ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003735 structural constituent of ribosome 78/2568 175/18639 0.445714285714286 3.23507343124166 2.70923010695613e-23 3.49490683797341e-20 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 29/2568 68/18639 0.426470588235294 3.09539925783397 5.32382353933119e-09 3.43386618286862e-06 GO:0019843 rRNA binding 27/2568 65/18639 0.415384615384615 3.01493529834651 3.51002418980441e-08 1.5093104016159e-05 GO:0015399 primary active transmembrane transporter activity 48/2568 166/18639 0.289156626506024 2.09875014074992 2.61777144631384e-07 8.44231291436212e-05 GO:0009055 electron transfer activity 37/2568 116/18639 0.318965517241379 2.31510836287464 4.28886473002995e-07 0.000110652710034773 GO:0015078 proton transmembrane transporter activity 51/2568 185/18639 0.275675675675676 2.00090300580955 5.717360706742e-07 0.000122923255194953 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 23/2568 61/18639 0.377049180327869 2.73668990347786 2.70717875496756e-06 0.000498894370558308 GO:0016853 isomerase activity 46/2568 180/18639 0.255555555555556 1.85486760124611 1.77835281501732e-05 0.00286759391421543 GO:0043022 ribosome binding 32/2568 112/18639 0.285714285714286 2.0737650200267 3.18729846053215e-05 0.00456201551301924 GO:0003954 NADH dehydrogenase activity 17/2568 44/18639 0.386363636363636 2.80429587935429 3.70382442640451e-05 0.00456201551301924 GO:0022853 active monoatomic ion transmembrane transporter activity 33/2568 118/18639 0.279661016949153 2.02982932044987 3.89009074753578e-05 0.00456201551301924 GO:0008137 NADH dehydrogenase (ubiquinone) activity 16/2568 41/18639 0.390243902439024 2.83245953954867 5.41197462615952e-05 0.00544276629864897 GO:0043021 ribonucleoprotein complex binding 44/2568 177/18639 0.248587570621469 1.80429272928877 5.4849582854602e-05 0.00544276629864897 GO:0043295 glutathione binding 7/2568 10/18639 0.7 5.08072429906542 7.65159466073588e-05 0.00705039793739235 GO:0008135 translation factor activity, RNA binding 25/2568 83/18639 0.301204819277108 2.18619806328116 8.85145221284446e-05 0.00761224890304623 GO:0180051 translation factor activity 25/2568 84/18639 0.297619047619048 2.16017189586115 0.000109719536016055 0.00884613759129445 GO:0022804 active transmembrane transporter activity 91/2568 457/18639 0.199124726477024 1.44528262336653 0.000154152533055266 0.0116974569200761 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 19/2568 58/18639 0.327586206896552 2.37767885916855 0.000179893330421756 0.0125793173325705 GO:1900750 oligopeptide binding 7/2568 11/18639 0.636363636363636 4.61884027187766 0.00018527676691383 0.0125793173325705 GO:0140101 catalytic activity, acting on a tRNA 35/2568 139/18639 0.251798561151079 1.82759866872857 0.000232108988841235 0.014480562786366 GO:0031625 ubiquitin protein ligase binding 64/2568 302/18639 0.211920529801325 1.5381568360463 0.000246483577723528 0.014480562786366 GO:0016651 oxidoreductase activity, acting on NAD(P)H 25/2568 88/18639 0.284090909090909 2.0619822642311 0.000246955334341125 0.014480562786366 GO:0008175 tRNA methyltransferase activity 13/2568 34/18639 0.382352941176471 2.77518554150632 0.000341376697693099 0.0191467800010477 GO:0016741 transferase activity, transferring one-carbon groups 48/2568 215/18639 0.223255813953488 1.62043034123017 0.000415285451476209 0.0223215930168462 GO:0016860 intramolecular oxidoreductase activity 17/2568 53/18639 0.320754716981132 2.32809469229413 0.000512149787601535 0.0260311267258877 GO:0044389 ubiquitin-like protein ligase binding 66/2568 322/18639 0.204968944099379 1.48770099262785 0.000524658368118667 0.0260311267258877 GO:0016675 oxidoreductase activity, acting on a heme group of donors 8/2568 16/18639 0.5 3.62908878504673 0.000587858765501473 0.0280865854628481 GO:0140098 catalytic activity, acting on RNA 76/2568 387/18639 0.196382428940568 1.42537854089691 0.00078401265791947 0.0359092168190578 GO:0008168 methyltransferase activity 45/2568 204/18639 0.220588235294118 1.60106858163826 0.000807261463374168 0.0359092168190578 GO:0070513 death domain binding 6/2568 10/18639 0.6 4.35490654205607 0.000867345502223766 0.0372958565956219 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 38/2568 167/18639 0.227544910179641 1.6515613632548 0.00108341872364511 0.0450841985000706 GO:0003746 translation elongation factor activity 8/2568 18/18639 0.444444444444444 3.22585669781931 0.0015470171588299 0.0623641292153305 GO:1990948 ubiquitin ligase inhibitor activity 6/2568 11/18639 0.545454545454545 3.9590059473237 0.0016858279845957 0.0659005484887408 GO:0140662 ATP-dependent protein folding chaperone 13/2568 40/18639 0.325 2.35890771028037 0.00198964078011761 0.072236003427085 GO:0004364 glutathione transferase activity 10/2568 27/18639 0.37037037037037 2.68821391484943 0.0021754078426068 0.072236003427085 GO:0004129 cytochrome-c oxidase activity 7/2568 15/18639 0.466666666666667 3.38714953271028 0.00217862874015065 0.072236003427085 GO:0055105 ubiquitin-protein transferase inhibitor activity 7/2568 15/18639 0.466666666666667 3.38714953271028 0.00217862874015065 0.072236003427085 GO:0051087 protein-folding chaperone binding 31/2568 134/18639 0.23134328358209 1.67913063188729 0.0022605082801396 0.072236003427085 GO:0044183 protein folding chaperone 20/2568 75/18639 0.266666666666667 1.93551401869159 0.00230209311228456 0.072236003427085 GO:0099186 structural constituent of postsynapse 9/2568 23/18639 0.391304347826087 2.84015644047135 0.00232093304112701 0.072236003427085 GO:0003756 protein disulfide isomerase activity 8/2568 19/18639 0.421052631578947 3.05607476635514 0.00235186987902137 0.072236003427085 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 8/2568 19/18639 0.421052631578947 3.05607476635514 0.00235186987902137 0.072236003427085 GO:0016866 intramolecular transferase activity 10/2568 28/18639 0.357142857142857 2.59220627503338 0.00297124492704234 0.0891373478112701 GO:0140597 protein carrier chaperone 40/2568 188/18639 0.212765957446809 1.54429310001988 0.00304642122501455 0.0893155313697446 GO:0016829 lyase activity 42/2568 200/18639 0.21 1.52421728971963 0.0031420648935372 0.0900725269480664 GO:0008173 RNA methyltransferase activity 18/2568 67/18639 0.26865671641791 1.94995815315944 0.00341330694923741 0.0927917797637881 GO:0008142 oxysterol binding 7/2568 16/18639 0.4375 3.17545268691589 0.00341589427598891 0.0927917797637881 GO:0016504 peptidase activator activity 16/2568 57/18639 0.280701754385965 2.03738317757009 0.00349880582546275 0.0927917797637881 GO:0051082 unfolded protein binding 28/2568 121/18639 0.231404958677686 1.67957828068278 0.00356994671348036 0.0927917797637881 GO:0140104 molecular carrier activity 50/2568 249/18639 0.200803212851406 1.45746537552077 0.00359658061099954 0.0927917797637881 GO:0016887 ATP hydrolysis activity 77/2568 417/18639 0.184652278177458 1.34023902373428 0.00409713005624093 0.103633289657859 GO:0016835 carbon-oxygen lyase activity 20/2568 79/18639 0.253164556962025 1.83751330888442 0.00441486397595026 0.109522587095689 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 12/2568 39/18639 0.307692307692308 2.2332854061826 0.00485045965718199 0.114773283609445 GO:0009982 pseudouridine synthase activity 6/2568 13/18639 0.461538461538462 3.3499281092739 0.00489343457249573 0.114773283609445 GO:0035673 oligopeptide transmembrane transporter activity 6/2568 13/18639 0.461538461538462 3.3499281092739 0.00489343457249573 0.114773283609445 GO:0030169 low-density lipoprotein particle binding 7/2568 17/18639 0.411764705882353 2.98866135239142 0.00512328483919648 0.115948025308131 GO:0051787 misfolded protein binding 7/2568 17/18639 0.411764705882353 2.98866135239142 0.00512328483919648 0.115948025308131 GO:0045296 cadherin binding 63/2568 334/18639 0.188622754491018 1.36905744585595 0.00546042298665742 0.121447338841174 GO:0016209 antioxidant activity 21/2568 86/18639 0.244186046511628 1.7723456857205 0.00563266731918596 0.123154929521185 GO:0055106 ubiquitin-protein transferase regulator activity 11/2568 36/18639 0.305555555555556 2.21777647975078 0.00728657356214888 0.151505207823821 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 7/2568 18/18639 0.388888888888889 2.8226246105919 0.00739909154488428 0.151505207823821 GO:0031690 adrenergic receptor binding 7/2568 18/18639 0.388888888888889 2.8226246105919 0.00739909154488428 0.151505207823821 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 7/2568 18/18639 0.388888888888889 2.8226246105919 0.00739909154488428 0.151505207823821 GO:0008559 ABC-type xenobiotic transporter activity 6/2568 14/18639 0.428571428571429 3.11064753004005 0.00757507682901522 0.152685142334838 GO:0030515 snoRNA binding 10/2568 32/18639 0.3125 2.26818049065421 0.00870187260078528 0.171756286646676 GO:0004601 peroxidase activity 15/2568 57/18639 0.263157894736842 1.91004672897196 0.00878753094471368 0.171756286646676 GO:0004602 glutathione peroxidase activity 8/2568 23/18639 0.347826086956522 2.5245835026412 0.00918334982382682 0.176813750339352 GO:0048027 mRNA 5'-UTR binding 8/2568 24/18639 0.333333333333333 2.41939252336449 0.0121427117668604 0.22787239132898 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 15/2568 59/18639 0.254237288135593 1.84529938222715 0.0121885232571315 0.22787239132898 GO:0005201 extracellular matrix structural constituent 34/2568 168/18639 0.202380952380952 1.46891688918558 0.0128328689001743 0.236491441160355 GO:0016722 oxidoreductase activity, acting on metal ions 6/2568 16/18639 0.375 2.72181658878505 0.0158267976556198 0.2875573095176 GO:0016836 hydro-lyase activity 15/2568 61/18639 0.245901639344262 1.78479776313774 0.0165376436967034 0.293079487175668 GO:0098918 structural constituent of synapse 9/2568 30/18639 0.3 2.17745327102804 0.0165851182665301 0.293079487175668 GO:0016423 tRNA (guanine) methyltransferase activity 5/2568 12/18639 0.416666666666667 3.02424065420561 0.016886175932064 0.294367120977872 GO:0003779 actin binding 77/2568 443/18639 0.173814898419865 1.26157939705913 0.0176197105365007 0.303059021227812 GO:0019838 growth factor binding 28/2568 136/18639 0.205882352941176 1.49433067619571 0.0180163848882654 0.303877351599996 GO:0003689 DNA clamp loader activity 32/2568 160/18639 0.2 1.45163551401869 0.0181384155606199 0.303877351599996 GO:0003743 translation initiation factor activity 13/2568 51/18639 0.254901960784314 1.85012369433755 0.0184682700841319 0.305436774468336 GO:0005178 integrin binding 32/2568 161/18639 0.198757763975155 1.4426191443664 0.0197352587004324 0.322259287639972 GO:0005112 Notch binding 8/2568 26/18639 0.307692307692308 2.2332854061826 0.0200624425516811 0.323506886145858 GO:0032977 membrane insertase activity 6/2568 17/18639 0.352941176470588 2.56170973062122 0.021665077373669 0.345036417432506 GO:1901682 sulfur compound transmembrane transporter activity 15/2568 63/18639 0.238095238095238 1.72813751668892 0.0219874814141843 0.345900622247533 GO:0005172 vascular endothelial growth factor receptor binding 5/2568 13/18639 0.384615384615385 2.79160675772825 0.0243816392817941 0.365769080833565 GO:0015252 proton channel activity 8/2568 27/18639 0.296296296296296 2.15057113187954 0.0251566696560198 0.365769080833565 GO:0140713 histone chaperone activity 32/2568 164/18639 0.195121951219512 1.41622976977433 0.0252011848456052 0.365769080833565 GO:0042910 xenobiotic transmembrane transporter activity 9/2568 32/18639 0.28125 2.04136244158878 0.0252352311582847 0.365769080833565 GO:0043425 bHLH transcription factor binding 9/2568 32/18639 0.28125 2.04136244158878 0.0252352311582847 0.365769080833565 GO:0071813 lipoprotein particle binding 9/2568 32/18639 0.28125 2.04136244158878 0.0252352311582847 0.365769080833565 GO:0071814 protein-lipid complex binding 9/2568 32/18639 0.28125 2.04136244158878 0.0252352311582847 0.365769080833565 GO:0008081 phosphoric diester hydrolase activity 19/2568 87/18639 0.218390804597701 1.5851192394457 0.0262226058993058 0.375857351223383 GO:0033218 amide binding 45/2568 247/18639 0.182186234817814 1.32234004313444 0.0291654581603819 0.41344440688893 GO:0042887 amide transmembrane transporter activity 10/2568 38/18639 0.263157894736842 1.91004672897196 0.0295454778811338 0.41427898333329 GO:0017134 fibroblast growth factor binding 7/2568 23/18639 0.304347826086957 2.20901056481105 0.0306950569427311 0.421904559479653 GO:0003724 RNA helicase activity 17/2568 77/18639 0.220779220779221 1.60245478820245 0.0310704908143931 0.421904559479653 GO:0051540 metal cluster binding 17/2568 77/18639 0.220779220779221 1.60245478820245 0.0310704908143931 0.421904559479653 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 48/2568 268/18639 0.17910447761194 1.29997210210629 0.0327843923524843 0.434349513270812 GO:0031072 heat shock protein binding 26/2568 131/18639 0.198473282442748 1.44055432688878 0.0335501482239226 0.434349513270812 GO:0005347 ATP transmembrane transporter activity 5/2568 14/18639 0.357142857142857 2.59220627503338 0.0337186184222269 0.434349513270812 GO:0008191 metalloendopeptidase inhibitor activity 5/2568 14/18639 0.357142857142857 2.59220627503338 0.0337186184222269 0.434349513270812 GO:0008195 phosphatidate phosphatase activity 5/2568 14/18639 0.357142857142857 2.59220627503338 0.0337186184222269 0.434349513270812 GO:0016776 phosphotransferase activity, phosphate group as acceptor 10/2568 39/18639 0.256410256410256 1.86107117181884 0.0349856284164232 0.434349513270812 GO:0005346 purine ribonucleotide transmembrane transporter activity 6/2568 19/18639 0.315789473684211 2.29205607476635 0.037315654644103 0.434349513270812 GO:0042577 lipid phosphatase activity 6/2568 19/18639 0.315789473684211 2.29205607476635 0.037315654644103 0.434349513270812 GO:0001094 TFIID-class transcription factor complex binding 4/2568 10/18639 0.4 2.90327102803738 0.0378805358269785 0.434349513270812 GO:0004090 carbonyl reductase (NADPH) activity 4/2568 10/18639 0.4 2.90327102803738 0.0378805358269785 0.434349513270812 GO:0008239 dipeptidyl-peptidase activity 4/2568 10/18639 0.4 2.90327102803738 0.0378805358269785 0.434349513270812 GO:0016868 intramolecular phosphotransferase activity 4/2568 10/18639 0.4 2.90327102803738 0.0378805358269785 0.434349513270812 GO:0016889 DNA endonuclease activity, producing 3'-phosphomonoesters 4/2568 10/18639 0.4 2.90327102803738 0.0378805358269785 0.434349513270812 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 4/2568 10/18639 0.4 2.90327102803738 0.0378805358269785 0.434349513270812 GO:0097177 mitochondrial ribosome binding 4/2568 10/18639 0.4 2.90327102803738 0.0378805358269785 0.434349513270812 GO:0000510 H3-H4 histone complex chaperone activity 29/2568 151/18639 0.19205298013245 1.39395463266696 0.0383843755913741 0.434349513270812 GO:0140584 chromatin extrusion motor activity 29/2568 151/18639 0.19205298013245 1.39395463266696 0.0383843755913741 0.434349513270812 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 29/2568 151/18639 0.19205298013245 1.39395463266696 0.0383843755913741 0.434349513270812 GO:0140849 ATP-dependent H2AZ histone chaperone activity 29/2568 151/18639 0.19205298013245 1.39395463266696 0.0383843755913741 0.434349513270812 GO:0008186 ATP-dependent activity, acting on RNA 17/2568 79/18639 0.215189873417722 1.56188631255176 0.0388544928766129 0.435846050528962 GO:0004519 endonuclease activity 25/2568 127/18639 0.196850393700787 1.42877511222312 0.0399311396655944 0.439260141121997 GO:0072341 modified amino acid binding 19/2568 91/18639 0.208791208791209 1.51544366848105 0.0399744089605715 0.439260141121997 GO:0001217 DNA-binding transcription repressor activity 49/2568 278/18639 0.176258992805755 1.27931906811 0.0401803850018571 0.439260141121997 GO:0015616 DNA translocase activity 29/2568 152/18639 0.190789473684211 1.38478387850467 0.0414078860577517 0.44513477512083 GO:0140674 ATP-dependent histone chaperone activity 29/2568 152/18639 0.190789473684211 1.38478387850467 0.0414078860577517 0.44513477512083 GO:0000049 tRNA binding 17/2568 80/18639 0.2125 1.54236273364486 0.0432360620835271 0.460946447006198 GO:0061775 cohesin loader activity 29/2568 153/18639 0.189542483660131 1.37573300348177 0.04460511079785 0.471213652551613 GO:0004089 carbonate dehydratase activity 5/2568 15/18639 0.333333333333333 2.41939252336449 0.0449915731892112 0.471213652551613 GO:0001968 fibronectin binding 8/2568 30/18639 0.266666666666667 1.93551401869159 0.0456624498231297 0.471213652551613 GO:0008106 alcohol dehydrogenase (NADP+) activity 8/2568 30/18639 0.266666666666667 1.93551401869159 0.0456624498231297 0.471213652551613 GO:0008094 ATP-dependent activity, acting on DNA 38/2568 210/18639 0.180952380952381 1.31338451268358 0.0460255195515529 0.471213652551613 GO:0005080 protein kinase C binding 12/2568 52/18639 0.230769230769231 1.67496405463695 0.0472050353769204 0.47654116662791 GO:0016505 peptidase activator activity involved in apoptotic process 6/2568 20/18639 0.3 2.17745327102804 0.0472847049057151 0.47654116662791 GO:0002020 protease binding 26/2568 136/18639 0.191176470588235 1.38759277075316 0.0501983170801425 0.501983170801425 GO:0140359 ABC-type transporter activity 11/2568 47/18639 0.234042553191489 1.69872241002187 0.0511800432713568 0.504301740070705 GO:0004033 aldo-keto reductase (NADPH) activity 9/2568 36/18639 0.25 1.81454439252336 0.0512120371699708 0.504301740070705 GO:0051536 iron-sulfur cluster binding 16/2568 76/18639 0.210526315789474 1.52803738317757 0.0525808288279013 0.512036686110561 GO:0015217 ADP transmembrane transporter activity 4/2568 11/18639 0.363636363636364 2.6393372982158 0.053188306929314 0.512036686110561 GO:0140031 phosphorylation-dependent protein binding 4/2568 11/18639 0.363636363636364 2.6393372982158 0.053188306929314 0.512036686110561 GO:0140296 general transcription initiation factor binding 12/2568 53/18639 0.226415094339623 1.64336095926644 0.0536667285151024 0.512815405810978 GO:0072349 modified amino acid transmembrane transporter activity 8/2568 31/18639 0.258064516129032 1.87307808260476 0.0543849631306573 0.513903090833192 GO:0004520 DNA endonuclease activity 10/2568 42/18639 0.238095238095238 1.72813751668892 0.0553740539734989 0.513903090833192 GO:0008307 structural constituent of muscle 10/2568 42/18639 0.238095238095238 1.72813751668892 0.0553740539734989 0.513903090833192 GO:0016859 cis-trans isomerase activity 10/2568 42/18639 0.238095238095238 1.72813751668892 0.0553740539734989 0.513903090833192 GO:0008198 ferrous iron binding 7/2568 26/18639 0.269230769230769 1.95412473040978 0.057086592919919 0.522281594799259 GO:0015216 purine nucleotide transmembrane transporter activity 7/2568 26/18639 0.269230769230769 1.95412473040978 0.057086592919919 0.522281594799259 GO:0022858 alanine transmembrane transporter activity 5/2568 16/18639 0.3125 2.26818049065421 0.0582482893408437 0.529156994716115 GO:0140658 ATP-dependent chromatin remodeler activity 29/2568 158/18639 0.183544303797468 1.3321971489412 0.0633637258556352 0.571602841634751 GO:0046906 tetrapyrrole binding 28/2568 152/18639 0.184210526315789 1.33703271028037 0.0646783954160971 0.579410625602537 GO:1901681 sulfur compound binding 47/2568 275/18639 0.170909090909091 1.24048853016143 0.0675456928869442 0.600923750511435 GO:0003714 transcription corepressor activity 36/2568 204/18639 0.176470588235294 1.28085486531061 0.0689442542053622 0.609164985787105 GO:0004526 ribonuclease P activity 4/2568 12/18639 0.333333333333333 2.41939252336449 0.071339372427939 0.611637223755127 GO:0016840 carbon-nitrogen lyase activity 4/2568 12/18639 0.333333333333333 2.41939252336449 0.071339372427939 0.611637223755127 GO:0034062 5'-3' RNA polymerase activity 6/2568 22/18639 0.272727272727273 1.97950297366185 0.0717226713159802 0.611637223755127 GO:0097747 RNA polymerase activity 6/2568 22/18639 0.272727272727273 1.97950297366185 0.0717226713159802 0.611637223755127 GO:0016790 thiolester hydrolase activity 10/2568 44/18639 0.227272727272727 1.64958581138488 0.0725880308817361 0.611637223755127 GO:0140097 catalytic activity, acting on DNA 56/2568 336/18639 0.166666666666667 1.20969626168224 0.0733189963555536 0.611637223755127 GO:0004549 tRNA-specific ribonuclease activity 5/2568 17/18639 0.294117647058824 2.13475810885102 0.0734912943271665 0.611637223755127 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 5/2568 17/18639 0.294117647058824 2.13475810885102 0.0734912943271665 0.611637223755127 GO:0070402 NADPH binding 5/2568 17/18639 0.294117647058824 2.13475810885102 0.0734912943271665 0.611637223755127 GO:0042626 ATPase-coupled transmembrane transporter activity 19/2568 98/18639 0.193877551020408 1.40719769216098 0.0754989501942522 0.624318241990932 GO:0020037 heme binding 26/2568 142/18639 0.183098591549296 1.3289620902988 0.077215485137054 0.634445705903183 GO:0051537 2 iron, 2 sulfur cluster binding 7/2568 28/18639 0.25 1.81454439252336 0.0806534393289385 0.658499599584372 GO:0000295 adenine nucleotide transmembrane transporter activity 6/2568 23/18639 0.260869565217391 1.8934376269809 0.0862030058006563 0.695011734267791 GO:0140102 catalytic activity, acting on a rRNA 6/2568 23/18639 0.260869565217391 1.8934376269809 0.0862030058006563 0.695011734267791 GO:0051015 actin filament binding 36/2568 209/18639 0.172248803827751 1.25021240441801 0.0907224074417355 0.712276791032921 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 4/2568 13/18639 0.307692307692308 2.2332854061826 0.0922094760484479 0.712276791032921 GO:0008035 high-density lipoprotein particle binding 4/2568 13/18639 0.307692307692308 2.2332854061826 0.0922094760484479 0.712276791032921 GO:0017154 semaphorin receptor activity 4/2568 13/18639 0.307692307692308 2.2332854061826 0.0922094760484479 0.712276791032921 GO:0019104 DNA N-glycosylase activity 4/2568 13/18639 0.307692307692308 2.2332854061826 0.0922094760484479 0.712276791032921 GO:0043560 insulin receptor substrate binding 4/2568 13/18639 0.307692307692308 2.2332854061826 0.0922094760484479 0.712276791032921 GO:0045159 myosin II binding 4/2568 13/18639 0.307692307692308 2.2332854061826 0.0922094760484479 0.712276791032921 GO:0043236 laminin binding 7/2568 29/18639 0.241379310344828 1.75197389622946 0.0942541035158923 0.723736866282744 GO:0001540 amyloid-beta binding 16/2568 83/18639 0.192771084337349 1.39916676049994 0.100755642911421 0.748780903870472 GO:0001091 RNA polymerase II general transcription initiation factor binding 6/2568 24/18639 0.25 1.81454439252336 0.102159255101708 0.748780903870472 GO:0042625 ATPase-coupled ion transmembrane transporter activity 6/2568 24/18639 0.25 1.81454439252336 0.102159255101708 0.748780903870472 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 6/2568 24/18639 0.25 1.81454439252336 0.102159255101708 0.748780903870472 GO:0046961 proton-transporting ATPase activity, rotational mechanism 6/2568 24/18639 0.25 1.81454439252336 0.102159255101708 0.748780903870472 GO:0050431 transforming growth factor beta binding 6/2568 24/18639 0.25 1.81454439252336 0.102159255101708 0.748780903870472 GO:0070300 phosphatidic acid binding 6/2568 24/18639 0.25 1.81454439252336 0.102159255101708 0.748780903870472 GO:0140612 DNA damage sensor activity 6/2568 24/18639 0.25 1.81454439252336 0.102159255101708 0.748780903870472 GO:0005525 GTP binding 61/2568 378/18639 0.161375661375661 1.17129320575582 0.103805523987587 0.756548734146822 GO:1901505 carbohydrate derivative transmembrane transporter activity 11/2568 53/18639 0.207547169811321 1.50641421266091 0.104784946229947 0.759396520430517 GO:0001965 G-protein alpha-subunit binding 7/2568 30/18639 0.233333333333333 1.69357476635514 0.109042867683255 0.768984954081009 GO:0015215 nucleotide transmembrane transporter activity 7/2568 30/18639 0.233333333333333 1.69357476635514 0.109042867683255 0.768984954081009 GO:0004860 protein kinase inhibitor activity 16/2568 84/18639 0.19047619047619 1.38251001335113 0.109334928758156 0.768984954081009 GO:0035591 signaling adaptor activity 23/2568 129/18639 0.178294573643411 1.29409367528798 0.114976968961021 0.768984954081009 GO:0001098 basal transcription machinery binding 12/2568 60/18639 0.2 1.45163551401869 0.115411928794683 0.768984954081009 GO:0001099 basal RNA polymerase II transcription machinery binding 12/2568 60/18639 0.2 1.45163551401869 0.115411928794683 0.768984954081009 GO:0004714 transmembrane receptor protein tyrosine kinase activity 12/2568 60/18639 0.2 1.45163551401869 0.115411928794683 0.768984954081009 GO:0008174 mRNA methyltransferase activity 4/2568 14/18639 0.285714285714286 2.0737650200267 0.115605819098936 0.768984954081009 GO:0008474 palmitoyl-(protein) hydrolase activity 4/2568 14/18639 0.285714285714286 2.0737650200267 0.115605819098936 0.768984954081009 GO:0016530 metallochaperone activity 4/2568 14/18639 0.285714285714286 2.0737650200267 0.115605819098936 0.768984954081009 GO:0031404 chloride ion binding 4/2568 14/18639 0.285714285714286 2.0737650200267 0.115605819098936 0.768984954081009 GO:0042043 neurexin family protein binding 4/2568 14/18639 0.285714285714286 2.0737650200267 0.115605819098936 0.768984954081009 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 4/2568 14/18639 0.285714285714286 2.0737650200267 0.115605819098936 0.768984954081009 GO:0098599 palmitoyl hydrolase activity 4/2568 14/18639 0.285714285714286 2.0737650200267 0.115605819098936 0.768984954081009 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 11/2568 54/18639 0.203703703703704 1.47851765316719 0.116062643407948 0.768984954081009 GO:0017069 snRNA binding 11/2568 54/18639 0.203703703703704 1.47851765316719 0.116062643407948 0.768984954081009 GO:0004386 helicase activity 27/2568 155/18639 0.174193548387097 1.26432770575822 0.116241911663408 0.768984954081009 GO:0050840 extracellular matrix binding 13/2568 67/18639 0.194029850746269 1.40830311061515 0.124887973837916 0.818428101011743 GO:0005310 dicarboxylic acid transmembrane transporter activity 7/2568 31/18639 0.225806451612903 1.63894332227917 0.124984756511096 0.818428101011743 GO:0001222 transcription corepressor binding 10/2568 49/18639 0.204081632653061 1.4812607285905 0.128822554551342 0.833764636459885 GO:0048156 tau protein binding 9/2568 43/18639 0.209302325581395 1.51915344490328 0.128868120273846 0.833764636459885 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 5/2568 20/18639 0.25 1.81454439252336 0.13055849346116 0.833764636459885 GO:0043024 ribosomal small subunit binding 5/2568 20/18639 0.25 1.81454439252336 0.13055849346116 0.833764636459885 GO:0140664 ATP-dependent DNA damage sensor activity 5/2568 20/18639 0.25 1.81454439252336 0.13055849346116 0.833764636459885 GO:0005085 guanyl-nucleotide exchange factor activity 38/2568 230/18639 0.165217391304348 1.19917716375457 0.132574255915069 0.842466946455368 GO:0019001 guanyl nucleotide binding 63/2568 400/18639 0.1575 1.14316296728972 0.139763720807765 0.843557666730173 GO:0032561 guanyl ribonucleotide binding 63/2568 400/18639 0.1575 1.14316296728972 0.139763720807765 0.843557666730173 GO:0016846 carbon-sulfur lyase activity 4/2568 15/18639 0.266666666666667 1.93551401869159 0.141283726702473 0.843557666730173 GO:0031005 filamin binding 4/2568 15/18639 0.266666666666667 1.93551401869159 0.141283726702473 0.843557666730173 GO:0031386 protein tag activity 4/2568 15/18639 0.266666666666667 1.93551401869159 0.141283726702473 0.843557666730173 GO:0050700 CARD domain binding 4/2568 15/18639 0.266666666666667 1.93551401869159 0.141283726702473 0.843557666730173 GO:0051371 muscle alpha-actinin binding 4/2568 15/18639 0.266666666666667 1.93551401869159 0.141283726702473 0.843557666730173 GO:0141047 molecular tag activity 4/2568 15/18639 0.266666666666667 1.93551401869159 0.141283726702473 0.843557666730173 GO:0019205 nucleobase-containing compound kinase activity 9/2568 44/18639 0.204545454545455 1.48462723024639 0.143340143260388 0.843557666730173 GO:0004862 cAMP-dependent protein kinase inhibitor activity 3/2568 10/18639 0.3 2.17745327102804 0.149057326417781 0.843557666730173 GO:0004935 adrenergic receptor activity 3/2568 10/18639 0.3 2.17745327102804 0.149057326417781 0.843557666730173 GO:0005131 growth hormone receptor binding 3/2568 10/18639 0.3 2.17745327102804 0.149057326417781 0.843557666730173 GO:0005528 FK506 binding 3/2568 10/18639 0.3 2.17745327102804 0.149057326417781 0.843557666730173 GO:0008140 cAMP response element binding protein binding 3/2568 10/18639 0.3 2.17745327102804 0.149057326417781 0.843557666730173 GO:0015643 toxic substance binding 3/2568 10/18639 0.3 2.17745327102804 0.149057326417781 0.843557666730173 GO:0016427 tRNA (cytidine) methyltransferase activity 3/2568 10/18639 0.3 2.17745327102804 0.149057326417781 0.843557666730173 GO:0016783 sulfurtransferase activity 3/2568 10/18639 0.3 2.17745327102804 0.149057326417781 0.843557666730173 GO:0031957 very long-chain fatty acid-CoA ligase activity 3/2568 10/18639 0.3 2.17745327102804 0.149057326417781 0.843557666730173 GO:0033204 ribonuclease P RNA binding 3/2568 10/18639 0.3 2.17745327102804 0.149057326417781 0.843557666730173 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 3/2568 10/18639 0.3 2.17745327102804 0.149057326417781 0.843557666730173 GO:0043121 neurotrophin binding 3/2568 10/18639 0.3 2.17745327102804 0.149057326417781 0.843557666730173 GO:0047429 nucleoside triphosphate diphosphatase activity 3/2568 10/18639 0.3 2.17745327102804 0.149057326417781 0.843557666730173 GO:0050815 phosphoserine residue binding 3/2568 10/18639 0.3 2.17745327102804 0.149057326417781 0.843557666730173 GO:1990757 ubiquitin ligase activator activity 3/2568 10/18639 0.3 2.17745327102804 0.149057326417781 0.843557666730173 GO:0061134 peptidase regulator activity 37/2568 226/18639 0.163716814159292 1.18828570837813 0.149093913189519 0.843557666730173 GO:0005123 death receptor binding 5/2568 21/18639 0.238095238095238 1.72813751668892 0.152999346035248 0.8618740453514 GO:0016874 ligase activity 28/2568 167/18639 0.167664670658683 1.21693995187196 0.155439225438926 0.866132399011826 GO:0098631 cell adhesion mediator activity 14/2568 76/18639 0.184210526315789 1.33703271028037 0.155820900200959 0.866132399011826 GO:0005021 vascular endothelial growth factor receptor activity 10/2568 51/18639 0.196078431372549 1.42317207256734 0.156440968193609 0.866132399011826 GO:0030544 Hsp70 protein binding 10/2568 51/18639 0.196078431372549 1.42317207256734 0.156440968193609 0.866132399011826 GO:0035255 ionotropic glutamate receptor binding 6/2568 27/18639 0.222222222222222 1.61292834890966 0.158280894805055 0.871569508468185 GO:0097110 scaffold protein binding 13/2568 70/18639 0.185714285714286 1.34794726301736 0.159805350562517 0.871569508468185 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 8/2568 39/18639 0.205128205128205 1.48885693745507 0.159972131691444 0.871569508468185 GO:0140416 transcription regulator inhibitor activity 7/2568 33/18639 0.212121212121212 1.53961342395922 0.160125560858108 0.871569508468185 GO:0004536 DNA nuclease activity 12/2568 64/18639 0.1875 1.36090829439252 0.163754363384503 0.887576171285753 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 4/2568 16/18639 0.25 1.81454439252336 0.168962205823016 0.89665754408347 GO:0097027 ubiquitin-protein transferase activator activity 4/2568 16/18639 0.25 1.81454439252336 0.168962205823016 0.89665754408347 GO:0019210 kinase inhibitor activity 16/2568 90/18639 0.177777777777778 1.29034267912773 0.169653152250591 0.89665754408347 GO:0003924 GTPase activity 52/2568 331/18639 0.157099697885196 1.14025750345879 0.170793002254156 0.89665754408347 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 10/2568 52/18639 0.192307692307692 1.39580337886413 0.17126607852127 0.89665754408347 GO:0030291 protein serine/threonine kinase inhibitor activity 9/2568 46/18639 0.195652173913043 1.42007822023568 0.174592742564625 0.89665754408347 GO:0008649 rRNA methyltransferase activity 5/2568 22/18639 0.227272727272727 1.64958581138488 0.176904250364445 0.89665754408347 GO:0061133 endopeptidase activator activity 5/2568 22/18639 0.227272727272727 1.64958581138488 0.176904250364445 0.89665754408347 GO:0070034 telomerase RNA binding 5/2568 22/18639 0.227272727272727 1.64958581138488 0.176904250364445 0.89665754408347 GO:0140517 protein-RNA adaptor activity 5/2568 22/18639 0.227272727272727 1.64958581138488 0.176904250364445 0.89665754408347 GO:0160215 deacylase activity 12/2568 65/18639 0.184615384615385 1.33997124370956 0.177223648826427 0.89665754408347 GO:0015036 disulfide oxidoreductase activity 8/2568 40/18639 0.2 1.45163551401869 0.177359994833031 0.89665754408347 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 8/2568 40/18639 0.2 1.45163551401869 0.177359994833031 0.89665754408347 GO:0015035 protein-disulfide reductase activity 7/2568 34/18639 0.205882352941176 1.49433067619571 0.179195950112623 0.89665754408347 GO:0046625 sphingolipid binding 6/2568 28/18639 0.214285714285714 1.55532376502003 0.179452019025814 0.89665754408347 GO:0051393 alpha-actinin binding 6/2568 28/18639 0.214285714285714 1.55532376502003 0.179452019025814 0.89665754408347 GO:0031593 polyubiquitin modification-dependent protein binding 11/2568 59/18639 0.186440677966102 1.35321954696658 0.182002024978468 0.89665754408347 GO:0000099 sulfur amino acid transmembrane transporter activity 3/2568 11/18639 0.272727272727273 1.97950297366185 0.185008208725956 0.89665754408347 GO:0005114 type II transforming growth factor beta receptor binding 3/2568 11/18639 0.272727272727273 1.97950297366185 0.185008208725956 0.89665754408347 GO:0008432 JUN kinase binding 3/2568 11/18639 0.272727272727273 1.97950297366185 0.185008208725956 0.89665754408347 GO:0010854 adenylate cyclase regulator activity 3/2568 11/18639 0.272727272727273 1.97950297366185 0.185008208725956 0.89665754408347 GO:0032050 clathrin heavy chain binding 3/2568 11/18639 0.272727272727273 1.97950297366185 0.185008208725956 0.89665754408347 GO:0034511 U3 snoRNA binding 3/2568 11/18639 0.272727272727273 1.97950297366185 0.185008208725956 0.89665754408347 GO:0035252 UDP-xylosyltransferase activity 3/2568 11/18639 0.272727272727273 1.97950297366185 0.185008208725956 0.89665754408347 GO:0042285 xylosyltransferase activity 3/2568 11/18639 0.272727272727273 1.97950297366185 0.185008208725956 0.89665754408347 GO:0043522 leucine zipper domain binding 3/2568 11/18639 0.272727272727273 1.97950297366185 0.185008208725956 0.89665754408347 GO:0050998 nitric-oxide synthase binding 3/2568 11/18639 0.272727272727273 1.97950297366185 0.185008208725956 0.89665754408347 GO:0180030 inositol phosphate kinase activity 3/2568 11/18639 0.272727272727273 1.97950297366185 0.185008208725956 0.89665754408347 GO:0005518 collagen binding 13/2568 72/18639 0.180555555555556 1.3105042834891 0.185587259124253 0.89665754408347 GO:0038064 collagen receptor activity 10/2568 53/18639 0.188679245283019 1.36946746605537 0.186726806961112 0.898796943954607 GO:0008201 heparin binding 28/2568 172/18639 0.162790697674419 1.18156379048033 0.196805763185238 0.931947314199969 GO:0042578 phosphoric ester hydrolase activity 56/2568 363/18639 0.154269972451791 1.11971885378852 0.197880968884131 0.931947314199969 GO:0004029 aldehyde dehydrogenase (NAD+) activity 4/2568 17/18639 0.235294117647059 1.70780648708081 0.198337870898662 0.931947314199969 GO:0004550 nucleoside diphosphate kinase activity 4/2568 17/18639 0.235294117647059 1.70780648708081 0.198337870898662 0.931947314199969 GO:0004659 prenyltransferase activity 4/2568 17/18639 0.235294117647059 1.70780648708081 0.198337870898662 0.931947314199969 GO:1990226 histone methyltransferase binding 4/2568 17/18639 0.235294117647059 1.70780648708081 0.198337870898662 0.931947314199969 GO:0004521 RNA endonuclease activity 13/2568 73/18639 0.178082191780822 1.29255217001664 0.199175160421631 0.931947314199969 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 15/2568 86/18639 0.174418604651163 1.26596120408607 0.199393378852086 0.931947314199969 GO:0003785 actin monomer binding 6/2568 29/18639 0.206896551724138 1.50169191105382 0.201677562202315 0.934267960466603 GO:0051861 glycolipid binding 6/2568 29/18639 0.206896551724138 1.50169191105382 0.201677562202315 0.934267960466603 GO:0008171 O-methyltransferase activity 5/2568 23/18639 0.217391304347826 1.57786468915075 0.202099040521053 0.934267960466603 GO:0051287 NAD binding 10/2568 54/18639 0.185185185185185 1.34410695742471 0.202786844132286 0.934267960466603 GO:0005543 phospholipid binding 75/2568 497/18639 0.150905432595573 1.09529842607044 0.21171639244244 0.963682757188387 GO:0003684 damaged DNA binding 13/2568 74/18639 0.175675675675676 1.2750852488002 0.213198308499538 0.963682757188387 GO:0001618 virus receptor activity 14/2568 81/18639 0.172839506172839 1.25449982692973 0.219744809435016 0.963682757188387 GO:0005484 SNAP receptor activity 7/2568 36/18639 0.194444444444444 1.41131230529595 0.219948491398834 0.963682757188387 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 7/2568 36/18639 0.194444444444444 1.41131230529595 0.219948491398834 0.963682757188387 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 7/2568 36/18639 0.194444444444444 1.41131230529595 0.219948491398834 0.963682757188387 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 7/2568 36/18639 0.194444444444444 1.41131230529595 0.219948491398834 0.963682757188387 GO:0005078 MAP-kinase scaffold activity 3/2568 12/18639 0.25 1.81454439252336 0.222897820825295 0.963682757188387 GO:0005527 macrolide binding 3/2568 12/18639 0.25 1.81454439252336 0.222897820825295 0.963682757188387 GO:0008179 adenylate cyclase binding 3/2568 12/18639 0.25 1.81454439252336 0.222897820825295 0.963682757188387 GO:0008603 cAMP-dependent protein kinase regulator activity 3/2568 12/18639 0.25 1.81454439252336 0.222897820825295 0.963682757188387 GO:0016208 AMP binding 3/2568 12/18639 0.25 1.81454439252336 0.222897820825295 0.963682757188387 GO:0017166 vinculin binding 3/2568 12/18639 0.25 1.81454439252336 0.222897820825295 0.963682757188387 GO:0035259 nuclear glucocorticoid receptor binding 3/2568 12/18639 0.25 1.81454439252336 0.222897820825295 0.963682757188387 GO:0004518 nuclease activity 33/2568 209/18639 0.157894736842105 1.14602803738318 0.224116986401088 0.963682757188387 GO:0035925 mRNA 3'-UTR AU-rich region binding 6/2568 30/18639 0.2 1.45163551401869 0.22483623583208 0.963682757188387 GO:0004857 enzyme inhibitor activity 63/2568 416/18639 0.151442307692308 1.0991951608555 0.22560653519166 0.963682757188387 GO:0035254 glutamate receptor binding 9/2568 49/18639 0.183673469387755 1.33313465573145 0.226612580049335 0.963682757188387 GO:0004622 lysophospholipase activity 5/2568 24/18639 0.208333333333333 1.5121203271028 0.228398984052459 0.963682757188387 GO:0015295 solute:proton symporter activity 5/2568 24/18639 0.208333333333333 1.5121203271028 0.228398984052459 0.963682757188387 GO:0000400 four-way junction DNA binding 4/2568 18/18639 0.222222222222222 1.61292834890966 0.22909697804666 0.963682757188387 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 4/2568 18/18639 0.222222222222222 1.61292834890966 0.22909697804666 0.963682757188387 GO:0004706 JUN kinase kinase kinase activity 4/2568 18/18639 0.222222222222222 1.61292834890966 0.22909697804666 0.963682757188387 GO:0008308 voltage-gated monoatomic anion channel activity 4/2568 18/18639 0.222222222222222 1.61292834890966 0.22909697804666 0.963682757188387 GO:0016854 racemase and epimerase activity 4/2568 18/18639 0.222222222222222 1.61292834890966 0.22909697804666 0.963682757188387 GO:0034185 apolipoprotein binding 4/2568 18/18639 0.222222222222222 1.61292834890966 0.22909697804666 0.963682757188387 GO:0008083 growth factor activity 26/2568 162/18639 0.160493827160494 1.16489269643475 0.229341555392895 0.963682757188387 GO:0140272 exogenous protein binding 14/2568 82/18639 0.170731707317073 1.23920104855254 0.233724543560626 0.977821141280909 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 20/2568 122/18639 0.163934426229508 1.18986517542516 0.23422227337659 0.977821141280909 GO:0019212 phosphatase inhibitor activity 10/2568 56/18639 0.178571428571429 1.29610313751669 0.236542278405309 0.984321094009189 GO:0019213 deacetylase activity 7/2568 37/18639 0.189189189189189 1.37316872947714 0.241454979269628 0.998323471980193 GO:0042805 actinin binding 7/2568 37/18639 0.189189189189189 1.37316872947714 0.241454979269628 0.998323471980193 GO:0015294 solute:monoatomic cation symporter activity 19/2568 116/18639 0.163793103448276 1.18883942958427 0.242652764840314 1 GO:0005006 epidermal growth factor receptor activity 9/2568 50/18639 0.18 1.30647196261682 0.245123774225098 1 GO:0032813 tumor necrosis factor receptor superfamily binding 9/2568 50/18639 0.18 1.30647196261682 0.245123774225098 1 GO:0019955 cytokine binding 23/2568 144/18639 0.159722222222222 1.15929225077882 0.253826814993871 1 GO:0016248 channel inhibitor activity 8/2568 44/18639 0.181818181818182 1.3196686491079 0.254139056747113 1 GO:0047617 fatty acyl-CoA hydrolase activity 5/2568 25/18639 0.2 1.45163551401869 0.255613597658657 1 GO:0005520 insulin-like growth factor binding 4/2568 19/18639 0.210526315789474 1.52803738317757 0.260925493173156 1 GO:0050145 nucleoside monophosphate kinase activity 4/2568 19/18639 0.210526315789474 1.52803738317757 0.260925493173156 1 GO:0097001 ceramide binding 4/2568 19/18639 0.210526315789474 1.52803738317757 0.260925493173156 1 GO:0005035 death receptor activity 3/2568 13/18639 0.230769230769231 1.67496405463695 0.262104324258349 1 GO:0008253 5'-nucleotidase activity 3/2568 13/18639 0.230769230769231 1.67496405463695 0.262104324258349 1 GO:0015651 quaternary ammonium group transmembrane transporter activity 3/2568 13/18639 0.230769230769231 1.67496405463695 0.262104324258349 1 GO:0031994 insulin-like growth factor I binding 3/2568 13/18639 0.230769230769231 1.67496405463695 0.262104324258349 1 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 3/2568 13/18639 0.230769230769231 1.67496405463695 0.262104324258349 1 GO:0140410 monoatomic cation:bicarbonate symporter activity 3/2568 13/18639 0.230769230769231 1.67496405463695 0.262104324258349 1 GO:0005109 frizzled binding 7/2568 38/18639 0.184210526315789 1.33703271028037 0.263590070816514 1 GO:0043531 ADP binding 7/2568 38/18639 0.184210526315789 1.33703271028037 0.263590070816514 1 GO:0005010 insulin-like growth factor receptor activity 9/2568 51/18639 0.176470588235294 1.28085486531061 0.264127232660417 1 GO:0001664 G protein-coupled receptor binding 45/2568 297/18639 0.151515151515152 1.09972387425658 0.267589435556702 1 GO:0017116 single-stranded DNA helicase activity 10/2568 58/18639 0.172413793103448 1.25140992587818 0.272178963118978 1 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 21/2568 132/18639 0.159090909090909 1.15471006796941 0.272254719260577 1 GO:0019199 transmembrane receptor protein kinase activity 13/2568 78/18639 0.166666666666667 1.20969626168224 0.273126700904772 1 GO:0008378 galactosyltransferase activity 6/2568 32/18639 0.1875 1.36090829439252 0.273439483298868 1 GO:0031369 translation initiation factor binding 6/2568 32/18639 0.1875 1.36090829439252 0.273439483298868 1 GO:0051539 4 iron, 4 sulfur cluster binding 8/2568 45/18639 0.177777777777778 1.29034267912773 0.274797450273529 1 GO:0141110 transporter inhibitor activity 8/2568 45/18639 0.177777777777778 1.29034267912773 0.274797450273529 1 GO:0015293 symporter activity 23/2568 146/18639 0.157534246575342 1.14341153501472 0.276280523932992 1 GO:0003712 transcription coregulator activity 73/2568 495/18639 0.147474747474747 1.07039790427641 0.281412391531549 1 GO:0052689 carboxylic ester hydrolase activity 15/2568 92/18639 0.16304347826087 1.18339851686306 0.281543924389598 1 GO:0004112 cyclic-nucleotide phosphodiesterase activity 5/2568 26/18639 0.192307692307692 1.39580337886413 0.283550951710719 1 GO:0004435 phosphatidylinositol phospholipase C activity 5/2568 26/18639 0.192307692307692 1.39580337886413 0.283550951710719 1 GO:0005160 transforming growth factor beta receptor binding 5/2568 26/18639 0.192307692307692 1.39580337886413 0.283550951710719 1 GO:0008157 protein phosphatase 1 binding 5/2568 26/18639 0.192307692307692 1.39580337886413 0.283550951710719 1 GO:0016289 acyl-CoA hydrolase activity 5/2568 26/18639 0.192307692307692 1.39580337886413 0.283550951710719 1 GO:0030247 polysaccharide binding 5/2568 26/18639 0.192307692307692 1.39580337886413 0.283550951710719 1 GO:0050750 low-density lipoprotein particle receptor binding 5/2568 26/18639 0.192307692307692 1.39580337886413 0.283550951710719 1 GO:0070412 R-SMAD binding 5/2568 26/18639 0.192307692307692 1.39580337886413 0.283550951710719 1 GO:0120014 phospholipid transfer activity 5/2568 26/18639 0.192307692307692 1.39580337886413 0.283550951710719 1 GO:0001786 phosphatidylserine binding 10/2568 59/18639 0.169491525423729 1.23019958815143 0.290582419882347 1 GO:0070063 RNA polymerase binding 10/2568 59/18639 0.169491525423729 1.23019958815143 0.290582419882347 1 GO:0010851 cyclase regulator activity 4/2568 20/18639 0.2 1.45163551401869 0.293517243101155 1 GO:0051219 phosphoprotein binding 15/2568 93/18639 0.161290322580645 1.17067380162798 0.296236091586319 1 GO:0071889 14-3-3 protein binding 6/2568 33/18639 0.181818181818182 1.3196686491079 0.29862035495237 1 GO:0005313 L-glutamate transmembrane transporter activity 3/2568 14/18639 0.214285714285714 1.55532376502003 0.302058462029098 1 GO:0005545 1-phosphatidylinositol binding 3/2568 14/18639 0.214285714285714 1.55532376502003 0.302058462029098 1 GO:0008331 high voltage-gated calcium channel activity 3/2568 14/18639 0.214285714285714 1.55532376502003 0.302058462029098 1 GO:0030983 mismatched DNA binding 3/2568 14/18639 0.214285714285714 1.55532376502003 0.302058462029098 1 GO:0032036 myosin heavy chain binding 3/2568 14/18639 0.214285714285714 1.55532376502003 0.302058462029098 1 GO:0042813 Wnt receptor activity 3/2568 14/18639 0.214285714285714 1.55532376502003 0.302058462029098 1 GO:0070742 C2H2 zinc finger domain binding 3/2568 14/18639 0.214285714285714 1.55532376502003 0.302058462029098 1 GO:0004864 protein phosphatase inhibitor activity 9/2568 53/18639 0.169811320754717 1.23252071944983 0.303370750244987 1 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 7/2568 40/18639 0.175 1.27018107476636 0.309355752611325 1 GO:0061791 GTPase motor activity 7/2568 40/18639 0.175 1.27018107476636 0.309355752611325 1 GO:0071949 FAD binding 7/2568 40/18639 0.175 1.27018107476636 0.309355752611325 1 GO:1990606 membrane scission GTPase motor activity 7/2568 40/18639 0.175 1.27018107476636 0.309355752611325 1 GO:0004683 calcium/calmodulin-dependent protein kinase activity 5/2568 27/18639 0.185185185185185 1.34410695742471 0.312021419189279 1 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 5/2568 27/18639 0.185185185185185 1.34410695742471 0.312021419189279 1 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 11/2568 67/18639 0.164179104477612 1.19164109359743 0.314106870661364 1 GO:0005504 fatty acid binding 8/2568 47/18639 0.170212765957447 1.23543448001591 0.317349390817632 1 GO:0044325 transmembrane transporter binding 21/2568 136/18639 0.154411764705882 1.12074800714678 0.32138196293484 1 GO:0050661 NADP binding 9/2568 54/18639 0.166666666666667 1.20969626168224 0.323487531467527 1 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 6/2568 34/18639 0.176470588235294 1.28085486531061 0.324211298846601 1 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 4/2568 21/18639 0.19047619047619 1.38251001335113 0.326580277704898 1 GO:0032934 sterol binding 11/2568 68/18639 0.161764705882353 1.17411695986806 0.332151317360497 1 GO:0015175 neutral L-amino acid transmembrane transporter activity 7/2568 41/18639 0.170731707317073 1.23920104855254 0.332789390319136 1 GO:0042169 SH2 domain binding 7/2568 41/18639 0.170731707317073 1.23920104855254 0.332789390319136 1 GO:0061650 ubiquitin-like protein conjugating enzyme activity 7/2568 41/18639 0.170731707317073 1.23920104855254 0.332789390319136 1 GO:0016798 hydrolase activity, acting on glycosyl bonds 20/2568 130/18639 0.153846153846154 1.1166427030913 0.333242667688944 1 GO:0035091 phosphatidylinositol binding 42/2568 284/18639 0.147887323943662 1.07339245754903 0.334248735936553 1 GO:0005539 glycosaminoglycan binding 36/2568 242/18639 0.148760330578512 1.07972889472465 0.335972248288229 1 GO:0016879 ligase activity, forming carbon-nitrogen bonds 8/2568 48/18639 0.166666666666667 1.20969626168224 0.339089039622238 1 GO:0051959 dynein light intermediate chain binding 5/2568 28/18639 0.178571428571429 1.29610313751669 0.340840854007424 1 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 5/2568 28/18639 0.178571428571429 1.29610313751669 0.340840854007424 1 GO:0097718 disordered domain specific binding 5/2568 28/18639 0.178571428571429 1.29610313751669 0.340840854007424 1 GO:0000774 adenyl-nucleotide exchange factor activity 3/2568 15/18639 0.2 1.45163551401869 0.342252145860755 1 GO:0004559 alpha-mannosidase activity 3/2568 15/18639 0.2 1.45163551401869 0.342252145860755 1 GO:0004865 protein serine/threonine phosphatase inhibitor activity 3/2568 15/18639 0.2 1.45163551401869 0.342252145860755 1 GO:0008242 omega peptidase activity 3/2568 15/18639 0.2 1.45163551401869 0.342252145860755 1 GO:0008252 nucleotidase activity 3/2568 15/18639 0.2 1.45163551401869 0.342252145860755 1 GO:0010181 FMN binding 3/2568 15/18639 0.2 1.45163551401869 0.342252145860755 1 GO:0015556 C4-dicarboxylate transmembrane transporter activity 3/2568 15/18639 0.2 1.45163551401869 0.342252145860755 1 GO:0017081 chloride channel regulator activity 3/2568 15/18639 0.2 1.45163551401869 0.342252145860755 1 GO:0033130 acetylcholine receptor binding 3/2568 15/18639 0.2 1.45163551401869 0.342252145860755 1 GO:0048531 beta-1,3-galactosyltransferase activity 3/2568 15/18639 0.2 1.45163551401869 0.342252145860755 1 GO:0061578 K63-linked deubiquitinase activity 3/2568 15/18639 0.2 1.45163551401869 0.342252145860755 1 GO:0008374 O-acyltransferase activity 9/2568 55/18639 0.163636363636364 1.18770178419711 0.343851245703073 1 GO:0005343 organic acid:sodium symporter activity 6/2568 35/18639 0.171428571428571 1.24425901201602 0.350082889609995 1 GO:0030165 PDZ domain binding 13/2568 83/18639 0.156626506024096 1.1368229929062 0.354446490176941 1 GO:0019894 kinesin binding 7/2568 42/18639 0.166666666666667 1.20969626168224 0.356460161622851 1 GO:0042056 chemoattractant activity 7/2568 42/18639 0.166666666666667 1.20969626168224 0.356460161622851 1 GO:0051879 Hsp90 protein binding 7/2568 42/18639 0.166666666666667 1.20969626168224 0.356460161622851 1 GO:1902936 phosphatidylinositol bisphosphate binding 17/2568 111/18639 0.153153153153153 1.1116127810053 0.358513833825824 1 GO:0015377 chloride:monoatomic cation symporter activity 4/2568 22/18639 0.181818181818182 1.3196686491079 0.359841617113887 1 GO:0016881 acid-amino acid ligase activity 4/2568 22/18639 0.181818181818182 1.3196686491079 0.359841617113887 1 GO:0140035 ubiquitin-like protein reader activity 4/2568 22/18639 0.181818181818182 1.3196686491079 0.359841617113887 1 GO:0005004 GPI-linked ephrin receptor activity 8/2568 49/18639 0.163265306122449 1.1850085828724 0.361035665880366 1 GO:0005008 hepatocyte growth factor receptor activity 8/2568 49/18639 0.163265306122449 1.1850085828724 0.361035665880366 1 GO:0005009 insulin receptor activity 8/2568 49/18639 0.163265306122449 1.1850085828724 0.361035665880366 1 GO:0005011 macrophage colony-stimulating factor receptor activity 8/2568 49/18639 0.163265306122449 1.1850085828724 0.361035665880366 1 GO:0005018 platelet-derived growth factor alpha-receptor activity 8/2568 49/18639 0.163265306122449 1.1850085828724 0.361035665880366 1 GO:0005020 stem cell factor receptor activity 8/2568 49/18639 0.163265306122449 1.1850085828724 0.361035665880366 1 GO:0008288 boss receptor activity 8/2568 49/18639 0.163265306122449 1.1850085828724 0.361035665880366 1 GO:0016763 pentosyltransferase activity 8/2568 49/18639 0.163265306122449 1.1850085828724 0.361035665880366 1 GO:0036332 placental growth factor receptor activity 8/2568 49/18639 0.163265306122449 1.1850085828724 0.361035665880366 1 GO:0038062 protein tyrosine kinase collagen receptor activity 8/2568 49/18639 0.163265306122449 1.1850085828724 0.361035665880366 1 GO:0060175 brain-derived neurotrophic factor receptor activity 8/2568 49/18639 0.163265306122449 1.1850085828724 0.361035665880366 1 GO:0004629 phospholipase C activity 5/2568 29/18639 0.172413793103448 1.25140992587818 0.369833206466822 1 GO:0005416 amino acid:monoatomic cation symporter activity 5/2568 29/18639 0.172413793103448 1.25140992587818 0.369833206466822 1 GO:0016417 S-acyltransferase activity 5/2568 29/18639 0.172413793103448 1.25140992587818 0.369833206466822 1 GO:0035250 UDP-galactosyltransferase activity 5/2568 29/18639 0.172413793103448 1.25140992587818 0.369833206466822 1 GO:0000993 RNA polymerase II complex binding 6/2568 36/18639 0.166666666666667 1.20969626168224 0.376109769252227 1 GO:0045505 dynein intermediate chain binding 6/2568 36/18639 0.166666666666667 1.20969626168224 0.376109769252227 1 GO:0005245 voltage-gated calcium channel activity 7/2568 43/18639 0.162790697674419 1.18156379048033 0.380273065320442 1 GO:0008200 ion channel inhibitor activity 7/2568 43/18639 0.162790697674419 1.18156379048033 0.380273065320442 1 GO:0005159 insulin-like growth factor receptor binding 3/2568 16/18639 0.1875 1.36090829439252 0.38224213202331 1 GO:0015562 efflux transmembrane transporter activity 3/2568 16/18639 0.1875 1.36090829439252 0.38224213202331 1 GO:0015923 mannosidase activity 3/2568 16/18639 0.1875 1.36090829439252 0.38224213202331 1 GO:0017070 U6 snRNA binding 3/2568 16/18639 0.1875 1.36090829439252 0.38224213202331 1 GO:0019841 retinol binding 3/2568 16/18639 0.1875 1.36090829439252 0.38224213202331 1 GO:0030275 LRR domain binding 3/2568 16/18639 0.1875 1.36090829439252 0.38224213202331 1 GO:0043023 ribosomal large subunit binding 3/2568 16/18639 0.1875 1.36090829439252 0.38224213202331 1 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 3/2568 16/18639 0.1875 1.36090829439252 0.38224213202331 1 GO:0005007 fibroblast growth factor receptor activity 8/2568 50/18639 0.16 1.16130841121495 0.38311412143375 1 GO:0005017 platelet-derived growth factor receptor activity 8/2568 50/18639 0.16 1.16130841121495 0.38311412143375 1 GO:0005019 platelet-derived growth factor beta-receptor activity 8/2568 50/18639 0.16 1.16130841121495 0.38311412143375 1 GO:0015605 organophosphate ester transmembrane transporter activity 8/2568 50/18639 0.16 1.16130841121495 0.38311412143375 1 GO:0015932 nucleobase-containing compound transmembrane transporter activity 9/2568 57/18639 0.157894736842105 1.14602803738318 0.385071774669072 1 GO:0042826 histone deacetylase binding 19/2568 127/18639 0.149606299212598 1.08586908528957 0.386847796589325 1 GO:0005212 structural constituent of eye lens 4/2568 23/18639 0.173913043478261 1.2622917513206 0.393050580607116 1 GO:0005283 amino acid:sodium symporter activity 4/2568 23/18639 0.173913043478261 1.2622917513206 0.393050580607116 1 GO:0016849 phosphorus-oxygen lyase activity 4/2568 23/18639 0.173913043478261 1.2622917513206 0.393050580607116 1 GO:0042171 lysophosphatidic acid acyltransferase activity 4/2568 23/18639 0.173913043478261 1.2622917513206 0.393050580607116 1 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 4/2568 23/18639 0.173913043478261 1.2622917513206 0.393050580607116 1 GO:0071617 lysophospholipid acyltransferase activity 4/2568 23/18639 0.173913043478261 1.2622917513206 0.393050580607116 1 GO:0004540 RNA nuclease activity 18/2568 121/18639 0.148760330578512 1.07972889472465 0.401551848395094 1 GO:0022829 wide pore channel activity 6/2568 37/18639 0.162162162162162 1.17700176812326 0.402171986668214 1 GO:0030020 extracellular matrix structural constituent conferring tensile strength 7/2568 44/18639 0.159090909090909 1.15471006796941 0.404136256131613 1 GO:0005030 neurotrophin receptor activity 8/2568 51/18639 0.156862745098039 1.13853765805388 0.405251217019487 1 GO:0000182 rDNA binding 2/2568 10/18639 0.2 1.45163551401869 0.410058490298918 1 GO:0004382 GDP phosphatase activity 2/2568 10/18639 0.2 1.45163551401869 0.410058490298918 1 GO:0005031 tumor necrosis factor receptor activity 2/2568 10/18639 0.2 1.45163551401869 0.410058490298918 1 GO:0005345 purine nucleobase transmembrane transporter activity 2/2568 10/18639 0.2 1.45163551401869 0.410058490298918 1 GO:0015187 glycine transmembrane transporter activity 2/2568 10/18639 0.2 1.45163551401869 0.410058490298918 1 GO:0015203 polyamine transmembrane transporter activity 2/2568 10/18639 0.2 1.45163551401869 0.410058490298918 1 GO:0015924 mannosyl-oligosaccharide mannosidase activity 2/2568 10/18639 0.2 1.45163551401869 0.410058490298918 1 GO:0016175 superoxide-generating NAD(P)H oxidase activity 2/2568 10/18639 0.2 1.45163551401869 0.410058490298918 1 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 2/2568 10/18639 0.2 1.45163551401869 0.410058490298918 1 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 2/2568 10/18639 0.2 1.45163551401869 0.410058490298918 1 GO:0019531 oxalate transmembrane transporter activity 2/2568 10/18639 0.2 1.45163551401869 0.410058490298918 1 GO:0030957 Tat protein binding 2/2568 10/18639 0.2 1.45163551401869 0.410058490298918 1 GO:0031419 cobalamin binding 2/2568 10/18639 0.2 1.45163551401869 0.410058490298918 1 GO:0031996 thioesterase binding 2/2568 10/18639 0.2 1.45163551401869 0.410058490298918 1 GO:0035256 G protein-coupled glutamate receptor binding 2/2568 10/18639 0.2 1.45163551401869 0.410058490298918 1 GO:0035374 chondroitin sulfate binding 2/2568 10/18639 0.2 1.45163551401869 0.410058490298918 1 GO:0043422 protein kinase B binding 2/2568 10/18639 0.2 1.45163551401869 0.410058490298918 1 GO:0070097 delta-catenin binding 2/2568 10/18639 0.2 1.45163551401869 0.410058490298918 1 GO:0070739 protein-glutamic acid ligase activity 2/2568 10/18639 0.2 1.45163551401869 0.410058490298918 1 GO:0070740 tubulin-glutamic acid ligase activity 2/2568 10/18639 0.2 1.45163551401869 0.410058490298918 1 GO:0098505 G-rich strand telomeric DNA binding 2/2568 10/18639 0.2 1.45163551401869 0.410058490298918 1 GO:0099122 RNA polymerase II C-terminal domain binding 2/2568 10/18639 0.2 1.45163551401869 0.410058490298918 1 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 3/2568 17/18639 0.176470588235294 1.28085486531061 0.421650187978592 1 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 3/2568 17/18639 0.176470588235294 1.28085486531061 0.421650187978592 1 GO:0008429 phosphatidylethanolamine binding 3/2568 17/18639 0.176470588235294 1.28085486531061 0.421650187978592 1 GO:0015278 intracellularly gated calcium channel activity 3/2568 17/18639 0.176470588235294 1.28085486531061 0.421650187978592 1 GO:0017110 nucleoside diphosphate phosphatase activity 3/2568 17/18639 0.176470588235294 1.28085486531061 0.421650187978592 1 GO:0019198 transmembrane receptor protein phosphatase activity 3/2568 17/18639 0.176470588235294 1.28085486531061 0.421650187978592 1 GO:0032183 SUMO binding 3/2568 17/18639 0.176470588235294 1.28085486531061 0.421650187978592 1 GO:0070492 oligosaccharide binding 3/2568 17/18639 0.176470588235294 1.28085486531061 0.421650187978592 1 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 4/2568 24/18639 0.166666666666667 1.20969626168224 0.425980899918047 1 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 4/2568 24/18639 0.166666666666667 1.20969626168224 0.425980899918047 1 GO:0005315 phosphate transmembrane transporter activity 4/2568 24/18639 0.166666666666667 1.20969626168224 0.425980899918047 1 GO:0030552 cAMP binding 4/2568 24/18639 0.166666666666667 1.20969626168224 0.425980899918047 1 GO:0035035 histone acetyltransferase binding 4/2568 24/18639 0.166666666666667 1.20969626168224 0.425980899918047 1 GO:0045309 protein phosphorylated amino acid binding 9/2568 59/18639 0.152542372881356 1.10717962933629 0.426547647482969 1 GO:0070888 E-box binding 9/2568 59/18639 0.152542372881356 1.10717962933629 0.426547647482969 1 GO:0015291 secondary active transmembrane transporter activity 41/2568 287/18639 0.142857142857143 1.03688251001335 0.426607809415102 1 GO:0005164 tumor necrosis factor receptor binding 5/2568 31/18639 0.161290322580645 1.17067380162798 0.427684910156204 1 GO:0016878 acid-thiol ligase activity 5/2568 31/18639 0.161290322580645 1.17067380162798 0.427684910156204 1 GO:0017147 Wnt-protein binding 5/2568 31/18639 0.161290322580645 1.17067380162798 0.427684910156204 1 GO:0070325 lipoprotein particle receptor binding 5/2568 31/18639 0.161290322580645 1.17067380162798 0.427684910156204 1 GO:0140030 modification-dependent protein binding 25/2568 173/18639 0.144508670520231 1.04886959105397 0.431324203625042 1 GO:0004620 phospholipase activity 16/2568 109/18639 0.146788990825688 1.06542056074766 0.433619184612697 1 GO:0030695 GTPase regulator activity 69/2568 489/18639 0.141104294478528 1.02416002522791 0.43455771006319 1 GO:0004197 cysteine-type endopeptidase activity 13/2568 88/18639 0.147727272727273 1.07223077740017 0.439123816332635 1 GO:0015101 organic cation transmembrane transporter activity 12/2568 81/18639 0.148148148148148 1.07528556593977 0.441062436896678 1 GO:0060589 nucleoside-triphosphatase regulator activity 69/2568 490/18639 0.140816326530612 1.02206990272745 0.44180203327805 1 GO:0016500 protein-hormone receptor activity 10/2568 67/18639 0.149253731343284 1.08331008508858 0.445116043490262 1 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 9/2568 60/18639 0.15 1.08872663551402 0.447236866548912 1 GO:0005003 ephrin receptor activity 8/2568 53/18639 0.150943396226415 1.0955739728443 0.449421725167694 1 GO:0005005 transmembrane-ephrin receptor activity 8/2568 53/18639 0.150943396226415 1.0955739728443 0.449421725167694 1 GO:0051018 protein kinase A binding 8/2568 53/18639 0.150943396226415 1.0955739728443 0.449421725167694 1 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 7/2568 46/18639 0.152173913043478 1.10450528240553 0.451666454655806 1 GO:0000217 DNA secondary structure binding 6/2568 39/18639 0.153846153846154 1.1166427030913 0.453956023325005 1 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 13/2568 89/18639 0.146067415730337 1.06018324057545 0.45610480151158 1 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 13/2568 89/18639 0.146067415730337 1.06018324057545 0.45610480151158 1 GO:0015106 bicarbonate transmembrane transporter activity 5/2568 32/18639 0.15625 1.1340902453271 0.456248878092747 1 GO:0016247 channel regulator activity 24/2568 168/18639 0.142857142857143 1.03688251001335 0.457759377412274 1 GO:0000030 mannosyltransferase activity 4/2568 25/18639 0.16 1.16130841121495 0.458431814634122 1 GO:0004709 MAP kinase kinase kinase activity 4/2568 25/18639 0.16 1.16130841121495 0.458431814634122 1 GO:0015296 monoatomic anion:monoatomic cation symporter activity 4/2568 25/18639 0.16 1.16130841121495 0.458431814634122 1 GO:0015645 fatty acid ligase activity 4/2568 25/18639 0.16 1.16130841121495 0.458431814634122 1 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 4/2568 25/18639 0.16 1.16130841121495 0.458431814634122 1 GO:0120515 fatty acid-CoA ligase activity 4/2568 25/18639 0.16 1.16130841121495 0.458431814634122 1 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 2/2568 11/18639 0.181818181818182 1.3196686491079 0.460069663981798 1 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 2/2568 11/18639 0.181818181818182 1.3196686491079 0.460069663981798 1 GO:0003953 NAD+ nucleosidase activity 2/2568 11/18639 0.181818181818182 1.3196686491079 0.460069663981798 1 GO:0004016 adenylate cyclase activity 2/2568 11/18639 0.181818181818182 1.3196686491079 0.460069663981798 1 GO:0004143 ATP-dependent diacylglycerol kinase activity 2/2568 11/18639 0.181818181818182 1.3196686491079 0.460069663981798 1 GO:0008172 S-methyltransferase activity 2/2568 11/18639 0.181818181818182 1.3196686491079 0.460069663981798 1 GO:0008526 phosphatidylinositol transfer activity 2/2568 11/18639 0.181818181818182 1.3196686491079 0.460069663981798 1 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 2/2568 11/18639 0.181818181818182 1.3196686491079 0.460069663981798 1 GO:0015173 aromatic amino acid transmembrane transporter activity 2/2568 11/18639 0.181818181818182 1.3196686491079 0.460069663981798 1 GO:0015205 nucleobase transmembrane transporter activity 2/2568 11/18639 0.181818181818182 1.3196686491079 0.460069663981798 1 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 2/2568 11/18639 0.181818181818182 1.3196686491079 0.460069663981798 1 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 2/2568 11/18639 0.181818181818182 1.3196686491079 0.460069663981798 1 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 2/2568 11/18639 0.181818181818182 1.3196686491079 0.460069663981798 1 GO:0019203 carbohydrate phosphatase activity 2/2568 11/18639 0.181818181818182 1.3196686491079 0.460069663981798 1 GO:0019215 intermediate filament binding 2/2568 11/18639 0.181818181818182 1.3196686491079 0.460069663981798 1 GO:0032404 mismatch repair complex binding 2/2568 11/18639 0.181818181818182 1.3196686491079 0.460069663981798 1 GO:0032794 GTPase activating protein binding 2/2568 11/18639 0.181818181818182 1.3196686491079 0.460069663981798 1 GO:0034713 type I transforming growth factor beta receptor binding 2/2568 11/18639 0.181818181818182 1.3196686491079 0.460069663981798 1 GO:0048185 activin binding 2/2568 11/18639 0.181818181818182 1.3196686491079 0.460069663981798 1 GO:0070990 snRNP binding 2/2568 11/18639 0.181818181818182 1.3196686491079 0.460069663981798 1 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 2/2568 11/18639 0.181818181818182 1.3196686491079 0.460069663981798 1 GO:0140537 transcription regulator activator activity 2/2568 11/18639 0.181818181818182 1.3196686491079 0.460069663981798 1 GO:0015172 acidic amino acid transmembrane transporter activity 3/2568 18/18639 0.166666666666667 1.20969626168224 0.460160829964979 1 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 3/2568 18/18639 0.166666666666667 1.20969626168224 0.460160829964979 1 GO:0030228 lipoprotein particle receptor activity 3/2568 18/18639 0.166666666666667 1.20969626168224 0.460160829964979 1 GO:1901611 phosphatidylglycerol binding 3/2568 18/18639 0.166666666666667 1.20969626168224 0.460160829964979 1 GO:0008514 organic anion transmembrane transporter activity 38/2568 269/18639 0.141263940520446 1.02531876454852 0.460611313180713 1 GO:0003925 G protein activity 8/2568 54/18639 0.148148148148148 1.07528556593977 0.471323324072071 1 GO:0140793 histone H2AXY142 phosphatase activity 13/2568 90/18639 0.144444444444444 1.04840342679128 0.473028781177916 1 GO:0061749 forked DNA-dependent helicase activity 7/2568 47/18639 0.148936170212766 1.08100517001392 0.475171940827486 1 GO:1990518 single-stranded 3'-5' DNA helicase activity 7/2568 47/18639 0.148936170212766 1.08100517001392 0.475171940827486 1 GO:0141108 transporter regulator activity 24/2568 170/18639 0.141176470588235 1.02468389224849 0.4824165703316 1 GO:0016279 protein-lysine N-methyltransferase activity 10/2568 69/18639 0.144927536231884 1.05190979276717 0.483948433453843 1 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 5/2568 33/18639 0.151515151515152 1.09972387425658 0.484396828653528 1 GO:0004725 protein tyrosine phosphatase activity 14/2568 98/18639 0.142857142857143 1.03688251001335 0.486094512096441 1 GO:0008170 N-methyltransferase activity 14/2568 98/18639 0.142857142857143 1.03688251001335 0.486094512096441 1 GO:0015179 L-amino acid transmembrane transporter activity 9/2568 62/18639 0.145161290322581 1.05360642146518 0.488248827416584 1 GO:0043548 phosphatidylinositol 3-kinase binding 4/2568 26/18639 0.153846153846154 1.1166427030913 0.490228335165649 1 GO:0051117 ATPase binding 12/2568 84/18639 0.142857142857143 1.03688251001335 0.493925094590339 1 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 3/2568 19/18639 0.157894736842105 1.14602803738318 0.497517455613445 1 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 3/2568 19/18639 0.157894736842105 1.14602803738318 0.497517455613445 1 GO:0140036 ubiquitin-modified protein reader activity 3/2568 19/18639 0.157894736842105 1.14602803738318 0.497517455613445 1 GO:1990380 K48-linked deubiquitinase activity 3/2568 19/18639 0.157894736842105 1.14602803738318 0.497517455613445 1 GO:0009378 four-way junction helicase activity 7/2568 48/18639 0.145833333333333 1.05848422897196 0.498405606886919 1 GO:0032266 phosphatidylinositol-3-phosphate binding 7/2568 48/18639 0.145833333333333 1.05848422897196 0.498405606886919 1 GO:0036121 double-stranded DNA helicase activity 7/2568 48/18639 0.145833333333333 1.05848422897196 0.498405606886919 1 GO:0043138 3'-5' DNA helicase activity 7/2568 48/18639 0.145833333333333 1.05848422897196 0.498405606886919 1 GO:0016278 lysine N-methyltransferase activity 10/2568 70/18639 0.142857142857143 1.03688251001335 0.503141337539017 1 GO:0001530 lipopolysaccharide binding 6/2568 41/18639 0.146341463414634 1.06217232733075 0.504619602929007 1 GO:0016877 ligase activity, forming carbon-sulfur bonds 6/2568 41/18639 0.146341463414634 1.06217232733075 0.504619602929007 1 GO:0003697 single-stranded DNA binding 17/2568 121/18639 0.140495867768595 1.01974395612883 0.505348510255345 1 GO:0043178 alcohol binding 13/2568 92/18639 0.141304347826087 1.02561204794799 0.506590413316736 1 GO:0003995 acyl-CoA dehydrogenase activity 2/2568 12/18639 0.166666666666667 1.20969626168224 0.507504032613098 1 GO:0004300 enoyl-CoA hydratase activity 2/2568 12/18639 0.166666666666667 1.20969626168224 0.507504032613098 1 GO:0004875 complement receptor activity 2/2568 12/18639 0.166666666666667 1.20969626168224 0.507504032613098 1 GO:0005049 nuclear export signal receptor activity 2/2568 12/18639 0.166666666666667 1.20969626168224 0.507504032613098 1 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 2/2568 12/18639 0.166666666666667 1.20969626168224 0.507504032613098 1 GO:0008504 monoamine transmembrane transporter activity 2/2568 12/18639 0.166666666666667 1.20969626168224 0.507504032613098 1 GO:0015166 polyol transmembrane transporter activity 2/2568 12/18639 0.166666666666667 1.20969626168224 0.507504032613098 1 GO:0015269 calcium-activated potassium channel activity 2/2568 12/18639 0.166666666666667 1.20969626168224 0.507504032613098 1 GO:0016801 hydrolase activity, acting on ether bonds 2/2568 12/18639 0.166666666666667 1.20969626168224 0.507504032613098 1 GO:0016803 ether hydrolase activity 2/2568 12/18639 0.166666666666667 1.20969626168224 0.507504032613098 1 GO:0035014 phosphatidylinositol 3-kinase regulator activity 2/2568 12/18639 0.166666666666667 1.20969626168224 0.507504032613098 1 GO:0043047 single-stranded telomeric DNA binding 2/2568 12/18639 0.166666666666667 1.20969626168224 0.507504032613098 1 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 2/2568 12/18639 0.166666666666667 1.20969626168224 0.507504032613098 1 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 2/2568 12/18639 0.166666666666667 1.20969626168224 0.507504032613098 1 GO:0070008 serine-type exopeptidase activity 2/2568 12/18639 0.166666666666667 1.20969626168224 0.507504032613098 1 GO:0070679 inositol 1,4,5 trisphosphate binding 2/2568 12/18639 0.166666666666667 1.20969626168224 0.507504032613098 1 GO:0097371 MDM2/MDM4 family protein binding 2/2568 12/18639 0.166666666666667 1.20969626168224 0.507504032613098 1 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 2/2568 12/18639 0.166666666666667 1.20969626168224 0.507504032613098 1 GO:0140829 bicarbonate:monoatomic anion antiporter activity 2/2568 12/18639 0.166666666666667 1.20969626168224 0.507504032613098 1 GO:0140900 chloride:bicarbonate antiporter activity 2/2568 12/18639 0.166666666666667 1.20969626168224 0.507504032613098 1 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 2/2568 12/18639 0.166666666666667 1.20969626168224 0.507504032613098 1 GO:0008376 acetylgalactosaminyltransferase activity 5/2568 34/18639 0.147058823529412 1.06737905442551 0.512015023447826 1 GO:0051427 hormone receptor binding 5/2568 34/18639 0.147058823529412 1.06737905442551 0.512015023447826 1 GO:0001671 ATPase activator activity 4/2568 27/18639 0.148148148148148 1.07528556593977 0.521220842291974 1 GO:0005044 scavenger receptor activity 4/2568 27/18639 0.148148148148148 1.07528556593977 0.521220842291974 1 GO:0016405 CoA-ligase activity 4/2568 27/18639 0.148148148148148 1.07528556593977 0.521220842291974 1 GO:0023026 MHC class II protein complex binding 4/2568 27/18639 0.148148148148148 1.07528556593977 0.521220842291974 1 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 4/2568 27/18639 0.148148148148148 1.07528556593977 0.521220842291974 1 GO:0060590 ATPase regulator activity 7/2568 49/18639 0.142857142857143 1.03688251001335 0.521300597054678 1 GO:0019903 protein phosphatase binding 20/2568 144/18639 0.138888888888889 1.00808021806854 0.521324035566506 1 GO:0140299 molecular sensor activity 10/2568 71/18639 0.140845070422535 1.02227853099908 0.522131944227533 1 GO:0001221 transcription coregulator binding 16/2568 115/18639 0.139130434782609 1.00983340105648 0.524274837134454 1 GO:0050660 flavin adenine dinucleotide binding 12/2568 86/18639 0.13953488372093 1.01276896326885 0.528535555848395 1 GO:0043175 RNA polymerase core enzyme binding 6/2568 42/18639 0.142857142857143 1.03688251001335 0.529312843146699 1 GO:0016298 lipase activity 18/2568 130/18639 0.138461538461538 1.00497843278217 0.529671761535214 1 GO:0140297 DNA-binding transcription factor binding 67/2568 488/18639 0.137295081967213 0.996512084418569 0.532916673261042 1 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 3/2568 20/18639 0.15 1.08872663551402 0.533517493115614 1 GO:0030742 GTP-dependent protein binding 3/2568 20/18639 0.15 1.08872663551402 0.533517493115614 1 GO:0031418 L-ascorbic acid binding 3/2568 20/18639 0.15 1.08872663551402 0.533517493115614 1 GO:0140939 histone H4 methyltransferase activity 3/2568 20/18639 0.15 1.08872663551402 0.533517493115614 1 GO:0043015 gamma-tubulin binding 5/2568 35/18639 0.142857142857143 1.03688251001335 0.539003712420798 1 GO:0061631 ubiquitin conjugating enzyme activity 5/2568 35/18639 0.142857142857143 1.03688251001335 0.539003712420798 1 GO:0140566 histone reader activity 5/2568 35/18639 0.142857142857143 1.03688251001335 0.539003712420798 1 GO:0099106 ion channel regulator activity 22/2568 160/18639 0.1375 0.997999415887851 0.539075587788866 1 GO:0038024 cargo receptor activity 9/2568 65/18639 0.138461538461538 1.00497843278217 0.548128317620384 1 GO:0005096 GTPase activator activity 37/2568 271/18639 0.136531365313653 0.990968893333793 0.550964206081348 1 GO:0002161 aminoacyl-tRNA editing activity 2/2568 13/18639 0.153846153846154 1.1166427030913 0.55212216140487 1 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 2/2568 13/18639 0.153846153846154 1.1166427030913 0.55212216140487 1 GO:0005338 nucleotide-sugar transmembrane transporter activity 2/2568 13/18639 0.153846153846154 1.1166427030913 0.55212216140487 1 GO:0005542 folic acid binding 2/2568 13/18639 0.153846153846154 1.1166427030913 0.55212216140487 1 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 2/2568 13/18639 0.153846153846154 1.1166427030913 0.55212216140487 1 GO:0039706 co-receptor binding 2/2568 13/18639 0.153846153846154 1.1166427030913 0.55212216140487 1 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 2/2568 13/18639 0.153846153846154 1.1166427030913 0.55212216140487 1 GO:0046975 histone H3K36 methyltransferase activity 2/2568 13/18639 0.153846153846154 1.1166427030913 0.55212216140487 1 GO:0051011 microtubule minus-end binding 2/2568 13/18639 0.153846153846154 1.1166427030913 0.55212216140487 1 GO:0071714 icosanoid transmembrane transporter activity 2/2568 13/18639 0.153846153846154 1.1166427030913 0.55212216140487 1 GO:0089720 caspase binding 2/2568 13/18639 0.153846153846154 1.1166427030913 0.55212216140487 1 GO:0097157 pre-mRNA intronic binding 2/2568 13/18639 0.153846153846154 1.1166427030913 0.55212216140487 1 GO:1901338 catecholamine binding 2/2568 13/18639 0.153846153846154 1.1166427030913 0.55212216140487 1 GO:0019208 phosphatase regulator activity 16/2568 117/18639 0.136752136752137 0.992571291636712 0.553698385883247 1 GO:0008276 protein methyltransferase activity 13/2568 95/18639 0.136842105263158 0.993224299065421 0.555816300293428 1 GO:0061135 endopeptidase regulator activity 25/2568 184/18639 0.135869565217391 0.98616543071922 0.562748494263301 1 GO:0016830 carbon-carbon lyase activity 7/2568 51/18639 0.137254901960784 0.996220450797141 0.565837296413697 1 GO:0008373 sialyltransferase activity 3/2568 21/18639 0.142857142857143 1.03688251001335 0.5680070290174 1 GO:0009975 cyclase activity 3/2568 21/18639 0.142857142857143 1.03688251001335 0.5680070290174 1 GO:0010314 phosphatidylinositol-5-phosphate binding 3/2568 21/18639 0.142857142857143 1.03688251001335 0.5680070290174 1 GO:0051428 peptide hormone receptor binding 3/2568 21/18639 0.142857142857143 1.03688251001335 0.5680070290174 1 GO:0070182 DNA polymerase binding 3/2568 21/18639 0.142857142857143 1.03688251001335 0.5680070290174 1 GO:1904047 S-adenosyl-L-methionine binding 3/2568 21/18639 0.142857142857143 1.03688251001335 0.5680070290174 1 GO:1901981 phosphatidylinositol phosphate binding 25/2568 185/18639 0.135135135135135 0.980834806769386 0.574296120720243 1 GO:0015459 potassium channel regulator activity 8/2568 59/18639 0.135593220338983 0.984159670521147 0.576706120235006 1 GO:0003678 DNA helicase activity 10/2568 74/18639 0.135135135135135 0.980834806769386 0.577533091136636 1 GO:0035064 methylated histone binding 10/2568 74/18639 0.135135135135135 0.980834806769386 0.577533091136636 1 GO:0000287 magnesium ion binding 31/2568 230/18639 0.134782608695652 0.978276107273466 0.581994509550091 1 GO:0016757 glycosyltransferase activity 36/2568 267/18639 0.134831460674157 0.978630683608107 0.583129766537916 1 GO:0030159 signaling receptor complex adaptor activity 7/2568 52/18639 0.134615384615385 0.977062365204889 0.587375674412833 1 GO:0023023 MHC protein complex binding 5/2568 37/18639 0.135135135135135 0.980834806769386 0.590762076309746 1 GO:0030551 cyclic nucleotide binding 5/2568 37/18639 0.135135135135135 0.980834806769386 0.590762076309746 1 GO:0004065 arylsulfatase activity 2/2568 14/18639 0.142857142857143 1.03688251001335 0.593799444634165 1 GO:0005161 platelet-derived growth factor receptor binding 2/2568 14/18639 0.142857142857143 1.03688251001335 0.593799444634165 1 GO:0008494 translation activator activity 2/2568 14/18639 0.142857142857143 1.03688251001335 0.593799444634165 1 GO:0015926 glucosidase activity 2/2568 14/18639 0.142857142857143 1.03688251001335 0.593799444634165 1 GO:0019992 diacylglycerol binding 2/2568 14/18639 0.142857142857143 1.03688251001335 0.593799444634165 1 GO:0034236 protein kinase A catalytic subunit binding 2/2568 14/18639 0.142857142857143 1.03688251001335 0.593799444634165 1 GO:0044548 S100 protein binding 2/2568 14/18639 0.142857142857143 1.03688251001335 0.593799444634165 1 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 2/2568 14/18639 0.142857142857143 1.03688251001335 0.593799444634165 1 GO:0098847 sequence-specific single stranded DNA binding 2/2568 14/18639 0.142857142857143 1.03688251001335 0.593799444634165 1 GO:1901474 azole transmembrane transporter activity 2/2568 14/18639 0.142857142857143 1.03688251001335 0.593799444634165 1 GO:1901612 cardiolipin binding 2/2568 14/18639 0.142857142857143 1.03688251001335 0.593799444634165 1 GO:1990825 sequence-specific mRNA binding 2/2568 14/18639 0.142857142857143 1.03688251001335 0.593799444634165 1 GO:0015103 inorganic anion transmembrane transporter activity 22/2568 165/18639 0.133333333333333 0.967757009345794 0.600429779145974 1 GO:0004407 histone deacetylase activity 3/2568 22/18639 0.136363636363636 0.989751486830926 0.600875251949534 1 GO:0008093 cytoskeletal anchor activity 3/2568 22/18639 0.136363636363636 0.989751486830926 0.600875251949534 1 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 3/2568 22/18639 0.136363636363636 0.989751486830926 0.600875251949534 1 GO:0031683 G-protein beta/gamma-subunit complex binding 3/2568 22/18639 0.136363636363636 0.989751486830926 0.600875251949534 1 GO:0033558 protein lysine deacetylase activity 3/2568 22/18639 0.136363636363636 0.989751486830926 0.600875251949534 1 GO:0005548 phospholipid transporter activity 9/2568 68/18639 0.132352941176471 0.960641148982958 0.605059678968121 1 GO:0016769 transferase activity, transferring nitrogenous groups 4/2568 30/18639 0.133333333333333 0.967757009345794 0.608236901938279 1 GO:0031210 phosphatidylcholine binding 4/2568 30/18639 0.133333333333333 0.967757009345794 0.608236901938279 1 GO:0048019 receptor antagonist activity 4/2568 30/18639 0.133333333333333 0.967757009345794 0.608236901938279 1 GO:0051721 protein phosphatase 2A binding 4/2568 30/18639 0.133333333333333 0.967757009345794 0.608236901938279 1 GO:0046943 carboxylic acid transmembrane transporter activity 25/2568 188/18639 0.132978723404255 0.965183187512428 0.608263972263855 1 GO:0017046 peptide hormone binding 7/2568 53/18639 0.132075471698113 0.958627226238759 0.608368666689267 1 GO:0017022 myosin binding 10/2568 76/18639 0.131578947368421 0.955023364485981 0.612847994740919 1 GO:0140034 methylation-dependent protein binding 10/2568 76/18639 0.131578947368421 0.955023364485981 0.612847994740919 1 GO:0042162 telomeric DNA binding 5/2568 38/18639 0.131578947368421 0.955023364485981 0.615399346070252 1 GO:0015026 coreceptor activity 8/2568 61/18639 0.131147540983607 0.951892140340126 0.616066502615358 1 GO:0005342 organic acid transmembrane transporter activity 25/2568 189/18639 0.132275132275132 0.96007639816051 0.619335556763594 1 GO:0030276 clathrin binding 6/2568 46/18639 0.130434782608696 0.946718813490451 0.622250960662853 1 GO:0019888 protein phosphatase regulator activity 14/2568 107/18639 0.130841121495327 0.949668093283256 0.625142986364332 1 GO:0015485 cholesterol binding 7/2568 54/18639 0.12962962962963 0.9408748701973 0.628779675164169 1 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 7/2568 54/18639 0.12962962962963 0.9408748701973 0.628779675164169 1 GO:0004022 alcohol dehydrogenase (NAD+) activity 3/2568 23/18639 0.130434782608696 0.946718813490451 0.632048952650896 1 GO:0005158 insulin receptor binding 3/2568 23/18639 0.130434782608696 0.946718813490451 0.632048952650896 1 GO:0140103 catalytic activity, acting on a glycoprotein 3/2568 23/18639 0.130434782608696 0.946718813490451 0.632048952650896 1 GO:0004467 long-chain fatty acid-CoA ligase activity 2/2568 15/18639 0.133333333333333 0.967757009345794 0.632499029060844 1 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 2/2568 15/18639 0.133333333333333 0.967757009345794 0.632499029060844 1 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 2/2568 15/18639 0.133333333333333 0.967757009345794 0.632499029060844 1 GO:0005041 low-density lipoprotein particle receptor activity 2/2568 15/18639 0.133333333333333 0.967757009345794 0.632499029060844 1 GO:0005402 carbohydrate:monoatomic cation symporter activity 2/2568 15/18639 0.133333333333333 0.967757009345794 0.632499029060844 1 GO:0005523 tropomyosin binding 2/2568 15/18639 0.133333333333333 0.967757009345794 0.632499029060844 1 GO:0015116 sulfate transmembrane transporter activity 2/2568 15/18639 0.133333333333333 0.967757009345794 0.632499029060844 1 GO:0015929 hexosaminidase activity 2/2568 15/18639 0.133333333333333 0.967757009345794 0.632499029060844 1 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 2/2568 15/18639 0.133333333333333 0.967757009345794 0.632499029060844 1 GO:0034483 heparan sulfate sulfotransferase activity 2/2568 15/18639 0.133333333333333 0.967757009345794 0.632499029060844 1 GO:0042809 nuclear vitamin D receptor binding 2/2568 15/18639 0.133333333333333 0.967757009345794 0.632499029060844 1 GO:0140161 monocarboxylate:sodium symporter activity 2/2568 15/18639 0.133333333333333 0.967757009345794 0.632499029060844 1 GO:0140776 protein-containing complex destabilizing activity 2/2568 15/18639 0.133333333333333 0.967757009345794 0.632499029060844 1 GO:0016411 acylglycerol O-acyltransferase activity 4/2568 31/18639 0.129032258064516 0.936539041302382 0.634985345165254 1 GO:0047499 calcium-independent phospholipase A2 activity 4/2568 31/18639 0.129032258064516 0.936539041302382 0.634985345165254 1 GO:0016791 phosphatase activity 36/2568 273/18639 0.131868131868132 0.957122316935401 0.638935740270701 1 GO:0001784 phosphotyrosine residue binding 6/2568 47/18639 0.127659574468085 0.926575860011931 0.643774719663151 1 GO:0005507 copper ion binding 8/2568 63/18639 0.126984126984127 0.92167334223409 0.653406857555702 1 GO:0022884 macromolecule transmembrane transporter activity 4/2568 32/18639 0.125 0.907272196261682 0.660519126175612 1 GO:0070717 poly-purine tract binding 4/2568 32/18639 0.125 0.907272196261682 0.660519126175612 1 GO:0140142 nucleocytoplasmic carrier activity 4/2568 32/18639 0.125 0.907272196261682 0.660519126175612 1 GO:0004713 protein tyrosine kinase activity 18/2568 140/18639 0.128571428571429 0.933194259012016 0.66128942089038 1 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 3/2568 24/18639 0.125 0.907272196261682 0.661487245898446 1 GO:0070840 dynein complex binding 3/2568 24/18639 0.125 0.907272196261682 0.661487245898446 1 GO:0004177 aminopeptidase activity 5/2568 40/18639 0.125 0.907272196261682 0.66195062446885 1 GO:0030331 nuclear estrogen receptor binding 5/2568 40/18639 0.125 0.907272196261682 0.66195062446885 1 GO:0032451 demethylase activity 5/2568 40/18639 0.125 0.907272196261682 0.66195062446885 1 GO:0050997 quaternary ammonium group binding 5/2568 40/18639 0.125 0.907272196261682 0.66195062446885 1 GO:0071855 neuropeptide receptor binding 5/2568 40/18639 0.125 0.907272196261682 0.66195062446885 1 GO:0140693 molecular condensate scaffold activity 6/2568 48/18639 0.125 0.907272196261682 0.664541735774041 1 GO:0000062 fatty-acyl-CoA binding 2/2568 16/18639 0.125 0.907272196261682 0.66825001435192 1 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 2/2568 16/18639 0.125 0.907272196261682 0.66825001435192 1 GO:0004708 MAP kinase kinase activity 2/2568 16/18639 0.125 0.907272196261682 0.66825001435192 1 GO:0005324 long-chain fatty acid transmembrane transporter activity 2/2568 16/18639 0.125 0.907272196261682 0.66825001435192 1 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 2/2568 16/18639 0.125 0.907272196261682 0.66825001435192 1 GO:0022841 potassium ion leak channel activity 2/2568 16/18639 0.125 0.907272196261682 0.66825001435192 1 GO:0034450 ubiquitin-ubiquitin ligase activity 2/2568 16/18639 0.125 0.907272196261682 0.66825001435192 1 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 2/2568 16/18639 0.125 0.907272196261682 0.66825001435192 1 GO:0140327 flippase activity 2/2568 16/18639 0.125 0.907272196261682 0.66825001435192 1 GO:0008509 monoatomic anion transmembrane transporter activity 19/2568 149/18639 0.12751677852349 0.92553942168977 0.677889043191882 1 GO:0051020 GTPase binding 41/2568 315/18639 0.13015873015873 0.944715175789942 0.678294243829639 1 GO:0008234 cysteine-type peptidase activity 24/2568 187/18639 0.128342245989305 0.931530811134989 0.678312430294366 1 GO:0019887 protein kinase regulator activity 33/2568 255/18639 0.129411764705882 0.939293567894448 0.678978568630366 1 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 5/2568 41/18639 0.121951219512195 0.885143606108958 0.683802155238272 1 GO:0008227 G protein-coupled amine receptor activity 5/2568 41/18639 0.121951219512195 0.885143606108958 0.683802155238272 1 GO:0140318 protein transporter activity 5/2568 41/18639 0.121951219512195 0.885143606108958 0.683802155238272 1 GO:0015271 outward rectifier potassium channel activity 3/2568 25/18639 0.12 0.870981308411215 0.689176622889036 1 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 3/2568 25/18639 0.12 0.870981308411215 0.689176622889036 1 GO:0017025 TBP-class protein binding 3/2568 25/18639 0.12 0.870981308411215 0.689176622889036 1 GO:0019211 phosphatase activator activity 3/2568 25/18639 0.12 0.870981308411215 0.689176622889036 1 GO:0019706 protein-cysteine S-palmitoyltransferase activity 3/2568 25/18639 0.12 0.870981308411215 0.689176622889036 1 GO:0019707 protein-cysteine S-acyltransferase activity 3/2568 25/18639 0.12 0.870981308411215 0.689176622889036 1 GO:0005200 structural constituent of cytoskeleton 14/2568 112/18639 0.125 0.907272196261682 0.693778255897425 1 GO:0030971 receptor tyrosine kinase binding 10/2568 81/18639 0.123456790123457 0.89607130494981 0.69409393023631 1 GO:0032182 ubiquitin-like protein binding 15/2568 120/18639 0.125 0.907272196261682 0.697441992585959 1 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 2/2568 17/18639 0.117647058823529 0.853903243540407 0.701129991201697 1 GO:0005092 GDP-dissociation inhibitor activity 2/2568 17/18639 0.117647058823529 0.853903243540407 0.701129991201697 1 GO:0008484 sulfuric ester hydrolase activity 2/2568 17/18639 0.117647058823529 0.853903243540407 0.701129991201697 1 GO:0008569 minus-end-directed microtubule motor activity 2/2568 17/18639 0.117647058823529 0.853903243540407 0.701129991201697 1 GO:0016018 cyclosporin A binding 2/2568 17/18639 0.117647058823529 0.853903243540407 0.701129991201697 1 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 2/2568 17/18639 0.117647058823529 0.853903243540407 0.701129991201697 1 GO:0038191 neuropilin binding 2/2568 17/18639 0.117647058823529 0.853903243540407 0.701129991201697 1 GO:0048038 quinone binding 2/2568 17/18639 0.117647058823529 0.853903243540407 0.701129991201697 1 GO:1901567 fatty acid derivative binding 2/2568 17/18639 0.117647058823529 0.853903243540407 0.701129991201697 1 GO:0008408 3'-5' exonuclease activity 7/2568 58/18639 0.120689655172414 0.875986948114728 0.704068378541818 1 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 4/2568 34/18639 0.117647058823529 0.853903243540407 0.70785143465771 1 GO:0052866 phosphatidylinositol phosphate phosphatase activity 4/2568 34/18639 0.117647058823529 0.853903243540407 0.70785143465771 1 GO:0008143 poly(A) binding 3/2568 26/18639 0.115384615384615 0.837482027318476 0.715126399548607 1 GO:0016922 nuclear receptor binding 17/2568 137/18639 0.124087591240876 0.900649771471451 0.716046517851158 1 GO:0004497 monooxygenase activity 13/2568 106/18639 0.122641509433962 0.89015385293599 0.716373036869562 1 GO:0008013 beta-catenin binding 13/2568 106/18639 0.122641509433962 0.89015385293599 0.716373036869562 1 GO:0008194 UDP-glycosyltransferase activity 18/2568 145/18639 0.124137931034483 0.901015146632291 0.719155989541031 1 GO:0042054 histone methyltransferase activity 8/2568 67/18639 0.119402985074627 0.866648068070861 0.721341919685096 1 GO:0016597 amino acid binding 6/2568 51/18639 0.117647058823529 0.853903243540407 0.722104029531549 1 GO:0004866 endopeptidase inhibitor activity 20/2568 161/18639 0.124223602484472 0.901636965229001 0.725269923298594 1 GO:0030414 peptidase inhibitor activity 21/2568 169/18639 0.124260355029586 0.901903721727589 0.728269024519382 1 GO:0000175 3'-5'-RNA exonuclease activity 4/2568 35/18639 0.114285714285714 0.829506008010681 0.729638237526989 1 GO:0004623 phospholipase A2 activity 4/2568 35/18639 0.114285714285714 0.829506008010681 0.729638237526989 1 GO:0016229 steroid dehydrogenase activity 4/2568 35/18639 0.114285714285714 0.829506008010681 0.729638237526989 1 GO:0035401 histone H3Y41 kinase activity 14/2568 115/18639 0.121739130434783 0.883604225924421 0.731161520568778 1 GO:0140801 histone H2AXY142 kinase activity 14/2568 115/18639 0.121739130434783 0.883604225924421 0.731161520568778 1 GO:0008525 phosphatidylcholine transporter activity 2/2568 18/18639 0.111111111111111 0.806464174454829 0.731251136356287 1 GO:0015280 ligand-gated sodium channel activity 2/2568 18/18639 0.111111111111111 0.806464174454829 0.731251136356287 1 GO:0017075 syntaxin-1 binding 2/2568 18/18639 0.111111111111111 0.806464174454829 0.731251136356287 1 GO:0017128 phospholipid scramblase activity 2/2568 18/18639 0.111111111111111 0.806464174454829 0.731251136356287 1 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 2/2568 18/18639 0.111111111111111 0.806464174454829 0.731251136356287 1 GO:0070064 proline-rich region binding 2/2568 18/18639 0.111111111111111 0.806464174454829 0.731251136356287 1 GO:0070628 proteasome binding 2/2568 18/18639 0.111111111111111 0.806464174454829 0.731251136356287 1 GO:1990381 ubiquitin-specific protease binding 2/2568 18/18639 0.111111111111111 0.806464174454829 0.731251136356287 1 GO:0030145 manganese ion binding 8/2568 68/18639 0.117647058823529 0.853903243540407 0.736846218447359 1 GO:1990841 promoter-specific chromatin binding 8/2568 68/18639 0.117647058823529 0.853903243540407 0.736846218447359 1 GO:0005385 zinc ion transmembrane transporter activity 3/2568 27/18639 0.111111111111111 0.806464174454829 0.739364594205687 1 GO:0008320 protein transmembrane transporter activity 3/2568 27/18639 0.111111111111111 0.806464174454829 0.739364594205687 1 GO:0008395 steroid hydroxylase activity 3/2568 27/18639 0.111111111111111 0.806464174454829 0.739364594205687 1 GO:0043130 ubiquitin binding 12/2568 100/18639 0.12 0.870981308411215 0.739707452658196 1 GO:0042393 histone binding 31/2568 247/18639 0.125506072874494 0.910945363048167 0.740049647117496 1 GO:0030547 signaling receptor inhibitor activity 5/2568 44/18639 0.113636363636364 0.824792905692438 0.743485211950666 1 GO:0008236 serine-type peptidase activity 24/2568 194/18639 0.123711340206186 0.897918874650737 0.746127470907953 1 GO:0016409 palmitoyltransferase activity 4/2568 36/18639 0.111111111111111 0.806464174454829 0.750183401085252 1 GO:0044390 ubiquitin-like protein conjugating enzyme binding 4/2568 36/18639 0.111111111111111 0.806464174454829 0.750183401085252 1 GO:0019905 syntaxin binding 7/2568 61/18639 0.114754098360656 0.83290562279761 0.753431638910083 1 GO:0019207 kinase regulator activity 36/2568 287/18639 0.125435540069686 0.910433423426357 0.753982973063397 1 GO:1990782 protein tyrosine kinase binding 14/2568 117/18639 0.11965811965812 0.868499880182123 0.754395043531176 1 GO:0016251 RNA polymerase II general transcription initiation factor activity 6/2568 53/18639 0.113207547169811 0.821680479633222 0.756440096632484 1 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 2/2568 19/18639 0.105263157894737 0.764018691588785 0.75874921644368 1 GO:0015245 fatty acid transmembrane transporter activity 2/2568 19/18639 0.105263157894737 0.764018691588785 0.75874921644368 1 GO:0016918 retinal binding 2/2568 19/18639 0.105263157894737 0.764018691588785 0.75874921644368 1 GO:0022840 leak channel activity 2/2568 19/18639 0.105263157894737 0.764018691588785 0.75874921644368 1 GO:0022842 narrow pore channel activity 2/2568 19/18639 0.105263157894737 0.764018691588785 0.75874921644368 1 GO:0030506 ankyrin binding 2/2568 19/18639 0.105263157894737 0.764018691588785 0.75874921644368 1 GO:0031420 alkali metal ion binding 2/2568 19/18639 0.105263157894737 0.764018691588785 0.75874921644368 1 GO:0043395 heparan sulfate proteoglycan binding 2/2568 19/18639 0.105263157894737 0.764018691588785 0.75874921644368 1 GO:0046527 glucosyltransferase activity 2/2568 19/18639 0.105263157894737 0.764018691588785 0.75874921644368 1 GO:0046624 sphingolipid transporter activity 2/2568 19/18639 0.105263157894737 0.764018691588785 0.75874921644368 1 GO:0070003 threonine-type peptidase activity 2/2568 19/18639 0.105263157894737 0.764018691588785 0.75874921644368 1 GO:0120227 acyl-CoA binding 2/2568 19/18639 0.105263157894737 0.764018691588785 0.75874921644368 1 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 44/2568 349/18639 0.126074498567335 0.915071097662212 0.761072841794932 1 GO:0019789 SUMO transferase activity 3/2568 28/18639 0.107142857142857 0.777661882510013 0.761934244669642 1 GO:0051019 mitogen-activated protein kinase binding 3/2568 28/18639 0.107142857142857 0.777661882510013 0.761934244669642 1 GO:0042562 hormone binding 11/2568 94/18639 0.117021276595745 0.849361205010937 0.763753513022491 1 GO:0005244 voltage-gated monoatomic ion channel activity 21/2568 173/18639 0.121387283236994 0.881050456485333 0.766413291095838 1 GO:0016758 hexosyltransferase activity 24/2568 197/18639 0.121827411167513 0.884244983158594 0.772244912575284 1 GO:0140463 chromatin-protein adaptor activity 6/2568 54/18639 0.111111111111111 0.806464174454829 0.772397649316023 1 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 1/2568 10/18639 0.1 0.725817757009346 0.772995052253874 1 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 1/2568 10/18639 0.1 0.725817757009346 0.772995052253874 1 GO:0004955 prostaglandin receptor activity 1/2568 10/18639 0.1 0.725817757009346 0.772995052253874 1 GO:0005337 nucleoside transmembrane transporter activity 1/2568 10/18639 0.1 0.725817757009346 0.772995052253874 1 GO:0008190 eukaryotic initiation factor 4E binding 1/2568 10/18639 0.1 0.725817757009346 0.772995052253874 1 GO:0008519 ammonium channel activity 1/2568 10/18639 0.1 0.725817757009346 0.772995052253874 1 GO:0008641 ubiquitin-like modifier activating enzyme activity 1/2568 10/18639 0.1 0.725817757009346 0.772995052253874 1 GO:0015658 branched-chain amino acid transmembrane transporter activity 1/2568 10/18639 0.1 0.725817757009346 0.772995052253874 1 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1/2568 10/18639 0.1 0.725817757009346 0.772995052253874 1 GO:0019911 structural constituent of myelin sheath 1/2568 10/18639 0.1 0.725817757009346 0.772995052253874 1 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 1/2568 10/18639 0.1 0.725817757009346 0.772995052253874 1 GO:0031434 mitogen-activated protein kinase kinase binding 1/2568 10/18639 0.1 0.725817757009346 0.772995052253874 1 GO:0031956 medium-chain fatty acid-CoA ligase activity 1/2568 10/18639 0.1 0.725817757009346 0.772995052253874 1 GO:0032356 oxidized DNA binding 1/2568 10/18639 0.1 0.725817757009346 0.772995052253874 1 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 1/2568 10/18639 0.1 0.725817757009346 0.772995052253874 1 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 1/2568 10/18639 0.1 0.725817757009346 0.772995052253874 1 GO:0042975 peroxisome proliferator activated receptor binding 1/2568 10/18639 0.1 0.725817757009346 0.772995052253874 1 GO:0043208 glycosphingolipid binding 1/2568 10/18639 0.1 0.725817757009346 0.772995052253874 1 GO:0045322 unmethylated CpG binding 1/2568 10/18639 0.1 0.725817757009346 0.772995052253874 1 GO:0050308 sugar-phosphatase activity 1/2568 10/18639 0.1 0.725817757009346 0.772995052253874 1 GO:0051378 serotonin binding 1/2568 10/18639 0.1 0.725817757009346 0.772995052253874 1 GO:0051864 histone H3K36 demethylase activity 1/2568 10/18639 0.1 0.725817757009346 0.772995052253874 1 GO:0051880 G-quadruplex DNA binding 1/2568 10/18639 0.1 0.725817757009346 0.772995052253874 1 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 1/2568 10/18639 0.1 0.725817757009346 0.772995052253874 1 GO:0140135 mechanosensitive monoatomic cation channel activity 1/2568 10/18639 0.1 0.725817757009346 0.772995052253874 1 GO:0140999 histone H3K4 trimethyltransferase activity 1/2568 10/18639 0.1 0.725817757009346 0.772995052253874 1 GO:0141109 transporter activator activity 1/2568 10/18639 0.1 0.725817757009346 0.772995052253874 1 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 1/2568 10/18639 0.1 0.725817757009346 0.772995052253874 1 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 1/2568 10/18639 0.1 0.725817757009346 0.772995052253874 1 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 1/2568 10/18639 0.1 0.725817757009346 0.772995052253874 1 GO:1990763 arrestin family protein binding 1/2568 10/18639 0.1 0.725817757009346 0.772995052253874 1 GO:0019783 ubiquitin-like protein peptidase activity 15/2568 127/18639 0.118110236220472 0.857265067333873 0.776957799259541 1 GO:0033293 monocarboxylic acid binding 9/2568 79/18639 0.113924050632911 0.826880988997989 0.77767721542517 1 GO:0046332 SMAD binding 9/2568 79/18639 0.113924050632911 0.826880988997989 0.77767721542517 1 GO:0015297 antiporter activity 16/2568 135/18639 0.118518518518519 0.860228452751817 0.777851787186729 1 GO:0005126 cytokine receptor binding 34/2568 275/18639 0.123636363636364 0.897374681393373 0.777923512087595 1 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 5/2568 46/18639 0.108695652173913 0.788932344575376 0.778392689532355 1 GO:0017171 serine hydrolase activity 24/2568 198/18639 0.121212121212121 0.879779099405268 0.780544007155069 1 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 3/2568 29/18639 0.103448275862069 0.750845955526909 0.782890158082406 1 GO:0099604 ligand-gated calcium channel activity 3/2568 29/18639 0.103448275862069 0.750845955526909 0.782890158082406 1 GO:0000339 RNA cap binding 2/2568 20/18639 0.1 0.725817757009346 0.783774963480132 1 GO:0001614 purinergic nucleotide receptor activity 2/2568 20/18639 0.1 0.725817757009346 0.783774963480132 1 GO:0001972 retinoic acid binding 2/2568 20/18639 0.1 0.725817757009346 0.783774963480132 1 GO:0005326 neurotransmitter transmembrane transporter activity 2/2568 20/18639 0.1 0.725817757009346 0.783774963480132 1 GO:0016408 C-acyltransferase activity 2/2568 20/18639 0.1 0.725817757009346 0.783774963480132 1 GO:0016502 nucleotide receptor activity 2/2568 20/18639 0.1 0.725817757009346 0.783774963480132 1 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 2/2568 20/18639 0.1 0.725817757009346 0.783774963480132 1 GO:0061608 nuclear import signal receptor activity 2/2568 20/18639 0.1 0.725817757009346 0.783774963480132 1 GO:0022832 voltage-gated channel activity 21/2568 175/18639 0.12 0.870981308411215 0.784100053743815 1 GO:0004896 cytokine receptor activity 11/2568 96/18639 0.114583333333333 0.831666179906542 0.787347397324235 1 GO:0016407 acetyltransferase activity 11/2568 96/18639 0.114583333333333 0.831666179906542 0.787347397324235 1 GO:0140313 molecular sequestering activity 6/2568 55/18639 0.109090909090909 0.791801189464741 0.78755925627249 1 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 4/2568 38/18639 0.105263157894737 0.764018691588785 0.787637533552147 1 GO:0005516 calmodulin binding 25/2568 207/18639 0.120772946859903 0.87659149397264 0.790218266685967 1 GO:0004252 serine-type endopeptidase activity 21/2568 176/18639 0.119318181818182 0.86603255097706 0.792593938587624 1 GO:0170055 lipid transmembrane transporter activity 6/2568 56/18639 0.107142857142857 0.777661882510013 0.801937818117204 1 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 3/2568 30/18639 0.1 0.725817757009346 0.802296075431754 1 GO:0033612 receptor serine/threonine kinase binding 3/2568 30/18639 0.1 0.725817757009346 0.802296075431754 1 GO:0070566 adenylyltransferase activity 3/2568 30/18639 0.1 0.725817757009346 0.802296075431754 1 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 1/2568 11/18639 0.0909090909090909 0.659834324553951 0.804287591081082 1 GO:0002162 dystroglycan binding 1/2568 11/18639 0.0909090909090909 0.659834324553951 0.804287591081082 1 GO:0004954 prostanoid receptor activity 1/2568 11/18639 0.0909090909090909 0.659834324553951 0.804287591081082 1 GO:0005225 volume-sensitive anion channel activity 1/2568 11/18639 0.0909090909090909 0.659834324553951 0.804287591081082 1 GO:0008046 axon guidance receptor activity 1/2568 11/18639 0.0909090909090909 0.659834324553951 0.804287591081082 1 GO:0008199 ferric iron binding 1/2568 11/18639 0.0909090909090909 0.659834324553951 0.804287591081082 1 GO:0008271 secondary active sulfate transmembrane transporter activity 1/2568 11/18639 0.0909090909090909 0.659834324553951 0.804287591081082 1 GO:0008503 benzodiazepine receptor activity 1/2568 11/18639 0.0909090909090909 0.659834324553951 0.804287591081082 1 GO:0016594 glycine binding 1/2568 11/18639 0.0909090909090909 0.659834324553951 0.804287591081082 1 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 1/2568 11/18639 0.0909090909090909 0.659834324553951 0.804287591081082 1 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 1/2568 11/18639 0.0909090909090909 0.659834324553951 0.804287591081082 1 GO:0019107 myristoyltransferase activity 1/2568 11/18639 0.0909090909090909 0.659834324553951 0.804287591081082 1 GO:0019206 nucleoside kinase activity 1/2568 11/18639 0.0909090909090909 0.659834324553951 0.804287591081082 1 GO:0019864 IgG binding 1/2568 11/18639 0.0909090909090909 0.659834324553951 0.804287591081082 1 GO:0031731 CCR6 chemokine receptor binding 1/2568 11/18639 0.0909090909090909 0.659834324553951 0.804287591081082 1 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 1/2568 11/18639 0.0909090909090909 0.659834324553951 0.804287591081082 1 GO:0045294 alpha-catenin binding 1/2568 11/18639 0.0909090909090909 0.659834324553951 0.804287591081082 1 GO:0047676 arachidonate-CoA ligase activity 1/2568 11/18639 0.0909090909090909 0.659834324553951 0.804287591081082 1 GO:0048407 platelet-derived growth factor binding 1/2568 11/18639 0.0909090909090909 0.659834324553951 0.804287591081082 1 GO:0050786 RAGE receptor binding 1/2568 11/18639 0.0909090909090909 0.659834324553951 0.804287591081082 1 GO:0070697 activin receptor binding 1/2568 11/18639 0.0909090909090909 0.659834324553951 0.804287591081082 1 GO:0097493 structural molecule activity conferring elasticity 1/2568 11/18639 0.0909090909090909 0.659834324553951 0.804287591081082 1 GO:0099528 G protein-coupled neurotransmitter receptor activity 1/2568 11/18639 0.0909090909090909 0.659834324553951 0.804287591081082 1 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 1/2568 11/18639 0.0909090909090909 0.659834324553951 0.804287591081082 1 GO:0043539 protein serine/threonine kinase activator activity 8/2568 73/18639 0.10958904109589 0.795416720010242 0.80534797509516 1 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 15/2568 130/18639 0.115384615384615 0.837482027318476 0.806219549646072 1 GO:0009931 calcium-dependent protein serine/threonine kinase activity 2/2568 21/18639 0.0952380952380952 0.691255006675567 0.806487377634104 1 GO:0015125 bile acid transmembrane transporter activity 2/2568 21/18639 0.0952380952380952 0.691255006675567 0.806487377634104 1 GO:0015174 basic amino acid transmembrane transporter activity 2/2568 21/18639 0.0952380952380952 0.691255006675567 0.806487377634104 1 GO:0019200 carbohydrate kinase activity 2/2568 21/18639 0.0952380952380952 0.691255006675567 0.806487377634104 1 GO:0035613 RNA stem-loop binding 2/2568 21/18639 0.0952380952380952 0.691255006675567 0.806487377634104 1 GO:0036122 BMP binding 2/2568 21/18639 0.0952380952380952 0.691255006675567 0.806487377634104 1 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 2/2568 21/18639 0.0952380952380952 0.691255006675567 0.806487377634104 1 GO:0072542 protein phosphatase activator activity 2/2568 21/18639 0.0952380952380952 0.691255006675567 0.806487377634104 1 GO:0005506 iron ion binding 18/2568 154/18639 0.116883116883117 0.848358417283651 0.806882703536119 1 GO:0005319 lipid transporter activity 21/2568 178/18639 0.117977528089888 0.856301848157093 0.808883188755404 1 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 5/2568 48/18639 0.104166666666667 0.756060163551402 0.809520603739362 1 GO:0030246 carbohydrate binding 34/2568 280/18639 0.121428571428571 0.881350133511348 0.811357675310039 1 GO:0031406 carboxylic acid binding 22/2568 187/18639 0.117647058823529 0.853903243540407 0.817363636300883 1 GO:0005184 neuropeptide hormone activity 3/2568 31/18639 0.0967741935483871 0.702404280976786 0.820222225103165 1 GO:0005452 solute:inorganic anion antiporter activity 3/2568 31/18639 0.0967741935483871 0.702404280976786 0.820222225103165 1 GO:0070273 phosphatidylinositol-4-phosphate binding 3/2568 31/18639 0.0967741935483871 0.702404280976786 0.820222225103165 1 GO:0004532 RNA exonuclease activity 4/2568 40/18639 0.1 0.725817757009346 0.820459446926139 1 GO:0015144 carbohydrate transmembrane transporter activity 4/2568 40/18639 0.1 0.725817757009346 0.820459446926139 1 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 10/2568 91/18639 0.10989010989011 0.797601930779501 0.821728613711944 1 GO:0008970 phospholipase A1 activity 2/2568 22/18639 0.0909090909090909 0.659834324553951 0.82704859020256 1 GO:0030021 extracellular matrix structural constituent conferring compression resistance 2/2568 22/18639 0.0909090909090909 0.659834324553951 0.82704859020256 1 GO:0140784 metal ion sensor activity 2/2568 22/18639 0.0909090909090909 0.659834324553951 0.82704859020256 1 GO:0005496 steroid binding 12/2568 108/18639 0.111111111111111 0.806464174454829 0.827389590985464 1 GO:0003725 double-stranded RNA binding 8/2568 75/18639 0.106666666666667 0.774205607476636 0.828633423912093 1 GO:0019003 GDP binding 8/2568 75/18639 0.106666666666667 0.774205607476636 0.828633423912093 1 GO:0000995 RNA polymerase III general transcription initiation factor activity 1/2568 12/18639 0.0833333333333333 0.604848130841122 0.831267914578171 1 GO:0004032 aldose reductase (NADPH) activity 1/2568 12/18639 0.0833333333333333 0.604848130841122 0.831267914578171 1 GO:0005025 transforming growth factor beta receptor activity, type I 1/2568 12/18639 0.0833333333333333 0.604848130841122 0.831267914578171 1 GO:0005026 transforming growth factor beta receptor activity, type II 1/2568 12/18639 0.0833333333333333 0.604848130841122 0.831267914578171 1 GO:0005165 neurotrophin receptor binding 1/2568 12/18639 0.0833333333333333 0.604848130841122 0.831267914578171 1 GO:0005247 voltage-gated chloride channel activity 1/2568 12/18639 0.0833333333333333 0.604848130841122 0.831267914578171 1 GO:0005436 sodium:phosphate symporter activity 1/2568 12/18639 0.0833333333333333 0.604848130841122 0.831267914578171 1 GO:0010853 cyclase activator activity 1/2568 12/18639 0.0833333333333333 0.604848130841122 0.831267914578171 1 GO:0015132 prostaglandin transmembrane transporter activity 1/2568 12/18639 0.0833333333333333 0.604848130841122 0.831267914578171 1 GO:0015368 calcium:monoatomic cation antiporter activity 1/2568 12/18639 0.0833333333333333 0.604848130841122 0.831267914578171 1 GO:0016361 activin receptor activity, type I 1/2568 12/18639 0.0833333333333333 0.604848130841122 0.831267914578171 1 GO:0016362 activin receptor activity, type II 1/2568 12/18639 0.0833333333333333 0.604848130841122 0.831267914578171 1 GO:0017002 activin receptor activity 1/2568 12/18639 0.0833333333333333 0.604848130841122 0.831267914578171 1 GO:0031543 peptidyl-proline dioxygenase activity 1/2568 12/18639 0.0833333333333333 0.604848130841122 0.831267914578171 1 GO:0034452 dynactin binding 1/2568 12/18639 0.0833333333333333 0.604848130841122 0.831267914578171 1 GO:0035251 UDP-glucosyltransferase activity 1/2568 12/18639 0.0833333333333333 0.604848130841122 0.831267914578171 1 GO:0035497 cAMP response element binding 1/2568 12/18639 0.0833333333333333 0.604848130841122 0.831267914578171 1 GO:0070410 co-SMAD binding 1/2568 12/18639 0.0833333333333333 0.604848130841122 0.831267914578171 1 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 1/2568 12/18639 0.0833333333333333 0.604848130841122 0.831267914578171 1 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 1/2568 12/18639 0.0833333333333333 0.604848130841122 0.831267914578171 1 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 1/2568 12/18639 0.0833333333333333 0.604848130841122 0.831267914578171 1 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 1/2568 12/18639 0.0833333333333333 0.604848130841122 0.831267914578171 1 GO:0141221 histone deacetylase activity, hydrolytic mechanism 1/2568 12/18639 0.0833333333333333 0.604848130841122 0.831267914578171 1 GO:1990247 N6-methyladenosine-containing RNA reader activity 1/2568 12/18639 0.0833333333333333 0.604848130841122 0.831267914578171 1 GO:0043177 organic acid binding 22/2568 189/18639 0.116402116402116 0.844867230381249 0.831934459033897 1 GO:0046982 protein heterodimerization activity 45/2568 369/18639 0.121951219512195 0.885143606108958 0.833057922351633 1 GO:0004812 aminoacyl-tRNA ligase activity 4/2568 41/18639 0.0975609756097561 0.708114884887167 0.835233208189692 1 GO:0016875 ligase activity, forming carbon-oxygen bonds 4/2568 41/18639 0.0975609756097561 0.708114884887167 0.835233208189692 1 GO:0017080 sodium channel regulator activity 4/2568 41/18639 0.0975609756097561 0.708114884887167 0.835233208189692 1 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 3/2568 32/18639 0.09375 0.680454147196262 0.836743235337049 1 GO:0047498 calcium-dependent phospholipase A2 activity 3/2568 32/18639 0.09375 0.680454147196262 0.836743235337049 1 GO:0051059 NF-kappaB binding 3/2568 32/18639 0.09375 0.680454147196262 0.836743235337049 1 GO:0160041 neuropeptide activity 3/2568 32/18639 0.09375 0.680454147196262 0.836743235337049 1 GO:0019902 phosphatase binding 22/2568 190/18639 0.115789473684211 0.840420560747663 0.838893432696024 1 GO:0004222 metalloendopeptidase activity 12/2568 110/18639 0.109090909090909 0.791801189464741 0.845386299787659 1 GO:0003887 DNA-directed DNA polymerase activity 2/2568 23/18639 0.0869565217391304 0.631145875660301 0.8456199842551 1 GO:0031681 G-protein beta-subunit binding 2/2568 23/18639 0.0869565217391304 0.631145875660301 0.8456199842551 1 GO:0043274 phospholipase binding 2/2568 23/18639 0.0869565217391304 0.631145875660301 0.8456199842551 1 GO:0070577 lysine-acetylated histone binding 2/2568 23/18639 0.0869565217391304 0.631145875660301 0.8456199842551 1 GO:0004721 phosphoprotein phosphatase activity 20/2568 175/18639 0.114285714285714 0.829506008010681 0.845650716913395 1 GO:0022843 voltage-gated monoatomic cation channel activity 16/2568 143/18639 0.111888111888112 0.812103784066401 0.84759945477732 1 GO:0008238 exopeptidase activity 11/2568 102/18639 0.107843137254902 0.78274463991204 0.847820433975288 1 GO:0015171 amino acid transmembrane transporter activity 11/2568 102/18639 0.107843137254902 0.78274463991204 0.847820433975288 1 GO:0035198 miRNA binding 4/2568 42/18639 0.0952380952380952 0.691255006675567 0.848975747019691 1 GO:0048487 beta-tubulin binding 4/2568 42/18639 0.0952380952380952 0.691255006675567 0.848975747019691 1 GO:0019956 chemokine binding 3/2568 33/18639 0.0909090909090909 0.659834324553951 0.851936373183923 1 GO:0140311 protein sequestering activity 3/2568 33/18639 0.0909090909090909 0.659834324553951 0.851936373183923 1 GO:0004465 lipoprotein lipase activity 1/2568 13/18639 0.0769230769230769 0.558321351545651 0.854530060675946 1 GO:0004535 poly(A)-specific ribonuclease activity 1/2568 13/18639 0.0769230769230769 0.558321351545651 0.854530060675946 1 GO:0004993 G protein-coupled serotonin receptor activity 1/2568 13/18639 0.0769230769230769 0.558321351545651 0.854530060675946 1 GO:0008417 fucosyltransferase activity 1/2568 13/18639 0.0769230769230769 0.558321351545651 0.854530060675946 1 GO:0019855 calcium channel inhibitor activity 1/2568 13/18639 0.0769230769230769 0.558321351545651 0.854530060675946 1 GO:0030955 potassium ion binding 1/2568 13/18639 0.0769230769230769 0.558321351545651 0.854530060675946 1 GO:0046974 histone H3K9 methyltransferase activity 1/2568 13/18639 0.0769230769230769 0.558321351545651 0.854530060675946 1 GO:0061459 L-arginine transmembrane transporter activity 1/2568 13/18639 0.0769230769230769 0.558321351545651 0.854530060675946 1 GO:0070123 transforming growth factor beta receptor activity, type III 1/2568 13/18639 0.0769230769230769 0.558321351545651 0.854530060675946 1 GO:0070700 BMP receptor binding 1/2568 13/18639 0.0769230769230769 0.558321351545651 0.854530060675946 1 GO:0071837 HMG box domain binding 1/2568 13/18639 0.0769230769230769 0.558321351545651 0.854530060675946 1 GO:0140333 glycerophospholipid flippase activity 1/2568 13/18639 0.0769230769230769 0.558321351545651 0.854530060675946 1 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 1/2568 13/18639 0.0769230769230769 0.558321351545651 0.854530060675946 1 GO:0002039 p53 binding 7/2568 69/18639 0.101449275362319 0.736336854937018 0.855417285341673 1 GO:0016779 nucleotidyltransferase activity 15/2568 136/18639 0.110294117647059 0.800534290819131 0.8562113200316 1 GO:0005253 monoatomic anion channel activity 11/2568 103/18639 0.106796116504854 0.775145177388622 0.856456825519155 1 GO:0001653 peptide receptor activity 14/2568 128/18639 0.109375 0.793863171728972 0.857725996574539 1 GO:0004867 serine-type endopeptidase inhibitor activity 10/2568 95/18639 0.105263157894737 0.764018691588785 0.859702295919259 1 GO:0003774 cytoskeletal motor activity 17/2568 153/18639 0.111111111111111 0.806464174454829 0.861035641475172 1 GO:0008375 acetylglucosaminyltransferase activity 4/2568 43/18639 0.0930232558139535 0.675179308845903 0.861734950327335 1 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 4/2568 43/18639 0.0930232558139535 0.675179308845903 0.861734950327335 1 GO:0005540 hyaluronic acid binding 2/2568 24/18639 0.0833333333333333 0.604848130841122 0.862359324105705 1 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 2/2568 24/18639 0.0833333333333333 0.604848130841122 0.862359324105705 1 GO:0140033 acetylation-dependent protein binding 2/2568 24/18639 0.0833333333333333 0.604848130841122 0.862359324105705 1 GO:0008028 monocarboxylic acid transmembrane transporter activity 7/2568 70/18639 0.1 0.725817757009346 0.865347607083531 1 GO:0016831 carboxy-lyase activity 3/2568 34/18639 0.0882352941176471 0.640427432655305 0.865880076912266 1 GO:0030332 cyclin binding 3/2568 34/18639 0.0882352941176471 0.640427432655305 0.865880076912266 1 GO:0090482 vitamin transmembrane transporter activity 3/2568 34/18639 0.0882352941176471 0.640427432655305 0.865880076912266 1 GO:0015108 chloride transmembrane transporter activity 13/2568 121/18639 0.107438016528926 0.779804201745578 0.867168255434701 1 GO:0015370 solute:sodium symporter activity 8/2568 79/18639 0.10126582278481 0.735005323553768 0.868620671968666 1 GO:0031267 small GTPase binding 33/2568 283/18639 0.11660777385159 0.846359928668142 0.871751024308501 1 GO:0005246 calcium channel regulator activity 5/2568 53/18639 0.0943396226415094 0.684733733027685 0.872158814609957 1 GO:0005544 calcium-dependent phospholipid binding 5/2568 53/18639 0.0943396226415094 0.684733733027685 0.872158814609957 1 GO:0001046 core promoter sequence-specific DNA binding 4/2568 44/18639 0.0909090909090909 0.659834324553951 0.873559924165002 1 GO:0008528 G protein-coupled peptide receptor activity 13/2568 122/18639 0.10655737704918 0.773412364026352 0.874410830183365 1 GO:0005344 oxygen carrier activity 1/2568 14/18639 0.0714285714285714 0.518441255006676 0.874586261909929 1 GO:0008392 arachidonate epoxygenase activity 1/2568 14/18639 0.0714285714285714 0.518441255006676 0.874586261909929 1 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 1/2568 14/18639 0.0714285714285714 0.518441255006676 0.874586261909929 1 GO:0032454 histone H3K9 demethylase activity 1/2568 14/18639 0.0714285714285714 0.518441255006676 0.874586261909929 1 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 1/2568 14/18639 0.0714285714285714 0.518441255006676 0.874586261909929 1 GO:0043176 amine binding 1/2568 14/18639 0.0714285714285714 0.518441255006676 0.874586261909929 1 GO:0046030 inositol trisphosphate phosphatase activity 1/2568 14/18639 0.0714285714285714 0.518441255006676 0.874586261909929 1 GO:0061665 SUMO ligase activity 1/2568 14/18639 0.0714285714285714 0.518441255006676 0.874586261909929 1 GO:0071933 Arp2/3 complex binding 1/2568 14/18639 0.0714285714285714 0.518441255006676 0.874586261909929 1 GO:0098821 BMP receptor activity 1/2568 14/18639 0.0714285714285714 0.518441255006676 0.874586261909929 1 GO:0140767 enzyme-substrate adaptor activity 15/2568 139/18639 0.107913669064748 0.783256572312244 0.877157222980091 1 GO:0001848 complement binding 2/2568 25/18639 0.08 0.580654205607477 0.877418689428894 1 GO:0003707 nuclear steroid receptor activity 2/2568 25/18639 0.08 0.580654205607477 0.877418689428894 1 GO:0008483 transaminase activity 2/2568 25/18639 0.08 0.580654205607477 0.877418689428894 1 GO:0042974 nuclear retinoic acid receptor binding 2/2568 25/18639 0.08 0.580654205607477 0.877418689428894 1 GO:0000149 SNARE binding 11/2568 106/18639 0.10377358490566 0.753207106330453 0.880059456660094 1 GO:0003727 single-stranded RNA binding 9/2568 89/18639 0.101123595505618 0.73397301270608 0.880396933357189 1 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 26/2568 229/18639 0.11353711790393 0.824072562543362 0.880444572898265 1 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 20/2568 181/18639 0.110497237569061 0.802008571281045 0.883096371198287 1 GO:0101005 deubiquitinase activity 12/2568 115/18639 0.104347826086957 0.757375050792361 0.884018913009589 1 GO:0004715 non-membrane spanning protein tyrosine kinase activity 4/2568 45/18639 0.0888888888888889 0.645171339563863 0.884500330182922 1 GO:0140303 intramembrane lipid transporter activity 4/2568 45/18639 0.0888888888888889 0.645171339563863 0.884500330182922 1 GO:0005267 potassium channel activity 13/2568 124/18639 0.104838709677419 0.760937971058185 0.887949262052793 1 GO:0004190 aspartic-type endopeptidase activity 3/2568 36/18639 0.0833333333333333 0.604848130841122 0.890331781015489 1 GO:0001637 G protein-coupled chemoattractant receptor activity 2/2568 26/18639 0.0769230769230769 0.558321351545651 0.890943046918917 1 GO:0004950 chemokine receptor activity 2/2568 26/18639 0.0769230769230769 0.558321351545651 0.890943046918917 1 GO:0005227 calcium-activated cation channel activity 2/2568 26/18639 0.0769230769230769 0.558321351545651 0.890943046918917 1 GO:0008066 glutamate receptor activity 2/2568 26/18639 0.0769230769230769 0.558321351545651 0.890943046918917 1 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 2/2568 26/18639 0.0769230769230769 0.558321351545651 0.890943046918917 1 GO:0019865 immunoglobulin binding 2/2568 26/18639 0.0769230769230769 0.558321351545651 0.890943046918917 1 GO:0034237 protein kinase A regulatory subunit binding 2/2568 26/18639 0.0769230769230769 0.558321351545651 0.890943046918917 1 GO:0070006 metalloaminopeptidase activity 2/2568 26/18639 0.0769230769230769 0.558321351545651 0.890943046918917 1 GO:0097602 cullin family protein binding 2/2568 26/18639 0.0769230769230769 0.558321351545651 0.890943046918917 1 GO:0098632 cell-cell adhesion mediator activity 5/2568 55/18639 0.0909090909090909 0.659834324553951 0.89181645226241 1 GO:0004953 icosanoid receptor activity 1/2568 15/18639 0.0666666666666667 0.483878504672897 0.891878207113435 1 GO:0015250 water channel activity 1/2568 15/18639 0.0666666666666667 0.483878504672897 0.891878207113435 1 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 1/2568 15/18639 0.0666666666666667 0.483878504672897 0.891878207113435 1 GO:0047372 monoacylglycerol lipase activity 1/2568 15/18639 0.0666666666666667 0.483878504672897 0.891878207113435 1 GO:0050780 dopamine receptor binding 1/2568 15/18639 0.0666666666666667 0.483878504672897 0.891878207113435 1 GO:0120283 protein serine/threonine kinase binding 1/2568 15/18639 0.0666666666666667 0.483878504672897 0.891878207113435 1 GO:0141050 histone H3K deacetylase activity 1/2568 15/18639 0.0666666666666667 0.483878504672897 0.891878207113435 1 GO:0141051 histone H4K deacetylase activity 1/2568 15/18639 0.0666666666666667 0.483878504672897 0.891878207113435 1 GO:0043394 proteoglycan binding 3/2568 37/18639 0.0810810810810811 0.588500884061632 0.900992773632055 1 GO:0070001 aspartic-type peptidase activity 3/2568 37/18639 0.0810810810810811 0.588500884061632 0.900992773632055 1 GO:0008266 poly(U) RNA binding 2/2568 27/18639 0.0740740740740741 0.537642782969886 0.903069323135976 1 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 2/2568 27/18639 0.0740740740740741 0.537642782969886 0.903069323135976 1 GO:0140938 histone H3 methyltransferase activity 4/2568 47/18639 0.0851063829787234 0.617717240007954 0.903925557577284 1 GO:0003688 DNA replication origin binding 1/2568 16/18639 0.0625 0.453636098130841 0.906786753297537 1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 1/2568 16/18639 0.0625 0.453636098130841 0.906786753297537 1 GO:0004707 MAP kinase activity 1/2568 16/18639 0.0625 0.453636098130841 0.906786753297537 1 GO:0005024 transforming growth factor beta receptor activity 1/2568 16/18639 0.0625 0.453636098130841 0.906786753297537 1 GO:0008296 3'-5'-DNA exonuclease activity 1/2568 16/18639 0.0625 0.453636098130841 0.906786753297537 1 GO:0008391 arachidonate monooxygenase activity 1/2568 16/18639 0.0625 0.453636098130841 0.906786753297537 1 GO:0015378 sodium:chloride symporter activity 1/2568 16/18639 0.0625 0.453636098130841 0.906786753297537 1 GO:0015385 sodium:proton antiporter activity 1/2568 16/18639 0.0625 0.453636098130841 0.906786753297537 1 GO:0070411 I-SMAD binding 1/2568 16/18639 0.0625 0.453636098130841 0.906786753297537 1 GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 1/2568 16/18639 0.0625 0.453636098130841 0.906786753297537 1 GO:0140328 floppase activity 1/2568 16/18639 0.0625 0.453636098130841 0.906786753297537 1 GO:0051213 dioxygenase activity 9/2568 93/18639 0.0967741935483871 0.702404280976786 0.908764201910662 1 GO:0008017 microtubule binding 31/2568 276/18639 0.11231884057971 0.815230089394555 0.910230314335143 1 GO:0000146 microfilament motor activity 3/2568 38/18639 0.0789473684210526 0.573014018691589 0.910708937067476 1 GO:0005501 retinoid binding 3/2568 38/18639 0.0789473684210526 0.573014018691589 0.910708937067476 1 GO:0019840 isoprenoid binding 3/2568 38/18639 0.0789473684210526 0.573014018691589 0.910708937067476 1 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 13/2568 128/18639 0.1015625 0.737158659462617 0.911473641874225 1 GO:0008188 neuropeptide receptor activity 4/2568 48/18639 0.0833333333333333 0.604848130841122 0.912507826108005 1 GO:0038187 pattern recognition receptor activity 4/2568 48/18639 0.0833333333333333 0.604848130841122 0.912507826108005 1 GO:0001216 DNA-binding transcription activator activity 58/2568 491/18639 0.118126272912424 0.857381464491692 0.913134946258366 1 GO:0046966 nuclear thyroid hormone receptor binding 2/2568 28/18639 0.0714285714285714 0.518441255006676 0.913925867633386 1 GO:0050698 proteoglycan sulfotransferase activity 2/2568 28/18639 0.0714285714285714 0.518441255006676 0.913925867633386 1 GO:0051119 sugar transmembrane transporter activity 2/2568 28/18639 0.0714285714285714 0.518441255006676 0.913925867633386 1 GO:0004175 endopeptidase activity 47/2568 405/18639 0.116049382716049 0.842307026652821 0.914862830960988 1 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 57/2568 484/18639 0.117768595041322 0.854785374990345 0.915477202067558 1 GO:0004722 protein serine/threonine phosphatase activity 10/2568 103/18639 0.0970873786407767 0.704677433989656 0.916206515504542 1 GO:0061980 regulatory RNA binding 5/2568 58/18639 0.0862068965517241 0.625704962939091 0.916393276244748 1 GO:0015347 sodium-independent organic anion transmembrane transporter activity 1/2568 17/18639 0.0588235294117647 0.426951621770203 0.919640300928527 1 GO:0030548 acetylcholine receptor regulator activity 1/2568 17/18639 0.0588235294117647 0.426951621770203 0.919640300928527 1 GO:0031489 myosin V binding 1/2568 17/18639 0.0588235294117647 0.426951621770203 0.919640300928527 1 GO:0036041 long-chain fatty acid binding 1/2568 17/18639 0.0588235294117647 0.426951621770203 0.919640300928527 1 GO:0045125 bioactive lipid receptor activity 1/2568 17/18639 0.0588235294117647 0.426951621770203 0.919640300928527 1 GO:0045236 CXCR chemokine receptor binding 1/2568 17/18639 0.0588235294117647 0.426951621770203 0.919640300928527 1 GO:0046965 nuclear retinoid X receptor binding 1/2568 17/18639 0.0588235294117647 0.426951621770203 0.919640300928527 1 GO:0070403 NAD+ binding 1/2568 17/18639 0.0588235294117647 0.426951621770203 0.919640300928527 1 GO:0140223 general transcription initiation factor activity 6/2568 68/18639 0.0882352941176471 0.640427432655305 0.921135772421608 1 GO:0004879 nuclear receptor activity 5/2568 59/18639 0.0847457627118644 0.615099794075717 0.923415958708571 1 GO:0036002 pre-mRNA binding 5/2568 59/18639 0.0847457627118644 0.615099794075717 0.923415958708571 1 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 12/2568 122/18639 0.0983606557377049 0.713919105255094 0.924574186752066 1 GO:0003713 transcription coactivator activity 28/2568 256/18639 0.109375 0.793863171728972 0.925640096996533 1 GO:0008080 N-acetyltransferase activity 6/2568 69/18639 0.0869565217391304 0.631145875660301 0.92739467595303 1 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 5/2568 60/18639 0.0833333333333333 0.604848130841122 0.929910191017369 1 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 5/2568 60/18639 0.0833333333333333 0.604848130841122 0.929910191017369 1 GO:0098531 ligand-modulated transcription factor activity 5/2568 60/18639 0.0833333333333333 0.604848130841122 0.929910191017369 1 GO:0000900 mRNA regulatory element binding translation repressor activity 1/2568 18/18639 0.0555555555555556 0.403232087227414 0.930722016491599 1 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 1/2568 18/18639 0.0555555555555556 0.403232087227414 0.930722016491599 1 GO:0004970 glutamate-gated receptor activity 1/2568 18/18639 0.0555555555555556 0.403232087227414 0.930722016491599 1 GO:0005372 water transmembrane transporter activity 1/2568 18/18639 0.0555555555555556 0.403232087227414 0.930722016491599 1 GO:0008409 5'-3' exonuclease activity 1/2568 18/18639 0.0555555555555556 0.403232087227414 0.930722016491599 1 GO:0015373 monoatomic anion:sodium symporter activity 1/2568 18/18639 0.0555555555555556 0.403232087227414 0.930722016491599 1 GO:0022851 GABA-gated chloride ion channel activity 1/2568 18/18639 0.0555555555555556 0.403232087227414 0.930722016491599 1 GO:0032393 MHC class I receptor activity 1/2568 18/18639 0.0555555555555556 0.403232087227414 0.930722016491599 1 GO:0035615 clathrin adaptor activity 1/2568 18/18639 0.0555555555555556 0.403232087227414 0.930722016491599 1 GO:0050811 GABA receptor binding 1/2568 18/18639 0.0555555555555556 0.403232087227414 0.930722016491599 1 GO:0098641 cadherin binding involved in cell-cell adhesion 1/2568 18/18639 0.0555555555555556 0.403232087227414 0.930722016491599 1 GO:0099602 neurotransmitter receptor regulator activity 1/2568 18/18639 0.0555555555555556 0.403232087227414 0.930722016491599 1 GO:0008187 poly-pyrimidine tract binding 2/2568 30/18639 0.0666666666666667 0.483878504672897 0.93229908370739 1 GO:0022839 monoatomic ion-gated channel activity 2/2568 30/18639 0.0666666666666667 0.483878504672897 0.93229908370739 1 GO:0031624 ubiquitin conjugating enzyme binding 2/2568 30/18639 0.0666666666666667 0.483878504672897 0.93229908370739 1 GO:0032452 histone demethylase activity 2/2568 30/18639 0.0666666666666667 0.483878504672897 0.93229908370739 1 GO:0016782 transferase activity, transferring sulphur-containing groups 6/2568 70/18639 0.0857142857142857 0.622129506008011 0.933211588659546 1 GO:0019842 vitamin binding 15/2568 150/18639 0.1 0.725817757009346 0.934014726900083 1 GO:0008237 metallopeptidase activity 19/2568 184/18639 0.103260869565217 0.749485727346607 0.934239178288985 1 GO:0005272 sodium channel activity 4/2568 51/18639 0.0784313725490196 0.569268829026938 0.934293081371973 1 GO:0001727 lipid kinase activity 3/2568 41/18639 0.0731707317073171 0.531086163665375 0.934875990708337 1 GO:0005249 voltage-gated potassium channel activity 9/2568 98/18639 0.0918367346938776 0.666567327865726 0.936022537553849 1 GO:0015079 potassium ion transmembrane transporter activity 16/2568 160/18639 0.1 0.725817757009346 0.939397850442187 1 GO:0140457 protein demethylase activity 2/2568 31/18639 0.0645161290322581 0.468269520651191 0.940028522231819 1 GO:0004890 GABA-A receptor activity 1/2568 19/18639 0.0526315789473684 0.382009345794392 0.940276060938706 1 GO:0008301 DNA binding, bending 1/2568 19/18639 0.0526315789473684 0.382009345794392 0.940276060938706 1 GO:0008381 mechanosensitive monoatomic ion channel activity 1/2568 19/18639 0.0526315789473684 0.382009345794392 0.940276060938706 1 GO:0008574 plus-end-directed microtubule motor activity 1/2568 19/18639 0.0526315789473684 0.382009345794392 0.940276060938706 1 GO:0042800 histone H3K4 methyltransferase activity 1/2568 19/18639 0.0526315789473684 0.382009345794392 0.940276060938706 1 GO:0042834 peptidoglycan binding 1/2568 19/18639 0.0526315789473684 0.382009345794392 0.940276060938706 1 GO:0099589 serotonin receptor activity 1/2568 19/18639 0.0526315789473684 0.382009345794392 0.940276060938706 1 GO:0004843 cysteine-type deubiquitinase activity 10/2568 108/18639 0.0925925925925926 0.672053478712357 0.940643825393448 1 GO:0031492 nucleosomal DNA binding 3/2568 42/18639 0.0714285714285714 0.518441255006676 0.94148370176131 1 GO:0140789 histone phosphatase activity 13/2568 136/18639 0.0955882352941176 0.693796385376581 0.946299663872727 1 GO:0016004 phospholipase activator activity 1/2568 20/18639 0.05 0.362908878504673 0.948512960804947 1 GO:0042288 MHC class I protein binding 1/2568 20/18639 0.05 0.362908878504673 0.948512960804947 1 GO:0052745 inositol phosphate phosphatase activity 1/2568 20/18639 0.05 0.362908878504673 0.948512960804947 1 GO:0031490 chromatin DNA binding 12/2568 128/18639 0.09375 0.680454147196262 0.949075385470169 1 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 7/2568 83/18639 0.0843373493975904 0.612135457718725 0.95057013634937 1 GO:0031491 nucleosome binding 6/2568 74/18639 0.0810810810810811 0.588500884061632 0.952550688203111 1 GO:0048029 monosaccharide binding 6/2568 74/18639 0.0810810810810811 0.588500884061632 0.952550688203111 1 GO:0019239 deaminase activity 2/2568 33/18639 0.0606060606060606 0.439889549702634 0.953041810272603 1 GO:0030296 protein tyrosine kinase activator activity 2/2568 33/18639 0.0606060606060606 0.439889549702634 0.953041810272603 1 GO:0004527 exonuclease activity 7/2568 84/18639 0.0833333333333333 0.604848130841122 0.954482336372301 1 GO:0120013 lipid transfer activity 5/2568 65/18639 0.0769230769230769 0.558321351545651 0.955550325330105 1 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 1/2568 21/18639 0.0476190476190476 0.345627503337784 0.955614239963489 1 GO:0001846 opsonin binding 1/2568 21/18639 0.0476190476190476 0.345627503337784 0.955614239963489 1 GO:0005248 voltage-gated sodium channel activity 1/2568 21/18639 0.0476190476190476 0.345627503337784 0.955614239963489 1 GO:0051010 microtubule plus-end binding 1/2568 21/18639 0.0476190476190476 0.345627503337784 0.955614239963489 1 GO:0061891 calcium ion sensor activity 1/2568 21/18639 0.0476190476190476 0.345627503337784 0.955614239963489 1 GO:0140312 cargo adaptor activity 1/2568 21/18639 0.0476190476190476 0.345627503337784 0.955614239963489 1 GO:0030295 protein kinase activator activity 13/2568 139/18639 0.0935251798561151 0.678822362670611 0.955890608381062 1 GO:0016410 N-acyltransferase activity 8/2568 94/18639 0.0851063829787234 0.617717240007954 0.956736076505883 1 GO:0046915 transition metal ion transmembrane transporter activity 3/2568 45/18639 0.0666666666666667 0.483878504672897 0.957756265215194 1 GO:0015020 glucuronosyltransferase activity 2/2568 34/18639 0.0588235294117647 0.426951621770203 0.958489418607624 1 GO:0019825 oxygen binding 2/2568 34/18639 0.0588235294117647 0.426951621770203 0.958489418607624 1 GO:0008235 metalloexopeptidase activity 5/2568 66/18639 0.0757575757575758 0.549861937128292 0.959514426512268 1 GO:0030170 pyridoxal phosphate binding 4/2568 56/18639 0.0714285714285714 0.518441255006676 0.959918631347852 1 GO:0004674 protein serine/threonine kinase activity 48/2568 433/18639 0.110854503464203 0.804601670587727 0.959993234636204 1 GO:0015631 tubulin binding 42/2568 385/18639 0.109090909090909 0.791801189464741 0.96110349914793 1 GO:0005243 gap junction channel activity 1/2568 22/18639 0.0454545454545455 0.329917162276975 0.961736413761628 1 GO:0033038 bitter taste receptor activity 1/2568 22/18639 0.0454545454545455 0.329917162276975 0.961736413761628 1 GO:0050321 tau-protein kinase activity 1/2568 22/18639 0.0454545454545455 0.329917162276975 0.961736413761628 1 GO:0004180 carboxypeptidase activity 3/2568 46/18639 0.0652173913043478 0.473359406745225 0.962162110246345 1 GO:0034061 DNA polymerase activity 2/2568 35/18639 0.0571428571428571 0.41475300400534 0.963328004622956 1 GO:0070279 vitamin B6 binding 4/2568 57/18639 0.0701754385964912 0.509345794392523 0.963775982377786 1 GO:0004677 DNA-dependent protein kinase activity 25/2568 246/18639 0.101626016260163 0.737619671757465 0.964245967563665 1 GO:0017124 SH3 domain binding 10/2568 115/18639 0.0869565217391304 0.631145875660301 0.964333406497301 1 GO:0003777 microtubule motor activity 5/2568 68/18639 0.0735294117647059 0.533689527212754 0.966486571283116 1 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 1/2568 23/18639 0.0434782608695652 0.31557293783015 0.967014433284652 1 GO:0016493 C-C chemokine receptor activity 1/2568 23/18639 0.0434782608695652 0.31557293783015 0.967014433284652 1 GO:0016917 GABA receptor activity 1/2568 23/18639 0.0434782608695652 0.31557293783015 0.967014433284652 1 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 1/2568 23/18639 0.0434782608695652 0.31557293783015 0.967014433284652 1 GO:0004679 AMP-activated protein kinase activity 25/2568 248/18639 0.100806451612903 0.731671126017486 0.967863182343015 1 GO:0042277 peptide binding 25/2568 249/18639 0.100401606425703 0.728732687760387 0.969548499880968 1 GO:0004806 triacylglycerol lipase activity 1/2568 24/18639 0.0416666666666667 0.302424065420561 0.971564655422868 1 GO:0015149 hexose transmembrane transporter activity 1/2568 24/18639 0.0416666666666667 0.302424065420561 0.971564655422868 1 GO:0019957 C-C chemokine binding 1/2568 24/18639 0.0416666666666667 0.302424065420561 0.971564655422868 1 GO:0030215 semaphorin receptor binding 1/2568 24/18639 0.0416666666666667 0.302424065420561 0.971564655422868 1 GO:0055056 D-glucose transmembrane transporter activity 1/2568 24/18639 0.0416666666666667 0.302424065420561 0.971564655422868 1 GO:0060229 lipase activator activity 1/2568 24/18639 0.0416666666666667 0.302424065420561 0.971564655422868 1 GO:0048306 calcium-dependent protein binding 6/2568 80/18639 0.075 0.544363317757009 0.972196378259892 1 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 24/2568 243/18639 0.0987654320987654 0.716857043959848 0.973505610777503 1 GO:0033192 calmodulin-dependent protein phosphatase activity 6/2568 81/18639 0.0740740740740741 0.537642782969886 0.974625493910756 1 GO:0140791 histone H2AXS140 phosphatase activity 6/2568 81/18639 0.0740740740740741 0.537642782969886 0.974625493910756 1 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 6/2568 81/18639 0.0740740740740741 0.537642782969886 0.974625493910756 1 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 6/2568 81/18639 0.0740740740740741 0.537642782969886 0.974625493910756 1 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 6/2568 81/18639 0.0740740740740741 0.537642782969886 0.974625493910756 1 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 6/2568 81/18639 0.0740740740740741 0.537642782969886 0.974625493910756 1 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 6/2568 81/18639 0.0740740740740741 0.537642782969886 0.974625493910756 1 GO:1990439 MAP kinase serine/threonine phosphatase activity 6/2568 81/18639 0.0740740740740741 0.537642782969886 0.974625493910756 1 GO:0141003 histone H2AX kinase activity 37/2568 354/18639 0.104519774011299 0.758623079360051 0.975352626742891 1 GO:0005251 delayed rectifier potassium channel activity 1/2568 25/18639 0.04 0.290327102803738 0.97548740400595 1 GO:0008139 nuclear localization sequence binding 1/2568 25/18639 0.04 0.290327102803738 0.97548740400595 1 GO:0015662 P-type ion transporter activity 1/2568 25/18639 0.04 0.290327102803738 0.97548740400595 1 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 1/2568 25/18639 0.04 0.290327102803738 0.97548740400595 1 GO:0017056 structural constituent of nuclear pore 1/2568 25/18639 0.04 0.290327102803738 0.97548740400595 1 GO:0120020 cholesterol transfer activity 1/2568 25/18639 0.04 0.290327102803738 0.97548740400595 1 GO:0140358 P-type transmembrane transporter activity 1/2568 25/18639 0.04 0.290327102803738 0.97548740400595 1 GO:0048020 CCR chemokine receptor binding 3/2568 50/18639 0.06 0.435490654205607 0.975813529263118 1 GO:0019209 kinase activator activity 13/2568 148/18639 0.0878378378378378 0.637542624400101 0.976235569329664 1 GO:0004676 3-phosphoinositide-dependent protein kinase activity 24/2568 245/18639 0.0979591836734694 0.711005149723441 0.976321249886489 1 GO:0004711 ribosomal protein S6 kinase activity 24/2568 245/18639 0.0979591836734694 0.711005149723441 0.976321249886489 1 GO:0035175 histone H3S10 kinase activity 24/2568 245/18639 0.0979591836734694 0.711005149723441 0.976321249886489 1 GO:0035979 histone H2AXS139 kinase activity 24/2568 245/18639 0.0979591836734694 0.711005149723441 0.976321249886489 1 GO:0044022 histone H3S28 kinase activity 24/2568 245/18639 0.0979591836734694 0.711005149723441 0.976321249886489 1 GO:0044023 histone H4S1 kinase activity 24/2568 245/18639 0.0979591836734694 0.711005149723441 0.976321249886489 1 GO:0044024 histone H2AS1 kinase activity 24/2568 245/18639 0.0979591836734694 0.711005149723441 0.976321249886489 1 GO:0044025 histone H2BS14 kinase activity 24/2568 245/18639 0.0979591836734694 0.711005149723441 0.976321249886489 1 GO:0072354 histone H3T3 kinase activity 24/2568 245/18639 0.0979591836734694 0.711005149723441 0.976321249886489 1 GO:0072371 histone H2AS121 kinase activity 24/2568 245/18639 0.0979591836734694 0.711005149723441 0.976321249886489 1 GO:0072518 Rho-dependent protein serine/threonine kinase activity 24/2568 245/18639 0.0979591836734694 0.711005149723441 0.976321249886489 1 GO:0140823 histone H2BS36 kinase activity 24/2568 245/18639 0.0979591836734694 0.711005149723441 0.976321249886489 1 GO:0140855 histone H3S57 kinase activity 24/2568 245/18639 0.0979591836734694 0.711005149723441 0.976321249886489 1 GO:0140995 histone H2A kinase activity 24/2568 245/18639 0.0979591836734694 0.711005149723441 0.976321249886489 1 GO:0140997 histone H4 kinase activity 24/2568 245/18639 0.0979591836734694 0.711005149723441 0.976321249886489 1 GO:0140998 histone H2B kinase activity 24/2568 245/18639 0.0979591836734694 0.711005149723441 0.976321249886489 1 GO:1990244 histone H2AT120 kinase activity 24/2568 245/18639 0.0979591836734694 0.711005149723441 0.976321249886489 1 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 6/2568 82/18639 0.0731707317073171 0.531086163665375 0.976857009082287 1 GO:0033549 MAP kinase phosphatase activity 6/2568 82/18639 0.0731707317073171 0.531086163665375 0.976857009082287 1 GO:0042379 chemokine receptor binding 5/2568 72/18639 0.0694444444444444 0.504040109034268 0.977223614371813 1 GO:0140857 histone H3T45 kinase activity 24/2568 246/18639 0.0975609756097561 0.708114884887167 0.977626685813281 1 GO:0005048 signal sequence binding 3/2568 51/18639 0.0588235294117647 0.426951621770203 0.978408557256315 1 GO:0140996 histone H3 kinase activity 37/2568 357/18639 0.103641456582633 0.752248095499882 0.978651129783889 1 GO:0035402 histone H3T11 kinase activity 24/2568 247/18639 0.097165991902834 0.705248023005032 0.978867580998087 1 GO:0035403 histone H3T6 kinase activity 24/2568 247/18639 0.097165991902834 0.705248023005032 0.978867580998087 1 GO:0004529 DNA exonuclease activity 1/2568 26/18639 0.0384615384615385 0.279160675772825 0.978869178289431 1 GO:0015145 monosaccharide transmembrane transporter activity 1/2568 26/18639 0.0384615384615385 0.279160675772825 0.978869178289431 1 GO:0030507 spectrin binding 1/2568 26/18639 0.0384615384615385 0.279160675772825 0.978869178289431 1 GO:0050681 nuclear androgen receptor binding 1/2568 26/18639 0.0384615384615385 0.279160675772825 0.978869178289431 1 GO:0051139 metal cation:proton antiporter activity 1/2568 26/18639 0.0384615384615385 0.279160675772825 0.978869178289431 1 GO:0052742 phosphatidylinositol kinase activity 1/2568 26/18639 0.0384615384615385 0.279160675772825 0.978869178289431 1 GO:0005254 chloride channel activity 6/2568 83/18639 0.072289156626506 0.524687535187479 0.978905336827709 1 GO:0017018 myosin phosphatase activity 6/2568 84/18639 0.0714285714285714 0.518441255006676 0.980784029170433 1 GO:0035173 histone kinase activity 37/2568 360/18639 0.102777777777778 0.745979361370717 0.981552968776241 1 GO:0005104 fibroblast growth factor receptor binding 1/2568 27/18639 0.037037037037037 0.268821391484943 0.981784557333795 1 GO:0042287 MHC protein binding 2/2568 41/18639 0.0487804878048781 0.354057442443583 0.982767732782845 1 GO:0140828 metal cation:monoatomic cation antiporter activity 2/2568 41/18639 0.0487804878048781 0.354057442443583 0.982767732782845 1 GO:0034212 protein N-acetyltransferase activity 3/2568 53/18639 0.0566037735849057 0.410840239816611 0.982824014217673 1 GO:0005125 cytokine activity 22/2568 234/18639 0.094017094017094 0.68239276300024 0.983695867952298 1 GO:0005242 inward rectifier potassium channel activity 1/2568 28/18639 0.0357142857142857 0.259220627503338 0.984297842137514 1 GO:0008527 taste receptor activity 1/2568 28/18639 0.0357142857142857 0.259220627503338 0.984297842137514 1 GO:0036408 histone H3K14 acetyltransferase activity 1/2568 28/18639 0.0357142857142857 0.259220627503338 0.984297842137514 1 GO:0045499 chemorepellent activity 1/2568 28/18639 0.0357142857142857 0.259220627503338 0.984297842137514 1 GO:0046875 ephrin receptor binding 1/2568 28/18639 0.0357142857142857 0.259220627503338 0.984297842137514 1 GO:0141052 histone H3 demethylase activity 1/2568 28/18639 0.0357142857142857 0.259220627503338 0.984297842137514 1 GO:0015081 sodium ion transmembrane transporter activity 14/2568 164/18639 0.0853658536585366 0.619600524276271 0.98544292217056 1 GO:0004181 metallocarboxypeptidase activity 1/2568 29/18639 0.0344827586206897 0.250281985175636 0.98646447162496 1 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 1/2568 29/18639 0.0344827586206897 0.250281985175636 0.98646447162496 1 GO:0010484 histone H3 acetyltransferase activity 1/2568 29/18639 0.0344827586206897 0.250281985175636 0.98646447162496 1 GO:0097472 cyclin-dependent protein kinase activity 1/2568 29/18639 0.0344827586206897 0.250281985175636 0.98646447162496 1 GO:0106222 lncRNA binding 1/2568 29/18639 0.0344827586206897 0.250281985175636 0.98646447162496 1 GO:0004712 protein serine/threonine/tyrosine kinase activity 2/2568 43/18639 0.0465116279069767 0.337589654422952 0.986654718539534 1 GO:0140375 immune receptor activity 13/2568 156/18639 0.0833333333333333 0.604848130841122 0.986732027953891 1 GO:0015085 calcium ion transmembrane transporter activity 12/2568 147/18639 0.0816326530612245 0.592504291436201 0.987094701742137 1 GO:0001223 transcription coactivator binding 2/2568 44/18639 0.0454545454545455 0.329917162276975 0.988263393888415 1 GO:0043995 histone H4K5 acetyltransferase activity 1/2568 30/18639 0.0333333333333333 0.241939252336449 0.988332243622118 1 GO:0043996 histone H4K8 acetyltransferase activity 1/2568 30/18639 0.0333333333333333 0.241939252336449 0.988332243622118 1 GO:0043997 histone H4K12 acetyltransferase activity 1/2568 30/18639 0.0333333333333333 0.241939252336449 0.988332243622118 1 GO:0008009 chemokine activity 2/2568 45/18639 0.0444444444444444 0.322585669781931 0.989682330105774 1 GO:0008327 methyl-CpG binding 1/2568 31/18639 0.032258064516129 0.234134760325595 0.989942367668461 1 GO:0005262 calcium channel activity 10/2568 131/18639 0.0763358778625954 0.554059356495684 0.989951595867557 1 GO:0005216 monoatomic ion channel activity 46/2568 448/18639 0.102678571428571 0.745259304072096 0.989988504862088 1 GO:0120015 sterol transfer activity 1/2568 32/18639 0.03125 0.226818049065421 0.991330372818256 1 GO:0005261 monoatomic cation channel activity 33/2568 341/18639 0.0967741935483871 0.702404280976786 0.991571683078309 1 GO:0043495 protein-membrane adaptor activity 2/2568 47/18639 0.0425531914893617 0.308858620003977 0.992035492074664 1 GO:0061733 protein-lysine-acetyltransferase activity 2/2568 47/18639 0.0425531914893617 0.308858620003977 0.992035492074664 1 GO:0042923 neuropeptide binding 1/2568 33/18639 0.0303030303030303 0.219944774851317 0.992526890397808 1 GO:0106310 protein serine kinase activity 35/2568 361/18639 0.0969529085872576 0.703701426463355 0.992763526348053 1 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 1/2568 34/18639 0.0294117647058824 0.213475810885102 0.993558328936904 1 GO:0005154 epidermal growth factor receptor binding 1/2568 35/18639 0.0285714285714286 0.20737650200267 0.994447456122609 1 GO:0010485 histone H4 acetyltransferase activity 1/2568 35/18639 0.0285714285714286 0.20737650200267 0.994447456122609 1 GO:0030594 neurotransmitter receptor activity 6/2568 97/18639 0.0618556701030928 0.448959437325369 0.994564223306341 1 GO:0070851 growth factor receptor binding 10/2568 139/18639 0.0719424460431655 0.522171048208162 0.994909354738425 1 GO:0004869 cysteine-type endopeptidase inhibitor activity 1/2568 36/18639 0.0277777777777778 0.201616043613707 0.995213900579561 1 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 1/2568 36/18639 0.0277777777777778 0.201616043613707 0.995213900579561 1 GO:0030280 structural constituent of skin epidermis 1/2568 37/18639 0.027027027027027 0.196166961353877 0.995874584518264 1 GO:0005179 hormone activity 9/2568 132/18639 0.0681818181818182 0.494875743415463 0.996135346127657 1 GO:0008146 sulfotransferase activity 2/2568 53/18639 0.0377358490566038 0.273893493211074 0.996366760482208 1 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 2/2568 56/18639 0.0357142857142857 0.259220627503338 0.997556128792378 1 GO:0004402 histone acetyltransferase activity 1/2568 42/18639 0.0238095238095238 0.172813751668892 0.998037356177234 1 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 3/2568 73/18639 0.0410958904109589 0.298281270003841 0.998430765644198 1 GO:0046873 metal ion transmembrane transporter activity 42/2568 450/18639 0.0933333333333333 0.677429906542056 0.99852177297801 1 GO:0022836 gated channel activity 27/2568 318/18639 0.0849056603773585 0.616260359724916 0.998691411046462 1 GO:0022824 transmitter-gated monoatomic ion channel activity 2/2568 63/18639 0.0317460317460317 0.230418335558522 0.999039848136972 1 GO:0022835 transmitter-gated channel activity 2/2568 63/18639 0.0317460317460317 0.230418335558522 0.999039848136972 1 GO:0099095 ligand-gated monoatomic anion channel activity 1/2568 47/18639 0.0212765957446809 0.154429310001988 0.999066484011209 1 GO:0016755 aminoacyltransferase activity 45/2568 496/18639 0.0907258064516129 0.658504013415737 0.999532774201159 1 GO:0019787 ubiquitin-like protein transferase activity 43/2568 479/18639 0.0897703549060543 0.651569176438452 0.999553456231913 1 GO:0098960 postsynaptic neurotransmitter receptor activity 2/2568 69/18639 0.0289855072463768 0.210381958553434 0.999572597633549 1 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 1/2568 53/18639 0.0188679245283019 0.136946746605537 0.999617409176551 1 GO:0099094 ligand-gated monoatomic cation channel activity 7/2568 136/18639 0.0514705882352941 0.373582669048928 0.999697121746803 1 GO:0004842 ubiquitin-protein transferase activity 38/2568 449/18639 0.0846325167037862 0.614277834439981 0.999829324025467 1 GO:0015276 ligand-gated monoatomic ion channel activity 10/2568 186/18639 0.0537634408602151 0.390224600542659 0.999941661562022 1 GO:0061630 ubiquitin protein ligase activity 26/2568 353/18639 0.0736543909348442 0.534596648222181 0.999950071602498 1 GO:0022834 ligand-gated channel activity 10/2568 188/18639 0.0531914893617021 0.386073275004971 0.999952460133591 1 GO:0061659 ubiquitin-like protein ligase activity 27/2568 372/18639 0.0725806451612903 0.52680321073259 0.999975978908913 1 GO:0003730 mRNA 3'-UTR binding 16/2568 262/18639 0.0610687022900763 0.443247485196547 0.999979197844508 1 GO:0003823 antigen binding 2/2568 174/18639 0.0114942528735632 0.0834273283918788 0.999999999839491 1 GO:0045182 translation regulator activity 8/2568 356/18639 0.0224719101123595 0.163105113934684 0.999999999999997 1 GO:0004984 olfactory receptor activity 1/2568 419/18639 0.00238663484486874 0.0173226194990297 1 1 GO:0030371 translation repressor activity 2/2568 329/18639 0.0060790273556231 0.0441226600005681 1 1