category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	80/1220	222/9376	2.76945798257274	RPS10/RPS26/RPL6/RPS8/RACK1/RPS6/RPSA/RPS3A/RPL27A/RPS24/RPL19/RPS12/RPL5/RPL26/RPL14/RPL13/RPL13A/RPL36AL/RPS27A/RPL10/RPL36A/RPL17/MRPS34/MRPL2/RPL7A/MRPS15/MRPL12/RPS15/RPL3/RPL41/RPL8/RPS3/RPL32/RPS4X/MRPL16/RPL12/MRPL34/RPL10A/RPL30/MRPL14/MRPS33/RPL15/MRPS18B/MRPL36/MRPS24/RPS5/MRPL15/MRPS7/RPL22/RPL22L1/RPS9/MRPL52/RPS15A/RPL21/RPS25/MRPL28/RPL24/MRPS12/MRPL48/RPL11/RPS7/RPS13/MRPL10/RPS16/RPS23/MRPL18/RPS19/RPS18/RPL9/RPL31/RPL35A/MRPL46/FAU/UBA52/RPS2/RPL28/RPLP1/RPL23A/RPS20/RPS10-NUDT3	10.3190147333323
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	80/1220	268/9376	2.2941032542207	MT-ATP8/MT-ND2/MT-ND1/BAX/MT-ND4/MT-CYB/MT-ATP6/NDUFB7/COX4I1/MT-ND6/NDUFS3/RPS27A/CYCS/PSMD4/NDUFB11/SLC25A6/UQCRH/PSMC3/NDUFB9/MT-ND5/PARK7/COX6B1/ATP5MC3/COX7A1/PSMC5/ATP5PD/PSMD7/NDUFB5/COX8A/NDUFS7/NDUFS8/SLC25A5/PSMD8/PSMB6/NDUFS2/PSMD13/COX6A1/NDUFA11/NDUFV3/PSMD2/SLC39A4/VDAC1/ATF4/SLC39A3/COX5A/SLC39A1/ATP5MC1/PSMD12/ATP5PO/UQCRFS1/NDUFA3/HSPA5/VDAC2/ATP5F1D/XBP1/NDUFB10/NDUFB2/UBE2G2/PSMA5/NDUFS6/PINK1/NDUFA6/PSMC6/ITPR3/TUBA1A/NDUFA13/UBA52/MAP3K5/COX5B/TH/ATP5MC2/TUBB2A/UQCR11/SOD1/GNAL/NDUFA4/TUBA1B/BCL2L1/CAMK2G/SLC25A4	8.3128847664262
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	71/1220	227/9376	2.40375532606341	MT-ATP8/MT-ND2/MT-ND1/EPHX1/MT-ND4/GSTM5/MT-CYB/MAP2K2/MT-ATP6/NDUFB7/GSTM3/COX4I1/CYP1B1/MT-ND6/NDUFS3/BAD/NDUFB11/SLC25A6/UQCRH/AKR1A1/NDUFB9/MT-ND5/COX6B1/ATP5MC3/COX7A1/JUN/CYBA/ATP5PD/NDUFB5/COX8A/CBR1/NDUFS7/NDUFS8/SLC25A5/NDUFS2/COX6A1/NDUFA11/NDUFV3/VDAC1/COX5A/ATP5MC1/HGF/GSTM1/ATP5PO/UQCRFS1/NDUFA3/ACP1/VDAC2/ATP5F1D/NDUFB10/NDUFB2/HRAS/GSTO1/NDUFS6/NDUFA6/NDUFA13/MAP3K5/COX5B/GSTM4/ATP5MC2/UQCR11/SOD1/GSTM2/NDUFA4/VEGFA/PLD1/SLC25A4/PLD2/MGST2/AS3MT/SLC26A6	8.28026959018396
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	73/1220	238/9376	2.35723928915829	RPS10/RPS26/RPL6/RPS8/RPS6/RPSA/RPS3A/RPL27A/RPS24/RPL19/RPS12/NFKBIB/RPL5/RPL26/PLCG2/RPL14/RPL13/RPL13A/RPL36AL/RPS27A/RPL10/RPL36A/RPL17/RPL7A/RPS15/RPL3/C2/RPL41/RPL8/RPS3/RPL32/RPS4X/RPL12/RPL10A/RPL30/JUN/RPL15/RPS5/RPL22/RPL22L1/RPS9/IRF3/RPS15A/RPL21/TLR4/RPS25/RPL24/RPL11/RPS7/RPS13/CGAS/RPS16/IFNAR2/RPS23/RPS19/RPS18/IRAK1/RPL9/RPL31/RPL35A/FAU/UBA52/RPS2/RPL28/RPLP1/RPL23A/RPS20/C6/C3/CFD/C5AR1/RPS10-NUDT3/IKBKE	8.20250057871051
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	84/1220	308/9376	2.09597615499255	MT-ATP8/GRIA4/MT-ND2/MT-ND1/BAX/MT-ND4/MT-CYB/MT-ATP6/NDUFB7/COX4I1/MT-ND6/NDUFS3/CYCS/PSMD4/NDUFB11/SLC25A6/UQCRH/PSMC3/GPX7/NDUFB9/MT-ND5/NRBF2/COX6B1/ATP5MC3/COX7A1/POLR2F/PSMC5/ATP5PD/PSMD7/NDUFB5/COX8A/NDUFS7/NDUFS8/SLC25A5/PSMD8/PSMB6/NDUFS2/PSMD13/COX6A1/TFAM/NDUFA11/NDUFV3/PSMD2/POLR2C/VDAC1/COX5A/ATP5MC1/POLR2E/PSMD12/ATP5PO/UQCRFS1/NDUFA3/VDAC2/ATP5F1D/ATG101/NDUFB10/CLTA/NDUFB2/PSMA5/NDUFS6/POLR2I/NDUFA6/PSMC6/CREB3/TUBA1A/AP2S1/NDUFA13/MAP3K5/COX5B/HAP1/DLG4/ATP5MC2/TUBB2A/UQCR11/SOD1/POLR2L/MAP3K10/NDUFA4/TUBA1B/DNAH1/TRAF2/SLC25A4/GPX3/PLCB2	7.56393264445427
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	114/1220	480/9376	1.82524590163934	MT-ATP8/GRIA4/MT-ND2/MT-ND1/BAX/WNT2/MT-ND4/MT-CYB/MAP2K2/MT-ATP6/NDUFB7/COX4I1/MT-ND6/NDUFS3/BAD/RPS27A/TOMM40/CYCS/PSMD4/NDUFB11/SLC25A6/UQCRH/PSMC3/GPX7/NDUFB9/MT-ND5/NRBF2/PARK7/COX6B1/NEFM/ATP5MC3/SIGMAR1/COX7A1/PSMC5/ATP5PD/PSMD7/NDUFB5/COX8A/NDUFS7/NDUFS8/SLC25A5/PSMD8/PSMB6/NDUFS2/WNT5B/PSMD13/COX6A1/NDUFA11/NDUFV3/PSMD2/WNT5A/FAS/VDAC1/ATF4/COX5A/ATP5MC1/PSMD12/ATP5PO/UQCRFS1/NDUFA3/HSPA5/LRP5/VDAC2/ATP5F1D/ATG101/XBP1/NDUFB10/NDUFB2/UBE2G2/HRAS/PSMA5/NDUFS6/PINK1/NDUFA6/PSMC6/NEFH/ITPR3/TUBA1A/NDUFA13/BAK1/BID/UBA52/MAP3K5/COX5B/HAP1/DLG4/FRAT2/ATP5MC2/TUBB2A/UQCR11/SOD1/BCL2/MAP3K10/NDUFA4/TUBA1B/DNAH1/BCL2L1/SQSTM1/WNT2B/AGER/CAMK2G/FZD10/ATP2A1/SPTBN2/TRAF2/MAP2K3/PSEN2/WNT9B/SLC25A4/GPX3/PLCB2/FZD4/TOMM40L/MAP1LC3B2	7.1784974881702
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	48/1220	138/9376	2.67312900926586	MT-ATP8/MT-ND2/MT-ND1/MT-ND4/MT-CYB/MT-ATP6/NDUFB7/COX4I1/MT-ND6/NDUFS3/CYCS/NDUFB11/UQCRH/ATP6V0D1/NDUFB9/MT-ND5/ATP6V0C/COX6B1/ATP5MC3/COX7A1/ATP5PD/NDUFB5/COX8A/NDUFS7/NDUFS8/NDUFS2/COX6A1/NDUFA11/NDUFV3/COX5A/ATP5MC1/ATP5PO/UQCRFS1/NDUFA3/ATP5F1D/NDUFB10/NDUFB2/ATP6V1F/NDUFS6/NDUFA6/COX10/NDUFA13/COX5B/ATP6V1E2/ATP5MC2/UQCR11/ATP6V1G2/NDUFA4	7.65785146708361
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	93/1220	368/9376	1.94219529579473	MT-ATP8/MT-ND2/MT-ND1/BAX/MT-ND4/MT-CYB/MT-ATP6/HNRNPA1/NDUFB7/COX4I1/MT-ND6/NDUFS3/BAD/TOMM40/CYCS/PSMD4/NDUFB11/UQCRH/PSMC3/GPX7/NDUFB9/MT-ND5/NRBF2/CHCHD10/COX6B1/NEFM/ATP5MC3/SIGMAR1/COX7A1/PSMC5/ATP5PD/PSMD7/NDUFB5/COX8A/NDUFS7/NDUFS8/PSMD8/PSMB6/NDUFS2/PSMD13/COX6A1/NDUFA11/NDUFV3/PSMD2/VDAC1/ATF4/COX5A/ATP5MC1/PSMD12/ATP5PO/UQCRFS1/NDUFA3/HSPA5/ATP5F1D/ATG101/XBP1/NDUFB10/ANXA11/NDUFB2/PSMA5/NDUFS6/PINK1/NDUFA6/PSMC6/NEFH/ITPR3/TUBA1A/SRSF3/NDUFA13/BID/MAP3K5/COX5B/HAP1/TPR/ATP5MC2/TUBB2A/UQCR11/SOD1/UBQLN4/BCL2/NDUFA4/TUBA1B/DNAH1/BCL2L1/SQSTM1/NRG2/HNRNPA1L2/NUP210L/TRAF2/MAP2K3/GPX3/TOMM40L/MAP1LC3B2	7.13144598502594
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	61/1220	205/9376	2.28682926829268	MT-ATP8/MT-ND2/MT-ND1/MT-ND4/MT-CYB/MT-ATP6/GAPDH/NDUFB7/COX4I1/MT-ND6/NDUFS3/NDUFB11/SLC25A6/UQCRH/PARP1/NDUFB9/MT-ND5/COX6B1/ATP5MC3/COX7A1/CYBA/ATP5PD/PDHA1/NDUFB5/COX8A/NDUFS7/NDUFS8/SLC25A5/CTSD/NDUFS2/IRS1/COX6A1/NDUFA11/NDUFV3/VDAC1/COX5A/ATP5MC1/ATP5PO/UQCRFS1/NDUFA3/VDAC2/ATP5F1D/TGFB2/NDUFB10/NDUFB2/NDUFS6/NDUFA6/PDK3/NDUFA13/COX5B/TBC1D4/PRKCZ/ATP5MC2/UQCR11/NDUFA4/TGFB3/AGER/CAMK2G/ATP2A1/SLC25A4/PLCB2	7.20470924390457
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	94/1220	388/9376	1.86188947101572	MT-ATP8/MT-ND2/MT-ND1/WNT2/MT-ND4/MT-CYB/MAP2K2/MT-ATP6/GAPDH/NDUFB7/COX4I1/MT-ND6/NDUFS3/BAD/CYCS/PSMD4/NDUFB11/SLC25A6/UQCRH/PSMC3/NDUFB9/MT-ND5/NRBF2/COX6B1/ATP5MC3/COX7A1/PSMC5/ATP5PD/PSENEN/PSMD7/NDUFB5/COX8A/NDUFS7/NDUFS8/SLC25A5/PSMD8/PSMB6/NDUFS2/IRS1/WNT5B/PSMD13/COX6A1/NDUFA11/NDUFV3/PSMD2/SLC39A4/WNT5A/FAS/VDAC1/ATF4/SLC39A3/COX5A/SLC39A1/ATP5MC1/PSMD12/ATP5PO/UQCRFS1/NDUFA3/LRP5/VDAC2/ATP5F1D/ATG101/XBP1/NDUFB10/NDUFB2/HRAS/PSMA5/NDUFS6/NDUFA6/PSMC6/ITPR3/TUBA1A/NDUFA13/BID/MAP3K5/COX5B/BACE2/FRAT2/ATP5MC2/TUBB2A/UQCR11/NDUFA4/TUBA1B/WNT2B/AGER/FZD10/ATP2A1/TRAF2/PSEN2/WNT9B/SLC25A4/LPL/PLCB2/FZD4	6.70598922434694
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	73/1220	275/9376	2.04008345752608	MT-ATP8/MT-ND2/MT-ND1/BAX/MT-ND4/MT-CYB/MT-ATP6/NDUFB7/COX4I1/MT-ND6/NDUFS3/BAD/CYCS/PSMD4/NDUFB11/SLC25A6/UQCRH/PSMC3/NDUFB9/MT-ND5/COX6B1/ATP5MC3/COX7A1/PSMC5/CYBA/ATP5PD/PSMD7/NDUFB5/COX8A/NDUFS7/NDUFS8/SLC25A5/PSMD8/PSMB6/NDUFS2/PSMD13/COX6A1/NDUFA11/NDUFV3/PSMD2/VDAC1/ATF4/COX5A/ATP5MC1/HSPA8/PSMD12/ATP5PO/UQCRFS1/NDUFA3/HSPA5/VDAC2/ATP5F1D/NDUFB10/NDUFB2/PSMA5/NDUFS6/NDUFA6/PSMC6/CREB3/ITPR3/TUBA1A/NDUFA13/NCAM2/COX5B/ATP5MC2/TUBB2A/UQCR11/SOD1/NOTCH1/NDUFA4/TUBA1B/C6/SLC25A4	6.77044046789501
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	64/1220	235/9376	2.09300313916986	MT-ATP8/MT-ND2/MT-ND1/MGLL/RPS6/MT-ND4/MT-CYB/MT-ATP6/NDUFB7/COX4I1/MT-ND6/RPS6KB2/NDUFS3/NDUFB11/UQCRH/SMARCB1/NDUFB9/MT-ND5/COX6B1/ATP5MC3/NDUFAF8/COX7A1/SMARCD3/ATP5PD/NDUFB5/COX8A/NDUFS7/NDUFS8/NDUFS2/COX6A1/NDUFA11/NDUFV3/COA6/COX5A/ATP5MC1/NDUFAF3/ATP5PO/UQCRFS1/COX14/NDUFA3/FGFR1/ATP5F1D/NDUFB10/NDUFB2/HRAS/NDUFS6/NDUFAF5/NDUFA6/NDUFAF1/CREB3/COX10/NDUFA13/MLST8/MAP3K5/COX5B/ATP5MC2/UQCR11/PRKAG2/NDUFA4/DPF1/ADCY2/MAP2K3/RPS6KA2/PRKAA2	6.56274350621838
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	43/1220	157/9376	2.10487626605409	BAX/MT-CYB/NDUFB7/COX4I1/NDUFS3/CYCS/NDUFB11/UQCRH/NDUFB9/COX6B1/COX7A1/JUN/NDUFB5/COX8A/NDUFS7/NDUFS8/NDUFS2/IRS1/COX6A1/NDUFA11/NDUFV3/FAS/ATF4/COX5A/UQCRFS1/NDUFA3/XBP1/NR1H3/NDUFB10/NDUFB2/NDUFS6/NDUFA6/NDUFA13/SOCS3/BID/MAP3K5/COX5B/UQCR11/PRKAG2/NDUFA4/BCL2L11/TRAF2/PRKAA2	5.39943737317289
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	19/1220	59/9376	2.47490969713809	GSTM5/GSTM3/SRM/GPX7/GSTK1/GPX4/GSTP1/GGCT/GSTM1/GSTO1/GSS/GCLC/PRDX6/GSTM4/GGT5/GSTM2/MGST2/GPX3/OPLAH	4.39521712348169
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	22/1220	75/9376	2.25433879781421	BAX/GSTM5/GSTM3/BAD/CYCS/ERCC1/XPA/GSTP1/FAS/GSTM1/GSTO1/MLH1/BAK1/BID/MAP3K5/PMAIP1/GSTM4/GSTM2/BCL2/BCL2L1/CDKN2A/MGST2	4.21801004915254
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	39/1220	174/9376	1.72255511588468	ERP29/BAX/SSR2/BAG1/HSP90AB1/UBXN1/DAD1/UFD1/BCAP31/ERLEC1/STUB1/BAG2/PDIA6/DNAJB11/DNAJB12/UBXN6/ATF4/RAD23A/KRTCAP2/HSPA8/SSR4/SSR3/HSPA5/DDOST/XBP1/UBE2G2/HSPBP1/BAK1/MAP3K5/OSTC/NGLY1/PPP1R15A/DNAJC5/UBE2D4/UBQLN4/BCL2/DNAJB1/TRAM1L1/TRAF2	3.72075809217349
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	18/1220	63/9376	2.19578454332553	ERCC1/XPA/POLD2/POLE4/XPC/POLR2F/POLR2C/RAD23A/ERCC5/POLR2E/POLE3/POLR2I/RFC2/POLR2L/RFC3/RFC4/DDB2/POLD1	3.68303082494797
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	31/1220	137/9376	1.7389972478162	CTSH/BAX/CTSF/MAP2K2/GADD45A/BAD/CYCS/CTSZ/RIPK1/PARP1/JUN/CTSD/FAS/ATF4/NTRK1/HRAS/CASP10/TRADD/ITPR3/TUBA1A/BAK1/BID/MAP3K5/PMAIP1/BCL2/TUBA1B/BCL2L11/DFFB/BCL2L1/TRAF2/DIABLO	3.3699042863137
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	33/1220	149/9376	1.70210144130267	GRIA4/MT-ND2/MT-ND1/MGLL/MT-ND4/NDUFB7/MT-ND6/NDUFS3/NDUFB11/NDUFB9/MT-ND5/NDUFB5/NDUFS7/NDUFS8/NDUFS2/NDUFA11/NDUFV3/GNG4/NDUFA3/NDUFB10/NDUFB2/NDUFS6/NDUFA6/ITPR3/NDUFA13/GNAO1/GABRE/NDUFA4/ADCY2/GNG7/PLCB2/GABRP/FAAH	3.34110160846757
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	11/1220	32/9376	2.64180327868852	BAX/NGFR/CYCS/BOK/BAK1/BID/PMAIP1/BCL2/BCL2L11/BCL2L1/DIABLO	3.59796254397809
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	36/1220	170/9376	1.62746383799421	BAX/WNT2/IGF2/GSTM5/MAP2K2/GSTM3/PLCG2/GADD45A/RPS6KB2/BAD/SMARCB1/SMARCD3/GSTP1/WNT5B/WNT5A/HGF/GSTM1/LRP5/TGFB2/HRAS/GSTO1/BAK1/GSTM4/FRAT2/GSTM2/SHC3/TGFB3/BCL2L1/WNT2B/DDB2/DPF1/FZD10/CDKN2A/WNT9B/MGST2/FZD4	3.19304193301327
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	25/1220	110/9376	1.74664679582712	RPS6/EGLN3/MAP2K2/GAPDH/LDHA/PLCG2/RPS6KB2/LTBR/PDHA1/TIMP1/EIF4EBP1/LDHB/TLR4/ALDOA/ANGPT1/PFKFB3/ENO1/BCL2/ELOB/TEK/EPAS1/CAMK2G/VEGFA/PDK1/ENO2	3.04643800968849
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	14/1220	52/9376	2.06910466582598	LRPAP1/PLTP/VDAC1/VDAC2/LDLR/ANGPTL4/SCARB1/LCAT/CIDEB/NPC2/LDLRAP1/LPL/LIPC/NCEH1	2.98983835758344
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	23/1220	104/9376	1.69962168978562	PEMT/CHKB/GDPD5/ADPRM/PLA2G4C/LPIN3/AGPAT2/PLPP4/LPIN2/PTDSS2/PGS1/DGKA/PNPLA6/GPAT2/LCAT/PLPP1/LPCAT2/PLD1/PLD2/PLPP2/PLA2G2A/CDS1/PLA2G4B	2.77472641265128
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	31/1220	154/9376	1.54703001916117	NME1/AKR1A1/PPCS/MTHFD1L/MOCS2/GUSB/COQ4/ADSL/VKORC1/HMBS/AK6/COQ5/NME4/DHRS3/PMM1/NME6/UROS/GSS/GCLC/COX10/RFK/COQ7/RDH13/ALDH1B1/MTHFD2L/UGT2B7/ALDH3A2/NMNAT1/PHOSPHO2/PANK1/LIPT2	2.64719483056486
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	10/1220	34/9376	2.26036644165863	POLR1E/POLR2F/POLR2C/POLR2E/POLR3GL/POLR2I/POLR3D/POLR3K/POLR2L/POLR3G	2.84736605466704
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	29/1220	144/9376	1.54772313296903	KCND3/CYCS/NOP56/PSMD4/SLC25A6/PSMC3/NRBF2/PSMC5/PSMD7/SLC25A5/PSMD8/PSMB6/PSMD13/PSMD2/VDAC1/PSMD12/VDAC2/ATG101/XBP1/PSMA5/PSMC6/ITPR3/MAP3K5/TWNK/ATP2A1/SPTBN2/TRAF2/SLC25A4/PLCB2	2.56165935058874
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	18/1220	80/9376	1.72918032786885	BAX/RPS6/MAP2K2/PLCG2/RPS6KB2/BAD/GAS6/EIF4EBP1/HGF/HRAS/SHC3/BCL2/PDGFC/BCL2L11/BCL2L1/VEGFA/NRG2/KDR	2.5331378520841
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	10/1220	36/9376	2.13479052823315	RNASEH2C/POLD2/POLE4/POLE3/RFC2/RFC3/RFC4/RNASEH2A/DNA2/POLD1	2.6382774135683
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	9/1220	31/9376	2.23120042305658	GET3/SRPRB/UBL4A/SEC11C/SGTA/SRPRA/OXA1L/HSPA5/BAG6	2.65550360353956
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	6/1220	17/9376	2.71243972999036	CA4/CA8/CA13/CA3/CA1/CA12	2.73307769157061
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	45/1220	253/9376	1.36694097064731	BAX/NFKBIB/ACTN1/PLCG2/RPS6KB2/RPS27A/CYCS/RIPK1/ARPC5L/ARPC5/JUN/TLN1/SHARPIN/PLCD3/UBE2V2/VDAC1/U2AF1/IRF3/TLR4/TNIP1/ACTR3B/CGAS/TRADD/ARPC1B/ITPR3/PYCARD/UBA52/UBE2V1/ARPC3/NOD1/MYL5/CBX3/UBE2D4/CYTH2/BCL2/MYL12A/VCL/BCL2L1/SQSTM1/C3/PRKCE/TRAF2/TECPR1/PLCB2/MAP1LC3B2	2.28830849884537
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	13/1220	54/9376	1.8501517911354	LDHA/SRM/BHMT2/CISD1/MDH2/CDO1/LDHB/GSS/GCLC/MRI1/TST/PHGDH/BHMT	2.42306882334277
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	11/1220	44/9376	1.92131147540984	TDG/PARP1/POLD2/POLE4/NTHL1/POLE3/RFC2/NEIL1/RFC3/RFC4/POLD1	2.36904002784803
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	37/1220	205/9376	1.38709316273491	BAX/NFKBIB/PLCG2/GADD45A/CYCS/PSMD4/RIPK1/PSMC3/JUN/PSMC5/PSMD7/PSMD8/PSMD13/SNW1/PSMD2/FAS/TAPBPL/IRF3/PSMD12/TRADD/VIM/PSMC6/IFNAR2/RELB/IRAK1/BAK1/BID/NFKB2/BCL2/BCL2L11/DDB2/HLA-DMB/CDK2/TRAF2/MAP2K3/NFKBIE/IKBKE	2.16726006823627
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	15/1220	67/9376	1.72057744066552	GAPDH/LDHA/AKR1A1/TPI1/PGAM1/PGM2/PDHA1/LDHB/ALDOA/ADH1C/G6PC3/ALDH1B1/ENO1/ALDH3A2/ENO2	2.28925142182781
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	41/1220	233/9376	1.35233940758461	CSRP1/LMOD1/FHL3/TPM1/TPM4/PDLIM4/FHL2/FMNL2/TLN1/ZYX/PDLIM2/SSPN/SYNPO2/TPM2/PDLIM7/CAPZB/VIM/TMOD1/ITGA6/SDC4/FBLN1/THBS1/MYL5/ENO1/ITGB3/COL27A1/BGN/VCL/DTNA/COL6A6/COL4A4/NID2/ANK3/MYH11/SPTBN2/DES/LAMA1/ITGA2/COL24A1/ENO2/ACTN2	2.10630745751256
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	9/1220	34/9376	2.03432979749277	DBP/NPAS2/NR1D1/NFIL3/PER3/BHLHE41/PRKAG2/PER2/PRKAA2	2.33671371861964
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	11/1220	45/9376	1.87861566484517	ABCA8/ABCB8/ABCA6/ABCC10/DEFB1/ABCB6/ABCC3/ABCC1/ABCA9/ABCA13/ABCB9	2.28490448004765
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	7/1220	24/9376	2.24153005464481	B3GAT3/B4GALT7/B3GALT6/NDST1/HS3ST3B1/XYLT2/HS6ST2	2.35525293721701
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	14/1220	63/9376	1.70783242258652	BAX/WNT2/GADD45A/WNT5B/WNT5A/GLI1/BMP4/BAK1/GLI2/WNT2B/DDB2/FZD10/WNT9B/FZD4	2.18013240414838
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	18/1220	87/9376	1.59005087620124	BAX/MAP2K2/GADD45A/RPS6KB2/BAD/CYCS/JUN/RALB/TGFB2/HRAS/MLH1/BAK1/PMAIP1/RAC3/BCL2/TGFB3/BCL2L11/DDB2	2.13841282033721
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	16/1220	75/9376	1.63951912568306	BAX/GADD45A/CYCS/FAS/CHEK2/ZNF385A/BID/PMAIP1/GORAB/THBS1/BCL2/BCL2L1/DDB2/CDKN2A/CDK2/PPP1R13L	2.15053389359957
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	11/1220	46/9376	1.83777619387028	PSMD4/PSMC3/PSMC5/PSMD7/PSMD8/PSMB6/PSMD13/PSMD2/PSMD12/PSMA5/PSMC6	2.20289123179737
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	15/1220	70/9376	1.64683840749415	EPHX1/GSTM5/GSTM3/CYP1B1/GSTK1/GSTP1/CBR1/GSTM1/GSTO1/GSTM4/HSD11B1L/GSTM2/UGT2B7/MGST2/SULT1A3	2.10082675688006
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	10/1220	41/9376	1.87445021991204	PGAM1/GCSH/GRHPR/GAMT/DMGDH/SRR/PHGDH/AMT/BHMT/PSPH	2.17018523052673
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	16/1220	77/9376	1.59693421332766	BAX/GADD45A/RPS6KB2/BAD/RALB/TGFB2/BAK1/RALBP1/RAC3/TGFB3/BCL2L1/DDB2/VEGFA/CDKN2A/PLD1/PLD2	2.03413913321535
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	14/1220	65/9376	1.65528373266078	MGLL/AKR1A1/LPIN3/AGPAT2/PLPP4/LPIN2/ALDH1B1/DGKA/ALDH3A2/GPAT2/PLPP1/LPL/LIPC/PLPP2	2.05028789101554
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	14/1220	65/9376	1.65528373266078	ATF4/LDLR/CREB3/CYP11A1/ITPR3/ORAI1/SCARB1/POMC/CACNA1H/ADCY2/KCNA4/PLCB2/KCNK3/NCEH1	2.05028789101554
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	8/1220	31/9376	1.98328926493919	PGP/GCSH/HYI/MDH2/GRHPR/MCEE/AMT/PCCB	2.12079864290931
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	28/1220	155/9376	1.38830248545743	WNT2/MAP2K2/WNT5B/AIP/WNT5A/ATF4/LDLR/CREB3/CYP11A1/ITPR3/ORAI1/SCARB1/POMC/RAP1B/WNT2B/CACNA1H/CAMK2G/FZD10/CDKN2A/CDK2/ADCY2/CDKN2B/WNT9B/KCNA4/PLCB2/FZD4/KCNK3/NCEH1	1.88527172221924
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	9/1220	37/9376	1.8693841382366	BAX/MAP2K2/GADD45A/NTRK1/HRAS/BAK1/TPR/RXRB/DDB2	2.0492235188687
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	7/1220	26/9376	2.06910466582598	SCARB1/SLC19A1/ABCC1/TCN2/MMACHC/SLC46A1/LRAT	2.11119349198664
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	16/1220	79/9376	1.5565054990662	VAMP2/ATP6V0D1/ATP6V0C/NSF/CLTA/ATP6V1F/DNM3/DNM1/AP2S1/ATP6V1E2/DNM2/ATP6V1G2/SLC1A1/RAB3A/SLC6A12/STX3	1.92104941040779
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	6/1220	21/9376	2.19578454332553	ENPP3/PPCS/CSAD/ALDH1B1/ALDH3A2/PANK1	2.12162015214036
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	20/1220	105/9376	1.46385636221702	FKBP8/RPS27A/TOMM40/PHB2/JUN/FIS1/CITED2/ATF4/HRAS/SAMM50/PINK1/RRAS/MRAS/GABARAPL2/UBA52/BCL2L1/SQSTM1/TRAF2/TOMM40L/MAP1LC3B2	1.84859520287866
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	28/1220	158/9376	1.36194231168292	WNT2/RPS6/MAP2K2/RPS6KB2/EIF4EBP1/IRS1/WNT5B/TBC1D7/LPIN3/WNT5A/LAMTOR4/LRP5/HRAS/ATP6V1F/LPIN2/MLST8/SLC3A2/ATP6V1E2/ATP6V1G2/NPRL2/DEPTOR/WNT2B/CASTOR2/FZD10/WNT9B/FZD4/RPS6KA2/PRKAA2	1.77450199694744
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	12/1220	56/9376	1.64683840749415	DAD1/ALG12/DPM2/SRD5A3/B4GALT2/DPM3/ALG3/KRTCAP2/ALG8/DDOST/OSTC/ALG6	1.87762475097817
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	17/1220	87/9376	1.50171471641229	MT-CYB/COX4I1/TPM1/UQCRH/TPM4/COX6B1/COX7A1/COX8A/COX6A1/COX5A/TPM2/UQCRFS1/CACNB2/COX5B/UQCR11/ATP2A1/CACNA2D3	1.81827233040488
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	22/1220	120/9376	1.40896174863388	BAX/MAP2K2/NFKBIB/PLCG2/NGFR/BAD/JUN/IRS1/ATF4/NTRK1/HRAS/IRAK1/MAP3K5/ZNF274/SHC3/BCL2/RAP1B/CAMK2G/SH2B2/PSEN2/NFKBIE/RPS6KA2	1.74376752018419
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	4/1220	12/9376	2.56174863387978	COQ4/VKORC1/COQ5/COQ7	2.09362068370808
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	11/1220	51/9376	1.65760205721633	PLA2G7/PLA2G4C/PAFAH1B3/PLPP1/LPCAT2/PLD1/PLD2/PLPP2/GDPD3/PLA2G2A/PLA2G4B	1.82117120922047
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	16/1220	82/9376	1.49956017592963	CES1/GSTM5/GSTM3/NME1/GUSB/GSTP1/GSTM1/NME4/GSTO1/NME6/IMPDH1/GSTM4/GSTM2/UGT2B7/UPP2/MGST2	1.75719657048983
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	16/1220	83/9376	1.48149318585819	NFKBIB/GSDME/RIPK1/POLR2F/IRF3/POLR2E/DNASE2/CGAS/POLR3GL/GSDMD/POLR3D/POLR3K/PYCARD/POLR2L/POLR3G/IKBKE	1.70403365501415
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	20/1220	109/9376	1.41013686268612	RPS6KB2/IRS1/NR1H3/PPP1R3B/CREB3/G6PC3/SOCS3/TBC1D4/PRKCZ/SLC27A5/PPARGC1B/PRKAG2/PPP1R3D/PPP1R3E/PRKCE/TRIB3/PYGM/RPS6KA2/PRKAA2/SLC27A6	1.66571009367157
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	6/1220	23/9376	2.00484675694939	POLD2/MLH1/RFC2/RFC3/RFC4/POLD1	1.86601543187494
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	26/1220	149/9376	1.34104962042029	MAP2K2/PLCG2/LPAR1/RALB/PLA2G4C/AGPAT2/HRAS/RRAS/MRAS/DNM3/DNM1/KITLG/CYTH2/DGKA/GRM7/DNM2/PIP5K1A/SHC3/PDGFC/PLPP1/PLD1/ADCY2/PLD2/PLCB2/PLPP2/PLA2G4B	1.62295840504087
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	34/1220	204/9376	1.28087431693989	WNT2/RPS6/IGF2/MAP2K2/PLCG2/RPS6KB2/TWIST1/TFAP4/WNT5B/WNT5A/FAS/HGF/TLR4/FGFR1/TGFB2/HRAS/CD63/RRAS/MRAS/ITPR3/PDCD4/SDC4/THBS1/ITGB3/WNT2B/CAMK2G/VEGFA/FZD10/ANK3/TIMP3/WNT9B/ITGA2/FZD4/KDR	1.56863548400353
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	26/1220	150/9376	1.33210928961749	BAX/FGF10/WNT2/MAP2K2/GADD45A/RPS6KB2/WNT5B/WNT5A/HGF/LRP5/TGFB2/HRAS/MLH1/BAK1/FRAT2/RXRB/SHC3/BCL2/TGFB3/WNT2B/DDB2/FZD10/CDK2/CDKN2B/WNT9B/FZD4	1.58579437506378
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	8/1220	35/9376	1.75662763466042	TPI1/ALDOA/PMM1/SORD/PFKFB3/KHK/TIGAR/PFKFB2	1.73438887962887
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	10/1220	47/9376	1.63515870247646	LDHA/AKR1A1/PDHA1/MDH2/GRHPR/LDHB/ADH1C/ALDH1B1/HAGH/ALDH3A2	1.68826485697222
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	16/1220	85/9376	1.44663452266152	ENPP3/DCTPP1/NME1/NT5C/ASMTL/HDDC2/APRT/ADSL/DTYMK/AK6/NME4/NME6/ENTPD2/IMPDH1/NT5M/UPP2	1.59976969918266
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	18/1220	98/9376	1.41157577785212	PLCG2/RPS6KB2/ARPC5L/ARPC5/PLA2G4C/ACTR3B/ARPC1B/GSN/LIMK2/ARPC3/DNM2/PIP5K1A/PLPP1/PRKCE/PLD1/PLD2/PLPP2/PLA2G4B	1.58402709647366
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	24/1220	138/9376	1.33656450463293	RPS6/MAP2K2/PRKAR2B/RPS6KB2/BAD/SOCS2/EIF4EBP1/SORBS1/IRS1/HRAS/PRKAR1B/PPP1R3B/G6PC3/SOCS3/PPP1R3F/PRKCZ/PRKAG2/SHC3/PPP1R3D/PPP1R3E/SH2B2/PYGM/PRKAA2/PHKA1	1.5404436665063
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	15/1220	79/9376	1.45922390537456	EPHX1/GSTM5/GSTM3/CYP1B1/GSTK1/GSTP1/CBR1/GSTM1/GSTO1/ADH1C/GSTM4/HSD11B1L/GSTM2/UGT2B7/MGST2	1.58523467269463
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	22/1220	125/9376	1.35260327868852	BAX/MAP2K2/ASAH1/DEGS1/CTSD/HRAS/TRADD/BID/MAP3K5/ORMDL2/PRKCZ/RAC3/BDKRB2/SMPD2/BCL2/ABCC1/PPP2R5B/PRKCE/PLD1/TRAF2/PLD2/PLCB2	1.53487833950373
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	7/1220	30/9376	1.79322404371585	GPAA1/DPM2/PIGQ/PIGC/PIGT/PIGZ/PIGA	1.68294744398126
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	18/1220	99/9376	1.3973174366617	MAP2K2/RPS6KB2/CHKB/JUN/EIF4EBP1/PLA2G4C/HRAS/RAC3/DGKA/SLC22A5/SLC22A3/PIP5K1A/PDGFC/PLPP1/PLD1/PLD2/PLPP2/PLA2G4B	1.5370160016257
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	9/1220	42/9376	1.64683840749415	SAT2/GPX4/VDAC2/GSS/GCLC/SLC3A2/FTH1/SLC7A11/MAP1LC3B2	1.62485080956608
NA	NA	hsa04519	Cadherin signaling	62/1220	404/9376	1.17941892549911	WNT2/MAP2K2/ACTN1/CDH3/LIMA1/ARPC5L/ARPC5/PSENEN/MYO1E/WNT5B/WNT5A/FGFR1/LRP5/KRT10/HRAS/ACTR3B/VIM/RRAS/MRAS/LHFPL2/ARPC1B/CIB2/SCN5A/AMOTL2/RAC3/ARPC3/PCDHGA10/PCDHGA5/TEAD4/PCDHGA3/PCDHGC3/CDH13/PCDHB4/GABRE/VCL/WNT2B/PCDHA10/PCDHGA8/PCDHGA7/FZD10/PCDHB15/PCDHB3/AFDN/PCDHGB6/PCDHGA2/PCDHGA9/PCDHB7/MAP2K3/PSEN2/PCDHB6/WNT9B/DES/PCDHGA6/PCDHB9/FZD4/GABRP/PCDHGB7/AJUBA/CDH26/PCDHGB5/KDR/PCDHB13	1.42574299520251
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	17/1220	93/9376	1.40482989599859	BAX/GADD45A/CYCS/LAMC3/ITGA6/BAK1/RXRB/BCL2/COL4A4/BCL2L1/DDB2/CDK2/TRAF2/CDKN2B/LAMA1/ITGA2/LAMB1	1.51738861408938
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	40/1220	250/9376	1.2296393442623	CTSH/CTSF/BORCS7/CTSZ/AP1S1/GNPTG/ATP6V0D1/ATP6V0C/KXD1/GUSB/CTSA/LAPTM4B/ACP2/ASAH1/CTSD/LAMTOR4/DNASE2/CLTA/ATP6V1F/SNAP29/CD63/AP2S1/MLST8/ATP6V1E2/CLN6/AGA/ROGDI/GPR155/GALNS/SLC29A3/AP4M1/ATP6V1G2/AP5S1/NAGPA/SLC36A1/DEPTOR/BORCS6/NPC2/FUCA1/ABCB9	1.4233215180946
NA	NA	hsa04518	Integrin signaling	26/1220	154/9376	1.29750904832872	FLNB/ACTN1/VEGFB/LAMC3/PARVB/TLN1/HGF/ITGA6/RAC3/THBS1/LIMS1/ICAM3/ITGB3/VCL/PDGFC/ICAM2/COL6A6/COL4A4/C3/VEGFA/MADCAM1/FREM2/LAMA1/ITGA2/LAMB1/KDR	1.43970968172777
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	47/1220	300/9376	1.2040218579235	FGF10/IGF2/MAP2K2/NGFR/GADD45A/VEGFB/CDC25B/JUN/PLA2G4C/FAS/ATF4/ECSIT/HGF/HSPA8/FGFR1/NTRK1/TGFB2/HRAS/CACNB2/TRADD/RRAS/MRAS/RELB/IRAK1/MAP3K5/KITLG/RAC3/ANGPT1/NFKB2/RPS6KA4/RAP1B/MAP3K10/IL1RAP/PDGFC/TGFB3/TEK/CACNA1H/VEGFA/ARRB2/RASGRP2/TRAF2/MAP2K3/CACNA2D3/RPS6KA2/JUND/KDR/PLA2G4B	1.38904727520824
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	28/1220	168/9376	1.28087431693989	BAX/HSP90AB1/SLC25A6/RIPK1/PARP1/SHARPIN/PPIA/SLC25A5/PLA2G4C/FAS/VDAC1/TLR4/VDAC2/TRADD/IFNAR2/PYCARD/BID/CHMP6/BCL2/SQSTM1/SPATA2L/FTH1/CAMK2G/TICAM1/PYGM/TRAF2/SLC25A4/PLA2G4B	1.42072806572318
NA	NA	hsa04981	Folate transport and metabolism	7/1220	31/9376	1.73537810682179	BHMT2/MTHFS/ABCC3/SLC19A1/BHMT/ABCC1/SLC46A1	1.58609368227906
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	22/1220	128/9376	1.32090163934426	PDE4D/ENPP3/NME1/ADPRM/PGM2/NT5C/GUCY1A1/HDDC2/APRT/ADSL/NUDT9/AK6/NME4/NME6/ENTPD2/IMPDH1/NT5M/PFAS/GUCY1B1/ADCY2/PDE4C/PDE3A	1.41377388436976
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	38/1220	238/9376	1.22705606832897	FGF10/IGF2/MAP2K2/PLCG2/NGFR/BAD/RASSF1/VEGFB/RALB/PLA2G4C/HGF/GNG4/FGFR1/NTRK1/HRAS/RRAS/MRAS/ETS2/RALBP1/RGL1/KITLG/RAC3/ANGPT1/SHC3/RAP1B/RIN1/PDGFC/BCL2L1/TEK/VEGFA/RASGRP2/PLD1/AFDN/PLD2/GNG7/PLA2G2A/KDR/PLA2G4B	1.3722175203336
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	8/1220	39/9376	1.57646069777217	MTHFD1L/GCSH/BHMT2/MTHFS/MTHFD2L/DMGDH/AMT/BHMT	1.39516403448645
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	27/1220	166/9376	1.25000987556785	MAP2K2/BAD/SLC25A6/ADRA2C/GUCY1A1/SLC25A5/IRS1/VDAC1/ATF4/EDNRB/VDAC2/CREB3/ITPR3/KCNMB3/KCNMA1/MYLK/BDKRB2/GUCY1B1/MEF2B/PRKCE/ATP2A1/ADCY2/ADRA1D/SLC25A4/PLCB2/ADRB1/PDE3A	1.25692202914031
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	10/1220	52/9376	1.47793190416141	CYP1B1/PLA2G4C/LDLR/CYP11A1/HSD17B1/SCARB1/ACOT2/ALOX5/ADCY2/PLA2G4B	1.33657553376283
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	19/1220	112/9376	1.30374707259953	NFKBIB/BAD/CYCS/LAMC3/HSPA8/TLR4/TGFB2/LDLR/IRAK1/ITGA6/GNAO1/BCL2/TGFB3/ALOX5/BCL2L1/HLA-DMB/MAP2K3/LAMA1/LAMB1	1.25068742764907
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	11/1220	59/9376	1.43284245623784	ENPP3/DCTPP1/NME1/NT5C/ASMTL/HDDC2/DTYMK/NME4/NME6/NT5M/UPP2	1.28986647732937
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	17/1220	99/9376	1.31968869018049	TPM1/TPM4/SSPN/TPM2/TGFB2/CACNB2/ITGA6/PRKAG2/ITGB3/TGFB3/DTNA/ATP2A1/DES/LAMA1/ITGA2/CACNA2D3/PRKAA2	1.23671046625764
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	35/1220	224/9376	1.20081967213115	BAX/MAP2K2/LTBR/SLC25A6/ANAPC13/FDPS/JUN/CD4/TLN1/SLC25A5/VDAC1/ATF4/CHEK2/VDAC2/TGFB2/HRAS/RAN/ETS2/RELB/CREB3/ANAPC15/VAC14/ANAPC11/MAD1L1/NFKB2/ANAPC2/TGFB3/BCL2L1/HLA-DMB/CDKN2A/CDK2/ADCY2/CDKN2B/SLC25A4/PTTG1	1.1765196961698
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	17/1220	101/9376	1.29355624086999	WNT2/MAP2K2/WNT5B/WNT5A/EDNRB/HRAS/CREB3/POMC/KITLG/GNAO1/WNT2B/CAMK2G/FZD10/ADCY2/WNT9B/PLCB2/FZD4	1.14715470432998
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	17/1220	101/9376	1.29355624086999	BAX/PLCG2/VEGFB/PIM1/JUN/PLCD3/TGFB2/HRAS/F3/PRKCZ/BCL2/TGFB3/COL4A4/PRKCE/AGER/VEGFA/PLCB2	1.14715470432998
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	19/1220	115/9376	1.26973627940128	PTH1R/PDE4D/NACA/WNK2/ATF4/FGFR1/LRP5/CREB3/ITPR3/RXRB/BCL2/RUNX2/ARRB2/PLD1/ADCY2/PLD2/PDE4C/PLCB2/JUND	1.12560570562235
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	7/1220	36/9376	1.49435336976321	ENPP3/PGM2/G6PC3/GBE1/PYGM/MGAM/GYG2	1.14932341900873
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	33/1220	216/9376	1.17413479052823	BAX/BAD/CYCS/HSP90AB1/JUN/CYBA/HSPD1/FAS/ATF4/IRF3/HSPA8/TLR4/HSPA5/XBP1/HRAS/LDLR/IRAK1/PYCARD/MIB2/BID/MAP3K5/RXRB/HSPA2/BCL2/RAP1B/BCL2L1/AGER/CAMK2G/TICAM1/TRAF2/MAP2K3/PLCB2/IKBKE	1.00136321031922
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	14/1220	83/9376	1.29630653762591	PMVK/GSTK1/PRDX5/ECH1/PHYH/PEX16/PEX10/SOD1/PEX11A/MPV17L/ACOX2/MPV17L2/PEX12/PECR	1.04864684931177
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	31/1220	203/9376	1.1736089800533	FLNB/ACTN1/BAD/VEGFB/LAMC3/PARVB/JUN/TLN1/ZYX/HGF/HRAS/ITGA6/MYLK/RAC3/THBS1/MYL5/ITGB3/PIP5K1A/SHC3/BCL2/RAP1B/MYL12A/VCL/PDGFC/COL6A6/COL4A4/VEGFA/LAMA1/ITGA2/LAMB1/KDR	0.96714469244986
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	12/1220	70/9376	1.31747072599532	EGLN3/MAP2K2/BAD/JUN/HGF/TGFB2/HRAS/RAP1B/TGFB3/ELOB/EPAS1/VEGFA	1.03109368270333
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	4/1220	18/9376	1.70783242258652	CD320/ZNF143/TCN2/MMACHC	1.16252453903581
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	17/1220	105/9376	1.24427790788447	PLCG2/GADD45A/LTBR/RIPK1/PARP1/TLR4/TRADD/RELB/IRAK1/NFKB2/BCL2/BCL2L1/CARD11/TICAM1/TRAF2/EDA2R/PPP1R13L	0.973514659853234
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	17/1220	105/9376	1.24427790788447	TPM1/TPM4/SSPN/TPM2/TGFB2/CACNB2/ITGA6/ITGB3/TGFB3/DTNA/ATP2A1/ADCY2/DES/LAMA1/ITGA2/CACNA2D3/ADRB1	0.973514659853234
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	8/1220	44/9376	1.3973174366617	DAD1/ALG12/B4GALT2/ALG3/KRTCAP2/DDOST/OSTC/B4GALNT3	1.02165330220686
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	37/1220	248/9376	1.14658910629297	BAX/MAP2K2/GAPDH/CYCS/HSP90AB1/RIPK1/ARPC5L/RPS3/ARPC5/JUN/DYNLRB1/STX10/TLR4/HRAS/ACTR3B/GSDMD/TRADD/RRAS/IRAK1/DYNLT3/ARPC1B/PYCARD/TUBA1A/BAK1/TUBB2A/ARPC3/NOD1/MYL5/CYTH2/ANXA2/DNM2/BCL2/MYL12A/TUBA1B/RHOJ/TRAF2/MAP2K3	0.904829323762728
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	32/1220	212/9376	1.16003711722858	FGF10/MAP2K2/NGFR/VEGFB/LPAR1/TLN1/RALB/HGF/FGFR1/P2RY1/HRAS/RRAS/MRAS/KITLG/PRKCZ/RAC3/GNAO1/ANGPT1/THBS1/ITGB3/RGS14/RAP1B/PDGFC/SIPA1L3/TEK/VEGFA/RASGRP2/AFDN/ADCY2/MAP2K3/PLCB2/KDR	0.911534383226052
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	13/1220	78/9376	1.28087431693989	C1D/EXOSC5/BTG2/BTG1/HSPD1/MPHOSPH6/EXOSC8/LSM4/EXOSC2/LSM3/EXOSC4/ENO1/ENO2	0.963366421336991
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	13/1220	78/9376	1.28087431693989	ARPC5L/ARPC5/MAD2L2/SEPTIN1/CLTA/ACTR3B/DNM3/DNM1/ARPC1B/ARPC3/DNM2/SHC3/VCL	0.963366421336991
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	23/1220	148/9376	1.19432875498449	BAX/FGF10/WNT2/MAP2K2/GADD45A/RPS6KB2/JUN/WNT5B/WNT5A/FGFR1/LRP5/HRAS/BAK1/FRAT2/NOTCH1/NFKB2/SHC3/NOTCH4/WNT2B/DDB2/FZD10/WNT9B/FZD4	0.921597054458471
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	21/1220	134/9376	1.20440420846587	MAP2K2/ACTA2/RAMP1/PPP1R14A/GUCY1A1/MYL6B/PLA2G4C/ITPR3/KCNMB3/KCNMA1/MYLK/EDN3/GUCY1B1/ADM/PRKCE/MYH11/ADCY2/ADRA1D/PLCB2/PLA2G2A/PLA2G4B	0.921692800792972
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	26/1220	170/9376	1.17539054966249	RAB13/ACTN1/ARPC5L/ARPC5/JUN/MYL6B/ACTR3B/ARPC1B/TUBA1A/MAP3K5/AMOTL2/PRKCZ/ARPC3/CLDN10/WHAMM/PRKAG2/EPB41L4B/MYL12A/CGNL1/TUBA1B/CLDN4/PRKCE/AFDN/MYH11/PRKAA2/CD1D	0.892528534420075
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	24/1220	156/9376	1.18234552332913	BAX/MAP2K2/BAD/CYCS/RIPK1/FAS/IRF3/NR1H3/HRAS/LDLR/TRADD/IFNAR2/EIF3E/BAK1/SOCS3/CD81/BID/SCARB1/CLDN10/CLDN4/CDK2/TICAM1/TRAF2/IKBKE	0.888216607718141
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	7/1220	38/9376	1.41570319240725	ENPP3/BST1/NT5C/NMRK1/NAMPT/NT5M/NMNAT1	0.993059266303897
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	22/1220	142/9376	1.19067190025398	GSTM5/GSTM3/HSP90AB1/JUN/CYBA/GSTP1/GSTM1/GSTO1/BMP4/MAP3K5/SDC4/GSTM4/PRKCZ/RAC3/GSTM2/ITGB3/BCL2/SQSTM1/VEGFA/MGST2/PRKAA2/KDR	0.885447623958004
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	4/1220	19/9376	1.61794650560828	GCSH/PDHA1/AMT/LIPT2	1.04276467734209
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	6/1220	32/9376	1.44098360655738	PGM2/B4GALT2/GALK1/G6PC3/GALE/MGAM	0.966402320848832
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	6/1220	32/9376	1.44098360655738	LDHA/LDHB/SUCLA2/MCEE/ACADS/PCCB	0.966402320848832
Human Diseases	Cancer: specific types	hsa05218	Melanoma	12/1220	73/9376	1.26332809342017	BAX/FGF10/MAP2K2/GADD45A/BAD/HGF/FGFR1/HRAS/BAK1/PDGFC/DDB2/CDKN2A	0.87352242630164
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	12/1220	73/9376	1.26332809342017	BAX/MAP2K2/PLCG2/GADD45A/BAD/RASSF1/HGF/HRAS/BAK1/RXRB/DDB2/CDKN2A	0.87352242630164
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	18/1220	116/9376	1.19253815715093	TKT/GAPDH/PGP/TPI1/PGAM1/GCSH/PDHA1/MDH2/SUCLA2/ALDOA/MCEE/ACADS/PHGDH/ENO1/AMT/PCCB/PSPH/ENO2	0.806988334858835
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	9/1220	53/9376	1.30504175688215	PTH1R/CLTA/DNM3/DNM1/AP2S1/BDKRB2/KLK1/DNM2/PLCB2	0.86128390444739
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	10/1220	60/9376	1.28087431693989	MAP2K2/PLCG2/BAD/PLA2G4C/HRAS/SH2D2A/RAC3/VEGFA/KDR/PLA2G4B	0.844111582530038
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	14/1220	88/9376	1.22265275707899	C2/CD59/CFI/CD55/F3/F2RL2/CLU/BDKRB2/C6/C3/CFD/C5AR1/SERPINF2/F8	0.811587323510453
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	6/1220	33/9376	1.3973174366617	VAMP2/VTI1B/SNAP29/VAMP5/STX8/STX3	0.884256712758086
NA	NA	hsa04517	IgSF CAM signaling	43/1220	299/9376	1.10523603267723	MAP2K2/ACTN1/PLCG2/PPFIA2/EPB41L3/ARPC5L/ARPC5/NRP2/SORBS1/MYL6B/CNTN1/FGFR1/ACTR3B/ARPC1B/TUBA1A/NCAM2/MYLK/TUBB2A/KCNQ3/ARPC3/CLMP/ICAM3/PVR/PLXNA2/PPFIA3/ITGB3/RAP1B/UNC5B/MYL12A/NLGN4X/TUBA1B/IL1RAP/VCL/ICAM2/NTN1/ANK3/AFDN/MYH11/SPTBN2/KCNA4/MPP3/GRIP1/KDR	0.715246660176004
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	9/1220	54/9376	1.28087431693989	ERCC1/CENPX/RAD51C/MLH1/CENPS/PALB2/FAAP100/FAAP24/EME2	0.800536807369208
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	25/1220	169/9376	1.13687069550878	MAP2K2/RPS6KB2/BAD/RPS27A/NRBF2/IGBP1/CTSD/IRS1/DAPK3/GORASP1/WDR45/ATG101/HRAS/SNAP29/RRAS/MRAS/MLST8/GABARAPL2/UBA52/BCL2/DEPTOR/BCL2L1/SQSTM1/PRKAA2/MAP1LC3B2	0.694419167541796
Organismal Systems	Immune system	hsa04611	Platelet activation	19/1220	126/9376	1.15888628675514	PLCG2/TLN1/GUCY1A1/PLA2G4C/P2RY1/ITPR3/ORAI1/MYLK/PRKCZ/ITGB3/GUCY1B1/RAP1B/MYL12A/RASGRP2/ADCY2/ITGA2/PLCB2/GP6/PLA2G4B	0.694428868217834
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	7/1220	41/9376	1.31211515393842	POLD2/RAD51C/XRCC3/RAD52/PALB2/XRCC2/POLD1	0.774598349770995
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	7/1220	41/9376	1.31211515393842	MAP2K2/RASSF1/DAPK3/HRAS/THBS1/VEGFA/CDKN2A	0.774598349770995
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	36/1220	250/9376	1.10667540983607	PSD/GRK5/ARPC5L/RAB11B/ARPC5/GRK4/VPS25/HSPA8/SNF8/CAPZB/WASHC3/CLTA/HRAS/ACTR3B/LDLR/DNM3/ARF5/DNM1/ARPC1B/AP2S1/SPART/PRKCZ/ACAP3/ARPC3/CYTH2/DNM2/ARF4/CHMP6/PIP5K1A/AGAP9/ARRB2/SNX32/PLD1/LDLRAP1/PLD2/RAB11FIP5	0.661182023311336
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	31/1220	214/9376	1.11328328481691	BAX/MAP2K2/PLCG2/RPS6KB2/BAD/CYCS/AP1S1/RIPK1/JUN/CD4/FAS/TAPBPL/IRF3/GNG4/TLR4/HRAS/CGAS/TRADD/IRAK1/ITPR3/BAK1/BID/RAC3/LIMK2/GNAO1/BCL2/ELOB/BCL2L1/TRAF2/MAP2K3/GNG7	0.648342545040907
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	4/1220	21/9376	1.46385636221702	B3GAT3/B4GALT7/B3GALT6/XYLT2	0.822996928059671
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	15/1220	98/9376	1.1763131482101	PLCG2/PLCD3/ITPR3/PIP4P1/ITPKA/IP6K3/IMPA2/INPP1/ITPK1/DGKA/PIP5K1A/MTMR8/SYNJ2/PLCB2/CDS1	0.678574443051226
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	15/1220	98/9376	1.1763131482101	ATF4/LDLR/CREB3/CYP11A1/ITPR3/ORAI1/SCARB1/POMC/CAMK1D/PRKCE/CACNA1H/CAMK2G/ADCY2/PLCB2/KCNK3	0.678574443051226
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	29/1220	200/9376	1.1143606557377	BAX/GAPDH/NFKBIB/CYCS/RIPK1/ARPC5L/LPAR1/RPS3/NCL/ARPC5/JUN/MYO1E/FAS/TLR4/ACTR3B/TRADD/IRAK1/ARPC1B/PYCARD/TUBA1A/BAK1/TUBB2A/ARPC3/CLDN10/CYTH2/TUBA1B/CLDN4/MYH11/TRAF2	0.632254424608862
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	5/1220	28/9376	1.37236533957845	HSD17B12/TECR/ACAA2/ACOT2/ELOVL2	0.763160454697462
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	5/1220	28/9376	1.37236533957845	ATP6V0D1/ATP6V0C/ATP6V1F/ATP6V1E2/ATP6V1G2	0.763160454697462
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	12/1220	77/9376	1.19770065999574	BAX/MAP2K2/GADD45A/BAD/TGFB2/HRAS/BAK1/SHC3/TGFB3/BCL2L1/DDB2/CDKN2A	0.673693415758534
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	11/1220	70/9376	1.20768149882904	NFKBIB/IRS1/TRADD/G6PC3/SOCS3/POMC/RXRB/PRKAG2/TRAF2/NFKBIE/PRKAA2	0.674515991311091
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	10/1220	63/9376	1.21988030184751	PTGES2/GPX4/CBR1/PLA2G4C/GGT5/ALOX5/PTGDS/PTGIS/PLA2G2A/PLA2G4B	0.67723398334879
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	27/1220	187/9376	1.10963443499605	NFKBIB/HSP90AB1/RIPK1/JUN/CYBA/SHARPIN/VDAC1/IRF3/TLR4/VDAC2/GSDMD/IFNAR2/ITPR3/PYCARD/GABARAPL2/NAMPT/CARD6/CARD9/CARD16/NOD1/BCL2/BCL2L1/TICAM1/TRAF2/PLCB2/MAP1LC3B2/IKBKE	0.58568028514522
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	12/1220	78/9376	1.18234552332913	PLCG2/TPI1/PLCD3/ITPKA/IP6K3/IMPA2/INPP1/ITPK1/PIP5K1A/MTMR8/SYNJ2/PLCB2	0.625424055037394
Human Diseases	Infectious disease: viral	hsa05162	Measles	20/1220	136/9376	1.13018322082932	BAX/RACK1/NFKBIB/BAD/CYCS/EIF3H/JUN/FAS/IRF3/HSPA8/TLR4/TRADD/IFNAR2/IRAK1/BAK1/BID/BCL2/BCL2L1/CDK2/IKBKE	0.591446444914294
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	31/1220	217/9376	1.09789227166276	FGF10/EPHX1/GSTM5/MAP2K2/GSTM3/CYP1B1/RPS6KB2/BAD/HSP90AB1/JUN/EIF4EBP1/AIP/ATF4/GSTM1/BCL6/HRAS/GSTO1/CREB3/GSTM4/CHRNA3/RXRB/GSTM2/UGT2B7/BCL2/VEGFA/ARRB2/ADCY2/MGST2/RPS6KA2/ADRB1/IKBKE	0.564262500584371
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	25/1220	173/9376	1.11058466786696	BAX/MAP2K2/NFKBIB/CYCS/SLC25A6/PABPN1/FDPS/RAB11B/SLC25A5/FAS/VDAC1/IRF3/TLR4/TRADD/IFNAR2/PYCARD/BAK1/SOCS3/BID/BCL2L2-PABPN1/DNAJB1/HLA-DMB/TICAM1/SLC25A4/IKBKE	0.567780147687916
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	21/1220	144/9376	1.1207650273224	RIPK1/C2/ACADVL/LPIN3/FAS/IRF3/TLR4/ADH1C/TRADD/LPIN2/IRAK1/MAP3K5/ALDH1B1/PRKAG2/ALDH3A2/C3/TICAM1/C5AR1/MAP2K3/PRKAA2/IKBKE	0.564808829211952
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	5/1220	29/9376	1.32504239683437	RASSF1/FRMD6/RASSF4/TEAD4/AJUBA	0.678000219344586
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	6/1220	36/9376	1.28087431693989	AKR1A1/GUSB/DCXR/SORD/UGT2B7/CRYL1	0.653005420822203
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	17/1220	116/9376	1.12628603730921	GRIA4/PLA2G4C/GNG4/HOMER1/SHANK2/ITPR3/DLG4/GNAO1/GRM7/SLC1A1/PLD1/ADCY2/PLD2/GNG7/PLCB2/DLGAP1/PLA2G4B	0.529304738718332
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	11/1220	73/9376	1.15805075230182	GSTM5/GSTM3/GSTK1/GSTP1/GSTM1/GSTO1/ADH1C/GSTM4/GSTM2/UGT2B7/MGST2	0.524292242564467
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	11/1220	73/9376	1.15805075230182	SMARCB1/CD4/PSIP1/PPIA/FEZ1/SUPT4H1/PIN1/ELL2/RAN/CHMP6/BICD1	0.524292242564467
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	20/1220	140/9376	1.09789227166276	RPS6/MAP2K2/ACTA2/RPS6KB2/TFAM/GNG4/HRAS/RRAS/MRAS/ITPR3/MYLK/PRKAG2/MEF2B/PRKCE/ADCY2/HDAC4/GNG7/PLCB2/PRKAA2/MAP1LC3B2	0.451333331069154
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	19/1220	133/9376	1.09789227166276	MAP2K2/GADD45A/IRS1/DEPP1/HOMER1/TGFB2/BCL6/HRAS/FBXO32/G6PC3/GABARAPL2/PRKAG2/PLK2/TGFB3/BCL2L11/CDK2/CDKN2B/PRKAA2/SGK2	0.439738707620411
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	13/1220	89/9376	1.12256400810462	MAP2K2/LPAR1/GUCY1A1/HRAS/ITPR3/TUBA1A/TUBB2A/GUCY1B1/TUBA1B/PDGFC/ADCY2/PLCB2/ADRB1	0.449311133791407
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	5/1220	31/9376	1.23955579058699	AKR1A1/GUSB/ALDH1B1/UGT2B7/ALDH3A2	0.516683761018563
Organismal Systems	Nervous system	hsa04730	Long-term depression	9/1220	60/9376	1.1527868852459	MAP2K2/GUCY1A1/PLA2G4C/HRAS/ITPR3/GNAO1/GUCY1B1/PLCB2/PLA2G4B	0.459170425049414
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	35/1220	254/9376	1.05899057699755	FGF10/PLCG2/VEGFB/SLC25A6/GNA14/SLC25A5/PLCD3/VDAC1/HGF/EDNRB/FGFR1/VDAC2/NTRK1/ITPR3/ORAI1/ITPKA/MYLK/ORAI2/BDKRB2/GNAL/PDGFC/CAMK1D/CACNA1H/PTGER3/CAMK2G/HRH2/VEGFA/ATP2A1/ADCY2/ADRA1D/SLC25A4/PLCB2/ADRB1/PHKA1/KDR	0.368622137792156
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	3/1220	17/9376	1.35621986499518	CYP39A1/SLC27A5/ACOX2	0.568531872545435
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	3/1220	17/9376	1.35621986499518	CSAD/CDO1/GGT5	0.568531872545435
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	7/1220	46/9376	1.16949394155381	GUSB/HMBS/UROS/COX10/HCCS/UGT2B7/FTH1	0.445675969815735
Human Diseases	Cancer: specific types	hsa05214	Glioma	11/1220	76/9376	1.11233822260569	BAX/MAP2K2/PLCG2/GADD45A/HRAS/BAK1/SHC3/CAMK1D/DDB2/CAMK2G/CDKN2A	0.380294299152125
Organismal Systems	Endocrine system	hsa04924	Renin secretion	10/1220	69/9376	1.11380375386077	GUCY1A1/ITPR3/ORAI1/KCNMA1/EDN3/GUCY1B1/PLCB2/PTGER2/ADRB1/PDE3A	0.366946898284924
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	15/1220	107/9376	1.07737092079056	LDHA/PGAM1/PDHA1/ATF4/LDHB/CREB3/ITPR3/G6PC3/PRKAG2/CAMK2G/ADCY2/PYGM/PLCB2/PRKAA2/PHKA1	0.311300743666559
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	3/1220	18/9376	1.28087431693989	MAN2C1/AGA/FUCA1	0.461300267419768
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	18/1220	130/9376	1.06411097099622	MAP2K2/ACTA2/VEGFB/JUN/ATF4/EDNRB/GNG4/HRAS/CREB3/PRKCZ/GNAO1/SHC3/COL4A4/VEGFA/ARRB2/ADCY2/GNG7/PLCB2	0.284678082011104
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	19/1220	138/9376	1.05811356616774	MAP2K2/ARPC5L/ARPC5/JUN/CD4/ARHGEF28/IRF3/TLR4/ACTR3B/IRAK1/ARPC1B/PYCARD/RAC3/ARPC3/PIP5K1A/TICAM1/TRAF2/MAP2K3/RPS6KA2	0.265983708052689
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	7/1220	48/9376	1.1207650273224	ACAA2/ACSF3/MCEE/ACADS/ALDH1B1/ALDH3A2/PCCB	0.324410183730404
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	13/1220	93/9376	1.07428168517539	MAP2K2/JUN/PLA2G4C/ATF4/HRAS/ITPR3/CAMK2G/PLD1/ADCY2/MAP2K3/PLD2/PLCB2/PLA2G4B	0.278423566131353
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	10/1220	71/9376	1.08242900023089	MAP2K2/LDHA/PGAM1/PDHA1/LDHB/FGFR1/NTRK1/HRAS/PDK1/TIGAR	0.269636054111767
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	8/1220	56/9376	1.09789227166276	BOC/GLI1/MGRN1/GAS1/BCL2/GLI2/ARRB2/CDON	0.28415899562233
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	8/1220	56/9376	1.09789227166276	EEF1G/CYCS/HSPD1/HSPA8/TLR4/PYCARD/NFKB2/C3	0.28415899562233
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	7/1220	49/9376	1.09789227166276	B4GALT2/XXYLT1/GALNT8/FUT10/C1GALT1C1L/GALNT10/B3GLCT	0.265706637440578
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	22/1220	163/9376	1.037272452982	BAX/MAP2K2/BAD/CYCS/JUN/FAS/ATF4/IRF3/TLR4/TGFB2/HRAS/CASP10/CREB3/IRAK1/BID/BCL2/TGFB3/DDB2/CDK2/TICAM1/MAP2K3/IKBKE	0.185655657122938
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	15/1220	110/9376	1.04798807749627	RPS6KB2/NBL1/TGFB2/FST/BMP4/EMP3/ID2/THBS1/SMAD6/ID4/LRRC32/BAMBI/TGFB3/CDKN2B/LEFTY2	0.19579900980433
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	31/1220	232/9376	1.02690785754664	FGF10/MAP2K2/ACTN1/ARPC5L/LPAR1/ARPC5/FGFR1/HRAS/ACTR3B/INSRR/RRAS/MRAS/ARPC1B/ITGA6/GSN/MYLK/RAC3/LIMK2/ARPC3/MYL5/BDKRB2/SSH1/ITGB3/PIP5K1A/MYL12A/VCL/PDGFC/C6/MYH11/ITGA2/RGCC	0.160502554381241
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	8/1220	57/9376	1.07863100373886	HSD17B12/ACADVL/TECR/ACAA2/ACSF3/ACADS/MCAT/ELOVL2	0.230289181657748
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	48/1220	362/9376	1.01903813060411	FGF10/RPS6/IGF2/MAP2K2/NGFR/RPS6KB2/BAD/VEGFB/HSP90AB1/LAMC3/LPAR1/EIF4EBP1/IRS1/ATF4/HGF/GNG4/CDC37/TLR4/FGFR1/NTRK1/HRAS/IFNAR2/CREB3/ITGA6/MLST8/G6PC3/KITLG/ANGPT1/THBS1/ITGB3/BCL2/PDGFC/BCL2L11/COL6A6/COL4A4/BCL2L1/PPP2R5B/TEK/VEGFA/CDK2/LAMA1/ITGA2/GNG7/LAMB1/PRKAA2/PRL/SGK2/KDR	0.142871878586001
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	13/1220	95/9376	1.05166522864538	ATP6V0D1/ATP6V0C/JUN/TLR4/TGFB2/ATP6V1F/ATP6V1E2/ANGPT1/ATP6V1G2/TGFB3/TEK/HLA-DMB/VEGFA	0.195744567085286
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	4/1220	27/9376	1.13855494839101	HSD17B12/TECR/ACOT2/ELOVL2	0.278835643077218
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	14/1220	103/9376	1.04459653031991	ACTN1/GNA14/LAMC3/TLR4/TGFB2/SERPINB6/GNAL/VCL/TGFB3/COL4A4/LAMA1/PLCB2/LAMB1/CD1D	0.176009657841593
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/1220	12/9376	1.28087431693989	NGFR/NCAM2	0.37652940217843
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	7/1220	50/9376	1.07593442622951	GYPC/HGF/TLR4/TGFB2/CD81/THBS1/TGFB3	0.208210658314867
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	44/1220	333/9376	1.01546792694334	BAX/WNT2/MAP2K2/RPS6KB2/BAD/LAMC3/ATP6V0D1/ATP6V0C/BCAP31/EIF4EBP1/WNT5B/WNT5A/FAS/TADA3/IRF3/HRAS/ATP6V1F/TRADD/IFNAR2/CREB3/ITGA6/BAK1/HES6/ATP6V1E2/PRKCZ/THBS1/NOTCH1/ATP6V1G2/ITGB3/COL6A6/COL4A4/PPP2R5B/NOTCH4/WNT2B/VEGFA/FZD10/CDK2/TICAM1/WNT9B/LAMA1/ITGA2/FZD4/LAMB1/IKBKE	0.111153952041348
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	21/1220	157/9376	1.02796282760781	MAP2K2/GADD45A/SLC25A6/EIF4EBP1/SLC25A5/VDAC1/CHEK2/VDAC2/TGFB2/HRAS/RRAS/MRAS/ITPR3/TGFB3/SQSTM1/CDKN2A/CDK2/MAP2K3/CDKN2B/SLC25A4/FOXM1	0.136651986366237
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	24/1220	180/9376	1.02469945355191	BAX/BAD/CYCS/EIF4EBP1/FAS/TAPBPL/IRF3/CGAS/TRADD/IFNAR2/IRAK1/SRSF3/BAK1/SOCS3/BID/CARD9/ITGB3/BCL2/BCL2L1/C3/HLA-DMB/TICAM1/TRAF2/IKBKE	0.129405001258795
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	6/1220	43/9376	1.072359893252	ACADVL/ACAA2/ADH1C/ACADS/ALDH1B1/ALDH3A2	0.183928257887312
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	12/1220	89/9376	1.03621293055811	LAMC3/ITGA6/SDC4/THBS1/ITGB3/COL6A6/COL4A4/FREM2/LAMA1/ITGA2/LAMB1/GP6	0.132754086118711
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	9/1220	66/9376	1.04798807749627	CYP1B1/HSD17B12/SRD5A3/HSD11B2/CYP11A1/HSD17B1/HSD11B1L/UGT2B7/DHRS11	0.151306443713708
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	13/1220	97/9376	1.02998140949806	GRIA4/GUCY1A1/GNG4/ITPR3/GNAO1/PER3/GUCY1B1/CACNA1H/CAMK2G/PER2/ADCY2/GNG7/PLCB2	0.114792700020476
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	7/1220	51/9376	1.05483767277403	PLCG2/ATP6V0D1/ATP6V0C/KDELR3/ATP6V1F/ATP6V1E2/ATP6V1G2	0.151868124104513
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	4/1220	28/9376	1.09789227166276	B4GALT2/A4GALT/B3GALNT1/B3GNT2	0.200629603813547
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	8/1220	59/9376	1.04206724090025	BAX/MAP2K2/GADD45A/BAD/HRAS/MLH1/BAK1/DDB2	0.125359985022254
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	5/1220	36/9376	1.06739526411658	ST6GALNAC4/GALNT8/C1GALT1C1L/GALNT10/ST6GALNAC2	0.156687422635678
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	10/1220	75/9376	1.02469945355191	TKT/GAPDH/TPI1/PGAM1/PYCR1/ALDOA/PHGDH/ENO1/PSPH/ENO2	0.0830577380466034
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	14/1220	106/9376	1.01503247757501	MAP2K2/BAD/HSP90AB1/GSTP1/ATF4/FGFR1/HRAS/INSRR/CREB3/SLC19A1/BCL2/PDGFC/CDK2/SLC46A1	0.0601964077360098
Human Diseases	Substance dependence	hsa05032	Morphine addiction	12/1220	91/9376	1.0134390199964	PDE4D/GRK5/GRK4/GNG4/GNAO1/GABRE/ARRB2/ADCY2/PDE4C/GNG7/GABRP/PDE3A	0.0498223590561893
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	16/1220	122/9376	1.00790110185434	MAP2K2/PLCG2/BAD/DIO2/PLCD3/HRAS/THRA/BMP4/TBC1D4/RXRB/NOTCH1/ITGB3/NOTCH4/ATP2A1/PLCB2/PFKFB2	0.0339726772430318
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	24/1220	184/9376	1.0024233784747	BOC/PLCG2/EFNB2/WNT5B/WNT5A/SEMA3A/HRAS/RRAS/EPHB4/PRKCZ/RAC3/LIMK2/RHOD/MYL5/SSH1/PLXNA2/RGS3/UNC5B/MYL12A/SEMA3F/NTN1/CAMK2G/ABLIM3/ABLIM2	0.0128396177552425
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	13/1220	99/9376	1.00917370425567	PLCG2/PLA2G4C/NTRK1/ITPR3/BDKRB2/IL1RAP/PRKCE/CAMK2G/ADCY2/MAP2K3/PLCB2/PTGER2/PLA2G4B	0.0354883247853894
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	5/1220	37/9376	1.03854674346478	NANS/PGM2/GALK1/PMM1/GALE	0.0908584477329408
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	20/1220	154/9376	0.998083883329785	MAP2K2/JUN/GUCY1A1/MYL6B/PLA2G4C/HRAS/CACNB2/ITPR3/MYLK/GNAO1/PRKAG2/GUCY1B1/OXT/CAMK1D/CAMK2G/ADCY2/CACNA2D3/PLCB2/PRKAA2/PLA2G4B	-0.00927249687673552
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	12/1220	93/9376	0.991644632469593	ACTN1/SORBS1/ACP1/FGFR1/RAC3/MYL5/SNAI1/RAP1B/MYL12A/VCL/AFDN/RASIP1	-0.031317695858154
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	3/1220	22/9376	1.04798807749627	HNMT/ALDH1B1/ALDH3A2	0.0871511162737467
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	4/1220	30/9376	1.02469945355191	ABCC3/SLC19A1/ABCC1/SLC46A1	0.0524037093331172
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/1220	14/9376	1.09789227166276	B4GALT2/B3GNT2	0.141760439561706
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	5/1220	38/9376	1.01121656600518	GNPDA1/PGM2/GALK1/PMM1/GALE	0.0267948743502506
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	8/1220	62/9376	0.991644632469593	RPS6KB2/IRS1/HSPA8/HRAS/SOD1/PRKAG2/ADCY2/PRKAA2	-0.0255282021970564
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	10/1220	78/9376	0.985287936107608	C2/JUN/IRF3/TLR4/IRAK1/PYCARD/IRF8/NOD1/C3/TICAM1	-0.0504606775617999
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	11/1220	86/9376	0.982996568814335	VAMP2/ATF4/CREB3/ITPR3/KCNMB3/KCNMA1/CAMK2G/ADCY2/RAB3A/PLCB2/RIMS2	-0.0612639340839498
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	11/1220	86/9376	0.982996568814335	SSPN/CACNB2/ITGA6/ITGB3/DTNA/ATP2A1/DES/LAMA1/ITGA2/CACNA2D3/ACTN2	-0.0612639340839498
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	29/1220	227/9376	0.98181555571604	BAX/MAP2K2/RPS6KB2/CYCS/RIPK1/EIF4EBP1/FAS/ATF4/TAPBPL/IRF3/GNG4/HRAS/CGAS/TRADD/CREB3/ITPR3/BAK1/BID/RAC3/GNAO1/ITGB3/PTGER3/VEGFA/CDKN2A/ADCY2/TRAF2/GNG7/PLCB2/PTGER2	-0.107263778967184
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	25/1220	196/9376	0.980260956841753	BAX/MAP2K2/PLCG2/RPS27A/CYCS/JUN/CLEC2B/FAS/IRF3/GNG4/HRAS/TRADD/IFNAR2/ITPR3/BAK1/BID/UBA52/C3/VEGFA/TICAM1/TRAF2/GNG7/MAP1LC3B2/IKBKE/MICB	-0.108008948140805
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	4/1220	31/9376	0.991644632469593	CSAD/ACADS/ALDH1B1/ALDH3A2	-0.0180211996116851
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	26/1220	205/9376	0.974714114354258	BAX/ACTN1/BAD/LTBR/ATP6V0D1/JUN/MRPS18B/SNW1/ATF4/IRF3/HRAS/TRADD/CREB3/BAK1/GSN/VAC14/PMAIP1/MAD1L1/HDAC10/NFKB2/C3/CDKN2A/CDK2/TRAF2/HDAC4/CDKN2B	-0.141570803945029
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	20/1220	158/9376	0.972815936916373	GADD45A/CDC25B/ANAPC13/MAD2L2/CHEK2/FBXO5/TGFB2/ANAPC15/ANAPC11/CDC7/MAD1L1/ANAPC2/MAD2L1BP/TGFB3/PPP2R5B/DBF4B/CDKN2A/CDK2/CDKN2B/PTTG1	-0.133275863777155
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	3/1220	23/9376	1.0024233784747	CTSA/KLK1/THOP1	0.00450025001303356
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	13/1220	103/9376	0.969982492439917	GNA14/JUN/FAS/TLR4/TGFB2/IRAK1/GNAO1/BDKRB2/GNAL/TGFB3/C3/TICAM1/PLCB2	-0.118470454921215
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/1220	15/9376	1.02469945355191	ST6GALNAC4/ST3GAL5	0.0370253179769532
NA	NA	hsa03272	Virion - Hepatitis viruses	6/1220	48/9376	0.960655737704918	LDLR/CD63/CD81/SCARB1/CLDN10/CLDN4	-0.105690195604475
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	4/1220	32/9376	0.960655737704918	IGBP1/ATG101/MLST8/GABARAPL2	-0.0862217684028696
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	11/1220	89/9376	0.949861853011604	NSF/GNG4/SLC38A5/GABARAPL2/HAP1/GNAO1/GABRE/ADCY2/SLC6A12/GNG7/GABRP	-0.183802961553984
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/1220	16/9376	0.960655737704918	A4GALT/B3GALNT1	-0.0609158654362865
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	11/1220	90/9376	0.939307832422587	BAX/RPS6KB2/EIF4EBP1/IRS1/ATF4/ATG101/HRAS/CREB3/PRKAG2/ADCY2/PRKAA2	-0.223751784844595
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	28/1220	226/9376	0.95215435949514	GRIA4/MAP2K2/PDE4D/BAD/JUN/FXYD1/GLI1/RRAS/CREB3/ORAI1/VIPR2/POMC/RAC3/EDN3/RAP1B/OXT/PTGER3/CAMK2G/ATP2A1/PLD1/AFDN/ADCY2/TSHR/PLD2/PDE4C/PTGER2/ADRB1/PDE3A	-0.281587252503003
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	17/1220	139/9376	0.93992216063215	MAP2K2/HSP90AB1/JUN/CTSD/ATF4/FKBP4/HSPA8/KRT10/HRAS/CREB3/ITPR3/POMC/GNAO1/SHC3/BCL2/ADCY2/PLCB2	-0.275983538529207
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	6/1220	50/9376	0.922229508196721	SRM/SAT2/PYCR1/GAMT/ALDH1B1/ALDH3A2	-0.213245112920063
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	12/1220	99/9376	0.931544957774466	BAX/MAP2K2/RPS6KB2/BAD/JUN/HRAS/NOTCH1/SHC3/BCL2/NOTCH4/CDKN2A/ADCY2	-0.264817210582673
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	9/1220	75/9376	0.922229508196721	GPX7/ATF4/HSPA5/CREB3/ITPR3/ADCY2/TSHR/GPX3/PLCB2	-0.261521621212225
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	8/1220	67/9376	0.91764130168828	MAP2K2/ATF4/HRAS/ITPR3/RAP1B/CAMK2G/PLCB2/RPS6KA2	-0.261650943493121
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/1220	17/9376	0.904146576663452	NRP2/MYH11	-0.152983400462957
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	9/1220	76/9376	0.910094909404659	PLTP/SORBS1/NR1H3/ANGPTL4/SLC27A5/RXRB/ACOX2/LPL/SLC27A6	-0.304352273207768
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	5/1220	43/9376	0.893633244376668	AGPAT2/SCARB1/PLPP1/PLPP2/PLA2G2A	-0.270368724713172
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	3/1220	26/9376	0.886759142496847	PLA2G4C/PLA2G2A/PLA2G4B	-0.223620164638358
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	17/1220	142/9376	0.920064650196259	RPS27A/ANAPC13/UBE2Q1/UBE2M/STUB1/UBE2S/MGRN1/UBE2G2/SOCS3/UBA52/ANAPC15/ANAPC11/UBE2D4/ANAPC2/ELOB/DDB2/NHLRC1	-0.371206063713079
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	8/1220	69/9376	0.89104300308862	MAP2K2/PLCG2/PLA2G4C/HRAS/RAC3/ALOX5/MAP2K3/PLA2G4B	-0.351319097188866
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	5/1220	44/9376	0.873323397913562	VAMP2/RAB11B/AQP3/NSF/CREB3	-0.325733423434297
Organismal Systems	Digestive system	hsa04978	Mineral absorption	7/1220	61/9376	0.881913464122548	SLC39A4/STEAP2/FTH1/SLC46A1/STEAP1/SLC26A3/SLC26A6	-0.357849830166582
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	10/1220	86/9376	0.893633244376668	MAP2K2/PLCG2/RPS6KB2/BAD/JUN/EIF4EBP1/HRAS/SHC3/CAMK2G/NRG2	-0.383242995726951
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/1220	18/9376	0.853916211293261	ACSF3/MCAT	-0.239924004196274
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	9/1220	78/9376	0.886759142496847	NFKBIB/JUN/CYBA/TLR4/TGFB2/IRAK1/TGFB3/C3/HLA-DMB	-0.388403043861397
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	12/1220	103/9376	0.895368454559924	EIF4A3/PABPN1/SSU72/DAZAP1/PELO/PNN/GSPT2/RNGTT/BCL2L2-PABPN1/SMG6/CLP1/PPP2R5B	-0.412950567684024
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	12/1220	103/9376	0.895368454559924	COL16A1/COL21A1/SLC3A2/COL8A1/SLC15A1/COL27A1/SLC1A1/SLC36A1/COL6A6/COL4A4/COL19A1/COL24A1	-0.412950567684024
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	8/1220	70/9376	0.878313817330211	CYCS/SSPN/CD55/BID/RAC3/DTNA/HLA-DMB/LAMA1	-0.395217082865633
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	8/1220	71/9376	0.865943200184715	PLCG2/ATP6V0D1/ATP6V0C/JUN/ATP6V1F/ATP6V1E2/NOD1/ATP6V1G2	-0.438517347387373
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	3/1220	28/9376	0.823419203747073	MOCS2/CBR1/TH	-0.361901247070368
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	4/1220	37/9376	0.830837394771821	FAHD1/FAH/ADH1C/TH	-0.398732820050998
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/1220	19/9376	0.808973252804141	GUSB/GALNS	-0.322351437536356
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	12/1220	105/9376	0.878313817330211	PLCG2/JUN/HRAS/RRAS/MRAS/RELB/ITPR3/PYCARD/CARD9/NFKB2/IL17D/IKBKE	-0.484952911855816
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	8/1220	72/9376	0.853916211293261	NFKBIB/RIPK1/IRF3/PIN1/CASP10/TRADD/TRAF2/IKBKE	-0.481238501913912
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	4/1220	38/9376	0.808973252804141	CD4/RFXANK/ORAI1/RFX5	-0.456337321626572
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	21/1220	181/9376	0.891658364278598	BAX/BAD/CYCS/ATP6V0D1/ATP6V0C/HSPD1/CTSD/RFXANK/TLR4/TGFB2/CASP10/TRADD/IRAK1/BID/CARD9/BCL2/TGFB3/C3/CAMK2G/HLA-DMB/RFX5	-0.569227343594494
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	13/1220	115/9376	0.868766928011404	ATF4/GNG4/HRAS/CREB3/ITPR3/CHRNA3/KCNQ3/GNAO1/BCL2/CAMK2G/ADCY2/GNG7/PLCB2	-0.547633766301624
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	5/1220	47/9376	0.817579351238228	SOCS2/IRS1/SOCS3/PRKCZ/PRKCE	-0.484877825478568
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	10/1220	90/9376	0.853916211293261	MAP2K2/NFKBIB/RPS6KB2/JUN/CD4/TLR4/HRAS/TICAM1/MAP2K3/NFKBIE	-0.538562219223784
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/1220	10/9376	0.768524590163934	TST	-0.283240094078582
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	18/1220	157/9376	0.881110995092409	WNT2/RASSF1/WNT5B/WNT5A/TGFB2/FRMD6/BMP4/DLG4/ID2/PRKCZ/TEAD4/GLI2/TGFB3/WNT2B/FZD10/WNT9B/FZD4/AJUBA	-0.581000566380125
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/1220	20/9376	0.768524590163934	NANS/NPL	-0.400775992183436
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	9/1220	82/9376	0.843502598960416	HSP90AB1/CD4/RFXANK/TAPBPL/HSPA8/HSPA5/HSPA2/HLA-DMB/RFX5	-0.550477619409093
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	3/1220	30/9376	0.768524590163934	PDHA1/MDH2/SUCLA2	-0.491110868882929
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	3/1220	30/9376	0.768524590163934	PLA2G4C/PLA2G2A/PLA2G4B	-0.491110868882929
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	5/1220	49/9376	0.784208765473403	JUN/ATF4/CREB3/TH/DLG4	-0.585716955397036
Genetic Information Processing	Transcription	hsa03040	Spliceosome	28/1220	243/9376	0.885542737637455	SNRPD1/HNRNPA1/EIF4A3/PHF5A/DDX46/PUF60/PQBP1/SF3A2/THOC3/PRPF38B/SNRNP40/PPIL1/CDC5L/DHX16/SNW1/SNRPD3/BUD31/U2AF1/HSPA8/LSM4/LSM3/SNRPB/SRSF3/SYF2/YJU2/GPKOW/XAB2/HNRNPA1L2	-0.699144116058951
Organismal Systems	Digestive system	hsa04970	Salivary secretion	10/1220	93/9376	0.826370527057994	VAMP2/BST1/GUCY1A1/ITPR3/KCNMA1/GUCY1B1/ADCY2/ADRA1D/PLCB2/ADRB1	-0.650800219837167
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	3/1220	31/9376	0.743733474352195	TKT/PGM2/ALDOA	-0.552726160241934
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	8/1220	76/9376	0.808973252804141	ITPR3/MYLK/GAST/SLC26A7/CAMK2G/HRH2/ADCY2/PLCB2	-0.646675559387714
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	6/1220	59/9376	0.781550430675188	MGLL/IRS1/PTGER3/ADCY2/TSHR/ADRB1	-0.650977676515826
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	7/1220	68/9376	0.791128254580521	DHRS4L2/DHRS3/ADH1C/RDH13/UGT2B7/RDH10/LRAT	-0.668548486452362
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	7/1220	68/9376	0.791128254580521	MAP2K2/RPS6KB2/BAD/PIM1/EIF4EBP1/HRAS/PER2	-0.668548486452362
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	17/1220	155/9376	0.842897937599154	ATP6V0D1/ATP6V0C/CYBA/TLR4/ATP6V1F/TUBA1A/SCARB1/ATP6V1E2/TUBB2A/THBS1/ATP6V1G2/ITGB3/COLEC11/TUBA1B/C3/HLA-DMB/ITGA2	-0.762756064766697
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	13/1220	122/9376	0.818919645256651	MAP2K2/PLCG2/SOCS2/IRS1/ATF4/HRAS/CREB3/ITPR3/SOCS3/SHC3/ADCY2/MAP2K3/PLCB2	-0.778598296814792
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/1220	23/9376	0.668282252316465	RXYLT1/B4GALT2	-0.616004810607601
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	2/1220	23/9376	0.668282252316465	FDPS/PMVK	-0.616004810607601
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	7/1220	71/9376	0.757700300161625	MAP2K2/SOCS2/HRAS/SOCS3/TH/SHC3/PRL	-0.792594048136943
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	6/1220	62/9376	0.743733474352195	PSENEN/SNW1/TLE2/NOTCH1/NOTCH4/PSEN2	-0.782972581309712
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	15/1220	142/9376	0.81182175017317	PLCG2/FHL2/JUN/CYBA/TGFB2/IFNAR2/RELB/ITPR3/SOCS3/NFKB2/ITGB3/SQSTM1/ATP2A1/TRAF2/JUND	-0.873867538781513
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	11/1220	108/9376	0.782756527018822	EIF4A3/THOC3/NUP42/PHAX/SNUPN/RAN/PNN/TPR/RANGAP1/IPO4/NUP210L	-0.878198209328541
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	9/1220	91/9376	0.760079264997298	MAP2K2/NFKBIB/PLCG2/JUN/HRAS/CD81/RAC3/CARD11/NFKBIE	-0.889456002560768
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	10/1220	100/9376	0.768524590163934	CD59/CD4/CD55/ITGA6/KITLG/ITGB3/HLA-DMB/ITGA2/CD1D/THPO	-0.900018500402701
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	15/1220	144/9376	0.800546448087432	WNT2/MAP2K2/WNT5B/WNT5A/FGFR1/TBX3/HRAS/BMP4/ID2/ID4/WNT2B/FZD10/WNT9B/FZD4/LEFTY2	-0.932829061820643
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	5/1220	55/9376	0.698658718330849	ASAH1/DEGS1/SMPD2/PLPP1/PLPP2	-0.866833459954505
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	11/1220	110/9376	0.768524590163934	HSP90AB1/CDC25B/ANAPC13/MAD2L2/ANAPC15/ANAPC11/MAD1L1/ANAPC2/CDK2/ADCY2/RPS6KA2	-0.944456590149336
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	12/1220	119/9376	0.774982779997245	RIPK1/JUN/FAS/ATF4/CASP10/TRADD/CREB3/SOCS3/MAP3K5/RPS6KA4/TRAF2/MAP2K3	-0.955390786284871
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	16/1220	154/9376	0.798467106663828	TPM1/TPM4/ATF4/TPM2/CACNB2/CREB3/SCN5A/BCL2/PPP2R5B/CAMK2G/ATP2A1/ADCY2/ADRA1D/CACNA2D3/PLCB2/ADRB1	-0.975260615946406
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	6/1220	65/9376	0.709407313997478	MAP2K2/HRAS/ITPR3/CACNA1H/ARRB2/PLCB2	-0.909222426305944
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	14/1220	138/9376	0.779662627702542	ANAPC13/MAD2L2/FBXO5/ITPR3/ANAPC15/ANAPC11/MAD1L1/ANAPC2/PPP2R5B/CAMK2G/CDK2/ADCY2/RPS6KA2/PTTG1	-1.00847625040092
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/1220	15/9376	0.512349726775956	ACP1	-0.731004286783914
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/1220	37/9376	0.623128046078866	FAS/THOP1/PLCB2	-0.888324087834936
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/1220	27/9376	0.569277474195507	ACADS/ACSM3	-0.866809838733472
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	12/1220	122/9376	0.755925826390755	RPS6KB2/RAB11B/EIF4EBP1/IRS1/CREB3/G6PC3/PFKFB3/TBC1D1/PRKAG2/PPP2R5B/PRKAA2/PFKFB2	-1.0494552881674
NA	NA	hsa04081	Hormone signaling	23/1220	219/9376	0.807126281907328	IGF2/PTH1R/GNA14/RAMP1/ADRA2C/DIO2/IRS1/GNG4/THRA/VIPR2/POMC/GNAO1/GAST/ITGB3/OXT/ADCY2/ADRA1D/TSHR/GNG7/PLCB2/ADRB1/THPO/PRL	-1.1169801310597
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	11/1220	115/9376	0.735110477548111	PLA2G4C/CYP4X1/GNG4/HRAS/ITPR3/GNAO1/ALOX5/GNG7/PLCB2/KCND2/PLA2G4B	-1.10538025694295
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	13/1220	133/9376	0.751189449032417	GRIA4/ATF4/GNG4/CREB3/ITPR3/TH/GNAO1/GNAL/PPP2R5B/CAMK2G/ARRB2/GNG7/PLCB2	-1.11767382926537
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	6/1220	69/9376	0.668282252316465	GRIA4/JUN/ATF4/CREB3/TH/CAMK2G	-1.06958509266266
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	18/1220	178/9376	0.777159697918585	SERPINF1/WNT2/JUN/SFRP1/WNT5B/WNT5A/LRP5/FRAT2/RAC3/TLE2/BAMBI/PORCN/WNT2B/CAMK2G/FZD10/WNT9B/PLCB2/FZD4	-1.16087105324673
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	11/1220	116/9376	0.728773318258903	ACTN1/PLCG2/THY1/CYBA/CLDN10/MYL5/RAP1B/MYL12A/VCL/CLDN4/AFDN	-1.13679683812469
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/1220	17/9376	0.452073288331726	SEPHS2	-0.874498673471348
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	11/1220	117/9376	0.722544486478913	MORF4L2/SMARCB1/SMARCD3/POLE3/INO80E/ZNHIT1/TFPT/DMAP1/YEATS4/INO80C/DPF1	-1.16796866989704
Organismal Systems	Digestive system	hsa04976	Bile secretion	8/1220	90/9376	0.683132969034608	EPHX1/LDLR/SCARB1/SLC27A5/ABCC3/UGT2B7/ADCY2/NCEH1	-1.16818308798216
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	10/1220	109/9376	0.705068431343059	MAP2K2/RIPK1/JUN/IRF3/TLR4/IFNAR2/IRAK1/TICAM1/MAP2K3/IKBKE	-1.19782086310596
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	3/1220	41/9376	0.56233506597361	GRIA4/GABRE/GABRP	-1.08618415790332
NA	NA	hsa04082	Neuroactive ligand signaling	20/1220	199/9376	0.772386522777824	GRIA4/ADRA2C/GNG4/P2RY1/POMC/CHRNA3/GNAO1/P2RY11/GRM7/GABRE/GNAL/SLC1A1/HRH2/ADCY2/ADRA1D/SLC6A12/GNG7/PLCB2/GABRP/ADRB1	-1.25516578117574
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	18/1220	183/9376	0.755925826390755	NOP56/EIF6/NHP2/IMP3/POP5/AK6/RPP25L/RRP7A/UTP14A/POP7/GNL2/RIOK1/MPHOSPH10/RAN/UTP6/UTP15/TBL3/RPP25	-1.28957227450624
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/1220	42/9376	0.548946135831382	CYP1B1/ALDH1B1/ALDH3A2	-1.13304223722819
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	20/1220	201/9376	0.764701084740233	BAX/HOXA11/NGFR/GADD45A/NFKBIZ/NUPR1/NTRK1/BCL6/BAK1/ASPSCR1/ID2/SUPT3H/RXRB/ELANE/DOT1L/BCL2L1/DDB2/RUNX2/PER2/WT1	-1.30419299220894
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	5/1220	63/9376	0.609940150923757	KMT5A/ALDH1B1/HYKK/ALDH3A2/DOT1L	-1.20138904265069
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	9/1220	102/9376	0.678109932497589	BST1/ITPR3/KCNMA1/RAP1B/ATP2A1/ADCY2/SLC26A3/PLCB2/PLA2G2A	-1.26415713744962
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	7/1220	83/9376	0.648153268812957	L3MBTL2/SFMBT2/CBX3/UBE2D4/ASXL3/EPOP/CBX8	-1.24520697064657
Cellular Processes	Cell motility	hsa04814	Motor proteins	19/1220	194/9376	0.752678722325503	ACTA2/TPM1/TPM4/MYO1E/DYNLRB1/KIF9/MYL6B/TPM2/CAPZB/DYNLT3/TUBA1A/TUBB2A/MYL5/KIF1C/MYL12A/TUBA1B/DNAH1/MYH11/MYO18A	-1.34623428645659
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	19/1220	195/9376	0.748818831441782	MAP2K2/PLCG2/SLC25A6/CYBA/SLC25A5/VDAC1/TLR4/VDAC2/GSDMD/HDAC10/ELANE/ITGB3/C3/AGER/C5AR1/HDAC4/CLCN4/SLC25A4/PLCB2	-1.37083862763018
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	3/1220	44/9376	0.523994038748137	HSPD1/FAS/HLA-DMB	-1.2239912405284
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	15/1220	160/9376	0.720491803278689	CDH3/VSIR/CD4/CNTN1/ITGA6/NCAM2/SDC4/CLDN10/ICAM3/PVR/NLGN4X/ICAM2/CLDN4/HLA-DMB/MADCAM1	-1.37914602360069
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/1220	20/9376	0.384262295081967	CYP51A1	-1.06608684606302
Organismal Systems	Sensory system	hsa04742	Taste transduction	7/1220	86/9376	0.625543271063668	P2RY1/ITPR3/ENTPD2/TAS2R1/PLCB2/SCN2A/TAS2R4	-1.34918018065595
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	5/1220	66/9376	0.582215598609041	JUN/TLR4/TGFB2/TGFB3/HLA-DMB	-1.31727452549926
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	8/1220	99/9376	0.621029971849644	C2/CFI/KRT10/DEFB1/C3/HLA-DMB/CFD/C5AR1	-1.46603935205492
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	38/1220	370/9376	0.78929552503323	GRIA4/PTH1R/ADRA2C/GAL/LPAR1/TMEM97/EDNRB/QRFPR/P2RY1/THRA/F2RL2/VIPR2/NMB/POMC/CHRNA3/P2RY11/BDKRB2/EDN3/GRM7/OXT/GALR1/GABRE/ADM/C3/PTGER3/HRH2/C5AR1/NPW/ADRA1D/TSHR/PTGER2/GABRP/ADRB1/CHRNA5/NPB/PRL/GRID1/CHRNE	-1.59932083498812
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	3/1220	48/9376	0.480327868852459	G6PC3/MGAM/PLCB2	-1.39599133360911
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/1220	23/9376	0.334141126158232	CA4	-1.23650987122824
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/1220	37/9376	0.415418697385911	RIMKLB/ADSL	-1.37791535561888
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	3/1220	50/9376	0.461114754098361	LTBR/HLA-DMB/MADCAM1	-1.47761242662485
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/1220	38/9376	0.404486626402071	IRS1/HSD11B2	-1.42260171358022
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	7/1220	94/9376	0.57230554586676	HSP90AB1/JUN/TRADD/TRAF2/IL17D/JUND/IKBKE	-1.61177237754221
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/1220	39/9376	0.394115174443043	FAS/HLA-DMB	-1.4663770156838
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/1220	26/9376	0.295586380832283	NKX6-1	-1.39102699295085
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	17/1220	193/9376	0.676938758175486	NFKBIB/PLCG2/BAD/GRK5/GRK4/CXCL14/GNG4/HRAS/PRKCZ/RAC3/SHC3/RAP1B/ARRB2/RASGRP2/ADCY2/GNG7/PLCB2	-1.75387309316958
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	13/1220	157/9376	0.636357940900073	MAP2K2/GAS6/ATP8A2/UQCRFS1/NR1H3/MFGE8/THBS1/ITGB3/ALOX5/AGER/CAMK2G/ATP2A1/PTGER2	-1.77708815429073
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	3/1220	54/9376	0.42695810564663	FAS/HLA-DMB/TSHR	-1.63326121659113
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	8/1220	109/9376	0.564054745074447	NFKBIB/HSP90AB1/JUN/CD4/RXRB/IL1RAP/HLA-DMB/NFKBIE	-1.77052705446146
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/1220	29/9376	0.265008479366874	GUCA1B	-1.53310588729014
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	10/1220	133/9376	0.577838037717244	MAP2K2/PLCG2/FAS/HRAS/IFNAR2/BID/RAC3/SHC3/ICAM2/MICB	-1.89638009770827
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	2/1220	45/9376	0.341566484517304	FAS/HLA-DMB	-1.71230465098189
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	6/1220	93/9376	0.495822316234796	NFKBIB/JUN/CD4/NOTCH1/HLA-DMB/NFKBIE	-1.88976526779519
Human Diseases	Immune disease	hsa05310	Asthma	1/1220	32/9376	0.24016393442623	HLA-DMB	-1.66515790228042
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/1220	33/9376	0.232886239443616	PDHA1	-1.7072633356352
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	8/1220	122/9376	0.50395055092717	MAP2K2/NFKBIB/JUN/CD4/HRAS/PPP2R5B/CARD11/NFKBIE	-2.13288325357783
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	9/1220	143/9376	0.48368680499828	SNRPD1/ACTN1/C2/SNRPD3/SNRPB/ELANE/C6/C3/HLA-DMB	-2.40622796619593
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/1220	44/9376	0.174664679582712	TAF7L	-2.12224905762251
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	25/1220	323/9376	0.594833274120692	MAP2K2/CYP1B1/TPM1/PLCG2/RASSF1/CDC25B/PIM1/IRS1/TGFB2/HRAS/VIM/BAK1/PDCD4/THBS1/NOTCH1/ITGB3/BCL2/ABCC1/BCL2L11/NOTCH4/PRKCE/VEGFA/CDKN2A/TIMP3/HDAC4	-2.86593091920775
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	9/1220	168/9376	0.411709601873536	PIM1/SOCS2/HRAS/IFNAR2/SOCS3/BCL2/BCL2L1/THPO/PRL	-2.97571059013061
Human Diseases	Substance dependence	hsa05034	Alcoholism	11/1220	191/9376	0.442605784911166	ATF4/GNG4/HRAS/CREB3/TH/GNAO1/HDAC10/SLC29A3/SHC3/HDAC4/GNG7	-3.01000006773009
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	3/1220	100/9376	0.23055737704918	LTBR/CXCL14/TNFRSF10D	-2.99173288490802
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	19/1220	298/9376	0.489998899768952	NGFR/LTBR/ACVRL1/CD4/FAS/CXCL14/TGFB2/TNFRSF10D/BMP4/IFNAR2/TNFRSF12A/IL32/IL1RAP/TGFB3/IL1RL1/EDA2R/THPO/IL17D/PRL	-3.46027887049242
NA	NA	hsa04382	Cornified envelope formation	9/1220	217/9376	0.318742917579512	KAZN/S100A13/KRT10/ITGA6/CLDN10/COL4A4/PPP2R5B/CLDN4/CDSN	-3.92684548369327
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	4/1220	449/9376	0.0684654423308628	GNAL/CAMK2G/ARRB2/GNG7	-7.8234141084213