 0.999999999999997 GO:0004954 prostanoid receptor activity 1/2274 11/18639 0.0909090909090909 0.745142720076757 0.761081780512694 0.999999999999997 GO:0005225 volume-sensitive anion channel activity 1/2274 11/18639 0.0909090909090909 0.745142720076757 0.761081780512694 0.999999999999997 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 1/2274 11/18639 0.0909090909090909 0.745142720076757 0.761081780512694 0.999999999999997 GO:0016594 glycine binding 1/2274 11/18639 0.0909090909090909 0.745142720076757 0.761081780512694 0.999999999999997 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 1/2274 11/18639 0.0909090909090909 0.745142720076757 0.761081780512694 0.999999999999997 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 1/2274 11/18639 0.0909090909090909 0.745142720076757 0.761081780512694 0.999999999999997 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 1/2274 11/18639 0.0909090909090909 0.745142720076757 0.761081780512694 0.999999999999997 GO:0019203 carbohydrate phosphatase activity 1/2274 11/18639 0.0909090909090909 0.745142720076757 0.761081780512694 0.999999999999997 GO:0019206 nucleoside kinase activity 1/2274 11/18639 0.0909090909090909 0.745142720076757 0.761081780512694 0.999999999999997 GO:0019864 IgG binding 1/2274 11/18639 0.0909090909090909 0.745142720076757 0.761081780512694 0.999999999999997 GO:0031731 CCR6 chemokine receptor binding 1/2274 11/18639 0.0909090909090909 0.745142720076757 0.761081780512694 0.999999999999997 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 1/2274 11/18639 0.0909090909090909 0.745142720076757 0.761081780512694 0.999999999999997 GO:0034056 estrogen response element binding 1/2274 11/18639 0.0909090909090909 0.745142720076757 0.761081780512694 0.999999999999997 GO:0034713 type I transforming growth factor beta receptor binding 1/2274 11/18639 0.0909090909090909 0.745142720076757 0.761081780512694 0.999999999999997 GO:0035252 UDP-xylosyltransferase activity 1/2274 11/18639 0.0909090909090909 0.745142720076757 0.761081780512694 0.999999999999997 GO:0042285 xylosyltransferase activity 1/2274 11/18639 0.0909090909090909 0.745142720076757 0.761081780512694 0.999999999999997 GO:0050786 RAGE receptor binding 1/2274 11/18639 0.0909090909090909 0.745142720076757 0.761081780512694 0.999999999999997 GO:0050998 nitric-oxide synthase binding 1/2274 11/18639 0.0909090909090909 0.745142720076757 0.761081780512694 0.999999999999997 GO:0099528 G protein-coupled neurotransmitter receptor activity 1/2274 11/18639 0.0909090909090909 0.745142720076757 0.761081780512694 0.999999999999997 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 1/2274 11/18639 0.0909090909090909 0.745142720076757 0.761081780512694 0.999999999999997 GO:0180030 inositol phosphate kinase activity 1/2274 11/18639 0.0909090909090909 0.745142720076757 0.761081780512694 0.999999999999997 GO:0005021 vascular endothelial growth factor receptor activity 5/2274 51/18639 0.0980392156862745 0.803585286357287 0.761792043161809 0.999999999999997 GO:0033293 monocarboxylic acid binding 8/2274 79/18639 0.10126582278481 0.830032397047527 0.763101952347294 0.999999999999997 GO:0070717 poly-purine tract binding 3/2274 32/18639 0.09375 0.768428430079156 0.766595251815067 0.999999999999997 GO:0160041 neuropeptide activity 3/2274 32/18639 0.09375 0.768428430079156 0.766595251815067 0.999999999999997 GO:0008970 phospholipase A1 activity 2/2274 22/18639 0.0909090909090909 0.745142720076757 0.768403039085383 0.999999999999997 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 2/2274 22/18639 0.0909090909090909 0.745142720076757 0.768403039085383 0.999999999999997 GO:0030021 extracellular matrix structural constituent conferring compression resistance 2/2274 22/18639 0.0909090909090909 0.745142720076757 0.768403039085383 0.999999999999997 GO:0031492 nucleosomal DNA binding 4/2274 42/18639 0.0952380952380952 0.780625706747079 0.77058186205361 0.999999999999997 GO:0035198 miRNA binding 4/2274 42/18639 0.0952380952380952 0.780625706747079 0.77058186205361 0.999999999999997 GO:0048487 beta-tubulin binding 4/2274 42/18639 0.0952380952380952 0.780625706747079 0.77058186205361 0.999999999999997 GO:0048306 calcium-dependent protein binding 8/2274 80/18639 0.1 0.819656992084433 0.775267435577336 0.999999999999997 GO:0140299 molecular sensor activity 7/2274 71/18639 0.0985915492957746 0.808112527407187 0.778713226797326 0.999999999999997 GO:0019955 cytokine binding 15/2274 144/18639 0.104166666666667 0.853809366754617 0.77996698062663 0.999999999999997 GO:0030296 protein tyrosine kinase activator activity 3/2274 33/18639 0.0909090909090909 0.745142720076757 0.784774371909944 0.999999999999997 GO:0003887 DNA-directed DNA polymerase activity 2/2274 23/18639 0.0869565217391304 0.712745210508202 0.78971634555297 0.999999999999997 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 2/2274 23/18639 0.0869565217391304 0.712745210508202 0.78971634555297 0.999999999999997 GO:0005158 insulin receptor binding 2/2274 23/18639 0.0869565217391304 0.712745210508202 0.78971634555297 0.999999999999997 GO:0005212 structural constituent of eye lens 2/2274 23/18639 0.0869565217391304 0.712745210508202 0.78971634555297 0.999999999999997 GO:0005283 amino acid:sodium symporter activity 2/2274 23/18639 0.0869565217391304 0.712745210508202 0.78971634555297 0.999999999999997 GO:0031681 G-protein beta-subunit binding 2/2274 23/18639 0.0869565217391304 0.712745210508202 0.78971634555297 0.999999999999997 GO:0043274 phospholipase binding 2/2274 23/18639 0.0869565217391304 0.712745210508202 0.78971634555297 0.999999999999997 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 2/2274 23/18639 0.0869565217391304 0.712745210508202 0.78971634555297 0.999999999999997 GO:0000995 RNA polymerase III general transcription initiation factor activity 1/2274 12/18639 0.0833333333333333 0.683047493403694 0.790247554139177 0.999999999999997 GO:0004032 aldose reductase (NADPH) activity 1/2274 12/18639 0.0833333333333333 0.683047493403694 0.790247554139177 0.999999999999997 GO:0004859 phospholipase inhibitor activity 1/2274 12/18639 0.0833333333333333 0.683047493403694 0.790247554139177 0.999999999999997 GO:0004875 complement receptor activity 1/2274 12/18639 0.0833333333333333 0.683047493403694 0.790247554139177 0.999999999999997 GO:0005025 transforming growth factor beta receptor activity, type I 1/2274 12/18639 0.0833333333333333 0.683047493403694 0.790247554139177 0.999999999999997 GO:0005026 transforming growth factor beta receptor activity, type II 1/2274 12/18639 0.0833333333333333 0.683047493403694 0.790247554139177 0.999999999999997 GO:0005078 MAP-kinase scaffold activity 1/2274 12/18639 0.0833333333333333 0.683047493403694 0.790247554139177 0.999999999999997 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 1/2274 12/18639 0.0833333333333333 0.683047493403694 0.790247554139177 0.999999999999997 GO:0008504 monoamine transmembrane transporter activity 1/2274 12/18639 0.0833333333333333 0.683047493403694 0.790247554139177 0.999999999999997 GO:0010853 cyclase activator activity 1/2274 12/18639 0.0833333333333333 0.683047493403694 0.790247554139177 0.999999999999997 GO:0015166 polyol transmembrane transporter activity 1/2274 12/18639 0.0833333333333333 0.683047493403694 0.790247554139177 0.999999999999997 GO:0015269 calcium-activated potassium channel activity 1/2274 12/18639 0.0833333333333333 0.683047493403694 0.790247554139177 0.999999999999997 GO:0016361 activin receptor activity, type I 1/2274 12/18639 0.0833333333333333 0.683047493403694 0.790247554139177 0.999999999999997 GO:0016362 activin receptor activity, type II 1/2274 12/18639 0.0833333333333333 0.683047493403694 0.790247554139177 0.999999999999997 GO:0017002 activin receptor activity 1/2274 12/18639 0.0833333333333333 0.683047493403694 0.790247554139177 0.999999999999997 GO:0035251 UDP-glucosyltransferase activity 1/2274 12/18639 0.0833333333333333 0.683047493403694 0.790247554139177 0.999999999999997 GO:0035497 cAMP response element binding 1/2274 12/18639 0.0833333333333333 0.683047493403694 0.790247554139177 0.999999999999997 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 1/2274 12/18639 0.0833333333333333 0.683047493403694 0.790247554139177 0.999999999999997 GO:0070008 serine-type exopeptidase activity 1/2274 12/18639 0.0833333333333333 0.683047493403694 0.790247554139177 0.999999999999997 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 1/2274 12/18639 0.0833333333333333 0.683047493403694 0.790247554139177 0.999999999999997 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 1/2274 12/18639 0.0833333333333333 0.683047493403694 0.790247554139177 0.999999999999997 GO:0140829 bicarbonate:monoatomic anion antiporter activity 1/2274 12/18639 0.0833333333333333 0.683047493403694 0.790247554139177 0.999999999999997 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 1/2274 12/18639 0.0833333333333333 0.683047493403694 0.790247554139177 0.999999999999997 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 1/2274 12/18639 0.0833333333333333 0.683047493403694 0.790247554139177 0.999999999999997 GO:0140900 chloride:bicarbonate antiporter activity 1/2274 12/18639 0.0833333333333333 0.683047493403694 0.790247554139177 0.999999999999997 GO:0141221 histone deacetylase activity, hydrolytic mechanism 1/2274 12/18639 0.0833333333333333 0.683047493403694 0.790247554139177 0.999999999999997 GO:1990459 transferrin receptor binding 1/2274 12/18639 0.0833333333333333 0.683047493403694 0.790247554139177 0.999999999999997 GO:0005246 calcium channel regulator activity 5/2274 53/18639 0.0943396226415094 0.773261313287201 0.79092406243435 0.999999999999997 GO:0005544 calcium-dependent phospholipid binding 5/2274 53/18639 0.0943396226415094 0.773261313287201 0.79092406243435 0.999999999999997 GO:0017046 peptide hormone binding 5/2274 53/18639 0.0943396226415094 0.773261313287201 0.79092406243435 0.999999999999997 GO:0034212 protein N-acetyltransferase activity 5/2274 53/18639 0.0943396226415094 0.773261313287201 0.79092406243435 0.999999999999997 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 5/2274 53/18639 0.0943396226415094 0.773261313287201 0.79092406243435 0.999999999999997 GO:0008376 acetylgalactosaminyltransferase activity 3/2274 34/18639 0.0882352941176471 0.723226757721558 0.801764287724031 0.999999999999997 GO:0016831 carboxy-lyase activity 3/2274 34/18639 0.0882352941176471 0.723226757721558 0.801764287724031 0.999999999999997 GO:0051427 hormone receptor binding 3/2274 34/18639 0.0882352941176471 0.723226757721558 0.801764287724031 0.999999999999997 GO:0052866 phosphatidylinositol phosphate phosphatase activity 3/2274 34/18639 0.0882352941176471 0.723226757721558 0.801764287724031 0.999999999999997 GO:0008094 ATP-dependent activity, acting on DNA 22/2274 210/18639 0.104761904761905 0.858688277421787 0.80727183024676 0.999999999999997 GO:0005315 phosphate transmembrane transporter activity 2/2274 24/18639 0.0833333333333333 0.683047493403694 0.809279008318244 0.999999999999997 GO:0015149 hexose transmembrane transporter activity 2/2274 24/18639 0.0833333333333333 0.683047493403694 0.809279008318244 0.999999999999997 GO:0030215 semaphorin receptor binding 2/2274 24/18639 0.0833333333333333 0.683047493403694 0.809279008318244 0.999999999999997 GO:0055056 D-glucose transmembrane transporter activity 2/2274 24/18639 0.0833333333333333 0.683047493403694 0.809279008318244 0.999999999999997 GO:0060229 lipase activator activity 2/2274 24/18639 0.0833333333333333 0.683047493403694 0.809279008318244 0.999999999999997 GO:0070840 dynein complex binding 2/2274 24/18639 0.0833333333333333 0.683047493403694 0.809279008318244 0.999999999999997 GO:0140612 DNA damage sensor activity 2/2274 24/18639 0.0833333333333333 0.683047493403694 0.809279008318244 0.999999999999997 GO:0008238 exopeptidase activity 10/2274 102/18639 0.0980392156862745 0.803585286357287 0.812280428467676 0.999999999999997 GO:0016791 phosphatase activity 29/2274 273/18639 0.106227106227106 0.870697903679434 0.813606581661533 0.999999999999997 GO:0046915 transition metal ion transmembrane transporter activity 4/2274 45/18639 0.0888888888888889 0.72858399296394 0.815676700553888 0.999999999999997 GO:0004465 lipoprotein lipase activity 1/2274 13/18639 0.0769230769230769 0.630505378526487 0.815854311098833 0.999999999999997 GO:0005035 death receptor activity 1/2274 13/18639 0.0769230769230769 0.630505378526487 0.815854311098833 0.999999999999997 GO:0005338 nucleotide-sugar transmembrane transporter activity 1/2274 13/18639 0.0769230769230769 0.630505378526487 0.815854311098833 0.999999999999997 GO:0031432 titin binding 1/2274 13/18639 0.0769230769230769 0.630505378526487 0.815854311098833 0.999999999999997 GO:0051011 microtubule minus-end binding 1/2274 13/18639 0.0769230769230769 0.630505378526487 0.815854311098833 0.999999999999997 GO:0070123 transforming growth factor beta receptor activity, type III 1/2274 13/18639 0.0769230769230769 0.630505378526487 0.815854311098833 0.999999999999997 GO:0089720 caspase binding 1/2274 13/18639 0.0769230769230769 0.630505378526487 0.815854311098833 0.999999999999997 GO:0140333 glycerophospholipid flippase activity 1/2274 13/18639 0.0769230769230769 0.630505378526487 0.815854311098833 0.999999999999997 GO:0140410 monoatomic cation:bicarbonate symporter activity 1/2274 13/18639 0.0769230769230769 0.630505378526487 0.815854311098833 0.999999999999997 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 1/2274 13/18639 0.0769230769230769 0.630505378526487 0.815854311098833 0.999999999999997 GO:0098632 cell-cell adhesion mediator activity 5/2274 55/18639 0.0909090909090909 0.745142720076757 0.817194629557405 0.999999999999997 GO:0004623 phospholipase A2 activity 3/2274 35/18639 0.0857142857142857 0.702563136072371 0.817612600823413 0.999999999999997 GO:0005343 organic acid:sodium symporter activity 3/2274 35/18639 0.0857142857142857 0.702563136072371 0.817612600823413 0.999999999999997 GO:0004252 serine-type endopeptidase activity 18/2274 176/18639 0.102272727272727 0.838285560086352 0.820025564029004 0.999999999999997 GO:0038024 cargo receptor activity 6/2274 65/18639 0.0923076923076923 0.756606454231784 0.820450432501891 0.999999999999997 GO:0042562 hormone binding 9/2274 94/18639 0.0957446808510638 0.78477797114467 0.824949302000678 0.999999999999997 GO:0001848 complement binding 2/2274 25/18639 0.08 0.655725593667546 0.82720074591123 0.999999999999997 GO:0005251 delayed rectifier potassium channel activity 2/2274 25/18639 0.08 0.655725593667546 0.82720074591123 0.999999999999997 GO:0008483 transaminase activity 2/2274 25/18639 0.08 0.655725593667546 0.82720074591123 0.999999999999997 GO:0015271 outward rectifier potassium channel activity 2/2274 25/18639 0.08 0.655725593667546 0.82720074591123 0.999999999999997 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 2/2274 25/18639 0.08 0.655725593667546 0.82720074591123 0.999999999999997 GO:0017056 structural constituent of nuclear pore 2/2274 25/18639 0.08 0.655725593667546 0.82720074591123 0.999999999999997 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 2/2274 25/18639 0.08 0.655725593667546 0.82720074591123 0.999999999999997 GO:0120020 cholesterol transfer activity 2/2274 25/18639 0.08 0.655725593667546 0.82720074591123 0.999999999999997 GO:0004180 carboxypeptidase activity 4/2274 46/18639 0.0869565217391304 0.712745210508202 0.82899034884418 0.999999999999997 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 4/2274 46/18639 0.0869565217391304 0.712745210508202 0.82899034884418 0.999999999999997 GO:0030170 pyridoxal phosphate binding 5/2274 56/18639 0.0892857142857143 0.731836600075386 0.829299590416461 0.999999999999997 GO:0005179 hormone activity 13/2274 132/18639 0.0984848484848485 0.80723794674982 0.831644738289858 0.999999999999997 GO:0000993 RNA polymerase II complex binding 3/2274 36/18639 0.0833333333333333 0.683047493403694 0.832369556683065 0.999999999999997 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 3/2274 36/18639 0.0833333333333333 0.683047493403694 0.832369556683065 0.999999999999997 GO:0044390 ubiquitin-like protein conjugating enzyme binding 3/2274 36/18639 0.0833333333333333 0.683047493403694 0.832369556683065 0.999999999999997 GO:0045505 dynein intermediate chain binding 3/2274 36/18639 0.0833333333333333 0.683047493403694 0.832369556683065 0.999999999999997 GO:0004705 JUN kinase activity 1/2274 14/18639 0.0714285714285714 0.585469280060309 0.838336180344042 0.999999999999997 GO:0005344 oxygen carrier activity 1/2274 14/18639 0.0714285714285714 0.585469280060309 0.838336180344042 0.999999999999997 GO:0008494 translation activator activity 1/2274 14/18639 0.0714285714285714 0.585469280060309 0.838336180344042 0.999999999999997 GO:0015926 glucosidase activity 1/2274 14/18639 0.0714285714285714 0.585469280060309 0.838336180344042 0.999999999999997 GO:0032454 histone H3K9 demethylase activity 1/2274 14/18639 0.0714285714285714 0.585469280060309 0.838336180344042 0.999999999999997 GO:0061665 SUMO ligase activity 1/2274 14/18639 0.0714285714285714 0.585469280060309 0.838336180344042 0.999999999999997 GO:0070742 C2H2 zinc finger domain binding 1/2274 14/18639 0.0714285714285714 0.585469280060309 0.838336180344042 0.999999999999997 GO:0098821 BMP receptor activity 1/2274 14/18639 0.0714285714285714 0.585469280060309 0.838336180344042 0.999999999999997 GO:1901474 azole transmembrane transporter activity 1/2274 14/18639 0.0714285714285714 0.585469280060309 0.838336180344042 0.999999999999997 GO:1990825 sequence-specific mRNA binding 1/2274 14/18639 0.0714285714285714 0.585469280060309 0.838336180344042 0.999999999999997 GO:0070279 vitamin B6 binding 5/2274 57/18639 0.087719298245614 0.718997361477573 0.840743981859281 0.999999999999997 GO:0005267 potassium channel activity 12/2274 124/18639 0.0967741935483871 0.793216443952677 0.841457691016063 0.999999999999997 GO:0001784 phosphotyrosine residue binding 4/2274 47/18639 0.0851063829787234 0.697580418795262 0.841494003417796 0.999999999999997 GO:0016500 protein-hormone receptor activity 6/2274 67/18639 0.0895522388059701 0.734021186941283 0.84207398013292 0.999999999999997 GO:0004112 cyclic-nucleotide phosphodiesterase activity 2/2274 26/18639 0.0769230769230769 0.630505378526487 0.843590573222246 0.999999999999997 GO:0004529 DNA exonuclease activity 2/2274 26/18639 0.0769230769230769 0.630505378526487 0.843590573222246 0.999999999999997 GO:0005227 calcium-activated cation channel activity 2/2274 26/18639 0.0769230769230769 0.630505378526487 0.843590573222246 0.999999999999997 GO:0015145 monosaccharide transmembrane transporter activity 2/2274 26/18639 0.0769230769230769 0.630505378526487 0.843590573222246 0.999999999999997 GO:0019865 immunoglobulin binding 2/2274 26/18639 0.0769230769230769 0.630505378526487 0.843590573222246 0.999999999999997 GO:0034237 protein kinase A regulatory subunit binding 2/2274 26/18639 0.0769230769230769 0.630505378526487 0.843590573222246 0.999999999999997 GO:0043548 phosphatidylinositol 3-kinase binding 2/2274 26/18639 0.0769230769230769 0.630505378526487 0.843590573222246 0.999999999999997 GO:0017116 single-stranded DNA helicase activity 5/2274 58/18639 0.0862068965517241 0.706600855245201 0.851549188341902 0.999999999999997 GO:0140223 general transcription initiation factor activity 6/2274 68/18639 0.0882352941176471 0.723226757721558 0.852067034662583 0.999999999999997 GO:0140693 molecular condensate scaffold activity 4/2274 48/18639 0.0833333333333333 0.683047493403694 0.85321945051586 0.999999999999997 GO:0019199 transmembrane receptor protein kinase activity 7/2274 78/18639 0.0897435897435897 0.735589608280901 0.853875899681749 0.999999999999997 GO:0004197 cysteine-type endopeptidase activity 8/2274 88/18639 0.0909090909090909 0.745142720076757 0.856470452664418 0.999999999999997 GO:0004467 long-chain fatty acid-CoA ligase activity 1/2274 15/18639 0.0666666666666667 0.546437994722955 0.858074356231164 0.999999999999997 GO:0004953 icosanoid receptor activity 1/2274 15/18639 0.0666666666666667 0.546437994722955 0.858074356231164 0.999999999999997 GO:0005041 low-density lipoprotein particle receptor activity 1/2274 15/18639 0.0666666666666667 0.546437994722955 0.858074356231164 0.999999999999997 GO:0015250 water channel activity 1/2274 15/18639 0.0666666666666667 0.546437994722955 0.858074356231164 0.999999999999997 GO:0017081 chloride channel regulator activity 1/2274 15/18639 0.0666666666666667 0.546437994722955 0.858074356231164 0.999999999999997 GO:0042809 nuclear vitamin D receptor binding 1/2274 15/18639 0.0666666666666667 0.546437994722955 0.858074356231164 0.999999999999997 GO:0045504 dynein heavy chain binding 1/2274 15/18639 0.0666666666666667 0.546437994722955 0.858074356231164 0.999999999999997 GO:0047372 monoacylglycerol lipase activity 1/2274 15/18639 0.0666666666666667 0.546437994722955 0.858074356231164 0.999999999999997 GO:0120283 protein serine/threonine kinase binding 1/2274 15/18639 0.0666666666666667 0.546437994722955 0.858074356231164 0.999999999999997 GO:0140776 protein-containing complex destabilizing activity 1/2274 15/18639 0.0666666666666667 0.546437994722955 0.858074356231164 0.999999999999997 GO:0000146 microfilament motor activity 3/2274 38/18639 0.0789473684210526 0.647097625329815 0.858818143557878 0.999999999999997 GO:0005501 retinoid binding 3/2274 38/18639 0.0789473684210526 0.647097625329815 0.858818143557878 0.999999999999997 GO:0019840 isoprenoid binding 3/2274 38/18639 0.0789473684210526 0.647097625329815 0.858818143557878 0.999999999999997 GO:0016279 protein-lysine N-methyltransferase activity 6/2274 69/18639 0.0869565217391304 0.712745210508202 0.861535920033275 0.999999999999997 GO:0098960 postsynaptic neurotransmitter receptor activity 6/2274 69/18639 0.0869565217391304 0.712745210508202 0.861535920033275 0.999999999999997 GO:0070063 RNA polymerase binding 5/2274 59/18639 0.0847457627118644 0.694624569563079 0.861737575356496 0.999999999999997 GO:0005004 GPI-linked ephrin receptor activity 4/2274 49/18639 0.0816326530612245 0.669107748640353 0.864199445686999 0.999999999999997 GO:0005008 hepatocyte growth factor receptor activity 4/2274 49/18639 0.0816326530612245 0.669107748640353 0.864199445686999 0.999999999999997 GO:0005009 insulin receptor activity 4/2274 49/18639 0.0816326530612245 0.669107748640353 0.864199445686999 0.999999999999997 GO:0005011 macrophage colony-stimulating factor receptor activity 4/2274 49/18639 0.0816326530612245 0.669107748640353 0.864199445686999 0.999999999999997 GO:0005018 platelet-derived growth factor alpha-receptor activity 4/2274 49/18639 0.0816326530612245 0.669107748640353 0.864199445686999 0.999999999999997 GO:0005020 stem cell factor receptor activity 4/2274 49/18639 0.0816326530612245 0.669107748640353 0.864199445686999 0.999999999999997 GO:0008288 boss receptor activity 4/2274 49/18639 0.0816326530612245 0.669107748640353 0.864199445686999 0.999999999999997 GO:0036332 placental growth factor receptor activity 4/2274 49/18639 0.0816326530612245 0.669107748640353 0.864199445686999 0.999999999999997 GO:0038062 protein tyrosine kinase collagen receptor activity 4/2274 49/18639 0.0816326530612245 0.669107748640353 0.864199445686999 0.999999999999997 GO:0060175 brain-derived neurotrophic factor receptor activity 4/2274 49/18639 0.0816326530612245 0.669107748640353 0.864199445686999 0.999999999999997 GO:0003727 single-stranded RNA binding 8/2274 89/18639 0.0898876404494382 0.736770329963535 0.864720932601592 0.999999999999997 GO:0031490 chromatin DNA binding 12/2274 128/18639 0.09375 0.768428430079156 0.870075261513286 0.999999999999997 GO:0016278 lysine N-methyltransferase activity 6/2274 70/18639 0.0857142857142857 0.702563136072371 0.870497755388179 0.999999999999997 GO:0016782 transferase activity, transferring sulphur-containing groups 6/2274 70/18639 0.0857142857142857 0.702563136072371 0.870497755388179 0.999999999999997 GO:0000217 DNA secondary structure binding 3/2274 39/18639 0.0769230769230769 0.630505378526487 0.870615767632134 0.999999999999997 GO:0035091 phosphatidylinositol binding 29/2274 284/18639 0.102112676056338 0.836973689100301 0.870882859431262 0.999999999999997 GO:0045499 chemorepellent activity 2/2274 28/18639 0.0714285714285714 0.585469280060309 0.872198639489823 0.999999999999997 GO:0050698 proteoglycan sulfotransferase activity 2/2274 28/18639 0.0714285714285714 0.585469280060309 0.872198639489823 0.999999999999997 GO:0051019 mitogen-activated protein kinase binding 2/2274 28/18639 0.0714285714285714 0.585469280060309 0.872198639489823 0.999999999999997 GO:0005007 fibroblast growth factor receptor activity 4/2274 50/18639 0.08 0.655725593667546 0.874467334615663 0.999999999999997 GO:0005017 platelet-derived growth factor receptor activity 4/2274 50/18639 0.08 0.655725593667546 0.874467334615663 0.999999999999997 GO:0005019 platelet-derived growth factor beta-receptor activity 4/2274 50/18639 0.08 0.655725593667546 0.874467334615663 0.999999999999997 GO:0008236 serine-type peptidase activity 19/2274 194/18639 0.0979381443298969 0.802756847917743 0.874935152186722 0.999999999999997 GO:0004707 MAP kinase activity 1/2274 16/18639 0.0625 0.51228562005277 0.875403550492887 0.999999999999997 GO:0004708 MAP kinase kinase activity 1/2274 16/18639 0.0625 0.51228562005277 0.875403550492887 0.999999999999997 GO:0005024 transforming growth factor beta receptor activity 1/2274 16/18639 0.0625 0.51228562005277 0.875403550492887 0.999999999999997 GO:0005324 long-chain fatty acid transmembrane transporter activity 1/2274 16/18639 0.0625 0.51228562005277 0.875403550492887 0.999999999999997 GO:0008296 3'-5'-DNA exonuclease activity 1/2274 16/18639 0.0625 0.51228562005277 0.875403550492887 0.999999999999997 GO:0015378 sodium:chloride symporter activity 1/2274 16/18639 0.0625 0.51228562005277 0.875403550492887 0.999999999999997 GO:0015385 sodium:proton antiporter activity 1/2274 16/18639 0.0625 0.51228562005277 0.875403550492887 0.999999999999997 GO:0031435 mitogen-activated protein kinase kinase kinase binding 1/2274 16/18639 0.0625 0.51228562005277 0.875403550492887 0.999999999999997 GO:0055102 lipase inhibitor activity 1/2274 16/18639 0.0625 0.51228562005277 0.875403550492887 0.999999999999997 GO:0097027 ubiquitin-protein transferase activator activity 1/2274 16/18639 0.0625 0.51228562005277 0.875403550492887 0.999999999999997 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 1/2274 16/18639 0.0625 0.51228562005277 0.875403550492887 0.999999999999997 GO:0140327 flippase activity 1/2274 16/18639 0.0625 0.51228562005277 0.875403550492887 0.999999999999997 GO:0140328 floppase activity 1/2274 16/18639 0.0625 0.51228562005277 0.875403550492887 0.999999999999997 GO:0015026 coreceptor activity 5/2274 61/18639 0.0819672131147541 0.67184999351183 0.880356764062046 0.999999999999997 GO:0005010 insulin-like growth factor receptor activity 4/2274 51/18639 0.0784313725490196 0.64286822908583 0.884056721122374 0.999999999999997 GO:0005030 neurotrophin receptor activity 4/2274 51/18639 0.0784313725490196 0.64286822908583 0.884056721122374 0.999999999999997 GO:0016597 amino acid binding 4/2274 51/18639 0.0784313725490196 0.64286822908583 0.884056721122374 0.999999999999997 GO:0016830 carbon-carbon lyase activity 4/2274 51/18639 0.0784313725490196 0.64286822908583 0.884056721122374 0.999999999999997 GO:0004181 metallocarboxypeptidase activity 2/2274 29/18639 0.0689655172413793 0.56528068419616 0.884620007389074 0.999999999999997 GO:0005416 amino acid:monoatomic cation symporter activity 2/2274 29/18639 0.0689655172413793 0.56528068419616 0.884620007389074 0.999999999999997 GO:0016417 S-acyltransferase activity 2/2274 29/18639 0.0689655172413793 0.56528068419616 0.884620007389074 0.999999999999997 GO:0051020 GTPase binding 32/2274 315/18639 0.101587301587302 0.832667420530217 0.887719674975711 0.999999999999997 GO:0004029 aldehyde dehydrogenase (NAD+) activity 1/2274 17/18639 0.0588235294117647 0.482151171814372 0.890617658111379 0.999999999999997 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 1/2274 17/18639 0.0588235294117647 0.482151171814372 0.890617658111379 0.999999999999997 GO:0004659 prenyltransferase activity 1/2274 17/18639 0.0588235294117647 0.482151171814372 0.890617658111379 0.999999999999997 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 1/2274 17/18639 0.0588235294117647 0.482151171814372 0.890617658111379 0.999999999999997 GO:0019198 transmembrane receptor protein phosphatase activity 1/2274 17/18639 0.0588235294117647 0.482151171814372 0.890617658111379 0.999999999999997 GO:0036041 long-chain fatty acid binding 1/2274 17/18639 0.0588235294117647 0.482151171814372 0.890617658111379 0.999999999999997 GO:0045236 CXCR chemokine receptor binding 1/2274 17/18639 0.0588235294117647 0.482151171814372 0.890617658111379 0.999999999999997 GO:0001727 lipid kinase activity 3/2274 41/18639 0.0731707317073171 0.599749018598365 0.89162122370866 0.999999999999997 GO:0004812 aminoacyl-tRNA ligase activity 3/2274 41/18639 0.0731707317073171 0.599749018598365 0.89162122370866 0.999999999999997 GO:0008227 G protein-coupled amine receptor activity 3/2274 41/18639 0.0731707317073171 0.599749018598365 0.89162122370866 0.999999999999997 GO:0016875 ligase activity, forming carbon-oxygen bonds 3/2274 41/18639 0.0731707317073171 0.599749018598365 0.89162122370866 0.999999999999997 GO:0042287 MHC protein binding 3/2274 41/18639 0.0731707317073171 0.599749018598365 0.89162122370866 0.999999999999997 GO:0017171 serine hydrolase activity 19/2274 198/18639 0.095959595959596 0.786539537858799 0.894717125209673 0.999999999999997 GO:0022839 monoatomic ion-gated channel activity 2/2274 30/18639 0.0666666666666667 0.546437994722955 0.895914374767213 0.999999999999997 GO:0070566 adenylyltransferase activity 2/2274 30/18639 0.0666666666666667 0.546437994722955 0.895914374767213 0.999999999999997 GO:0022824 transmitter-gated monoatomic ion channel activity 5/2274 63/18639 0.0793650793650794 0.650521422289232 0.896791080103512 0.999999999999997 GO:0022835 transmitter-gated channel activity 5/2274 63/18639 0.0793650793650794 0.650521422289232 0.896791080103512 0.999999999999997 GO:0016410 N-acyltransferase activity 8/2274 94/18639 0.0851063829787234 0.697580418795262 0.900358872930505 0.999999999999997 GO:0043175 RNA polymerase core enzyme binding 3/2274 42/18639 0.0714285714285714 0.585469280060309 0.900931943835972 0.999999999999997 GO:0005003 ephrin receptor activity 4/2274 53/18639 0.0754716981132075 0.618609050629761 0.90133400493233 0.999999999999997 GO:0005005 transmembrane-ephrin receptor activity 4/2274 53/18639 0.0754716981132075 0.618609050629761 0.90133400493233 0.999999999999997 GO:0038064 collagen receptor activity 4/2274 53/18639 0.0754716981132075 0.618609050629761 0.90133400493233 0.999999999999997 GO:0000400 four-way junction DNA binding 1/2274 18/18639 0.0555555555555556 0.455364995602463 0.903974732832393 0.999999999999997 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 1/2274 18/18639 0.0555555555555556 0.455364995602463 0.903974732832393 0.999999999999997 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 1/2274 18/18639 0.0555555555555556 0.455364995602463 0.903974732832393 0.999999999999997 GO:0004706 JUN kinase kinase kinase activity 1/2274 18/18639 0.0555555555555556 0.455364995602463 0.903974732832393 0.999999999999997 GO:0005372 water transmembrane transporter activity 1/2274 18/18639 0.0555555555555556 0.455364995602463 0.903974732832393 0.999999999999997 GO:0015280 ligand-gated sodium channel activity 1/2274 18/18639 0.0555555555555556 0.455364995602463 0.903974732832393 0.999999999999997 GO:0015373 monoatomic anion:sodium symporter activity 1/2274 18/18639 0.0555555555555556 0.455364995602463 0.903974732832393 0.999999999999997 GO:0017075 syntaxin-1 binding 1/2274 18/18639 0.0555555555555556 0.455364995602463 0.903974732832393 0.999999999999997 GO:0017128 phospholipid scramblase activity 1/2274 18/18639 0.0555555555555556 0.455364995602463 0.903974732832393 0.999999999999997 GO:0032393 MHC class I receptor activity 1/2274 18/18639 0.0555555555555556 0.455364995602463 0.903974732832393 0.999999999999997 GO:0050811 GABA receptor binding 1/2274 18/18639 0.0555555555555556 0.455364995602463 0.903974732832393 0.999999999999997 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 1/2274 18/18639 0.0555555555555556 0.455364995602463 0.903974732832393 0.999999999999997 GO:0003774 cytoskeletal motor activity 14/2274 153/18639 0.0915032679738562 0.750012933933468 0.904214832113145 0.999999999999997 GO:0005164 tumor necrosis factor receptor binding 2/2274 31/18639 0.0645161290322581 0.528810962635118 0.906171707418081 0.999999999999997 GO:0008327 methyl-CpG binding 2/2274 31/18639 0.0645161290322581 0.528810962635118 0.906171707418081 0.999999999999997 GO:0016411 acylglycerol O-acyltransferase activity 2/2274 31/18639 0.0645161290322581 0.528810962635118 0.906171707418081 0.999999999999997 GO:0140457 protein demethylase activity 2/2274 31/18639 0.0645161290322581 0.528810962635118 0.906171707418081 0.999999999999997 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 22/2274 229/18639 0.0960698689956332 0.787443398509062 0.908102214113044 0.999999999999997 GO:0005085 guanyl-nucleotide exchange factor activity 22/2274 230/18639 0.0956521739130435 0.784019731559023 0.911924867018011 0.999999999999997 GO:0015106 bicarbonate transmembrane transporter activity 2/2274 32/18639 0.0625 0.51228562005277 0.915476804458282 0.999999999999997 GO:0047498 calcium-dependent phospholipase A2 activity 2/2274 32/18639 0.0625 0.51228562005277 0.915476804458282 0.999999999999997 GO:0120015 sterol transfer activity 2/2274 32/18639 0.0625 0.51228562005277 0.915476804458282 0.999999999999997 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 1/2274 19/18639 0.0526315789473684 0.431398416886544 0.915701356404658 0.999999999999997 GO:0008381 mechanosensitive monoatomic ion channel activity 1/2274 19/18639 0.0526315789473684 0.431398416886544 0.915701356404658 0.999999999999997 GO:0015245 fatty acid transmembrane transporter activity 1/2274 19/18639 0.0526315789473684 0.431398416886544 0.915701356404658 0.999999999999997 GO:0030506 ankyrin binding 1/2274 19/18639 0.0526315789473684 0.431398416886544 0.915701356404658 0.999999999999997 GO:0031420 alkali metal ion binding 1/2274 19/18639 0.0526315789473684 0.431398416886544 0.915701356404658 0.999999999999997 GO:1990380 K48-linked deubiquitinase activity 1/2274 19/18639 0.0526315789473684 0.431398416886544 0.915701356404658 0.999999999999997 GO:0008374 O-acyltransferase activity 4/2274 55/18639 0.0727272727272727 0.596114176061406 0.916295331145377 0.999999999999997 GO:0001046 core promoter sequence-specific DNA binding 3/2274 44/18639 0.0681818181818182 0.558857040057568 0.917416188836158 0.999999999999997 GO:0004725 protein tyrosine phosphatase activity 8/2274 98/18639 0.0816326530612245 0.669107748640353 0.922842384932371 0.999999999999997 GO:0042054 histone methyltransferase activity 5/2274 67/18639 0.0746268656716418 0.611684322451069 0.923868166437423 0.999999999999997 GO:0019239 deaminase activity 2/2274 33/18639 0.0606060606060606 0.496761813384505 0.9239092194614 0.999999999999997 GO:0071889 14-3-3 protein binding 2/2274 33/18639 0.0606060606060606 0.496761813384505 0.9239092194614 0.999999999999997 GO:0001972 retinoic acid binding 1/2274 20/18639 0.05 0.409828496042216 0.925996475391543 0.999999999999997 GO:0005326 neurotransmitter transmembrane transporter activity 1/2274 20/18639 0.05 0.409828496042216 0.925996475391543 0.999999999999997 GO:0015095 magnesium ion transmembrane transporter activity 1/2274 20/18639 0.05 0.409828496042216 0.925996475391543 0.999999999999997 GO:0042288 MHC class I protein binding 1/2274 20/18639 0.05 0.409828496042216 0.925996475391543 0.999999999999997 GO:0140664 ATP-dependent DNA damage sensor activity 1/2274 20/18639 0.05 0.409828496042216 0.925996475391543 0.999999999999997 GO:0140939 histone H4 methyltransferase activity 1/2274 20/18639 0.05 0.409828496042216 0.925996475391543 0.999999999999997 GO:0008234 cysteine-type peptidase activity 17/2274 187/18639 0.0909090909090909 0.745142720076757 0.92672753516333 0.999999999999997 GO:0016758 hexosyltransferase activity 18/2274 197/18639 0.0913705583756345 0.748925170432477 0.928397656798296 0.999999999999997 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 7/2274 89/18639 0.0786516853932584 0.644674038718093 0.929043732484468 0.999999999999997 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 7/2274 89/18639 0.0786516853932584 0.644674038718093 0.929043732484468 0.999999999999997 GO:0005516 calmodulin binding 19/2274 207/18639 0.0917874396135266 0.752342166647547 0.930090485599584 0.999999999999997 GO:0019825 oxygen binding 2/2274 34/18639 0.0588235294117647 0.482151171814372 0.931543277694986 0.999999999999997 GO:0090482 vitamin transmembrane transporter activity 2/2274 34/18639 0.0588235294117647 0.482151171814372 0.931543277694986 0.999999999999997 GO:0140793 histone H2AXY142 phosphatase activity 7/2274 90/18639 0.0777777777777778 0.637510993843448 0.933805579042745 0.999999999999997 GO:0061980 regulatory RNA binding 4/2274 58/18639 0.0689655172413793 0.56528068419616 0.934945848746384 0.999999999999997 GO:0001846 opsonin binding 1/2274 21/18639 0.0476190476190476 0.390312853373539 0.93503477041059 0.999999999999997 GO:0015125 bile acid transmembrane transporter activity 1/2274 21/18639 0.0476190476190476 0.390312853373539 0.93503477041059 0.999999999999997 GO:0015174 basic amino acid transmembrane transporter activity 1/2274 21/18639 0.0476190476190476 0.390312853373539 0.93503477041059 0.999999999999997 GO:0051010 microtubule plus-end binding 1/2274 21/18639 0.0476190476190476 0.390312853373539 0.93503477041059 0.999999999999997 GO:0015631 tubulin binding 38/2274 385/18639 0.0987012987012987 0.809012096083336 0.935323673386752 0.999999999999997 GO:0003697 single-stranded DNA binding 10/2274 121/18639 0.0826446280991736 0.677402472797052 0.935385192508517 0.999999999999997 GO:0042393 histone binding 23/2274 247/18639 0.0931174089068826 0.763243352953116 0.936872288493575 0.999999999999997 GO:0140359 ABC-type transporter activity 3/2274 47/18639 0.0638297872340425 0.523185314096446 0.937486743376931 0.999999999999997 GO:0005154 epidermal growth factor receptor binding 2/2274 35/18639 0.0571428571428571 0.468375424048247 0.938448167202353 0.999999999999997 GO:0034061 DNA polymerase activity 2/2274 35/18639 0.0571428571428571 0.468375424048247 0.938448167202353 0.999999999999997 GO:0140566 histone reader activity 2/2274 35/18639 0.0571428571428571 0.468375424048247 0.938448167202353 0.999999999999997 GO:0004879 nuclear receptor activity 4/2274 59/18639 0.0677966101694915 0.555699655650463 0.940270086811103 0.999999999999997 GO:0036002 pre-mRNA binding 4/2274 59/18639 0.0677966101694915 0.555699655650463 0.940270086811103 0.999999999999997 GO:0015171 amino acid transmembrane transporter activity 8/2274 102/18639 0.0784313725490196 0.64286822908583 0.940801588964967 0.999999999999997 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 25/2274 268/18639 0.0932835820895522 0.764605403063837 0.94271292300081 0.999999999999997 GO:0008093 cytoskeletal anchor activity 1/2274 22/18639 0.0454545454545455 0.372571360038379 0.942969614759409 0.999999999999997 GO:0015377 chloride:monoatomic cation symporter activity 1/2274 22/18639 0.0454545454545455 0.372571360038379 0.942969614759409 0.999999999999997 GO:0033038 bitter taste receptor activity 1/2274 22/18639 0.0454545454545455 0.372571360038379 0.942969614759409 0.999999999999997 GO:0050321 tau-protein kinase activity 1/2274 22/18639 0.0454545454545455 0.372571360038379 0.942969614759409 0.999999999999997 GO:0140784 metal ion sensor activity 1/2274 22/18639 0.0454545454545455 0.372571360038379 0.942969614759409 0.999999999999997 GO:0008188 neuropeptide receptor activity 3/2274 48/18639 0.0625 0.51228562005277 0.943104562901003 0.999999999999997 GO:0038187 pattern recognition receptor activity 3/2274 48/18639 0.0625 0.51228562005277 0.943104562901003 0.999999999999997 GO:0001217 DNA-binding transcription repressor activity 26/2274 278/18639 0.0935251798561151 0.766585676050189 0.944228559960183 0.999999999999997 GO:0004869 cysteine-type endopeptidase inhibitor activity 2/2274 36/18639 0.0555555555555556 0.455364995602463 0.944688085468194 0.999999999999997 GO:0098531 ligand-modulated transcription factor activity 4/2274 60/18639 0.0666666666666667 0.546437994722955 0.945194218987885 0.999999999999997 GO:0008237 metallopeptidase activity 16/2274 184/18639 0.0869565217391304 0.712745210508202 0.947707285825414 0.999999999999997 GO:0042379 chemokine receptor binding 5/2274 72/18639 0.0694444444444444 0.569206244503078 0.948734179075587 0.999999999999997 GO:0004721 phosphoprotein phosphatase activity 15/2274 175/18639 0.0857142857142857 0.702563136072371 0.949842340900056 0.999999999999997 GO:0016917 GABA receptor activity 1/2274 23/18639 0.0434782608695652 0.356372605254101 0.949935672450611 0.999999999999997 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 1/2274 23/18639 0.0434782608695652 0.356372605254101 0.949935672450611 0.999999999999997 GO:0070577 lysine-acetylated histone binding 1/2274 23/18639 0.0434782608695652 0.356372605254101 0.949935672450611 0.999999999999997 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 5/2274 73/18639 0.0684931506849315 0.561408898687968 0.952720590243712 0.999999999999997 GO:0048020 CCR chemokine receptor binding 3/2274 50/18639 0.06 0.49179419525066 0.952960115669494 0.999999999999997 GO:0015294 solute:monoatomic cation symporter activity 9/2274 116/18639 0.0775862068965517 0.635940769720681 0.953627663546698 0.999999999999997 GO:0015179 L-amino acid transmembrane transporter activity 4/2274 62/18639 0.0645161290322581 0.528810962635118 0.953944848250038 0.999999999999997 GO:0031267 small GTPase binding 26/2274 283/18639 0.0918727915194346 0.7530417595122 0.955184055662732 0.999999999999997 GO:0019783 ubiquitin-like protein peptidase activity 10/2274 127/18639 0.078740157480315 0.645399206365695 0.955664471234833 0.999999999999997 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 1/2274 24/18639 0.0416666666666667 0.341523746701847 0.956051179586801 0.999999999999997 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 1/2274 24/18639 0.0416666666666667 0.341523746701847 0.956051179586801 0.999999999999997 GO:0004806 triacylglycerol lipase activity 1/2274 24/18639 0.0416666666666667 0.341523746701847 0.956051179586801 0.999999999999997 GO:0050699 WW domain binding 1/2274 24/18639 0.0416666666666667 0.341523746701847 0.956051179586801 0.999999999999997 GO:0140033 acetylation-dependent protein binding 1/2274 24/18639 0.0416666666666667 0.341523746701847 0.956051179586801 0.999999999999997 GO:0003678 DNA helicase activity 5/2274 74/18639 0.0675675675675676 0.553822291948941 0.95642266496102 0.999999999999997 GO:0005048 signal sequence binding 3/2274 51/18639 0.0588235294117647 0.482151171814372 0.957266577828689 0.999999999999997 GO:0005272 sodium channel activity 3/2274 51/18639 0.0588235294117647 0.482151171814372 0.957266577828689 0.999999999999997 GO:0005319 lipid transporter activity 15/2274 178/18639 0.0842696629213483 0.690722184340814 0.957460175678566 0.999999999999997 GO:0005126 cytokine receptor binding 25/2274 275/18639 0.0909090909090909 0.745142720076757 0.95806296635451 0.999999999999997 GO:0001653 peptide receptor activity 10/2274 128/18639 0.078125 0.640357025065963 0.958431422245935 0.999999999999997 GO:0030594 neurotransmitter receptor activity 7/2274 97/18639 0.0721649484536082 0.591505045834127 0.959936246443543 0.999999999999997 GO:0008017 microtubule binding 25/2274 276/18639 0.0905797101449275 0.742442927612711 0.959936637991561 0.999999999999997 GO:0030295 protein kinase activator activity 11/2274 139/18639 0.079136690647482 0.648649418196314 0.960333959705435 0.999999999999997 GO:0035591 signaling adaptor activity 10/2274 129/18639 0.0775193798449612 0.635393017119715 0.961043630382865 0.999999999999997 GO:0030159 signaling receptor complex adaptor activity 3/2274 52/18639 0.0576923076923077 0.472879033894865 0.961201194078398 0.999999999999997 GO:0003707 nuclear steroid receptor activity 1/2274 25/18639 0.04 0.327862796833773 0.961419947656616 0.999999999999997 GO:0004709 MAP kinase kinase kinase activity 1/2274 25/18639 0.04 0.327862796833773 0.961419947656616 0.999999999999997 GO:0005537 D-mannose binding 1/2274 25/18639 0.04 0.327862796833773 0.961419947656616 0.999999999999997 GO:0015296 monoatomic anion:monoatomic cation symporter activity 1/2274 25/18639 0.04 0.327862796833773 0.961419947656616 0.999999999999997 GO:0015662 P-type ion transporter activity 1/2274 25/18639 0.04 0.327862796833773 0.961419947656616 0.999999999999997 GO:0019706 protein-cysteine S-palmitoyltransferase activity 1/2274 25/18639 0.04 0.327862796833773 0.961419947656616 0.999999999999997 GO:0019707 protein-cysteine S-acyltransferase activity 1/2274 25/18639 0.04 0.327862796833773 0.961419947656616 0.999999999999997 GO:0140358 P-type transmembrane transporter activity 1/2274 25/18639 0.04 0.327862796833773 0.961419947656616 0.999999999999997 GO:0005249 voltage-gated potassium channel activity 7/2274 98/18639 0.0714285714285714 0.585469280060309 0.962789620405941 0.999999999999997 GO:0008146 sulfotransferase activity 3/2274 53/18639 0.0566037735849057 0.46395678797232 0.964793225427163 0.999999999999997 GO:0001637 G protein-coupled chemoattractant receptor activity 1/2274 26/18639 0.0384615384615385 0.315252689263243 0.966133122633991 0.999999999999997 GO:0004950 chemokine receptor activity 1/2274 26/18639 0.0384615384615385 0.315252689263243 0.966133122633991 0.999999999999997 GO:0051139 metal cation:proton antiporter activity 1/2274 26/18639 0.0384615384615385 0.315252689263243 0.966133122633991 0.999999999999997 GO:0052742 phosphatidylinositol kinase activity 1/2274 26/18639 0.0384615384615385 0.315252689263243 0.966133122633991 0.999999999999997 GO:0070006 metalloaminopeptidase activity 1/2274 26/18639 0.0384615384615385 0.315252689263243 0.966133122633991 0.999999999999997 GO:0008235 metalloexopeptidase activity 4/2274 66/18639 0.0606060606060606 0.496761813384505 0.967707032218287 0.999999999999997 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 2/2274 41/18639 0.0487804878048781 0.399832679065577 0.967836352638124 0.999999999999997 GO:0008528 G protein-coupled peptide receptor activity 9/2274 122/18639 0.0737704918032787 0.604664994160647 0.969127898112285 0.999999999999997 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 9/2274 122/18639 0.0737704918032787 0.604664994160647 0.969127898112285 0.999999999999997 GO:0004683 calcium/calmodulin-dependent protein kinase activity 1/2274 27/18639 0.037037037037037 0.303576663734975 0.970270729636103 0.999999999999997 GO:0005104 fibroblast growth factor receptor binding 1/2274 27/18639 0.037037037037037 0.303576663734975 0.970270729636103 0.999999999999997 GO:0008266 poly(U) RNA binding 1/2274 27/18639 0.037037037037037 0.303576663734975 0.970270729636103 0.999999999999997 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 1/2274 27/18639 0.037037037037037 0.303576663734975 0.970270729636103 0.999999999999997 GO:0008194 UDP-glycosyltransferase activity 11/2274 145/18639 0.0758620689655172 0.621808752615777 0.972995508464358 0.999999999999997 GO:0003777 microtubule motor activity 4/2274 68/18639 0.0588235294117647 0.482151171814372 0.973048188724655 0.999999999999997 GO:0015297 antiporter activity 10/2274 135/18639 0.0740740740740741 0.60715332746995 0.973854753216813 0.999999999999997 GO:0005242 inward rectifier potassium channel activity 1/2274 28/18639 0.0357142857142857 0.292734640030155 0.97390302927115 0.999999999999997 GO:0008527 taste receptor activity 1/2274 28/18639 0.0357142857142857 0.292734640030155 0.97390302927115 0.999999999999997 GO:0046875 ephrin receptor binding 1/2274 28/18639 0.0357142857142857 0.292734640030155 0.97390302927115 0.999999999999997 GO:0141052 histone H3 demethylase activity 1/2274 28/18639 0.0357142857142857 0.292734640030155 0.97390302927115 0.999999999999997 GO:0005253 monoatomic anion channel activity 7/2274 103/18639 0.0679611650485437 0.55704844122243 0.974475038571559 0.999999999999997 GO:0015101 organic cation transmembrane transporter activity 5/2274 81/18639 0.0617283950617284 0.505961106224958 0.975752058475734 0.999999999999997 GO:0046943 carboxylic acid transmembrane transporter activity 15/2274 188/18639 0.0797872340425532 0.653981642620558 0.976024898042356 0.999999999999997 GO:0043014 alpha-tubulin binding 2/2274 44/18639 0.0454545454545455 0.372571360038379 0.976893231863347 0.999999999999997 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 1/2274 29/18639 0.0344827586206897 0.28264034209808 0.977091708624081 0.999999999999997 GO:0099604 ligand-gated calcium channel activity 1/2274 29/18639 0.0344827586206897 0.28264034209808 0.977091708624081 0.999999999999997 GO:0005342 organic acid transmembrane transporter activity 15/2274 189/18639 0.0793650793650794 0.650521422289232 0.977405762663088 0.999999999999997 GO:0019209 kinase activator activity 11/2274 148/18639 0.0743243243243243 0.609204521143835 0.977842810187309 0.999999999999997 GO:0008009 chemokine activity 2/2274 45/18639 0.0444444444444444 0.36429199648197 0.979321601013175 0.999999999999997 GO:0140303 intramembrane lipid transporter activity 2/2274 45/18639 0.0444444444444444 0.36429199648197 0.979321601013175 0.999999999999997 GO:0008187 poly-pyrimidine tract binding 1/2274 30/18639 0.0333333333333333 0.273218997361478 0.979890927032939 0.999999999999997 GO:0032452 histone demethylase activity 1/2274 30/18639 0.0333333333333333 0.273218997361478 0.979890927032939 0.999999999999997 GO:0015079 potassium ion transmembrane transporter activity 12/2274 160/18639 0.075 0.614742744063325 0.979941043346505 0.999999999999997 GO:0030276 clathrin binding 2/2274 46/18639 0.0434782608695652 0.356372605254101 0.981501694367895 0.999999999999997 GO:0004896 cytokine receptor activity 6/2274 96/18639 0.0625 0.51228562005277 0.981821010989176 0.999999999999997 GO:0005452 solute:inorganic anion antiporter activity 1/2274 31/18639 0.032258064516129 0.264405481317559 0.982348234353434 0.999999999999997 GO:0019905 syntaxin binding 3/2274 61/18639 0.0491803278688525 0.403109996107098 0.984107645677859 0.999999999999997 GO:0019956 chemokine binding 1/2274 33/18639 0.0303030303030303 0.248380906692252 0.986399007184274 0.999999999999997 GO:0015020 glucuronosyltransferase activity 1/2274 34/18639 0.0294117647058824 0.241075585907186 0.988061302017283 0.999999999999997 GO:0140789 histone phosphatase activity 9/2274 136/18639 0.0661764705882353 0.542420068291169 0.988763952570079 0.999999999999997 GO:0043015 gamma-tubulin binding 1/2274 35/18639 0.0285714285714286 0.234187712024124 0.989520511864781 0.999999999999997 GO:0004722 protein serine/threonine phosphatase activity 6/2274 103/18639 0.058252427184466 0.477470092476369 0.9899028561505 0.999999999999997 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 5/2274 91/18639 0.0549450549450549 0.450360984661776 0.989931027997708 0.999999999999997 GO:0101005 deubiquitinase activity 7/2274 115/18639 0.0608695652173913 0.498921647355742 0.990139287052377 0.999999999999997 GO:0008509 monoatomic anion transmembrane transporter activity 10/2274 149/18639 0.0671140939597315 0.550105363815055 0.990264997198845 0.999999999999997 GO:0005125 cytokine activity 18/2274 234/18639 0.0769230769230769 0.630505378526487 0.990403241721097 0.999999999999997 GO:0016409 palmitoyltransferase activity 1/2274 36/18639 0.0277777777777778 0.227682497801231 0.990801438333255 0.999999999999997 GO:0140767 enzyme-substrate adaptor activity 9/2274 139/18639 0.0647482014388489 0.530713160342438 0.991043236551852 0.999999999999997 GO:0030280 structural constituent of skin epidermis 1/2274 37/18639 0.027027027027027 0.221528916779576 0.991925855321385 0.999999999999997 GO:0000149 SNARE binding 6/2274 106/18639 0.0566037735849057 0.46395678797232 0.992200444576031 0.999999999999997 GO:0140463 chromatin-protein adaptor activity 2/2274 54/18639 0.037037037037037 0.303576663734975 0.992503717975343 0.999999999999997 GO:0008514 organic anion transmembrane transporter activity 21/2274 269/18639 0.0780669144981413 0.639880923188591 0.992547431122449 0.999999999999997 GO:0008028 monocarboxylic acid transmembrane transporter activity 3/2274 70/18639 0.0428571428571429 0.351281568036185 0.9937135926556 0.999999999999997 GO:0170055 lipid transmembrane transporter activity 2/2274 56/18639 0.0357142857142857 0.292734640030155 0.994036550140475 0.999999999999997 GO:0004222 metalloendopeptidase activity 6/2274 110/18639 0.0545454545454545 0.447085632046054 0.994501476109008 0.999999999999997 GO:0015293 symporter activity 9/2274 146/18639 0.0616438356164384 0.505268008819171 0.994788796362417 0.999999999999997 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 42/2274 484/18639 0.0867768595041322 0.711272596436904 0.994915794752707 0.999999999999997 GO:0140828 metal cation:monoatomic cation antiporter activity 1/2274 41/18639 0.024390243902439 0.199916339532788 0.995207408399286 0.999999999999997 GO:0016755 aminoacyltransferase activity 43/2274 496/18639 0.0866935483870968 0.71058973104094 0.99543839485033 0.999999999999997 GO:0019894 kinesin binding 1/2274 42/18639 0.0238095238095238 0.19515642668677 0.995793404382726 0.999999999999997 GO:0019787 ubiquitin-like protein transferase activity 41/2274 479/18639 0.0855949895615866 0.701585316815485 0.995922167665328 0.999999999999997 GO:0060589 nucleoside-triphosphatase regulator activity 42/2274 490/18639 0.0857142857142857 0.702563136072371 0.996163129403798 0.999999999999997 GO:0042277 peptide binding 18/2274 249/18639 0.072289156626506 0.592523126808024 0.996224037664705 0.999999999999997 GO:0005244 voltage-gated monoatomic ion channel activity 11/2274 173/18639 0.0635838150289017 0.521169185718425 0.99625321796642 0.999999999999997 GO:0004712 protein serine/threonine/tyrosine kinase activity 1/2274 43/18639 0.0232558139534884 0.190617905135915 0.996307777584516 0.999999999999997 GO:0001216 DNA-binding transcription activator activity 42/2274 491/18639 0.0855397148676171 0.701132253921511 0.996341160587239 0.999999999999997 GO:0070851 growth factor receptor binding 8/2274 139/18639 0.0575539568345324 0.471745031415501 0.996415739111064 0.999999999999997 GO:0061630 ubiquitin protein ligase activity 28/2274 353/18639 0.0793201133144476 0.650152854911165 0.996427723104763 0.999999999999997 GO:0005096 GTPase activator activity 20/2274 271/18639 0.0738007380073801 0.604912909287404 0.996448795630903 0.999999999999997 GO:0035401 histone H3Y41 kinase activity 6/2274 115/18639 0.0521739130434783 0.427647126304921 0.996476543909644 0.999999999999997 GO:0140801 histone H2AXY142 kinase activity 6/2274 115/18639 0.0521739130434783 0.427647126304921 0.996476543909644 0.999999999999997 GO:0004713 protein tyrosine kinase activity 8/2274 140/18639 0.0571428571428571 0.468375424048247 0.996701462965434 0.999999999999997 GO:0001223 transcription coactivator binding 1/2274 44/18639 0.0227272727272727 0.186285680019189 0.996759278647799 0.999999999999997 GO:0004175 endopeptidase activity 33/2274 405/18639 0.0814814814814815 0.667868660216945 0.996771551407792 0.999999999999997 GO:0022832 voltage-gated channel activity 11/2274 175/18639 0.0628571428571429 0.515212966453072 0.996778708662221 0.999999999999997 GO:0004715 non-membrane spanning protein tyrosine kinase activity 1/2274 45/18639 0.0222222222222222 0.182145998240985 0.997155589503131 0.999999999999997 GO:0042605 peptide antigen binding 1/2274 45/18639 0.0222222222222222 0.182145998240985 0.997155589503131 0.999999999999997 GO:0004842 ubiquitin-protein transferase activity 37/2274 449/18639 0.0824053452115813 0.67544117387804 0.997414573116628 0.999999999999997 GO:0022843 voltage-gated monoatomic cation channel activity 8/2274 143/18639 0.0559440559440559 0.458549366201081 0.997433994975567 0.999999999999997 GO:0030695 GTPase regulator activity 41/2274 489/18639 0.0838445807770961 0.687237968823349 0.997489028019896 0.999999999999997 GO:0008013 beta-catenin binding 5/2274 106/18639 0.0471698113207547 0.3866306566436 0.997499101553979 0.999999999999997 GO:0015370 solute:sodium symporter activity 3/2274 79/18639 0.0379746835443038 0.311262148892823 0.997580802265669 0.999999999999997 GO:0061733 protein-lysine-acetyltransferase activity 1/2274 47/18639 0.0212765957446809 0.174395104698815 0.997808791653112 0.999999999999997 GO:0061749 forked DNA-dependent helicase activity 1/2274 47/18639 0.0212765957446809 0.174395104698815 0.997808791653112 0.999999999999997 GO:1990518 single-stranded 3'-5' DNA helicase activity 1/2274 47/18639 0.0212765957446809 0.174395104698815 0.997808791653112 0.999999999999997 GO:0061659 ubiquitin-like protein ligase activity 29/2274 372/18639 0.0779569892473118 0.638979913184101 0.9978229574217 0.999999999999997 GO:0015108 chloride transmembrane transporter activity 6/2274 121/18639 0.0495867768595041 0.406441483678231 0.997956920649282 0.999999999999997 GO:0033192 calmodulin-dependent protein phosphatase activity 3/2274 81/18639 0.037037037037037 0.303576663734975 0.998049573865721 0.999999999999997 GO:0140791 histone H2AXS140 phosphatase activity 3/2274 81/18639 0.037037037037037 0.303576663734975 0.998049573865721 0.999999999999997 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 3/2274 81/18639 0.037037037037037 0.303576663734975 0.998049573865721 0.999999999999997 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 3/2274 81/18639 0.037037037037037 0.303576663734975 0.998049573865721 0.999999999999997 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 3/2274 81/18639 0.037037037037037 0.303576663734975 0.998049573865721 0.999999999999997 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 3/2274 81/18639 0.037037037037037 0.303576663734975 0.998049573865721 0.999999999999997 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 3/2274 81/18639 0.037037037037037 0.303576663734975 0.998049573865721 0.999999999999997 GO:1990439 MAP kinase serine/threonine phosphatase activity 3/2274 81/18639 0.037037037037037 0.303576663734975 0.998049573865721 0.999999999999997 GO:0009378 four-way junction helicase activity 1/2274 48/18639 0.0208333333333333 0.170761873350923 0.998076799816882 0.999999999999997 GO:0036121 double-stranded DNA helicase activity 1/2274 48/18639 0.0208333333333333 0.170761873350923 0.998076799816882 0.999999999999997 GO:0043138 3'-5' DNA helicase activity 1/2274 48/18639 0.0208333333333333 0.170761873350923 0.998076799816882 0.999999999999997 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 3/2274 82/18639 0.0365853658536585 0.299874509299183 0.99824940024707 0.999999999999997 GO:0033549 MAP kinase phosphatase activity 3/2274 82/18639 0.0365853658536585 0.299874509299183 0.99824940024707 0.999999999999997 GO:0099094 ligand-gated monoatomic cation channel activity 7/2274 136/18639 0.0514705882352941 0.421882275337576 0.998362497334831 0.999999999999997 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 3/2274 83/18639 0.036144578313253 0.296261563404012 0.998429156229061 0.999999999999997 GO:0005254 chloride channel activity 3/2274 83/18639 0.036144578313253 0.296261563404012 0.998429156229061 0.999999999999997 GO:0017018 myosin phosphatase activity 3/2274 84/18639 0.0357142857142857 0.292734640030155 0.99859080776092 0.999999999999997 GO:0005261 monoatomic cation channel activity 25/2274 341/18639 0.0733137829912024 0.600921548448998 0.998809231165681 0.999999999999997 GO:0015103 inorganic anion transmembrane transporter activity 9/2274 165/18639 0.0545454545454545 0.447085632046054 0.998893385014223 0.999999999999997 GO:0004677 DNA-dependent protein kinase activity 16/2274 246/18639 0.0650406504065041 0.533110238754103 0.998933166627333 0.999999999999997 GO:0005216 monoatomic ion channel activity 35/2274 448/18639 0.078125 0.640357025065963 0.999062788906826 0.999999999999997 GO:0140375 immune receptor activity 8/2274 156/18639 0.0512820512820513 0.420336919017658 0.999162051722658 0.999999999999997 GO:0004674 protein serine/threonine kinase activity 33/2274 433/18639 0.0762124711316397 0.624680848470815 0.999309144027597 0.999999999999997 GO:0106310 protein serine kinase activity 26/2274 361/18639 0.07202216066482 0.590334675739481 0.999339071505387 0.999999999999997 GO:0015291 secondary active transmembrane transporter activity 19/2274 287/18639 0.0662020905923345 0.54263006444614 0.999388815547067 0.999999999999997 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 15/2274 243/18639 0.0617283950617284 0.505961106224958 0.999414548303378 0.999999999999997 GO:0015276 ligand-gated monoatomic ion channel activity 10/2274 186/18639 0.0537634408602151 0.440675802195932 0.999477820958194 0.999999999999997 GO:0004843 cysteine-type deubiquitinase activity 4/2274 108/18639 0.037037037037037 0.303576663734975 0.99948073581913 0.999999999999997 GO:0004676 3-phosphoinositide-dependent protein kinase activity 15/2274 245/18639 0.0612244897959184 0.501830811480265 0.999496053507325 0.999999999999997 GO:0004711 ribosomal protein S6 kinase activity 15/2274 245/18639 0.0612244897959184 0.501830811480265 0.999496053507325 0.999999999999997 GO:0035175 histone H3S10 kinase activity 15/2274 245/18639 0.0612244897959184 0.501830811480265 0.999496053507325 0.999999999999997 GO:0035979 histone H2AXS139 kinase activity 15/2274 245/18639 0.0612244897959184 0.501830811480265 0.999496053507325 0.999999999999997 GO:0044022 histone H3S28 kinase activity 15/2274 245/18639 0.0612244897959184 0.501830811480265 0.999496053507325 0.999999999999997 GO:0044023 histone H4S1 kinase activity 15/2274 245/18639 0.0612244897959184 0.501830811480265 0.999496053507325 0.999999999999997 GO:0044024 histone H2AS1 kinase activity 15/2274 245/18639 0.0612244897959184 0.501830811480265 0.999496053507325 0.999999999999997 GO:0044025 histone H2BS14 kinase activity 15/2274 245/18639 0.0612244897959184 0.501830811480265 0.999496053507325 0.999999999999997 GO:0072354 histone H3T3 kinase activity 15/2274 245/18639 0.0612244897959184 0.501830811480265 0.999496053507325 0.999999999999997 GO:0072371 histone H2AS121 kinase activity 15/2274 245/18639 0.0612244897959184 0.501830811480265 0.999496053507325 0.999999999999997 GO:0072518 Rho-dependent protein serine/threonine kinase activity 15/2274 245/18639 0.0612244897959184 0.501830811480265 0.999496053507325 0.999999999999997 GO:0140823 histone H2BS36 kinase activity 15/2274 245/18639 0.0612244897959184 0.501830811480265 0.999496053507325 0.999999999999997 GO:0140855 histone H3S57 kinase activity 15/2274 245/18639 0.0612244897959184 0.501830811480265 0.999496053507325 0.999999999999997 GO:0140995 histone H2A kinase activity 15/2274 245/18639 0.0612244897959184 0.501830811480265 0.999496053507325 0.999999999999997 GO:0140997 histone H4 kinase activity 15/2274 245/18639 0.0612244897959184 0.501830811480265 0.999496053507325 0.999999999999997 GO:0140998 histone H2B kinase activity 15/2274 245/18639 0.0612244897959184 0.501830811480265 0.999496053507325 0.999999999999997 GO:1990244 histone H2AT120 kinase activity 15/2274 245/18639 0.0612244897959184 0.501830811480265 0.999496053507325 0.999999999999997 GO:0140857 histone H3T45 kinase activity 15/2274 246/18639 0.0609756097560976 0.499790848831971 0.999532604603428 0.999999999999997 GO:0022834 ligand-gated channel activity 10/2274 188/18639 0.0531914893617021 0.435987761747039 0.999558971448656 0.999999999999997 GO:0035402 histone H3T11 kinase activity 15/2274 247/18639 0.0607287449392713 0.497767404099858 0.99956660132271 0.999999999999997 GO:0035403 histone H3T6 kinase activity 15/2274 247/18639 0.0607287449392713 0.497767404099858 0.99956660132271 0.999999999999997 GO:0004679 AMP-activated protein kinase activity 15/2274 248/18639 0.0604838709677419 0.495760277470423 0.999598214213933 0.999999999999997 GO:0003730 mRNA 3'-UTR binding 16/2274 262/18639 0.0610687022900763 0.500553888295837 0.999669374158105 0.999999999999997 GO:0005262 calcium channel activity 5/2274 131/18639 0.0381679389312977 0.312846180184898 0.999788735346099 0.999999999999997 GO:0015085 calcium ion transmembrane transporter activity 6/2274 147/18639 0.0408163265306122 0.334553874320177 0.999828503893852 0.999999999999997 GO:0022836 gated channel activity 20/2274 318/18639 0.0628930817610063 0.515507542191467 0.999850872866324 0.999999999999997 GO:0015081 sodium ion transmembrane transporter activity 7/2274 164/18639 0.0426829268292683 0.34985359418238 0.999877340887432 0.999999999999997 GO:0035173 histone kinase activity 22/2274 360/18639 0.0611111111111111 0.500901495162709 0.999963918535436 0.999999999999997 GO:0141003 histone H2AX kinase activity 20/2274 354/18639 0.0564971751412429 0.463083046375386 0.999990122366655 0.999999999999997 GO:0140996 histone H3 kinase activity 20/2274 357/18639 0.0560224089635854 0.459191592204164 0.999992196989977 0.999999999999997 GO:0030527 structural constituent of chromatin 1/2274 98/18639 0.0102040816326531 0.0836384685800441 0.999997201618505 0.999999999999997 GO:0046873 metal ion transmembrane transporter activity 26/2274 450/18639 0.0577777777777778 0.473579595426561 0.999998690483375 0.999999999999997 GO:0003823 antigen binding 3/2274 174/18639 0.0172413793103448 0.14132017104904 0.999999957650872 0.999999999999997 GO:0045182 translation regulator activity 9/2274 356/18639 0.0252808988764045 0.207216655302244 0.999999999994558 0.999999999999997 GO:0030371 translation repressor activity 4/2274 329/18639 0.0121580547112462 0.0996543455421803 0.999999999999997 0.999999999999997