category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	19/1210	41/9376	3.59088893368273	ATM/SYCP3/RAD50/BABAM2/BARD1/BRCA1/BLM/RPA2/NBN/XRCC2/XRCC3/BRCC3/RAD54B/RAD52/EME1/MRE11/BRCA2/POLD4/ABRAXAS1	6.39966438151977
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	25/1210	83/9376	2.33396395499353	PMVK/PHYH/GSTK1/ECI2/HMGCL/ABCD2/PAOX/SOD1/HACL1/AMACR/PEX7/PECR/PEX11A/ACSL5/PEX1/SLC25A17/MLYCD/FAR2/ACOX1/PXMP4/EHHADH/SOD2/ABCD3/PIPOX/MPV17	4.69871179876317
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	35/1210	137/9376	1.97961030343247	FOS/TUBA1B/ATF4/ATM/DDIT3/GADD45A/TUBA1C/CTSF/PARP4/CASP10/TNFSF10/JUN/PIK3CD/BBC3/TRADD/ITPR2/ERN1/DFFB/RIPK1/CFLAR/GADD45B/CTSL/NTRK1/CASP8/AIFM1/CTSB/DAXX/AKT3/FADD/CTSH/PRF1/TP53/BIRC5/PARP2/BCL2L1	4.44605447873608
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	38/1210	157/9376	1.87549613096805	ATM/TGFBR1/MAP2K6/GADD45A/RBL2/HLA-B/CCND3/NFATC3/SIRT1/RAD50/PIK3CD/IGFBP3/KIR2DL4/ITPR2/ATR/PPID/RRAS/E2F3/GADD45B/NBN/NFATC1/HUS1/CCNE2/SLC25A6/AKT3/SQSTM1/CCNE1/MRE11/CALML4/CHEK2/MTOR/TP53/PTEN/CCNB1/LIN37/PPP3CB/BTRC/RBL1	4.25829540085068
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	48/1210	216/9376	1.72194674012856	HSPA1B/HSPA1A/HSP90AA1/HSPA6/HSPA4/HSP90AB1/FOS/ATF4/HSPA2/CCL3L1/MAP2K6/ABCA1/CD40LG/IRAK4/DDIT3/ARHGEF1/CCL5/HSPD1/POU2F2/IRF3/IL18/CAMK2D/PLCB4/HSPA1L/NFATC3/TNFSF10/JUN/CD36/PIK3CD/ERN1/HSPA8/NCF4/MIB1/XBP1/CASP8/NFATC1/TAB1/MIB2/GSK3B/VCAM1/AKT3/CALML4/TP53/RXRB/PPP3CB/SOD2/TLR6/BCL2L1	4.13197736736395
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	23/1210	82/9376	2.17343277565007	HSPA1B/HSPA1A/HSP90AA1/HSPA6/HSPA4/KIR2DL3/HSP90AB1/KIR2DL1/HSPA2/KIR3DL1/HLA-B/CD4/HSPA1L/KIR3DL2/KIR2DL4/NFYB/HSPA8/CTSL/CTSB/LGMN/CD8B/CD8A/KLRD1	4.10806628247155
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	12/1210	32/9376	2.90578512396694	PCCA/HIBCH/ALDH6A1/SUCLG2/ECHDC1/MCEE/LDHC/BCKDHB/MLYCD/ACOX1/DBT/EHHADH	4.15677141122775
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	17/1210	57/9376	2.31103378280412	SCD5/CBR4/ACAA2/TECR/CPT2/HADH/ACAT1/CPT1A/HSD17B8/ACADSB/ELOVL6/OXSM/ACSL5/ACADM/ACOX1/MECR/EHHADH	3.82155654821413
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	15/1210	48/9376	2.42148760330579	ACAA2/PCCA/HIBCH/HADH/HMGCL/ALDH6A1/ACAT1/MCEE/AUH/ACADSB/BCKDHB/ACADM/DBT/EHHADH/ALDH9A1	3.80052034841224
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	16/1210	54/9376	2.29592898683808	BRCA1/BLM/ATR/RPA2/POLK/RMI1/FAAP24/ERCC4/EME1/FANCF/BRCA2/RMI2/ATRIP/HES1/MLH1/FANCD2	3.67618340543396
Human Diseases	Infectious disease: viral	hsa05162	Measles	31/1210	136/9376	1.76626154594069	HSPA1B/HSPA1A/CD3E/HSPA6/RACK1/FOS/IRAK4/IFNAR2/CD3D/IRF3/CD3G/CCND3/HSPA1L/SLAMF1/JUN/PIK3CD/BBC3/TRADD/EIF3H/HSPA8/CASP8/CD28/MAVS/GSK3B/CCNE2/AKT3/FADD/CCNE1/TP53/IL2RA/BCL2L1	3.46484758822324
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	34/1210	158/9376	1.66745475468145	ATM/GADD45A/RBL2/YWHAH/CCND3/CDKN2C/CDKN1C/CDKN2D/ANAPC4/ORC3/ATR/MTBP/E2F3/GADD45B/CDC16/ORC4/HDAC1/ANAPC7/GSK3B/CCNE2/CDC14B/ANAPC13/BUB1/FBXO5/CCNE1/HDAC8/CHEK2/TP53/CDC20/CCNB1/WEE1/MCM3/CDC25C/RBL1	3.25690925505658
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	13/1210	43/9376	2.34264847203536	ACAA2/CPT2/HADH/ECI2/ACAT1/CPT1A/ACADSB/ACSL5/ADH5/ACADM/ACOX1/EHHADH/ALDH9A1	3.39671846708783
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	44/1210	224/9376	1.52207792207792	CD3E/FOS/ATF4/ATM/TGFBR1/CD3D/CD3G/MSX1/HLA-B/CD4/CCND3/NFATC3/CDKN2C/PRKACB/JUN/PIK3CD/ANAPC4/ATR/NFYB/E2F3/SLC2A1/CDC16/TRRAP/ANAPC7/NFATC1/XPO1/ADCY9/CCNE2/SLC25A6/AKT3/ANAPC13/CCNE1/CHEK2/TP53/PTEN/TBPL1/IL2RA/VAC14/MAP3K1/EGR1/CDC20/PPP3CB/CREB3L4/BCL2L1	3.0442125141247
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	40/1210	200/9376	1.5497520661157	CLDN4/RPS3/MYO1E/CLDN3/TUBB4B/FOS/TUBA1B/PTPN6/IRAK4/ARHGEF1/TUBA1C/ARPC5L/IL18/MYO1F/TJP1/TNFSF10/JUN/MYO5A/ARHGEF12/TRADD/CLDN12/BAIAP2/MYO10/GAPDH/MYH11/RIPK1/MYO5C/CYTH4/CASP8/MYH14/TAB1/MYO6/NCKAP1/CYFIP2/WASL/FADD/MYO1D/ACTR3C/CLDN7/MYO1C	3.02502383675976
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	16/1210	62/9376	1.99968008531058	HSPA1B/HSPA1A/HSPA6/HSPA1L/SIRT1/PRKACB/CRYAB/PIK3CD/HSPA8/RPTOR/SOD1/HDAC1/ADCY9/AKT3/MTOR/SOD2	3.03992174604208
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	21/1210	90/9376	1.80804407713499	CD3E/FOS/PTPN6/MAP2K6/ZAP70/CD3D/CD3G/CD4/NFATC3/JUN/PIK3CD/LAT/ALK/NFATC1/BATF/CD28/AKT3/MTOR/PTEN/PDCD1/PPP3CB	2.96493790216823
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	29/1210	138/9376	1.62836267816505	FOS/MAP2K6/ZAP70/IRAK4/ARHGEF1/ARPC5L/IRF3/IL18/WAS/CD4/LCP2/NFATC3/JUN/PIK3CD/ARHGEF12/BAIAP2/LAT/NFATC1/TAB1/GSK3B/WASL/AKT3/RPS6KA1/CD8B/CD8A/ACTR3C/GIT2/ITGA5/SKAP2	2.86242806848058
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	18/1210	75/9376	1.85970247933884	PERP/ATM/GADD45A/CCND3/CCNG2/IGFBP3/BBC3/ATR/GADD45B/CASP8/CCNE2/CCNE1/CHEK2/DDB2/TP53/PTEN/CCNB1/BCL2L1	2.87731642124181
Genetic Information Processing	Translation	hsa03010	Ribosome	42/1210	222/9376	1.4659816841635	RPL27A/RPS15/RPS10/RPS26/RPS3/MRPL18/RPL13A/RPL37/RACK1/RPLP2/RPL8/RPL41/RPL38/RPS25/RPS13/RPS24/RPS16/RPL31/RPSA/MRPL16/RPS19/MRPS31/MRPL46/MRPL35/MRPS18B/MRPL34/RPL36A/MRPL3/MRPS18C/MRPL48/MRPS34/MRPL49/MRPS35/MRPS23/MRPS11/MRPS12/MRPL30/MRPS2/RPL22L1/MRPS28/MRPS14/MRPL43	2.70466521423142
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	21/1210	93/9376	1.74972007464676	PTPRM/PTPN6/LEF1/TGFBR1/CCM2/MET/LMO7/WAS/CDH1/TJP1/RADIL/AFDN/BAIAP2/SNAI1/CTNND1/ARHGAP29/VCL/KRIT1/WASL/CTNNA2/ERBB2	2.79685579181466
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	6/1210	15/9376	3.0995041322314	AK5/AK4/NTPCR/NFS1/AK7/TPK1	3.13238312920077
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	53/1210	300/9376	1.3689476584022	HSPA1B/HSPA1A/MECOM/HSPA6/FOS/RPS6KA5/ATF4/TGFBR1/MAP2K6/IRAK4/DDIT3/GADD45A/HSPB1/MET/HSPA1L/ERBB4/MAP3K4/EFNA5/TAOK3/NFATC3/MAP2K5/ERBB3/PRKACB/JUN/CACNA2D4/EFNA1/FLT3LG/TRADD/DUSP6/FGFR2/RRAS/HSPA8/MKNK1/GADD45B/NR4A1/PTPN7/VEGFB/NTRK1/NFATC1/TAB1/DUSP1/DAXX/AKT3/PTPRR/DUSP7/RPS6KA1/RASGRF2/TP53/MAP4K1/MAP3K1/PPP3CB/ERBB2/MAPKAPK3	2.50006774873709
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	31/1210	158/9376	1.52032639397427	SGK1/DEPTOR/EIF4B/ATP6V1E2/ATP6V1C2/STRADA/PIK3CD/ULK2/LAMTOR4/DDIT4/RPTOR/FLCN/SLC3A2/RRAGA/ATP6V1C1/LPIN3/GSK3B/DEPDC5/AKT3/CLIP1/TBC1D7/WNT2B/MTOR/RPS6KA1/CAB39L/MLST8/PTEN/MAPKAP1/FZD6/RRAGB/GRB10	2.53898235992608
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	19/1210	85/9376	1.7320758385999	ENPP3/NT5C3B/AK5/TK2/GDA/AK4/AK9/NME7/ENTPD3/NTPCR/DCTPP1/ADK/NME6/GMPS/PNP/AK7/NUDT16/NT5E/AK3	2.60980429811106
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	15/1210	63/9376	1.84494293585203	MECOM/NSD1/HADH/NSD2/ACAT1/SETDB2/PLOD2/EHMT2/EHMT1/KMT5A/CAMKMT/EHHADH/ALDH9A1/TMLHE/PIPOX	2.59015937940637
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	17/1210	75/9376	1.75638567493113	MGST1/ATM/MGST2/PIK3CD/BBC3/BRCA1/MSH3/GSTM4/CASP8/AKT3/FADD/GSTM2/TP53/BIRC5/MLH1/ERBB2/BCL2L1	2.53152802926095
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	9/1210	31/9376	2.24964009597441	DPYD/HIBCH/CNDP2/CSAD/ALDH6A1/MLYCD/ACOX1/EHHADH/ALDH9A1	2.68256207963187
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	11/1210	42/9376	2.02943722943723	SAT1/CP/SLC39A14/SLC40A1/FTL/SLC3A2/SLC39A8/TFRC/ACSL5/TP53/SLC11A2	2.57373751486366
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	14/1210	59/9376	1.83868889200168	LEF1/GADD45A/CDH1/PIK3CD/POLK/GADD45B/GSK3B/AKT3/DDB2/TP53/PTEN/CTNNA2/MLH1/ERBB2	2.4874965363274
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	10/1210	37/9376	2.094259548805	LEF1/GADD45A/CDH1/POLK/GADD45B/PAX8/NTRK1/DDB2/TP53/RXRB	2.56711104325108
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	47/1210	268/9376	1.3589243863328	MT-ATP8/MT-ND2/MT-ND4L/MT-ND1/MT-ND4/MT-ATP6/MT-CO2/MT-CYB/TUBB4B/TUBA1B/ATF4/DDIT3/TUBA1C/NDUFV3/UQCRC2/SLC39A14/CAMK2D/PRKACB/ITPR2/COX6B1/SLC18A2/ERN1/PRKN/MAOA/SOD1/XBP1/NDUFB5/TRAP1/DUSP1/ATP5MC2/SLC39A10/SLC39A8/SLC25A6/GNAL/DAXX/NDUFV1/TXN2/CALML4/NDUFB9/TP53/NDUFA3/SLC11A2/UBA7/NDUFS3/PSMA8/BCL2L1/KLC4	2.29473472760625
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	5/1210	13/9376	2.98029243483789	RAD50/DCLRE1C/XRCC4/MRE11/POLM	2.75021805207731
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	11/1210	44/9376	1.93719008264463	POLG2/APTX/PARP4/NEIL1/APEX1/MUTYH/POLD4/POLE/PARP2/NEIL3/RFC3	2.39850314899353
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	24/1210	122/9376	1.52434629454004	CD3E/TEC1/FOS/PTPN6/ZAP70/CD40LG/CD3D/CD3G/CD4/LCP2/NFATC3/JUN/PIK3CD/LAT/NFATC1/CD28/GSK3B/CARD11/AKT3/CD8B/CD8A/PDCD1/PPP3CB/PAK6	2.2439181252326
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	32/1210	174/9376	1.42505937114088	HSPA1B/HSPA1A/DNAJB1/HSPH1/HSP90AA1/ERP29/DNAJA1/HSPA6/HSP90AB1/ATF4/DDIT3/HERPUD1/UBE2D2/HSPA1L/PPP1R15A/UBXN1/CRYAB/RRBP1/P4HB/ERN1/HSPA8/PRKN/XBP1/DNAJC5/EDEM2/EDEM3/UGGT2/ERO1B/PRKCSH/MAN1A2/FBXO6/BAG2	2.17849586834096
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	14/1210	63/9376	1.72194674012856	POLR2A/ERCC5/RPA2/ERCC4/XPC/GTF2H1/GTF2H5/GTF2H2/ERCC8/DDB2/POLD4/POLE/GTF2H3/RFC3	2.21311646151607
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	20/1210	100/9376	1.5497520661157	CXCL14/CCL3L1/CCL5/CCL18/IL18/CCL20/IL10RB/IL20RA/IL6R/CX3CR1/TNFSF10/CCL4L2/CCR2/TNFRSF10D/CCR6/CCR7/IL20RB/IL2RA/IL6ST/CCL28	2.12745379086966
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	26/1210	139/9376	1.44940840715857	HSPA1B/HSPA1A/HSP90AA1/KRT19/HSPA6/KRT18/HSP90AB1/FOS/ATF4/KRT23/PLCB4/HSPA1L/PRKACB/JUN/PIK3CD/ITPR2/HSPA8/ADCY9/FKBP4/EBAG9/AKT3/HBEGF/CALML4/NCOA1/CREB3L4/SP1	2.05473943678255
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	36/1210	205/9376	1.36075791171135	ATF4/RBL2/IRF3/SYK/HLA-B/YWHAH/CCND3/DDX3X/PRKACB/JUN/PIK3CD/TRADD/GTF2B/MRPS18B/HDAC10/HDAC1/CASP8/SNW1/GTF2H1/CCNE2/GTF2H2/CCNE1/HDAC8/TP53/TBPL1/VAC14/PKM/GTF2E1/C3/CDC20/IL6ST/DNAJA3/GTF2H3/HDAC7/CREB3L4/RBL1	2.01028709012949
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	36/1210	205/9376	1.36075791171135	MT-ATP8/MT-ND2/MT-ND4L/COL1A2/MT-ND1/MT-ND4/MT-ATP6/MT-CO2/MT-CYB/PDK4/TGFBR1/NDUFV3/UQCRC2/CAMK2D/PLCB4/TBC1D4/CPT2/CD36/PIK3CD/COX6B1/GAPDH/NCF4/SLC2A1/NDUFB5/ATP5MC2/GSK3B/SLC25A6/GYS1/NDUFV1/AKT3/NDUFB9/MTOR/PTEN/NDUFA3/NDUFS3/SP1	2.01028709012949
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	25/1210	133/9376	1.45653389672528	SGK1/HOMER2/ATM/TGFBR1/DEPP1/GADD45A/S1PR4/RBL2/IL7R/KLF2/CCNG2/BCL6/SIRT1/TNFSF10/FBXO32/CDKN2D/PIK3CD/SGK3/HOMER1/GADD45B/AKT3/PLK2/PTEN/CCNB1/SOD2	2.04110810897442
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	5/1210	15/9376	2.58292011019284	SLC33A1/ST6GALNAC6/ST8SIA1/B3GALT4/HEXA	2.36165872308661
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	21/1210	109/9376	1.49288043066192	HSP90AA1/CD3E/HSP90AB1/FOS/TGFBR1/ZAP70/CD3D/CD3G/IL23A/CD4/NFATC3/IL6R/JUN/LAT/NFATC1/IL12RB1/MTOR/IL2RA/RXRB/IL6ST/PPP3CB	1.99231900733711
Cellular Processes	Cell motility	hsa04814	Motor proteins	34/1210	194/9376	1.35803016102922	MYO1E/TUBB4B/TUBA1B/TUBA1C/DNAH7/MYO1F/DNAH12/DNAH11/DYNLL1/MYO9A/MYO5A/DNAH6/MYO10/MYH11/MYO5C/STARD9/MYO19/MYL6B/DNAH5/DNAH14/KIFAP3/KIF9/MYH14/MYO6/DYNC2H1/KIF27/MYO1D/KIF2C/DNAH3/MYO1C/KIF4A/ACTA2/DNAH9/KLC4	1.93965937634703
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	22/1210	117/9376	1.45703185703186	MORF4L2/DPF3/BICRAL/MTA2/SMARCA2/INO80E/CECR2/PHF6/HDAC1/TRRAP/TFPT/UCHL5/MTA3/GATAD2A/VPS72/DMAP1/BRD8/MRGBP/MCRS1/SMARCE1/ACTR6/ACTR8	1.91483341534639
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	6/1210	21/9376	2.21393152302243	ENPP3/PPCDC/DPYD/CSAD/COASY/PPCS	2.14365838091216
Organismal Systems	Digestive system	hsa04978	Mineral absorption	13/1210	61/9376	1.65137515241837	MT1G/MT1F/SLC34A2/VDR/MT1E/MT2A/MT1X/SLC40A1/MT1M/FTL/MT1H/SLC26A3/SLC11A2	1.96461887071634
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	25/1210	138/9376	1.40376092945263	YWHAH/CAMK2D/PRKACB/SPDYA/ANAPC4/ITPR2/CDC16/ANAPC7/AURKA/ADCY9/CCNE2/CPEB4/SPDYE1/CPEB3/ANAPC13/BUB1/FBXO5/CCNE1/CALML4/RPS6KA1/CDC20/CCNB1/PPP3CB/CDC25C/BTRC	1.83928272251307
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	9/1210	38/9376	1.83523270987386	ENPP3/NMRK2/SIRT1/SIRT5/QPRT/PNP/NT5E/NMRK1/SIRT6	1.98584795120635
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	9/1210	38/9376	1.83523270987386	CD3E/ZAP70/CD40LG/CD3D/IL7R/CD4/DCLRE1C/CD8B/CD8A	1.98584795120635
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	50/1210	308/9376	1.25791563808093	MT-ATP8/MT-ND2/MT-ND4L/MT-ND1/MT-ND4/MT-ATP6/MT-CO2/MT-CYB/TUBB4B/TUBA1B/TUBA1C/NDUFV3/POLR2A/DNAH7/UQCRC2/GPX3/DNAH12/DNAH11/PLCB4/BBC3/HIP1/DNAH6/COX6B1/REST/ERN1/DNAH5/DNAH14/CLTA/ULK2/SOD1/HDAC1/CASP8/NDUFB5/TFAM/ATP5MC2/SLC25A6/NDUFV1/NDUFB9/MTOR/TP53/TBPL1/DNAH3/NDUFA3/SOD2/NDUFS3/PSMA8/CREB3L4/DNAH9/SP1/KLC4	1.77162138275137
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	18/1210	93/9376	1.49976006398294	GADD45A/PIK3CD/LAMA5/E2F3/POLK/GADD45B/CKS2/FHIT/CCNE2/AKT3/CCNE1/DDB2/TP53/PTEN/RXRB/ITGA2/LAMC1/BCL2L1	1.86437161913653
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	10/1210	44/9376	1.7610818933133	MGAT4A/B4GALNT3/FUT8/ST3GAL3/MGAT1/CHST9/HEXA/MGAT2/ALG11/MAN1A2	1.94779837255928
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	10/1210	44/9376	1.7610818933133	TAF7/GTF2B/GTF2H1/GTF2H5/TAF12/GTF2H2/TBPL1/GTF2E1/TAF8/GTF2H3	1.94779837255928
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	11/1210	50/9376	1.70472727272727	CKB/SAT1/P4HA1/ARG2/AMD1/CNDP2/MAOA/AZIN2/P4HA2/GOT1/ALDH9A1	1.92323348173455
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	12/1210	56/9376	1.66044864226682	MGAT4A/FUT8/MGAT5/ST6GAL1/MGAT1/DHRSX/ALG8/MGAT2/ALG11/MAN1A2/ALG6/MGAT3	1.90808951285237
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	17/1210	87/9376	1.51412558183718	FOS/LEF1/TGFBR1/GADD45A/JUN/PIK3CD/BBC3/MSH3/POLK/GADD45B/GSK3B/AKT3/MTOR/DDB2/TP53/BIRC5/MLH1	1.85446223855938
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	19/1210	100/9376	1.47226446280992	CD3E/CD24/CD2/CD37/CD3D/IL7R/CD59/CD3G/CD4/IL6R/CD36/FLT3LG/TFRC/EPOR/CD8B/IL2RA/CD8A/ITGA5/ITGA2	1.82758898715358
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	36/1210	214/9376	1.30352977523751	CD3E/FOS/ATM/MAP2K6/IRAK4/CD3D/CGAS/IRF3/CD3G/HLA-B/CD4/NFATC3/JUN/APOBEC3H/GNG11/PIK3CD/TRADD/ITPR2/ATR/RIPK1/APOBEC3D/CASP8/NFATC1/TAB1/AKT3/FADD/AP1M2/CALML4/MTOR/CCNB1/PPP3CB/WEE1/CDC25C/PAK6/BTRC/BCL2L1	1.72896689910603
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	5/1210	17/9376	2.2790471560525	PAPSS1/SEPHS2/SEPHS1/KYAT3/SEPSECS	2.0317484121079
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	7/1210	28/9376	1.93719008264463	ACAA2/TECR/THEM4/HADH/MBLAC2/ELOVL6/MECR	1.91170547354377
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	7/1210	28/9376	1.93719008264463	ST3GAL3/ST3GAL6/B3GNT4/ST8SIA1/GCNT2/B3GALNT1/B4GALT4	1.91170547354377
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	23/1210	128/9376	1.39235537190083	ENPP3/PAPSS1/AK5/GDA/AK4/AK9/NME7/ENTPD3/NTPCR/ADK/NME6/GMPS/FHIT/ADCY9/PNP/NUDT9/PFAS/AK7/HDDC3/NUDT16/NT5E/AK3/PDE6D	1.72041932786122
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	25/1210	142/9376	1.3642183680596	HSP90AA1/MGST1/HSP90AB1/FOS/MAP2K6/MEF2A/KLF2/MGST2/MAP2K5/JUN/PECAM1/PIK3CD/GSTM4/BMPR1B/CTSL/DUSP1/SDC2/VCAM1/AKT3/SQSTM1/GSTM2/BMPR1A/TXN2/CALML4/TP53	1.6833898984142
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	15/1210	77/9376	1.50949876569711	TGFBR1/GADD45A/PLD1/PIK3CD/E2F3/POLK/GADD45B/ARHGEF6/AKT3/MTOR/DDB2/BRCA2/TP53/ERBB2/BCL2L1	1.72800108377034
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	6/1210	23/9376	2.02141573841179	MSH3/RPA2/MLH3/POLD4/MLH1/RFC3	1.88783760042811
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	14/1210	71/9376	1.52792457222675	MET/PIK3CD/FGFR2/SLC2A1/NTRK1/HKDC1/AKT3/LDHC/MTOR/TP53/PTEN/PKM/SIRT6/ERBB2	1.71876498621234
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	5/1210	18/9376	2.1524334251607	CBR4/HSD17B8/OXSM/ACSL5/MECR	1.88379748934139
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	5/1210	18/9376	2.1524334251607	FUCA1/NEU1/ENGASE/HEXA/FUCA2	1.88379748934139
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	9/1210	41/9376	1.70094738963919	DAPK2/RPS6KA5/CDH1/RASSF1/DAPK1/E2F3/HBEGF/TP53/ERBB2	1.73138569719272
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	44/1210	275/9376	1.23980165289256	MT-ATP8/HSPA1B/HSPA1A/MT-ND2/MT-ND4L/HSPA6/MT-ND1/MT-ND4/MT-ATP6/MT-CO2/MT-CYB/TUBB4B/TUBA1B/ATF4/DDIT3/TUBA1C/NDUFV3/CCL5/NCAM1/UQCRC2/STIP1/HSPA1L/PRKACB/PIK3CD/ITPR2/COX6B1/HSPA8/NCF4/SOD1/NDUFB5/ATP5MC2/GSK3B/SLC25A6/NDUFV1/NOTCH1/NDUFB9/EGR1/NDUFA3/PPP3CB/LAMC1/NDUFS3/PSMA8/CREB3L4/KLC4	1.55362999587545
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	40/1210	248/9376	1.24980005331911	HSP90AA1/RPS3/HSP90AB1/TUBB4B/FOS/TUBA1B/LEF1/MAP2K6/IRAK4/ANXA2/TUBA1C/ARPC5L/IL18/AHNAK/DYNLL1/VPS41/TNFSF10/JUN/PIK3CD/TRADD/GAPDH/RRAS/RIPK1/CYTH4/CASP8/TAB1/MYO6/NCKAP1/CYFIP2/WASL/STX10/AKT3/FADD/TXN2/DYNC2H1/ACTR3C/SNX18/TLR6/MLKL/KLC4	1.53463177803025
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	14/1210	73/9376	1.48606362504245	GADD45A/MET/RASSF1/PIK3CD/E2F3/POLK/ALK/GADD45B/FHIT/AKT3/DDB2/TP53/RXRB/ERBB2	1.60478433612784
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	56/1210	362/9376	1.19870325555911	HSP90AA1/SPP1/COL1A2/SGK1/HSP90AB1/ATF4/RBL2/MET/IFNAR2/ITGB8/IL7R/EIF4B/SYK/YWHAH/CCND3/ERBB4/EFNA5/IL6R/ERBB3/THEM4/EFNA1/GNG11/FLT3LG/PIK3CD/SGK3/PHLPP1/MAGI1/BRCA1/LAMA5/FGFR2/DDIT4/RPTOR/NR4A1/VEGFB/NTRK1/PIK3R6/COL9A2/GSK3B/CCNE2/GYS1/AKT3/EPOR/CCNE1/MTOR/MLST8/TP53/PTEN/IL2RA/ITGA5/ITGA2/LAMC1/ERBB2/CREB3L4/LPAR3/VWF/BCL2L1	1.48413745897529
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	7/1210	30/9376	1.80804407713499	PIGF/GPAA1/PIGN/B3GALT4/PIGC/PIGL/PIGZ	1.70630406677552
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	8/1210	36/9376	1.72194674012856	ENPP3/PYGL/AGL/HKDC1/GYS1/PYGM/GANC/UGP2	1.67053895589893
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	8/1210	36/9376	1.72194674012856	RNASEH2B/RPA2/DNA2/POLD4/POLE/MCM3/POLA1/RFC3	1.67053895589893
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	17/1210	93/9376	1.41644006042833	CD3E/MAML3/FOS/ZAP70/CD3D/CD3G/MAML2/CD4/NFATC3/JUN/LAT/MAF/NFATC1/IL12RB1/NOTCH1/IL2RA/PPP3CB	1.55354356157716
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	27/1210	160/9376	1.30760330578512	CD2/CLDN4/PTPRM/CLDN3/ALCAM/CD40LG/ITGB8/NCAM1/CDH1/HLA-B/NRXN3/CD4/PECAM1/CD226/CLDN12/F11R/CD28/SDC2/VCAM1/ICAM2/CXADR/IGSF11/CADM1/CD8B/CD8A/CLDN7/PDCD1	1.51061360700857
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	40/1210	250/9376	1.23980165289256	MEAK7/DEPTOR/ATP6V1E2/CTSF/FUCA1/VPS41/ATP6V1C2/WDR7/NEU1/DNASE2/CLN3/CLTA/TPCN1/LAMTOR4/RPTOR/SPG11/BORCS6/CTSL/DTNBP1/RRAGA/ATP6V1C1/GM2A/ABCB9/CTSB/CTSH/HEXA/AP4B1/LGMN/AP1M2/MTOR/MLST8/VPS13A/SLC11A2/RRAGB/FUCA2/ZFYVE26/FIG4/OSBPL5/AP3M2/SLC17A5	1.47929769293019
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	5/1210	19/9376	2.0391474554154	LIPT1/AMT/LIAS/BCKDHB/DBT	1.74525664315747
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	26/1210	154/9376	1.30823226360416	UGT2B7/PPCDC/AK5/AK4/COQ7/AK9/NME7/ALAS1/NFS1/COASY/COQ5/PMM1/NME6/IDO2/QPRT/LIPT1/OXSM/LIAS/COX10/UGP2/AK7/PPCS/TPK1/MTHFD2/AFMID/AK3	1.48456607773329
NA	NA	hsa04518	Integrin signaling	26/1210	154/9376	1.30823226360416	SPP1/ITGAD/COL1A2/FREM2/MET/ITGB8/ITGAX/CDH1/CCND3/PIK3CD/LAMA5/VCL/VEGFB/COL9A2/GSK3B/ARHGEF6/VCAM1/AKT3/ICAM2/MTOR/ITGA5/C3/ITGA2/LAMC1/ERBB2/VWF	1.48456607773329
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	11/1210	55/9376	1.5497520661157	SGPP2/NEU1/PLPP2/GM2A/KDSR/SPHK2/UGCG/HEXA/ACER2/B4GALT6/CERS4	1.57394878459422
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	19/1210	107/9376	1.37594809608403	ATF4/CAMK2D/PLCB4/SIRT1/PRKACB/ITPR2/PYGL/SLC2A1/CPT1A/GYS1/PYGM/AKT3/LDHC/FBP1/CALML4/PKM/PPP3CB/CREB3L4/PHKA2	1.50548687311746
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	25/1210	148/9376	1.30891221800313	FOS/LEF1/GADD45A/FRAT2/JUN/PIK3CD/BRCA1/TNFSF11/E2F3/POLK/GADD45B/GSK3B/AKT3/NOTCH1/WNT2B/MTOR/DDB2/BRCA2/TP53/PTEN/NCOA1/FZD6/HES1/ERBB2/SP1	1.45809488367294
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	7/1210	31/9376	1.74972007464676	PCCA/GRHPR/HYI/ACAT1/MCEE/AMT/AFMID	1.60939989767051
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	28/1210	169/9376	1.28381827962248	DAPK2/C9orf72/DEPTOR/VPS41/DAPK1/PRKACB/PIK3CD/IGBP1/ERN1/RRAS/SMCR8/ULK2/CFLAR/DDIT4/RPTOR/CTSL/WDFY3/ATG4C/RRAGA/CTSB/AKT3/SQSTM1/SUPT20H/MTOR/MLST8/PTEN/RRAGB/BCL2L1	1.43317188381643
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	24/1210	142/9376	1.30964963333721	HERC4/SOCS1/UBE2D2/UBE2Q1/ANAPC4/BRCA1/PRKN/FBXW8/CDC16/ANAPC7/PPIL2/MID1/WWP2/UBE2E3/ANAPC13/PRPF19/ERCC8/DDB2/MAP3K1/FBXO4/CDC20/UBA7/BTRC/PIAS2	1.43117731152491
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	11/1210	56/9376	1.52207792207792	HSPA1B/HSPA1A/HSPA6/HSPD1/IL18/EEF1G/HSPA1L/HSPA8/CASP8/BCL2L13/C3	1.50832531745319
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	56/1210	368/9376	1.17915918074021	MT-ATP8/MT-ND2/MT-ND4L/MT-ND1/MT-ND4/MT-ATP6/MT-CO2/MT-CYB/TUBB4B/TUBA1B/SRSF3/ATF4/C9orf72/MAP2K6/DDIT3/TUBA1C/NDUFV3/DNAH7/UQCRC2/GPX3/DNAH12/DNAH11/ERBB4/NUP210L/DNAH6/COX6B1/FUS/ERN1/SMCR8/PRKN/DNAH5/DNAH14/ULK2/SPG11/SOD1/XBP1/NDUFB5/ATP5MC2/DAXX/NDUFV1/SQSTM1/GLE1/NDUFB9/MTOR/TP53/NUP62/DNAH3/NUP37/NDUFA3/PPP3CB/FIG4/NDUFS3/PSMA8/DNAH9/BCL2L1/KLC4	1.34965393107142
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	25/1210	150/9376	1.29146005509642	LEF1/TGFBR1/GADD45A/MET/CDH1/FRAT2/JUP/PIK3CD/FGFR2/E2F3/POLK/GADD45B/GSK3B/CCNE2/AKT3/CCNE1/WNT2B/MTOR/DDB2/TP53/CTNNA2/RXRB/FZD6/MLH1/ERBB2	1.3851333393768
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	8/1210	38/9376	1.63131796433232	GALK2/GNPDA1/FPGT/PMM1/GNPDA2/HKDC1/HEXA/UGP2	1.50102057930471
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	18/1210	103/9376	1.35415229078071	CD3E/FOS/CCL3L1/TGFBR1/IRAK4/CCL5/CD3D/CD3G/PLCB4/JUN/PIK3CD/CFLAR/CASP8/GNAL/AKT3/FADD/C3/TLR6	1.39114427662698
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	19/1210	110/9376	1.33842223891811	HSP90AA1/HSP90AB1/PRKACB/SPDYA/PIK3CD/ANAPC4/CDC16/ANAPC7/AURKA/ADCY9/CPEB4/SPDYE1/AKT3/CPEB3/ANAPC13/BUB1/RPS6KA1/CCNB1/CDC25C	1.37430372784588
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	37/1210	235/9376	1.22001758396343	MT-ATP8/MT-ND2/MT-ND4L/MT-ND1/MT-ND4/MT-ATP6/MT-CO2/MT-CYB/SLC25A29/DPF3/NDUFV3/UQCRC2/PRKACB/CPT2/COX6B1/SMARCA2/RPTOR/CPT1A/NDUFB5/KDM3A/ADCY9/ATP5MC2/COA6/NDUFV1/ACSL5/PNPLA2/NDUFB9/MTOR/COX10/RPS6KA1/MLST8/SMARCE1/NDUFA3/LIPE/SIRT6/NDUFS3/CREB3L4	1.31482545542509
NA	NA	hsa04517	IgSF CAM signaling	46/1210	299/9376	1.19211697393516	CD2/GRIP1/TUBB4B/TUBA1B/PTPN6/TUBA1C/ARPC5L/SLIT2/NCAM1/ITGAX/LMO7/CDH1/MBP/DYNLL1/TJP1/LCP2/SLAMF1/TRIO/PIK3CD/ANK3/CSK/CD226/MAGI1/AFDN/SLAMF6/BAIAP2/SRGAP3/F11R/MYH11/TJP2/MYL6B/VCL/DOK2/MYH14/CD28/GSK3B/CABLES1/WASL/AKT3/ICAM2/CXADR/CADM1/ACTR3C/ANK2/ITGA5/PAK6	1.29958233488407
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	7/1210	33/9376	1.64367643375908	STX3/STX18/VTI1A/GOSR1/STX16/BET1/SNAP23	1.42578827886024
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	18/1210	105/9376	1.32835891381346	ATM/ZAP70/CD40LG/IRAK4/GADD45A/SYK/CCL4L2/TRADD/EDA/TNFSF11/LAT/RIPK1/CFLAR/GADD45B/TAB1/CARD11/VCAM1/BCL2L1	1.30242824202036
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	6/1210	27/9376	1.72194674012856	BDH1/HADH/HMGCL/ACAT1/L2HGDH/EHHADH	1.44603264490252
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	39/1210	253/9376	1.19447293633424	RPS6KA5/ATM/TIFA/FNBP1L/ARPC5L/CCL5/CGAS/IRF3/IL18/UBE2D2/PLCB4/JUN/PIK3CD/TRADD/ITPR2/PPID/RIPK1/SEPTIN11/RPTOR/CYTH4/VCL/TAB1/RRAGA/HKDC1/GSK3B/UBE2V2/WASL/AKT3/SQSTM1/MTOR/TECPR1/TP53/ACTR3C/ITGA5/C3/SHARPIN/RRAGB/BTRC/BCL2L1	1.20704713720857
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	18/1210	106/9376	1.31582722594729	HSP90AA1/HSP90AB1/ATF4/LEF1/SPINT1/PIK3CD/FGFR2/E2F3/GSK3B/CCNE2/AKT3/CCNE1/MTOR/TP53/PTEN/SLC19A1/ERBB2/CREB3L4	1.2587406767876
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	9/1210	47/9376	1.48380516968525	ACYP2/GRHPR/ACAT1/ME2/LDHC/ADH5/PKM/GLO1/ALDH9A1	1.27989847818697
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	26/1210	163/9376	1.23599858033768	SLC10A1/FOS/ATF4/TGFBR1/MAP2K6/IRAK4/IRF3/NFATC3/CASP10/DDX3X/JUN/PIK3CD/E2F3/CASP8/NFATC1/TAB1/MAVS/CCNE2/AKT3/FADD/CCNE1/DDB2/TP53/MAP3K1/BIRC5/CREB3L4	1.16997422087987
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	35/1210	227/9376	1.19474278224779	MT-ATP8/MT-ND2/MT-ND4L/SLC26A2/MT-ND1/MT-ND4/MT-ATP6/MT-CO2/MT-CYB/MGST1/FOS/NDUFV3/MET/PLD1/UQCRC2/MGST2/JUN/PIK3CD/COX6B1/CBR1/PRKD2/GSTM4/SOD1/NDUFB5/EPHX1/ATP5MC2/SLC25A6/NDUFV1/AKT3/GSTM2/NDUFB9/PTEN/NDUFA3/SOD2/NDUFS3	1.1433024147244
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	10/1210	54/9376	1.4349556167738	MTAP/AMD1/AHCY/ADI1/TST/KYAT3/AHCYL2/LDHC/GOT1/SDSL	1.23384586402798
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	19/1210	115/9376	1.2802299676608	SGK1/SLC34A2/FOS/ATF4/VDR/ARHGEF1/MEF2A/PLD1/PLCB4/PRKACB/ITPR2/TNFSF11/ADCY9/HBEGF/EGR1/RXRB/RUNX2/CREB3L4/SP1	1.16387995964651
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	18/1210	109/9376	1.27961179771021	SPP1/FOS/CCL3L1/MAP2K6/IRAK4/CCL5/IFNAR2/IRF3/JUN/CCL4L2/PIK3CD/TLR1/RIPK1/CASP8/TAB1/AKT3/FADD/TLR6	1.13024552122232
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	19/1210	116/9376	1.26919350242234	PCCA/HIBCH/GAPDH/ENO2/ALDH6A1/SUCLG2/ACAT1/MCEE/HKDC1/ME2/TPI1/AMT/FBP1/ADH5/GOT1/PKM/ACOX1/SDSL/GPT2	1.12295333653557
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	23/1210	144/9376	1.2376492194674	SCD5/LEF1/MAP2K6/IRAK4/IRF3/SIRT1/TRADD/RIPK1/CPT1A/C3AR1/CASP8/TAB1/LPIN3/GSK3B/TRA2B/AKT3/FADD/MLYCD/ADH5/ACADM/ACOX1/C3/ALDH9A1	1.10622476290083
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	8/1210	42/9376	1.47595434868162	HADH/MAOA/ACAT1/IDO2/KYAT3/EHHADH/AFMID/ALDH9A1	1.18995265329005
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	5/1210	23/9376	1.68451311534315	ST3GAL3/FKTN/RXYLT1/B3GAT1/CRPPA	1.26515536087228
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	5/1210	23/9376	1.68451311534315	PDSS2/PMVK/GGPS1/ACAT1/PCYOX1	1.26515536087228
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	29/1210	187/9376	1.20167940955496	TXNIP/HSP90AA1/HSP90AB1/IRAK4/CCL5/IFNAR2/GBP3/IRF3/IL18/CARD8/PLCB4/JUN/ITPR2/RIPK1/IRGM/CASP8/GPSM3/TAB1/ERBIN/BRCC3/RNASEL/MAVS/ANTXR2/CTSB/GBP7/FADD/TXN2/SHARPIN/BCL2L1	1.07231374854824
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	4/1210	17/9376	1.823237724842	PCDH7/MYH11/MYH14/TFRC	1.30770154354371
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	11/1210	62/9376	1.37478005865103	MAML3/MAML2/CTBP2/NRARP/HDAC1/SNW1/NOTCH1/APH1B/HES1/RFNG/MFNG	1.13966664637739
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	22/1210	138/9376	1.23530961791831	MT-ATP8/MT-ND2/MT-ND4L/MT-ND1/MT-ND4/MT-ATP6/MT-CO2/MT-CYB/NDUFV3/UQCRC2/ATP6V1E2/ATP6V1C2/PPA2/COX6B1/NDUFB5/ATP6V1C1/ATP5MC2/NDUFV1/NDUFB9/COX10/NDUFA3/NDUFS3	1.07192371303743
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	12/1210	69/9376	1.34761049227452	FOS/ATF4/CAMK2D/SIRT1/PRKACB/JUN/SLC18A2/MAOA/HDAC1/CALML4/PPP3CB/CREB3L4	1.1155427054518
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	11/1210	63/9376	1.35295815295815	LEF1/GADD45A/GLI1/POLK/GADD45B/SUFU/GSK3B/WNT2B/DDB2/TP53/FZD6	1.08198770784518
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	13/1210	77/9376	1.30823226360416	MECOM/TGFBR1/GADD45A/CTBP2/PIK3CD/E2F3/POLK/GADD45B/HDAC1/AKT3/DDB2/TP53/BCL2L1	1.04539151303384
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	19/1210	119/9376	1.23719702757136	FOS/RPS6KA5/ATF4/MAP2K6/CCL5/CCL20/CASP10/JUN/PIK3CD/TRADD/RIPK1/CFLAR/CASP8/TAB1/VCAM1/AKT3/FADD/CREB3L4/MLKL	1.00235422839595
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	18/1210	112/9376	1.24533648170012	HSPA1B/HSPA1A/HSPA6/MAP2K6/CD40LG/IRAK4/SOCS1/HSPA1L/IL10RB/LAMA5/HSPA8/IRGM/CASP8/TAB1/PIK3R6/AKT3/LAMC1/BCL2L1	1.0054153387536
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	7/1210	37/9376	1.4659816841635	HGD/LRTOMT/MIF/MAOA/ADH5/GOT1/GSTZ1	1.09318372288843
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	7/1210	37/9376	1.4659816841635	GALK2/FPGT/PMM1/CMAS/HKDC1/UGP2/TGDS	1.09318372288843
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	31/1210	205/9376	1.17176375730699	CD3E/MAP2K6/IRAK4/GADD45A/IFNAR2/CD3D/IRF3/SYK/CD3G/HLA-B/CCND3/JUN/PIK3CD/TRADD/ENTPD3/RIPK1/E2F3/POLK/GADD45B/HDAC1/CASP8/TAB1/SNW1/MAVS/CCNE2/AKT3/FADD/CCNE1/DDB2/TP53/HES1	0.957136219766859
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	34/1210	227/9376	1.16060727418357	ATF4/CCL3L1/MAP2K6/ARHGEF1/CCL5/CGAS/IRF3/PTGER2/HLA-B/PLCB4/NFATC3/IL10RB/IL6R/PRKACB/GNG11/CCL4L2/PIK3CD/ARHGEF12/TRADD/ITPR2/RIPK1/E2F3/CASP8/NFATC1/ADCY9/GSK3B/AKT3/FADD/CALML4/MTOR/TP53/PPP3CB/CREB3L4/SP1	0.942898536607816
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	26/1210	170/9376	1.1851045211473	CLDN4/PATJ/HSPA4/CLDN3/TUBA1B/TUBA1C/ARPC5L/WAS/TJP1/PRKACB/JUN/MAGI1/AFDN/CLDN12/F11R/MYH11/TJP2/MYL6B/MYH14/TJP3/MICALL2/DLG2/ACTR3C/MAP3K1/CLDN7/ERBB2	0.937518048904233
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	37/1210	250/9376	1.14681652892562	HSPA1B/HSPA1A/HSPA6/TGFBR1/ARAP2/ARPC5L/ACAP1/PLD1/PSD4/HLA-B/HSPA1L/WASHC3/SNX5/FGFR2/HSPA8/CLTA/CYTH4/VPS25/CHMP4C/VPS45/LDLRAP1/WASHC5/CHMP3/TFRC/WASL/EHD1/RUFY1/IL2RA/ACTR3C/GIT2/RUFY2/STAMBP/AMPH/ZFYVE9/CHMP1B/MVB12A/SNX2	0.905687470890755
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	24/1210	157/9376	1.18452387219035	CD24/SGK1/PTPN6/ABCA1/PTGER2/HAVCR1/ARG2/CAMK2D/VPS41/NFATC3/SIRT1/CX3CR1/PECAM1/CD36/ANO5/SLC2A1/GULP1/CPT1A/XKR6/NFATC1/VPS8/SPHK2/EPOR/DUSP7	0.897499290404044
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	8/1210	45/9376	1.37755739210285	KIR2DL3/KIR2DL1/KIR3DL1/HLA-B/KIR3DL2/CD28/PRF1/KLRD1	0.977234465331315
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	48/1210	333/9376	1.11693842602934	SPP1/COL1A2/PATJ/MAML3/ATM/RBL2/IFNAR2/ITGB8/IRF3/ATP6V1E2/HLA-B/MAML2/CCND3/ATP6V1C2/TADA3/PRKACB/PIK3CD/MAGI1/TRADD/ATR/LAMA5/HDAC1/CASP8/COL9A2/ATP6V1C1/GSK3B/CCNE2/AKT3/FADD/NOTCH1/CCNE1/DLG2/WNT2B/MTOR/TP53/PTEN/TBPL1/PKM/FZD6/ITGA5/HES1/ITGA2/LAMC1/RFNG/CREB3L4/MFNG/VWF/RBL1	0.836366695929592
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	10/1210	59/9376	1.31334920857263	ENPP3/NT5C3B/DPYD/TK2/AK9/NME7/ENTPD3/DCTPP1/NME6/NT5E	0.929373309243478
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	6/1210	32/9376	1.45289256198347	IGBP1/ULK2/RPTOR/ATG4C/MTOR/MLST8	0.987819051757505
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	35/1210	238/9376	1.13952357802625	RPL27A/RPS15/RPS10/RPS26/RPS3/RPL13A/RPL37/FOS/RPLP2/RPL8/RPL41/RPL38/IRAK4/RPS25/RPS13/RPS24/IFNAR2/CGAS/IRF3/RPS16/SYK/RPL31/RPSA/RPS19/IL6R/JUN/PIK3CD/RPL36A/C3AR1/MAVS/HBEGF/C3/RPL22L1/IL6ST/VWF	0.839236071736034
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	17/1210	109/9376	1.20852225339298	TBC1D4/SLC27A4/CD36/PIK3CD/PYGL/SLC2A1/CPT1A/GSK3B/GYS1/PYGM/AKT3/TRIB3/MTOR/RPS6KA1/PTEN/MLX/CREB3L4	0.842887692517386
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	4/1210	20/9376	1.5497520661157	CMAS/UGP2/TGDS/CYB5R1	0.9473498638958
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	21/1210	140/9376	1.16231404958678	SPP1/TGFBR1/MEF2A/CDH1/KLF2/PLCB4/PRKACB/GNG11/ITPR2/RRAS/PIK3R6/ADCY9/TFAM/SPHK2/AKT3/CALML4/MTOR/EGR1/LIPE/MEF2B/ACTA2	0.74482081386927
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	20/1210	133/9376	1.16522711738023	KIR2DL3/KIR2DL1/PTPN6/ZAP70/KIR3DL1/IFNAR2/SYK/HLA-B/LCP2/TNFSF10/KIR3DL2/PIK3CD/KIR2DL4/LAT/NCR1/NFATC1/ICAM2/PRF1/KLRD1/PPP3CB	0.738710556929765
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/1210	14/9376	1.66044864226682	FUT8/ST3GAL3/B4GALT4	0.951902323108352
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	6/1210	34/9376	1.3674282936315	DBP/CLOCK/PER3/NPAS2/NR1D1/BTRC	0.826163033196996
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	25/1210	170/9376	1.13952357802625	MGST1/LEF1/TGFBR1/GADD45A/DPF3/MET/MGST2/FRAT2/PIK3CD/E2F3/GSTM4/POLK/SMARCA2/GADD45B/GSK3B/AKT3/GSTM2/WNT2B/MTOR/DDB2/TP53/PTEN/SMARCE1/FZD6/BCL2L1	0.706659523152418
Human Diseases	Cancer: specific types	hsa05214	Glioma	12/1210	76/9376	1.22348847324924	GADD45A/CAMK2D/PIK3CD/E2F3/POLK/GADD45B/AKT3/CALML4/MTOR/DDB2/TP53/PTEN	0.752998456684615
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	16/1210	105/9376	1.1807634789453	ATF4/FKBP8/CITED2/MTX2/JUN/RRAS/PRKN/PHB2/FUNDC1/BCL2L13/SQSTM1/TP53/MUL1/RHOT1/SP1/BCL2L1	0.716994271207621
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	26/1210	178/9376	1.13184139660136	CACYBP/LEF1/CCDC88C/LGR4/CAMK2D/CCND3/PLCB4/FRAT2/NFATC3/SIRT1/SOX17/PRKACB/JUN/CTBP2/INVS/CELSR1/NFATC1/NKD1/GSK3B/CBY1/BAMBI/WNT2B/TP53/FZD6/PPP3CB/BTRC	0.683579026030105
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	29/1210	201/9376	1.11798034620287	ATM/DDIT3/GADD45A/FUT8/PBX3/MET/SIX4/BCL6/CDKN2C/SPINT1/JUP/IGFBP3/FUS/DUSP6/ATF1/FLI1/POLK/NSD2/GADD45B/HDAC1/PAX8/NTRK1/MAF/DDB2/TP53/RXRB/RUNX2/SP1/BCL2L1	0.650846080867258
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	23/1210	157/9376	1.13516871084908	MT-CO2/MT-CYB/FOS/ATF4/DDIT3/NDUFV3/UQCRC2/IL6R/JUN/PIK3CD/COX6B1/LEPR/ERN1/XBP1/CASP8/NDUFB5/GSK3B/NDUFV1/AKT3/NDUFB9/MLX/NDUFA3/NDUFS3	0.657442425372141
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	9/1210	56/9376	1.24533648170012	PRKACB/GLI1/DISP1/SUFU/SPOP/GSK3B/CSNK1G1/EFCAB7/BTRC	0.708796926654848
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	6/1210	35/9376	1.32835891381346	FPGT/PMM1/SORD/HKDC1/TPI1/FBP1	0.749134472270394
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	12/1210	78/9376	1.19211697393516	PIP4K2A/PLCB4/INPP5F/PIK3CD/ALDH6A1/PPIP5K2/MTM1/TPI1/PLCH1/PLCH2/PTEN/FIG4	0.655830942912756
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	12/1210	78/9376	1.19211697393516	ZCCHC7/TOB1/HSPD1/ENO2/PARN/EXOSC8/EXOSC9/DCP1B/DIS3L/EXOSC4/EXOSC3/NUDT16	0.655830942912756
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	12/1210	78/9376	1.19211697393516	ARPC5L/MET/SEPTIN1/CDH1/PIK3CD/CLTA/SEPTIN11/VCL/WASL/CTNNA2/ACTR3C/ITGA5	0.655830942912756
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	14/1210	93/9376	1.16648004976451	ATF4/MAP2K6/PLD1/CAMK2D/PLCB4/MAP3K4/PRKACB/JUN/ITPR2/ADCY9/HBEGF/CALML4/MAP3K1/EGR1	0.621059388899033
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	4/1210	22/9376	1.40886551465064	CNDP2/MAOA/CARNMT1/ALDH9A1	0.739038009446521
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	8/1210	50/9376	1.23980165289256	HBA1/CD40LG/MET/IL18/PECAM1/CD36/SDC2/VCAM1	0.654429856295262
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	13/1210	86/9376	1.17132423601768	DSP/SGCD/LEF1/ITGB8/SNTB1/JUP/DSC2/CACNA2D4/DSG2/PKP2/CTNNA2/ITGA5/ITGA2	0.614375386012308
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	6/1210	36/9376	1.29146005509642	UGT2B7/FGGY/SORD/DCXR/UGP2/CRPPA	0.674420077082575
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	8/1210	51/9376	1.21549181656134	ATP6V1E2/ATP6V1C2/TJP1/PRKACB/TJP2/KCNQ1/ADCY9/ATP6V1C1	0.593970786698225
Human Diseases	Cancer: specific types	hsa05218	Melanoma	11/1210	73/9376	1.16762141967621	GADD45A/MET/CDH1/PIK3CD/E2F3/POLK/GADD45B/AKT3/DDB2/TP53/PTEN	0.553417731418194
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	3/1210	16/9376	1.45289256198347	MIF/MAOA/GOT1	0.697896291700943
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	3/1210	16/9376	1.45289256198347	ST8SIA1/HEXA/B3GALNT1	0.697896291700943
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	16/1210	110/9376	1.12709241172051	EGLN3/CAMK2D/IL6R/PIK3CD/EPAS1/GAPDH/MKNK1/ENO2/SLC2A1/TIMP1/HKDC1/TFRC/AKT3/LDHC/MTOR/ERBB2	0.516111399081808
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	4/1210	23/9376	1.34761049227452	ARG2/GOT1/ACY1/GPT2	0.642473121316454
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	65/1210	480/9376	1.04931129476584	MT-ATP8/MT-ND2/MT-ND4L/MT-ND1/MT-ND4/MT-ATP6/MT-CO2/MT-CYB/TUBB4B/TUBA1B/ATF4/C9orf72/MAP2K6/DDIT3/TUBA1C/NDUFV3/DNAH7/UQCRC2/GPX3/DNAH12/CAMK2D/DNAH11/PLCB4/FRAT2/HIP1/DNAH6/ITPR2/COX6B1/FUS/PPID/ERN1/CHRM3/SMCR8/PRKN/DNAH5/DNAH14/ULK2/SPG11/SOD1/XBP1/CASP8/NDUFB5/TRAP1/ATP5MC2/GSK3B/SLC25A6/DAXX/NDUFV1/FADD/SQSTM1/CALML4/NDUFB9/WNT2B/MTOR/FZD6/DNAH3/NDUFA3/UBA7/PPP3CB/FIG4/NDUFS3/PSMA8/DNAH9/BCL2L1/KLC4	0.426916827141904
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	7/1210	45/9376	1.20536271808999	DEFB1/ABCA1/ABCA10/ABCD2/ABCA7/ABCB9/ABCD3	0.531541774070181
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	10/1210	67/9376	1.15653139262366	GAPDHS/GAPDH/ENO2/HKDC1/TPI1/LDHC/FBP1/ADH5/PKM/ALDH9A1	0.494949592287668
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	6/1210	38/9376	1.22348847324924	SGK1/NR3C2/SCNN1A/PIK3CD/FXYD4/HSD11B2	0.531365835501418
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	13/1210	90/9376	1.11926538108356	ATF4/SIRT1/PRKACB/PIK3CD/RPTOR/ADCY9/AKT3/EHMT2/MTOR/EHMT1/TP53/SOD2/CREB3L4	0.437617772096016
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/1210	10/9376	1.5497520661157	PAPSS1/TST	0.669519806097477
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	25/1210	180/9376	1.07621671258035	SRSF3/IRAK4/CCL5/IFNAR2/POU2F2/CGAS/IRF3/SYK/HLA-B/PIK3CD/ZC3HAV1/TRADD/CASP8/TAB1/RNASEL/MAVS/DAXX/PILRA/AKT3/FADD/MTOR/TP53/ITGA5/C3/BCL2L1	0.397429975028029
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	3/1210	17/9376	1.3674282936315	GGT7/CSAD/FMO4	0.583654674979532
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	3/1210	17/9376	1.3674282936315	CA13/CA8/CA3	0.583654674979532
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	12/1210	83/9376	1.12030269839689	MBD5/UBE2D2/AEBP2/HDAC1/CBX4/SFMBT1/MGA/USP45/MBD6/AUTS2/L3MBTL4/L3MBTL3	0.42375036166796
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	27/1210	196/9376	1.06743127002867	FOS/LEF1/MAP2K6/IFNAR2/IRF3/SYK/HLA-B/NFATC3/JUN/GNG11/PIK3CD/TRADD/ITPR2/E2F3/CD200R1/CASP8/NFATC1/PIK3R6/GSK3B/AKT3/FADD/CALML4/MTOR/TP53/C3/IL6ST/PPP3CB	0.36723297426968
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	13/1210	91/9376	1.10696576151122	FOS/PTPN6/SYK/NFATC3/JUN/PIK3CD/BANK1/CD72/NFATC1/GSK3B/CARD11/AKT3/PPP3CB	0.394682767715049
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	5/1210	32/9376	1.21074380165289	BBC3/CASP8/FADD/BIRC5/BCL2L1	0.459660325179131
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	14/1210	99/9376	1.09578428917272	FOS/CDKN2C/PRKACB/JUN/PIK3CD/E2F3/ADCY9/AKT3/HBEGF/NOTCH1/MTOR/TP53/ERBB2/SP1	0.36879220687798
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	14/1210	99/9376	1.09578428917272	SLC44A1/DGKH/FOS/PLD1/WAS/CHKB/JUN/PIK3CD/PLPP2/SLC44A2/AKT3/MTOR/DGKE/SP1	0.36879220687798
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	17/1210	122/9376	1.07974529196586	SCD5/SIRT1/STRADA/CD36/PIK3CD/EEF2/LEPR/RPTOR/CPT1A/GYS1/AKT3/FBP1/MTOR/MLYCD/CAB39L/LIPE/CREB3L4	0.341266655085502
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	23/1210	168/9376	1.06084218811492	CISH/PTPN6/SOCS1/IFNAR2/IL7R/IL23A/CCND3/IL10RB/IL20RA/IL6R/PIK3CD/LEPR/IL12RB1/IL20RB/AKT3/EPOR/SOCS2/MTOR/FHL1/IL2RA/IL6ST/PIAS2/BCL2L1	0.30630243241523
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	10/1210	70/9376	1.10696576151122	UGT2B7/MGST1/MGST2/GSTK1/CBR1/GSTM4/SULT1A3/EPHX1/GSTM2/SULT1A1	0.345768892445322
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	19/1210	138/9376	1.066858306384	SOCS1/PRKACB/PIK3CD/FLOT1/PYGL/MKNK1/RPTOR/PRKAR1B/HKDC1/GSK3B/GYS1/PYGM/AKT3/FBP1/CALML4/SOCS2/MTOR/LIPE/PHKA2	0.30456470356179
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	5/1210	33/9376	1.1740545955422	BCKDHB/GOT1/DBT/ACY1/GPT2	0.385543091513449
NA	NA	hsa03272	Virion - Hepatitis viruses	7/1210	48/9376	1.13002754820937	CLDN4/SLC10A1/CLDN3/EPCAM/CLDN12/CLDN7/CHMP1B	0.347644496986546
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	10/1210	71/9376	1.09137469444768	CCL5/MET/ATP6V1E2/ATP6V1C2/TJP1/JUN/CSK/F11R/ATP6V1C1/HBEGF	0.297488758252125
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	4/1210	26/9376	1.19211697393516	PLB1/BTD/SLC19A2/SLC19A1	0.377589789130013
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	6/1210	41/9376	1.13396492642612	GRHPR/ALAS1/MAOA/AMT/SDSL/PIPOX	0.330902091894599
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	13/1210	95/9376	1.06035667681601	FOS/CCL3L1/CCL5/IL18/ATP6V1E2/IL23A/CCL20/ATP6V1C2/JUN/TNFSF11/CTSL/ATP6V1C1/CD28	0.227595343202754
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	31/1210	233/9376	1.0309509452701	COL1A2/DSP/SGCD/ITGB8/SNTB1/MYOM1/JUP/DSC2/SYNE2/NEBL/ANK3/COL27A1/DSG2/TTN/MYH11/ENO2/VCL/MYH14/COL9A2/PKP2/PDLIM2/TMOD1/SDC2/PDLIM5/FHL1/ANK2/ITGA5/DIAPH3/ITGA2/SYNE1/OBSCN	0.18415399869377
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	11/1210	80/9376	1.06545454545455	MET/IL6R/ERBB3/PIK3CD/FGFR2/GSK3B/AKT3/MTOR/PTEN/ERBB2/BCL2L1	0.226313459171417
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	9/1210	65/9376	1.07290527654164	LIPC/DGKH/PLPP2/AGPAT5/LPIN3/MOGAT1/PNPLA2/DGKE/ALDH9A1	0.227034110501175
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	9/1210	65/9376	1.07290527654164	ATF4/PLCB4/PRKACB/ITPR2/NR4A1/ADCY9/NCEH1/CREB3L4/SP1	0.227034110501175
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	21/1210	157/9376	1.03645838816655	ID1/PATJ/LEF1/TGFBR1/CDH1/YWHAH/CCND3/RASSF1/WWC1/BBC3/BMPR1B/YAP1/NKD1/GSK3B/BMPR1A/DLG2/WNT2B/CTNNA2/FZD6/BIRC5/BTRC	0.177328695308336
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	51/1210	388/9376	1.01852262077192	MT-ATP8/MT-ND2/MT-ND4L/MT-ND1/MT-ND4/MT-ATP6/MT-CO2/MT-CYB/TUBB4B/TUBA1B/ATF4/DDIT3/TUBA1C/NDUFV3/UQCRC2/SLC39A14/PLCB4/FRAT2/BACE2/PIK3CD/ITPR2/COX6B1/PPID/GAPDH/ERN1/CHRM3/ULK2/XBP1/CASP8/NDUFB5/RTN3/ATP5MC2/SLC39A10/SLC39A8/GSK3B/SLC25A6/NDUFV1/AKT3/FADD/CALML4/NDUFB9/WNT2B/MTOR/APH1B/FZD6/NDUFA3/SLC11A2/PPP3CB/NDUFS3/PSMA8/KLC4	0.143436738527938
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	4/1210	27/9376	1.14796449341904	SCD5/TECR/ELOVL6/ACOX1	0.296367413103483
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/1210	12/9376	1.29146005509642	COQ7/COQ5	0.388877305369527
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/1210	12/9376	1.29146005509642	NCAM1/SLAMF1	0.388877305369527
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	27/1210	204/9376	1.02557122022363	COL1A2/PTPN6/ARHGEF1/MET/EIF4B/CAMK2D/ERBB4/ERBB3/PRKACB/PIK3CD/ANK3/ARHGEF12/ITPR2/RRAS/CTSL/SDC2/AKT3/HBEGF/WNT2B/MTOR/TP53/FZD6/ANK2/ITGA5/DROSHA/ITGA2/ERBB2	0.142137328558136
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	12/1210	89/9376	1.04477667378587	SPP1/COL1A2/FREM2/ITGB8/CD36/LAMA5/COL9A2/HMMR/ITGA5/ITGA2/LAMC1/VWF	0.163373925847043
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	22/1210	168/9376	1.01471861471861	HSP90AA1/HSP90AB1/IFNAR2/CAMK2D/TNFSF10/TRADD/PPID/PYGL/RIPK1/FTL/CFLAR/CHMP4C/CASP8/AIFM1/SLC25A6/CHMP3/PYGM/FADD/SQSTM1/SHARPIN/CHMP1B/MLKL	0.0740990360435294
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	6/1210	44/9376	1.05664913598798	DYNLL1/PRKACB/AQP3/ADCY9/DYNC2H1/CREB3L4	0.14497926682228
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	11/1210	83/9376	1.02694414019715	CCL5/CGAS/IRF3/IL18/CCL4L2/RIPK1/DNASE2/CASP8/MAVS/FADD/MLKL	0.0949071741990978
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	16/1210	122/9376	1.01623086302669	FOS/ATF4/MAP2K6/SOCS1/PLCB4/PRKACB/PIK3CD/IGFBP3/ITPR2/ADCY9/GSK3B/AKT3/SOCS2/MTOR/MAP3K1/CREB3L4	0.0694593022073446
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	7/1210	52/9376	1.04310235219326	LIPC/ABCA1/CD36/LDLRAP1/NCEH1/MYLIP/OSBPL5	0.119970687109892
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	10/1210	76/9376	1.0195737277077	SCD5/SLC27A4/CPT2/CD36/CPT1A/ACSL5/ACADM/RXRB/ACOX1/EHHADH	0.0659496507411596
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	5/1210	37/9376	1.0471297744025	HBA1/IL18/PLCB4/IDO2/VCAM1	0.110565509313325
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	28/1210	217/9376	0.999840042655292	HSP90AA1/UGT2B7/MGST1/HSP90AB1/FOS/ATF4/PAQR8/VDR/KLF5/PTGES3/CCND3/MGST2/BCL6/PRKACB/JUN/PIK3CD/TNFSF11/GSTM4/EPHX1/ADCY9/AIP/AKT3/GSTM2/MTOR/RPS6KA1/RXRB/BIRC5/CREB3L4	-0.000917663925128498
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	20/1210	155/9376	0.999840042655292	ATF4/LEF1/CAMK2D/PLCB4/CDKN2C/PRKACB/ITPR2/E2F3/NR4A1/ADCY9/GSK3B/CCNE2/AIP/NCEH1/CCNE1/WNT2B/ASH2L/FZD6/CREB3L4/SP1	-0.000772955799186478
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	15/1210	116/9376	1.00199487033343	CLDN4/CLDN3/TXK/PECAM1/PIK3CD/AFDN/CLDN12/F11R/CTNND1/NCF4/ARHGAP5/VCL/VCAM1/CTNNA2/CLDN7	0.00832169527392424
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	17/1210	133/9376	0.990443049773193	FOS/ATF4/CLOCK/CAMK2D/PLCB4/PRKACB/GNG11/ITPR2/SLC18A2/LRTOMT/MAOA/GSK3B/GNAL/AKT3/CALML4/PPP3CB/CREB3L4	-0.0427279742970286
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	9/1210	70/9376	0.996269185360094	CD36/TRADD/LEPR/SLC2A1/CPT1A/ACSL5/AKT3/MTOR/RXRB	-0.0120599304649801
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	9/1210	70/9376	0.996269185360094	EGLN3/MET/JUN/PIK3CD/EPAS1/SLC2A1/FLCN/AKT3/PAK6	-0.0120599304649801
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	11/1210	86/9376	0.991120507399577	CAMK2D/ERBB4/ERBB3/JUN/PIK3CD/GSK3B/AKT3/HBEGF/MTOR/ERBB2/PAK6	-0.0318422064547548
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	23/1210	181/9376	0.984649102780695	VDR/CORO1A/IRAK4/HSPD1/IL18/SYK/ITGAX/IL23A/CAMK2D/IL10RB/CASP10/ARHGEF12/TRADD/TLR1/NFYB/CASP8/SPHK2/AKT3/FADD/CALML4/C3/PPP3CB/TLR6	-0.0802732451279808
Organismal Systems	Immune system	hsa04611	Platelet activation	16/1210	126/9376	0.983969565787748	COL1A2/TBXAS1/ARHGEF1/SYK/PLCB4/LCP2/PRKACB/PIK3CD/ARHGEF12/ITPR2/PIK3R6/ADCY9/SNAP23/AKT3/ITGA2/VWF	-0.0697321937051542
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	18/1210	142/9376	0.98223722500291	TEC1/FOS/TGFBR1/MAP2K6/SOCS1/IFNAR2/SYK/LCP2/JUN/PIK3CD/ITPR2/TNFSF11/NCF4/NFATC1/TAB1/AKT3/SQSTM1/PPP3CB	-0.0820982098108046
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	6/1210	47/9376	0.989203446456831	SOCS1/PIK3CD/HKDC1/SOCS2/MTOR/PKM	-0.0285621016793922
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	5/1210	39/9376	0.99343081161263	AHCY/AHCYL2/AMT/MTHFS/MTHFD2	-0.0158239162668661
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	9/1210	72/9376	0.968595041322314	IRF3/CASP10/DDX3X/TRADD/RIPK1/CASP8/MAVS/FADD/MAP3K1	-0.102968232806213
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	13/1210	105/9376	0.959370326643054	SYK/IL23A/NFATC3/JUN/PIK3CD/ARHGEF12/ITPR2/RRAS/CASP8/NFATC1/AKT3/CALML4/PPP3CB	-0.161156685011484
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	9/1210	73/9376	0.955326616098721	UGT2B7/MGST1/MGST2/GSTK1/GSTM4/MAOA/GSTM2/ADH5/FMO4	-0.147493338388234
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	6/1210	49/9376	0.948827795581042	ST3GAL3/ST6GAL1/GALNT4/RFNG/MFNG/GALNT12	-0.138240346374616
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	6/1210	49/9376	0.948827795581042	ATF4/PRKACB/JUN/SLC18A2/MAOA/CREB3L4	-0.138240346374616
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	15/1210	122/9376	0.952716434087522	PLCB4/TBC1D4/PRKACB/PIK3CD/THRB/SLC2A1/HDAC1/THRA/GSK3B/AKT3/NOTCH1/MTOR/TP53/NCOA1/RXRB	-0.202348050670813
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	12/1210	98/9376	0.948827795581042	DGKH/PIP4K2A/PLCB4/INPP5F/PIK3CD/ITPR2/PPIP5K2/MTM1/CDS1/CALML4/PTEN/DGKE	-0.196016944621368
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	12/1210	98/9376	0.948827795581042	ARPC5L/PLD1/SYK/WAS/PIK3CD/PLPP2/MYO10/LAT/SPHK2/AKT3/ACTR3C/AMPH	-0.196016944621368
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	12/1210	98/9376	0.948827795581042	ATF4/CAMK2D/PLCB4/PRKACB/ITPR2/PRKD2/ATF1/NR4A1/ADCY9/CALML4/LIPE/CREB3L4	-0.196016944621368
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	10/1210	82/9376	0.94497077202177	UGT2B7/MGST1/DPYD/MGST2/TK2/NME7/GSTM4/NME6/GMPS/GSTM2	-0.19265161217486
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	37/1210	298/9376	0.96209440346109	CXCL14/IL32/CCL3L1/TGFBR1/IL16/CD40LG/CCL5/IFNAR2/IL7R/CCL18/IL18/IL23A/CD4/CCL20/CD27/IL10RB/IL20RA/IL6R/CX3CR1/TNFSF10/CCL4L2/LEPR/EDA/CCR2/TNFSF11/TNFRSF10D/BMPR1B/CCR6/IL12RB1/CCR7/IL20RB/EPOR/BMPR1A/IL2RA/CXCL17/IL6ST/CCL28	-0.255970557382448
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	14/1210	115/9376	0.943327344592167	FOS/ATF4/CAMK2D/PLCB4/PRKACB/GNG11/PIK3CD/ITPR2/CHRM3/PIK3R6/KCNQ1/ADCY9/AKT3/CREB3L4	-0.235378708564713
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	12/1210	99/9376	0.939243676433759	MAP2K6/PTGER2/CAMK2D/PLCB4/PRKACB/HRH1/PIK3CD/ITPR2/NTRK1/ADCY9/TRPV1/CALML4	-0.233926240339719
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	26/1210	212/9376	0.950319663184157	ID1/MAGI3/MAP2K6/EVL/MET/CDH1/PLCB4/LCP2/EFNA5/EFNA1/PIK3CD/MAGI1/RGS14/AFDN/PRKD2/FGFR2/LAT/RRAS/CTNND1/VEGFB/SIPA1L3/ADCY9/KRIT1/AKT3/CALML4/LPAR3	-0.281633010340298
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	19/1210	156/9376	0.943759271031998	CLDN4/CLDN3/IFNAR2/IRF3/YWHAH/PIK3CD/TRADD/CLDN12/RIPK1/E2F3/CFLAR/CASP8/RNASEL/MAVS/GSK3B/AKT3/FADD/TP53/CLDN7	-0.272659990598754
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	9/1210	75/9376	0.929851239669421	ARG2/GAPDH/ENO2/TPI1/GOT1/PKM/SDSL/ACY1/GPT2	-0.234779106585985
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	9/1210	75/9376	0.929851239669421	ATF4/DUOX1/GPX3/PLCB4/PRKACB/ITPR2/PAX8/ADCY9/CREB3L4	-0.234779106585985
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	8/1210	67/9376	0.925225114098927	ATF4/CAMK2D/PLCB4/PRKACB/ITPR2/CALML4/RPS6KA1/PPP3CB	-0.23643691319526
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	14/1210	116/9376	0.9351952123112	DLGAP1/HOMER2/SLC38A2/GRIK4/PLD1/PLCB4/PRKACB/GNG11/HOMER1/ITPR2/SLC1A1/ADCY9/SHANK2/PPP3CB	-0.270336215041488
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	7/1210	59/9376	0.919344446000841	MGST1/GPX3/MGST2/GSTK1/GGT7/GSTM4/GSTM2	-0.239219111069466
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	7/1210	59/9376	0.919344446000841	ABHD5/PRKACB/PIK3CD/ADCY9/AKT3/PNPLA2/LIPE	-0.239219111069466
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	9/1210	76/9376	0.917616354936929	CAMK2D/PLCB4/GAST/PRKACB/ITPR2/CHRM3/KCNQ1/ADCY9/CALML4	-0.277574752230568
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	5/1210	43/9376	0.901018643090525	ABCA1/SLC27A4/CD36/PLPP2/ACAT1	-0.250409403439868
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	13/1210	110/9376	0.915762584522915	ID1/TGFBR1/ID3/SMAD9/ID4/BMPR1B/HDAC1/TFRC/BMPR1A/BAMBI/ZFYVE9/RBL1/SP1	-0.342080929682267
Organismal Systems	Endocrine system	hsa04924	Renin secretion	8/1210	69/9376	0.898406994849683	PTGER2/PLCB4/PRKACB/ITPR2/KCNMA1/CTSB/CALML4/PPP3CB	-0.326029674992838
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	10/1210	86/9376	0.901018643090525	ATF4/CAMK2D/PLCB4/PRKACB/KCNMB2/CHRM3/SLC2A1/KCNMA1/ADCY9/CREB3L4	-0.354951002688286
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	5/1210	44/9376	0.880540946656649	HSPD1/HLA-B/ICA1/CD28/PRF1	-0.305725509611969
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	17/1210	144/9376	0.914784205693297	ID1/DLX5/ID3/SMAD9/ZFHX3/PIK3CD/ID4/REST/POU5F1/FGFR2/BMPR1B/GSK3B/AKT3/BMPR1A/WNT2B/FZD6/IL6ST	-0.39666792116382
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	12/1210	103/9376	0.902768193853807	COL1A2/COL15A1/SLC15A1/SLC38A2/PRSS3/COL27A1/SLC1A1/COL28A1/SLC3A2/KCNQ1/COL9A2/COL25A1	-0.381935890710176
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	2/1210	18/9376	0.860973370064279	THAP11/ZNF143	-0.227256525805805
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	8/1210	70/9376	0.885572609208973	SGCD/CD40LG/HLA-B/SNTB1/CASP8/CD28/PRF1/CXADR	-0.369888753375282
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	14/1210	120/9376	0.904022038567493	RPS6KA5/ATF4/IRAK4/CAMK2D/MAP2K5/JUN/PIK3CD/NTRK1/GSK3B/AKT3/CALML4/RPS6KA1/TP53/MAP3K1	-0.407309094204865
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	4/1210	36/9376	0.860973370064279	GALNT4/ST6GALNAC1/GCNT3/GALNT12	-0.32169880173378
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	9/1210	79/9376	0.882770164243122	UGT2B7/MGST1/MGST2/GSTK1/CBR1/GSTM4/EPHX1/GSTM2/ADH5	-0.402767039010496
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	8/1210	71/9376	0.873099755558142	CISH/FOS/SOCS1/PIK3CD/TNFSF11/GSK3B/AKT3/SOCS2	-0.413149355727984
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	15/1210	130/9376	0.894087730451367	RXFP1/COL1A2/FOS/ATF4/TGFBR1/PLCB4/PRKACB/JUN/GNG11/PIK3CD/VEGFB/ADCY9/AKT3/ACTA2/CREB3L4	-0.468074133077705
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	3/1210	28/9376	0.830224321133412	MOCOS/CBR1/PCBD2	-0.346312984499362
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	3/1210	28/9376	0.830224321133412	ATP6V1E2/ATP6V1C2/ATP6V1C1	-0.346312984499362
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	18/1210	155/9376	0.899856038389763	TUBB4B/TUBA1B/CORO1A/TUBA1C/ATP6V1E2/HLA-B/ATP6V1C2/CD36/NCF4/STX18/CTSL/ATP6V1C1/TFRC/DYNC2H1/ITGA5/C3/ITGA2/TLR6	-0.483921860677426
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	4/1210	37/9376	0.837703819522001	RIMKLB/ASRGL1/GOT1/GPT2	-0.380743597474227
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	5/1210	46/9376	0.842256557671577	UGT2B7/CP/ALAS1/FTL/COX10	-0.412822199520767
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	3/1210	29/9376	0.801595896266743	RASSF1/WWC1/YAP1	-0.411895610615614
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	27/1210	232/9376	0.901795383300086	ITGAD/PIP4K2A/ARHGEF1/ARPC5L/ITGB8/ITGAX/PIK3CD/ARHGEF12/BAIAP2/FGFR2/RRAS/CHRM3/MYH11/VCL/FGD3/MYH14/SPATA13/ARHGEF6/NCKAP1/CYFIP2/WASL/AKT3/ACTR3C/ITGA5/DIAPH3/ITGA2/PAK6	-0.583017276302569
Human Diseases	Immune disease	hsa05330	Allograft rejection	4/1210	39/9376	0.794744649290104	CD40LG/HLA-B/CD28/PRF1	-0.494420816002796
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	7/1210	66/9376	0.821838216879539	UGT2B7/LRTOMT/SULT1E1/HSD17B8/SULT2B1/HSD11B2/HSD17B11	-0.559094620395462
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/1210	21/9376	0.737977174340811	DSE/CSGALNACT1	-0.462701079560174
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	16/1210	144/9376	0.860973370064279	FGF14/PLCB4/PIK3CD/ITPR2/GTF2B/ERN1/ULK2/XBP1/OMA1/SLC25A6/AKT3/MTOR/TBPL1/PSMA8/SP1/BEAN1	-0.647150035174594
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	3/1210	31/9376	0.749880031991469	IMMP2L/UBL4A/IMMP1L	-0.536924466252212
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	7/1210	68/9376	0.797666504618376	LEF1/JUP/PIK3CD/DUSP6/AKT3/PIM2/MTOR	-0.644566438523739
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	3/1210	32/9376	0.726446280991736	HKDC1/GANC/UGP2	-0.596657127977617
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	6/1210	60/9376	0.774876033057851	HSPB1/PIK3CD/SPHK2/AKT3/PPP3CB/MAPKAPK3	-0.673373860684054
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	5/1210	51/9376	0.759682385350835	PLB1/PLD1/PLPP2/PLD3/GDPD1	-0.662399365824536
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	8/1210	78/9376	0.794744649290104	FOS/IRAK4/IRF3/IL23A/JUN/CALML4/ITGA5/C3	-0.700681503756117
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	8/1210	79/9376	0.78468459043833	ATP6V1E2/ATP6V1C2/STX3/SLC18A2/SLC1A1/CLTA/ATP6V1C1/UNC13B	-0.739760056836875
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	16/1210	149/9376	0.832081646236619	DGKH/PLD1/SYK/PLCB4/PIK3CD/PLPP2/RRAS/AGPAT5/CYTH4/PIK3R6/ADCY9/SPHK2/AKT3/MTOR/DGKE/LPAR3	-0.795306766253256
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	16/1210	149/9376	0.832081646236619	MT-ND2/MT-ND4L/GABRP/MT-ND1/MT-ND4/NDUFV3/PLCB4/PRKACB/GNG11/ITPR2/NDUFB5/ADCY9/NDUFV1/NDUFB9/NDUFA3/NDUFS3	-0.795306766253256
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	9/1210	89/9376	0.7835825053394	TUBB4B/TUBA1B/TUBA1C/PLCB4/TJP1/MAP2K5/PRKACB/ITPR2/ADCY9	-0.78962934794508
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	21/1210	193/9376	0.843129362394553	CXCL14/CCL3L1/CCL5/CCL18/WAS/FGR/CCL20/PLCB4/CX3CR1/PRKACB/GNG11/CCL4L2/PIK3CD/CCR2/PIK3R6/CCR6/ADCY9/GSK3B/CCR7/AKT3/CCL28	-0.847620905831313
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	5/1210	53/9376	0.731015125526275	VDR/PLCB4/PRKACB/CLTA/ADCY9	-0.755895200355059
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	13/1210	125/9376	0.805871074380165	S1PR4/PLD1/PLCB4/SGPP2/PIK3CD/TRADD/ORMDL3/SPHK2/AKT3/ACER2/TP53/PTEN/CERS4	-0.841055301315577
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	14/1210	134/9376	0.809571974836561	ARHGEF1/PLCB4/ADM/PRKACB/ARHGEF12/ITPR2/KCNMB2/MYH11/MYL6B/MYH14/KCNMA1/ADCY9/CALML4/ACTA2	-0.854621700565472
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	6/1210	63/9376	0.737977174340811	PLB1/TBXAS1/PTGIS/PTGES3/PTGR1/CBR1	-0.803226881606317
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	7/1210	73/9376	0.743031812521227	CD4/MDFIC/APOBEC3H/PSIP1/APOBEC3D/XPO1/BICD1	-0.848404408194662
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	10/1210	101/9376	0.767203993126585	LEF1/CAMK2D/PLCB4/PRKACB/ADCY9/GSK3B/CALML4/WNT2B/FZD6/CREB3L4	-0.905425850951881
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	10/1210	101/9376	0.767203993126585	COL1A2/TGFBR1/PLCB4/JUN/PIK3CD/VEGFB/NFATC1/VCAM1/AKT3/EGR1	-0.905425850951881
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	16/1210	154/9376	0.805066008371794	FOS/CAMK2D/PLCB4/NFATC3/MAP2K5/PRKACB/JUN/CACNA2D4/EEF2/ITPR2/MYL6B/NFATC1/PIK3R6/ADCY9/CALML4/PPP3CB	-0.938877676154047
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/1210	26/9376	0.596058486967578	PLB1/ACOX1	-0.793913143657215
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	18/1210	173/9376	0.806229398557302	DNAJB1/IRAK4/CCL5/IFNAR2/IRF3/IL18/CCND3/PRSS3/TNFSF10/PIK3CD/TRADD/CASP8/XPO1/RNASEL/MAVS/SLC25A6/AKT3/FADD	-0.990193026327892
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	6/1210	66/9376	0.704432757325319	IL18/IL23A/JUN/MAF/NFATC1/IL12RB1	-0.927528072801131
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	10/1210	103/9376	0.752306828211506	COL1A2/HSPB1/ARG2/PLCB4/PRKACB/PIK3CD/LAMA5/VCL/GNAL/LAMC1	-0.972962613155896
NA	NA	hsa04382	Cornified envelope formation	23/1210	217/9376	0.821297177895418	KRT19/KRT8/CLDN4/KRT18/DSP/CLDN3/KRT23/KRT7/S100A11/TJP1/ABHD5/PCSK6/SLC27A4/JUP/CLDN12/DSG2/LAMA5/S100A13/KDSR/PKP2/UGCG/DST/CLDN7	-1.02520539749697
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	9/1210	94/9376	0.741902584842624	HSP90AA1/HSP90AB1/FOS/CCL20/JUN/TRADD/CASP8/GSK3B/FADD	-0.968055898308386
NA	NA	hsa04519	Cadherin signaling	45/1210	404/9376	0.863104492267408	KRT19/KRT8/GABRP/KRT18/DSP/MYO1E/LEF1/EVL/ARPC5L/MET/KRT23/MYO1F/CDH1/YWHAH/PCDH7/KRT7/TJP1/WWC1/TAOK3/LIMA1/JUP/DSC2/AFDN/DSG2/TMC4/CELSR1/RRAS/CTNND1/VCL/YAP1/TMC5/ERBIN/GSK3B/NCKAP1/PKP2/TMC8/CYFIP2/WNT2B/APH1B/MYO1D/CTNNA2/ACTR3C/FZD6/MYO1C/ERBB2	-1.08270185915944
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	10/1210	104/9376	0.745073108709472	PLB1/DGKH/PLD1/CHKB/PLPP2/AGPAT5/PLD3/LPIN3/CDS1/DGKE	-1.00628093293601
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	4/1210	48/9376	0.645730027548209	PLCB4/PIK3CD/HKDC1/AKT3	-0.947183947298089
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	21/1210	203/9376	0.801595896266743	SPP1/COL1A2/MET/ITGB8/CCND3/JUN/PIK3CD/LAMA5/ARHGAP5/VCL/VEGFB/COL9A2/GSK3B/AKT3/PTEN/ITGA5/ITGA2/LAMC1/ERBB2/PAK6/VWF	-1.10006059575284
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	25/1210	238/9376	0.813945412875894	ZAP70/MET/PLD1/RALGAPA2/RASSF1/EFNA5/PRKACB/EFNA1/GNG11/FLT3LG/PIK3CD/AFDN/FGFR2/LAT/RRAS/VEGFB/NTRK1/AKT3/CALML4/RASGRF2/RGL2/RGL1/RASAL3/PAK6/BCL2L1	-1.11912067505268
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	7/1210	78/9376	0.695401568128841	FOS/PTPN6/IRAK4/JUN/NCF4/TAB1/C3	-1.03980961542333
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	9/1210	97/9376	0.718957144074295	FOS/RPS6KA5/CAMK2D/PLCB4/PRKACB/GNG11/ADCY9/PER3/CALML4	-1.07098025822299
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	6/1210	69/9376	0.673805246137262	MAP2K6/SYK/LCP2/PIK3CD/LAT/AKT3	-1.04681586521515
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	8/1210	88/9376	0.704432757325319	CD59/ITGAX/C3AR1/F8/SERPINA5/KLKB1/C3/VWF	-1.07228484597859
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/1210	17/9376	0.455809431210501	AMACR	-0.864439062148833
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	10/1210	108/9376	0.717477808386899	RANBP17/UPF2/NUP210L/SNUPN/PYM1/DDX39B/XPO1/GLE1/NUP62/NUP37	-1.13669792524268
Organismal Systems	Digestive system	hsa04976	Bile secretion	8/1210	90/9376	0.688778696051423	UGT2B7/SLC10A1/PRKACB/SLC2A1/EPHX1/ADCY9/NCEH1/SLC4A5	-1.14195730919912
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	26/1210	254/9376	0.79318019131906	MET/CAMK2D/PLCB4/ERBB4/NFATC3/ERBB3/PRKACB/ASPH/HRH1/ORAI2/ITPR2/FGFR2/CHRM3/TPCN1/VEGFB/NTRK1/NFATC1/ADCY9/ORAI3/SLC25A6/SPHK2/GNAL/CALML4/PPP3CB/ERBB2/PHKA2	-1.2862861456834
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	16/1210	166/9376	0.746868465597929	ATF4/MEF2A/PLCB4/NFATC3/ITPR2/KCNMB2/NFATC1/PIK3R6/KCNMA1/ADCY9/SLC25A6/AKT3/CALML4/PPP3CB/MEF2B/CREB3L4	-1.26661351050867
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/1210	31/9376	0.499920021327646	RBKS/FBP1	-1.07350555723289
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/1210	31/9376	0.499920021327646	UGT2B7/ALDH9A1	-1.07350555723289
NA	NA	hsa04981	Folate transport and metabolism	2/1210	31/9376	0.499920021327646	SLC19A1/MTHFS	-1.07350555723289
Organismal Systems	Digestive system	hsa04970	Salivary secretion	8/1210	93/9376	0.666560028436861	PRH1/PLCB4/PRKACB/ITPR2/CHRM3/KCNMA1/ADCY9/CALML4	-1.24390895645722
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/1210	19/9376	0.40782949108308	HEXA	-0.994555208871739
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	4/1210	54/9376	0.573982246709519	CD40LG/HLA-B/CD28/PRF1	-1.208491677378
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	5/1210	65/9376	0.596058486967578	SPP1/PLCB4/PIK3CD/ITPR2/AKT3	-1.25791309567882
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	9/1210	105/9376	0.66417945690673	SGCD/ITGB8/SNTB1/PRKACB/CACNA2D4/TTN/ADCY9/ITGA5/ITGA2	-1.33202462663696
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	2/1210	34/9376	0.455809431210501	POLR2A/POLR1E	-1.22361325662969
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	17/1210	184/9376	0.715918074020841	SLIT2/MET/RGS3/CAMK2D/EFNA5/NFATC3/EFNA1/EFNB2/PIK3CD/ARHGEF12/SRGAP3/RRAS/BMPR1B/LRIG2/GSK3B/PPP3CB/PAK6	-1.49803218046674
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	8/1210	102/9376	0.607745908280668	PLCB4/PRSS3/ITPR2/CHRM3/KCNQ1/KCNMA1/ADCY9/SLC26A3	-1.53323123528268
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	8/1210	103/9376	0.601845462569205	UPF2/PYM1/FUS/PCF11/DDX39B/CPSF3/CSTF1/GLE1	-1.56398933560162
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	3/1210	50/9376	0.464925619834711	CD40LG/CD28/CCL28	-1.46024285277021
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/1210	26/9376	0.298029243483789	HES1	-1.37966461005083
Organismal Systems	Sensory system	hsa04742	Taste transduction	6/1210	86/9376	0.540611185854315	PLCB4/SCNN1A/PRKACB/CHRM3/PKD1L3/TAS2R30	-1.64738618762241
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	6/1210	87/9376	0.534397264177829	MT-CO2/MT-CYB/UQCRC2/ASPH/CACNA2D4/COX6B1	-1.67943926981171
Genetic Information Processing	Transcription	hsa03040	Spliceosome	22/1210	243/9376	0.701533857089413	HSPA1B/HSPA1A/HSPA6/SRSF3/PRPF6/HSPA1L/RBM22/FUS/DDX39B/HSPA8/SYF2/SNW1/TRA2B/PRPF40B/CDC40/PRPF19/PHF5A/PRPF38B/XAB2/SNRPD1/RBMX2/DDX23	-1.81453402720347
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	7/1210	99/9376	0.547892144586359	SGCD/ITGB8/SNTB1/CACNA2D4/TTN/ITGA5/ITGA2	-1.74072235838397
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4/1210	68/9376	0.455809431210501	UGT2B7/RDH10/CYP26A1/ADH5	-1.73360805209869
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/1210	29/9376	0.267198632088914	CALML4	-1.52132774078855
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	12/1210	154/9376	0.603799506278845	RPS6KA5/ATF4/CAMK2D/PLCB4/PRKACB/CACNA2D4/PIK3R6/KCNQ1/ADCY9/AKT3/CALML4/CREB3L4	-1.90825517770898
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/1210	30/9376	0.258292011019284	SUCLG2	-1.56622564754753
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/1210	30/9376	0.258292011019284	PLB1	-1.56622564754753
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/1210	30/9376	0.258292011019284	SLC19A1	-1.56622564754753
Human Diseases	Immune disease	hsa05310	Asthma	1/1210	32/9376	0.242148760330578	CD40LG	-1.65297458113436
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	6/1210	99/9376	0.46962183821688	DEFB1/KRT19/KRT18/KRT23/C3AR1/C3	-2.04208158199282
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	5/1210	89/9376	0.435323614077444	GABRP/SLC38A2/PRKACB/GNG11/ADCY9	-2.06030037966791
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	2/1210	52/9376	0.298029243483789	PRKACB/ADCY9	-1.95385888947998
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	7/1210	115/9376	0.471663672296083	PLCB4/PRKACB/GNG11/ITPR2/SLC18A2/MAOA/DUSP1	-2.19434084406043
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/1210	41/9376	0.188994154404354	GABRP	-2.00323725026893
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	17/1210	226/9376	0.582871352300154	FOS/PLD1/PTGER2/CAMK2D/PRKACB/JUN/PIK3CD/AFDN/GLI1/RRAS/NFATC1/ADCY9/AKT3/CALML4/ACOX1/LIPE/CREB3L4	-2.44335924491639
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/1210	60/9376	0.258292011019284	PLCB4/ITPR2	-2.21854109459832
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	1/1210	46/9376	0.168451311534315	PSMA8	-2.17620303902269
Human Diseases	Substance dependence	hsa05032	Morphine addiction	4/1210	91/9376	0.340604849695759	GABRP/PRKACB/GNG11/ADCY9	-2.43303931335701
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	13/1210	195/9376	0.516584022038567	SYK/PLCB4/PIK3CD/NCF4/HDAC10/HDAC1/SLC25A6/AKT3/HDAC8/MTOR/C3/HDAC7/VWF	-2.62583207040481
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	25/1210	323/9376	0.599749251592764	RPS6KA5/ATM/SPRY2/SOCS1/MET/RASSF1/EFNA5/SIRT1/ERBB3/EFNA1/PIK3CD/BRCA1/E2F3/DDIT4/RPTOR/HDAC1/CCNE2/NOTCH1/CCNE1/MTOR/TP53/PTEN/ITGA5/ERBB2/CDC25C	-2.8178040513058
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	11/1210	183/9376	0.465772478887233	IMP3/NVL/RPP38/REXO5/XPO1/WDR3/UTP14A/REXO1/RPP25L/GNL3L/DROSHA	-2.80929151594737
NA	NA	hsa04081	Hormone signaling	14/1210	219/9376	0.495354541680818	SMAD9/PLCB4/GAST/PRKACB/GNG11/PIK3CD/SLC40A1/LEPR/THRB/BMPR1B/THRA/ADCY9/EPOR/BMPR1A	-2.90874369526921
Human Diseases	Substance dependence	hsa05034	Alcoholism	11/1210	191/9376	0.446263683960019	ATF4/PRKACB/GNG11/SLC18A2/MAOA/HDAC10/HDAC1/HDAC8/CALML4/HDAC7/CREB3L4	-2.97614266581964
NA	NA	hsa04082	Neuroactive ligand signaling	11/1210	199/9376	0.428323435358611	GABRP/GRIK4/PLCB4/PRKACB/HRH1/GNG11/SLC18A2/SLC1A1/CHRM3/ADCY9/GNAL	-3.13761893330546
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	23/1210	370/9376	0.481679696225151	RXFP1/GAL/GABRP/GRIK4/S1PR4/PTGER2/PRSS3/ADM/HRH1/PYY/PTGDR/LEPR/THRB/CHRM3/C3AR1/THRA/CNR2/CHRNA5/TRPV1/NMUR1/C3/LPAR3/PTH2R	-3.91567598684524
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	4/1210	143/9376	0.216748540715483	CD40LG/CD28/C3/SNRPD1	-3.63305062163936
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	6/1210	449/9376	0.103546908649156	OR2Z1/CAMK2D/NCALD/PRKACB/GNAL/CALML4	-7.49327390535702