ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0008175 tRNA methyltransferase activity 17/2774 34/18639 0.5 3.35958904109589 1.50732021113808e-06 0.00192183326920105 GO:0051087 protein-folding chaperone binding 40/2774 134/18639 0.298507462686567 2.00572480065426 7.24566426838069e-06 0.00461911097109269 GO:0008569 minus-end-directed microtubule motor activity 10/2774 17/18639 0.588235294117647 3.95245769540693 3.72460271916713e-05 0.0151438875731352 GO:0008173 RNA methyltransferase activity 23/2774 67/18639 0.343283582089552 2.3065835207524 5.81696499166249e-05 0.0151438875731352 GO:0031072 heat shock protein binding 37/2774 131/18639 0.282442748091603 1.89778312245111 5.93877944044517e-05 0.0151438875731352 GO:0004536 DNA nuclease activity 22/2774 64/18639 0.34375 2.30971746575342 8.17386550542705e-05 0.0173694641990325 GO:0030983 mismatched DNA binding 8/2774 14/18639 0.571428571428571 3.83953033268102 0.000307896920445451 0.0397104599333148 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 42/2774 167/18639 0.251497005988024 1.68985317037159 0.000337575987328764 0.0397104599333148 GO:0051959 dynein light intermediate chain binding 12/2774 28/18639 0.428571428571429 2.87964774951076 0.000340349163836611 0.0397104599333148 GO:0035091 phosphatidylinositol binding 64/2774 284/18639 0.225352112676056 1.51418097626857 0.000355728568403423 0.0397104599333148 GO:0019205 nucleobase-containing compound kinase activity 16/2774 44/18639 0.363636363636364 2.44333748443337 0.000360908994209136 0.0397104599333148 GO:0004527 exonuclease activity 25/2774 84/18639 0.297619047619048 1.9997553816047 0.000373745505254728 0.0397104599333148 GO:0140097 catalytic activity, acting on DNA 73/2774 336/18639 0.217261904761905 1.45982142857143 0.000452601053980614 0.0416119403125217 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 11/2774 25/18639 0.44 2.95643835616438 0.000456915423039454 0.0416119403125217 GO:0051082 unfolded protein binding 32/2774 121/18639 0.264462809917355 1.77697271595155 0.000652999414707099 0.0479902789067248 GO:0004518 nuclease activity 49/2774 209/18639 0.23444976076555 1.57530969391099 0.000660434055522823 0.0479902789067248 GO:0008168 methyltransferase activity 48/2774 204/18639 0.235294117647059 1.58098307816277 0.000684954348380517 0.0479902789067248 GO:0004529 DNA exonuclease activity 11/2774 26/18639 0.423076923076923 2.8427291886196 0.000686132322437622 0.0479902789067248 GO:0030544 Hsp70 protein binding 17/2774 51/18639 0.333333333333333 2.23972602739726 0.000766646406025594 0.0479902789067248 GO:0050145 nucleoside monophosphate kinase activity 9/2774 19/18639 0.473684210526316 3.18276856524874 0.000788987831167999 0.0479902789067248 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 19/2774 60/18639 0.316666666666667 2.1277397260274 0.000790428123169585 0.0479902789067248 GO:0003684 damaged DNA binding 22/2774 74/18639 0.297297297297297 1.99759348389485 0.000832128243975216 0.0482256141394727 GO:0016776 phosphotransferase activity, phosphate group as acceptor 14/2774 39/18639 0.358974358974359 2.41201264488936 0.000963761856676311 0.0534259290114042 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 7/2774 13/18639 0.538461538461538 3.61801896733404 0.00120260650643685 0.0568321681452176 GO:0140666 annealing activity 7/2774 13/18639 0.538461538461538 3.61801896733404 0.00120260650643685 0.0568321681452176 GO:0016741 transferase activity, transferring one-carbon groups 49/2774 215/18639 0.227906976744186 1.53134756291813 0.0012725372956886 0.0568321681452176 GO:0140662 ATP-dependent protein folding chaperone 14/2774 40/18639 0.35 2.35171232876712 0.00128198327168559 0.0568321681452176 GO:0016427 tRNA (cytidine) methyltransferase activity 6/2774 10/18639 0.6 4.03150684931507 0.00132092145895887 0.0568321681452176 GO:0070513 death domain binding 6/2774 10/18639 0.6 4.03150684931507 0.00132092145895887 0.0568321681452176 GO:0045505 dynein intermediate chain binding 13/2774 36/18639 0.361111111111111 2.4263698630137 0.00136322914522408 0.0568321681452176 GO:0003697 single-stranded DNA binding 31/2774 121/18639 0.256198347107438 1.72144231857806 0.00138180173529549 0.0568321681452176 GO:0003735 structural constituent of ribosome 41/2774 175/18639 0.234285714285714 1.57420743639922 0.00175980006243619 0.0701170337376921 GO:0140416 transcription regulator inhibitor activity 12/2774 33/18639 0.363636363636364 2.44333748443337 0.00193089568859524 0.0746027879684524 GO:0004520 DNA endonuclease activity 14/2774 42/18639 0.333333333333333 2.23972602739726 0.00218410104868881 0.0801667897818325 GO:0003714 transcription corepressor activity 46/2774 204/18639 0.225490196078431 1.51510878323932 0.00220065697440325 0.0801667897818325 GO:0098641 cadherin binding involved in cell-cell adhesion 8/2774 18/18639 0.444444444444444 2.98630136986301 0.00257059742693426 0.0910419922039215 GO:0098631 cell adhesion mediator activity 21/2774 76/18639 0.276315789473684 1.8566149963951 0.00294248930966981 0.10139659107646 GO:0005085 guanyl-nucleotide exchange factor activity 50/2774 230/18639 0.217391304347826 1.460690887433 0.00325040935828121 0.109059787679172 GO:0030695 GTPase regulator activity 95/2774 489/18639 0.194274028629857 1.30536179510883 0.0033479327917734 0.109451648961823 GO:0060589 nucleoside-triphosphatase regulator activity 95/2774 490/18639 0.193877551020408 1.30269779144535 0.00355950325554539 0.113459166270509 GO:0140101 catalytic activity, acting on a tRNA 33/2774 139/18639 0.237410071942446 1.59520055188726 0.0037537451812517 0.116732319660876 GO:0003995 acyl-CoA dehydrogenase activity 6/2774 12/18639 0.5 3.35958904109589 0.00444443690996981 0.1317827223305 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 6/2774 12/18639 0.5 3.35958904109589 0.00444443690996981 0.1317827223305 GO:0002039 p53 binding 19/2774 69/18639 0.27536231884058 1.85020845741513 0.00473780844481051 0.13728876743485 GO:0017080 sodium channel regulator activity 13/2774 41/18639 0.317073170731707 2.13047109923154 0.00505574257400697 0.142705542750758 GO:0098632 cell-cell adhesion mediator activity 16/2774 55/18639 0.290909090909091 1.9546699875467 0.00514859213061557 0.142705542750758 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 17/2774 60/18639 0.283333333333333 1.90376712328767 0.00536850494289976 0.14415482243625 GO:0160215 deacylase activity 18/2774 65/18639 0.276923076923077 1.86069546891465 0.00552059458912993 0.14415482243625 GO:0140612 DNA damage sensor activity 9/2774 24/18639 0.375 2.51969178082192 0.00554006768578529 0.14415482243625 GO:0044183 protein folding chaperone 20/2774 75/18639 0.266666666666667 1.79178082191781 0.00565852440924147 0.144292372435657 GO:0140297 DNA-binding transcription factor binding 93/2774 488/18639 0.190573770491803 1.28049910172917 0.00637008282486367 0.159252070621592 GO:0000146 microfilament motor activity 12/2774 38/18639 0.315789473684211 2.12184571016583 0.00720539635220249 0.173908838261806 GO:0030159 signaling receptor complex adaptor activity 15/2774 52/18639 0.288461538461538 1.93822444678609 0.00722915170813781 0.173908838261806 GO:0008373 sialyltransferase activity 8/2774 21/18639 0.380952380952381 2.55968688845401 0.00790124905003465 0.186557269236929 GO:0051219 phosphoprotein binding 23/2774 93/18639 0.247311827956989 1.66173221387539 0.00846482770658645 0.196230096834504 GO:0016783 sulfurtransferase activity 5/2774 10/18639 0.5 3.35958904109589 0.00952662096947535 0.215457904773206 GO:0003774 cytoskeletal motor activity 34/2774 153/18639 0.222222222222222 1.49315068493151 0.00963223574280217 0.215457904773206 GO:0050681 nuclear androgen receptor binding 9/2774 26/18639 0.346153846153846 2.32586933614331 0.0100240153423505 0.219007926094952 GO:0019887 protein kinase regulator activity 52/2774 255/18639 0.203921568627451 1.37018533440774 0.0102113944074427 0.219007926094952 GO:0141003 histone H2AX kinase activity 69/2774 354/18639 0.194915254237288 1.30967030415603 0.0103062553456448 0.219007926094952 GO:0031625 ubiquitin protein ligase binding 60/2774 302/18639 0.198675496688742 1.33493604281956 0.0107655962003565 0.21904810184996 GO:0004407 histone deacetylase activity 8/2774 22/18639 0.363636363636364 2.44333748443337 0.0108235532678804 0.21904810184996 GO:0033558 protein lysine deacetylase activity 8/2774 22/18639 0.363636363636364 2.44333748443337 0.0108235532678804 0.21904810184996 GO:0008409 5'-3' exonuclease activity 7/2774 18/18639 0.388888888888889 2.61301369863014 0.0112903404456978 0.224924751066636 GO:0070273 phosphatidylinositol-4-phosphate binding 10/2774 31/18639 0.32258064516129 2.16747680070703 0.0116652095747497 0.228817572427782 GO:0000049 tRNA binding 20/2774 80/18639 0.25 1.67979452054795 0.0119496039506332 0.230844621773595 GO:0140996 histone H3 kinase activity 69/2774 357/18639 0.19327731092437 1.29866467134799 0.0124314415134235 0.235001165468723 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 16/2774 60/18639 0.266666666666667 1.79178082191781 0.0125333954916652 0.235001165468723 GO:0003712 transcription coregulator activity 92/2774 495/18639 0.185858585858586 1.24881693648817 0.0129118014655099 0.238587635775726 GO:0005543 phospholipid binding 92/2774 497/18639 0.185110663983903 1.24379151622061 0.0143048875713429 0.256289253876825 GO:0003887 DNA-directed DNA polymerase activity 8/2774 23/18639 0.347826086956522 2.33710541989279 0.0144728049248089 0.256289253876825 GO:0140103 catalytic activity, acting on a glycoprotein 8/2774 23/18639 0.347826086956522 2.33710541989279 0.0144728049248089 0.256289253876825 GO:0035173 histone kinase activity 69/2774 360/18639 0.191666666666667 1.28784246575342 0.0149092190830721 0.260400744259135 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 67/2774 349/18639 0.191977077363897 1.28992817050673 0.0156950906400254 0.268393544028848 GO:0019213 deacetylase activity 11/2774 37/18639 0.297297297297297 1.99759348389485 0.0159172751998504 0.268393544028848 GO:0016757 glycosyltransferase activity 53/2774 267/18639 0.198501872659176 1.33376943204556 0.0159983602715235 0.268393544028848 GO:0051213 dioxygenase activity 22/2774 93/18639 0.236559139784946 1.58948298718515 0.0165662577991181 0.274311411608774 GO:0140098 catalytic activity, acting on RNA 73/2774 387/18639 0.188630490956072 1.26744186046512 0.0179066598376902 0.292705016577628 GO:0044389 ubiquitin-like protein ligase binding 62/2774 322/18639 0.192546583850932 1.29375478601208 0.0183872480846862 0.295723263572417 GO:0045296 cadherin binding 64/2774 334/18639 0.191616766467066 1.28750717742597 0.0185551851653282 0.295723263572417 GO:0016829 lyase activity 41/2774 200/18639 0.205 1.37743150684932 0.019018621547946 0.299265870600405 GO:0004519 endonuclease activity 28/2774 127/18639 0.220472440944882 1.48139359292417 0.0194240270226853 0.299265870600405 GO:1990841 promoter-specific chromatin binding 17/2774 68/18639 0.25 1.67979452054795 0.0194816213802617 0.299265870600405 GO:0035402 histone H3T11 kinase activity 49/2774 247/18639 0.198380566801619 1.33295435638622 0.0201054385520429 0.299922350742682 GO:0008408 3'-5' exonuclease activity 15/2774 58/18639 0.258620689655172 1.73771846953236 0.0202183763727397 0.299922350742682 GO:0008276 protein methyltransferase activity 22/2774 95/18639 0.231578947368421 1.55602018745494 0.020986097129106 0.299922350742682 GO:0031418 L-ascorbic acid binding 7/2774 20/18639 0.35 2.35171232876712 0.0210099010022938 0.299922350742682 GO:0140664 ATP-dependent DNA damage sensor activity 7/2774 20/18639 0.35 2.35171232876712 0.0210099010022938 0.299922350742682 GO:0015631 tubulin binding 72/2774 385/18639 0.187012987012987 1.25657356342288 0.0223002536808446 0.299922350742682 GO:1901981 phosphatidylinositol phosphate binding 38/2774 185/18639 0.205405405405405 1.38015549796372 0.0225825619812683 0.299922350742682 GO:0016423 tRNA (guanine) methyltransferase activity 5/2774 12/18639 0.416666666666667 2.79965753424658 0.0231367677957796 0.299922350742682 GO:0141221 histone deacetylase activity, hydrolytic mechanism 5/2774 12/18639 0.416666666666667 2.79965753424658 0.0231367677957796 0.299922350742682 GO:0051287 NAD binding 14/2774 54/18639 0.259259259259259 1.74200913242009 0.0238624452858194 0.299922350742682 GO:0050660 flavin adenine dinucleotide binding 20/2774 86/18639 0.232558139534884 1.56259955399809 0.0257339279723651 0.299922350742682 GO:0004676 3-phosphoinositide-dependent protein kinase activity 48/2774 245/18639 0.195918367346939 1.31641039977635 0.0261108870058335 0.299922350742682 GO:0004711 ribosomal protein S6 kinase activity 48/2774 245/18639 0.195918367346939 1.31641039977635 0.0261108870058335 0.299922350742682 GO:0035175 histone H3S10 kinase activity 48/2774 245/18639 0.195918367346939 1.31641039977635 0.0261108870058335 0.299922350742682 GO:0035979 histone H2AXS139 kinase activity 48/2774 245/18639 0.195918367346939 1.31641039977635 0.0261108870058335 0.299922350742682 GO:0044022 histone H3S28 kinase activity 48/2774 245/18639 0.195918367346939 1.31641039977635 0.0261108870058335 0.299922350742682 GO:0044023 histone H4S1 kinase activity 48/2774 245/18639 0.195918367346939 1.31641039977635 0.0261108870058335 0.299922350742682 GO:0044024 histone H2AS1 kinase activity 48/2774 245/18639 0.195918367346939 1.31641039977635 0.0261108870058335 0.299922350742682 GO:0044025 histone H2BS14 kinase activity 48/2774 245/18639 0.195918367346939 1.31641039977635 0.0261108870058335 0.299922350742682 GO:0072354 histone H3T3 kinase activity 48/2774 245/18639 0.195918367346939 1.31641039977635 0.0261108870058335 0.299922350742682 GO:0072371 histone H2AS121 kinase activity 48/2774 245/18639 0.195918367346939 1.31641039977635 0.0261108870058335 0.299922350742682 GO:0072518 Rho-dependent protein serine/threonine kinase activity 48/2774 245/18639 0.195918367346939 1.31641039977635 0.0261108870058335 0.299922350742682 GO:0140823 histone H2BS36 kinase activity 48/2774 245/18639 0.195918367346939 1.31641039977635 0.0261108870058335 0.299922350742682 GO:0140855 histone H3S57 kinase activity 48/2774 245/18639 0.195918367346939 1.31641039977635 0.0261108870058335 0.299922350742682 GO:0140995 histone H2A kinase activity 48/2774 245/18639 0.195918367346939 1.31641039977635 0.0261108870058335 0.299922350742682 GO:0140997 histone H4 kinase activity 48/2774 245/18639 0.195918367346939 1.31641039977635 0.0261108870058335 0.299922350742682 GO:0140998 histone H2B kinase activity 48/2774 245/18639 0.195918367346939 1.31641039977635 0.0261108870058335 0.299922350742682 GO:1990244 histone H2AT120 kinase activity 48/2774 245/18639 0.195918367346939 1.31641039977635 0.0261108870058335 0.299922350742682 GO:0019843 rRNA binding 16/2774 65/18639 0.246153846153846 1.65395152792413 0.0264000092349913 0.300535819416195 GO:0004677 DNA-dependent protein kinase activity 48/2774 246/18639 0.195121951219512 1.31105913798864 0.0278953384475341 0.311987337900053 GO:0140857 histone H3T45 kinase activity 48/2774 246/18639 0.195121951219512 1.31105913798864 0.0278953384475341 0.311987337900053 GO:0008017 microtubule binding 53/2774 276/18639 0.192028985507246 1.29027695056581 0.0287637477615628 0.318902420834717 GO:0008170 N-methyltransferase activity 22/2774 98/18639 0.224489795918367 1.5083869164104 0.0292625342916824 0.320741660297004 GO:0016922 nuclear receptor binding 29/2774 137/18639 0.211678832116788 1.42230776922308 0.0294327641213721 0.320741660297004 GO:0035403 histone H3T6 kinase activity 48/2774 247/18639 0.194331983805668 1.30575120625589 0.0297743092765976 0.321713934980185 GO:0005096 GTPase activator activity 52/2774 271/18639 0.191881918819188 1.28928878329879 0.0304516256996608 0.326267418210651 GO:0004550 nucleoside diphosphate kinase activity 6/2774 17/18639 0.352941176470588 2.37147461724416 0.0307126999659359 0.326322437138069 GO:0004679 AMP-activated protein kinase activity 48/2774 248/18639 0.193548387096774 1.30048608042422 0.0317508972988358 0.329915219531766 GO:0005164 tumor necrosis factor receptor binding 9/2774 31/18639 0.290322580645161 1.95072912063632 0.0324575515635901 0.329915219531766 GO:0016830 carbon-carbon lyase activity 13/2774 51/18639 0.254901960784314 1.71273166800967 0.0328594758906087 0.329915219531766 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 5/2774 13/18639 0.384615384615385 2.58429926238145 0.0330827797403752 0.329915219531766 GO:0035325 Toll-like receptor binding 5/2774 13/18639 0.384615384615385 2.58429926238145 0.0330827797403752 0.329915219531766 GO:0046974 histone H3K9 methyltransferase activity 5/2774 13/18639 0.384615384615385 2.58429926238145 0.0330827797403752 0.329915219531766 GO:0140410 monoatomic cation:bicarbonate symporter activity 5/2774 13/18639 0.384615384615385 2.58429926238145 0.0330827797403752 0.329915219531766 GO:0005484 SNAP receptor activity 10/2774 36/18639 0.277777777777778 1.86643835616438 0.0333483589558973 0.329915219531766 GO:0042169 SH2 domain binding 11/2774 41/18639 0.268292682926829 1.80270631473438 0.0335957810252007 0.329915219531766 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 47/2774 243/18639 0.193415637860082 1.29959411466261 0.0336384145404938 0.329915219531766 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 16/2774 67/18639 0.238805970149254 1.60457984052341 0.0343586650058511 0.334406854064582 GO:0035255 ionotropic glutamate receptor binding 8/2774 27/18639 0.296296296296296 1.99086757990868 0.0380522108856834 0.367549764236715 GO:0030145 manganese ion binding 16/2774 68/18639 0.235294117647059 1.58098307816277 0.0389362168906478 0.368536162756113 GO:0043022 ribosome binding 24/2774 112/18639 0.214285714285714 1.43982387475538 0.0391304069982364 0.368536162756113 GO:0008094 ATP-dependent activity, acting on DNA 41/2774 210/18639 0.195238095238095 1.31183953033268 0.0392378065566452 0.368536162756113 GO:0035591 signaling adaptor activity 27/2774 129/18639 0.209302325581395 1.40633959859828 0.0393631567965058 0.368536162756113 GO:0051879 Hsp90 protein binding 11/2774 42/18639 0.261904761904762 1.75978473581213 0.0395995719981079 0.368536162756113 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 14/2774 58/18639 0.241379310344828 1.62187057156353 0.0422411264667376 0.390271277138336 GO:0016887 ATP hydrolysis activity 75/2774 417/18639 0.179856115107914 1.20848526658126 0.0442877645417765 0.404018771112654 GO:0004602 glutathione peroxidase activity 7/2774 23/18639 0.304347826086957 2.04496724240619 0.0445219260743688 0.404018771112654 GO:0016879 ligase activity, forming carbon-nitrogen bonds 12/2774 48/18639 0.25 1.67979452054795 0.0451689293754572 0.404018771112654 GO:0140693 molecular condensate scaffold activity 12/2774 48/18639 0.25 1.67979452054795 0.0451689293754572 0.404018771112654 GO:0044548 S100 protein binding 5/2774 14/18639 0.357142857142857 2.39970645792564 0.0453134778581251 0.404018771112654 GO:0008375 acetylglucosaminyltransferase activity 11/2774 43/18639 0.255813953488372 1.7188595093979 0.0463088011465097 0.409346984513795 GO:0097718 disordered domain specific binding 8/2774 28/18639 0.285714285714286 1.91976516634051 0.0465531864741179 0.409346984513795 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 9/2774 33/18639 0.272727272727273 1.83250311332503 0.0472484437591276 0.409807930563862 GO:0030296 protein tyrosine kinase activator activity 9/2774 33/18639 0.272727272727273 1.83250311332503 0.0472484437591276 0.409807930563862 GO:0005381 iron ion transmembrane transporter activity 4/2774 10/18639 0.4 2.68767123287671 0.0486789658060552 0.411031002667023 GO:0032356 oxidized DNA binding 4/2774 10/18639 0.4 2.68767123287671 0.0486789658060552 0.411031002667023 GO:0051864 histone H3K36 demethylase activity 4/2774 10/18639 0.4 2.68767123287671 0.0486789658060552 0.411031002667023 GO:0097177 mitochondrial ribosome binding 4/2774 10/18639 0.4 2.68767123287671 0.0486789658060552 0.411031002667023 GO:0140036 ubiquitin-modified protein reader activity 6/2774 19/18639 0.315789473684211 2.12184571016583 0.0518713521383809 0.433492465910576 GO:0035254 glutamate receptor binding 12/2774 49/18639 0.244897959183673 1.64551299972044 0.0520190959092691 0.433492465910576 GO:0003954 NADH dehydrogenase activity 11/2774 44/18639 0.25 1.67979452054795 0.0537521918391739 0.44383548548525 GO:0019207 kinase regulator activity 53/2774 287/18639 0.184668989547038 1.24082382702496 0.0539564707844813 0.44383548548525 GO:0035035 histone acetyltransferase binding 7/2774 24/18639 0.291666666666667 1.9597602739726 0.0550560006455651 0.449976928353176 GO:0030295 protein kinase activator activity 28/2774 139/18639 0.201438848920863 1.35350349857101 0.0557626101161338 0.452592641693926 GO:0016831 carboxy-lyase activity 9/2774 34/18639 0.264705882352941 1.77860596293312 0.0560859901079532 0.452592641693926 GO:0032813 tumor necrosis factor receptor superfamily binding 12/2774 50/18639 0.24 1.61260273972603 0.0595398305415865 0.471362483755379 GO:0140776 protein-containing complex destabilizing activity 5/2774 15/18639 0.333333333333333 2.23972602739726 0.0598907626418599 0.471362483755379 GO:0141050 histone H3K deacetylase activity 5/2774 15/18639 0.333333333333333 2.23972602739726 0.0598907626418599 0.471362483755379 GO:0141051 histone H4K deacetylase activity 5/2774 15/18639 0.333333333333333 2.23972602739726 0.0598907626418599 0.471362483755379 GO:0003779 actin binding 78/2774 443/18639 0.17607223476298 1.18306070070194 0.0613668792373402 0.477070726482246 GO:0046915 transition metal ion transmembrane transporter activity 11/2774 45/18639 0.244444444444444 1.64246575342466 0.0619535196844761 0.477070726482246 GO:0016505 peptidase activator activity involved in apoptotic process 6/2774 20/18639 0.3 2.01575342465753 0.0650976883395612 0.477070726482246 GO:0042054 histone methyltransferase activity 15/2774 67/18639 0.223880597014925 1.5042936004907 0.0651721095888323 0.477070726482246 GO:0034061 DNA polymerase activity 9/2774 35/18639 0.257142857142857 1.72778864970646 0.0659252578019632 0.477070726482246 GO:0042974 nuclear retinoic acid receptor binding 7/2774 25/18639 0.28 1.8813698630137 0.0670136701811954 0.477070726482246 GO:0047617 fatty acyl-CoA hydrolase activity 7/2774 25/18639 0.28 1.8813698630137 0.0670136701811954 0.477070726482246 GO:0035925 mRNA 3'-UTR AU-rich region binding 8/2774 30/18639 0.266666666666667 1.79178082191781 0.0670331313826231 0.477070726482246 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 4/2774 11/18639 0.363636363636364 2.44333748443337 0.0677250624990245 0.477070726482246 GO:0005225 volume-sensitive anion channel activity 4/2774 11/18639 0.363636363636364 2.44333748443337 0.0677250624990245 0.477070726482246 GO:0005536 D-glucose binding 4/2774 11/18639 0.363636363636364 2.44333748443337 0.0677250624990245 0.477070726482246 GO:0019206 nucleoside kinase activity 4/2774 11/18639 0.363636363636364 2.44333748443337 0.0677250624990245 0.477070726482246 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 4/2774 11/18639 0.363636363636364 2.44333748443337 0.0677250624990245 0.477070726482246 GO:0034056 estrogen response element binding 4/2774 11/18639 0.363636363636364 2.44333748443337 0.0677250624990245 0.477070726482246 GO:0042608 T cell receptor binding 4/2774 11/18639 0.363636363636364 2.44333748443337 0.0677250624990245 0.477070726482246 GO:0097493 structural molecule activity conferring elasticity 4/2774 11/18639 0.363636363636364 2.44333748443337 0.0677250624990245 0.477070726482246 GO:0140031 phosphorylation-dependent protein binding 4/2774 11/18639 0.363636363636364 2.44333748443337 0.0677250624990245 0.477070726482246 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 4/2774 11/18639 0.363636363636364 2.44333748443337 0.0677250624990245 0.477070726482246 GO:0043021 ribonucleoprotein complex binding 34/2774 177/18639 0.192090395480226 1.29068957511029 0.0679079449946976 0.477070726482246 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 26/2774 130/18639 0.2 1.34383561643836 0.0680995076233481 0.477070726482246 GO:0016835 carbon-oxygen lyase activity 17/2774 79/18639 0.215189873417722 1.44589908097798 0.0713726770816678 0.497268651798506 GO:0003777 microtubule motor activity 15/2774 68/18639 0.220588235294118 1.4821716357776 0.072597362239262 0.500333172189508 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 15/2774 68/18639 0.220588235294118 1.4821716357776 0.072597362239262 0.500333172189508 GO:0008137 NADH dehydrogenase (ubiquinone) activity 10/2774 41/18639 0.24390243902439 1.6388239224858 0.0739932139174323 0.507211547014657 GO:0106310 protein serine kinase activity 64/2774 361/18639 0.177285318559557 1.19121162675976 0.0745909633979566 0.508574750440613 GO:0005324 long-chain fatty acid transmembrane transporter activity 5/2774 16/18639 0.3125 2.09974315068493 0.076813417445494 0.513267914508636 GO:0008296 3'-5'-DNA exonuclease activity 5/2774 16/18639 0.3125 2.09974315068493 0.076813417445494 0.513267914508636 GO:0055102 lipase inhibitor activity 5/2774 16/18639 0.3125 2.09974315068493 0.076813417445494 0.513267914508636 GO:0140030 modification-dependent protein binding 33/2774 173/18639 0.190751445086705 1.281692928973 0.076919421901956 0.513267914508636 GO:0016758 hexosyltransferase activity 37/2774 197/18639 0.187817258883249 1.26197760934566 0.0772921094789475 0.513267914508636 GO:0005123 death receptor binding 6/2774 21/18639 0.285714285714286 1.91976516634051 0.0801110728840164 0.524948530284575 GO:0016289 acyl-CoA hydrolase activity 7/2774 26/18639 0.269230769230769 1.80900948366702 0.0804085956992783 0.524948530284575 GO:0016279 protein-lysine N-methyltransferase activity 15/2774 69/18639 0.217391304347826 1.460690887433 0.0805585506849909 0.524948530284575 GO:0140938 histone H3 methyltransferase activity 11/2774 47/18639 0.234042553191489 1.57257359370446 0.0806979701457071 0.524948530284575 GO:0008307 structural constituent of muscle 10/2774 42/18639 0.238095238095238 1.59980430528376 0.0847412270172211 0.527907332496015 GO:0140296 general transcription initiation factor binding 12/2774 53/18639 0.226415094339623 1.52132333936418 0.0862838033137795 0.527907332496015 GO:0001618 virus receptor activity 17/2774 81/18639 0.209876543209877 1.41019786910198 0.0863057348605164 0.527907332496015 GO:0016278 lysine N-methyltransferase activity 15/2774 70/18639 0.214285714285714 1.43982387475538 0.0890623252828901 0.527907332496015 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 83/2774 484/18639 0.171487603305785 1.15225574549983 0.0895323860759525 0.527907332496015 GO:0004859 phospholipase inhibitor activity 4/2774 12/18639 0.333333333333333 2.23972602739726 0.090019209850647 0.527907332496015 GO:0016273 arginine N-methyltransferase activity 4/2774 12/18639 0.333333333333333 2.23972602739726 0.090019209850647 0.527907332496015 GO:0016274 protein-arginine N-methyltransferase activity 4/2774 12/18639 0.333333333333333 2.23972602739726 0.090019209850647 0.527907332496015 GO:0031543 peptidyl-proline dioxygenase activity 4/2774 12/18639 0.333333333333333 2.23972602739726 0.090019209850647 0.527907332496015 GO:0034452 dynactin binding 4/2774 12/18639 0.333333333333333 2.23972602739726 0.090019209850647 0.527907332496015 GO:0042301 phosphate ion binding 4/2774 12/18639 0.333333333333333 2.23972602739726 0.090019209850647 0.527907332496015 GO:0043047 single-stranded telomeric DNA binding 4/2774 12/18639 0.333333333333333 2.23972602739726 0.090019209850647 0.527907332496015 GO:0097371 MDM2/MDM4 family protein binding 4/2774 12/18639 0.333333333333333 2.23972602739726 0.090019209850647 0.527907332496015 GO:0001786 phosphatidylserine binding 13/2774 59/18639 0.220338983050847 1.48049686556768 0.090948158501003 0.527907332496015 GO:0031593 polyubiquitin modification-dependent protein binding 13/2774 59/18639 0.220338983050847 1.48049686556768 0.090948158501003 0.527907332496015 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 11/2774 48/18639 0.229166666666667 1.53981164383562 0.0912606579422679 0.527907332496015 GO:0001216 DNA-binding transcription activator activity 84/2774 491/18639 0.171079429735234 1.14951315459085 0.0918516504441127 0.527907332496015 GO:0140272 exogenous protein binding 17/2774 82/18639 0.207317073170732 1.39300033411293 0.0944746940183115 0.527907332496015 GO:1902936 phosphatidylinositol bisphosphate binding 22/2774 111/18639 0.198198198198198 1.33172898926324 0.0946525596800099 0.527907332496015 GO:0001671 ATPase activator activity 7/2774 27/18639 0.259259259259259 1.74200913242009 0.0952333303840365 0.527907332496015 GO:0070403 NAD+ binding 5/2774 17/18639 0.294117647058824 1.97622884770346 0.0960220497286433 0.527907332496015 GO:0048156 tau protein binding 10/2774 43/18639 0.232558139534884 1.56259955399809 0.0963874166750123 0.527907332496015 GO:0016651 oxidoreductase activity, acting on NAD(P)H 18/2774 88/18639 0.204545454545455 1.37437733499377 0.0965648325640172 0.527907332496015 GO:0008093 cytoskeletal anchor activity 6/2774 22/18639 0.272727272727273 1.83250311332503 0.0968865221992687 0.527907332496015 GO:0032931 histone H3K56 acetyltransferase activity 6/2774 22/18639 0.272727272727273 1.83250311332503 0.0968865221992687 0.527907332496015 GO:0043992 histone H3K9 acetyltransferase activity 6/2774 22/18639 0.272727272727273 1.83250311332503 0.0968865221992687 0.527907332496015 GO:0043993 histone H3K18 acetyltransferase activity 6/2774 22/18639 0.272727272727273 1.83250311332503 0.0968865221992687 0.527907332496015 GO:0043994 histone H3K23 acetyltransferase activity 6/2774 22/18639 0.272727272727273 1.83250311332503 0.0968865221992687 0.527907332496015 GO:0043999 histone H2AK5 acetyltransferase activity 6/2774 22/18639 0.272727272727273 1.83250311332503 0.0968865221992687 0.527907332496015 GO:0044012 histone H2AK9 acetyltransferase activity 6/2774 22/18639 0.272727272727273 1.83250311332503 0.0968865221992687 0.527907332496015 GO:0044014 histone H2BK5 acetyltransferase activity 6/2774 22/18639 0.272727272727273 1.83250311332503 0.0968865221992687 0.527907332496015 GO:0044015 histone H2BK12 acetyltransferase activity 6/2774 22/18639 0.272727272727273 1.83250311332503 0.0968865221992687 0.527907332496015 GO:0044016 histone H3K4 acetyltransferase activity 6/2774 22/18639 0.272727272727273 1.83250311332503 0.0968865221992687 0.527907332496015 GO:0044017 histone H3K27 acetyltransferase activity 6/2774 22/18639 0.272727272727273 1.83250311332503 0.0968865221992687 0.527907332496015 GO:0044018 histone H3K36 acetyltransferase activity 6/2774 22/18639 0.272727272727273 1.83250311332503 0.0968865221992687 0.527907332496015 GO:0046972 histone H4K16 acetyltransferase activity 6/2774 22/18639 0.272727272727273 1.83250311332503 0.0968865221992687 0.527907332496015 GO:0140035 ubiquitin-like protein reader activity 6/2774 22/18639 0.272727272727273 1.83250311332503 0.0968865221992687 0.527907332496015 GO:0140908 histone H3K122 acetyltransferase activity 6/2774 22/18639 0.272727272727273 1.83250311332503 0.0968865221992687 0.527907332496015 GO:0003713 transcription coactivator activity 46/2774 256/18639 0.1796875 1.20735231164384 0.0974807591795547 0.528884970016733 GO:0001222 transcription corepressor binding 11/2774 49/18639 0.224489795918367 1.5083869164104 0.102620057478136 0.552069929470986 GO:0060590 ATPase regulator activity 11/2774 49/18639 0.224489795918367 1.5083869164104 0.102620057478136 0.552069929470986 GO:0016779 nucleotidyltransferase activity 26/2774 136/18639 0.191176470588235 1.28454875100725 0.104251210994801 0.558063547102536 GO:0019209 kinase activator activity 28/2774 148/18639 0.189189189189189 1.27119585338763 0.104609559025495 0.558063547102536 GO:0051015 actin filament binding 38/2774 209/18639 0.181818181818182 1.22166874221669 0.107629138501073 0.571779798286949 GO:0046966 nuclear thyroid hormone receptor binding 7/2774 28/18639 0.25 1.67979452054795 0.111460045020676 0.58645122193037 GO:0051019 mitogen-activated protein kinase binding 7/2774 28/18639 0.25 1.67979452054795 0.111460045020676 0.58645122193037 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 13/2774 61/18639 0.213114754098361 1.4319559847294 0.111789467995443 0.58645122193037 GO:0004860 protein kinase inhibitor activity 17/2774 84/18639 0.202380952380952 1.35983365949119 0.112230665216479 0.58645122193037 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 4/2774 13/18639 0.307692307692308 2.06743940990516 0.115324289899656 0.593122516372067 GO:0008035 high-density lipoprotein particle binding 4/2774 13/18639 0.307692307692308 2.06743940990516 0.115324289899656 0.593122516372067 GO:0019104 DNA N-glycosylase activity 4/2774 13/18639 0.307692307692308 2.06743940990516 0.115324289899656 0.593122516372067 GO:0044013 histone H2B acetyltransferase activity 6/2774 23/18639 0.260869565217391 1.75282906491959 0.115368144360998 0.593122516372067 GO:0008525 phosphatidylcholine transporter activity 5/2774 18/18639 0.277777777777778 1.86643835616438 0.1174059612681 0.598770402467312 GO:0070064 proline-rich region binding 5/2774 18/18639 0.277777777777778 1.86643835616438 0.1174059612681 0.598770402467312 GO:0046332 SMAD binding 16/2774 79/18639 0.20253164556962 1.36084619386163 0.12005349552218 0.609833493190355 GO:0072341 modified amino acid binding 18/2774 91/18639 0.197802197802198 1.32906819208189 0.123214066634376 0.623404503804879 GO:0003678 DNA helicase activity 15/2774 74/18639 0.202702702702703 1.36199555720104 0.128541608315561 0.647748959307887 GO:0010484 histone H3 acetyltransferase activity 7/2774 29/18639 0.241379310344828 1.62187057156353 0.12904175346212 0.647748959307887 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 9/2774 40/18639 0.225 1.51181506849315 0.130417414721525 0.649539858476343 GO:0030331 nuclear estrogen receptor binding 9/2774 40/18639 0.225 1.51181506849315 0.130417414721525 0.649539858476343 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 17/2774 86/18639 0.197674418604651 1.32820962089838 0.131871179514486 0.654224723272253 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 23/2774 122/18639 0.188524590163934 1.2667302941837 0.134868321425196 0.664334788997429 GO:0015295 solute:proton symporter activity 6/2774 24/18639 0.25 1.67979452054795 0.135472192266142 0.664334788997429 GO:0043998 histone H2A acetyltransferase activity 6/2774 24/18639 0.25 1.67979452054795 0.135472192266142 0.664334788997429 GO:0004674 protein serine/threonine kinase activity 73/2774 433/18639 0.168591224018476 1.13279445727483 0.136072543433552 0.664722194934019 GO:0140566 histone reader activity 8/2774 35/18639 0.228571428571429 1.53581213307241 0.13896220961351 0.676247394111545 GO:0005346 purine ribonucleotide transmembrane transporter activity 5/2774 19/18639 0.263157894736842 1.76820475847152 0.140811178814429 0.677487747126024 GO:0015245 fatty acid transmembrane transporter activity 5/2774 19/18639 0.263157894736842 1.76820475847152 0.140811178814429 0.677487747126024 GO:0046527 glucosyltransferase activity 5/2774 19/18639 0.263157894736842 1.76820475847152 0.140811178814429 0.677487747126024 GO:0005080 protein kinase C binding 11/2774 52/18639 0.211538461538462 1.4213645943098 0.141395808873847 0.677743068850207 GO:0032036 myosin heavy chain binding 4/2774 14/18639 0.285714285714286 1.91976516634051 0.143328614716269 0.679345664547373 GO:0034236 protein kinase A catalytic subunit binding 4/2774 14/18639 0.285714285714286 1.91976516634051 0.143328614716269 0.679345664547373 GO:0098847 sequence-specific single stranded DNA binding 4/2774 14/18639 0.285714285714286 1.91976516634051 0.143328614716269 0.679345664547373 GO:0016769 transferase activity, transferring nitrogenous groups 7/2774 30/18639 0.233333333333333 1.56780821917808 0.147913942790663 0.698482507622574 GO:0004197 cysteine-type endopeptidase activity 17/2774 88/18639 0.193181818181818 1.29802303860523 0.153359799588117 0.721526732379517 GO:0016251 RNA polymerase II general transcription initiation factor activity 11/2774 53/18639 0.207547169811321 1.39454639441716 0.155829905568151 0.726844176046761 GO:0055106 ubiquitin-protein transferase regulator activity 8/2774 36/18639 0.222222222222222 1.49315068493151 0.156727348336231 0.726844176046761 GO:0000030 mannosyltransferase activity 6/2774 25/18639 0.24 1.61260273972603 0.157090672924547 0.726844176046761 GO:0003707 nuclear steroid receptor activity 6/2774 25/18639 0.24 1.61260273972603 0.157090672924547 0.726844176046761 GO:0004386 helicase activity 28/2774 155/18639 0.180645161290323 1.21378700839593 0.157420097410239 0.726844176046761 GO:0004879 nuclear receptor activity 12/2774 59/18639 0.203389830508475 1.36661249129324 0.158866491566267 0.726844176046761 GO:0019894 kinesin binding 9/2774 42/18639 0.214285714285714 1.43982387475538 0.163071855974163 0.726844176046761 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 17/2774 89/18639 0.191011235955056 1.28343851008158 0.164776775504387 0.726844176046761 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 17/2774 89/18639 0.191011235955056 1.28343851008158 0.164776775504387 0.726844176046761 GO:0043024 ribosomal small subunit binding 5/2774 20/18639 0.25 1.67979452054795 0.166049008972718 0.726844176046761 GO:0140939 histone H4 methyltransferase activity 5/2774 20/18639 0.25 1.67979452054795 0.166049008972718 0.726844176046761 GO:0140463 chromatin-protein adaptor activity 11/2774 54/18639 0.203703703703704 1.36872146118721 0.170975974171526 0.726844176046761 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 24/2774 132/18639 0.181818181818182 1.22166874221669 0.17108090223629 0.726844176046761 GO:0098531 ligand-modulated transcription factor activity 12/2774 60/18639 0.2 1.34383561643836 0.173321983929376 0.726844176046761 GO:0000774 adenyl-nucleotide exchange factor activity 4/2774 15/18639 0.266666666666667 1.79178082191781 0.173669651834236 0.726844176046761 GO:0004129 cytochrome-c oxidase activity 4/2774 15/18639 0.266666666666667 1.79178082191781 0.173669651834236 0.726844176046761 GO:0004559 alpha-mannosidase activity 4/2774 15/18639 0.266666666666667 1.79178082191781 0.173669651834236 0.726844176046761 GO:0010181 FMN binding 4/2774 15/18639 0.266666666666667 1.79178082191781 0.173669651834236 0.726844176046761 GO:0016846 carbon-sulfur lyase activity 4/2774 15/18639 0.266666666666667 1.79178082191781 0.173669651834236 0.726844176046761 GO:0031005 filamin binding 4/2774 15/18639 0.266666666666667 1.79178082191781 0.173669651834236 0.726844176046761 GO:0050700 CARD domain binding 4/2774 15/18639 0.266666666666667 1.79178082191781 0.173669651834236 0.726844176046761 GO:0055105 ubiquitin-protein transferase inhibitor activity 4/2774 15/18639 0.266666666666667 1.79178082191781 0.173669651834236 0.726844176046761 GO:0019210 kinase inhibitor activity 17/2774 90/18639 0.188888888888889 1.26917808219178 0.176627337670664 0.726844176046761 GO:0140793 histone H2AXY142 phosphatase activity 17/2774 90/18639 0.188888888888889 1.26917808219178 0.176627337670664 0.726844176046761 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 3/2774 10/18639 0.3 2.01575342465753 0.176722897705487 0.726844176046761 GO:0015924 mannosyl-oligosaccharide mannosidase activity 3/2774 10/18639 0.3 2.01575342465753 0.176722897705487 0.726844176046761 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 3/2774 10/18639 0.3 2.01575342465753 0.176722897705487 0.726844176046761 GO:0016889 DNA endonuclease activity, producing 3'-phosphomonoesters 3/2774 10/18639 0.3 2.01575342465753 0.176722897705487 0.726844176046761 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 3/2774 10/18639 0.3 2.01575342465753 0.176722897705487 0.726844176046761 GO:0019911 structural constituent of myelin sheath 3/2774 10/18639 0.3 2.01575342465753 0.176722897705487 0.726844176046761 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 3/2774 10/18639 0.3 2.01575342465753 0.176722897705487 0.726844176046761 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 3/2774 10/18639 0.3 2.01575342465753 0.176722897705487 0.726844176046761 GO:0043295 glutathione binding 3/2774 10/18639 0.3 2.01575342465753 0.176722897705487 0.726844176046761 GO:0047429 nucleoside triphosphate diphosphatase activity 3/2774 10/18639 0.3 2.01575342465753 0.176722897705487 0.726844176046761 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 3/2774 10/18639 0.3 2.01575342465753 0.176722897705487 0.726844176046761 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 3/2774 10/18639 0.3 2.01575342465753 0.176722897705487 0.726844176046761 GO:1905394 retromer complex binding 3/2774 10/18639 0.3 2.01575342465753 0.176722897705487 0.726844176046761 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 3/2774 10/18639 0.3 2.01575342465753 0.176722897705487 0.726844176046761 GO:1990757 ubiquitin ligase activator activity 3/2774 10/18639 0.3 2.01575342465753 0.176722897705487 0.726844176046761 GO:0008194 UDP-glycosyltransferase activity 26/2774 145/18639 0.179310344827586 1.20481813887577 0.177963672696015 0.72959383500778 GO:0004435 phosphatidylinositol phospholipase C activity 6/2774 26/18639 0.230769230769231 1.55057955742887 0.180095296092127 0.733615024017451 GO:0034237 protein kinase A regulatory subunit binding 6/2774 26/18639 0.230769230769231 1.55057955742887 0.180095296092127 0.733615024017451 GO:0004712 protein serine/threonine/tyrosine kinase activity 9/2774 43/18639 0.209302325581395 1.40633959859828 0.180723619318056 0.73382998289975 GO:0035401 histone H3Y41 kinase activity 21/2774 115/18639 0.182608695652174 1.22698034544372 0.184951047876029 0.746242360892206 GO:0140801 histone H2AXY142 kinase activity 21/2774 115/18639 0.182608695652174 1.22698034544372 0.184951047876029 0.746242360892206 GO:0016836 hydro-lyase activity 12/2774 61/18639 0.19672131147541 1.3218055243656 0.188391171505033 0.753641534126831 GO:0015106 bicarbonate transmembrane transporter activity 7/2774 32/18639 0.21875 1.46982020547945 0.189195925758762 0.753641534126831 GO:0043425 bHLH transcription factor binding 7/2774 32/18639 0.21875 1.46982020547945 0.189195925758762 0.753641534126831 GO:0051059 NF-kappaB binding 7/2774 32/18639 0.21875 1.46982020547945 0.189195925758762 0.753641534126831 GO:0043539 protein serine/threonine kinase activator activity 14/2774 73/18639 0.191780821917808 1.28860949521486 0.189740339180167 0.753641534126831 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 5/2774 21/18639 0.238095238095238 1.59980430528376 0.192904614000437 0.756779639540175 GO:0010314 phosphatidylinositol-5-phosphate binding 5/2774 21/18639 0.238095238095238 1.59980430528376 0.192904614000437 0.756779639540175 GO:0051010 microtubule plus-end binding 5/2774 21/18639 0.238095238095238 1.59980430528376 0.192904614000437 0.756779639540175 GO:0070182 DNA polymerase binding 5/2774 21/18639 0.238095238095238 1.59980430528376 0.192904614000437 0.756779639540175 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 8/2774 38/18639 0.210526315789474 1.41456380677722 0.195213556922411 0.758833186207541 GO:0042162 telomeric DNA binding 8/2774 38/18639 0.210526315789474 1.41456380677722 0.195213556922411 0.758833186207541 GO:0042887 amide transmembrane transporter activity 8/2774 38/18639 0.210526315789474 1.41456380677722 0.195213556922411 0.758833186207541 GO:0016790 thiolester hydrolase activity 9/2774 44/18639 0.204545454545455 1.37437733499377 0.199185558623557 0.771919718070015 GO:0004364 glutathione transferase activity 6/2774 27/18639 0.222222222222222 1.49315068493151 0.204341572008725 0.781525909832937 GO:0005385 zinc ion transmembrane transporter activity 6/2774 27/18639 0.222222222222222 1.49315068493151 0.204341572008725 0.781525909832937 GO:0003688 DNA replication origin binding 4/2774 16/18639 0.25 1.67979452054795 0.20595506329715 0.781525909832937 GO:0015923 mannosidase activity 4/2774 16/18639 0.25 1.67979452054795 0.20595506329715 0.781525909832937 GO:0016675 oxidoreductase activity, acting on a heme group of donors 4/2774 16/18639 0.25 1.67979452054795 0.20595506329715 0.781525909832937 GO:0017070 U6 snRNA binding 4/2774 16/18639 0.25 1.67979452054795 0.20595506329715 0.781525909832937 GO:0140328 floppase activity 4/2774 16/18639 0.25 1.67979452054795 0.20595506329715 0.781525909832937 GO:0002020 protease binding 24/2774 136/18639 0.176470588235294 1.18573730862208 0.212148498137513 0.790166328144299 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 8/2774 39/18639 0.205128205128205 1.37829293993678 0.215783497483617 0.790166328144299 GO:0008081 phosphoric diester hydrolase activity 16/2774 87/18639 0.183908045977011 1.23571091166745 0.216190799720116 0.790166328144299 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 3/2774 11/18639 0.272727272727273 1.83250311332503 0.21759708590791 0.790166328144299 GO:0002162 dystroglycan binding 3/2774 11/18639 0.272727272727273 1.83250311332503 0.21759708590791 0.790166328144299 GO:0015217 ADP transmembrane transporter activity 3/2774 11/18639 0.272727272727273 1.83250311332503 0.21759708590791 0.790166328144299 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 3/2774 11/18639 0.272727272727273 1.83250311332503 0.21759708590791 0.790166328144299 GO:0019215 intermediate filament binding 3/2774 11/18639 0.272727272727273 1.83250311332503 0.21759708590791 0.790166328144299 GO:0032404 mismatch repair complex binding 3/2774 11/18639 0.272727272727273 1.83250311332503 0.21759708590791 0.790166328144299 GO:0032794 GTPase activating protein binding 3/2774 11/18639 0.272727272727273 1.83250311332503 0.21759708590791 0.790166328144299 GO:0043522 leucine zipper domain binding 3/2774 11/18639 0.272727272727273 1.83250311332503 0.21759708590791 0.790166328144299 GO:0045294 alpha-catenin binding 3/2774 11/18639 0.272727272727273 1.83250311332503 0.21759708590791 0.790166328144299 GO:1900750 oligopeptide binding 3/2774 11/18639 0.272727272727273 1.83250311332503 0.21759708590791 0.790166328144299 GO:1990948 ubiquitin ligase inhibitor activity 3/2774 11/18639 0.272727272727273 1.83250311332503 0.21759708590791 0.790166328144299 GO:0004715 non-membrane spanning protein tyrosine kinase activity 9/2774 45/18639 0.2 1.34383561643836 0.218394889036553 0.790166328144299 GO:0051539 4 iron, 4 sulfur cluster binding 9/2774 45/18639 0.2 1.34383561643836 0.218394889036553 0.790166328144299 GO:0003725 double-stranded RNA binding 14/2774 75/18639 0.186666666666667 1.25424657534247 0.218767618694069 0.790166328144299 GO:0004601 peroxidase activity 11/2774 57/18639 0.192982456140351 1.29668348954578 0.220331675519603 0.793567475388401 GO:0016881 acid-amino acid ligase activity 5/2774 22/18639 0.227272727272727 1.52708592777086 0.221145229236075 0.794253992326747 GO:0036408 histone H3K14 acetyltransferase activity 6/2774 28/18639 0.214285714285714 1.43982387475538 0.22967289755092 0.801103579364548 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 6/2774 28/18639 0.214285714285714 1.43982387475538 0.22967289755092 0.801103579364548 GO:0140597 protein carrier chaperone 32/2774 188/18639 0.170212765957447 1.14368988633052 0.23077333549604 0.801103579364548 GO:0140034 methylation-dependent protein binding 14/2774 76/18639 0.184210526315789 1.23774333093006 0.233955096897288 0.801103579364548 GO:0097110 scaffold protein binding 13/2774 70/18639 0.185714285714286 1.24784735812133 0.235584050726469 0.801103579364548 GO:0004532 RNA exonuclease activity 8/2774 40/18639 0.2 1.34383561643836 0.23712501817414 0.801103579364548 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 8/2774 40/18639 0.2 1.34383561643836 0.23712501817414 0.801103579364548 GO:0071949 FAD binding 8/2774 40/18639 0.2 1.34383561643836 0.23712501817414 0.801103579364548 GO:0017116 single-stranded DNA helicase activity 11/2774 58/18639 0.189655172413793 1.27432687765706 0.237950184120515 0.801103579364548 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 9/2774 46/18639 0.195652173913043 1.3146217986897 0.238283464107018 0.801103579364548 GO:0030276 clathrin binding 9/2774 46/18639 0.195652173913043 1.3146217986897 0.238283464107018 0.801103579364548 GO:0030291 protein serine/threonine kinase inhibitor activity 9/2774 46/18639 0.195652173913043 1.3146217986897 0.238283464107018 0.801103579364548 GO:0004659 prenyltransferase activity 4/2774 17/18639 0.235294117647059 1.58098307816277 0.239780605933614 0.801103579364548 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 4/2774 17/18639 0.235294117647059 1.58098307816277 0.239780605933614 0.801103579364548 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 4/2774 17/18639 0.235294117647059 1.58098307816277 0.239780605933614 0.801103579364548 GO:0016805 dipeptidase activity 4/2774 17/18639 0.235294117647059 1.58098307816277 0.239780605933614 0.801103579364548 GO:0019198 transmembrane receptor protein phosphatase activity 4/2774 17/18639 0.235294117647059 1.58098307816277 0.239780605933614 0.801103579364548 GO:0045125 bioactive lipid receptor activity 4/2774 17/18639 0.235294117647059 1.58098307816277 0.239780605933614 0.801103579364548 GO:0046965 nuclear retinoid X receptor binding 4/2774 17/18639 0.235294117647059 1.58098307816277 0.239780605933614 0.801103579364548 GO:0048038 quinone binding 4/2774 17/18639 0.235294117647059 1.58098307816277 0.239780605933614 0.801103579364548 GO:0070402 NADPH binding 4/2774 17/18639 0.235294117647059 1.58098307816277 0.239780605933614 0.801103579364548 GO:0140658 ATP-dependent chromatin remodeler activity 27/2774 158/18639 0.170886075949367 1.14821397607075 0.246887051362634 0.801103579364548 GO:0030165 PDZ domain binding 15/2774 83/18639 0.180722891566265 1.21430929196237 0.24705946623 0.801103579364548 GO:0015616 DNA translocase activity 26/2774 152/18639 0.171052631578947 1.14933309300649 0.250319636293263 0.801103579364548 GO:0000295 adenine nucleotide transmembrane transporter activity 5/2774 23/18639 0.217391304347826 1.460690887433 0.250527752812485 0.801103579364548 GO:0008171 O-methyltransferase activity 5/2774 23/18639 0.217391304347826 1.460690887433 0.250527752812485 0.801103579364548 GO:0043274 phospholipase binding 5/2774 23/18639 0.217391304347826 1.460690887433 0.250527752812485 0.801103579364548 GO:0004540 RNA nuclease activity 21/2774 121/18639 0.173553719008264 1.1661383448432 0.255908582255831 0.801103579364548 GO:0004629 phospholipase C activity 6/2774 29/18639 0.206896551724138 1.39017477562589 0.255924500356693 0.801103579364548 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 6/2774 29/18639 0.206896551724138 1.39017477562589 0.255924500356693 0.801103579364548 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 6/2774 29/18639 0.206896551724138 1.39017477562589 0.255924500356693 0.801103579364548 GO:0097472 cyclin-dependent protein kinase activity 6/2774 29/18639 0.206896551724138 1.39017477562589 0.255924500356693 0.801103579364548 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 11/2774 59/18639 0.186440677966102 1.25272811701881 0.256073530330864 0.801103579364548 GO:0045309 protein phosphorylated amino acid binding 11/2774 59/18639 0.186440677966102 1.25272811701881 0.256073530330864 0.801103579364548 GO:0070063 RNA polymerase binding 11/2774 59/18639 0.186440677966102 1.25272811701881 0.256073530330864 0.801103579364548 GO:0004713 protein tyrosine kinase activity 24/2774 140/18639 0.171428571428571 1.15185909980431 0.25741724447859 0.801103579364548 GO:0004864 protein phosphatase inhibitor activity 10/2774 53/18639 0.188679245283019 1.26776944947015 0.257676805373624 0.801103579364548 GO:0051018 protein kinase A binding 10/2774 53/18639 0.188679245283019 1.26776944947015 0.257676805373624 0.801103579364548 GO:0000175 3'-5'-RNA exonuclease activity 7/2774 35/18639 0.2 1.34383561643836 0.258406604552977 0.801103579364548 GO:0005154 epidermal growth factor receptor binding 7/2774 35/18639 0.2 1.34383561643836 0.258406604552977 0.801103579364548 GO:0010485 histone H4 acetyltransferase activity 7/2774 35/18639 0.2 1.34383561643836 0.258406604552977 0.801103579364548 GO:0043015 gamma-tubulin binding 7/2774 35/18639 0.2 1.34383561643836 0.258406604552977 0.801103579364548 GO:0001784 phosphotyrosine residue binding 9/2774 47/18639 0.191489361702128 1.28665112212183 0.258778773385701 0.801103579364548 GO:0001727 lipid kinase activity 8/2774 41/18639 0.195121951219512 1.31105913798864 0.259146423501767 0.801103579364548 GO:0005025 transforming growth factor beta receptor activity, type I 3/2774 12/18639 0.25 1.67979452054795 0.260123044593665 0.801103579364548 GO:0005026 transforming growth factor beta receptor activity, type II 3/2774 12/18639 0.25 1.67979452054795 0.260123044593665 0.801103579364548 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 3/2774 12/18639 0.25 1.67979452054795 0.260123044593665 0.801103579364548 GO:0016208 AMP binding 3/2774 12/18639 0.25 1.67979452054795 0.260123044593665 0.801103579364548 GO:0016361 activin receptor activity, type I 3/2774 12/18639 0.25 1.67979452054795 0.260123044593665 0.801103579364548 GO:0016362 activin receptor activity, type II 3/2774 12/18639 0.25 1.67979452054795 0.260123044593665 0.801103579364548 GO:0016840 carbon-nitrogen lyase activity 3/2774 12/18639 0.25 1.67979452054795 0.260123044593665 0.801103579364548 GO:0017002 activin receptor activity 3/2774 12/18639 0.25 1.67979452054795 0.260123044593665 0.801103579364548 GO:0035251 UDP-glucosyltransferase activity 3/2774 12/18639 0.25 1.67979452054795 0.260123044593665 0.801103579364548 GO:0035259 nuclear glucocorticoid receptor binding 3/2774 12/18639 0.25 1.67979452054795 0.260123044593665 0.801103579364548 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 3/2774 12/18639 0.25 1.67979452054795 0.260123044593665 0.801103579364548 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 3/2774 12/18639 0.25 1.67979452054795 0.260123044593665 0.801103579364548 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 3/2774 12/18639 0.25 1.67979452054795 0.260123044593665 0.801103579364548 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 3/2774 12/18639 0.25 1.67979452054795 0.260123044593665 0.801103579364548 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 3/2774 12/18639 0.25 1.67979452054795 0.260123044593665 0.801103579364548 GO:0009055 electron transfer activity 20/2774 116/18639 0.172413793103448 1.15847897968824 0.272635495011297 0.834046684304274 GO:0000900 mRNA regulatory element binding translation repressor activity 4/2774 18/18639 0.222222222222222 1.49315068493151 0.274744790123761 0.834046684304274 GO:0015172 acidic amino acid transmembrane transporter activity 4/2774 18/18639 0.222222222222222 1.49315068493151 0.274744790123761 0.834046684304274 GO:0016854 racemase and epimerase activity 4/2774 18/18639 0.222222222222222 1.49315068493151 0.274744790123761 0.834046684304274 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 4/2774 18/18639 0.222222222222222 1.49315068493151 0.274744790123761 0.834046684304274 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 4/2774 18/18639 0.222222222222222 1.49315068493151 0.274744790123761 0.834046684304274 GO:0050661 NADP binding 10/2774 54/18639 0.185185185185185 1.24429223744292 0.277381539737738 0.840050981391012 GO:0016853 isomerase activity 30/2774 180/18639 0.166666666666667 1.11986301369863 0.278717163689014 0.842095695979839 GO:0043175 RNA polymerase core enzyme binding 8/2774 42/18639 0.19047619047619 1.27984344422701 0.281752204096498 0.846788974598489 GO:0043995 histone H4K5 acetyltransferase activity 6/2774 30/18639 0.2 1.34383561643836 0.282927139748201 0.846788974598489 GO:0043996 histone H4K8 acetyltransferase activity 6/2774 30/18639 0.2 1.34383561643836 0.282927139748201 0.846788974598489 GO:0043997 histone H4K12 acetyltransferase activity 6/2774 30/18639 0.2 1.34383561643836 0.282927139748201 0.846788974598489 GO:0004725 protein tyrosine phosphatase activity 17/2774 98/18639 0.173469387755102 1.16557170813531 0.285062386370392 0.849365752307992 GO:0004521 RNA endonuclease activity 13/2774 73/18639 0.178082191780822 1.19656595984237 0.285762426112751 0.849365752307992 GO:0140789 histone phosphatase activity 23/2774 136/18639 0.169117647058824 1.13633158742949 0.285786594305983 0.849365752307992 GO:0022853 active monoatomic ion transmembrane transporter activity 20/2774 118/18639 0.169491525423729 1.13884374274437 0.299750932097151 0.879641830744048 GO:0019842 vitamin binding 25/2774 150/18639 0.166666666666667 1.11986301369863 0.301238349695432 0.879641830744048 GO:0031491 nucleosome binding 13/2774 74/18639 0.175675675675676 1.18039614957423 0.303182933978886 0.879641830744048 GO:0035064 methylated histone binding 13/2774 74/18639 0.175675675675676 1.18039614957423 0.303182933978886 0.879641830744048 GO:0048029 monosaccharide binding 13/2774 74/18639 0.175675675675676 1.18039614957423 0.303182933978886 0.879641830744048 GO:0005338 nucleotide-sugar transmembrane transporter activity 3/2774 13/18639 0.230769230769231 1.55057955742887 0.303562671001868 0.879641830744048 GO:0008253 5'-nucleotidase activity 3/2774 13/18639 0.230769230769231 1.55057955742887 0.303562671001868 0.879641830744048 GO:0046975 histone H3K36 methyltransferase activity 3/2774 13/18639 0.230769230769231 1.55057955742887 0.303562671001868 0.879641830744048 GO:0051011 microtubule minus-end binding 3/2774 13/18639 0.230769230769231 1.55057955742887 0.303562671001868 0.879641830744048 GO:0070123 transforming growth factor beta receptor activity, type III 3/2774 13/18639 0.230769230769231 1.55057955742887 0.303562671001868 0.879641830744048 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 3/2774 13/18639 0.230769230769231 1.55057955742887 0.303562671001868 0.879641830744048 GO:0140223 general transcription initiation factor activity 12/2774 68/18639 0.176470588235294 1.18573730862208 0.308008292022458 0.888522499079462 GO:0023023 MHC protein complex binding 7/2774 37/18639 0.189189189189189 1.27119585338763 0.308021133014214 0.888522499079462 GO:0140457 protein demethylase activity 6/2774 31/18639 0.193548387096774 1.30048608042422 0.310510490423737 0.890318857636973 GO:0008483 transaminase activity 5/2774 25/18639 0.2 1.34383561643836 0.311734246648398 0.890318857636973 GO:0017025 TBP-class protein binding 5/2774 25/18639 0.2 1.34383561643836 0.311734246648398 0.890318857636973 GO:0000510 H3-H4 histone complex chaperone activity 25/2774 151/18639 0.165562913907285 1.11244670234963 0.313531895748236 0.890318857636973 GO:0140584 chromatin extrusion motor activity 25/2774 151/18639 0.165562913907285 1.11244670234963 0.313531895748236 0.890318857636973 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 25/2774 151/18639 0.165562913907285 1.11244670234963 0.313531895748236 0.890318857636973 GO:0140849 ATP-dependent H2AZ histone chaperone activity 25/2774 151/18639 0.165562913907285 1.11244670234963 0.313531895748236 0.890318857636973 GO:0140713 histone chaperone activity 27/2774 164/18639 0.164634146341463 1.10620614767792 0.315320471411496 0.891594737724234 GO:0015101 organic cation transmembrane transporter activity 14/2774 81/18639 0.172839506172839 1.16133942161339 0.315379785657749 0.891594737724234 GO:0019212 phosphatase inhibitor activity 10/2774 56/18639 0.178571428571429 1.19985322896282 0.317998386367353 0.895028570901489 GO:0030170 pyridoxal phosphate binding 10/2774 56/18639 0.178571428571429 1.19985322896282 0.317998386367353 0.895028570901489 GO:0015605 organophosphate ester transmembrane transporter activity 9/2774 50/18639 0.18 1.20945205479452 0.323135499110165 0.907484055871058 GO:0140104 molecular carrier activity 40/2774 249/18639 0.160642570281124 1.07938603729988 0.324883162243464 0.910386883209705 GO:0140674 ATP-dependent histone chaperone activity 25/2774 152/18639 0.164473684210526 1.1051279740447 0.325975253908663 0.911443966520934 GO:0015078 proton transmembrane transporter activity 30/2774 185/18639 0.162162162162162 1.08959644576083 0.334327817274675 0.93275266307486 GO:0061775 cohesin loader activity 25/2774 153/18639 0.163398692810458 1.09790491539081 0.338554491494019 0.93505631700821 GO:0015932 nucleobase-containing compound transmembrane transporter activity 10/2774 57/18639 0.175438596491228 1.17880317231435 0.338778537611555 0.93505631700821 GO:0016504 peptidase activator activity 10/2774 57/18639 0.175438596491228 1.17880317231435 0.338778537611555 0.93505631700821 GO:0070279 vitamin B6 binding 10/2774 57/18639 0.175438596491228 1.17880317231435 0.338778537611555 0.93505631700821 GO:0051536 iron-sulfur cluster binding 13/2774 76/18639 0.171052631578947 1.14933309300649 0.338820406633563 0.93505631700821 GO:0008157 protein phosphatase 1 binding 5/2774 26/18639 0.192307692307692 1.29214963119073 0.3430768539237 0.936067985026638 GO:0015216 purine nucleotide transmembrane transporter activity 5/2774 26/18639 0.192307692307692 1.29214963119073 0.3430768539237 0.936067985026638 GO:0003689 DNA clamp loader activity 26/2774 160/18639 0.1625 1.09186643835616 0.345204855844744 0.936067985026638 GO:0042288 MHC class I protein binding 4/2774 20/18639 0.2 1.34383561643836 0.346563272514633 0.936067985026638 GO:0005347 ATP transmembrane transporter activity 3/2774 14/18639 0.214285714285714 1.43982387475538 0.347262868170666 0.936067985026638 GO:0005545 1-phosphatidylinositol binding 3/2774 14/18639 0.214285714285714 1.43982387475538 0.347262868170666 0.936067985026638 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 3/2774 14/18639 0.214285714285714 1.43982387475538 0.347262868170666 0.936067985026638 GO:0032454 histone H3K9 demethylase activity 3/2774 14/18639 0.214285714285714 1.43982387475538 0.347262868170666 0.936067985026638 GO:0070742 C2H2 zinc finger domain binding 3/2774 14/18639 0.214285714285714 1.43982387475538 0.347262868170666 0.936067985026638 GO:0098821 BMP receptor activity 3/2774 14/18639 0.214285714285714 1.43982387475538 0.347262868170666 0.936067985026638 GO:1901612 cardiolipin binding 3/2774 14/18639 0.214285714285714 1.43982387475538 0.347262868170666 0.936067985026638 GO:0001221 transcription coregulator binding 19/2774 115/18639 0.165217391304348 1.11012507444908 0.348240670232002 0.936723321826587 GO:0008135 translation factor activity, RNA binding 14/2774 83/18639 0.168674698795181 1.13335533916488 0.349859621605708 0.939096879046901 GO:0016874 ligase activity 27/2774 167/18639 0.161676646706587 1.08633418095316 0.351559623504393 0.941197618142381 GO:0004896 cytokine receptor activity 16/2774 96/18639 0.166666666666667 1.11986301369863 0.352856832527104 0.941197618142381 GO:0016407 acetyltransferase activity 16/2774 96/18639 0.166666666666667 1.11986301369863 0.352856832527104 0.941197618142381 GO:0051540 metal cluster binding 13/2774 77/18639 0.168831168831169 1.13440668920121 0.356952966293475 0.949358382359678 GO:0008234 cysteine-type peptidase activity 30/2774 187/18639 0.160427807486631 1.07794300783825 0.357405508653055 0.949358382359678 GO:0000217 DNA secondary structure binding 7/2774 39/18639 0.179487179487179 1.20600632244468 0.359242942674699 0.952255201476594 GO:0005516 calmodulin binding 33/2774 207/18639 0.159420289855072 1.07117331745086 0.362327121549501 0.957507010229222 GO:0015294 solute:monoatomic cation symporter activity 19/2774 116/18639 0.163793103448276 1.10055503070383 0.363049931357707 0.957507010229222 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 29/2774 181/18639 0.160220994475138 1.07655339438432 0.363477170941917 0.957507010229222 GO:0005525 GTP binding 59/2774 378/18639 0.156084656084656 1.04876060013046 0.366159656691528 0.961778251289015 GO:0071889 14-3-3 protein binding 6/2774 33/18639 0.181818181818182 1.22166874221669 0.366750306106919 0.961778251289015 GO:0180051 translation factor activity 14/2774 84/18639 0.166666666666667 1.11986301369863 0.367361575198236 0.961778251289015 GO:0004721 phosphoprotein phosphatase activity 28/2774 175/18639 0.16 1.07506849315069 0.369751996709232 0.966052860254654 GO:0004683 calcium/calmodulin-dependent protein kinase activity 5/2774 27/18639 0.185185185185185 1.24429223744292 0.374607599813467 0.968333374532021 GO:0023026 MHC class II protein complex binding 5/2774 27/18639 0.185185185185185 1.24429223744292 0.374607599813467 0.968333374532021 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 5/2774 27/18639 0.185185185185185 1.24429223744292 0.374607599813467 0.968333374532021 GO:0016798 hydrolase activity, acting on glycosyl bonds 21/2774 130/18639 0.161538461538462 1.08540569020021 0.377888563645072 0.968333374532021 GO:1990782 protein tyrosine kinase binding 19/2774 117/18639 0.162393162393162 1.09114857744995 0.377972053448551 0.968333374532021 GO:0019200 carbohydrate kinase activity 4/2774 21/18639 0.19047619047619 1.27984344422701 0.38271825098856 0.968333374532021 GO:0035613 RNA stem-loop binding 4/2774 21/18639 0.19047619047619 1.27984344422701 0.38271825098856 0.968333374532021 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 4/2774 21/18639 0.19047619047619 1.27984344422701 0.38271825098856 0.968333374532021 GO:0140312 cargo adaptor activity 4/2774 21/18639 0.19047619047619 1.27984344422701 0.38271825098856 0.968333374532021 GO:0015144 carbohydrate transmembrane transporter activity 7/2774 40/18639 0.175 1.17585616438356 0.385146744841485 0.968333374532021 GO:0032451 demethylase activity 7/2774 40/18639 0.175 1.17585616438356 0.385146744841485 0.968333374532021 GO:0005126 cytokine receptor binding 43/2774 275/18639 0.156363636363636 1.05063511830635 0.38732884543872 0.968333374532021 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 36/2774 229/18639 0.157205240174672 1.05629000418735 0.387930966255893 0.968333374532021 GO:0016860 intramolecular oxidoreductase activity 9/2774 53/18639 0.169811320754717 1.14099250452313 0.390129678028745 0.968333374532021 GO:1901505 carbohydrate derivative transmembrane transporter activity 9/2774 53/18639 0.169811320754717 1.14099250452313 0.390129678028745 0.968333374532021 GO:0004089 carbonate dehydratase activity 3/2774 15/18639 0.2 1.34383561643836 0.390661172254774 0.968333374532021 GO:0005402 carbohydrate:monoatomic cation symporter activity 3/2774 15/18639 0.2 1.34383561643836 0.390661172254774 0.968333374532021 GO:0008252 nucleotidase activity 3/2774 15/18639 0.2 1.34383561643836 0.390661172254774 0.968333374532021 GO:0015929 hexosaminidase activity 3/2774 15/18639 0.2 1.34383561643836 0.390661172254774 0.968333374532021 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 3/2774 15/18639 0.2 1.34383561643836 0.390661172254774 0.968333374532021 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 3/2774 15/18639 0.2 1.34383561643836 0.390661172254774 0.968333374532021 GO:0017081 chloride channel regulator activity 3/2774 15/18639 0.2 1.34383561643836 0.390661172254774 0.968333374532021 GO:0048531 beta-1,3-galactosyltransferase activity 3/2774 15/18639 0.2 1.34383561643836 0.390661172254774 0.968333374532021 GO:0051371 muscle alpha-actinin binding 3/2774 15/18639 0.2 1.34383561643836 0.390661172254774 0.968333374532021 GO:0061578 K63-linked deubiquitinase activity 3/2774 15/18639 0.2 1.34383561643836 0.390661172254774 0.968333374532021 GO:0019903 protein phosphatase binding 23/2774 144/18639 0.159722222222222 1.07320205479452 0.391093864923348 0.968333374532021 GO:0051020 GTPase binding 49/2774 315/18639 0.155555555555556 1.04520547945205 0.391543627305971 0.968333374532021 GO:0008235 metalloexopeptidase activity 11/2774 66/18639 0.166666666666667 1.11986301369863 0.392567997569278 0.968333374532021 GO:0019902 phosphatase binding 30/2774 190/18639 0.157894736842105 1.06092285508291 0.392649689908278 0.968333374532021 GO:0033293 monocarboxylic acid binding 13/2774 79/18639 0.164556962025316 1.10568753251257 0.393633143988626 0.968884669083973 GO:0061733 protein-lysine-acetyltransferase activity 8/2774 47/18639 0.170212765957447 1.14368988633052 0.400108706621001 0.979152784917037 GO:0061749 forked DNA-dependent helicase activity 8/2774 47/18639 0.170212765957447 1.14368988633052 0.400108706621001 0.979152784917037 GO:1990518 single-stranded 3'-5' DNA helicase activity 8/2774 47/18639 0.170212765957447 1.14368988633052 0.400108706621001 0.979152784917037 GO:0031267 small GTPase binding 44/2774 283/18639 0.15547703180212 1.04467786436904 0.401086370133842 0.979664984522315 GO:0016209 antioxidant activity 14/2774 86/18639 0.162790697674419 1.09381968779866 0.402701690101653 0.98172974164361 GO:0019789 SUMO transferase activity 5/2774 28/18639 0.178571428571429 1.19985322896282 0.406115143783587 0.986213239026435 GO:0141052 histone H3 demethylase activity 5/2774 28/18639 0.178571428571429 1.19985322896282 0.406115143783587 0.986213239026435 GO:0042578 phosphoric ester hydrolase activity 56/2774 363/18639 0.154269972451791 1.0365674176384 0.406861304884631 0.986213239026435 GO:0042287 MHC protein binding 7/2774 41/18639 0.170731707317073 1.14717674574006 0.411087987470251 0.987824564036546 GO:0048306 calcium-dependent protein binding 13/2774 80/18639 0.1625 1.09186643835616 0.4120963275505 0.987824564036546 GO:0015293 symporter activity 23/2774 146/18639 0.157534246575342 1.05850065678364 0.41840009223957 0.987824564036546 GO:0008649 rRNA methyltransferase activity 4/2774 22/18639 0.181818181818182 1.22166874221669 0.418623366933558 0.987824564036546 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 4/2774 22/18639 0.181818181818182 1.22166874221669 0.418623366933558 0.987824564036546 GO:0061133 endopeptidase activator activity 4/2774 22/18639 0.181818181818182 1.22166874221669 0.418623366933558 0.987824564036546 GO:0015399 primary active transmembrane transporter activity 26/2774 166/18639 0.156626506024096 1.05240138636739 0.421357424085269 0.987824564036546 GO:0019905 syntaxin binding 10/2774 61/18639 0.163934426229508 1.101504603638 0.423500510387617 0.987824564036546 GO:0009378 four-way junction helicase activity 8/2774 48/18639 0.166666666666667 1.11986301369863 0.424169458808843 0.987824564036546 GO:0032266 phosphatidylinositol-3-phosphate binding 8/2774 48/18639 0.166666666666667 1.11986301369863 0.424169458808843 0.987824564036546 GO:0036121 double-stranded DNA helicase activity 8/2774 48/18639 0.166666666666667 1.11986301369863 0.424169458808843 0.987824564036546 GO:0043138 3'-5' DNA helicase activity 8/2774 48/18639 0.166666666666667 1.11986301369863 0.424169458808843 0.987824564036546 GO:0016410 N-acyltransferase activity 15/2774 94/18639 0.159574468085106 1.07220926843486 0.42811616271223 0.987824564036546 GO:0019783 ubiquitin-like protein peptidase activity 20/2774 127/18639 0.15748031496063 1.05813828066012 0.42934508305057 0.987824564036546 GO:0000062 fatty-acyl-CoA binding 3/2774 16/18639 0.1875 1.25984589041096 0.433285658937303 0.987824564036546 GO:0004708 MAP kinase kinase activity 3/2774 16/18639 0.1875 1.25984589041096 0.433285658937303 0.987824564036546 GO:0005024 transforming growth factor beta receptor activity 3/2774 16/18639 0.1875 1.25984589041096 0.433285658937303 0.987824564036546 GO:0005159 insulin-like growth factor receptor binding 3/2774 16/18639 0.1875 1.25984589041096 0.433285658937303 0.987824564036546 GO:0005521 lamin binding 3/2774 16/18639 0.1875 1.25984589041096 0.433285658937303 0.987824564036546 GO:0022858 alanine transmembrane transporter activity 3/2774 16/18639 0.1875 1.25984589041096 0.433285658937303 0.987824564036546 GO:0030275 LRR domain binding 3/2774 16/18639 0.1875 1.25984589041096 0.433285658937303 0.987824564036546 GO:0097027 ubiquitin-protein transferase activator activity 3/2774 16/18639 0.1875 1.25984589041096 0.433285658937303 0.987824564036546 GO:0004402 histone acetyltransferase activity 7/2774 42/18639 0.166666666666667 1.11986301369863 0.436955144145001 0.987824564036546 GO:0016859 cis-trans isomerase activity 7/2774 42/18639 0.166666666666667 1.11986301369863 0.436955144145001 0.987824564036546 GO:0035250 UDP-galactosyltransferase activity 5/2774 29/18639 0.172413793103448 1.15847897968824 0.437404861164189 0.987824564036546 GO:0042393 histone binding 38/2774 247/18639 0.153846153846154 1.03371970495258 0.439113422014728 0.987824564036546 GO:0019001 guanyl nucleotide binding 61/2774 400/18639 0.1525 1.02467465753425 0.439127688747921 0.987824564036546 GO:0032561 guanyl ribonucleotide binding 61/2774 400/18639 0.1525 1.02467465753425 0.439127688747921 0.987824564036546 GO:0016763 pentosyltransferase activity 8/2774 49/18639 0.163265306122449 1.09700866648029 0.448147160269273 0.987824564036546 GO:0001094 TFIID-class transcription factor complex binding 2/2774 10/18639 0.2 1.34383561643836 0.451414547064414 0.987824564036546 GO:0004090 carbonyl reductase (NADPH) activity 2/2774 10/18639 0.2 1.34383561643836 0.451414547064414 0.987824564036546 GO:0004955 prostaglandin receptor activity 2/2774 10/18639 0.2 1.34383561643836 0.451414547064414 0.987824564036546 GO:0005528 FK506 binding 2/2774 10/18639 0.2 1.34383561643836 0.451414547064414 0.987824564036546 GO:0008140 cAMP response element binding protein binding 2/2774 10/18639 0.2 1.34383561643836 0.451414547064414 0.987824564036546 GO:0015279 store-operated calcium channel activity 2/2774 10/18639 0.2 1.34383561643836 0.451414547064414 0.987824564036546 GO:0016303 1-phosphatidylinositol-3-kinase activity 2/2774 10/18639 0.2 1.34383561643836 0.451414547064414 0.987824564036546 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 2/2774 10/18639 0.2 1.34383561643836 0.451414547064414 0.987824564036546 GO:0019531 oxalate transmembrane transporter activity 2/2774 10/18639 0.2 1.34383561643836 0.451414547064414 0.987824564036546 GO:0030957 Tat protein binding 2/2774 10/18639 0.2 1.34383561643836 0.451414547064414 0.987824564036546 GO:0032052 bile acid binding 2/2774 10/18639 0.2 1.34383561643836 0.451414547064414 0.987824564036546 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 2/2774 10/18639 0.2 1.34383561643836 0.451414547064414 0.987824564036546 GO:0035256 G protein-coupled glutamate receptor binding 2/2774 10/18639 0.2 1.34383561643836 0.451414547064414 0.987824564036546 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 2/2774 10/18639 0.2 1.34383561643836 0.451414547064414 0.987824564036546 GO:0043121 neurotrophin binding 2/2774 10/18639 0.2 1.34383561643836 0.451414547064414 0.987824564036546 GO:0051880 G-quadruplex DNA binding 2/2774 10/18639 0.2 1.34383561643836 0.451414547064414 0.987824564036546 GO:0070739 protein-glutamic acid ligase activity 2/2774 10/18639 0.2 1.34383561643836 0.451414547064414 0.987824564036546 GO:0070740 tubulin-glutamic acid ligase activity 2/2774 10/18639 0.2 1.34383561643836 0.451414547064414 0.987824564036546 GO:0071723 lipopeptide binding 2/2774 10/18639 0.2 1.34383561643836 0.451414547064414 0.987824564036546 GO:0098505 G-rich strand telomeric DNA binding 2/2774 10/18639 0.2 1.34383561643836 0.451414547064414 0.987824564036546 GO:0140940 histone H2A methyltransferase activity 2/2774 10/18639 0.2 1.34383561643836 0.451414547064414 0.987824564036546 GO:0141109 transporter activator activity 2/2774 10/18639 0.2 1.34383561643836 0.451414547064414 0.987824564036546 GO:1990259 histone H2AQ104 methyltransferase activity 2/2774 10/18639 0.2 1.34383561643836 0.451414547064414 0.987824564036546 GO:0000993 RNA polymerase II complex binding 6/2774 36/18639 0.166666666666667 1.11986301369863 0.451447215981896 0.987824564036546 GO:0044390 ubiquitin-like protein conjugating enzyme binding 6/2774 36/18639 0.166666666666667 1.11986301369863 0.451447215981896 0.987824564036546 GO:0008080 N-acetyltransferase activity 11/2774 69/18639 0.159420289855072 1.07117331745086 0.453169951760452 0.987824564036546 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 4/2774 23/18639 0.173913043478261 1.1685527099464 0.454011917274836 0.987824564036546 GO:0004022 alcohol dehydrogenase (NAD+) activity 4/2774 23/18639 0.173913043478261 1.1685527099464 0.454011917274836 0.987824564036546 GO:0016493 C-C chemokine receptor activity 4/2774 23/18639 0.173913043478261 1.1685527099464 0.454011917274836 0.987824564036546 GO:0140102 catalytic activity, acting on a rRNA 4/2774 23/18639 0.173913043478261 1.1685527099464 0.454011917274836 0.987824564036546 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 4/2774 23/18639 0.173913043478261 1.1685527099464 0.454011917274836 0.987824564036546 GO:0008509 monoatomic anion transmembrane transporter activity 23/2774 149/18639 0.154362416107383 1.03718856302289 0.459550880156424 0.998172695399388 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 7/2774 43/18639 0.162790697674419 1.09381968779866 0.462643334275391 1 GO:0140375 immune receptor activity 24/2774 156/18639 0.153846153846154 1.03371970495258 0.464196393414317 1 GO:0001965 G-protein alpha-subunit binding 5/2774 30/18639 0.166666666666667 1.11986301369863 0.468300405447387 1 GO:0015215 nucleotide transmembrane transporter activity 5/2774 30/18639 0.166666666666667 1.11986301369863 0.468300405447387 1 GO:0031624 ubiquitin conjugating enzyme binding 5/2774 30/18639 0.166666666666667 1.11986301369863 0.468300405447387 1 GO:0032452 histone demethylase activity 5/2774 30/18639 0.166666666666667 1.11986301369863 0.468300405447387 1 GO:0051721 protein phosphatase 2A binding 5/2774 30/18639 0.166666666666667 1.11986301369863 0.468300405447387 1 GO:0000287 magnesium ion binding 35/2774 230/18639 0.152173913043478 1.0224836212031 0.471486594053599 1 GO:0004029 aldehyde dehydrogenase (NAD+) activity 3/2774 17/18639 0.176470588235294 1.18573730862208 0.474751027438094 1 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 3/2774 17/18639 0.176470588235294 1.18573730862208 0.474751027438094 1 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 3/2774 17/18639 0.176470588235294 1.18573730862208 0.474751027438094 1 GO:0015278 intracellularly gated calcium channel activity 3/2774 17/18639 0.176470588235294 1.18573730862208 0.474751027438094 1 GO:0017110 nucleoside diphosphate phosphatase activity 3/2774 17/18639 0.176470588235294 1.18573730862208 0.474751027438094 1 GO:0032977 membrane insertase activity 3/2774 17/18639 0.176470588235294 1.18573730862208 0.474751027438094 1 GO:1901567 fatty acid derivative binding 3/2774 17/18639 0.176470588235294 1.18573730862208 0.474751027438094 1 GO:0019787 ubiquitin-like protein transferase activity 72/2774 479/18639 0.150313152400835 1.00998083907684 0.483266310503981 1 GO:0061659 ubiquitin-like protein ligase activity 56/2774 372/18639 0.150537634408602 1.01148917366328 0.485407494347721 1 GO:0004622 lysophospholipase activity 4/2774 24/18639 0.166666666666667 1.11986301369863 0.488653194349078 1 GO:0004806 triacylglycerol lipase activity 4/2774 24/18639 0.166666666666667 1.11986301369863 0.488653194349078 1 GO:0015149 hexose transmembrane transporter activity 4/2774 24/18639 0.166666666666667 1.11986301369863 0.488653194349078 1 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 4/2774 24/18639 0.166666666666667 1.11986301369863 0.488653194349078 1 GO:0019957 C-C chemokine binding 4/2774 24/18639 0.166666666666667 1.11986301369863 0.488653194349078 1 GO:0048027 mRNA 5'-UTR binding 4/2774 24/18639 0.166666666666667 1.11986301369863 0.488653194349078 1 GO:0055056 D-glucose transmembrane transporter activity 4/2774 24/18639 0.166666666666667 1.11986301369863 0.488653194349078 1 GO:0070300 phosphatidic acid binding 4/2774 24/18639 0.166666666666667 1.11986301369863 0.488653194349078 1 GO:0070840 dynein complex binding 4/2774 24/18639 0.166666666666667 1.11986301369863 0.488653194349078 1 GO:0140299 molecular sensor activity 11/2774 71/18639 0.154929577464789 1.04099942118464 0.493203079226473 1 GO:0061630 ubiquitin protein ligase activity 53/2774 353/18639 0.15014164305949 1.00882843726959 0.495377563622821 1 GO:0005310 dicarboxylic acid transmembrane transporter activity 5/2774 31/18639 0.161290322580645 1.08373840035351 0.498644619875012 1 GO:0008327 methyl-CpG binding 5/2774 31/18639 0.161290322580645 1.08373840035351 0.498644619875012 1 GO:0000099 sulfur amino acid transmembrane transporter activity 2/2774 11/18639 0.181818181818182 1.22166874221669 0.503373982876971 1 GO:0004143 ATP-dependent diacylglycerol kinase activity 2/2774 11/18639 0.181818181818182 1.22166874221669 0.503373982876971 1 GO:0004954 prostanoid receptor activity 2/2774 11/18639 0.181818181818182 1.22166874221669 0.503373982876971 1 GO:0005114 type II transforming growth factor beta receptor binding 2/2774 11/18639 0.181818181818182 1.22166874221669 0.503373982876971 1 GO:0008271 secondary active sulfate transmembrane transporter activity 2/2774 11/18639 0.181818181818182 1.22166874221669 0.503373982876971 1 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 2/2774 11/18639 0.181818181818182 1.22166874221669 0.503373982876971 1 GO:0016176 superoxide-generating NADPH oxidase activator activity 2/2774 11/18639 0.181818181818182 1.22166874221669 0.503373982876971 1 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 2/2774 11/18639 0.181818181818182 1.22166874221669 0.503373982876971 1 GO:0031731 CCR6 chemokine receptor binding 2/2774 11/18639 0.181818181818182 1.22166874221669 0.503373982876971 1 GO:0032050 clathrin heavy chain binding 2/2774 11/18639 0.181818181818182 1.22166874221669 0.503373982876971 1 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 2/2774 11/18639 0.181818181818182 1.22166874221669 0.503373982876971 1 GO:0047676 arachidonate-CoA ligase activity 2/2774 11/18639 0.181818181818182 1.22166874221669 0.503373982876971 1 GO:0050786 RAGE receptor binding 2/2774 11/18639 0.181818181818182 1.22166874221669 0.503373982876971 1 GO:0070990 snRNP binding 2/2774 11/18639 0.181818181818182 1.22166874221669 0.503373982876971 1 GO:0099528 G protein-coupled neurotransmitter receptor activity 2/2774 11/18639 0.181818181818182 1.22166874221669 0.503373982876971 1 GO:0140537 transcription regulator activator activity 2/2774 11/18639 0.181818181818182 1.22166874221669 0.503373982876971 1 GO:0004842 ubiquitin-protein transferase activity 67/2774 449/18639 0.149220489977728 1.00263904567227 0.511354372753271 1 GO:0000400 four-way junction DNA binding 3/2774 18/18639 0.166666666666667 1.11986301369863 0.514752274900961 1 GO:0003746 translation elongation factor activity 3/2774 18/18639 0.166666666666667 1.11986301369863 0.514752274900961 1 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 3/2774 18/18639 0.166666666666667 1.11986301369863 0.514752274900961 1 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 3/2774 18/18639 0.166666666666667 1.11986301369863 0.514752274900961 1 GO:0004706 JUN kinase kinase kinase activity 3/2774 18/18639 0.166666666666667 1.11986301369863 0.514752274900961 1 GO:0008308 voltage-gated monoatomic anion channel activity 3/2774 18/18639 0.166666666666667 1.11986301369863 0.514752274900961 1 GO:0015280 ligand-gated sodium channel activity 3/2774 18/18639 0.166666666666667 1.11986301369863 0.514752274900961 1 GO:0017075 syntaxin-1 binding 3/2774 18/18639 0.166666666666667 1.11986301369863 0.514752274900961 1 GO:0032393 MHC class I receptor activity 3/2774 18/18639 0.166666666666667 1.11986301369863 0.514752274900961 1 GO:0034185 apolipoprotein binding 3/2774 18/18639 0.166666666666667 1.11986301369863 0.514752274900961 1 GO:0035615 clathrin adaptor activity 3/2774 18/18639 0.166666666666667 1.11986301369863 0.514752274900961 1 GO:0050811 GABA receptor binding 3/2774 18/18639 0.166666666666667 1.11986301369863 0.514752274900961 1 GO:0070628 proteasome binding 3/2774 18/18639 0.166666666666667 1.11986301369863 0.514752274900961 1 GO:1901611 phosphatidylglycerol binding 3/2774 18/18639 0.166666666666667 1.11986301369863 0.514752274900961 1 GO:1990381 ubiquitin-specific protease binding 3/2774 18/18639 0.166666666666667 1.11986301369863 0.514752274900961 1 GO:0008013 beta-catenin binding 16/2774 106/18639 0.150943396226415 1.01421555957612 0.517372343830362 1 GO:0031406 carboxylic acid binding 28/2774 187/18639 0.149732620320856 1.00608014064904 0.51776441382645 1 GO:0015296 monoatomic anion:monoatomic cation symporter activity 4/2774 25/18639 0.16 1.07506849315069 0.522352041530159 1 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 4/2774 25/18639 0.16 1.07506849315069 0.522352041530159 1 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 4/2774 25/18639 0.16 1.07506849315069 0.522352041530159 1 GO:0008378 galactosyltransferase activity 5/2774 32/18639 0.15625 1.04987157534247 0.528299890371759 1 GO:0071813 lipoprotein particle binding 5/2774 32/18639 0.15625 1.04987157534247 0.528299890371759 1 GO:0071814 protein-lipid complex binding 5/2774 32/18639 0.15625 1.04987157534247 0.528299890371759 1 GO:0140142 nucleocytoplasmic carrier activity 5/2774 32/18639 0.15625 1.04987157534247 0.528299890371759 1 GO:0043130 ubiquitin binding 15/2774 100/18639 0.15 1.00787671232877 0.52992511965673 1 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 6/2774 39/18639 0.153846153846154 1.03371970495258 0.533307509257868 1 GO:0019888 protein phosphatase regulator activity 16/2774 107/18639 0.149532710280374 1.00473690948662 0.533501058617038 1 GO:0005544 calcium-dependent phospholipid binding 8/2774 53/18639 0.150943396226415 1.01421555957612 0.541650784194809 1 GO:0034212 protein N-acetyltransferase activity 8/2774 53/18639 0.150943396226415 1.01421555957612 0.541650784194809 1 GO:0043177 organic acid binding 28/2774 189/18639 0.148148148148148 0.995433789954338 0.542082518539141 1 GO:0001098 basal transcription machinery binding 9/2774 60/18639 0.15 1.00787671232877 0.545269266966063 1 GO:0001099 basal RNA polymerase II transcription machinery binding 9/2774 60/18639 0.15 1.00787671232877 0.545269266966063 1 GO:0000995 RNA polymerase III general transcription initiation factor activity 2/2774 12/18639 0.166666666666667 1.11986301369863 0.552024170533632 1 GO:0004126 cytidine deaminase activity 2/2774 12/18639 0.166666666666667 1.11986301369863 0.552024170533632 1 GO:0004300 enoyl-CoA hydratase activity 2/2774 12/18639 0.166666666666667 1.11986301369863 0.552024170533632 1 GO:0005049 nuclear export signal receptor activity 2/2774 12/18639 0.166666666666667 1.11986301369863 0.552024170533632 1 GO:0005095 GTPase inhibitor activity 2/2774 12/18639 0.166666666666667 1.11986301369863 0.552024170533632 1 GO:0005165 neurotrophin receptor binding 2/2774 12/18639 0.166666666666667 1.11986301369863 0.552024170533632 1 GO:0005436 sodium:phosphate symporter activity 2/2774 12/18639 0.166666666666667 1.11986301369863 0.552024170533632 1 GO:0005527 macrolide binding 2/2774 12/18639 0.166666666666667 1.11986301369863 0.552024170533632 1 GO:0015166 polyol transmembrane transporter activity 2/2774 12/18639 0.166666666666667 1.11986301369863 0.552024170533632 1 GO:0015269 calcium-activated potassium channel activity 2/2774 12/18639 0.166666666666667 1.11986301369863 0.552024170533632 1 GO:0017166 vinculin binding 2/2774 12/18639 0.166666666666667 1.11986301369863 0.552024170533632 1 GO:0035497 cAMP response element binding 2/2774 12/18639 0.166666666666667 1.11986301369863 0.552024170533632 1 GO:0036009 protein-glutamine N-methyltransferase activity 2/2774 12/18639 0.166666666666667 1.11986301369863 0.552024170533632 1 GO:0045295 gamma-catenin binding 2/2774 12/18639 0.166666666666667 1.11986301369863 0.552024170533632 1 GO:0070679 inositol 1,4,5 trisphosphate binding 2/2774 12/18639 0.166666666666667 1.11986301369863 0.552024170533632 1 GO:0140829 bicarbonate:monoatomic anion antiporter activity 2/2774 12/18639 0.166666666666667 1.11986301369863 0.552024170533632 1 GO:0140900 chloride:bicarbonate antiporter activity 2/2774 12/18639 0.166666666666667 1.11986301369863 0.552024170533632 1 GO:0017124 SH3 domain binding 17/2774 115/18639 0.147826086956522 0.993269803454437 0.552341002684818 1 GO:0008381 mechanosensitive monoatomic ion channel activity 3/2774 19/18639 0.157894736842105 1.06092285508291 0.553056997731219 1 GO:0031420 alkali metal ion binding 3/2774 19/18639 0.157894736842105 1.06092285508291 0.553056997731219 1 GO:0042577 lipid phosphatase activity 3/2774 19/18639 0.157894736842105 1.06092285508291 0.553056997731219 1 GO:0046624 sphingolipid transporter activity 3/2774 19/18639 0.157894736842105 1.06092285508291 0.553056997731219 1 GO:0120227 acyl-CoA binding 3/2774 19/18639 0.157894736842105 1.06092285508291 0.553056997731219 1 GO:0030971 receptor tyrosine kinase binding 12/2774 81/18639 0.148148148148148 0.995433789954338 0.554729207611149 1 GO:0001637 G protein-coupled chemoattractant receptor activity 4/2774 26/18639 0.153846153846154 1.03371970495258 0.55494753018588 1 GO:0004950 chemokine receptor activity 4/2774 26/18639 0.153846153846154 1.03371970495258 0.55494753018588 1 GO:0005112 Notch binding 4/2774 26/18639 0.153846153846154 1.03371970495258 0.55494753018588 1 GO:0005227 calcium-activated cation channel activity 4/2774 26/18639 0.153846153846154 1.03371970495258 0.55494753018588 1 GO:0008198 ferrous iron binding 4/2774 26/18639 0.153846153846154 1.03371970495258 0.55494753018588 1 GO:0015145 monosaccharide transmembrane transporter activity 4/2774 26/18639 0.153846153846154 1.03371970495258 0.55494753018588 1 GO:0030507 spectrin binding 4/2774 26/18639 0.153846153846154 1.03371970495258 0.55494753018588 1 GO:0050750 low-density lipoprotein particle receptor binding 4/2774 26/18639 0.153846153846154 1.03371970495258 0.55494753018588 1 GO:0052742 phosphatidylinositol kinase activity 4/2774 26/18639 0.153846153846154 1.03371970495258 0.55494753018588 1 GO:0070006 metalloaminopeptidase activity 4/2774 26/18639 0.153846153846154 1.03371970495258 0.55494753018588 1 GO:0019239 deaminase activity 5/2774 33/18639 0.151515151515152 1.01805728518057 0.557148030419052 1 GO:0004177 aminopeptidase activity 6/2774 40/18639 0.15 1.00787671232877 0.559453526507818 1 GO:0061791 GTPase motor activity 6/2774 40/18639 0.15 1.00787671232877 0.559453526507818 1 GO:1990606 membrane scission GTPase motor activity 6/2774 40/18639 0.15 1.00787671232877 0.559453526507818 1 GO:0044325 transmembrane transporter binding 20/2774 136/18639 0.147058823529412 0.988114423851732 0.560265542833341 1 GO:0016755 aminoacyltransferase activity 73/2774 496/18639 0.147177419354839 0.988911290322581 0.561488998996542 1 GO:0005504 fatty acid binding 7/2774 47/18639 0.148936170212766 1.0007286505392 0.561777483157455 1 GO:0008238 exopeptidase activity 15/2774 102/18639 0.147058823529412 0.988114423851732 0.562785960088815 1 GO:0004620 phospholipase activity 16/2774 109/18639 0.146788990825688 0.986301369863014 0.565250106231169 1 GO:0016298 lipase activity 19/2774 130/18639 0.146153846153846 0.982033719704953 0.572134830090652 1 GO:0019208 phosphatase regulator activity 17/2774 117/18639 0.145299145299145 0.976290832455216 0.582713195081577 1 GO:0015175 neutral L-amino acid transmembrane transporter activity 6/2774 41/18639 0.146341463414634 0.98329435349148 0.584887618914258 1 GO:0008376 acetylgalactosaminyltransferase activity 5/2774 34/18639 0.147058823529412 0.988114423851732 0.58508978409817 1 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 5/2774 34/18639 0.147058823529412 0.988114423851732 0.58508978409817 1 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 5/2774 34/18639 0.147058823529412 0.988114423851732 0.58508978409817 1 GO:0019825 oxygen binding 5/2774 34/18639 0.147058823529412 0.988114423851732 0.58508978409817 1 GO:0030332 cyclin binding 5/2774 34/18639 0.147058823529412 0.988114423851732 0.58508978409817 1 GO:0008374 O-acyltransferase activity 8/2774 55/18639 0.145454545454545 0.97733499377335 0.586015634707944 1 GO:0061608 nuclear import signal receptor activity 3/2774 20/18639 0.15 1.00787671232877 0.589497066887087 1 GO:0003964 RNA-directed DNA polymerase activity 2/2774 13/18639 0.153846153846154 1.03371970495258 0.597198988630316 1 GO:0004465 lipoprotein lipase activity 2/2774 13/18639 0.153846153846154 1.03371970495258 0.597198988630316 1 GO:0005172 vascular endothelial growth factor receptor binding 2/2774 13/18639 0.153846153846154 1.03371970495258 0.597198988630316 1 GO:0005542 folic acid binding 2/2774 13/18639 0.153846153846154 1.03371970495258 0.597198988630316 1 GO:0009982 pseudouridine synthase activity 2/2774 13/18639 0.153846153846154 1.03371970495258 0.597198988630316 1 GO:0030955 potassium ion binding 2/2774 13/18639 0.153846153846154 1.03371970495258 0.597198988630316 1 GO:0031432 titin binding 2/2774 13/18639 0.153846153846154 1.03371970495258 0.597198988630316 1 GO:0035673 oligopeptide transmembrane transporter activity 2/2774 13/18639 0.153846153846154 1.03371970495258 0.597198988630316 1 GO:0045159 myosin II binding 2/2774 13/18639 0.153846153846154 1.03371970495258 0.597198988630316 1 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 2/2774 13/18639 0.153846153846154 1.03371970495258 0.597198988630316 1 GO:0061459 L-arginine transmembrane transporter activity 2/2774 13/18639 0.153846153846154 1.03371970495258 0.597198988630316 1 GO:0071837 HMG box domain binding 2/2774 13/18639 0.153846153846154 1.03371970495258 0.597198988630316 1 GO:0140333 glycerophospholipid flippase activity 2/2774 13/18639 0.153846153846154 1.03371970495258 0.597198988630316 1 GO:0140852 histone ubiquitin ligase activity 2/2774 13/18639 0.153846153846154 1.03371970495258 0.597198988630316 1 GO:0140767 enzyme-substrate adaptor activity 20/2774 139/18639 0.143884892086331 0.966788213265004 0.60181748294926 1 GO:1901682 sulfur compound transmembrane transporter activity 9/2774 63/18639 0.142857142857143 0.959882583170254 0.607167882455274 1 GO:0016782 transferase activity, transferring sulphur-containing groups 10/2774 70/18639 0.142857142857143 0.959882583170254 0.607263110429267 1 GO:0003724 RNA helicase activity 11/2774 77/18639 0.142857142857143 0.959882583170254 0.607602248835509 1 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 13/2774 91/18639 0.142857142857143 0.959882583170254 0.608779122719944 1 GO:0051119 sugar transmembrane transporter activity 4/2774 28/18639 0.142857142857143 0.959882583170254 0.61634363842994 1 GO:0051393 alpha-actinin binding 4/2774 28/18639 0.142857142857143 0.959882583170254 0.61634363842994 1 GO:0009931 calcium-dependent protein serine/threonine kinase activity 3/2774 21/18639 0.142857142857143 0.959882583170254 0.623960202870175 1 GO:1904047 S-adenosyl-L-methionine binding 3/2774 21/18639 0.142857142857143 0.959882583170254 0.623960202870175 1 GO:0043178 alcohol binding 13/2774 92/18639 0.141304347826087 0.949449076831447 0.625232600180564 1 GO:0004857 enzyme inhibitor activity 60/2774 416/18639 0.144230769230769 0.969112223393045 0.62631138553178 1 GO:0032182 ubiquitin-like protein binding 17/2774 120/18639 0.141666666666667 0.951883561643836 0.62664638112011 1 GO:0042826 histone deacetylase binding 18/2774 127/18639 0.141732283464567 0.952324452594111 0.627232472634461 1 GO:0048020 CCR chemokine receptor binding 7/2774 50/18639 0.14 0.940684931506849 0.630292269764388 1 GO:0016791 phosphatase activity 39/2774 273/18639 0.142857142857143 0.959882583170254 0.635981062576759 1 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 5/2774 36/18639 0.138888888888889 0.933219178082192 0.637946738677718 1 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 5/2774 36/18639 0.138888888888889 0.933219178082192 0.637946738677718 1 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 5/2774 36/18639 0.138888888888889 0.933219178082192 0.637946738677718 1 GO:0005161 platelet-derived growth factor receptor binding 2/2774 14/18639 0.142857142857143 0.959882583170254 0.638855008706924 1 GO:0005313 L-glutamate transmembrane transporter activity 2/2774 14/18639 0.142857142857143 0.959882583170254 0.638855008706924 1 GO:0005344 oxygen carrier activity 2/2774 14/18639 0.142857142857143 0.959882583170254 0.638855008706924 1 GO:0008174 mRNA methyltransferase activity 2/2774 14/18639 0.142857142857143 0.959882583170254 0.638855008706924 1 GO:0008195 phosphatidate phosphatase activity 2/2774 14/18639 0.142857142857143 0.959882583170254 0.638855008706924 1 GO:0015926 glucosidase activity 2/2774 14/18639 0.142857142857143 0.959882583170254 0.638855008706924 1 GO:0019763 immunoglobulin receptor activity 2/2774 14/18639 0.142857142857143 0.959882583170254 0.638855008706924 1 GO:0031404 chloride ion binding 2/2774 14/18639 0.142857142857143 0.959882583170254 0.638855008706924 1 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 2/2774 14/18639 0.142857142857143 0.959882583170254 0.638855008706924 1 GO:0043176 amine binding 2/2774 14/18639 0.142857142857143 0.959882583170254 0.638855008706924 1 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 2/2774 14/18639 0.142857142857143 0.959882583170254 0.638855008706924 1 GO:0061665 SUMO ligase activity 2/2774 14/18639 0.142857142857143 0.959882583170254 0.638855008706924 1 GO:0071933 Arp2/3 complex binding 2/2774 14/18639 0.142857142857143 0.959882583170254 0.638855008706924 1 GO:0008186 ATP-dependent activity, acting on RNA 11/2774 79/18639 0.139240506329114 0.935581758279868 0.642887078863018 1 GO:0042379 chemokine receptor binding 10/2774 72/18639 0.138888888888889 0.933219178082192 0.644186672043335 1 GO:0003785 actin monomer binding 4/2774 29/18639 0.137931034482759 0.92678318375059 0.64497384279246 1 GO:0043236 laminin binding 4/2774 29/18639 0.137931034482759 0.92678318375059 0.64497384279246 1 GO:0120013 lipid transfer activity 9/2774 65/18639 0.138461538461538 0.930347734457323 0.645974647224895 1 GO:0003743 translation initiation factor activity 7/2774 51/18639 0.137254901960784 0.922240128928284 0.651732189576703 1 GO:0101005 deubiquitinase activity 16/2774 115/18639 0.139130434782609 0.934842167957117 0.654987410885405 1 GO:0005496 steroid binding 15/2774 108/18639 0.138888888888889 0.933219178082192 0.655470886659727 1 GO:0001046 core promoter sequence-specific DNA binding 6/2774 44/18639 0.136363636363636 0.916251556662515 0.656308215877294 1 GO:0030020 extracellular matrix structural constituent conferring tensile strength 6/2774 44/18639 0.136363636363636 0.916251556662515 0.656308215877294 1 GO:0043014 alpha-tubulin binding 6/2774 44/18639 0.136363636363636 0.916251556662515 0.656308215877294 1 GO:0015377 chloride:monoatomic cation symporter activity 3/2774 22/18639 0.136363636363636 0.916251556662515 0.656381808544378 1 GO:0033691 sialic acid binding 3/2774 22/18639 0.136363636363636 0.916251556662515 0.656381808544378 1 GO:0050321 tau-protein kinase activity 3/2774 22/18639 0.136363636363636 0.916251556662515 0.656381808544378 1 GO:0140517 protein-RNA adaptor activity 3/2774 22/18639 0.136363636363636 0.916251556662515 0.656381808544378 1 GO:0003924 GTPase activity 47/2774 331/18639 0.141993957703928 0.954082688407896 0.661229783305596 1 GO:0042805 actinin binding 5/2774 37/18639 0.135135135135135 0.907997038134024 0.662749806751127 1 GO:0043394 proteoglycan binding 5/2774 37/18639 0.135135135135135 0.907997038134024 0.662749806751127 1 GO:0019955 cytokine binding 20/2774 144/18639 0.138888888888889 0.933219178082192 0.667068428088082 1 GO:0008106 alcohol dehydrogenase (NADP+) activity 4/2774 30/18639 0.133333333333333 0.895890410958904 0.672154371614779 1 GO:0022839 monoatomic ion-gated channel activity 4/2774 30/18639 0.133333333333333 0.895890410958904 0.672154371614779 1 GO:0031210 phosphatidylcholine binding 4/2774 30/18639 0.133333333333333 0.895890410958904 0.672154371614779 1 GO:0070566 adenylyltransferase activity 4/2774 30/18639 0.133333333333333 0.895890410958904 0.672154371614779 1 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 7/2774 52/18639 0.134615384615385 0.904504741833509 0.672413692026171 1 GO:0033192 calmodulin-dependent protein phosphatase activity 11/2774 81/18639 0.135802469135802 0.91248097412481 0.676395848501296 1 GO:0140791 histone H2AXS140 phosphatase activity 11/2774 81/18639 0.135802469135802 0.91248097412481 0.676395848501296 1 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 11/2774 81/18639 0.135802469135802 0.91248097412481 0.676395848501296 1 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 11/2774 81/18639 0.135802469135802 0.91248097412481 0.676395848501296 1 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 11/2774 81/18639 0.135802469135802 0.91248097412481 0.676395848501296 1 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 11/2774 81/18639 0.135802469135802 0.91248097412481 0.676395848501296 1 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 11/2774 81/18639 0.135802469135802 0.91248097412481 0.676395848501296 1 GO:1990439 MAP kinase serine/threonine phosphatase activity 11/2774 81/18639 0.135802469135802 0.91248097412481 0.676395848501296 1 GO:0004467 long-chain fatty acid-CoA ligase activity 2/2774 15/18639 0.133333333333333 0.895890410958904 0.677038675853409 1 GO:0004865 protein serine/threonine phosphatase inhibitor activity 2/2774 15/18639 0.133333333333333 0.895890410958904 0.677038675853409 1 GO:0004953 icosanoid receptor activity 2/2774 15/18639 0.133333333333333 0.895890410958904 0.677038675853409 1 GO:0005523 tropomyosin binding 2/2774 15/18639 0.133333333333333 0.895890410958904 0.677038675853409 1 GO:0008242 omega peptidase activity 2/2774 15/18639 0.133333333333333 0.895890410958904 0.677038675853409 1 GO:0015116 sulfate transmembrane transporter activity 2/2774 15/18639 0.133333333333333 0.895890410958904 0.677038675853409 1 GO:0015556 C4-dicarboxylate transmembrane transporter activity 2/2774 15/18639 0.133333333333333 0.895890410958904 0.677038675853409 1 GO:0042809 nuclear vitamin D receptor binding 2/2774 15/18639 0.133333333333333 0.895890410958904 0.677038675853409 1 GO:0047372 monoacylglycerol lipase activity 2/2774 15/18639 0.133333333333333 0.895890410958904 0.677038675853409 1 GO:0001217 DNA-binding transcription repressor activity 39/2774 278/18639 0.140287769784173 0.942618507933379 0.681899728919957 1 GO:0004722 protein serine/threonine phosphatase activity 14/2774 103/18639 0.135922330097087 0.913286341268786 0.685495585460556 1 GO:0005253 monoatomic anion channel activity 14/2774 103/18639 0.135922330097087 0.913286341268786 0.685495585460556 1 GO:0017134 fibroblast growth factor binding 3/2774 23/18639 0.130434782608696 0.876414532459797 0.686737292234809 1 GO:0042171 lysophosphatidic acid acyltransferase activity 3/2774 23/18639 0.130434782608696 0.876414532459797 0.686737292234809 1 GO:0071617 lysophospholipid acyltransferase activity 3/2774 23/18639 0.130434782608696 0.876414532459797 0.686737292234809 1 GO:0038064 collagen receptor activity 7/2774 53/18639 0.132075471698113 0.887438614629103 0.692312395391814 1 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 11/2774 82/18639 0.134146341463415 0.90135315736719 0.692439171013177 1 GO:0033549 MAP kinase phosphatase activity 11/2774 82/18639 0.134146341463415 0.90135315736719 0.692439171013177 1 GO:0005452 solute:inorganic anion antiporter activity 4/2774 31/18639 0.129032258064516 0.86699072028281 0.69785952002067 1 GO:0016411 acylglycerol O-acyltransferase activity 4/2774 31/18639 0.129032258064516 0.86699072028281 0.69785952002067 1 GO:0016878 acid-thiol ligase activity 4/2774 31/18639 0.129032258064516 0.86699072028281 0.69785952002067 1 GO:0070325 lipoprotein particle receptor binding 4/2774 31/18639 0.129032258064516 0.86699072028281 0.69785952002067 1 GO:0072349 modified amino acid transmembrane transporter activity 4/2774 31/18639 0.129032258064516 0.86699072028281 0.69785952002067 1 GO:0005548 phospholipid transporter activity 9/2774 68/18639 0.132352941176471 0.889302981466559 0.699920948037334 1 GO:0005506 iron ion binding 21/2774 154/18639 0.136363636363636 0.916251556662515 0.702400500939439 1 GO:0015026 coreceptor activity 8/2774 61/18639 0.131147540983607 0.881203682910398 0.705017368986614 1 GO:0001540 amyloid-beta binding 11/2774 83/18639 0.132530120481928 0.890493480772405 0.707990232406389 1 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 11/2774 83/18639 0.132530120481928 0.890493480772405 0.707990232406389 1 GO:0015485 cholesterol binding 7/2774 54/18639 0.12962962962963 0.871004566210046 0.711410746922338 1 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 7/2774 54/18639 0.12962962962963 0.871004566210046 0.711410746922338 1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 2/2774 16/18639 0.125 0.839897260273973 0.711860535412853 1 GO:0008142 oxysterol binding 2/2774 16/18639 0.125 0.839897260273973 0.711860535412853 1 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 2/2774 16/18639 0.125 0.839897260273973 0.711860535412853 1 GO:0034450 ubiquitin-ubiquitin ligase activity 2/2774 16/18639 0.125 0.839897260273973 0.711860535412853 1 GO:0043023 ribosomal large subunit binding 2/2774 16/18639 0.125 0.839897260273973 0.711860535412853 1 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 2/2774 16/18639 0.125 0.839897260273973 0.711860535412853 1 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 2/2774 16/18639 0.125 0.839897260273973 0.711860535412853 1 GO:0070411 I-SMAD binding 2/2774 16/18639 0.125 0.839897260273973 0.711860535412853 1 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 2/2774 16/18639 0.125 0.839897260273973 0.711860535412853 1 GO:0140327 flippase activity 2/2774 16/18639 0.125 0.839897260273973 0.711860535412853 1 GO:0001091 RNA polymerase II general transcription initiation factor binding 3/2774 24/18639 0.125 0.839897260273973 0.715035020504199 1 GO:0005540 hyaluronic acid binding 3/2774 24/18639 0.125 0.839897260273973 0.715035020504199 1 GO:0042625 ATPase-coupled ion transmembrane transporter activity 3/2774 24/18639 0.125 0.839897260273973 0.715035020504199 1 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 3/2774 24/18639 0.125 0.839897260273973 0.715035020504199 1 GO:0046961 proton-transporting ATPase activity, rotational mechanism 3/2774 24/18639 0.125 0.839897260273973 0.715035020504199 1 GO:0050699 WW domain binding 3/2774 24/18639 0.125 0.839897260273973 0.715035020504199 1 GO:0060229 lipase activator activity 3/2774 24/18639 0.125 0.839897260273973 0.715035020504199 1 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 37/2774 268/18639 0.138059701492537 0.927647720302597 0.716394643311082 1 GO:0140359 ABC-type transporter activity 6/2774 47/18639 0.127659574468085 0.857767414747887 0.719581468784356 1 GO:0031369 translation initiation factor binding 4/2774 32/18639 0.125 0.839897260273973 0.722082324256229 1 GO:0015179 L-amino acid transmembrane transporter activity 8/2774 62/18639 0.129032258064516 0.86699072028281 0.722502752891141 1 GO:0022804 active transmembrane transporter activity 64/2774 457/18639 0.140043763676149 0.940978987440425 0.722782904128522 1 GO:0017018 myosin phosphatase activity 11/2774 84/18639 0.130952380952381 0.879892367906067 0.723038813040787 1 GO:0051117 ATPase binding 11/2774 84/18639 0.130952380952381 0.879892367906067 0.723038813040787 1 GO:0000149 SNARE binding 14/2774 106/18639 0.132075471698113 0.887438614629103 0.726669077746461 1 GO:0015297 antiporter activity 18/2774 135/18639 0.133333333333333 0.895890410958904 0.729602919888863 1 GO:0015036 disulfide oxidoreductase activity 5/2774 40/18639 0.125 0.839897260273973 0.73029089908542 1 GO:0050997 quaternary ammonium group binding 5/2774 40/18639 0.125 0.839897260273973 0.73029089908542 1 GO:0031490 chromatin DNA binding 17/2774 128/18639 0.1328125 0.892390839041096 0.731643858985624 1 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 17/2774 128/18639 0.1328125 0.892390839041096 0.731643858985624 1 GO:0052689 carboxylic ester hydrolase activity 12/2774 92/18639 0.130434782608696 0.876414532459797 0.733376982683229 1 GO:0005507 copper ion binding 8/2774 63/18639 0.126984126984127 0.853228962818004 0.739278734045449 1 GO:0004709 MAP kinase kinase kinase activity 3/2774 25/18639 0.12 0.806301369863014 0.741309972182477 1 GO:0004549 tRNA-specific ribonuclease activity 2/2774 17/18639 0.117647058823529 0.790491539081386 0.743475136476154 1 GO:0005092 GDP-dissociation inhibitor activity 2/2774 17/18639 0.117647058823529 0.790491539081386 0.743475136476154 1 GO:0016018 cyclosporin A binding 2/2774 17/18639 0.117647058823529 0.790491539081386 0.743475136476154 1 GO:0030169 low-density lipoprotein particle binding 2/2774 17/18639 0.117647058823529 0.790491539081386 0.743475136476154 1 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 2/2774 17/18639 0.117647058823529 0.790491539081386 0.743475136476154 1 GO:0032183 SUMO binding 2/2774 17/18639 0.117647058823529 0.790491539081386 0.743475136476154 1 GO:0051787 misfolded protein binding 2/2774 17/18639 0.117647058823529 0.790491539081386 0.743475136476154 1 GO:1990226 histone methyltransferase binding 2/2774 17/18639 0.117647058823529 0.790491539081386 0.743475136476154 1 GO:0019956 chemokine binding 4/2774 33/18639 0.121212121212121 0.814445828144458 0.744831882026874 1 GO:0140311 protein sequestering activity 4/2774 33/18639 0.121212121212121 0.814445828144458 0.744831882026874 1 GO:0004812 aminoacyl-tRNA ligase activity 5/2774 41/18639 0.121951219512195 0.8194119612429 0.750485799109192 1 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 5/2774 41/18639 0.121951219512195 0.8194119612429 0.750485799109192 1 GO:0016875 ligase activity, forming carbon-oxygen bonds 5/2774 41/18639 0.121951219512195 0.8194119612429 0.750485799109192 1 GO:0016877 ligase activity, forming carbon-sulfur bonds 5/2774 41/18639 0.121951219512195 0.8194119612429 0.750485799109192 1 GO:0005004 GPI-linked ephrin receptor activity 6/2774 49/18639 0.122448979591837 0.822756499860218 0.756997858299138 1 GO:0005008 hepatocyte growth factor receptor activity 6/2774 49/18639 0.122448979591837 0.822756499860218 0.756997858299138 1 GO:0005009 insulin receptor activity 6/2774 49/18639 0.122448979591837 0.822756499860218 0.756997858299138 1 GO:0005011 macrophage colony-stimulating factor receptor activity 6/2774 49/18639 0.122448979591837 0.822756499860218 0.756997858299138 1 GO:0005018 platelet-derived growth factor alpha-receptor activity 6/2774 49/18639 0.122448979591837 0.822756499860218 0.756997858299138 1 GO:0005020 stem cell factor receptor activity 6/2774 49/18639 0.122448979591837 0.822756499860218 0.756997858299138 1 GO:0008288 boss receptor activity 6/2774 49/18639 0.122448979591837 0.822756499860218 0.756997858299138 1 GO:0036332 placental growth factor receptor activity 6/2774 49/18639 0.122448979591837 0.822756499860218 0.756997858299138 1 GO:0038062 protein tyrosine kinase collagen receptor activity 6/2774 49/18639 0.122448979591837 0.822756499860218 0.756997858299138 1 GO:0060175 brain-derived neurotrophic factor receptor activity 6/2774 49/18639 0.122448979591837 0.822756499860218 0.756997858299138 1 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 3/2774 26/18639 0.115384615384615 0.775289778714436 0.765618116790729 1 GO:0019865 immunoglobulin binding 3/2774 26/18639 0.115384615384615 0.775289778714436 0.765618116790729 1 GO:0070412 R-SMAD binding 3/2774 26/18639 0.115384615384615 0.775289778714436 0.765618116790729 1 GO:0120014 phospholipid transfer activity 3/2774 26/18639 0.115384615384615 0.775289778714436 0.765618116790729 1 GO:0015035 protein-disulfide reductase activity 4/2774 34/18639 0.117647058823529 0.790491539081386 0.766130828417368 1 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 4/2774 34/18639 0.117647058823529 0.790491539081386 0.766130828417368 1 GO:0052866 phosphatidylinositol phosphate phosphatase activity 4/2774 34/18639 0.117647058823529 0.790491539081386 0.766130828417368 1 GO:0090482 vitamin transmembrane transporter activity 4/2774 34/18639 0.117647058823529 0.790491539081386 0.766130828417368 1 GO:0099106 ion channel regulator activity 21/2774 160/18639 0.13125 0.881892123287671 0.76642695400207 1 GO:0031492 nucleosomal DNA binding 5/2774 42/18639 0.119047619047619 0.799902152641879 0.769532119073164 1 GO:0038024 cargo receptor activity 8/2774 65/18639 0.123076923076923 0.826975763962065 0.770691224786762 1 GO:0030228 lipoprotein particle receptor activity 2/2774 18/18639 0.111111111111111 0.746575342465753 0.772065494173053 1 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 2/2774 18/18639 0.111111111111111 0.746575342465753 0.772065494173053 1 GO:1901681 sulfur compound binding 37/2774 275/18639 0.134545454545455 0.904034869240349 0.772587651877131 1 GO:0004867 serine-type endopeptidase inhibitor activity 12/2774 95/18639 0.126315789473684 0.84873828406633 0.772859881237132 1 GO:0016247 channel regulator activity 22/2774 168/18639 0.130952380952381 0.879892367906067 0.774047953568303 1 GO:0005006 epidermal growth factor receptor activity 6/2774 50/18639 0.12 0.806301369863014 0.774275893099331 1 GO:0005007 fibroblast growth factor receptor activity 6/2774 50/18639 0.12 0.806301369863014 0.774275893099331 1 GO:0005017 platelet-derived growth factor receptor activity 6/2774 50/18639 0.12 0.806301369863014 0.774275893099331 1 GO:0005019 platelet-derived growth factor beta-receptor activity 6/2774 50/18639 0.12 0.806301369863014 0.774275893099331 1 GO:0061631 ubiquitin conjugating enzyme activity 4/2774 35/18639 0.114285714285714 0.767906066536203 0.786012996317391 1 GO:0008200 ion channel inhibitor activity 5/2774 43/18639 0.116279069767442 0.781299776999044 0.787448897388242 1 GO:0008266 poly(U) RNA binding 3/2774 27/18639 0.111111111111111 0.746575342465753 0.788031506847369 1 GO:0015252 proton channel activity 3/2774 27/18639 0.111111111111111 0.746575342465753 0.788031506847369 1 GO:0016405 CoA-ligase activity 3/2774 27/18639 0.111111111111111 0.746575342465753 0.788031506847369 1 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 3/2774 27/18639 0.111111111111111 0.746575342465753 0.788031506847369 1 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 3/2774 27/18639 0.111111111111111 0.746575342465753 0.788031506847369 1 GO:0005010 insulin-like growth factor receptor activity 6/2774 51/18639 0.117647058823529 0.790491539081386 0.790615053569015 1 GO:0005021 vascular endothelial growth factor receptor activity 6/2774 51/18639 0.117647058823529 0.790491539081386 0.790615053569015 1 GO:0005030 neurotrophin receptor activity 6/2774 51/18639 0.117647058823529 0.790491539081386 0.790615053569015 1 GO:0141108 transporter regulator activity 22/2774 170/18639 0.129411764705882 0.869540692989525 0.792416033786124 1 GO:0070888 E-box binding 7/2774 59/18639 0.11864406779661 0.797190619921059 0.794697890422755 1 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 2/2774 19/18639 0.105263157894737 0.707281903388609 0.797831199636798 1 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 2/2774 19/18639 0.105263157894737 0.707281903388609 0.797831199636798 1 GO:0005229 intracellularly calcium-gated chloride channel activity 2/2774 19/18639 0.105263157894737 0.707281903388609 0.797831199636798 1 GO:0008301 DNA binding, bending 2/2774 19/18639 0.105263157894737 0.707281903388609 0.797831199636798 1 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 2/2774 19/18639 0.105263157894737 0.707281903388609 0.797831199636798 1 GO:0030506 ankyrin binding 2/2774 19/18639 0.105263157894737 0.707281903388609 0.797831199636798 1 GO:0043395 heparan sulfate proteoglycan binding 2/2774 19/18639 0.105263157894737 0.707281903388609 0.797831199636798 1 GO:0070003 threonine-type peptidase activity 2/2774 19/18639 0.105263157894737 0.707281903388609 0.797831199636798 1 GO:0141147 intracellularly calcium-gated channel activity 2/2774 19/18639 0.105263157894737 0.707281903388609 0.797831199636798 1 GO:1990380 K48-linked deubiquitinase activity 2/2774 19/18639 0.105263157894737 0.707281903388609 0.797831199636798 1 GO:0016500 protein-hormone receptor activity 8/2774 67/18639 0.119402985074627 0.802289920261705 0.799270314219583 1 GO:0000182 rDNA binding 1/2774 10/18639 0.1 0.671917808219178 0.80047777452641 1 GO:0004382 GDP phosphatase activity 1/2774 10/18639 0.1 0.671917808219178 0.80047777452641 1 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 1/2774 10/18639 0.1 0.671917808219178 0.80047777452641 1 GO:0004862 cAMP-dependent protein kinase inhibitor activity 1/2774 10/18639 0.1 0.671917808219178 0.80047777452641 1 GO:0005131 growth hormone receptor binding 1/2774 10/18639 0.1 0.671917808219178 0.80047777452641 1 GO:0005522 profilin binding 1/2774 10/18639 0.1 0.671917808219178 0.80047777452641 1 GO:0008190 eukaryotic initiation factor 4E binding 1/2774 10/18639 0.1 0.671917808219178 0.80047777452641 1 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 1/2774 10/18639 0.1 0.671917808219178 0.80047777452641 1 GO:0008401 retinoic acid 4-hydroxylase activity 1/2774 10/18639 0.1 0.671917808219178 0.80047777452641 1 GO:0008519 ammonium channel activity 1/2774 10/18639 0.1 0.671917808219178 0.80047777452641 1 GO:0008641 ubiquitin-like modifier activating enzyme activity 1/2774 10/18639 0.1 0.671917808219178 0.80047777452641 1 GO:0015187 glycine transmembrane transporter activity 1/2774 10/18639 0.1 0.671917808219178 0.80047777452641 1 GO:0015658 branched-chain amino acid transmembrane transporter activity 1/2774 10/18639 0.1 0.671917808219178 0.80047777452641 1 GO:0016175 superoxide-generating NAD(P)H oxidase activity 1/2774 10/18639 0.1 0.671917808219178 0.80047777452641 1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 1/2774 10/18639 0.1 0.671917808219178 0.80047777452641 1 GO:0016868 intramolecular phosphotransferase activity 1/2774 10/18639 0.1 0.671917808219178 0.80047777452641 1 GO:0031434 mitogen-activated protein kinase kinase binding 1/2774 10/18639 0.1 0.671917808219178 0.80047777452641 1 GO:0031720 haptoglobin binding 1/2774 10/18639 0.1 0.671917808219178 0.80047777452641 1 GO:0031957 very long-chain fatty acid-CoA ligase activity 1/2774 10/18639 0.1 0.671917808219178 0.80047777452641 1 GO:0033204 ribonuclease P RNA binding 1/2774 10/18639 0.1 0.671917808219178 0.80047777452641 1 GO:0035374 chondroitin sulfate binding 1/2774 10/18639 0.1 0.671917808219178 0.80047777452641 1 GO:0042166 acetylcholine binding 1/2774 10/18639 0.1 0.671917808219178 0.80047777452641 1 GO:0042975 peroxisome proliferator activated receptor binding 1/2774 10/18639 0.1 0.671917808219178 0.80047777452641 1 GO:0050308 sugar-phosphatase activity 1/2774 10/18639 0.1 0.671917808219178 0.80047777452641 1 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 1/2774 10/18639 0.1 0.671917808219178 0.80047777452641 1 GO:0050815 phosphoserine residue binding 1/2774 10/18639 0.1 0.671917808219178 0.80047777452641 1 GO:0070097 delta-catenin binding 1/2774 10/18639 0.1 0.671917808219178 0.80047777452641 1 GO:0099122 RNA polymerase II C-terminal domain binding 1/2774 10/18639 0.1 0.671917808219178 0.80047777452641 1 GO:0001223 transcription coactivator binding 5/2774 44/18639 0.113636363636364 0.76354296388543 0.804261805274261 1 GO:0016248 channel inhibitor activity 5/2774 44/18639 0.113636363636364 0.76354296388543 0.804261805274261 1 GO:0004033 aldo-keto reductase (NADPH) activity 4/2774 36/18639 0.111111111111111 0.746575342465753 0.80452127852235 1 GO:0016409 palmitoyltransferase activity 4/2774 36/18639 0.111111111111111 0.746575342465753 0.80452127852235 1 GO:0015291 secondary active transmembrane transporter activity 38/2774 287/18639 0.132404181184669 0.889647272206577 0.807028792565316 1 GO:0016866 intramolecular transferase activity 3/2774 28/18639 0.107142857142857 0.719911937377691 0.808634051057461 1 GO:0046625 sphingolipid binding 3/2774 28/18639 0.107142857142857 0.719911937377691 0.808634051057461 1 GO:0046875 ephrin receptor binding 3/2774 28/18639 0.107142857142857 0.719911937377691 0.808634051057461 1 GO:0032934 sterol binding 8/2774 68/18639 0.117647058823529 0.790491539081386 0.812516896377216 1 GO:0015108 chloride transmembrane transporter activity 15/2774 121/18639 0.12396694214876 0.832955960602287 0.814290740348846 1 GO:0019838 growth factor binding 17/2774 136/18639 0.125 0.839897260273973 0.815920741837535 1 GO:0008009 chemokine activity 5/2774 45/18639 0.111111111111111 0.746575342465753 0.820002014374802 1 GO:0140303 intramembrane lipid transporter activity 5/2774 45/18639 0.111111111111111 0.746575342465753 0.820002014374802 1 GO:0141110 transporter inhibitor activity 5/2774 45/18639 0.111111111111111 0.746575342465753 0.820002014374802 1 GO:0005003 ephrin receptor activity 6/2774 53/18639 0.113207547169811 0.760661669682088 0.8205500982626 1 GO:0005005 transmembrane-ephrin receptor activity 6/2774 53/18639 0.113207547169811 0.760661669682088 0.8205500982626 1 GO:0001972 retinoic acid binding 2/2774 20/18639 0.1 0.671917808219178 0.820979436608988 1 GO:0015464 acetylcholine receptor activity 2/2774 20/18639 0.1 0.671917808219178 0.820979436608988 1 GO:0016004 phospholipase activator activity 2/2774 20/18639 0.1 0.671917808219178 0.820979436608988 1 GO:0016408 C-acyltransferase activity 2/2774 20/18639 0.1 0.671917808219178 0.820979436608988 1 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 2/2774 20/18639 0.1 0.671917808219178 0.820979436608988 1 GO:0052745 inositol phosphate phosphatase activity 2/2774 20/18639 0.1 0.671917808219178 0.820979436608988 1 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 15/2774 122/18639 0.122950819672131 0.826128452728498 0.823874180573586 1 GO:0051861 glycolipid binding 3/2774 29/18639 0.103448275862069 0.695087387812943 0.827517921241884 1 GO:0099604 ligand-gated calcium channel activity 3/2774 29/18639 0.103448275862069 0.695087387812943 0.827517921241884 1 GO:0033218 amide binding 32/2774 247/18639 0.129554655870445 0.870500804170595 0.827674180379318 1 GO:0004016 adenylate cyclase activity 1/2774 11/18639 0.0909090909090909 0.610834371108344 0.830188153691353 1 GO:0004523 RNA-DNA hybrid ribonuclease activity 1/2774 11/18639 0.0909090909090909 0.610834371108344 0.830188153691353 1 GO:0008172 S-methyltransferase activity 1/2774 11/18639 0.0909090909090909 0.610834371108344 0.830188153691353 1 GO:0008199 ferric iron binding 1/2774 11/18639 0.0909090909090909 0.610834371108344 0.830188153691353 1 GO:0008432 JUN kinase binding 1/2774 11/18639 0.0909090909090909 0.610834371108344 0.830188153691353 1 GO:0008526 phosphatidylinositol transfer activity 1/2774 11/18639 0.0909090909090909 0.610834371108344 0.830188153691353 1 GO:0010854 adenylate cyclase regulator activity 1/2774 11/18639 0.0909090909090909 0.610834371108344 0.830188153691353 1 GO:0015173 aromatic amino acid transmembrane transporter activity 1/2774 11/18639 0.0909090909090909 0.610834371108344 0.830188153691353 1 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 1/2774 11/18639 0.0909090909090909 0.610834371108344 0.830188153691353 1 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 1/2774 11/18639 0.0909090909090909 0.610834371108344 0.830188153691353 1 GO:0019107 myristoyltransferase activity 1/2774 11/18639 0.0909090909090909 0.610834371108344 0.830188153691353 1 GO:0019203 carbohydrate phosphatase activity 1/2774 11/18639 0.0909090909090909 0.610834371108344 0.830188153691353 1 GO:0035252 UDP-xylosyltransferase activity 1/2774 11/18639 0.0909090909090909 0.610834371108344 0.830188153691353 1 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 1/2774 11/18639 0.0909090909090909 0.610834371108344 0.830188153691353 1 GO:0042285 xylosyltransferase activity 1/2774 11/18639 0.0909090909090909 0.610834371108344 0.830188153691353 1 GO:0048185 activin binding 1/2774 11/18639 0.0909090909090909 0.610834371108344 0.830188153691353 1 GO:0048407 platelet-derived growth factor binding 1/2774 11/18639 0.0909090909090909 0.610834371108344 0.830188153691353 1 GO:0180030 inositol phosphate kinase activity 1/2774 11/18639 0.0909090909090909 0.610834371108344 0.830188153691353 1 GO:0004843 cysteine-type deubiquitinase activity 13/2774 108/18639 0.12037037037037 0.808789954337899 0.833502404983311 1 GO:0017069 snRNA binding 6/2774 54/18639 0.111111111111111 0.746575342465753 0.834192517180133 1 GO:0004180 carboxypeptidase activity 5/2774 46/18639 0.108695652173913 0.730345443716498 0.834705152819307 1 GO:0008028 monocarboxylic acid transmembrane transporter activity 8/2774 70/18639 0.114285714285714 0.767906066536203 0.836987151455506 1 GO:0019199 transmembrane receptor protein kinase activity 9/2774 78/18639 0.115384615384615 0.775289778714436 0.839429470117846 1 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 2/2774 21/18639 0.0952380952380952 0.639921722113503 0.841718303318337 1 GO:0005248 voltage-gated sodium channel activity 2/2774 21/18639 0.0952380952380952 0.639921722113503 0.841718303318337 1 GO:0009975 cyclase activity 2/2774 21/18639 0.0952380952380952 0.639921722113503 0.841718303318337 1 GO:0015174 basic amino acid transmembrane transporter activity 2/2774 21/18639 0.0952380952380952 0.639921722113503 0.841718303318337 1 GO:0036122 BMP binding 2/2774 21/18639 0.0952380952380952 0.639921722113503 0.841718303318337 1 GO:0072542 protein phosphatase activator activity 2/2774 21/18639 0.0952380952380952 0.639921722113503 0.841718303318337 1 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 3/2774 30/18639 0.1 0.671917808219178 0.844780537867118 1 GO:0008187 poly-pyrimidine tract binding 3/2774 30/18639 0.1 0.671917808219178 0.844780537867118 1 GO:0008237 metallopeptidase activity 23/2774 184/18639 0.125 0.839897260273973 0.845763668554152 1 GO:0140313 molecular sequestering activity 6/2774 55/18639 0.109090909090909 0.733001245330012 0.846987821228279 1 GO:0043495 protein-membrane adaptor activity 5/2774 47/18639 0.106382978723404 0.714806178956573 0.848410353299658 1 GO:0003720 telomerase activity 1/2774 12/18639 0.0833333333333333 0.559931506849315 0.855475788523874 1 GO:0004526 ribonuclease P activity 1/2774 12/18639 0.0833333333333333 0.559931506849315 0.855475788523874 1 GO:0004875 complement receptor activity 1/2774 12/18639 0.0833333333333333 0.559931506849315 0.855475788523874 1 GO:0005247 voltage-gated chloride channel activity 1/2774 12/18639 0.0833333333333333 0.559931506849315 0.855475788523874 1 GO:0008504 monoamine transmembrane transporter activity 1/2774 12/18639 0.0833333333333333 0.559931506849315 0.855475788523874 1 GO:0008603 cAMP-dependent protein kinase regulator activity 1/2774 12/18639 0.0833333333333333 0.559931506849315 0.855475788523874 1 GO:0015368 calcium:monoatomic cation antiporter activity 1/2774 12/18639 0.0833333333333333 0.559931506849315 0.855475788523874 1 GO:0016801 hydrolase activity, acting on ether bonds 1/2774 12/18639 0.0833333333333333 0.559931506849315 0.855475788523874 1 GO:0016803 ether hydrolase activity 1/2774 12/18639 0.0833333333333333 0.559931506849315 0.855475788523874 1 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 1/2774 12/18639 0.0833333333333333 0.559931506849315 0.855475788523874 1 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 1/2774 12/18639 0.0833333333333333 0.559931506849315 0.855475788523874 1 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 1/2774 12/18639 0.0833333333333333 0.559931506849315 0.855475788523874 1 GO:1990247 N6-methyladenosine-containing RNA reader activity 1/2774 12/18639 0.0833333333333333 0.559931506849315 0.855475788523874 1 GO:1990459 transferrin receptor binding 1/2774 12/18639 0.0833333333333333 0.559931506849315 0.855475788523874 1 GO:1990817 poly(A) RNA polymerase activity 1/2774 12/18639 0.0833333333333333 0.559931506849315 0.855475788523874 1 GO:0170055 lipid transmembrane transporter activity 6/2774 56/18639 0.107142857142857 0.719911937377691 0.858966274828582 1 GO:0008970 phospholipase A1 activity 2/2774 22/18639 0.0909090909090909 0.610834371108344 0.860251952795733 1 GO:0031683 G-protein beta/gamma-subunit complex binding 2/2774 22/18639 0.0909090909090909 0.610834371108344 0.860251952795733 1 GO:0034062 5'-3' RNA polymerase activity 2/2774 22/18639 0.0909090909090909 0.610834371108344 0.860251952795733 1 GO:0070034 telomerase RNA binding 2/2774 22/18639 0.0909090909090909 0.610834371108344 0.860251952795733 1 GO:0097747 RNA polymerase activity 2/2774 22/18639 0.0909090909090909 0.610834371108344 0.860251952795733 1 GO:0047499 calcium-independent phospholipase A2 activity 3/2774 31/18639 0.0967741935483871 0.650243040212108 0.860522075493523 1 GO:0005200 structural constituent of cytoskeleton 13/2774 112/18639 0.116071428571429 0.779904598825832 0.868583825564577 1 GO:0003727 single-stranded RNA binding 10/2774 89/18639 0.112359550561798 0.754963829459751 0.87079717026473 1 GO:0008514 organic anion transmembrane transporter activity 34/2774 269/18639 0.12639405204461 0.849264144217548 0.871603562622154 1 GO:0030515 snoRNA binding 3/2774 32/18639 0.09375 0.629922945205479 0.874843429069795 1 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 3/2774 32/18639 0.09375 0.629922945205479 0.874843429069795 1 GO:0047498 calcium-dependent phospholipase A2 activity 3/2774 32/18639 0.09375 0.629922945205479 0.874843429069795 1 GO:0070717 poly-purine tract binding 3/2774 32/18639 0.09375 0.629922945205479 0.874843429069795 1 GO:0120015 sterol transfer activity 3/2774 32/18639 0.09375 0.629922945205479 0.874843429069795 1 GO:0005158 insulin receptor binding 2/2774 23/18639 0.0869565217391304 0.584276354973198 0.87677715856344 1 GO:0005283 amino acid:sodium symporter activity 2/2774 23/18639 0.0869565217391304 0.584276354973198 0.87677715856344 1 GO:0016849 phosphorus-oxygen lyase activity 2/2774 23/18639 0.0869565217391304 0.584276354973198 0.87677715856344 1 GO:0099186 structural constituent of postsynapse 2/2774 23/18639 0.0869565217391304 0.584276354973198 0.87677715856344 1 GO:0004535 poly(A)-specific ribonuclease activity 1/2774 13/18639 0.0769230769230769 0.516859852476291 0.87699885518167 1 GO:0008417 fucosyltransferase activity 1/2774 13/18639 0.0769230769230769 0.516859852476291 0.87699885518167 1 GO:0015651 quaternary ammonium group transmembrane transporter activity 1/2774 13/18639 0.0769230769230769 0.516859852476291 0.87699885518167 1 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 1/2774 13/18639 0.0769230769230769 0.516859852476291 0.87699885518167 1 GO:0017154 semaphorin receptor activity 1/2774 13/18639 0.0769230769230769 0.516859852476291 0.87699885518167 1 GO:0019855 calcium channel inhibitor activity 1/2774 13/18639 0.0769230769230769 0.516859852476291 0.87699885518167 1 GO:0031994 insulin-like growth factor I binding 1/2774 13/18639 0.0769230769230769 0.516859852476291 0.87699885518167 1 GO:0032396 inhibitory MHC class I receptor activity 1/2774 13/18639 0.0769230769230769 0.516859852476291 0.87699885518167 1 GO:0089720 caspase binding 1/2774 13/18639 0.0769230769230769 0.516859852476291 0.87699885518167 1 GO:0097157 pre-mRNA intronic binding 1/2774 13/18639 0.0769230769230769 0.516859852476291 0.87699885518167 1 GO:0061650 ubiquitin-like protein conjugating enzyme activity 4/2774 41/18639 0.0975609756097561 0.65552956899432 0.878364304051412 1 GO:0042626 ATPase-coupled transmembrane transporter activity 11/2774 98/18639 0.112244897959184 0.7541934582052 0.880541905423216 1 GO:0035198 miRNA binding 4/2774 42/18639 0.0952380952380952 0.639921722113503 0.889820323522806 1 GO:0042056 chemoattractant activity 4/2774 42/18639 0.0952380952380952 0.639921722113503 0.889820323522806 1 GO:0048487 beta-tubulin binding 4/2774 42/18639 0.0952380952380952 0.639921722113503 0.889820323522806 1 GO:0005178 integrin binding 19/2774 161/18639 0.118012422360248 0.792946481749341 0.890530482668172 1 GO:0005315 phosphate transmembrane transporter activity 2/2774 24/18639 0.0833333333333333 0.559931506849315 0.891480989296099 1 GO:0050431 transforming growth factor beta binding 2/2774 24/18639 0.0833333333333333 0.559931506849315 0.891480989296099 1 GO:0005272 sodium channel activity 5/2774 51/18639 0.0980392156862745 0.658742949234488 0.894111539901784 1 GO:0004065 arylsulfatase activity 1/2774 14/18639 0.0714285714285714 0.479941291585127 0.895317612602804 1 GO:0008191 metalloendopeptidase inhibitor activity 1/2774 14/18639 0.0714285714285714 0.479941291585127 0.895317612602804 1 GO:0008474 palmitoyl-(protein) hydrolase activity 1/2774 14/18639 0.0714285714285714 0.479941291585127 0.895317612602804 1 GO:0008494 translation activator activity 1/2774 14/18639 0.0714285714285714 0.479941291585127 0.895317612602804 1 GO:0016530 metallochaperone activity 1/2774 14/18639 0.0714285714285714 0.479941291585127 0.895317612602804 1 GO:0019992 diacylglycerol binding 1/2774 14/18639 0.0714285714285714 0.479941291585127 0.895317612602804 1 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 1/2774 14/18639 0.0714285714285714 0.479941291585127 0.895317612602804 1 GO:0042813 Wnt receptor activity 1/2774 14/18639 0.0714285714285714 0.479941291585127 0.895317612602804 1 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 1/2774 14/18639 0.0714285714285714 0.479941291585127 0.895317612602804 1 GO:0098599 palmitoyl hydrolase activity 1/2774 14/18639 0.0714285714285714 0.479941291585127 0.895317612602804 1 GO:1901474 azole transmembrane transporter activity 1/2774 14/18639 0.0714285714285714 0.479941291585127 0.895317612602804 1 GO:0017022 myosin binding 8/2774 76/18639 0.105263157894737 0.707281903388609 0.895496436218703 1 GO:0004714 transmembrane receptor protein tyrosine kinase activity 6/2774 60/18639 0.1 0.671917808219178 0.899369678939965 1 GO:0015020 glucuronosyltransferase activity 3/2774 34/18639 0.0882352941176471 0.59286865431104 0.899623334292479 1 GO:0005319 lipid transporter activity 21/2774 178/18639 0.117977528089888 0.792712020932738 0.900679450727219 1 GO:0015645 fatty acid ligase activity 2/2774 25/18639 0.08 0.537534246575343 0.904539338610326 1 GO:0015662 P-type ion transporter activity 2/2774 25/18639 0.08 0.537534246575343 0.904539338610326 1 GO:0019211 phosphatase activator activity 2/2774 25/18639 0.08 0.537534246575343 0.904539338610326 1 GO:0120020 cholesterol transfer activity 2/2774 25/18639 0.08 0.537534246575343 0.904539338610326 1 GO:0120515 fatty acid-CoA ligase activity 2/2774 25/18639 0.08 0.537534246575343 0.904539338610326 1 GO:0140358 P-type transmembrane transporter activity 2/2774 25/18639 0.08 0.537534246575343 0.904539338610326 1 GO:0004623 phospholipase A2 activity 3/2774 35/18639 0.0857142857142857 0.575929549902153 0.910274303477644 1 GO:0005343 organic acid:sodium symporter activity 3/2774 35/18639 0.0857142857142857 0.575929549902153 0.910274303477644 1 GO:0016229 steroid dehydrogenase activity 3/2774 35/18639 0.0857142857142857 0.575929549902153 0.910274303477644 1 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 1/2774 15/18639 0.0666666666666667 0.447945205479452 0.910908965227761 1 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 1/2774 15/18639 0.0666666666666667 0.447945205479452 0.910908965227761 1 GO:0005041 low-density lipoprotein particle receptor activity 1/2774 15/18639 0.0666666666666667 0.447945205479452 0.910908965227761 1 GO:0015250 water channel activity 1/2774 15/18639 0.0666666666666667 0.447945205479452 0.910908965227761 1 GO:0050780 dopamine receptor binding 1/2774 15/18639 0.0666666666666667 0.447945205479452 0.910908965227761 1 GO:0140161 monocarboxylate:sodium symporter activity 1/2774 15/18639 0.0666666666666667 0.447945205479452 0.910908965227761 1 GO:0008146 sulfotransferase activity 5/2774 53/18639 0.0943396226415094 0.633884724735074 0.912120339505382 1 GO:0046943 carboxylic acid transmembrane transporter activity 22/2774 188/18639 0.117021276595745 0.78628679685223 0.912505445862856 1 GO:0061134 peptidase regulator activity 27/2774 226/18639 0.119469026548673 0.802733664686629 0.913351288359469 1 GO:0005160 transforming growth factor beta receptor binding 2/2774 26/18639 0.0769230769230769 0.516859852476291 0.916116107095293 1 GO:0008143 poly(A) binding 2/2774 26/18639 0.0769230769230769 0.516859852476291 0.916116107095293 1 GO:0030247 polysaccharide binding 2/2774 26/18639 0.0769230769230769 0.516859852476291 0.916116107095293 1 GO:0043548 phosphatidylinositol 3-kinase binding 2/2774 26/18639 0.0769230769230769 0.516859852476291 0.916116107095293 1 GO:0097602 cullin family protein binding 2/2774 26/18639 0.0769230769230769 0.516859852476291 0.916116107095293 1 GO:0005342 organic acid transmembrane transporter activity 22/2774 189/18639 0.116402116402116 0.782126549249837 0.917029019070369 1 GO:0015370 solute:sodium symporter activity 8/2774 79/18639 0.10126582278481 0.680423096930813 0.917415730274267 1 GO:0004190 aspartic-type endopeptidase activity 3/2774 36/18639 0.0833333333333333 0.559931506849315 0.919888214837216 1 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 5/2774 54/18639 0.0925925925925926 0.622146118721461 0.920072158109999 1 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 1/2774 16/18639 0.0625 0.419948630136986 0.924178860548755 1 GO:0005149 interleukin-1 receptor binding 1/2774 16/18639 0.0625 0.419948630136986 0.924178860548755 1 GO:0015378 sodium:chloride symporter activity 1/2774 16/18639 0.0625 0.419948630136986 0.924178860548755 1 GO:0016722 oxidoreductase activity, acting on metal ions 1/2774 16/18639 0.0625 0.419948630136986 0.924178860548755 1 GO:0022841 potassium ion leak channel activity 1/2774 16/18639 0.0625 0.419948630136986 0.924178860548755 1 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity 1/2774 16/18639 0.0625 0.419948630136986 0.924178860548755 1 GO:0031435 mitogen-activated protein kinase kinase kinase binding 1/2774 16/18639 0.0625 0.419948630136986 0.924178860548755 1 GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 1/2774 16/18639 0.0625 0.419948630136986 0.924178860548755 1 GO:0061135 endopeptidase regulator activity 21/2774 184/18639 0.114130434782609 0.766862715902323 0.928244288013595 1 GO:0070001 aspartic-type peptidase activity 3/2774 37/18639 0.0810810810810811 0.544798222880415 0.928551377969049 1 GO:0004497 monooxygenase activity 11/2774 106/18639 0.10377358490566 0.697273197208581 0.931489907171719 1 GO:0008527 taste receptor activity 2/2774 28/18639 0.0714285714285714 0.479941291585127 0.935418938504178 1 GO:0051537 2 iron, 2 sulfur cluster binding 2/2774 28/18639 0.0714285714285714 0.479941291585127 0.935418938504178 1 GO:0008429 phosphatidylethanolamine binding 1/2774 17/18639 0.0588235294117647 0.395245769540693 0.935472843303293 1 GO:0008484 sulfuric ester hydrolase activity 1/2774 17/18639 0.0588235294117647 0.395245769540693 0.935472843303293 1 GO:0031489 myosin V binding 1/2774 17/18639 0.0588235294117647 0.395245769540693 0.935472843303293 1 GO:0036041 long-chain fatty acid binding 1/2774 17/18639 0.0588235294117647 0.395245769540693 0.935472843303293 1 GO:0045236 CXCR chemokine receptor binding 1/2774 17/18639 0.0588235294117647 0.395245769540693 0.935472843303293 1 GO:0070492 oligosaccharide binding 1/2774 17/18639 0.0588235294117647 0.395245769540693 0.935472843303293 1 GO:0005109 frizzled binding 3/2774 38/18639 0.0789473684210526 0.530461427541456 0.936345350683169 1 GO:0043531 ADP binding 3/2774 38/18639 0.0789473684210526 0.530461427541456 0.936345350683169 1 GO:0005254 chloride channel activity 8/2774 83/18639 0.0963855421686747 0.647631622379931 0.940411072999633 1 GO:0004181 metallocarboxypeptidase activity 2/2774 29/18639 0.0689655172413793 0.463391591875295 0.943411606449533 1 GO:0005416 amino acid:monoatomic cation symporter activity 2/2774 29/18639 0.0689655172413793 0.463391591875295 0.943411606449533 1 GO:0015103 inorganic anion transmembrane transporter activity 18/2774 165/18639 0.109090909090909 0.733001245330012 0.944414842922078 1 GO:0004970 glutamate-gated receptor activity 1/2774 18/18639 0.0555555555555556 0.373287671232877 0.945085040310954 1 GO:0005372 water transmembrane transporter activity 1/2774 18/18639 0.0555555555555556 0.373287671232877 0.945085040310954 1 GO:0015373 monoatomic anion:sodium symporter activity 1/2774 18/18639 0.0555555555555556 0.373287671232877 0.945085040310954 1 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 1/2774 18/18639 0.0555555555555556 0.373287671232877 0.945085040310954 1 GO:0022851 GABA-gated chloride ion channel activity 1/2774 18/18639 0.0555555555555556 0.373287671232877 0.945085040310954 1 GO:0050840 extracellular matrix binding 6/2774 67/18639 0.0895522388059701 0.601717440196279 0.946438124770925 1 GO:0015171 amino acid transmembrane transporter activity 10/2774 102/18639 0.0980392156862745 0.658742949234488 0.950193950359626 1 GO:0001968 fibronectin binding 2/2774 30/18639 0.0666666666666667 0.447945205479452 0.950456682776848 1 GO:0098918 structural constituent of synapse 2/2774 30/18639 0.0666666666666667 0.447945205479452 0.950456682776848 1 GO:0015459 potassium channel regulator activity 5/2774 59/18639 0.0847457627118644 0.569421871372185 0.951002494537979 1 GO:0003756 protein disulfide isomerase activity 1/2774 19/18639 0.0526315789473684 0.353640951694304 0.953265809237296 1 GO:0004890 GABA-A receptor activity 1/2774 19/18639 0.0526315789473684 0.353640951694304 0.953265809237296 1 GO:0005520 insulin-like growth factor binding 1/2774 19/18639 0.0526315789473684 0.353640951694304 0.953265809237296 1 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 1/2774 19/18639 0.0526315789473684 0.353640951694304 0.953265809237296 1 GO:0022840 leak channel activity 1/2774 19/18639 0.0526315789473684 0.353640951694304 0.953265809237296 1 GO:0022842 narrow pore channel activity 1/2774 19/18639 0.0526315789473684 0.353640951694304 0.953265809237296 1 GO:0034987 immunoglobulin receptor binding 1/2774 19/18639 0.0526315789473684 0.353640951694304 0.953265809237296 1 GO:0042800 histone H3K4 methyltransferase activity 1/2774 19/18639 0.0526315789473684 0.353640951694304 0.953265809237296 1 GO:0097001 ceramide binding 1/2774 19/18639 0.0526315789473684 0.353640951694304 0.953265809237296 1 GO:0001530 lipopolysaccharide binding 3/2774 41/18639 0.0731707317073171 0.49164717674574 0.955253170933041 1 GO:0140828 metal cation:monoatomic cation antiporter activity 3/2774 41/18639 0.0731707317073171 0.49164717674574 0.955253170933041 1 GO:0005184 neuropeptide hormone activity 2/2774 31/18639 0.0645161290322581 0.433495360141405 0.956659069486043 1 GO:0017147 Wnt-protein binding 2/2774 31/18639 0.0645161290322581 0.433495360141405 0.956659069486043 1 GO:0004866 endopeptidase inhibitor activity 17/2774 161/18639 0.105590062111801 0.709478431038884 0.956707651528051 1 GO:0005048 signal sequence binding 4/2774 51/18639 0.0784313725490196 0.526994359387591 0.95698929231357 1 GO:0000339 RNA cap binding 1/2774 20/18639 0.05 0.335958904109589 0.960228249901944 1 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 1/2774 20/18639 0.05 0.335958904109589 0.960228249901944 1 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 1/2774 20/18639 0.05 0.335958904109589 0.960228249901944 1 GO:0010851 cyclase regulator activity 1/2774 20/18639 0.05 0.335958904109589 0.960228249901944 1 GO:0015095 magnesium ion transmembrane transporter activity 1/2774 20/18639 0.05 0.335958904109589 0.960228249901944 1 GO:0030742 GTP-dependent protein binding 1/2774 20/18639 0.05 0.335958904109589 0.960228249901944 1 GO:0022884 macromolecule transmembrane transporter activity 2/2774 32/18639 0.0625 0.419948630136986 0.962113445513793 1 GO:0042910 xenobiotic transmembrane transporter activity 2/2774 32/18639 0.0625 0.419948630136986 0.962113445513793 1 GO:0160041 neuropeptide activity 2/2774 32/18639 0.0625 0.419948630136986 0.962113445513793 1 GO:0070851 growth factor receptor binding 14/2774 139/18639 0.100719424460432 0.676751749285503 0.962945241304799 1 GO:0005245 voltage-gated calcium channel activity 3/2774 43/18639 0.0697674418604651 0.468779866199427 0.964783955131312 1 GO:0005246 calcium channel regulator activity 4/2774 53/18639 0.0754716981132075 0.507107779788059 0.965475032857518 1 GO:0015125 bile acid transmembrane transporter activity 1/2774 21/18639 0.0476190476190476 0.319960861056751 0.966153747231124 1 GO:0061891 calcium ion sensor activity 1/2774 21/18639 0.0476190476190476 0.319960861056751 0.966153747231124 1 GO:0003925 G protein activity 4/2774 54/18639 0.0740740740740741 0.497716894977169 0.969107262837319 1 GO:0020037 heme binding 14/2774 142/18639 0.0985915492957746 0.662454177117499 0.9701890281646 1 GO:0030021 extracellular matrix structural constituent conferring compression resistance 1/2774 22/18639 0.0454545454545455 0.305417185554172 0.971196689823285 1 GO:0033038 bitter taste receptor activity 1/2774 22/18639 0.0454545454545455 0.305417185554172 0.971196689823285 1 GO:0140784 metal ion sensor activity 1/2774 22/18639 0.0454545454545455 0.305417185554172 0.971196689823285 1 GO:0030246 carbohydrate binding 31/2774 280/18639 0.110714285714286 0.743909001956947 0.974276505143443 1 GO:0030414 peptidase inhibitor activity 17/2774 169/18639 0.100591715976331 0.675893653238226 0.974754983145834 1 GO:0019003 GDP binding 6/2774 75/18639 0.08 0.537534246575343 0.975298973104814 1 GO:0005212 structural constituent of eye lens 1/2774 23/18639 0.0434782608695652 0.292138177486599 0.975488486698733 1 GO:0016917 GABA receptor activity 1/2774 23/18639 0.0434782608695652 0.292138177486599 0.975488486698733 1 GO:0031681 G-protein beta-subunit binding 1/2774 23/18639 0.0434782608695652 0.292138177486599 0.975488486698733 1 GO:0070577 lysine-acetylated histone binding 1/2774 23/18639 0.0434782608695652 0.292138177486599 0.975488486698733 1 GO:0001664 G protein-coupled receptor binding 33/2774 297/18639 0.111111111111111 0.746575342465753 0.976239010154231 1 GO:0004869 cysteine-type endopeptidase inhibitor activity 2/2774 36/18639 0.0555555555555556 0.373287671232877 0.978027040140786 1 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 2/2774 36/18639 0.0555555555555556 0.373287671232877 0.978027040140786 1 GO:0099095 ligand-gated monoatomic anion channel activity 3/2774 47/18639 0.0638297872340425 0.428883707373943 0.9783985064377 1 GO:0030552 cAMP binding 1/2774 24/18639 0.0416666666666667 0.279965753424658 0.979140986585804 1 GO:0140033 acetylation-dependent protein binding 1/2774 24/18639 0.0416666666666667 0.279965753424658 0.979140986585804 1 GO:0008201 heparin binding 17/2774 172/18639 0.0988372093023256 0.664104810449188 0.979552216739726 1 GO:0061980 regulatory RNA binding 4/2774 58/18639 0.0689655172413793 0.463391591875295 0.980352605099415 1 GO:0022829 wide pore channel activity 2/2774 37/18639 0.0540540540540541 0.36319881525361 0.980854220836314 1 GO:0030280 structural constituent of skin epidermis 2/2774 37/18639 0.0540540540540541 0.36319881525361 0.980854220836314 1 GO:0030551 cyclic nucleotide binding 2/2774 37/18639 0.0540540540540541 0.36319881525361 0.980854220836314 1 GO:0001848 complement binding 1/2774 25/18639 0.04 0.268767123287671 0.982249388584782 1 GO:0005251 delayed rectifier potassium channel activity 1/2774 25/18639 0.04 0.268767123287671 0.982249388584782 1 GO:0005537 D-mannose binding 1/2774 25/18639 0.04 0.268767123287671 0.982249388584782 1 GO:0015271 outward rectifier potassium channel activity 1/2774 25/18639 0.04 0.268767123287671 0.982249388584782 1 GO:0017056 structural constituent of nuclear pore 1/2774 25/18639 0.04 0.268767123287671 0.982249388584782 1 GO:0019706 protein-cysteine S-palmitoyltransferase activity 1/2774 25/18639 0.04 0.268767123287671 0.982249388584782 1 GO:0019707 protein-cysteine S-acyltransferase activity 1/2774 25/18639 0.04 0.268767123287671 0.982249388584782 1 GO:0036002 pre-mRNA binding 4/2774 59/18639 0.0677966101694915 0.455537497097748 0.982487158594793 1 GO:0005501 retinoid binding 2/2774 38/18639 0.0526315789473684 0.353640951694304 0.983326935844822 1 GO:0019840 isoprenoid binding 2/2774 38/18639 0.0526315789473684 0.353640951694304 0.983326935844822 1 GO:0008066 glutamate receptor activity 1/2774 26/18639 0.0384615384615385 0.258429926238145 0.984894719844362 1 GO:0051139 metal cation:proton antiporter activity 1/2774 26/18639 0.0384615384615385 0.258429926238145 0.984894719844362 1 GO:0005201 extracellular matrix structural constituent 16/2774 168/18639 0.0952380952380952 0.639921722113503 0.985066991586669 1 GO:0046982 protein heterodimerization activity 41/2774 369/18639 0.111111111111111 0.746575342465753 0.986020908597199 1 GO:0046906 tetrapyrrole binding 14/2774 152/18639 0.0921052631578947 0.618871665465032 0.986076346027723 1 GO:0005044 scavenger receptor activity 1/2774 27/18639 0.037037037037037 0.248858447488584 0.98714594464164 1 GO:0008320 protein transmembrane transporter activity 1/2774 27/18639 0.037037037037037 0.248858447488584 0.98714594464164 1 GO:0071855 neuropeptide receptor binding 2/2774 40/18639 0.05 0.335958904109589 0.987375441446597 1 GO:0099094 ligand-gated monoatomic cation channel activity 12/2774 136/18639 0.0882352941176471 0.59286865431104 0.987405426185809 1 GO:0005518 collagen binding 5/2774 72/18639 0.0694444444444444 0.466609589041096 0.987573171729556 1 GO:0008227 G protein-coupled amine receptor activity 2/2774 41/18639 0.0487804878048781 0.32776478449716 0.989022737370369 1 GO:0140318 protein transporter activity 2/2774 41/18639 0.0487804878048781 0.32776478449716 0.989022737370369 1 GO:0005242 inward rectifier potassium channel activity 1/2774 28/18639 0.0357142857142857 0.239970645792564 0.989061759683768 1 GO:0045499 chemorepellent activity 1/2774 28/18639 0.0357142857142857 0.239970645792564 0.989061759683768 1 GO:0050698 proteoglycan sulfotransferase activity 1/2774 28/18639 0.0357142857142857 0.239970645792564 0.989061759683768 1 GO:0042562 hormone binding 7/2774 94/18639 0.074468085106383 0.500364325269601 0.990640058194853 1 GO:0016417 S-acyltransferase activity 1/2774 29/18639 0.0344827586206897 0.231695795937648 0.990692122299277 1 GO:0106222 lncRNA binding 1/2774 29/18639 0.0344827586206897 0.231695795937648 0.990692122299277 1 GO:0033612 receptor serine/threonine kinase binding 1/2774 30/18639 0.0333333333333333 0.223972602739726 0.992079551248326 1 GO:0048019 receptor antagonist activity 1/2774 30/18639 0.0333333333333333 0.223972602739726 0.992079551248326 1 GO:0030547 signaling receptor inhibitor activity 2/2774 44/18639 0.0454545454545455 0.305417185554172 0.992803164240502 1 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 3/2774 56/18639 0.0535714285714286 0.359955968688845 0.993085992578548 1 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 2/2774 46/18639 0.0434782608695652 0.292138177486599 0.994580056634467 1 GO:0098960 postsynaptic neurotransmitter receptor activity 4/2774 69/18639 0.0579710144927536 0.389517569982132 0.994649573842839 1 GO:0015081 sodium ion transmembrane transporter activity 14/2774 164/18639 0.0853658536585366 0.57358837287003 0.994778124493494 1 GO:0042923 neuropeptide binding 1/2774 33/18639 0.0303030303030303 0.203611457036115 0.995119968588611 1 GO:0051427 hormone receptor binding 1/2774 34/18639 0.0294117647058824 0.197622884770347 0.995847540723148 1 GO:0008188 neuropeptide receptor activity 2/2774 48/18639 0.0416666666666667 0.279965753424658 0.995924492835336 1 GO:0038187 pattern recognition receptor activity 2/2774 48/18639 0.0416666666666667 0.279965753424658 0.995924492835336 1 GO:0015276 ligand-gated monoatomic ion channel activity 16/2774 186/18639 0.0860215053763441 0.577993813521874 0.996388219535792 1 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 4/2774 73/18639 0.0547945205479452 0.368174141489961 0.996722802519938 1 GO:0005267 potassium channel activity 9/2774 124/18639 0.0725806451612903 0.487682280159081 0.996898718468834 1 GO:0022834 ligand-gated channel activity 16/2774 188/18639 0.0851063829787234 0.571844943165258 0.99694172556437 1 GO:0022824 transmitter-gated monoatomic ion channel activity 3/2774 63/18639 0.0476190476190476 0.319960861056751 0.997234789918193 1 GO:0022835 transmitter-gated channel activity 3/2774 63/18639 0.0476190476190476 0.319960861056751 0.997234789918193 1 GO:0016597 amino acid binding 2/2774 51/18639 0.0392156862745098 0.263497179693795 0.997349575920134 1 GO:0015085 calcium ion transmembrane transporter activity 11/2774 147/18639 0.0748299319727891 0.502795638803467 0.997924431316968 1 GO:0017046 peptide hormone binding 2/2774 53/18639 0.0377358490566038 0.253553889894029 0.99801375076143 1 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 2/2774 53/18639 0.0377358490566038 0.253553889894029 0.99801375076143 1 GO:0004175 endopeptidase activity 41/2774 405/18639 0.101234567901235 0.680213089802131 0.998247377922151 1 GO:0004222 metalloendopeptidase activity 7/2774 110/18639 0.0636363636363636 0.427584059775841 0.998277980221772 1 GO:0005125 cytokine activity 20/2774 234/18639 0.0854700854700855 0.574288724973656 0.998748250658523 1 GO:0022832 voltage-gated channel activity 13/2774 175/18639 0.0742857142857143 0.499138943248532 0.999141298491887 1 GO:0042605 peptide antigen binding 1/2774 45/18639 0.0222222222222222 0.149315068493151 0.999297339169604 1 GO:0030594 neurotransmitter receptor activity 5/2774 97/18639 0.0515463917525773 0.346349385679989 0.999334071451223 1 GO:0005539 glycosaminoglycan binding 20/2774 242/18639 0.0826446280991736 0.555303973734858 0.999355061455803 1 GO:0005249 voltage-gated potassium channel activity 5/2774 98/18639 0.0510204081632653 0.342815208275091 0.99941112003557 1 GO:0015079 potassium ion transmembrane transporter activity 11/2774 160/18639 0.06875 0.461943493150685 0.999423634209738 1 GO:0005262 calcium channel activity 8/2774 131/18639 0.0610687022900763 0.410331485935376 0.99947569688621 1 GO:0022843 voltage-gated monoatomic cation channel activity 9/2774 143/18639 0.0629370629370629 0.422885333844238 0.999569825312974 1 GO:0005244 voltage-gated monoatomic ion channel activity 12/2774 173/18639 0.069364161849711 0.466070155990181 0.999586892723986 1 GO:0004252 serine-type endopeptidase activity 12/2774 176/18639 0.0681818181818182 0.458125778331258 0.999694312857228 1 GO:0003730 mRNA 3'-UTR binding 21/2774 262/18639 0.0801526717557252 0.538560075290181 0.999748359834713 1 GO:0042277 peptide binding 19/2774 249/18639 0.0763052208835341 0.512708367717445 0.999841431380812 1 GO:0046873 metal ion transmembrane transporter activity 42/2774 450/18639 0.0933333333333333 0.627123287671233 0.99984752668353 1 GO:0022836 gated channel activity 26/2774 318/18639 0.0817610062893082 0.549366761437064 0.999902607247028 1 GO:0005216 monoatomic ion channel activity 41/2774 448/18639 0.0915178571428571 0.614924779843444 0.999903443832036 1 GO:0017171 serine hydrolase activity 13/2774 198/18639 0.0656565656565657 0.441158156911582 0.999911669960333 1 GO:0008236 serine-type peptidase activity 12/2774 194/18639 0.0618556701030928 0.415619262815986 0.999952813233639 1 GO:0008528 G protein-coupled peptide receptor activity 5/2774 122/18639 0.040983606557377 0.275376150909499 0.999972133169579 1 GO:0001653 peptide receptor activity 5/2774 128/18639 0.0390625 0.262467893835616 0.999987327491829 1 GO:0005179 hormone activity 5/2774 132/18639 0.0378787878787879 0.254514321295143 0.999992541261863 1 GO:0005261 monoatomic cation channel activity 24/2774 341/18639 0.0703812316715543 0.472904029245169 0.999997615470059 1 GO:0008083 growth factor activity 6/2774 162/18639 0.037037037037037 0.248858447488584 0.999999264828756 1 GO:0030527 structural constituent of chromatin 1/2774 98/18639 0.0102040816326531 0.0685630416550182 0.999999867482239 1 GO:0003823 antigen binding 5/2774 174/18639 0.028735632183908 0.19307982994804 0.999999976221868 1 GO:0045182 translation regulator activity 9/2774 356/18639 0.0252808988764045 0.169866861628444 1 1 GO:0004984 olfactory receptor activity 1/2774 419/18639 0.00238663484486874 0.0160362245398372 1 1 GO:0030371 translation repressor activity 5/2774 329/18639 0.0151975683890578 0.102115168422367 1 1