category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	79/1195	222/9376	2.79205397866486	RPS26/RPS10/RPL6/RPS6/RPL36AL/RPS3A/RACK1/RPS8/RPS12/MRPS15/RPL5/RPL13/RPL27A/RPL19/MRPS34/RPSA/RPL14/RPS24/RPL26/MRPL16/MRPL34/MRPS24/MRPL14/RPL36A/RPL13A/RPS15/MRPS33/RPS27A/MRPL2/MRPL36/RPL7A/RPL3/MRPL15/MRPL13/MRPS12/MRPL12/RPL8/MRPL18/RPL32/RPL10/MRPS30/RPL22L1/RPL17/MRPS25/RPS3/MRPL52/RPL41/RPS4X/RPL31/RPL12/MRPL10/RPS5/RPL22/RPL15/RPS7/RPS25/RPL21/MRPL46/MRPL45/RPL30/FAU/RPL24/RPL10A/RPS16/RPS18/RPS15A/RPS9/UBA52/RPL7/RPS23/RPL35A/RPL9/RPL11/RPS13/RPS20/RPS19/RPL23A/RPLP1/RPS2	10.3273409371495
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	73/1195	238/9376	2.40655391863859	RPS26/RPS10/PLCG2/RPL6/RPS6/NFKBIB/RPL36AL/RPS3A/RPS8/RPS12/RPL5/RPL13/RPL27A/RPL19/RPSA/RPL14/RPS24/C2/RPL26/RPL36A/RPL13A/RPS15/RPS27A/RPL7A/TLR4/RPL3/RPL8/CGAS/RPL32/RPL10/RPL22L1/RPL17/RPS3/IRF3/RPL41/IFNAR2/RPS4X/C3/RPL31/RPL12/RPS5/RPL22/RPL15/RPS7/RPS25/CFD/RPL21/NRP1/RPL30/FAU/RPL24/IRAK1/RPL10A/RPS16/RPS18/RPS15A/RPS9/UBA52/JUN/RPL7/RPS23/TYK2/RPL35A/RPL9/RPL11/RPS13/RPS20/RPS19/RPL23A/RPLP1/C6/C5AR1/RPS2	8.40012369352262
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	68/1195	227/9376	2.35035113265626	MT-ND2/MT-ND1/MT-ATP8/MT-ATP6/MT-ND4/MT-CYB/MAP2K2/GSTM5/EPHX1/MT-ND5/NDUFB7/COX4I1/BAD/MT-ND6/UQCRH/NDUFS3/NDUFB9/NDUFB11/SLC25A6/GSTM3/HGF/COX6B1/ATP5MC3/ATP5MC1/NDUFB5/AKR1A1/ATP5PD/COX6A1/COX5A/NDUFB10/NDUFA11/COX7A1/NDUFV3/NDUFS8/GSTO1/MAP3K5/UQCRFS1/NDUFS6/CYBA/CBR1/COX8A/SLC25A5/COX5B/VDAC1/GSTM1/VDAC2/ATP5PO/NDUFB2/ATP5PB/NDUFB3/NDUFA13/ATP5F1D/NFE2L2/UQCR11/GSTM2/CYP1B1/GSTM4/MAP2K7/COX7C/JUN/ATP5MC2/MT-ND4L/EPHX2/VEGFA/PLD2/PLD1/MGST2/AS3MT	7.87116873228149
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	76/1195	268/9376	2.2249921938425	MT-ND2/MT-ND1/MT-ATP8/MT-ATP6/MT-ND4/MT-CYB/BAX/MT-ND5/NDUFB7/COX4I1/MT-ND6/UQCRH/NDUFS3/NDUFB9/CYCS/NDUFB11/SLC25A6/PSMC5/PSMB6/COX6B1/PSMD4/HSPA5/UBE2G2/RPS27A/ATP5MC3/ATP5MC1/PSMD8/NDUFB5/PARK7/PSMD12/ATP5PD/PSMC3/COX6A1/COX5A/NDUFB10/NDUFA11/COX7A1/NDUFV3/NDUFS8/PSMD13/MAP3K5/XBP1/UQCRFS1/ATF4/NDUFS6/SLC39A6/COX8A/SLC25A5/SLC39A4/COX5B/VDAC1/VDAC2/ATP5PO/NDUFB2/ATP5PB/NDUFB3/PSMD6/NDUFA13/ATP5F1D/ITPR3/NFE2L2/PINK1/UQCR11/SEPTIN5/TRAP1/COX7C/TXN/UBA52/ATP5MC2/MT-ND4L/CAMK2G/GNAL/TH/UCHL1/SLC39A8/KLC2	7.77598835897635
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	48/1195	138/9376	2.72905221029653	MT-ND2/MT-ND1/MT-ATP8/MT-ATP6/MT-ND4/MT-CYB/MT-ND5/NDUFB7/COX4I1/MT-ND6/UQCRH/NDUFS3/NDUFB9/CYCS/NDUFB11/ATP6V0C/COX6B1/ATP6V0D1/ATP5MC3/ATP5MC1/NDUFB5/ATP5PD/COX6A1/COX5A/NDUFB10/NDUFA11/COX7A1/NDUFV3/NDUFS8/UQCRFS1/NDUFS6/COX8A/COX5B/ATP5PO/ATP6V1E2/NDUFB2/ATP5PB/NDUFB3/ATP6V0A2/NDUFA13/ATP5F1D/UQCR11/COX10/COX7C/ATP5MC2/MT-ND4L/ATP6V1G2/ATP6V1C2	7.82032975628295
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	58/1195	205/9376	2.21985100520461	MT-ND2/MT-ND1/MT-ATP8/MT-ATP6/MT-ND4/MT-CYB/MT-ND5/NDUFB7/COX4I1/GAPDH/MT-ND6/UQCRH/NDUFS3/NDUFB9/NDUFB11/SLC25A6/COX6B1/PARP1/ATP5MC3/ATP5MC1/NDUFB5/ATP5PD/COX6A1/COX5A/NDUFB10/NDUFA11/COX7A1/TGFB2/NDUFV3/NDUFS8/TBC1D4/UQCRFS1/NDUFS6/CYBA/COX8A/SLC25A5/COX5B/VDAC1/VDAC2/IRS1/ATP5PO/PDK3/PDHA1/NDUFB2/ATP5PB/NDUFB3/CTSD/NDUFA13/ATP5F1D/UQCR11/COX7C/ATP5MC2/MT-ND4L/CAMK2G/TGFB3/PRKCZ/ATP2A1/AGER	6.74903634197355
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	105/1195	480/9376	1.7163179916318	GRIA4/MT-ND2/MT-ND1/MT-ATP8/MT-ATP6/MT-ND4/WNT2/MT-CYB/BAX/MAP2K2/MT-ND5/NDUFB7/COX4I1/BAD/NRBF2/MT-ND6/UQCRH/FAS/NDUFS3/NDUFB9/CYCS/WNT5B/TOMM40/NDUFB11/SLC25A6/PSMC5/GPX7/PSMB6/COX6B1/PSMD4/HSPA5/UBE2G2/WNT5A/RPS27A/ATP5MC3/ATP5MC1/PSMD8/NDUFB5/PARK7/PSMD12/ATP5PD/PSMC3/COX6A1/COX5A/NDUFB10/NDUFA11/LRP5/COX7A1/NDUFV3/NDUFS8/PSMD13/MAP3K5/SIGMAR1/XBP1/UQCRFS1/ATF4/NDUFS6/COX8A/SLC25A5/COX5B/VDAC1/NEFM/VDAC2/HAP1/ATP5PO/ATG101/NDUFB2/BCL2/ATP5PB/NDUFB3/PSMD6/NDUFA13/DLG4/ATP5F1D/ITPR3/PINK1/UQCR11/TANK/FRAT2/SEPTIN5/CACNA1D/MAP2K7/TRAP1/COX7C/UBA52/ATP5MC2/SQSTM1/MT-ND4L/BID/DNAH14/DNAH1/CAMK2G/MAP3K10/FADD/WNT2B/NEFH/UCHL1/WNT9B/FZD10/ATP2A1/KLC2/BAK1/FZD4/AGER/SPTBN2	6.15737331883545
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	73/1195	308/9376	1.85960984622072	GRIA4/MT-ND2/MT-ND1/MT-ATP8/MT-ATP6/MT-ND4/MT-CYB/BAX/MT-ND5/NDUFB7/COX4I1/NRBF2/MT-ND6/UQCRH/NDUFS3/NDUFB9/CYCS/NDUFB11/SLC25A6/PSMC5/GPX7/PSMB6/COX6B1/PSMD4/POLR2F/ATP5MC3/ATP5MC1/PSMD8/NDUFB5/PSMD12/ATP5PD/TFAM/PSMC3/COX6A1/COX5A/NDUFB10/NDUFA11/COX7A1/NDUFV3/NDUFS8/PSMD13/MAP3K5/CLTA/UQCRFS1/NDUFS6/COX8A/SLC25A5/COX5B/VDAC1/VDAC2/HAP1/ATP5PO/ATG101/NDUFB2/ATP5PB/NDUFB3/PSMD6/NDUFA13/DLG4/ATP5F1D/CREB3/UQCR11/POLR2L/MAP2K7/COX7C/ATP5MC2/MT-ND4L/DNAH14/DNAH1/MAP3K10/BBC3/KLC2/SLC1A2	5.86256105173666
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	86/1195	388/9376	1.73906742009231	MT-ND2/MT-ND1/MT-ATP8/MT-ATP6/MT-ND4/WNT2/MT-CYB/MAP2K2/MT-ND5/NDUFB7/COX4I1/GAPDH/BAD/NRBF2/MT-ND6/UQCRH/FAS/NDUFS3/NDUFB9/CYCS/WNT5B/NDUFB11/SLC25A6/PSMC5/PSMB6/COX6B1/PSMD4/WNT5A/ATP5MC3/ATP5MC1/PSMD8/NDUFB5/PSMD12/ATP5PD/PSMC3/COX6A1/PSENEN/COX5A/NDUFB10/NDUFA11/LRP5/COX7A1/NDUFV3/NDUFS8/PSMD13/MAP3K5/XBP1/UQCRFS1/ATF4/NDUFS6/SLC39A6/COX8A/SLC25A5/SLC39A4/COX5B/VDAC1/VDAC2/IRS1/ATP5PO/ATG101/NDUFB2/NAE1/ATP5PB/NDUFB3/PSMD6/NDUFA13/ATP5F1D/ITPR3/UQCR11/FRAT2/CACNA1D/MAP2K7/COX7C/BACE2/ATP5MC2/MT-ND4L/BID/FADD/WNT2B/WNT9B/SLC39A8/FZD10/ATP2A1/KLC2/FZD4/AGER	5.68243901336844
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	59/1195	235/9376	1.96985311136829	MT-ND2/MT-ND1/MT-ATP8/MT-ATP6/MT-ND4/MT-CYB/MGLL/RPS6/MT-ND5/NDUFB7/COX4I1/MT-ND6/UQCRH/NDUFS3/FGFR1/NDUFB9/SMARCB1/NDUFB11/COX6B1/RPS6KB2/ATP5MC3/ATP5MC1/NDUFB5/SMARCD3/ATP5PD/COX6A1/COX5A/NDUFB10/NDUFAF8/NDUFA11/COX7A1/NDUFV3/NDUFS8/MAP3K5/NDUFAF3/UQCRFS1/COX14/NDUFS6/COX8A/COX5B/NDUFAF5/COA6/ATP5PO/NDUFB2/ATP5PB/NDUFB3/NDUFA13/ATP5F1D/CREB3/UQCR11/COX10/PRKAG2/NDUFAF1/COX7C/COA7/COX18/ATP5MC2/MT-ND4L/ADCY2	5.75452438263531
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	66/1195	275/9376	1.8830460251046	MT-ND2/MT-ND1/MT-ATP8/MT-ATP6/MT-ND4/MT-CYB/BAX/MT-ND5/NDUFB7/COX4I1/BAD/MT-ND6/UQCRH/NDUFS3/NDUFB9/CYCS/NDUFB11/SLC25A6/PSMC5/PSMB6/COX6B1/PSMD4/HSPA5/ATP5MC3/ATP5MC1/PSMD8/NDUFB5/PSMD12/ATP5PD/PSMC3/COX6A1/COX5A/NDUFB10/NDUFA11/COX7A1/NDUFV3/NDUFS8/PSMD13/UQCRFS1/ATF4/NDUFS6/CYBA/COX8A/SLC25A5/COX5B/VDAC1/VDAC2/ATP5PO/NOTCH1/HSPA8/NDUFB2/ATP5PB/NDUFB3/PSMD6/NCAM2/NDUFA13/ATP5F1D/ITPR3/CREB3/UQCR11/CACNA1D/COX7C/ATP5MC2/MT-ND4L/KLC2/C6	5.68030328307162
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	82/1195	368/9376	1.74829907222121	MT-ND2/MT-ND1/MT-ATP8/MT-ATP6/MT-ND4/MT-CYB/BAX/HNRNPA1/MT-ND5/NDUFB7/COX4I1/BAD/NRBF2/MT-ND6/UQCRH/NDUFS3/NDUFB9/CYCS/TOMM40/NDUFB11/PSMC5/GPX7/PSMB6/COX6B1/PSMD4/HSPA5/ATP5MC3/ATP5MC1/PSMD8/CHCHD10/NDUFB5/PSMD12/ATP5PD/PSMC3/COX6A1/COX5A/NDUFB10/NDUFA11/COX7A1/NDUFV3/NDUFS8/PSMD13/MAP3K5/SIGMAR1/XBP1/UQCRFS1/ATF4/NDUFS6/COX8A/COX5B/VDAC1/NEFM/HAP1/ATP5PO/ANXA11/ATG101/NDUFB2/BCL2/ATP5PB/NDUFB3/PSMD6/SRSF3/NDUFA13/ATP5F1D/ITPR3/PINK1/UQCR11/TANK/TPR/COX7C/ATP5MC2/SQSTM1/MT-ND4L/BID/DNAH14/DNAH1/UBQLN4/NEFH/KLC2/NRG2/SLC1A2/HNRNPA1L2	5.59694864264199
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	38/1195	157/9376	1.89903792340698	MT-CYB/BAX/NDUFB7/COX4I1/UQCRH/FAS/NDUFS3/NDUFB9/CYCS/NDUFB11/COX6B1/NDUFB5/NR1H3/COX6A1/COX5A/NDUFB10/NDUFA11/COX7A1/NDUFV3/NDUFS8/MAP3K5/XBP1/UQCRFS1/ATF4/NDUFS6/COX8A/COX5B/IRS1/NDUFB2/NDUFB3/NDUFA13/UQCR11/PRKAG2/COX7C/JUN/BID/BCL2L11/SOCS3	4.34162515505488
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	22/1195	75/9376	2.30150069735007	BAX/GSTM5/BAD/FAS/CYCS/GSTM3/XPA/GSTO1/MAP3K5/GSTM1/ERCC1/BCL2/MLH1/GSTP1/GSTM2/GSTM4/BID/FADD/BBC3/PMAIP1/BAK1/MGST2	4.32490536729143
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	11/1195	32/9376	2.69707112970711	BAX/NGFR/CYCS/BOK/BCL2/BID/FADD/BCL2L11/BBC3/PMAIP1/BAK1	3.67514953288191
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	36/1195	174/9376	1.62331553888328	ERP29/BAX/UBXN1/SSR2/HSPA5/UBE2G2/BAG1/ERLEC1/STUB1/DAD1/UFD1/PDIA6/BAG2/DNAJB12/BCAP31/MAP3K5/XBP1/ATF4/SSR3/KRTCAP2/HSPA8/BCL2/HSP90AB1/HSP90B1/NGLY1/SSR4/NFE2L2/OSTC/DNAJC5/MAP2K7/UBE2D4/UBQLN4/PREB/YOD1/BAK1/TRAM1L1	3.17181506785338
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	16/1195	59/9376	2.12773562158712	GSTM5/SRM/GPX7/GPX4/GSTM3/GSTK1/GSTO1/GSTM1/GCLC/GSTP1/GGCT/GSTM2/GGT5/GSTM4/PRDX6/MGST2	3.32094475648045
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	32/1195	154/9376	1.63034287887844	PPCS/MTHFD1L/NME1/DHRS3/AKR1A1/MOCS2/PMM1/COQ5/COQ4/VKORC1/GUSB/ADSL/GCLC/AK6/COQ2/UROS/HMBS/RFK/CAD/MTHFD2L/COX10/RDH13/NME6/ALDH3A2/GMPPA/ALDH1B1/ALAD/LIPT1/NMNAT1/PHOSPHO2/AK9/EARS2	3.01433174212283
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	20/1195	87/9376	1.80368393209253	MT-CYB/TPM1/COX4I1/TPM4/UQCRH/CACNB2/COX6B1/TPM2/COX6A1/COX5A/COX7A1/UQCRFS1/COX8A/COX5B/ASPH/UQCR11/CACNA1D/COX7C/MYL3/ATP2A1	2.87823881089523
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	28/1195	137/9376	1.60356717466329	CTSH/CTSF/BAX/MAP2K2/RIPK1/BAD/FAS/CYCS/GADD45A/PARP1/CTSZ/NTRK1/MAP3K5/ATF4/CASP10/TRADD/CTSC/BCL2/CTSD/ITPR3/DFFB/JUN/BID/FADD/BCL2L11/BBC3/PMAIP1/BAK1	2.71981777004833
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	43/1195	233/9376	1.44797888196527	CSRP1/LMOD1/TPM1/PDLIM4/SYNPO2/TPM4/FHL3/FMNL2/PDLIM2/FHL2/ZYX/TPM2/FBLN1/CAPZB/TLN1/SSPN/THBS1/SGCE/TMOD1/ITGB3/VIM/BGN/SDC4/COL4A4/NID2/ANK3/PDLIM7/VCL/ENO1/THBS2/DTNA/ITGA6/MYL3/COL4A5/COL4A1/COL27A1/MYL5/ITGA11/ITGA9/MYH11/ITGA2/LAMA1/SPTBN2	2.64641248455398
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	33/1195	170/9376	1.5230519320699	IGF2/WNT2/PLCG2/BAX/MAP2K2/GSTM5/BAD/WNT5B/SMARCB1/GADD45A/GSTM3/HGF/RPS6KB2/WNT5A/SMARCD3/LRP5/TGFB2/GSTO1/GSTM1/GSTP1/NFE2L2/GSTM2/FRAT2/GSTM4/TGFB3/TXNRD2/WNT2B/SHC3/WNT9B/FZD10/BAK1/FZD4/MGST2	2.63026908550391
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	12/1195	45/9376	2.09227336122734	ABCA8/ABCB8/ABCA6/ABCC3/ABCB6/ABCC5/ABCA9/ABCC10/DEFB1/ABCC1/ABCA13/ABCB9	2.80698375179242
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	45/1195	250/9376	1.41228451882845	CTSH/CTSF/BORCS7/GNPTG/ATP6V0C/ATP6V0D1/CTSA/CTSZ/LAMTOR4/AP1S1/CLTA/KXD1/GUSB/SNAP29/ASAH1/PPT1/CTSC/ATP6V1E2/ATP6V0A2/ACP2/CTSD/VPS16/SLC36A4/VPS39/CD63/DNASE2/CLN6/DEPTOR/ARSB/ATP6V1G2/GPR155/SLC36A1/PLEKHM1/NAGPA/ZFYVE26/TPCN2/GALNS/SLC29A3/ABCB9/AP5S1/ROGDI/CLN8/AP5B1/ATP6V1C2/FUCA1	2.52518496053198
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	26/1195	128/9376	1.59372384937238	PDE4D/ADPRM/NME1/HDDC2/NT5C/GUCY1A1/APRT/PGM2/NUDT9/ADSL/AK6/PDE4B/HPRT1/ENTPD2/GUK1/NME6/GUCY1B1/FHIT/PGM1/NT5M/ADCY2/PFAS/PDE3B/ENTPD6/PDE4C/AK9	2.58482986767957
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	23/1195	110/9376	1.64053252187143	PLCG2/EGLN3/MAP2K2/RPS6/LDHA/GAPDH/LTBR/RPS6KB2/TIMP1/TLR4/LDHB/PDHA1/BCL2/PFKFB3/ANGPT1/TEK/ENO1/PDK1/ALDOA/VEGFA/CAMK2G/TFRC/ELOB	2.58260373223139
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	22/1195	104/9376	1.65973607981976	GDPD5/CHKB/ADPRM/PEMT/PLA2G4C/PLPP4/LPIN2/LPIN3/AGPAT2/DGKH/PGS1/PLPP1/LPCAT1/DGKA/GPAM/LPCAT2/LCAT/PLA2G2A/PLD2/PNPLA6/PLD1/GPAT2	2.58563125121373
NA	NA	hsa04518	Integrin signaling	30/1195	154/9376	1.52844644894854	FLNB/ACTN1/VEGFB/LAMC3/HGF/PARVB/TLN1/THBS1/C3/ITGB3/LAMB1/COL4A4/LIMS1/VCL/FERMT1/THBS2/RAC3/VEGFA/ITGA6/VEGFC/COL4A5/COL4A1/ITGA11/LAMA4/ITGA9/ITGA2/KDR/LAMA1/VCAM1/MADCAM1	2.52705782591201
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	15/1195	63/9376	1.86810121538155	POLR2F/XPC/XPA/ERCC5/POLD2/POLE3/POLE4/ERCC4/ERCC1/RFC2/POLR2L/RFC4/RFC3/ERCC2/GTF2H4	2.64217897287635
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	9/1195	31/9376	2.27787825617492	SRPRA/SRPRB/GET3/HSPA5/SEC11C/UBL4A/OXA1L/SGTA/BAG6	2.72362347678434
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	15/1195	67/9376	1.7565727846125	LDHA/GAPDH/TPI1/PGAM1/AKR1A1/PGM2/LDHB/PDHA1/GPI/ADH1C/ALDH3A2/PGM1/ENO1/ALDH1B1/ALDOA	2.37521537339693
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	11/1195	44/9376	1.96150627615063	TDG/PARP1/POLD2/POLE3/POLE4/RFC2/NTHL1/NEIL1/NEIL2/RFC4/RFC3	2.44319140052442
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	28/1195	149/9376	1.47442082502598	GRIA4/MT-ND2/MT-ND1/MT-ND4/MGLL/MT-ND5/NDUFB7/MT-ND6/NDUFS3/NDUFB9/NDUFB11/NDUFB5/GNG4/NDUFB10/NDUFA11/NDUFV3/NDUFS8/NDUFS6/NDUFB2/NDUFB3/GNAO1/GABRE/NDUFA13/ITPR3/CACNA1D/MT-ND4L/ADCY2/GNGT1	2.23096631421974
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	36/1195	204/9376	1.38459266551809	IGF2/WNT2/PLCG2/MAP2K2/RPS6/TWIST1/FAS/FGFR1/WNT5B/HGF/RPS6KB2/WNT5A/PDCD4/TLR4/TGFB2/THBS1/TFAP4/NUDT16L1/MRAS/ITGB3/ITPR3/SDC4/ANK3/CD63/ARHGEF1/VEGFA/CAMK2G/PLAU/TIMP3/WNT2B/WNT9B/FZD10/TWIST2/FZD4/ITGA2/KDR	2.1225134591336
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	20/1195	101/9376	1.55366833754505	PLCG2/BAX/VEGFB/F3/PIM1/PLCD3/TGFB2/PRKCE/BCL2/JAK2/COL4A4/JUN/VEGFA/TGFB3/VEGFC/COL4A5/COL4A1/PRKCZ/AGER/VCAM1	2.13805961623621
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	8/1195	30/9376	2.09227336122734	PIGC/DPM2/GPAA1/MPPE1/PIGQ/PIGA/PIGZ/PIGO	2.29005269412331
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	17/1195	83/9376	1.60701719009931	PRDX5/GSTK1/PMVK/PHYH/ECH1/PEX16/MPV17L/HMGCLL1/PXMP4/PEX1/ACOX3/ACOX2/PECR/EPHX2/PAOX/AMACR/PEX12	2.12289474573062
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	14/1195	65/9376	1.68991309945285	MGLL/PLPP4/AKR1A1/LPIN2/LPIN3/AGPAT2/DGKH/PLPP1/ALDH3A2/DGKA/GPAM/ALDH1B1/LIPC/GPAT2	2.1331397101356
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	21/1195	110/9376	1.49787751996957	NBL1/RPS6KB2/TGFB2/THBS1/ID2/GDF7/SMAD6/ID3/SKIL/EMP3/LRRC32/ID1/BMP2/TGFB3/ID4/TFRC/BAMBI/E2F5/FST/LEFTY2/CDKN2B	2.00742397514924
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	17/1195	85/9376	1.5692050209205	DCTPP1/NME1/HDDC2/NT5C/APRT/ADSL/AK6/HPRT1/ENTPD2/DTYMK/GUK1/ASMTL/UPP2/NME6/NT5M/ENTPD6/AK9	2.01471374642059
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	20/1195	105/9376	1.49448097230524	TPM1/TPM4/CACNB2/TPM2/SSPN/TGFB2/SGCE/ITGB3/CACNA1D/DTNA/ITGA6/ADCY2/TGFB3/MYL3/ATP2A1/ITGA11/ITGA9/ITGA2/ADRB1/LAMA1	1.9473649008531
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	19/1195	99/9376	1.50580279785301	TPM1/TPM4/CACNB2/TPM2/SSPN/TGFB2/SGCE/ITGB3/PRKAG2/CACNA1D/DTNA/ITGA6/TGFB3/MYL3/ATP2A1/ITGA11/ITGA9/ITGA2/LAMA1	1.93357686356518
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	13/1195	63/9376	1.61902105333068	WNT2/BAX/WNT5B/GADD45A/WNT5A/GLI1/GLI2/BMP2/WNT2B/WNT9B/FZD10/BAK1/FZD4	1.88407109896651
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	5/1195	17/9376	2.30765444253015	CA3/CA13/CA8/CA1/CA4	2.0623820738109
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	4/1195	12/9376	2.61534170153417	COQ5/COQ4/VKORC1/COQ2	2.13988640666218
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	14/1195	70/9376	1.5692050209205	GSTM5/EPHX1/GSTM3/GSTK1/GSTO1/CBR1/GSTM1/GSTP1/GSTM2/CYP1B1/GSTM4/NAT1/HSD11B1L/MGST2	1.82684883566855
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	25/1195	142/9376	1.3813424479934	GSTM5/GSTM3/GSTO1/MAP3K5/CYBA/GSTM1/BCL2/HSP90AB1/ITGB3/HSP90B1/GSTP1/NFE2L2/SDC4/GSTM2/GSTM4/MAP2K7/TXN/JUN/RAC3/SQSTM1/VEGFA/PRKCZ/MGST2/KDR/VCAM1	1.74997071795251
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	7/1195	28/9376	1.96150627615063	ATP6V0C/ATP6V0D1/ATP6V1E2/ATP6V0A2/SLC12A7/ATP6V1G2/ATP6V1C2	1.94732384456428
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	8/1195	34/9376	1.84612355402412	POLR2F/POLR1E/POLR3D/POLR3GL/POLR1B/POLR3H/POLR2L/POLR3G	1.88894671207915
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	8/1195	34/9376	1.84612355402412	NFIL3/NPAS2/NR1D1/PER3/PRKAG2/BHLHE41/RORA/BHLHE40	1.88894671207915
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	6/1195	23/9376	2.04678915772239	POLD2/SSBP1/MLH1/RFC2/RFC4/RFC3	1.92094115468131
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	12/1195	59/9376	1.59580171619034	DCTPP1/NME1/HDDC2/NT5C/DTYMK/CAD/ASMTL/UPP2/NME6/NT5M/ENTPD6/AK9	1.75451102848001
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	10/1195	47/9376	1.66936704353245	LDHA/AKR1A1/GRHPR/LDHB/PDHA1/ADH1C/HAGH/ALDH3A2/ACYP2/ALDH1B1	1.7581750100394
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	9/1195	41/9376	1.72229819369323	PGAM1/GRHPR/GCSH/DMGDH/GAMT/SRR/PHGDH/BHMT/AMT	1.77140428345741
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	9/1195	41/9376	1.72229819369323	RAD51C/POLD2/SSBP1/RAD52/TOPBP1/XRCC3/PALB2/RAD51D/XRCC2	1.77140428345741
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	6/1195	24/9376	1.96150627615063	EXT2/B3GAT3/NDST1/B3GALT6/XYLT2/HS6ST2	1.80248595632561
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	17/1195	93/9376	1.4342196427768	BAX/CYCS/GADD45A/LAMC3/BCL2/LAMB1/COL4A4/TRAF5/FHIT/ITGA6/COL4A5/COL4A1/LAMA4/BAK1/ITGA2/LAMA1/CDKN2B	1.60832258012467
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	15/1195	80/9376	1.47112970711297	PLCG2/BAX/MAP2K2/RPS6/BAD/GAS6/HGF/RPS6KB2/BCL2/JAK2/VEGFA/BCL2L11/SHC3/NRG2/KDR	1.6173492819307
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	8/1195	36/9376	1.74356113435611	RNASEH2C/POLD2/POLE3/SSBP1/POLE4/RFC2/RFC4/RFC3	1.70828720508772
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	16/1195	87/9376	1.44294714567402	BAX/MAP2K2/BAD/CYCS/GADD45A/RPS6KB2/TGFB2/BCL2/MLH1/JUN/RAC3/TGFB3/BCL2L11/BBC3/PMAIP1/BAK1	1.5863296688473
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	33/1195	203/9376	1.27546220912258	FLNB/ACTN1/BAD/VEGFB/LAMC3/HGF/ZYX/PARVB/TLN1/THBS1/BCL2/ITGB3/LAMB1/COL4A4/PIP5K1A/VCL/THBS2/JUN/RAC3/MYLK/VEGFA/ITGA6/VEGFC/COL4A5/SHC3/COL4A1/MYL5/ITGA11/LAMA4/ITGA9/ITGA2/KDR/LAMA1	1.51642432656341
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	23/1195	134/9376	1.34670580153625	MAP2K2/ACTA2/RAMP1/PLA2G4C/KCNMB3/GUCY1A1/MYL6B/PPP1R14A/EDN3/PRKCE/ARHGEF11/KCNMA1/ITPR3/AVPR1A/GUCY1B1/ARHGEF1/CACNA1D/MYLK/ADCY2/PLA2G2A/ADM/MYH11/ADRA1D	1.54488771798615
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	5/1195	19/9376	2.06474344857961	DLST/GCSH/PDHA1/LIPT1/AMT	1.77549664817691
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	8/1195	37/9376	1.6964378604546	PGM2/PMM1/NANS/GPI/GALK1/GMDS/PGM1/GMPPA	1.6221814897534
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	7/1195	31/9376	1.77168308813605	PGP/HYI/GRHPR/GCSH/MCEE/PCCB/AMT	1.64473741166552
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	33/1195	205/9376	1.26301867537504	PLCG2/BAX/NFKBIB/RIPK1/FAS/CYCS/GADD45A/PSMC5/PSMD4/PSMD8/PSMD12/PSMC3/PSMD13/TRADD/IRF3/SAP30/BCL2/IFNAR2/PSMD6/VIM/RELB/TAPBPL/IRAK1/TRAF5/MAP2K7/JUN/BID/TYK2/NFKB2/FADD/BCL2L11/NCOR2/BAK1	1.45519624212313
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	15/1195	82/9376	1.43524849474436	CES1/GSTM5/NME1/GSTM3/GSTO1/GUSB/GSTM1/GSTP1/HPRT1/UPP2/NME6/GSTM2/GSTM4/NAT1/MGST2	1.51289666130001
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	24/1195	144/9376	1.30767085076708	KCND3/NOP56/NRBF2/CYCS/SLC25A6/PSMC5/PSMB6/PSMD4/PSMD8/PSMD12/PSMC3/PSMD13/MAP3K5/XBP1/SLC25A5/VDAC1/VDAC2/ATG101/PSMD6/ITPR3/TWNK/RORA/ATP2A1/SPTBN2	1.42195579369058
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	5/1195	20/9376	1.96150627615063	NANS/GMDS/GMPPA/CYB5R4/NPL	1.64508525274832
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	7/1195	32/9376	1.7163179916318	LDHA/SUCLA2/LDHB/MCEE/HADHA/PCCB/ACOX3	1.55124654839592
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	18/1195	105/9376	1.34503287507472	PLCG2/RIPK1/LTBR/GADD45A/PARP1/TLR4/CXCL12/TRADD/BCL2/RELB/IRAK1/TRAF5/PLAU/NFKB2/EDA2R/TICAM1/TNFSF13B/VCAM1	1.35880842376715
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	19/1195	112/9376	1.33102211595935	NFKBIB/BAD/CYCS/LAMC3/TLR4/TGFB2/LDLR/HSPA8/BCL2/LAMB1/GNAO1/ALOX5/JAK2/IRAK1/TYK2/ITGA6/TGFB3/LAMA4/LAMA1	1.34689314660479
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	39/1195	253/9376	1.20946632047232	PLCG2/BAX/NFKBIB/RIPK1/ACTN1/CYCS/RPS6KB2/ARPC5/RPS27A/TLR4/ARPC5L/PLCD3/UBE2V2/TLN1/CGAS/CASP4/VDAC1/TRADD/SHARPIN/TNIP1/IRF3/U2AF1/PRKCE/BCL2/C3/UBE2V1/ITPR3/CYTH2/CBX3/TRAF5/VCL/BNIP3/UBA52/NOD1/JUN/SQSTM1/UBE2D4/MYL5/TIFA	1.29083883149916
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	10/1195	52/9376	1.50885098165433	PLA2G4C/LDLR/SCARB1/CYP11A1/ALOX5/CYP1B1/ADCY2/HSD17B7/HSD17B1/ACOT2	1.40623385902011
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	50/1195	333/9376	1.17808184753791	WNT2/BAX/MAP2K2/BAD/FAS/WNT5B/LAMC3/ATP6V0C/ATP6V0D1/RPS6KB2/WNT5A/BCAP31/THBS1/TADA3/TRADD/IRF3/NOTCH1/ATP6V1E2/IFNAR2/ITGB3/LAMB1/NFX1/ATP6V0A2/ATR/CREB3/COL4A4/MAGI1/THBS2/TYK2/ATP6V1G2/VEGFA/ITGA6/FADD/WNT2B/COL4A5/COL4A1/PRKCZ/WNT9B/FZD10/HES6/ITGA11/LAMA4/ITGA9/BAK1/NOTCH4/FZD4/TICAM1/ITGA2/ATP6V1C2/LAMA1	1.26459627585689
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	14/1195	79/9376	1.39043482866374	GSTM5/EPHX1/GSTM3/GSTK1/GSTO1/CBR1/GSTM1/GSTP1/ADH1C/GSTM2/CYP1B1/GSTM4/HSD11B1L/MGST2	1.33185540203429
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	14/1195	79/9376	1.39043482866374	VAMP2/ATP6V0C/ATP6V0D1/NSF/DNM3/CLTA/ATP6V1E2/DNM1/ATP6V0A2/DNM2/ATP6V1G2/SLC1A1/SLC1A2/ATP6V1C2	1.33185540203429
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	10/1195	54/9376	1.45296761196343	LDHA/SRM/BHMT2/CISD1/CDO1/LDHB/GCLC/TST/PHGDH/BHMT	1.27578025205835
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	15/1195	88/9376	1.33739064282997	C2/CFI/F3/CD59/F2RL2/CD55/BDKRB2/CD46/C3/CFD/PLAU/CLU/C6/C5AR1/SERPINF2	1.21528926296986
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	13/1195	75/9376	1.35997768479777	BAX/FAS/CYCS/GADD45A/THBS1/CHEK2/BCL2/ATR/GORAB/BID/ZNF385A/BBC3/PMAIP1	1.19621097726408
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	26/1195	166/9376	1.22889549831124	MAP2K2/BAD/SLC25A6/EDNRB/KCNMB3/ADRA2C/GUCY1A1/ATF4/SLC25A5/VDAC1/VDAC2/IRS1/BDKRB2/PRKCE/KCNMA1/ITPR3/CREB3/GUCY1B1/CACNA1D/MYLK/ADCY2/ATP2A1/MEF2B/PDE3B/ADRA1D/ADRB1	1.13717649633124
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	15/1195	89/9376	1.32236378167458	LAMC3/THBS1/ITGB3/LAMB1/SDC4/COL4A4/THBS2/ITGA6/COL4A5/COL4A1/ITGA11/LAMA4/ITGA9/ITGA2/LAMA1	1.16780388828619
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	4/1195	17/9376	1.84612355402412	CYP39A1/ACOX2/SLC27A5/AMACR	1.33447338478206
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	26/1195	168/9376	1.21426578999801	BAX/RIPK1/FAS/SLC25A6/PARP1/PLA2G4C/TLR4/SLC25A5/VDAC1/TRADD/SHARPIN/VDAC2/BCL2/HSP90AB1/IFNAR2/JAK2/PPIA/TRAF5/SQSTM1/BID/TYK2/CAMK2G/FADD/CHMP6/TICAM1/SPATA2L	1.07100430500139
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	10/1195	56/9376	1.40107591153616	ALG8/SRD5A3/ALG12/DAD1/DPM2/DPM3/KRTCAP2/OSTC/MAN2A1/MAN2A2	1.1504798881295
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	13/1195	78/9376	1.30767085076708	C1D/EXOSC5/MPHOSPH6/BTG2/EXOSC8/BTG1/EXOSC6/LSM4/LSM3/HSPD1/DCP1B/EXOSC2/ENO1	1.04281021657789
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	3/1195	12/9376	1.96150627615063	NGFR/CD46/NCAM2	1.27373311064834
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	8/1195	44/9376	1.42655001901864	ALG12/DAD1/KRTCAP2/HEXD/OSTC/MAN2A1/B4GALNT3/MAN2A2	1.08386535190604
NA	NA	hsa04981	Folate transport and metabolism	6/1195	31/9376	1.51858550411661	BHMT2/ABCC3/ABCC5/ABCC1/BHMT/SLC19A1	1.10529437910611
Human Diseases	Infectious disease: viral	hsa05162	Measles	21/1195	136/9376	1.21151858232833	BAX/NFKBIB/RACK1/BAD/EIF3H/FAS/CYCS/TLR4/TRADD/IRF3/HSPA8/BCL2/IFNAR2/CD46/IRAK1/JUN/BID/TYK2/FADD/BBC3/BAK1	0.949616801834774
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	7/1195	38/9376	1.44532041400573	GNPDA1/PGM2/PMM1/GPI/GALK1/PGM1/GMPPA	1.05124480389155
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	28/1195	187/9376	1.17480589801535	NFKBIB/RIPK1/TLR4/GABARAPL2/CYBA/CASP4/VDAC1/SHARPIN/VDAC2/NAMPT/IRF3/BCL2/HSP90AB1/IFNAR2/ITPR3/CARD6/TANK/TRAF5/TXN/NOD1/JUN/CARD16/TYK2/RNASEL/FADD/NLRX1/TICAM1/CARD9	0.92280333166587
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	18/1195	115/9376	1.22807349463344	PDE4D/PTH1R/FGFR1/WNK2/NACA/LRP5/ATF4/BCL2/PDE4B/ARHGEF11/ITPR3/CREB3/ARHGEF1/ADCY2/RUNX2/PLD2/PLD1/PDE4C	0.940505175206389
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	22/1195	144/9376	1.19869827986983	RIPK1/FAS/C2/TLR4/MAP3K5/TRA2B/TRADD/LPIN2/LPIN3/IRF3/ACADVL/C3/ADH1C/PRKAG2/IRAK1/ALDH3A2/MAP2K7/ACOX3/ALDH1B1/FADD/C5AR1/TICAM1	0.918319592359252
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	9/1195	52/9376	1.3579658834889	LRPAP1/PLTP/LDLR/VDAC1/VDAC2/SCARB1/ANGPTL4/LCAT/LIPC	0.989255722961523
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	37/1195	254/9376	1.14292491681218	FGF10/PLCG2/FGFR1/VEGFB/SLC25A6/EDNRB/HGF/GNA14/PLCD3/NTRK1/SLC25A5/VDAC1/VDAC2/BDKRB2/ASPH/CAMK1D/ITPR3/AVPR1A/HTR2B/PHKA2/CACNA1D/PTGER3/MYLK/HRH2/CACNA1H/VEGFA/CAMK2G/ADCY2/GNAL/VEGFC/ITPKA/TPCN2/ATP2A1/PHKA1/ADRA1D/ADRB1/KDR	0.882563915632099
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	7/1195	39/9376	1.40826091621071	MTHFD1L/BHMT2/GCSH/DMGDH/MTHFD2L/BHMT/AMT	0.976411362117138
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	15/1195	95/9376	1.23884606914776	ATP6V0C/ATP6V0D1/TLR4/TGFB2/CXCL12/ATP6V1E2/ATP6V0A2/ANGPT1/TEK/JUN/ATP6V1G2/VEGFA/TGFB3/ATP6V1C2/TNFSF13B	0.894229327414446
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	8/1195	46/9376	1.36452610514826	PSMC5/PSMB6/PSMD4/PSMD8/PSMD12/PSMC3/PSMD13/PSMD6	0.947181318545379
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	5/1195	26/9376	1.50885098165433	SCARB1/ABCC1/LRAT/SLC19A1/MMACHC	0.99297400605098
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	6/1195	33/9376	1.42655001901864	VAMP2/VTI1B/SNAP29/BET1L/STX4/STX8	0.938102202653831
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	9/1195	54/9376	1.30767085076708	RAD51C/ERCC4/CENPX/ERCC1/MLH1/ATR/PALB2/EME2/FAAP24	0.866552895120302
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	31/1195	214/9376	1.13657373010597	PLCG2/BAX/MAP2K2/RIPK1/BAD/FAS/CYCS/RPS6KB2/TLR4/AP1S1/GNG4/CGAS/TRADD/IRF3/BCL2/GNAO1/ATR/ITPR3/TAPBPL/LIMK2/IRAK1/TRAF5/MAP2K7/JUN/RAC3/BID/CD4/FADD/ELOB/BAK1/GNGT1	0.772405412745552
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	13/1195	83/9376	1.22889549831124	NFKBIB/RIPK1/POLR2F/CGAS/GSDME/IRF3/POLR3D/POLR3GL/POLR3H/POLR2L/DNASE2/FADD/POLR3G	0.800506243664727
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	16/1195	105/9376	1.19558477784419	TOMM40/FKBP8/RPS27A/PHB2/FIS1/GABARAPL2/ATF4/MRAS/CITED2/PINK1/SAMM50/BNIP3/UBA52/JUN/SQSTM1/NLRX1	0.770251946681212
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	15/1195	98/9376	1.20092220988814	PLCG2/RPS6KB2/PLA2G4C/ARPC5/ARPC5L/BIN1/PRKCE/GSN/DNM2/PLPP1/ASAP1/LIMK2/PIP5K1A/PLD2/PLD1	0.764152774800441
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	18/1195	120/9376	1.17690376569038	PLCG2/BAX/MAP2K2/NFKBIB/BAD/NGFR/NTRK1/MAP3K5/ATF4/IRS1/BCL2/IRAK1/ZNF274/MAP2K7/JUN/CAMK2G/SHC3/SH2B2	0.745388043736054
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	31/1195	216/9376	1.12604989927166	BAX/BAD/FAS/CYCS/HSPA5/TLR4/MAP3K5/XBP1/LDLR/ATF4/CYBA/IRF3/HSPA8/BCL2/HSP90AB1/HSPD1/HSPA4/HSP90B1/NFE2L2/TANK/JAK2/IRAK1/MIB2/ARHGEF1/MAP2K7/JUN/BID/CAMK2G/TICAM1/AGER/VCAM1	0.71628859498475
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	32/1195	224/9376	1.12086072922893	BAX/MAP2K2/LTBR/SLC25A6/ANAPC13/FDPS/TLN1/TGFB2/ATF4/SLC25A5/VDAC1/ETS2/VDAC2/CHEK2/RAN/ANAPC11/MAD1L1/ATR/RELB/ANAPC1/CREB3/VAC14/NRP1/ANAPC7/ANAPC15/JUN/CD4/ADCY2/TGFB3/NFKB2/ANAPC2/CDKN2B	0.699709238754833
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	22/1195	150/9376	1.15075034867504	FGF10/WNT2/BAX/MAP2K2/WNT5B/GADD45A/HGF/RPS6KB2/WNT5A/LRP5/TGFB2/BCL2/MLH1/FRAT2/TGFB3/WNT2B/SHC3/WNT9B/FZD10/BAK1/FZD4/CDKN2B	0.711317714176299
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	12/1195	77/9376	1.22275715915883	BAX/BAD/GADD45A/RPS6KB2/TGFB2/RALBP1/RAC3/VEGFA/TGFB3/PLD2/PLD1/BAK1	0.750110602194143
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	4/1195	21/9376	1.49448097230524	B3GAT3/CSGALNACT2/B3GALT6/XYLT2	0.866969322822872
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	4/1195	21/9376	1.49448097230524	CSAD/PPCS/ALDH3A2/ALDH1B1	0.866969322822872
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	25/1195	173/9376	1.13381865673447	BAX/MAP2K2/NFKBIB/FAS/CYCS/SLC25A6/PABPN1/TLR4/FDPS/RAB11B/SLC25A5/VDAC1/TRADD/IRF3/IFNAR2/JAK2/BCL2L2-PABPN1/BID/TYK2/RNASEL/FADD/SOCS3/NLRX1/BAK1/TICAM1	0.678955641406004
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	9/1195	56/9376	1.26096832038255	BOC/GLI1/MGRN1/GAS1/BCL2/GLI2/EVC/EVC2/CDON	0.748583486076515
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	5/1195	28/9376	1.40107591153616	HSD17B12/PPT1/THEM4/HADHA/ACOT2	0.81229286317458
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	6/1195	35/9376	1.34503287507472	TPI1/PMM1/PFKFB3/GMDS/GMPPA/ALDOA	0.781563389531799
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	7/1195	42/9376	1.30767085076708	SAT2/GPX4/VDAC2/GCLC/TFRC/SLC39A8/SLC7A11	0.763736407240757
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	19/1195	130/9376	1.14672674605729	MAP2K2/ACTA2/VEGFB/EDNRB/GNG4/ATF4/GNAO1/CREB3/COL4A4/MAP2K7/JUN/VEGFA/ADCY2/VEGFC/COL4A5/SHC3/COL4A1/PRKCZ/GNGT1	0.643828818749503
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	8/1195	50/9376	1.2553640167364	GYPC/HGF/TLR4/TGFB2/THBS1/THBS2/TGFB3/VCAM1	0.691931961819505
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	15/1195	101/9376	1.16525125315879	WNT2/MAP2K2/WNT5B/EDNRB/WNT5A/KITLG/GNAO1/CREB3/CAMK2G/ADCY2/WNT2B/POMC/WNT9B/FZD10/FZD4	0.638138406970913
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	20/1195	138/9376	1.13710508762355	MAP2K2/RPS6/SOCS2/PRKAR2B/BAD/RPS6KB2/SORBS1/PRKAR1B/FLOT1/IRS1/PPP1R3B/PRKAG2/PHKA2/PPP1R3F/SOCS3/SHC3/PRKCZ/PHKA1/SH2B2/PDE3B	0.620112562301613
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	4/1195	22/9376	1.42655001901864	HNMT/CARNMT1/ALDH3A2/ALDH1B1	0.765506738133347
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	17/1195	116/9376	1.14984850670899	TKT/PGP/GAPDH/TPI1/PGAM1/SUCLA2/DLST/GCSH/PDHA1/MCEE/GPI/PCCB/ACOX3/ENO1/ALDOA/PHGDH/AMT	0.620643648356723
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	10/1195	65/9376	1.20708078532346	LDLR/ATF4/SCARB1/CYP11A1/ITPR3/CREB3/CACNA1D/CACNA1H/ADCY2/POMC	0.640272299119803
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	24/1195	169/9376	1.11422841722166	MAP2K2/BAD/NRBF2/IGBP1/GORASP1/RPS6KB2/RPS27A/GABARAPL2/SNAP29/IRS1/DAPK3/MRAS/ATG101/BCL2/CTSD/VPS16/VPS39/TANK/BNIP3/MTMR14/UBA52/DEPTOR/SQSTM1/PLEKHM1	0.572696902759497
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	8/1195	51/9376	1.23074903601608	PLA2G7/PLA2G4C/PLPP1/LPCAT1/LPCAT2/PLA2G2A/PLD2/PLD1	0.631490698025086
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	8/1195	51/9376	1.23074903601608	PLCG2/ATP6V0C/ATP6V0D1/ATP6V1E2/ATP6V0A2/KDELR3/ATP6V1G2/ATP6V1C2	0.631490698025086
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	11/1195	73/9376	1.18227775548805	SMARCB1/PSIP1/FEZ1/ELL2/SUPT4H1/PIN1/RAN/PPIA/CD4/CHMP6/BICD1	0.597516615218265
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	18/1195	125/9376	1.12982761506276	BAX/MAP2K2/DEGS1/MAP3K5/TRADD/ASAH1/BDKRB2/PRKCE/BCL2/CTSD/ABCC1/CERS4/RAC3/BID/SMPD2/PRKCZ/PLD2/PLD1	0.558462658883894
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	22/1195	155/9376	1.11362936968552	WNT2/MAP2K2/WNT5B/WNT5A/LDLR/AIP/ATF4/SCARB1/CYP11A1/ITPR3/CREB3/RBBP5/CACNA1D/CACNA1H/CAMK2G/ADCY2/WNT2B/POMC/WNT9B/FZD10/FZD4/CDKN2B	0.545172361268319
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	6/1195	37/9376	1.27232839534095	FAHD1/GSTZ1/ADH1C/TH/LRTOMT/TPO	0.634322323843755
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	6/1195	37/9376	1.27232839534095	BAX/MAP2K2/GADD45A/NTRK1/TPR/BAK1	0.634322323843755
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	15/1195	103/9376	1.14262501523338	ACTN1/LAMC3/GNA14/SERPINB6/TLR4/TGFB2/LAMB1/COL4A4/VCL/TGFB3/GNAL/COL4A5/COL4A1/LAMA4/LAMA1	0.556250713151305
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	21/1195	148/9376	1.11328734592333	FGF10/WNT2/BAX/MAP2K2/FGFR1/WNT5B/GADD45A/RPS6KB2/WNT5A/LRP5/NOTCH1/FRAT2/JUN/NFKB2/WNT2B/SHC3/WNT9B/FZD10/BAK1/NOTCH4/FZD4	0.530914836112652
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	4/1195	23/9376	1.36452610514826	PMVK/FDPS/ZMPSTE24/PDSS1	0.668934323754895
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	22/1195	156/9376	1.10649071987984	BAX/MAP2K2/RIPK1/BAD/FAS/CYCS/NR1H3/LDLR/TRADD/IRF3/SCARB1/IFNAR2/EIF3E/CLDN10/BID/TYK2/RNASEL/FADD/SOCS3/CLDN4/BAK1/TICAM1	0.51259574407367
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	21/1195	149/9376	1.10581561876948	PLCG2/MAP2K2/LPAR1/PLA2G4C/DNM3/GRM7/MRAS/DNM1/AGPAT2/KITLG/DGKH/AVPR1A/DNM2/PLPP1/PIP5K1A/CYTH2/DGKA/ADCY2/SHC3/PLD2/PLD1	0.497598479114204
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	49/1195	362/9376	1.0620310224462	FGF10/IGF2/MAP2K2/RPS6/LPAR1/BAD/NGFR/FGFR1/VEGFB/LAMC3/HGF/RPS6KB2/TLR4/OSMR/GNG4/NTRK1/THBS1/ATF4/CDC37/IRS1/THEM4/BCL2/HSP90AB1/IFNAR2/ITGB3/LAMB1/HSP90B1/KITLG/ANGPT1/CREB3/JAK2/COL4A4/MAGI1/TEK/THBS2/VEGFA/ITGA6/VEGFC/BCL2L11/COL4A5/COL4A1/ITGA11/CSF3R/LAMA4/ITGA9/ITGA2/KDR/LAMA1/GNGT1	0.460013781158237
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	25/1195	180/9376	1.08972570897257	BAX/BAD/FAS/CYCS/CGAS/TRADD/IRF3/BCL2/IFNAR2/C3/ITGB3/SRSF3/TAPBPL/JAK2/IRAK1/EIF2B5/TRAF5/BID/TYK2/RNASEL/FADD/SOCS3/BAK1/TICAM1/CARD9	0.464536736302381
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	6/1195	38/9376	1.23884606914776	NT5C/NAMPT/BST1/NMRK1/NT5M/NMNAT1	0.563831527198482
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	5/1195	31/9376	1.26548792009718	TKT/PGM2/GPI/PGM1/ALDOA	0.565851346546695
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	5/1195	31/9376	1.26548792009718	CSAD/HADHA/ALDH3A2/ACOX3/ALDH1B1	0.565851346546695
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	22/1195	158/9376	1.09248450823579	WNT2/MAP2K2/RPS6/WNT5B/RPS6KB2/WNT5A/LAMTOR4/LRP5/IRS1/LPIN2/LPIN3/TBC1D7/ATP6V1E2/MAPKAP1/DEPTOR/ATP6V1G2/CASTOR2/WNT2B/WNT9B/FZD10/FZD4/ATP6V1C2	0.448069701347826
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	7/1195	46/9376	1.19396034200473	GUSB/UROS/HMBS/COX10/HCCS/ALAD/EARS2	0.503984789815892
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	3/1195	17/9376	1.38459266551809	CSAD/CDO1/GGT5	0.606564695753229
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	3/1195	17/9376	1.38459266551809	NRP2/TFRC/MYH11	0.606564695753229
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	14/1195	99/9376	1.10953890368116	MAP2K2/CHKB/RPS6KB2/PLA2G4C/SLC22A3/DGKH/PLPP1/PIP5K1A/DGKA/SLC22A5/JUN/RAC3/PLD2/PLD1	0.418744005998448
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	32/1195	238/9376	1.05492774515664	FGF10/IGF2/PLCG2/MAP2K2/BAD/RASSF1/NGFR/FGFR1/VEGFB/HGF/PLA2G4C/GNG4/NTRK1/ETS2/MRAS/KITLG/ANGPT1/RGL1/AFDN/RALBP1/TEK/RAC3/VEGFA/VEGFC/SHC3/PLA2G2A/KSR1/RIN1/PLD2/PLD1/KDR/GNGT1	0.328035667462117
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	3/1195	18/9376	1.30767085076708	MAN2C1/HEXD/FUCA1	0.499341290210044
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	3/1195	18/9376	1.30767085076708	CD320/ZNF143/MMACHC	0.499341290210044
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	16/1195	116/9376	1.08221035925552	GRIA4/PLA2G4C/GRM7/GNG4/HOMER1/SHANK2/GNAO1/DLG4/ITPR3/CACNA1D/ADCY2/SLC1A1/PLD2/PLD1/SLC1A2/GNGT1	0.340499471243655
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	11/1195	78/9376	1.10649071987984	ARPC5/DNM3/ARPC5L/CLTA/DNM1/DNM2/SEPTIN1/VCL/MAD2L2/ARHGEF26/SHC3	0.360936404552344
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	9/1195	63/9376	1.12086072922893	KMT5A/DLST/SETDB2/HADHA/ALDH3A2/ALDH1B1/HYKK/DOT1L/SMYD3	0.367855351146842
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	9/1195	63/9376	1.12086072922893	GPX4/PLA2G4C/PTGES2/CBR1/ALOX5/GGT5/PTGIS/EPHX2/PLA2G2A	0.367855351146842
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	7/1195	48/9376	1.1442119944212	ACSF3/MCEE/HMGCLL1/HADHA/ALDH3A2/PCCB/ALDH1B1	0.38281956689414
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	12/1195	86/9376	1.09479420064221	CACNB2/SSPN/SGCE/ITGB3/CACNA1D/DTNA/ITGA6/ATP2A1/ITGA11/ITGA9/ITGA2/LAMA1	0.337512243535761
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	10/1195	71/9376	1.10507395839472	PLCG2/ATP6V0C/ATP6V0D1/JAM3/ATP6V1E2/ATP6V0A2/NOD1/JUN/ATP6V1G2/ATP6V1C2	0.339650668453217
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	8/1195	56/9376	1.12086072922893	CYCS/EEF1G/TLR4/HSPA8/HSPD1/C3/BNIP3/NFKB2	0.346687084023526
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	3/1195	19/9376	1.23884606914776	GUSB/ARSB/GALNS	0.39828410850314
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	21/1195	158/9376	1.0428261214978	CDC25B/GADD45A/ANAPC13/TGFB2/CHEK2/FBXO5/ANAPC11/MAD1L1/ATR/ANAPC1/CDC7/ANAPC7/MAD2L2/ANAPC15/TGFB3/ANAPC2/MAD2L1BP/E2F5/DBF4B/FZR1/CDKN2B	0.207484343437093
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	10/1195	73/9376	1.07479795953459	GSTM5/GSTM3/GSTK1/GSTO1/GSTM1/GSTP1/ADH1C/GSTM2/GSTM4/MGST2	0.24519186933521
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	4/1195	27/9376	1.16237408957074	HMGCLL1/HADHA/ALDH5A1/ACSM3	0.322910692286568
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	13/1195	97/9376	1.05152913773023	GRIA4/GUCY1A1/GNG4/GNAO1/PER3/ITPR3/GUCY1B1/CACNA1D/CACNA1H/CAMK2G/ADCY2/NOS1AP/GNGT1	0.194964055200204
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	39/1195	300/9376	1.01998326359833	FGF10/IGF2/MAP2K2/CDC25B/NGFR/FAS/FGFR1/VEGFB/GADD45A/CACNB2/HGF/PLA2G4C/NTRK1/TGFB2/MAP3K5/ATF4/TRADD/HSPA8/MRAS/KITLG/ECSIT/ANGPT1/RELB/TEK/IRAK1/CACNA1D/MAP2K7/MAP3K8/JUN/RAC3/CACNA1H/VEGFA/MAP3K10/TGFB3/NFKB2/VEGFC/IL1RAP/MAPK8IP1/KDR	0.134445476727621
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	6/1195	43/9376	1.09479420064221	ACADVL/ADH1C/HADHA/ALDH3A2/ACOX3/ALDH1B1	0.238106777885799
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	13/1195	98/9376	1.04079924856972	PLCG2/PLCD3/PIP4P1/IP6K3/DGKH/INPP1/ITPR3/ITPK1/PIP5K1A/DGKA/MTMR14/MTMR8/ITPKA	0.155168803994752
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	13/1195	98/9376	1.04079924856972	LDLR/ATF4/SCARB1/PRKCE/CAMK1D/CYP11A1/ITPR3/CREB3/CACNA1D/CACNA1H/CAMK2G/ADCY2/POMC	0.155168803994752
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	4/1195	28/9376	1.12086072922893	MOCS2/CBR1/QDPR/TH	0.244777372479732
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	26/1195	200/9376	1.01998326359833	BAX/NFKBIB/LPAR1/RIPK1/GAPDH/FAS/CYCS/NCL/ARPC5/MYO1E/TLR4/ARPC5L/CASP4/TRADD/RPS3/ABCF2/ARHGEF11/IRAK1/CYTH2/CLDN10/ARHGEF1/JUN/FADD/CLDN4/BAK1/MYH11	0.109174473721432
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	5/1195	36/9376	1.08972570897257	PGM2/GPI/PGM1/MGAM/GBE1	0.206139446406108
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	5/1195	36/9376	1.08972570897257	ST6GALNAC4/GALNT8/GALNT10/ST6GALNAC2/C1GALT1C1L	0.206139446406108
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	6/1195	44/9376	1.06991251426398	VAMP2/NSF/AQP3/RAB11B/STX4/CREB3	0.177647986160451
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	8/1195	60/9376	1.04613668061367	PLCG2/MAP2K2/BAD/PLA2G4C/RAC3/SH2D2A/VEGFA/KDR	0.137016738334921
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	21/1195	163/9376	1.01083759016351	BAX/MAP2K2/BAD/FAS/CYCS/TLR4/TGFB2/ATF4/CASP10/IRF3/BCL2/CREB3/JAK2/IRAK1/MAP2K7/JUN/BID/TYK2/TGFB3/FADD/TICAM1	0.0533448360555346
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	4/1195	29/9376	1.08221035925552	RASSF1/FRMD6/RASSF4/TEAD4	0.169455558105734
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	7/1195	53/9376	1.03626746664561	PTH1R/DNM3/CLTA/BDKRB2/DNM1/DNM2/KLK1	0.101191424004758
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	25/1195	196/9376	1.00076850824012	PLCG2/BAX/MAP2K2/FAS/CYCS/RPS27A/CLEC2B/GNG4/TRADD/IRF3/IFNAR2/C3/ITPR3/JAK2/MAP2K7/UBA52/JUN/BID/TYK2/VEGFA/FADD/BAK1/MICB/TICAM1/GNGT1	0.00415548403426121
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	27/1195	212/9376	0.999257914265414	FGF10/MAP2K2/LPAR1/NGFR/FGFR1/VEGFB/HGF/TLN1/THBS1/MRAS/P2RY1/ITGB3/KITLG/GNAO1/ANGPT1/AFDN/MAGI1/TEK/SIPA1L3/RAC3/RGS14/ID1/VEGFA/ADCY2/VEGFC/PRKCZ/KDR	-0.00417682103882362
NA	NA	hsa04517	IgSF CAM signaling	38/1195	299/9376	0.99715369222373	PLCG2/MAP2K2/EPB41L3/ACTN1/FGFR1/NRP2/ARPC5/KCNQ3/PPFIA2/ARPC5L/SORBS1/NLGN2/CLMP/NLGN4X/MYL6B/JAM3/CNTN1/PLXNA2/ITGB3/NCAM2/NRP1/AFDN/MAGI1/ANK3/VCL/UNC5B/MYLK/PLXNA1/NTN1/PPFIA3/LRRC4B/IL1RAP/PVR/GRIP1/MYH11/KDR/SPTBN2/MPP3	-0.0191166892366658
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	20/1195	157/9376	0.999493643898409	WNT2/RASSF1/WNT5B/WNT5A/FRMD6/TGFB2/ID2/GDF7/DLG4/GLI2/ID1/BMP2/TGFB3/WNT2B/PRKCZ/BBC3/WNT9B/FZD10/TEAD4/FZD4	-0.00244528993810667
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	23/1195	181/9376	0.99700871494949	BAX/BAD/CYCS/ATP6V0C/ATP6V0D1/TLR4/TGFB2/RFXANK/CASP10/TRADD/BCL2/HSPD1/C3/ATP6V0A2/CTSD/JAK2/IRAK1/BID/CAMK2G/TGFB3/FADD/KSR1/CARD9	-0.0155305778766153
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	9/1195	70/9376	1.00877465630604	EGLN3/MAP2K2/BAD/HGF/TGFB2/JUN/VEGFA/TGFB3/ELOB	0.0281620331285067
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	4/1195	30/9376	1.04613668061367	ABCC3/ABCC5/ABCC1/SLC19A1	0.0967298420777351
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	10/1195	78/9376	1.00590065443622	PLCG2/TPI1/PLCD3/IP6K3/INPP1/ITPK1/PIP5K1A/MTMR14/MTMR8/ITPKA	0.0199994985395717
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	18/1195	142/9376	0.994566562555248	UBE2G2/RPS27A/UBE2Q1/STUB1/MGRN1/ANAPC13/UBE2A/UBE2M/ANAPC11/ANAPC1/ANAPC7/ANAPC15/UBA52/UBE2D4/ANAPC2/SOCS3/ELOB/FZR1	-0.0249339051452973
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	13/1195	103/9376	0.990275013202259	FAS/GNA14/TLR4/TGFB2/BDKRB2/C3/GNAO1/IRAK1/JUN/TGFB3/FADD/GNAL/TICAM1	-0.0379283454082662
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	15/1195	119/9376	0.98899476108435	RIPK1/FAS/MAP3K5/ATF4/CASP10/TRADD/CREB3/TRAF5/MAP2K7/MAP3K8/JUN/FADD/VEGFC/SOCS3/VCAM1	-0.0461747144667517
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	6/1195	47/9376	1.00162022611947	SOCS2/IRS1/PRKCE/CACNA1D/SOCS3/PRKCZ	0.00425572352476607
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	4/1195	31/9376	1.01239033607774	AKR1A1/GUSB/ALDH3A2/ALDH1B1	0.0264083139872836
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	18/1195	144/9376	0.980753138075314	WNT2/MAP2K2/FGFR1/WNT5B/TBX3/WNT5A/ID2/ID3/SKIL/JAK2/PCGF6/ID1/ID4/WNT2B/WNT9B/FZD10/LEFTY2/FZD4	-0.0889528103033999
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	23/1195	184/9376	0.980753138075314	PLCG2/BOC/WNT5B/WNT5A/CXCL12/EFNB2/GDF7/PLXNA2/NRP1/SSH1/LIMK2/EPHB4/SEMA3A/UNC5B/RAC3/PLXNA1/NTN1/RGS3/CAMK2G/ABLIM3/PRKCZ/MYL5/EPHB3	-0.100769761088603
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	31/1195	248/9376	0.980753138075314	BAX/MAP2K2/RIPK1/GAPDH/CYCS/ARPC5/TLR4/DYNLRB1/ARPC5L/CASP4/TRADD/RPS3/BCL2/HSP90AB1/HSP90B1/VPS16/VPS39/DNM2/IRAK1/CYTH2/MAP2K7/TXN/ARHGEF26/NOD1/JUN/RHOJ/FADD/PLEKHM1/MYL5/KLC2/BAK1	-0.117398987113384
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	9/1195	72/9376	0.980753138075314	NFKBIB/RIPK1/CASP10/TRADD/PIN1/IRF3/TANK/FADD/NLRX1	-0.0626552868466792
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	27/1195	217/9376	0.976233538360681	FGF10/MAP2K2/GSTM5/EPHX1/BAD/GSTM3/RPS6KB2/BCL6/GSTO1/AIP/ATF4/GSTM1/BCL2/HSP90AB1/HSP90B1/CREB3/JAK2/GSTM2/CYP1B1/GSTM4/CACNA1D/JUN/EPHX2/VEGFA/ADCY2/MGST2/ADRB1	-0.13537446725049
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/1195	15/9376	1.04613668061367	ST6GALNAC4/ST3GAL5	0.0683435048084519
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	9/1195	73/9376	0.967318163581131	PLCG2/BAX/MAP2K2/BAD/RASSF1/GADD45A/HGF/FHIT/BAK1	-0.107132876547844
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	4/1195	32/9376	0.980753138075314	PGM2/GALK1/PGM1/MGAM	-0.0416806899685819
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	21/1195	170/9376	0.969214865862663	RAB13/ACTN1/ARPC5/ARPC5L/MAP3K5/MYL6B/EPB41L4B/JAM3/CGNL1/PRKCE/HSPA4/PRKAG2/AFDN/MAGI1/CLDN10/CACNA1D/MAP2K7/JUN/PRKCZ/CLDN4/MYH11	-0.154809076594152
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	7/1195	57/9376	0.963546942670484	HSD17B12/PPT1/ACSF3/ACADVL/HADHA/ACOX3/MCAT	-0.105500161651837
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	13/1195	106/9376	0.962248361885214	MAP2K2/BAD/FGFR1/ATF4/BCL2/HSP90AB1/HSP90B1/INSRR/GSTP1/ZEB1/CREB3/PLAU/SLC19A1	-0.149387844630051
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	28/1195	227/9376	0.967791642858459	BAX/MAP2K2/RIPK1/FAS/CYCS/RPS6KB2/GNG4/CXCL12/CGAS/ATF4/TRADD/IRF3/ITGB3/ARHGEF11/GNAO1/ITPR3/CREB3/TAPBPL/ARHGEF1/TRAF5/PTGER3/RAC3/BID/VEGFA/ADCY2/FADD/BAK1/GNGT1	-0.187741845450196
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	6/1195	49/9376	0.960737767910511	XXYLT1/GALNT8/GALNT10/B3GLCT/FUT10/C1GALT1C1L	-0.105309713706068
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	5/1195	41/9376	0.956832329829575	MAP2K2/RASSF1/THBS1/DAPK3/VEGFA	-0.105866796448399
NA	NA	hsa04519	Cadherin signaling	50/1195	404/9376	0.971042710965657	WNT2/MAP2K2/ACTN1/FGFR1/LIMA1/WNT5B/CDH3/SCN5A/ARPC5/WNT5A/MYO1E/ARPC5L/PSENEN/LRP5/CDH13/MRAS/KRT10/VIM/LHFPL2/GABRE/PCDHGA10/PCDHGA5/PCDHGA8/AFDN/PCDHB4/PCDHGA3/VCL/RAC3/PCDHGC3/PCDHB15/WNT2B/PCDHGB6/PCDHA9/CIB2/PCDHGA7/PCDHA10/PCDHGA9/WNT9B/PCDHB14/FZD10/PCDHB16/PCDHGA6/TEAD4/PCDHGA2/PCDHB3/PCDHB12/FZD4/KDR/PCDHB9/PCDHB5	-0.227389468015638
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	8/1195	66/9376	0.951033346012426	SRD5A3/HSD17B12/CYP11A1/CYP1B1/HSD17B7/HSD17B1/HSD11B1L/LRTOMT	-0.152568174690348
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	13/1195	107/9376	0.953255386540492	LDHA/PGAM1/ATF4/LDHB/PDHA1/ITPR3/CREB3/PRKAG2/PHKA2/CAMK2G/ADCY2/PHKA1/PDE3B	-0.185854643032188
Human Diseases	Substance dependence	hsa05032	Morphine addiction	11/1195	91/9376	0.948420617039864	GRK5/PDE4D/GRK4/GNG4/PDE4B/GNAO1/GABRE/ADCY2/PDE3B/PDE4C/GNGT1	-0.188961043698735
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/1195	16/9376	0.980753138075314	A4GALT/B3GALNT1	-0.0294474974063882
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	17/1195	140/9376	0.952731619844591	MAP2K2/RPS6/ACTA2/RPS6KB2/TFAM/GNG4/MRAS/PRKCE/ITPR3/PRKAG2/HDAC4/MYLK/ADCY2/MYL3/MEF2B/PDE3B/GNGT1	-0.21535708786881
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	9/1195	75/9376	0.941523012552301	GPX7/HSPA5/ATF4/HSP90B1/ITPR3/CREB3/ADCY2/TSHR/TPO	-0.194319862748072
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	5/1195	42/9376	0.934050607690775	DLST/HADHA/ALDH3A2/CYP1B1/ALDH1B1	-0.163707259938279
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	7/1195	59/9376	0.930884334444366	MGLL/IRS1/PTGER3/ADCY2/TSHR/PDE3B/ADRB1	-0.203531131520535
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	13/1195	109/9376	0.935764462016813	RPS6KB2/NR1H3/TBC1D4/IRS1/PPARGC1B/PPP1R3B/PRKCE/CREB3/PRKAG2/SOCS3/PRKCZ/SLC27A5/SLC27A6	-0.257801492755103
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	11/1195	93/9376	0.928024474737931	MAP2K2/PLA2G4C/ATF4/ITPR3/CACNA1D/MAP2K7/JUN/CAMK2G/ADCY2/PLD2/PLD1	-0.266592873954395
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	28/1195	232/9376	0.946934064348579	FGF10/MAP2K2/LPAR1/ACTN1/FGFR1/ARPC5/ARPC5L/CXCL12/BDKRB2/MRAS/ITGB3/GSN/INSRR/SSH1/LIMK2/PIP5K1A/SPATA13/ARHGEF1/VCL/RAC3/MYLK/ITGA6/MYL5/ITGA11/ITGA9/C6/MYH11/ITGA2	-0.31279377706365
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/1195	17/9376	0.92306177701206	SEPHS2/TXNRD2	-0.121343993275604
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	13/1195	110/9376	0.927257512362115	CDC25B/ANAPC13/HSP90AB1/ANAPC11/MAD1L1/ANAPC1/ANAPC7/MAD2L2/ANAPC15/ADCY2/ANAPC2/PDE3B/FZR1	-0.293295053179369
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	3/1195	26/9376	0.905310588992597	PLA2G4C/ACOX3/PLA2G2A	-0.184777326110182
Organismal Systems	Endocrine system	hsa04924	Renin secretion	8/1195	69/9376	0.909684070098842	GUCY1A1/EDN3/KCNMA1/ITPR3/GUCY1B1/CACNA1D/PDE3B/ADRB1	-0.287773262701763
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	27/1195	226/9376	0.937356981523309	GRIA4/MAP2K2/PDE4D/BAD/GLI1/FXYD1/EDN3/PDE4B/CREB3/VIPR2/AFDN/CACNA1D/ACOX3/PTGER3/JUN/RAC3/CAMK2G/ADCY2/POMC/TSHR/PLD2/ATP2A1/OXT/PDE3B/PLD1/PDE4C/ADRB1	-0.364319773480245
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	9/1195	78/9376	0.905310588992597	C2/TLR4/IRF3/C3/IRF8/IRAK1/NOD1/JUN/TICAM1	-0.3209374074732
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	9/1195	78/9376	0.905310588992597	NFKBIB/TLR4/TGFB2/CYBA/C3/JAK2/IRAK1/JUN/TGFB3	-0.3209374074732
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	8/1195	70/9376	0.896688583383144	CYCS/SSPN/SGCE/CD55/RAC3/DTNA/BID/LAMA1	-0.331575327379502
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/1195	27/9376	0.871780567178057	HSD17B12/ACOX3/ACOT2	-0.254987885854082
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/1195	18/9376	0.871780567178057	ACSF3/MCAT	-0.208096596917392
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	8/1195	71/9376	0.884059166715776	MAP2K2/LDHA/FGFR1/PGAM1/NTRK1/LDHB/PDHA1/PDK1	-0.374777748241648
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	16/1195	139/9376	0.903139580385901	MAP2K2/ATF4/HSPA8/KRT10/BCL2/HSP90AB1/FKBP4/HSP90B1/CTSD/GNAO1/ITPR3/CREB3/JUN/ADCY2/POMC/SHC3	-0.439698180993182
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	3/1195	28/9376	0.840645546921698	A4GALT/B3GNT2/B3GALNT1	-0.322738118215116
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	4/1195	37/9376	0.848218930227298	RIMKLB/ADSL/CAD/ALDH5A1	-0.353536842065895
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	10/1195	89/9376	0.88157585444972	NSF/GNG4/GABARAPL2/HAP1/GNAO1/GABRE/CACNA1D/SLC38A5/ADCY2/GNGT1	-0.429006561848172
Human Diseases	Cancer: specific types	hsa05218	Melanoma	8/1195	73/9376	0.859838367627672	FGF10/BAX/MAP2K2/BAD/FGFR1/GADD45A/HGF/BAK1	-0.459457622430899
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	11/1195	99/9376	0.871780567178057	PLCG2/PLA2G4C/NTRK1/BDKRB2/PRKCE/ITPR3/HTR2B/CAMK2G/ADCY2/IL1RAP/TRPV1	-0.490155708541589
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	29/1195	250/9376	0.910138912133891	GRK5/PSD/GRK4/ARPC5/DNM3/ARPC5L/RAB11B/CAPZB/CLTA/LDLR/BIN1/SPART/HSPA8/DNM1/ACAP3/VPS28/AGAP9/DNM2/ASAP1/PIP5K1A/SMAP1/CYTH2/ARFGAP1/CHMP6/SNX32/TFRC/PRKCZ/PLD2/PLD1	-0.550386583181308
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	12/1195	108/9376	0.871780567178057	EIF4A3/NUP42/THOC3/PHAX/SNUPN/RAN/PNN/TPR/RANGAP1/SRRM1/IPO4/DDX19B	-0.512199453964063
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/1195	20/9376	0.784602510460251	CYP51A1/HSD17B7	-0.368533458709677
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/1195	10/9376	0.784602510460251	TST	-0.260453354372229
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	9/1195	83/9376	0.850773806523164	SFMBT2/ASXL3/CBX3/PCGF6/L3MBTL2/UBE2D4/PHC2/EPOP/CBX8	-0.521882258401164
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	12/1195	109/9376	0.863782580323212	MAP2K2/RIPK1/TLR4/IRF3/IFNAR2/IRAK1/MAP2K7/MAP3K8/JUN/TYK2/FADD/TICAM1	-0.546691990672141
NA	NA	hsa03272	Virion - Hepatitis viruses	5/1195	48/9376	0.817294281729428	LDLR/SCARB1/CLDN10/CD63/CLDN4	-0.485003513183098
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	18/1195	160/9376	0.882677824267782	CDH3/VSIR/NLGN2/NLGN4X/JAM3/CNTN1/NCAM2/SDC4/CLDN10/CD4/ITGA6/LRRC4B/ITGA9/CLDN4/PVR/PTPRM/VCAM1/MADCAM1	-0.572051674429642
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	3/1195	30/9376	0.784602510460251	SUCLA2/DLST/PDHA1	-0.451600870933658
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	10/1195	93/9376	0.843658613398119	ACTN1/FGFR1/SORBS1/PDCD10/AFDN/VCL/RAC3/MYL5/SNAI1/PTPRM	-0.579078782967573
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	5/1195	49/9376	0.800614806592093	ATF4/DLG4/CREB3/JUN/TH	-0.534793783174573
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	8/1195	76/9376	0.825897379431843	PLTP/NR1H3/SORBS1/ANGPTL4/ACOX3/ACOX2/SLC27A5/SLC27A6	-0.582420998392404
Human Diseases	Cancer: specific types	hsa05214	Glioma	8/1195	76/9376	0.825897379431843	PLCG2/BAX/MAP2K2/GADD45A/CAMK1D/CAMK2G/SHC3/BAK1	-0.582420998392404
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	11/1195	103/9376	0.837925011171142	COL16A1/COL21A1/SLC36A4/COL4A4/SLC36A1/SLC1A1/SLC15A1/COL4A5/COL4A1/COL27A1/COL8A1	-0.632107403967837
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	6/1195	59/9376	0.797900858095171	BAX/MAP2K2/BAD/GADD45A/MLH1/BAK1	-0.595139563520644
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	7/1195	68/9376	0.807679054885552	DHRS4L2/DHRS3/ALDH1A1/ADH1C/RDH13/RDH10/LRAT	-0.608302005270913
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	5/1195	50/9376	0.784602510460251	SRM/SAT2/GAMT/ALDH3A2/ALDH1B1	-0.583639031892583
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	5/1195	50/9376	0.784602510460251	LTBR/CXCL12/CCR10/TNFSF13B/MADCAM1	-0.583639031892583
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	8/1195	77/9376	0.815171439439222	BAX/MAP2K2/BAD/GADD45A/TGFB2/TGFB3/SHC3/BAK1	-0.622390155218608
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	9/1195	86/9376	0.821095650481658	PLCG2/MAP2K2/BAD/RPS6KB2/MAP2K7/JUN/CAMK2G/SHC3/NRG2	-0.636984203412903
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	9/1195	86/9376	0.821095650481658	VAMP2/KCNMB3/ATF4/KCNMA1/ITPR3/CREB3/CACNA1D/CAMK2G/ADCY2	-0.636984203412903
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	7/1195	69/9376	0.795973561336487	GRIA4/ATF4/CREB3/CACNA1D/JUN/CAMK2G/TH	-0.650088572368975
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	3/1195	32/9376	0.735564853556485	IGBP1/GABARAPL2/ATG101	-0.572656436090081
Organismal Systems	Nervous system	hsa04730	Long-term depression	6/1195	60/9376	0.784602510460251	MAP2K2/PLA2G4C/GUCY1A1/GNAO1/ITPR3/GUCY1B1	-0.639687577643444
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	7/1195	70/9376	0.784602510460251	NFKBIB/TRADD/IRS1/PRKAG2/JAK2/POMC/SOCS3	-0.691312687887511
Genetic Information Processing	Transcription	hsa03040	Spliceosome	27/1195	243/9376	0.871780567178057	EIF4A3/HNRNPA1/SNRPD1/DDX46/PHF5A/PQBP1/PRPF38B/PUF60/THOC3/SNRPD3/SF3A3/DHX16/TRA2B/PPIL1/HSPA8/LSM4/LSM3/U2AF1/BUD31/SYF2/SNRPB/SRSF3/SF3A2/RP9/YJU2/GPKOW/HNRNPA1L2	-0.773956681712107
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/1195	23/9376	0.682263052574131	CTSA/KLK1	-0.583072507171524
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	12/1195	115/9376	0.818715663088958	KCNQ3/GNG4/ATF4/BCL2/GNAO1/ITPR3/CREB3/JAK2/CACNA1D/CAMK2G/ADCY2/GNGT1	-0.74756103212573
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	14/1195	133/9376	0.825897379431843	MAP2K2/FBXO32/GADD45A/BCL6/DEPP1/TGFB2/GABARAPL2/HOMER1/IRS1/PRKAG2/BNIP3/TGFB3/BCL2L11/CDKN2B	-0.77284258876897
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	4/1195	43/9376	0.72986280042814	SCARB1/AGPAT2/PLPP1/PLA2G2A	-0.678538325566162
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	15/1195	142/9376	0.82880546879604	PLCG2/FHL2/TGFB2/CYBA/IFNAR2/ITGB3/ITPR3/RELB/MAP2K7/JUN/SQSTM1/TYK2/NFKB2/SOCS3/ATP2A1	-0.785607315044358
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	12/1195	116/9376	0.811657769441639	PLCG2/ACTN1/THY1/CXCL12/CYBA/JAM3/AFDN/CLDN10/VCL/MYL5/CLDN4/VCAM1	-0.780077237208614
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	10/1195	99/9376	0.792527788343688	BAX/MAP2K2/BAD/RPS6KB2/NOTCH1/BCL2/JUN/ADCY2/SHC3/NOTCH4	-0.793122280054935
Organismal Systems	Immune system	hsa04611	Platelet activation	13/1195	126/9376	0.809510526665338	PLCG2/PLA2G4C/GUCY1A1/TLN1/P2RY1/ITGB3/ITPR3/GUCY1B1/ARHGEF1/MYLK/ADCY2/PRKCZ/ITGA2	-0.822719482463578
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	22/1195	205/9376	0.842012450250025	BAX/ACTN1/BAD/LTBR/ATP6V0D1/ATF4/TRADD/IRF3/C3/GSN/MAD1L1/CREB3/VAC14/TRAF5/HDAC4/JUN/HDAC10/NFKB2/PMAIP1/BAK1/GTF2H4/CDKN2B	-0.874093401811052
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	16/1195	154/9376	0.815171439439222	MAP2K2/CACNB2/PLA2G4C/GUCY1A1/MYL6B/CAMK1D/GNAO1/ITPR3/PRKAG2/GUCY1B1/CACNA1D/JUN/MYLK/CAMK2G/ADCY2/OXT	-0.883859587563714
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	5/1195	55/9376	0.713275009509319	DEGS1/ASAH1/PLPP1/CERS4/SMPD2	-0.815045834668204
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/1195	14/9376	0.560430364614465	B3GNT2	-0.629033505133952
Organismal Systems	Digestive system	hsa04970	Salivary secretion	9/1195	93/9376	0.759292752058307	VAMP2/GUCY1A1/BST1/KCNMA1/ITPR3/GUCY1B1/ADCY2/ADRA1D/ADRB1	-0.89156469198075
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	14/1195	138/9376	0.795973561336487	MAP2K2/ARHGEF28/ARPC5/TLR4/ARPC5L/IRF3/PIP5K1A/IRAK1/ARHGEF1/MAP2K7/JUN/RAC3/CD4/TICAM1	-0.922791122122959
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/1195	36/9376	0.653835425383542	AKR1A1/GUSB/DCXR	-0.795292392714965
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	7/1195	75/9376	0.732295676429568	TKT/GAPDH/TPI1/PGAM1/ENO1/ALDOA/PHGDH	-0.889585282754149
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	10/1195	103/9376	0.761750010155584	EIF4A3/PABPN1/ETF1/SMG6/PNN/DAZAP1/SRRM1/BCL2L2-PABPN1/GSPT2/DDX19B	-0.929196933247623
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	16/1195	157/9376	0.799594915118727	MAP2K2/ATP8A2/GAS6/NR1H3/THBS1/UQCRFS1/MFGE8/TMEM30A/ITGB3/VPS16/ALOX5/VPS39/JAK2/CAMK2G/ATP2A1/AGER	-0.967794277714326
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	16/1195	157/9376	0.799594915118727	MAP2K2/GADD45A/SLC25A6/TGFB2/SLC25A5/VDAC1/VDAC2/MRAS/CHEK2/ATR/ITPR3/CACNA1D/SQSTM1/TGFB3/E2F5/CDKN2B	-0.967794277714326
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	7/1195	76/9376	0.722660207002863	ITPR3/SLC26A7/GAST/MYLK/HRH2/CAMK2G/ADCY2	-0.927777644036673
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/1195	37/9376	0.636164197670474	FAS/LAMA4/VCAM1	-0.84746642502072
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	12/1195	122/9376	0.771740174223198	PLCG2/MAP2K2/SOCS2/ATF4/IRS1/ITPR3/CREB3/JAK2/CACNA1D/ADCY2/SOCS3/SHC3	-0.969864456665503
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	6/1195	69/9376	0.682263052574131	PLCG2/MAP2K2/PLA2G4C/ALOX5/MAP2K7/RAC3	-1.01240388203619
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	11/1195	117/9376	0.737660479919894	MORF4L2/SMARCB1/SMARCD3/CHD3/POLE3/RUVBL2/ZNHIT1/INO80E/DMAP1/GATAD2B/TFPT	-1.09129207926976
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	8/1195	89/9376	0.705260683559776	MAP2K2/LPAR1/GUCY1A1/ITPR3/HTR2B/GUCY1B1/ADCY2/ADRB1	-1.06773074190192
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	15/1195	154/9376	0.764223224474271	TPM1/TPM4/CACNB2/SCN5A/TPM2/ATF4/BCL2/CREB3/CACNA1D/CAMK2G/ADCY2/MYL3/ATP2A1/ADRA1D/ADRB1	-1.12749654566912
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/1195	29/9376	0.541105179627759	GUCA1B/GNGT1	-0.945893906828886
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	8/1195	90/9376	0.697424453742445	BAX/RPS6KB2/ATF4/IRS1/ATG101/CREB3/PRKAG2/ADCY2	-1.10231860007691
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	8/1195	90/9376	0.697424453742445	MAP2K2/NFKBIB/RPS6KB2/TLR4/JAK2/JUN/CD4/TICAM1	-1.10231860007691
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	15/1195	155/9376	0.759292752058307	ATP6V0C/ATP6V0D1/TLR4/THBS1/CYBA/SCARB1/ATP6V1E2/C3/ITGB3/ATP6V0A2/THBS2/ATP6V1G2/TFRC/ITGA2/ATP6V1C2	-1.15486813926678
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	6/1195	71/9376	0.663044375036832	MAP2K2/SOCS2/JAK2/SOCS3/SHC3/TH	-1.08920616493651
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	9/1195	100/9376	0.706142259414226	CD59/CD55/ITGB3/KITLG/CD4/ITGA6/TFRC/CSF3R/ITGA2	-1.12907595735826
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	18/1195	183/9376	0.771740174223198	NOP56/POP5/NHP2/IMP3/EIF6/MPHOSPH10/RBM28/GNL2/RIOK1/RPP25L/AK6/RAN/RIOK2/POP7/RRP7A/MDN1/UTP15/POP1	-1.19177093816825
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	20/1195	201/9376	0.780699015383334	BAX/HOXA11/NGFR/GADD45A/NFKBIZ/NUPR1/BCL6/NTRK1/ID2/SUPT3H/KLF3/ZEB1/HOXA9/ELANE/ASPSCR1/PLAU/RUNX2/WT1/BAK1/DOT1L	-1.20116306190709
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/1195	30/9376	0.523068340306834	PLA2G4C/PLA2G2A	-0.999931583945052
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	5/1195	62/9376	0.63274396004859	RPS6KB2/IRS1/HSPA8/PRKAG2/ADCY2	-1.10882515397851
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	5/1195	62/9376	0.63274396004859	PSENEN/NOTCH1/TLE2/NCOR2/NOTCH4	-1.10882515397851
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	7/1195	82/9376	0.669782630880702	HSPA5/RFXANK/HSPA8/HSP90AB1/HSPA4/TAPBPL/CD4	-1.14781500976192
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	11/1195	122/9376	0.707428493037931	PLCG2/MAP2K2/BAD/DIO2/PLCD3/TBC1D4/NOTCH1/ITGB3/MED24/ATP2A1/NOTCH4	-1.24312153779104
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	17/1195	178/9376	0.749339476282262	SERPINF1/WNT2/SFRP1/WNT5B/WNT5A/LRP5/TLE2/FRAT2/JUN/RAC3/CAMK2G/WNT2B/BAMBI/WNT9B/FZD10/PORCN/FZD4	-1.29037409504983
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	12/1195	133/9376	0.707912039513008	GRIA4/GNG4/ATF4/GNAO1/ITPR3/CREB3/CACNA1D/CAMK2G/GNAL/TH/LRTOMT/GNGT1	-1.29658022834093
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	3/1195	44/9376	0.534956257131989	TAF7/ERCC2/GTF2H4	-1.18167806245793
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	10/1195	115/9376	0.682263052574131	PLA2G4C/GNG4/CYP4X1/GNAO1/ALOX5/ITPR3/HTR2B/CACNA1D/KCND2/GNGT1	-1.3102497679031
NA	NA	hsa04082	Neuroactive ligand signaling	19/1195	199/9376	0.749117974811295	GRIA4/ADRA2C/GRM7/GNG4/P2RY1/GNAO1/GABRE/HTR2B/OGFRL1/P2RY11/HRH2/ADCY2/SLC1A1/GNAL/POMC/SLC1A2/ADRA1D/ADRB1/GNGT1	-1.36713724076196
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	5/1195	66/9376	0.594395841257766	TLR4/TGFB2/JUN/TGFB3/RORA	-1.26376382919322
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	2/1195	33/9376	0.475516673006213	DLST/PDHA1	-1.15348480218115
NA	NA	hsa04081	Hormone signaling	21/1195	219/9376	0.752358571674213	IGF2/PTH1R/RAMP1/GNA14/ADRA2C/DIO2/GNG4/IRS1/ITGB3/GNAO1/AVPR1A/VIPR2/JAK2/GAST/ADCY2/POMC/TSHR/OXT/ADRA1D/ADRB1/GNGT1	-1.41721305756478
Cellular Processes	Cell motility	hsa04814	Motor proteins	18/1195	194/9376	0.727981710736315	TPM1/ACTA2/TPM4/MYO1E/DYNLRB1/TPM2/CAPZB/MYL6B/KIF9/KIF1C/MYO19/DNAH14/DNAH1/MYL3/MYL5/KLC2/MYH11/MYO18A	-1.46317650978729
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	12/1195	138/9376	0.682263052574131	ANAPC13/FBXO5/ANAPC11/MAD1L1/ITPR3/ANAPC1/ANAPC7/MAD2L2/ANAPC15/CAMK2G/ADCY2/ANAPC2	-1.43709235026448
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/1195	23/9376	0.341131526287066	CAD	-1.20907592263473
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/1195	23/9376	0.341131526287066	RXYLT1	-1.20907592263473
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/1195	23/9376	0.341131526287066	CA4	-1.20907592263473
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	8/1195	102/9376	0.61537451800804	BST1/KCNMA1/ITPR3/ADCY2/PLA2G2A/TPCN2/ATP2A1/SLC26A3	-1.49269469071689
Organismal Systems	Digestive system	hsa04978	Mineral absorption	4/1195	61/9376	0.514493449482132	SLC39A4/STEAP2/STEAP1/SLC26A3	-1.45390147197252
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	2/1195	38/9376	0.412948689715922	RFXANK/CD4	-1.38582157957377
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	8/1195	105/9376	0.597792388922096	PLCG2/MRAS/ITPR3/RELB/JUN/NFKB2/KSR1/CARD9	-1.58397396166255
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	17/1195	195/9376	0.684012445016629	PLCG2/MAP2K2/SLC25A6/TLR4/CYBA/SLC25A5/CASP4/VDAC1/VDAC2/C3/ITGB3/ELANE/HDAC4/HDAC10/C5AR1/AGER/CLCN4	-1.70415339845106
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/1195	26/9376	0.301770196330866	NKX6-1	-1.36252865827134
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	4/1195	65/9376	0.482832314129385	MAP2K2/ITPR3/CACNA1D/CACNA1H	-1.59902881740389
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	2/1195	41/9376	0.38273293193183	GRIA4/GABRE	-1.51382010637775
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	8/1195	109/9376	0.575855053548808	NFKBIB/HSP90AB1/JAK2/JUN/TYK2/CD4/RORA/IL1RAP	-1.70225398234029
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	3/1195	54/9376	0.435890283589028	FAS/TSHR/TPO	-1.58881124650797
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	7/1195	99/9376	0.554769451840582	C2/CFI/KRT10/C3/CFD/DEFB1/C5AR1	-1.70202199459497
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	4/1195	67/9376	0.468419409230001	MAP2K2/ATF4/ITPR3/CAMK2G	-1.6688657285538
Organismal Systems	Digestive system	hsa04976	Bile secretion	6/1195	90/9376	0.523068340306834	EPHX1/LDLR/ABCC3/SCARB1/ADCY2/SLC27A5	-1.73751859972789
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	4/1195	68/9376	0.46153088850603	MAP2K2/BAD/RPS6KB2/PIM1	-1.70315219750666
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	2/1195	44/9376	0.35663750475466	FAS/HSPD1	-1.63478674533073
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	6/1195	93/9376	0.506195168038872	NFKBIB/NOTCH1/JAK2/JUN/TYK2/CD4	-1.82902241902028
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	6/1195	94/9376	0.500810113059735	TRADD/HSP90AB1/HSP90B1/TRAF5/JUN/FADD	-1.85898256949382
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/1195	48/9376	0.326917712691771	CACNA1D/MGAM	-1.78673813329896
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	15/1195	193/9376	0.6097946972489	PLCG2/GRK5/NFKBIB/BAD/GRK4/GNG4/CXCL12/CXCL14/JAK2/RAC3/ADCY2/SHC3/PRKCZ/CCR10/GNGT1	-2.09336965219051
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	5/1195	91/9376	0.431100280472665	PLCG2/MAP2K2/NFKBIB/JUN/RAC3	-2.08416383819259
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/1195	38/9376	0.206474344857961	IRS1	-1.87323485626684
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/1195	39/9376	0.201180130887244	FAS	-1.9104860776927
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	32/1195	370/9376	0.678575144181839	GRIA4/LPAR1/PTH1R/GAL/EDNRB/ADRA2C/GRM7/TMEM97/F2RL2/EDN3/BDKRB2/C3/P2RY1/GALR1/GABRE/AVPR1A/VIPR2/HTR2B/OGFRL1/NMB/PTGER3/P2RY11/HRH2/POMC/TSHR/OXT/ADM/C5AR1/ADRA1D/TRPV1/NPW/ADRB1	-2.41090858252489
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	8/1195	133/9376	0.471941359675339	PLCG2/MAP2K2/FAS/IFNAR2/RAC3/BID/SHC3/MICB	-2.34405550748485
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	7/1195	122/9376	0.450181768296865	RPS6KB2/TBC1D1/RAB11B/IRS1/PFKFB3/CREB3/PRKAG2	-2.33614986229321
Organismal Systems	Sensory system	hsa04742	Taste transduction	4/1195	86/9376	0.36493140021407	P2RY1/ENTPD2/ITPR3/TAS2R1	-2.26114494832734
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	5/1195	100/9376	0.392301255230126	LTBR/CXCL12/CXCL14/TNFRSF10D/CCR10	-2.33493268092485
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/1195	45/9376	0.174356113435611	FAS	-2.1217847625148
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	8/1195	143/9376	0.43893846739035	SNRPD1/ACTN1/C2/SNRPD3/C3/SNRPB/ELANE/C6	-2.58388683488139
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	25/1195	323/9376	0.607277484876355	PLCG2/MAP2K2/TPM1/CDC25B/RASSF1/PIM1/PDCD4/TGFB2/THBS1/IRS1/NOTCH1/PRKCE/BCL2/ITGB3/VIM/ZEB1/CYP1B1/ABCC1/HDAC4/VEGFA/PLAU/TIMP3/BCL2L11/BAK1/NOTCH4	-2.74509384457091
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	10/1195	168/9376	0.467025303845387	SOCS2/PIM1/OSMR/IL13RA1/BCL2/IFNAR2/JAK2/TYK2/SOCS3/CSF3R	-2.66406594372208
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	6/1195	122/9376	0.385870087111599	MAP2K2/NFKBIB/MAP2K7/MAP3K8/JUN/CD4	-2.60940694341875
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	21/1195	298/9376	0.552907809384741	NGFR/FAS/LTBR/OSMR/ACVRL1/TGFB2/CXCL12/IL13RA1/GDF7/CXCL14/IFNAR2/TNFRSF10D/BMP2/CD4/TGFB3/EDA2R/IL1RAP/CSF3R/CCR10/TNFRSF12A/TNFSF13B	-2.99761961169982
Human Diseases	Substance dependence	hsa05034	Alcoholism	10/1195	191/9376	0.410786654691231	GNG4/ATF4/GNAO1/CREB3/HDAC4/HDAC10/SHC3/TH/SLC29A3/GNGT1	-3.14424278184089
NA	NA	hsa04382	Cornified envelope formation	10/1195	217/9376	0.361567977170623	KAZN/S100A13/KRT10/COL4A4/CLDN10/EPHX2/ITGA6/COL4A5/COL4A1/CLDN4	-3.63652765303504
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	3/1195	449/9376	0.052423330320284	CAMK2G/OR3A2/GNAL	-7.86413856372418