ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003735 structural constituent of ribosome 79/2632 175/18639 0.451428571428571 3.19687581415545 2.54689868781813e-23 3.2727648138463e-20 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 30/2632 68/18639 0.441176470588235 3.12427364562846 1.96420681231866e-09 1.13305660468074e-06 GO:0019843 rRNA binding 29/2632 65/18639 0.446153846153846 3.15952186111761 2.64526833777604e-09 1.13305660468074e-06 GO:0015078 proton transmembrane transporter activity 55/2632 185/18639 0.297297297297297 2.1053663846217 2.97314840705999e-08 9.5512392576802e-06 GO:0009055 electron transfer activity 39/2632 116/18639 0.336206896551724 2.38091198511686 8.44349194548337e-08 2.16997742998923e-05 GO:0003954 NADH dehydrogenase activity 20/2632 44/18639 0.454545454545455 3.2189486045869 5.33837600682423e-07 0.000100436281365373 GO:0015399 primary active transmembrane transporter activity 48/2632 166/18639 0.289156626506024 2.04771670267697 5.47123711717988e-07 0.000100436281365373 GO:0008137 NADH dehydrogenase (ubiquinone) activity 19/2632 41/18639 0.463414634146341 3.28175735784714 7.08519818762149e-07 0.00011380599588867 GO:0022853 active monoatomic ion transmembrane transporter activity 36/2632 118/18639 0.305084745762712 2.16051465663799 3.5745139938668e-06 0.000510361164679871 GO:0043295 glutathione binding 8/2632 10/18639 0.8 5.66534954407295 5.39610997877929e-06 0.000693400132273139 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 22/2632 58/18639 0.379310344827586 2.6861571114139 5.95784911634564e-06 0.000695985101318559 GO:1900750 oligopeptide binding 8/2632 11/18639 0.727272727272727 5.15031776733904 1.73174555942984e-05 0.00171176387989795 GO:1990948 ubiquitin ligase inhibitor activity 8/2632 11/18639 0.727272727272727 5.15031776733904 1.73174555942984e-05 0.00171176387989795 GO:0055105 ubiquitin-protein transferase inhibitor activity 9/2632 15/18639 0.6 4.24901215805471 4.91339465614152e-05 0.00435104708648749 GO:0016651 oxidoreductase activity, acting on NAD(P)H 27/2632 88/18639 0.306818181818182 2.17279030809616 5.07904329161963e-05 0.00435104708648749 GO:0072341 modified amino acid binding 27/2632 91/18639 0.296703296703297 2.1011598583787 9.65112563775867e-05 0.00775106027782493 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 20/2632 61/18639 0.327868852459016 2.32186456724301 0.000170540835970936 0.0128908808366267 GO:0055106 ubiquitin-protein transferase regulator activity 14/2632 36/18639 0.388888888888889 2.75398936170213 0.000214556067434059 0.015316919258487 GO:0043022 ribosome binding 30/2632 112/18639 0.267857142857143 1.896880427703 0.000308009857415299 0.0208311929883505 GO:0043021 ribonucleoprotein complex binding 42/2632 177/18639 0.23728813559322 1.68040028849621 0.000407867651752794 0.026205496625117 GO:0031625 ubiquitin protein ligase binding 64/2632 302/18639 0.211920529801325 1.50075484611204 0.000484341806538942 0.0296371057810734 GO:0016853 isomerase activity 42/2632 180/18639 0.233333333333333 1.65239361702128 0.000590618472808678 0.0342537279543888 GO:0044389 ubiquitin-like protein ligase binding 67/2632 322/18639 0.208074534161491 1.47351870905624 0.000613101745487114 0.0342537279543888 GO:0016675 oxidoreductase activity, acting on a heme group of donors 8/2632 16/18639 0.5 3.54084346504559 0.000696609201954612 0.0372976176879865 GO:0051540 metal cluster binding 22/2632 77/18639 0.285714285714286 2.0233391228832 0.000731768716815588 0.0376129120443212 GO:0071813 lipoprotein particle binding 12/2632 32/18639 0.375 2.65563259878419 0.000883808548817687 0.0420627401937307 GO:0071814 protein-lipid complex binding 12/2632 32/18639 0.375 2.65563259878419 0.000883808548817687 0.0420627401937307 GO:0070513 death domain binding 6/2632 10/18639 0.6 4.24901215805471 0.000992312412636396 0.045540051794206 GO:0045296 cadherin binding 68/2632 334/18639 0.203592814371257 1.44178057259341 0.00103219575771097 0.0457369499537448 GO:0030169 low-density lipoprotein particle binding 8/2632 17/18639 0.470588235294118 3.33255855533703 0.00115357804228769 0.0494115928113227 GO:0051536 iron-sulfur cluster binding 21/2632 76/18639 0.276315789473684 1.95678191489362 0.00152594719960081 0.0632529726286143 GO:0008175 tRNA methyltransferase activity 12/2632 34/18639 0.352941176470588 2.49941891650277 0.00163538393008835 0.0656708859426104 GO:0005112 Notch binding 10/2632 26/18639 0.384615384615385 2.72372574234276 0.00188818815821568 0.0735249025244591 GO:0016860 intramolecular oxidoreductase activity 16/2632 53/18639 0.30188679245283 2.13786775248036 0.00199386270828804 0.0753562817691216 GO:0008135 translation factor activity, RNA binding 22/2632 83/18639 0.265060240963855 1.87707364412056 0.00213986612789409 0.0785636564098258 GO:0180051 translation factor activity 22/2632 84/18639 0.261904761904762 1.8547275293096 0.00251972804158642 0.0860964843875719 GO:0004129 cytochrome-c oxidase activity 7/2632 15/18639 0.466666666666667 3.30478723404255 0.00252020864056666 0.0860964843875719 GO:0051082 unfolded protein binding 29/2632 121/18639 0.239669421487603 1.69726380969128 0.00254604389628617 0.0860964843875719 GO:0017134 fibroblast growth factor binding 9/2632 23/18639 0.391304347826087 2.77109488568786 0.00276093642524121 0.0886950826608737 GO:0099186 structural constituent of postsynapse 9/2632 23/18639 0.391304347826087 2.77109488568786 0.00276093642524121 0.0886950826608737 GO:0030515 snoRNA binding 11/2632 32/18639 0.34375 2.43432988221885 0.00321500164121318 0.100762856316072 GO:0051087 protein-folding chaperone binding 31/2632 134/18639 0.23134328358209 1.63830070770766 0.00331349473304022 0.101377160284683 GO:0022804 active transmembrane transporter activity 85/2632 457/18639 0.185995623632385 1.31716277693162 0.004274093966677 0.127725831329766 GO:0033218 amide binding 50/2632 247/18639 0.202429149797571 1.43353986439093 0.00497063526869717 0.145165143642633 GO:0003779 actin binding 82/2632 443/18639 0.18510158013544 1.31083144078437 0.00561335918440146 0.160292590043464 GO:0051787 misfolded protein binding 7/2632 17/18639 0.411764705882353 2.9159887359199 0.00588805376152678 0.164481501816563 GO:0098918 structural constituent of synapse 10/2632 30/18639 0.333333333333333 2.36056231003039 0.00626617989997756 0.171320024924918 GO:0051015 actin filament binding 43/2632 209/18639 0.205741626794258 1.4569977894446 0.00650565415341453 0.174161783065368 GO:0047429 nucleoside triphosphate diphosphatase activity 5/2632 10/18639 0.5 3.54084346504559 0.00758830200984635 0.195019361653051 GO:0097177 mitochondrial ribosome binding 5/2632 10/18639 0.5 3.54084346504559 0.00758830200984635 0.195019361653051 GO:0031072 heat shock protein binding 29/2632 131/18639 0.221374045801527 1.56770168681408 0.0083806931033 0.209460039394396 GO:0003746 translation elongation factor activity 7/2632 18/18639 0.388888888888889 2.75398936170213 0.00847620392880044 0.209460039394396 GO:0004364 glutathione transferase activity 9/2632 27/18639 0.333333333333333 2.36056231003039 0.009348823984133 0.226664883388885 GO:0005525 GTP binding 70/2632 378/18639 0.185185185185185 1.31142350557244 0.00978954499964695 0.232954913417525 GO:0004602 glutathione peroxidase activity 8/2632 23/18639 0.347826086956522 2.46319545394476 0.0106334548787021 0.245128260570263 GO:0140101 catalytic activity, acting on a tRNA 30/2632 139/18639 0.215827338129496 1.52842163958803 0.0106826323672644 0.245128260570263 GO:0016504 peptidase activator activity 15/2632 57/18639 0.263157894736842 1.86360182370821 0.0109559783901076 0.246990039145407 GO:0051537 2 iron, 2 sulfur cluster binding 9/2632 28/18639 0.321428571428571 2.2762565132436 0.0120854818103894 0.267755933212937 GO:0034511 U3 snoRNA binding 5/2632 11/18639 0.454545454545455 3.2189486045869 0.0123098394664352 0.268104130752022 GO:0004089 carbonate dehydratase activity 6/2632 15/18639 0.4 2.83267477203647 0.0125794035129106 0.269408891901501 GO:0048027 mRNA 5'-UTR binding 8/2632 24/18639 0.333333333333333 2.36056231003039 0.0140148825513424 0.286180555366711 GO:0070300 phosphatidic acid binding 8/2632 24/18639 0.333333333333333 2.36056231003039 0.0140148825513424 0.286180555366711 GO:0019838 growth factor binding 29/2632 136/18639 0.213235294117647 1.51006559538709 0.0140306420140878 0.286180555366711 GO:0044183 protein folding chaperone 18/2632 75/18639 0.24 1.69960486322188 0.0150914113107919 0.298410099596716 GO:0031593 polyubiquitin modification-dependent protein binding 15/2632 59/18639 0.254237288135593 1.80042888053166 0.0150946742986666 0.298410099596716 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 34/2632 167/18639 0.203592814371257 1.44178057259341 0.016622696549332 0.316613713627097 GO:0019001 guanyl nucleotide binding 72/2632 400/18639 0.18 1.27470364741641 0.0168132344691244 0.316613713627097 GO:0032561 guanyl ribonucleotide binding 72/2632 400/18639 0.18 1.27470364741641 0.0168132344691244 0.316613713627097 GO:0016741 transferase activity, transferring one-carbon groups 42/2632 215/18639 0.195348837209302 1.38339930727363 0.0170010476577974 0.316613713627097 GO:0008081 phosphoric diester hydrolase activity 20/2632 87/18639 0.229885057471264 1.62797400691751 0.017256866990884 0.31678677261837 GO:0008142 oxysterol binding 6/2632 16/18639 0.375 2.65563259878419 0.0177639073649646 0.321501703718022 GO:0005201 extracellular matrix structural constituent 34/2632 168/18639 0.202380952380952 1.4331985453756 0.0180938025750903 0.322924115402653 GO:0008168 methyltransferase activity 40/2632 204/18639 0.196078431372549 1.38856606472376 0.0183792251830417 0.323524717263131 GO:0008106 alcohol dehydrogenase (NADP+) activity 9/2632 30/18639 0.3 2.12450607902736 0.0192813849869335 0.334818644705534 GO:0140662 ATP-dependent protein folding chaperone 11/2632 40/18639 0.275 1.94746390577508 0.0197994428115798 0.339230453505067 GO:0008157 protein phosphatase 1 binding 8/2632 26/18639 0.307692307692308 2.17898059387421 0.023008473286631 0.389024844385801 GO:0004033 aldo-keto reductase (NADPH) activity 10/2632 36/18639 0.277777777777778 1.96713525835866 0.0240108658154276 0.399365573294034 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 6/2632 17/18639 0.352941176470588 2.49941891650277 0.0242416456941126 0.399365573294034 GO:0004601 peroxidase activity 14/2632 57/18639 0.245614035087719 1.73936170212766 0.0247309945693657 0.402269974957404 GO:0016835 carbon-oxygen lyase activity 18/2632 79/18639 0.227848101265823 1.61354892078027 0.025109128490529 0.403315376379122 GO:0005542 folic acid binding 5/2632 13/18639 0.384615384615385 2.72372574234276 0.026894651448759 0.416381049538015 GO:0008035 high-density lipoprotein particle binding 5/2632 13/18639 0.384615384615385 2.72372574234276 0.026894651448759 0.416381049538015 GO:0009982 pseudouridine synthase activity 5/2632 13/18639 0.384615384615385 2.72372574234276 0.026894651448759 0.416381049538015 GO:0004857 enzyme inhibitor activity 73/2632 416/18639 0.175480769230769 1.24269986994389 0.0275754872261344 0.421839298637889 GO:0042910 xenobiotic transmembrane transporter activity 9/2632 32/18639 0.28125 1.99172444908815 0.0291511296806076 0.440042071744157 GO:0016209 antioxidant activity 19/2632 86/18639 0.22093023255814 1.56455874036898 0.0294502865136167 0.440042071744157 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 6/2632 18/18639 0.333333333333333 2.36056231003039 0.0321243665767686 0.456257164035336 GO:0031690 adrenergic receptor binding 6/2632 18/18639 0.333333333333333 2.36056231003039 0.0321243665767686 0.456257164035336 GO:0034185 apolipoprotein binding 6/2632 18/18639 0.333333333333333 2.36056231003039 0.0321243665767686 0.456257164035336 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 6/2632 18/18639 0.333333333333333 2.36056231003039 0.0321243665767686 0.456257164035336 GO:0001786 phosphatidylserine binding 14/2632 59/18639 0.23728813559322 1.68040028849621 0.0326658825612848 0.456257164035336 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 14/2632 59/18639 0.23728813559322 1.68040028849621 0.0326658825612848 0.456257164035336 GO:0005543 phospholipid binding 85/2632 497/18639 0.17102615694165 1.21115370031741 0.0331624468640516 0.457440218191298 GO:0003924 GTPase activity 59/2632 331/18639 0.178247734138973 1.26229464917033 0.0334625529260561 0.457440218191298 GO:0042578 phosphoric ester hydrolase activity 64/2632 363/18639 0.176308539944904 1.24856188299128 0.0340138891570298 0.458002424610236 GO:0042887 amide transmembrane transporter activity 10/2632 38/18639 0.263157894736842 1.86360182370821 0.0343713038496143 0.458002424610236 GO:1901681 sulfur compound binding 50/2632 275/18639 0.181818181818182 1.28757944183476 0.0345729456709672 0.458002424610236 GO:0016866 intramolecular transferase activity 8/2632 28/18639 0.285714285714286 2.0233391228832 0.0354296736764949 0.459716462281459 GO:0061134 peptidase regulator activity 42/2632 226/18639 0.185840707964602 1.31606571267181 0.0362365791111496 0.459716462281459 GO:0005347 ATP transmembrane transporter activity 5/2632 14/18639 0.357142857142857 2.52917390360399 0.0370829436069734 0.459716462281459 GO:0008191 metalloendopeptidase inhibitor activity 5/2632 14/18639 0.357142857142857 2.52917390360399 0.0370829436069734 0.459716462281459 GO:0008195 phosphatidate phosphatase activity 5/2632 14/18639 0.357142857142857 2.52917390360399 0.0370829436069734 0.459716462281459 GO:0008559 ABC-type xenobiotic transporter activity 5/2632 14/18639 0.357142857142857 2.52917390360399 0.0370829436069734 0.459716462281459 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 10/2632 39/18639 0.256410256410256 1.81581716156184 0.0405715000171626 0.459716462281459 GO:0004090 carbonyl reductase (NADPH) activity 4/2632 10/18639 0.4 2.83267477203647 0.0410576784477439 0.459716462281459 GO:0016427 tRNA (cytidine) methyltransferase activity 4/2632 10/18639 0.4 2.83267477203647 0.0410576784477439 0.459716462281459 GO:0016783 sulfurtransferase activity 4/2632 10/18639 0.4 2.83267477203647 0.0410576784477439 0.459716462281459 GO:0016889 DNA endonuclease activity, producing 3'-phosphomonoesters 4/2632 10/18639 0.4 2.83267477203647 0.0410576784477439 0.459716462281459 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 4/2632 10/18639 0.4 2.83267477203647 0.0410576784477439 0.459716462281459 GO:0043121 neurotrophin binding 4/2632 10/18639 0.4 2.83267477203647 0.0410576784477439 0.459716462281459 GO:0050308 sugar-phosphatase activity 4/2632 10/18639 0.4 2.83267477203647 0.0410576784477439 0.459716462281459 GO:0070097 delta-catenin binding 4/2632 10/18639 0.4 2.83267477203647 0.0410576784477439 0.459716462281459 GO:0003756 protein disulfide isomerase activity 6/2632 19/18639 0.315789473684211 2.23632218844985 0.0414996962059527 0.459716462281459 GO:0005346 purine ribonucleotide transmembrane transporter activity 6/2632 19/18639 0.315789473684211 2.23632218844985 0.0414996962059527 0.459716462281459 GO:0005520 insulin-like growth factor binding 6/2632 19/18639 0.315789473684211 2.23632218844985 0.0414996962059527 0.459716462281459 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 6/2632 19/18639 0.315789473684211 2.23632218844985 0.0414996962059527 0.459716462281459 GO:0016836 hydro-lyase activity 14/2632 61/18639 0.229508196721311 1.62530519707011 0.042298658410605 0.461484646820689 GO:0140098 catalytic activity, acting on RNA 67/2632 387/18639 0.17312661498708 1.22602848660493 0.0429683207348552 0.461484646820689 GO:0004622 lysophospholipase activity 7/2632 24/18639 0.291666666666667 2.0654920212766 0.0430958425046558 0.461484646820689 GO:0015295 solute:proton symporter activity 7/2632 24/18639 0.291666666666667 2.0654920212766 0.0430958425046558 0.461484646820689 GO:0008173 RNA methyltransferase activity 15/2632 67/18639 0.223880597014925 1.58545229778161 0.0443786208783438 0.471293618418775 GO:0051539 4 iron, 4 sulfur cluster binding 11/2632 45/18639 0.244444444444444 1.73107902735562 0.0449655671840199 0.473612736323488 GO:0003743 translation initiation factor activity 12/2632 51/18639 0.235294117647059 1.66627927766851 0.0485467347602555 0.507175237129498 GO:0016829 lyase activity 37/2632 200/18639 0.185 1.31011208206687 0.0496623897196515 0.514646538627033 GO:0004519 endonuclease activity 25/2632 127/18639 0.196850393700787 1.39403286025417 0.0511780805956521 0.522257123327442 GO:0001968 fibronectin binding 8/2632 30/18639 0.266666666666667 1.88844984802432 0.0517188437016073 0.522257123327442 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 6/2632 20/18639 0.3 2.12450607902736 0.0524289252211985 0.522257123327442 GO:0016505 peptidase activator activity involved in apoptotic process 6/2632 20/18639 0.3 2.12450607902736 0.0524289252211985 0.522257123327442 GO:0031418 L-ascorbic acid binding 6/2632 20/18639 0.3 2.12450607902736 0.0524289252211985 0.522257123327442 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 18/2632 86/18639 0.209302325581395 1.48221354350746 0.0536315375583305 0.530127121249652 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 12/2632 52/18639 0.230769230769231 1.63423544540566 0.05531590547875 0.54052920407995 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 24/2632 122/18639 0.19672131147541 1.39311874034581 0.0555251789405085 0.54052920407995 GO:0015217 ADP transmembrane transporter activity 4/2632 11/18639 0.363636363636364 2.57515888366952 0.0574850150084918 0.547172179895644 GO:0019203 carbohydrate phosphatase activity 4/2632 11/18639 0.363636363636364 2.57515888366952 0.0574850150084918 0.547172179895644 GO:0045294 alpha-catenin binding 4/2632 11/18639 0.363636363636364 2.57515888366952 0.0574850150084918 0.547172179895644 GO:0140359 ABC-type transporter activity 11/2632 47/18639 0.234042553191489 1.65741609002134 0.0593865845663999 0.561115890939882 GO:1902936 phosphatidylinositol bisphosphate binding 22/2632 111/18639 0.198198198198198 1.4035775897478 0.0603315012697192 0.565883059354666 GO:0022858 alanine transmembrane transporter activity 5/2632 16/18639 0.3125 2.2130271656535 0.0636850801490231 0.588169453893989 GO:0008198 ferrous iron binding 7/2632 26/18639 0.269230769230769 1.90660801963993 0.0637899553866644 0.588169453893989 GO:0002020 protease binding 26/2632 136/18639 0.191176470588235 1.35385191310567 0.0640807187121856 0.588169453893989 GO:0016298 lipase activity 25/2632 130/18639 0.192307692307692 1.36186287117138 0.0645546872102853 0.588317539469622 GO:0005178 integrin binding 30/2632 161/18639 0.186335403726708 1.31956899318469 0.065915017435267 0.596484488762803 GO:0001540 amyloid-beta binding 17/2632 83/18639 0.204819277108434 1.45046599772952 0.0705307086272246 0.633789934167717 GO:0008378 galactosyltransferase activity 8/2632 32/18639 0.25 1.7704217325228 0.0721636405209086 0.643960264370608 GO:0048156 tau protein binding 10/2632 43/18639 0.232558139534884 1.64690393723051 0.0728520221672038 0.645619644723151 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 25/2632 132/18639 0.189393939393939 1.34122858524454 0.074725885194199 0.654294702388595 GO:0015252 proton channel activity 7/2632 27/18639 0.259259259259259 1.83599290780142 0.0760504731718343 0.654294702388595 GO:0004859 phospholipase inhibitor activity 4/2632 12/18639 0.333333333333333 2.36056231003039 0.0768859922651189 0.654294702388595 GO:0016423 tRNA (guanine) methyltransferase activity 4/2632 12/18639 0.333333333333333 2.36056231003039 0.0768859922651189 0.654294702388595 GO:0016840 carbon-nitrogen lyase activity 4/2632 12/18639 0.333333333333333 2.36056231003039 0.0768859922651189 0.654294702388595 GO:0097371 MDM2/MDM4 family protein binding 4/2632 12/18639 0.333333333333333 2.36056231003039 0.0768859922651189 0.654294702388595 GO:0034062 5'-3' RNA polymerase activity 6/2632 22/18639 0.272727272727273 1.93136916275214 0.0790573976427904 0.659667246564842 GO:0061133 endopeptidase activator activity 6/2632 22/18639 0.272727272727273 1.93136916275214 0.0790573976427904 0.659667246564842 GO:0097747 RNA polymerase activity 6/2632 22/18639 0.272727272727273 1.93136916275214 0.0790573976427904 0.659667246564842 GO:0008429 phosphatidylethanolamine binding 5/2632 17/18639 0.294117647058824 2.08284909708564 0.0801198445052359 0.659961539674539 GO:0032977 membrane insertase activity 5/2632 17/18639 0.294117647058824 2.08284909708564 0.0801198445052359 0.659961539674539 GO:0016790 thiolester hydrolase activity 10/2632 44/18639 0.227272727272727 1.60947430229345 0.0828846542897492 0.678387138613552 GO:0046625 sphingolipid binding 7/2632 28/18639 0.25 1.7704217325228 0.0895907396702807 0.72016644109137 GO:0097718 disordered domain specific binding 7/2632 28/18639 0.25 1.7704217325228 0.0895907396702807 0.72016644109137 GO:0016776 phosphotransferase activity, phosphate group as acceptor 9/2632 39/18639 0.230769230769231 1.63423544540566 0.0896705296300538 0.72016644109137 GO:0032934 sterol binding 14/2632 68/18639 0.205882352941176 1.45799436795995 0.0912777176045245 0.728520913800087 GO:0000295 adenine nucleotide transmembrane transporter activity 6/2632 23/18639 0.260869565217391 1.84739659045857 0.0947433394514436 0.749090953364673 GO:0044325 transmembrane transporter binding 25/2632 136/18639 0.183823529411765 1.30178068567853 0.098223436184165 0.749090953364673 GO:0016854 racemase and epimerase activity 5/2632 18/18639 0.277777777777778 1.96713525835866 0.0985796437084925 0.749090953364673 GO:0030228 lipoprotein particle receptor activity 5/2632 18/18639 0.277777777777778 1.96713525835866 0.0985796437084925 0.749090953364673 GO:1901611 phosphatidylglycerol binding 5/2632 18/18639 0.277777777777778 1.96713525835866 0.0985796437084925 0.749090953364673 GO:0031994 insulin-like growth factor I binding 4/2632 13/18639 0.307692307692308 2.17898059387421 0.0991043659612789 0.749090953364673 GO:0035673 oligopeptide transmembrane transporter activity 4/2632 13/18639 0.307692307692308 2.17898059387421 0.0991043659612789 0.749090953364673 GO:0045159 myosin II binding 4/2632 13/18639 0.307692307692308 2.17898059387421 0.0991043659612789 0.749090953364673 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 4/2632 13/18639 0.307692307692308 2.17898059387421 0.0991043659612789 0.749090953364673 GO:1901682 sulfur compound transmembrane transporter activity 13/2632 63/18639 0.206349206349206 1.46130047763786 0.0996844770625363 0.749090953364673 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 9/2632 40/18639 0.225 1.59337955927052 0.10191488753003 0.761399014395864 GO:0005200 structural constituent of cytoskeleton 21/2632 112/18639 0.1875 1.3278162993921 0.104025420975053 0.766544043035667 GO:0035250 UDP-galactosyltransferase activity 7/2632 29/18639 0.241379310344828 1.70937270726339 0.104393157611861 0.766544043035667 GO:0043236 laminin binding 7/2632 29/18639 0.241379310344828 1.70937270726339 0.104393157611861 0.766544043035667 GO:0030291 protein serine/threonine kinase inhibitor activity 10/2632 46/18639 0.217391304347826 1.53949715871548 0.105351534231202 0.76918591754031 GO:0005080 protein kinase C binding 11/2632 52/18639 0.211538461538462 1.49804915828852 0.107617057904602 0.781287680267873 GO:0030165 PDZ domain binding 16/2632 83/18639 0.192771084337349 1.36514446845131 0.11853693479721 0.854024921396488 GO:0042577 lipid phosphatase activity 5/2632 19/18639 0.263157894736842 1.86360182370821 0.118965339245114 0.854024921396488 GO:0035925 mRNA 3'-UTR AU-rich region binding 7/2632 30/18639 0.233333333333333 1.65239361702128 0.120424470541069 0.859696914695964 GO:0061135 endopeptidase regulator activity 32/2632 184/18639 0.173913043478261 1.23159772697238 0.121752593503915 0.864376147251551 GO:0044548 S100 protein binding 4/2632 14/18639 0.285714285714286 2.0233391228832 0.123912934903001 0.870099023772438 GO:1901612 cardiolipin binding 4/2632 14/18639 0.285714285714286 2.0233391228832 0.123912934903001 0.870099023772438 GO:0003714 transcription corepressor activity 35/2632 204/18639 0.17156862745098 1.21499530663329 0.126139368413897 0.877690276057509 GO:1901981 phosphatidylinositol phosphate binding 32/2632 185/18639 0.172972972972973 1.22494044196172 0.128211714645249 0.877690276057509 GO:0004860 protein kinase inhibitor activity 16/2632 84/18639 0.19047619047619 1.3488927485888 0.128240081331701 0.877690276057509 GO:0004520 DNA endonuclease activity 9/2632 42/18639 0.214285714285714 1.5175043421624 0.129092188462933 0.877690276057509 GO:0008307 structural constituent of muscle 9/2632 42/18639 0.214285714285714 1.5175043421624 0.129092188462933 0.877690276057509 GO:0016859 cis-trans isomerase activity 9/2632 42/18639 0.214285714285714 1.5175043421624 0.129092188462933 0.877690276057509 GO:0004620 phospholipase activity 20/2632 109/18639 0.18348623853211 1.29939209726444 0.12993801673808 0.878791323728593 GO:0003925 G protein activity 11/2632 54/18639 0.203703703703704 1.44256585612969 0.131840928545646 0.88237288115185 GO:0015485 cholesterol binding 11/2632 54/18639 0.203703703703704 1.44256585612969 0.131840928545646 0.88237288115185 GO:0005310 dicarboxylic acid transmembrane transporter activity 7/2632 31/18639 0.225806451612903 1.59909059711736 0.137636874879054 0.883570477619691 GO:0043024 ribosomal small subunit binding 5/2632 20/18639 0.25 1.7704217325228 0.141144143919752 0.883570477619691 GO:0022829 wide pore channel activity 8/2632 37/18639 0.216216216216216 1.53117555245215 0.141750448382494 0.883570477619691 GO:0004521 RNA endonuclease activity 14/2632 73/18639 0.191780821917808 1.35813174001749 0.141902898848811 0.883570477619691 GO:0050840 extracellular matrix binding 13/2632 67/18639 0.194029850746269 1.37405865807739 0.143312299952658 0.883570477619691 GO:0042626 ATPase-coupled transmembrane transporter activity 18/2632 98/18639 0.183673469387755 1.30071800756777 0.143981995859826 0.883570477619691 GO:0001222 transcription corepressor binding 10/2632 49/18639 0.204081632653061 1.44524223063085 0.144925866407045 0.883570477619691 GO:0043178 alcohol binding 17/2632 92/18639 0.184782608695652 1.30857258490815 0.146507813845418 0.883570477619691 GO:0004435 phosphatidylinositol phospholipase C activity 6/2632 26/18639 0.230769230769231 1.63423544540566 0.150692094585205 0.883570477619691 GO:0015216 purine nucleotide transmembrane transporter activity 6/2632 26/18639 0.230769230769231 1.63423544540566 0.150692094585205 0.883570477619691 GO:0030247 polysaccharide binding 6/2632 26/18639 0.230769230769231 1.63423544540566 0.150692094585205 0.883570477619691 GO:0070412 R-SMAD binding 6/2632 26/18639 0.230769230769231 1.63423544540566 0.150692094585205 0.883570477619691 GO:0005041 low-density lipoprotein particle receptor activity 4/2632 15/18639 0.266666666666667 1.88844984802432 0.151032288084454 0.883570477619691 GO:0016846 carbon-sulfur lyase activity 4/2632 15/18639 0.266666666666667 1.88844984802432 0.151032288084454 0.883570477619691 GO:0031005 filamin binding 4/2632 15/18639 0.266666666666667 1.88844984802432 0.151032288084454 0.883570477619691 GO:0031386 protein tag activity 4/2632 15/18639 0.266666666666667 1.88844984802432 0.151032288084454 0.883570477619691 GO:0034483 heparan sulfate sulfotransferase activity 4/2632 15/18639 0.266666666666667 1.88844984802432 0.151032288084454 0.883570477619691 GO:0050700 CARD domain binding 4/2632 15/18639 0.266666666666667 1.88844984802432 0.151032288084454 0.883570477619691 GO:0051371 muscle alpha-actinin binding 4/2632 15/18639 0.266666666666667 1.88844984802432 0.151032288084454 0.883570477619691 GO:0141047 molecular tag activity 4/2632 15/18639 0.266666666666667 1.88844984802432 0.151032288084454 0.883570477619691 GO:0031369 translation initiation factor binding 7/2632 32/18639 0.21875 1.54911901595745 0.155969380499335 0.883570477619691 GO:0043425 bHLH transcription factor binding 7/2632 32/18639 0.21875 1.54911901595745 0.155969380499335 0.883570477619691 GO:0004862 cAMP-dependent protein kinase inhibitor activity 3/2632 10/18639 0.3 2.12450607902736 0.157461197957128 0.883570477619691 GO:0004935 adrenergic receptor activity 3/2632 10/18639 0.3 2.12450607902736 0.157461197957128 0.883570477619691 GO:0005345 purine nucleobase transmembrane transporter activity 3/2632 10/18639 0.3 2.12450607902736 0.157461197957128 0.883570477619691 GO:0005528 FK506 binding 3/2632 10/18639 0.3 2.12450607902736 0.157461197957128 0.883570477619691 GO:0008140 cAMP response element binding protein binding 3/2632 10/18639 0.3 2.12450607902736 0.157461197957128 0.883570477619691 GO:0008190 eukaryotic initiation factor 4E binding 3/2632 10/18639 0.3 2.12450607902736 0.157461197957128 0.883570477619691 GO:0008239 dipeptidyl-peptidase activity 3/2632 10/18639 0.3 2.12450607902736 0.157461197957128 0.883570477619691 GO:0015203 polyamine transmembrane transporter activity 3/2632 10/18639 0.3 2.12450607902736 0.157461197957128 0.883570477619691 GO:0016868 intramolecular phosphotransferase activity 3/2632 10/18639 0.3 2.12450607902736 0.157461197957128 0.883570477619691 GO:0019531 oxalate transmembrane transporter activity 3/2632 10/18639 0.3 2.12450607902736 0.157461197957128 0.883570477619691 GO:0031419 cobalamin binding 3/2632 10/18639 0.3 2.12450607902736 0.157461197957128 0.883570477619691 GO:0031957 very long-chain fatty acid-CoA ligase activity 3/2632 10/18639 0.3 2.12450607902736 0.157461197957128 0.883570477619691 GO:0033204 ribonuclease P RNA binding 3/2632 10/18639 0.3 2.12450607902736 0.157461197957128 0.883570477619691 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 3/2632 10/18639 0.3 2.12450607902736 0.157461197957128 0.883570477619691 GO:0098505 G-rich strand telomeric DNA binding 3/2632 10/18639 0.3 2.12450607902736 0.157461197957128 0.883570477619691 GO:0005109 frizzled binding 8/2632 38/18639 0.210526315789474 1.49088145896657 0.158659905461887 0.886425993558802 GO:0046906 tetrapyrrole binding 26/2632 152/18639 0.171052631578947 1.21134118541033 0.171614869877691 0.948684462186558 GO:0008320 protein transmembrane transporter activity 6/2632 27/18639 0.222222222222222 1.57370820668693 0.172018272131882 0.948684462186558 GO:0023026 MHC class II protein complex binding 6/2632 27/18639 0.222222222222222 1.57370820668693 0.172018272131882 0.948684462186558 GO:0030544 Hsp70 protein binding 10/2632 51/18639 0.196078431372549 1.38856606472376 0.17498666856545 0.960829431058706 GO:0035091 phosphatidylinositol binding 46/2632 284/18639 0.161971830985915 1.1470337985359 0.176220327348429 0.960829431058706 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 8/2632 39/18639 0.205128205128205 1.45265372924947 0.176463615353972 0.960829431058706 GO:0016722 oxidoreductase activity, acting on metal ions 4/2632 16/18639 0.25 1.7704217325228 0.180148024062931 0.96454254550361 GO:0022841 potassium ion leak channel activity 4/2632 16/18639 0.25 1.7704217325228 0.180148024062931 0.96454254550361 GO:0055102 lipase inhibitor activity 4/2632 16/18639 0.25 1.7704217325228 0.180148024062931 0.96454254550361 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 4/2632 16/18639 0.25 1.7704217325228 0.180148024062931 0.96454254550361 GO:0097110 scaffold protein binding 13/2632 70/18639 0.185714285714286 1.31517042987408 0.181778825694094 0.969235647373074 GO:0004536 DNA nuclease activity 12/2632 64/18639 0.1875 1.3278162993921 0.185078286199238 0.982750403991822 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 6/2632 28/18639 0.214285714285714 1.5175043421624 0.194498508257773 0.988937982128006 GO:0003953 NAD+ nucleosidase activity 3/2632 11/18639 0.272727272727273 1.93136916275214 0.194952266562867 0.988937982128006 GO:0005114 type II transforming growth factor beta receptor binding 3/2632 11/18639 0.272727272727273 1.93136916275214 0.194952266562867 0.988937982128006 GO:0010854 adenylate cyclase regulator activity 3/2632 11/18639 0.272727272727273 1.93136916275214 0.194952266562867 0.988937982128006 GO:0015205 nucleobase transmembrane transporter activity 3/2632 11/18639 0.272727272727273 1.93136916275214 0.194952266562867 0.988937982128006 GO:0032050 clathrin heavy chain binding 3/2632 11/18639 0.272727272727273 1.93136916275214 0.194952266562867 0.988937982128006 GO:0035252 UDP-xylosyltransferase activity 3/2632 11/18639 0.272727272727273 1.93136916275214 0.194952266562867 0.988937982128006 GO:0042285 xylosyltransferase activity 3/2632 11/18639 0.272727272727273 1.93136916275214 0.194952266562867 0.988937982128006 GO:0043522 leucine zipper domain binding 3/2632 11/18639 0.272727272727273 1.93136916275214 0.194952266562867 0.988937982128006 GO:0070990 snRNP binding 3/2632 11/18639 0.272727272727273 1.93136916275214 0.194952266562867 0.988937982128006 GO:0180030 inositol phosphate kinase activity 3/2632 11/18639 0.272727272727273 1.93136916275214 0.194952266562867 0.988937982128006 GO:0019210 kinase inhibitor activity 16/2632 90/18639 0.177777777777778 1.25896656534954 0.195478791798065 0.988937982128006 GO:0140296 general transcription initiation factor binding 10/2632 53/18639 0.188679245283019 1.33616734530022 0.20768836643601 1 GO:1901505 carbohydrate derivative transmembrane transporter activity 10/2632 53/18639 0.188679245283019 1.33616734530022 0.20768836643601 1 GO:0004518 nuclease activity 34/2632 209/18639 0.162679425837321 1.15204476374689 0.210346443298876 1 GO:0004549 tRNA-specific ribonuclease activity 4/2632 17/18639 0.235294117647059 1.66627927766851 0.210925925465299 1 GO:0004550 nucleoside diphosphate kinase activity 4/2632 17/18639 0.235294117647059 1.66627927766851 0.210925925465299 1 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 4/2632 17/18639 0.235294117647059 1.66627927766851 0.210925925465299 1 GO:0019198 transmembrane receptor protein phosphatase activity 4/2632 17/18639 0.235294117647059 1.66627927766851 0.210925925465299 1 GO:0048038 quinone binding 4/2632 17/18639 0.235294117647059 1.66627927766851 0.210925925465299 1 GO:0070402 NADPH binding 4/2632 17/18639 0.235294117647059 1.66627927766851 0.210925925465299 1 GO:0070492 oligosaccharide binding 4/2632 17/18639 0.235294117647059 1.66627927766851 0.210925925465299 1 GO:1990226 histone methyltransferase binding 4/2632 17/18639 0.235294117647059 1.66627927766851 0.210925925465299 1 GO:0140102 catalytic activity, acting on a rRNA 5/2632 23/18639 0.217391304347826 1.53949715871548 0.216741791825686 1 GO:0003785 actin monomer binding 6/2632 29/18639 0.206896551724138 1.46517660622576 0.218004251904533 1 GO:0004629 phospholipase C activity 6/2632 29/18639 0.206896551724138 1.46517660622576 0.218004251904533 1 GO:0052689 carboxylic ester hydrolase activity 16/2632 92/18639 0.173913043478261 1.23159772697238 0.221046000283007 1 GO:0017069 snRNA binding 10/2632 54/18639 0.185185185185185 1.31142350557244 0.224926420502002 1 GO:0051287 NAD binding 10/2632 54/18639 0.185185185185185 1.31142350557244 0.224926420502002 1 GO:0003995 acyl-CoA dehydrogenase activity 3/2632 12/18639 0.25 1.7704217325228 0.234307691328782 1 GO:0004526 ribonuclease P activity 3/2632 12/18639 0.25 1.7704217325228 0.234307691328782 1 GO:0005527 macrolide binding 3/2632 12/18639 0.25 1.7704217325228 0.234307691328782 1 GO:0008179 adenylate cyclase binding 3/2632 12/18639 0.25 1.7704217325228 0.234307691328782 1 GO:0008603 cAMP-dependent protein kinase regulator activity 3/2632 12/18639 0.25 1.7704217325228 0.234307691328782 1 GO:0016208 AMP binding 3/2632 12/18639 0.25 1.7704217325228 0.234307691328782 1 GO:0017166 vinculin binding 3/2632 12/18639 0.25 1.7704217325228 0.234307691328782 1 GO:0031543 peptidyl-proline dioxygenase activity 3/2632 12/18639 0.25 1.7704217325228 0.234307691328782 1 GO:0043047 single-stranded telomeric DNA binding 3/2632 12/18639 0.25 1.7704217325228 0.234307691328782 1 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 3/2632 12/18639 0.25 1.7704217325228 0.234307691328782 1 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 3/2632 12/18639 0.25 1.7704217325228 0.234307691328782 1 GO:0140829 bicarbonate:monoatomic anion antiporter activity 3/2632 12/18639 0.25 1.7704217325228 0.234307691328782 1 GO:0140900 chloride:bicarbonate antiporter activity 3/2632 12/18639 0.25 1.7704217325228 0.234307691328782 1 GO:0051879 Hsp90 protein binding 8/2632 42/18639 0.19047619047619 1.3488927485888 0.234601125799454 1 GO:0008201 heparin binding 28/2632 172/18639 0.162790697674419 1.15283275606136 0.235903233684389 1 GO:0005484 SNAP receptor activity 7/2632 36/18639 0.194444444444444 1.37699468085106 0.238908663236815 1 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 7/2632 36/18639 0.194444444444444 1.37699468085106 0.238908663236815 1 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 7/2632 36/18639 0.194444444444444 1.37699468085106 0.238908663236815 1 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 7/2632 36/18639 0.194444444444444 1.37699468085106 0.238908663236815 1 GO:0003684 damaged DNA binding 13/2632 74/18639 0.175675675675676 1.24408013636737 0.239777416174274 1 GO:0016791 phosphatase activity 43/2632 273/18639 0.157509157509158 1.11543054210227 0.241288241982963 1 GO:0015215 nucleotide transmembrane transporter activity 6/2632 30/18639 0.2 1.41633738601824 0.242399197245399 1 GO:0035615 clathrin adaptor activity 4/2632 18/18639 0.222222222222222 1.57370820668693 0.2430248631101 1 GO:0070628 proteasome binding 4/2632 18/18639 0.222222222222222 1.57370820668693 0.2430248631101 1 GO:0042625 ATPase-coupled ion transmembrane transporter activity 5/2632 24/18639 0.208333333333333 1.475351443769 0.24431616552533 1 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 5/2632 24/18639 0.208333333333333 1.475351443769 0.24431616552533 1 GO:0046961 proton-transporting ATPase activity, rotational mechanism 5/2632 24/18639 0.208333333333333 1.475351443769 0.24431616552533 1 GO:0050431 transforming growth factor beta binding 5/2632 24/18639 0.208333333333333 1.475351443769 0.24431616552533 1 GO:0140612 DNA damage sensor activity 5/2632 24/18639 0.208333333333333 1.475351443769 0.24431616552533 1 GO:0140030 modification-dependent protein binding 28/2632 173/18639 0.161849710982659 1.14616898290493 0.245846106293669 1 GO:0035254 glutamate receptor binding 9/2632 49/18639 0.183673469387755 1.30071800756777 0.248979692495747 1 GO:0004866 endopeptidase inhibitor activity 26/2632 161/18639 0.161490683229814 1.14362646076007 0.259581444047072 1 GO:0019212 phosphatase inhibitor activity 10/2632 56/18639 0.178571428571429 1.264586951802 0.26094000313106 1 GO:0019213 deacetylase activity 7/2632 37/18639 0.189189189189189 1.33977860839563 0.261578913369489 1 GO:0023023 MHC protein complex binding 7/2632 37/18639 0.189189189189189 1.33977860839563 0.261578913369489 1 GO:0072349 modified amino acid transmembrane transporter activity 6/2632 31/18639 0.193548387096774 1.37064908324346 0.267542154613321 1 GO:0008083 growth factor activity 26/2632 162/18639 0.160493827160494 1.13656703816278 0.270359950753572 1 GO:0003712 transcription coregulator activity 75/2632 495/18639 0.151515151515152 1.07298286819563 0.270487968112021 1 GO:0020037 heme binding 23/2632 142/18639 0.161971830985915 1.1470337985359 0.270725364811158 1 GO:0005507 copper ion binding 11/2632 63/18639 0.174603174603175 1.23648501953973 0.271072447301167 1 GO:0000030 mannosyltransferase activity 5/2632 25/18639 0.2 1.41633738601824 0.272735768214123 1 GO:0015271 outward rectifier potassium channel activity 5/2632 25/18639 0.2 1.41633738601824 0.272735768214123 1 GO:0030414 peptidase inhibitor activity 27/2632 169/18639 0.159763313609467 1.13139376989622 0.27362948311444 1 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 3/2632 13/18639 0.230769230769231 1.63423544540566 0.274868688939033 1 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 3/2632 13/18639 0.230769230769231 1.63423544540566 0.274868688939033 1 GO:0005035 death receptor activity 3/2632 13/18639 0.230769230769231 1.63423544540566 0.274868688939033 1 GO:0005172 vascular endothelial growth factor receptor binding 3/2632 13/18639 0.230769230769231 1.63423544540566 0.274868688939033 1 GO:0008253 5'-nucleotidase activity 3/2632 13/18639 0.230769230769231 1.63423544540566 0.274868688939033 1 GO:0019104 DNA N-glycosylase activity 3/2632 13/18639 0.230769230769231 1.63423544540566 0.274868688939033 1 GO:0043560 insulin receptor substrate binding 3/2632 13/18639 0.230769230769231 1.63423544540566 0.274868688939033 1 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 4/2632 19/18639 0.210526315789474 1.49088145896657 0.276107402807431 1 GO:0022840 leak channel activity 4/2632 19/18639 0.210526315789474 1.49088145896657 0.276107402807431 1 GO:0022842 narrow pore channel activity 4/2632 19/18639 0.210526315789474 1.49088145896657 0.276107402807431 1 GO:0097001 ceramide binding 4/2632 19/18639 0.210526315789474 1.49088145896657 0.276107402807431 1 GO:0016248 channel inhibitor activity 8/2632 44/18639 0.181818181818182 1.28757944183476 0.276564765112748 1 GO:0019205 nucleobase-containing compound kinase activity 8/2632 44/18639 0.181818181818182 1.28757944183476 0.276564765112748 1 GO:0030020 extracellular matrix structural constituent conferring tensile strength 8/2632 44/18639 0.181818181818182 1.28757944183476 0.276564765112748 1 GO:0043531 ADP binding 7/2632 38/18639 0.184210526315789 1.30452127659574 0.284818689348626 1 GO:0022884 macromolecule transmembrane transporter activity 6/2632 32/18639 0.1875 1.3278162993921 0.293289717870395 1 GO:0051059 NF-kappaB binding 6/2632 32/18639 0.1875 1.3278162993921 0.293289717870395 1 GO:0019903 protein phosphatase binding 23/2632 144/18639 0.159722222222222 1.13110277355623 0.294340839879717 1 GO:0141110 transporter inhibitor activity 8/2632 45/18639 0.177777777777778 1.25896656534954 0.298269145410384 1 GO:0016887 ATP hydrolysis activity 63/2632 417/18639 0.151079136690647 1.06989514771162 0.299408620625864 1 GO:0005160 transforming growth factor beta receptor binding 5/2632 26/18639 0.192307692307692 1.36186287117138 0.301793785744817 1 GO:0120014 phospholipid transfer activity 5/2632 26/18639 0.192307692307692 1.36186287117138 0.301793785744817 1 GO:0160215 deacylase activity 11/2632 65/18639 0.169230769230769 1.19843932663082 0.307088527915016 1 GO:0030159 signaling receptor complex adaptor activity 9/2632 52/18639 0.173076923076923 1.22567658405424 0.309091806298928 1 GO:0010851 cyclase regulator activity 4/2632 20/18639 0.2 1.41633738601824 0.30984821752935 1 GO:0030742 GTP-dependent protein binding 4/2632 20/18639 0.2 1.41633738601824 0.30984821752935 1 GO:0140664 ATP-dependent DNA damage sensor activity 4/2632 20/18639 0.2 1.41633738601824 0.30984821752935 1 GO:0005518 collagen binding 12/2632 72/18639 0.166666666666667 1.1802811550152 0.314306920555686 1 GO:0005161 platelet-derived growth factor receptor binding 3/2632 14/18639 0.214285714285714 1.5175043421624 0.31603844003977 1 GO:0005545 1-phosphatidylinositol binding 3/2632 14/18639 0.214285714285714 1.5175043421624 0.31603844003977 1 GO:0008174 mRNA methyltransferase activity 3/2632 14/18639 0.214285714285714 1.5175043421624 0.31603844003977 1 GO:0008474 palmitoyl-(protein) hydrolase activity 3/2632 14/18639 0.214285714285714 1.5175043421624 0.31603844003977 1 GO:0016530 metallochaperone activity 3/2632 14/18639 0.214285714285714 1.5175043421624 0.31603844003977 1 GO:0030983 mismatched DNA binding 3/2632 14/18639 0.214285714285714 1.5175043421624 0.31603844003977 1 GO:0031404 chloride ion binding 3/2632 14/18639 0.214285714285714 1.5175043421624 0.31603844003977 1 GO:0032036 myosin heavy chain binding 3/2632 14/18639 0.214285714285714 1.5175043421624 0.31603844003977 1 GO:0042813 Wnt receptor activity 3/2632 14/18639 0.214285714285714 1.5175043421624 0.31603844003977 1 GO:0070742 C2H2 zinc finger domain binding 3/2632 14/18639 0.214285714285714 1.5175043421624 0.31603844003977 1 GO:0098599 palmitoyl hydrolase activity 3/2632 14/18639 0.214285714285714 1.5175043421624 0.31603844003977 1 GO:0098847 sequence-specific single stranded DNA binding 3/2632 14/18639 0.214285714285714 1.5175043421624 0.31603844003977 1 GO:0015459 potassium channel regulator activity 10/2632 59/18639 0.169491525423729 1.20028592035444 0.318019913519775 1 GO:0045309 protein phosphorylated amino acid binding 10/2632 59/18639 0.169491525423729 1.20028592035444 0.318019913519775 1 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 6/2632 33/18639 0.181818181818182 1.28757944183476 0.319498687153483 1 GO:0140416 transcription regulator inhibitor activity 6/2632 33/18639 0.181818181818182 1.28757944183476 0.319498687153483 1 GO:0005539 glycosaminoglycan binding 37/2632 242/18639 0.152892561983471 1.0827372579065 0.326399028470321 1 GO:0016874 ligase activity 26/2632 167/18639 0.155688622754491 1.10253808492438 0.326589133135461 1 GO:0140104 molecular carrier activity 38/2632 249/18639 0.152610441767068 1.08073937085729 0.327882677965949 1 GO:0004864 protein phosphatase inhibitor activity 9/2632 53/18639 0.169811320754717 1.2025506107702 0.329833418998161 1 GO:0051219 phosphoprotein binding 15/2632 93/18639 0.161290322580645 1.14220756936955 0.330905537359227 1 GO:0001671 ATPase activator activity 5/2632 27/18639 0.185185185185185 1.31142350557244 0.331288220656848 1 GO:0035255 ionotropic glutamate receptor binding 5/2632 27/18639 0.185185185185185 1.31142350557244 0.331288220656848 1 GO:0061791 GTPase motor activity 7/2632 40/18639 0.175 1.23929521276596 0.332580269400864 1 GO:1990606 membrane scission GTPase motor activity 7/2632 40/18639 0.175 1.23929521276596 0.332580269400864 1 GO:0140597 protein carrier chaperone 29/2632 188/18639 0.154255319148936 1.09238787751407 0.333107167733144 1 GO:0000049 tRNA binding 13/2632 80/18639 0.1625 1.15077412613982 0.337502113127671 1 GO:0001784 phosphotyrosine residue binding 8/2632 47/18639 0.170212765957447 1.20539352001552 0.342707526222119 1 GO:0005504 fatty acid binding 8/2632 47/18639 0.170212765957447 1.20539352001552 0.342707526222119 1 GO:0000287 magnesium ion binding 35/2632 230/18639 0.152173913043478 1.07764801110083 0.343108526600003 1 GO:0019200 carbohydrate kinase activity 4/2632 21/18639 0.19047619047619 1.3488927485888 0.343940486856901 1 GO:0070182 DNA polymerase binding 4/2632 21/18639 0.19047619047619 1.3488927485888 0.343940486856901 1 GO:0140312 cargo adaptor activity 4/2632 21/18639 0.19047619047619 1.3488927485888 0.343940486856901 1 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 6/2632 34/18639 0.176470588235294 1.24970945825139 0.346028220371923 1 GO:0005496 steroid binding 17/2632 108/18639 0.157407407407407 1.11470997973658 0.353888769656378 1 GO:0001618 virus receptor activity 13/2632 81/18639 0.160493827160494 1.13656703816278 0.354614583614786 1 GO:0061650 ubiquitin-like protein conjugating enzyme activity 7/2632 41/18639 0.170731707317073 1.20906850025947 0.35689005141043 1 GO:0140318 protein transporter activity 7/2632 41/18639 0.170731707317073 1.20906850025947 0.35689005141043 1 GO:0000774 adenyl-nucleotide exchange factor activity 3/2632 15/18639 0.2 1.41633738601824 0.357289978028598 1 GO:0004865 protein serine/threonine phosphatase inhibitor activity 3/2632 15/18639 0.2 1.41633738601824 0.357289978028598 1 GO:0005523 tropomyosin binding 3/2632 15/18639 0.2 1.41633738601824 0.357289978028598 1 GO:0008252 nucleotidase activity 3/2632 15/18639 0.2 1.41633738601824 0.357289978028598 1 GO:0010181 FMN binding 3/2632 15/18639 0.2 1.41633738601824 0.357289978028598 1 GO:0015116 sulfate transmembrane transporter activity 3/2632 15/18639 0.2 1.41633738601824 0.357289978028598 1 GO:0048531 beta-1,3-galactosyltransferase activity 3/2632 15/18639 0.2 1.41633738601824 0.357289978028598 1 GO:0140161 monocarboxylate:sodium symporter activity 3/2632 15/18639 0.2 1.41633738601824 0.357289978028598 1 GO:0030246 carbohydrate binding 42/2632 280/18639 0.15 1.06225303951368 0.360626595161948 1 GO:0019789 SUMO transferase activity 5/2632 28/18639 0.178571428571429 1.264586951802 0.361025114656647 1 GO:0051393 alpha-actinin binding 5/2632 28/18639 0.178571428571429 1.264586951802 0.361025114656647 1 GO:0004867 serine-type endopeptidase inhibitor activity 15/2632 95/18639 0.157894736842105 1.11816109422492 0.362542948896208 1 GO:0016879 ligase activity, forming carbon-nitrogen bonds 8/2632 48/18639 0.166666666666667 1.1802811550152 0.365275478415549 1 GO:0032266 phosphatidylinositol-3-phosphate binding 8/2632 48/18639 0.166666666666667 1.1802811550152 0.365275478415549 1 GO:0019003 GDP binding 12/2632 75/18639 0.16 1.13306990881459 0.367784024891053 1 GO:0016757 glycosyltransferase activity 40/2632 267/18639 0.149812734082397 1.06092688091254 0.368256850436864 1 GO:0140272 exogenous protein binding 13/2632 82/18639 0.158536585365854 1.12270646452665 0.371868136545296 1 GO:0140313 molecular sequestering activity 9/2632 55/18639 0.163636363636364 1.15882149765128 0.371968946626595 1 GO:0008649 rRNA methyltransferase activity 4/2632 22/18639 0.181818181818182 1.28757944183476 0.378100508572737 1 GO:0008970 phospholipase A1 activity 4/2632 22/18639 0.181818181818182 1.28757944183476 0.378100508572737 1 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 4/2632 22/18639 0.181818181818182 1.28757944183476 0.378100508572737 1 GO:0016881 acid-amino acid ligase activity 4/2632 22/18639 0.181818181818182 1.28757944183476 0.378100508572737 1 GO:0031683 G-protein beta/gamma-subunit complex binding 4/2632 22/18639 0.181818181818182 1.28757944183476 0.378100508572737 1 GO:0070034 telomerase RNA binding 4/2632 22/18639 0.181818181818182 1.28757944183476 0.378100508572737 1 GO:0140517 protein-RNA adaptor activity 4/2632 22/18639 0.181818181818182 1.28757944183476 0.378100508572737 1 GO:0042056 chemoattractant activity 7/2632 42/18639 0.166666666666667 1.1802811550152 0.381347836532625 1 GO:0017022 myosin binding 12/2632 76/18639 0.157894736842105 1.11816109422492 0.385897750876886 1 GO:0016763 pentosyltransferase activity 8/2632 49/18639 0.163265306122449 1.15619378450468 0.387967339082828 1 GO:0060590 ATPase regulator activity 8/2632 49/18639 0.163265306122449 1.15619378450468 0.387967339082828 1 GO:0005416 amino acid:monoatomic cation symporter activity 5/2632 29/18639 0.172413793103448 1.22098050518814 0.390821127730005 1 GO:0051861 glycolipid binding 5/2632 29/18639 0.172413793103448 1.22098050518814 0.390821127730005 1 GO:0005159 insulin-like growth factor receptor binding 3/2632 16/18639 0.1875 1.3278162993921 0.398168890482214 1 GO:0015562 efflux transmembrane transporter activity 3/2632 16/18639 0.1875 1.3278162993921 0.398168890482214 1 GO:0017070 U6 snRNA binding 3/2632 16/18639 0.1875 1.3278162993921 0.398168890482214 1 GO:0019841 retinol binding 3/2632 16/18639 0.1875 1.3278162993921 0.398168890482214 1 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity 3/2632 16/18639 0.1875 1.3278162993921 0.398168890482214 1 GO:0030275 LRR domain binding 3/2632 16/18639 0.1875 1.3278162993921 0.398168890482214 1 GO:0043023 ribosomal large subunit binding 3/2632 16/18639 0.1875 1.3278162993921 0.398168890482214 1 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 3/2632 16/18639 0.1875 1.3278162993921 0.398168890482214 1 GO:0097027 ubiquitin-protein transferase activator activity 3/2632 16/18639 0.1875 1.3278162993921 0.398168890482214 1 GO:0045505 dynein intermediate chain binding 6/2632 36/18639 0.166666666666667 1.1802811550152 0.399508306503436 1 GO:0003724 RNA helicase activity 12/2632 77/18639 0.155844155844156 1.10363952157265 0.404087634091884 1 GO:0008200 ion channel inhibitor activity 7/2632 43/18639 0.162790697674419 1.15283275606136 0.405854282086584 1 GO:0003689 DNA clamp loader activity 24/2632 160/18639 0.15 1.06225303951368 0.408168830741466 1 GO:0140297 DNA-binding transcription factor binding 71/2632 488/18639 0.145491803278689 1.03032740171409 0.411512983400488 1 GO:0004022 alcohol dehydrogenase (NAD+) activity 4/2632 23/18639 0.173913043478261 1.23159772697238 0.412070764730011 1 GO:0005283 amino acid:sodium symporter activity 4/2632 23/18639 0.173913043478261 1.23159772697238 0.412070764730011 1 GO:0008171 O-methyltransferase activity 4/2632 23/18639 0.173913043478261 1.23159772697238 0.412070764730011 1 GO:0016849 phosphorus-oxygen lyase activity 4/2632 23/18639 0.173913043478261 1.23159772697238 0.412070764730011 1 GO:0140103 catalytic activity, acting on a glycoprotein 4/2632 23/18639 0.173913043478261 1.23159772697238 0.412070764730011 1 GO:0140299 molecular sensor activity 11/2632 71/18639 0.154929577464789 1.09716276381694 0.420180478690307 1 GO:0001965 G-protein alpha-subunit binding 5/2632 30/18639 0.166666666666667 1.1802811550152 0.420505513826926 1 GO:0000182 rDNA binding 2/2632 10/18639 0.2 1.41633738601824 0.423020558054582 1 GO:0001094 TFIID-class transcription factor complex binding 2/2632 10/18639 0.2 1.41633738601824 0.423020558054582 1 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 2/2632 10/18639 0.2 1.41633738601824 0.423020558054582 1 GO:0004955 prostaglandin receptor activity 2/2632 10/18639 0.2 1.41633738601824 0.423020558054582 1 GO:0005031 tumor necrosis factor receptor activity 2/2632 10/18639 0.2 1.41633738601824 0.423020558054582 1 GO:0015187 glycine transmembrane transporter activity 2/2632 10/18639 0.2 1.41633738601824 0.423020558054582 1 GO:0015279 store-operated calcium channel activity 2/2632 10/18639 0.2 1.41633738601824 0.423020558054582 1 GO:0015643 toxic substance binding 2/2632 10/18639 0.2 1.41633738601824 0.423020558054582 1 GO:0016175 superoxide-generating NAD(P)H oxidase activity 2/2632 10/18639 0.2 1.41633738601824 0.423020558054582 1 GO:0019911 structural constituent of myelin sheath 2/2632 10/18639 0.2 1.41633738601824 0.423020558054582 1 GO:0030957 Tat protein binding 2/2632 10/18639 0.2 1.41633738601824 0.423020558054582 1 GO:0031434 mitogen-activated protein kinase kinase binding 2/2632 10/18639 0.2 1.41633738601824 0.423020558054582 1 GO:0031996 thioesterase binding 2/2632 10/18639 0.2 1.41633738601824 0.423020558054582 1 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 2/2632 10/18639 0.2 1.41633738601824 0.423020558054582 1 GO:0035256 G protein-coupled glutamate receptor binding 2/2632 10/18639 0.2 1.41633738601824 0.423020558054582 1 GO:0035374 chondroitin sulfate binding 2/2632 10/18639 0.2 1.41633738601824 0.423020558054582 1 GO:0043422 protein kinase B binding 2/2632 10/18639 0.2 1.41633738601824 0.423020558054582 1 GO:0050815 phosphoserine residue binding 2/2632 10/18639 0.2 1.41633738601824 0.423020558054582 1 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 2/2632 10/18639 0.2 1.41633738601824 0.423020558054582 1 GO:1990757 ubiquitin ligase activator activity 2/2632 10/18639 0.2 1.41633738601824 0.423020558054582 1 GO:0042805 actinin binding 6/2632 37/18639 0.162162162162162 1.14838166433911 0.426204318077749 1 GO:0038024 cargo receptor activity 10/2632 65/18639 0.153846153846154 1.08949029693711 0.437727605167463 1 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 3/2632 17/18639 0.176470588235294 1.24970945825139 0.438292382985839 1 GO:0017110 nucleoside diphosphate phosphatase activity 3/2632 17/18639 0.176470588235294 1.24970945825139 0.438292382985839 1 GO:0032183 SUMO binding 3/2632 17/18639 0.176470588235294 1.24970945825139 0.438292382985839 1 GO:0038191 neuropilin binding 3/2632 17/18639 0.176470588235294 1.24970945825139 0.438292382985839 1 GO:0008186 ATP-dependent activity, acting on RNA 12/2632 79/18639 0.151898734177215 1.07569928052018 0.440537147022639 1 GO:0019888 protein phosphatase regulator activity 16/2632 107/18639 0.149532710280374 1.05894384001364 0.443793970407035 1 GO:0004540 RNA nuclease activity 18/2632 121/18639 0.148760330578512 1.0534740887739 0.444741503408313 1 GO:0005315 phosphate transmembrane transporter activity 4/2632 24/18639 0.166666666666667 1.1802811550152 0.445621684570948 1 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 4/2632 24/18639 0.166666666666667 1.1802811550152 0.445621684570948 1 GO:0016878 acid-thiol ligase activity 5/2632 31/18639 0.161290322580645 1.14220756936955 0.449921544444927 1 GO:0017147 Wnt-protein binding 5/2632 31/18639 0.161290322580645 1.14220756936955 0.449921544444927 1 GO:0047499 calcium-independent phospholipase A2 activity 5/2632 31/18639 0.161290322580645 1.14220756936955 0.449921544444927 1 GO:0042162 telomeric DNA binding 6/2632 38/18639 0.157894736842105 1.11816109422492 0.45271412346446 1 GO:0019842 vitamin binding 22/2632 150/18639 0.146666666666667 1.03864741641337 0.45913067619206 1 GO:0035591 signaling adaptor activity 19/2632 129/18639 0.147286821705426 1.04303916024599 0.459407347228621 1 GO:0001221 transcription coregulator binding 17/2632 115/18639 0.147826086956522 1.04685806792652 0.459459246229037 1 GO:0000099 sulfur amino acid transmembrane transporter activity 2/2632 11/18639 0.181818181818182 1.28757944183476 0.473702400608297 1 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 2/2632 11/18639 0.181818181818182 1.28757944183476 0.473702400608297 1 GO:0004016 adenylate cyclase activity 2/2632 11/18639 0.181818181818182 1.28757944183476 0.473702400608297 1 GO:0004954 prostanoid receptor activity 2/2632 11/18639 0.181818181818182 1.28757944183476 0.473702400608297 1 GO:0005225 volume-sensitive anion channel activity 2/2632 11/18639 0.181818181818182 1.28757944183476 0.473702400608297 1 GO:0008172 S-methyltransferase activity 2/2632 11/18639 0.181818181818182 1.28757944183476 0.473702400608297 1 GO:0008199 ferric iron binding 2/2632 11/18639 0.181818181818182 1.28757944183476 0.473702400608297 1 GO:0008271 secondary active sulfate transmembrane transporter activity 2/2632 11/18639 0.181818181818182 1.28757944183476 0.473702400608297 1 GO:0008432 JUN kinase binding 2/2632 11/18639 0.181818181818182 1.28757944183476 0.473702400608297 1 GO:0008526 phosphatidylinositol transfer activity 2/2632 11/18639 0.181818181818182 1.28757944183476 0.473702400608297 1 GO:0015173 aromatic amino acid transmembrane transporter activity 2/2632 11/18639 0.181818181818182 1.28757944183476 0.473702400608297 1 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 2/2632 11/18639 0.181818181818182 1.28757944183476 0.473702400608297 1 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 2/2632 11/18639 0.181818181818182 1.28757944183476 0.473702400608297 1 GO:0019215 intermediate filament binding 2/2632 11/18639 0.181818181818182 1.28757944183476 0.473702400608297 1 GO:0032794 GTPase activating protein binding 2/2632 11/18639 0.181818181818182 1.28757944183476 0.473702400608297 1 GO:0034713 type I transforming growth factor beta receptor binding 2/2632 11/18639 0.181818181818182 1.28757944183476 0.473702400608297 1 GO:0048185 activin binding 2/2632 11/18639 0.181818181818182 1.28757944183476 0.473702400608297 1 GO:0050998 nitric-oxide synthase binding 2/2632 11/18639 0.181818181818182 1.28757944183476 0.473702400608297 1 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 2/2632 11/18639 0.181818181818182 1.28757944183476 0.473702400608297 1 GO:0140031 phosphorylation-dependent protein binding 2/2632 11/18639 0.181818181818182 1.28757944183476 0.473702400608297 1 GO:0140537 transcription regulator activator activity 2/2632 11/18639 0.181818181818182 1.28757944183476 0.473702400608297 1 GO:0048029 monosaccharide binding 11/2632 74/18639 0.148648648648649 1.05268319231085 0.477263080665507 1 GO:0000400 four-way junction DNA binding 3/2632 18/18639 0.166666666666667 1.1802811550152 0.477345886960986 1 GO:0004706 JUN kinase kinase kinase activity 3/2632 18/18639 0.166666666666667 1.1802811550152 0.477345886960986 1 GO:0008308 voltage-gated monoatomic anion channel activity 3/2632 18/18639 0.166666666666667 1.1802811550152 0.477345886960986 1 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 3/2632 18/18639 0.166666666666667 1.1802811550152 0.477345886960986 1 GO:0070064 proline-rich region binding 3/2632 18/18639 0.166666666666667 1.1802811550152 0.477345886960986 1 GO:0098641 cadherin binding involved in cell-cell adhesion 3/2632 18/18639 0.166666666666667 1.1802811550152 0.477345886960986 1 GO:1990381 ubiquitin-specific protease binding 3/2632 18/18639 0.166666666666667 1.1802811550152 0.477345886960986 1 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 10/2632 67/18639 0.149253731343284 1.05696819852107 0.477686542799204 1 GO:0004714 transmembrane receptor protein tyrosine kinase activity 9/2632 60/18639 0.15 1.06225303951368 0.478085974470769 1 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 9/2632 60/18639 0.15 1.06225303951368 0.478085974470769 1 GO:0005544 calcium-dependent phospholipid binding 8/2632 53/18639 0.150943396226415 1.06893387624018 0.478446336227553 1 GO:0038064 collagen receptor activity 8/2632 53/18639 0.150943396226415 1.06893387624018 0.478446336227553 1 GO:0015645 fatty acid ligase activity 4/2632 25/18639 0.16 1.13306990881459 0.478552335305581 1 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 4/2632 25/18639 0.16 1.13306990881459 0.478552335305581 1 GO:0017025 TBP-class protein binding 4/2632 25/18639 0.16 1.13306990881459 0.478552335305581 1 GO:0047617 fatty acyl-CoA hydrolase activity 4/2632 25/18639 0.16 1.13306990881459 0.478552335305581 1 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 4/2632 25/18639 0.16 1.13306990881459 0.478552335305581 1 GO:0120515 fatty acid-CoA ligase activity 4/2632 25/18639 0.16 1.13306990881459 0.478552335305581 1 GO:0031406 carboxylic acid binding 27/2632 187/18639 0.144385026737968 1.02248955675113 0.482197271468129 1 GO:0005267 potassium channel activity 18/2632 124/18639 0.145161290322581 1.02798681243259 0.488753226394886 1 GO:0019208 phosphatase regulator activity 17/2632 117/18639 0.145299145299145 1.02896305821838 0.489631785800283 1 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 13/2632 89/18639 0.146067415730337 1.03440370888972 0.493647038242703 1 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 13/2632 89/18639 0.146067415730337 1.03440370888972 0.493647038242703 1 GO:0004177 aminopeptidase activity 6/2632 40/18639 0.15 1.06225303951368 0.504757586840282 1 GO:0043177 organic acid binding 27/2632 189/18639 0.142857142857143 1.0116695614416 0.505927386228161 1 GO:0016247 channel regulator activity 24/2632 168/18639 0.142857142857143 1.0116695614416 0.509327957661538 1 GO:0004112 cyclic-nucleotide phosphodiesterase activity 4/2632 26/18639 0.153846153846154 1.08949029693711 0.510690253407538 1 GO:0016289 acyl-CoA hydrolase activity 4/2632 26/18639 0.153846153846154 1.08949029693711 0.510690253407538 1 GO:0050750 low-density lipoprotein particle receptor binding 4/2632 26/18639 0.153846153846154 1.08949029693711 0.510690253407538 1 GO:0140793 histone H2AXY142 phosphatase activity 13/2632 90/18639 0.144444444444444 1.0229103343465 0.510788614698156 1 GO:0098631 cell adhesion mediator activity 11/2632 76/18639 0.144736842105263 1.02498100303951 0.514725985184409 1 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 3/2632 19/18639 0.157894736842105 1.11816109422492 0.515078102739777 1 GO:0031420 alkali metal ion binding 3/2632 19/18639 0.157894736842105 1.11816109422492 0.515078102739777 1 GO:0043395 heparan sulfate proteoglycan binding 3/2632 19/18639 0.157894736842105 1.11816109422492 0.515078102739777 1 GO:0046527 glucosyltransferase activity 3/2632 19/18639 0.157894736842105 1.11816109422492 0.515078102739777 1 GO:0120227 acyl-CoA binding 3/2632 19/18639 0.157894736842105 1.11816109422492 0.515078102739777 1 GO:0016758 hexosyltransferase activity 28/2632 197/18639 0.142131979695431 1.00653418295712 0.516469307855268 1 GO:0016279 protein-lysine N-methyltransferase activity 10/2632 69/18639 0.144927536231884 1.02633143914365 0.517017249636563 1 GO:0004875 complement receptor activity 2/2632 12/18639 0.166666666666667 1.1802811550152 0.5215813424642 1 GO:0005049 nuclear export signal receptor activity 2/2632 12/18639 0.166666666666667 1.1802811550152 0.5215813424642 1 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 2/2632 12/18639 0.166666666666667 1.1802811550152 0.5215813424642 1 GO:0008504 monoamine transmembrane transporter activity 2/2632 12/18639 0.166666666666667 1.1802811550152 0.5215813424642 1 GO:0015166 polyol transmembrane transporter activity 2/2632 12/18639 0.166666666666667 1.1802811550152 0.5215813424642 1 GO:0015269 calcium-activated potassium channel activity 2/2632 12/18639 0.166666666666667 1.1802811550152 0.5215813424642 1 GO:0035014 phosphatidylinositol 3-kinase regulator activity 2/2632 12/18639 0.166666666666667 1.1802811550152 0.5215813424642 1 GO:0035259 nuclear glucocorticoid receptor binding 2/2632 12/18639 0.166666666666667 1.1802811550152 0.5215813424642 1 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 2/2632 12/18639 0.166666666666667 1.1802811550152 0.5215813424642 1 GO:0070008 serine-type exopeptidase activity 2/2632 12/18639 0.166666666666667 1.1802811550152 0.5215813424642 1 GO:0070679 inositol 1,4,5 trisphosphate binding 2/2632 12/18639 0.166666666666667 1.1802811550152 0.5215813424642 1 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 2/2632 12/18639 0.166666666666667 1.1802811550152 0.5215813424642 1 GO:0004725 protein tyrosine phosphatase activity 14/2632 98/18639 0.142857142857143 1.0116695614416 0.525445574274982 1 GO:0008170 N-methyltransferase activity 14/2632 98/18639 0.142857142857143 1.0116695614416 0.525445574274982 1 GO:0015175 neutral L-amino acid transmembrane transporter activity 6/2632 41/18639 0.146341463414634 1.03634442879383 0.530106307199685 1 GO:0042169 SH2 domain binding 6/2632 41/18639 0.146341463414634 1.03634442879383 0.530106307199685 1 GO:0141108 transporter regulator activity 24/2632 170/18639 0.141176470588235 0.999767566601109 0.534238325619232 1 GO:0016278 lysine N-methyltransferase activity 10/2632 70/18639 0.142857142857143 1.0116695614416 0.536339858702768 1 GO:0016782 transferase activity, transferring sulphur-containing groups 10/2632 70/18639 0.142857142857143 1.0116695614416 0.536339858702768 1 GO:0004683 calcium/calmodulin-dependent protein kinase activity 4/2632 27/18639 0.148148148148148 1.04913880445795 0.541890606929398 1 GO:0005044 scavenger receptor activity 4/2632 27/18639 0.148148148148148 1.04913880445795 0.541890606929398 1 GO:0016405 CoA-ligase activity 4/2632 27/18639 0.148148148148148 1.04913880445795 0.541890606929398 1 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 4/2632 27/18639 0.148148148148148 1.04913880445795 0.541890606929398 1 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 4/2632 27/18639 0.148148148148148 1.04913880445795 0.541890606929398 1 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 3/2632 20/18639 0.15 1.06225303951368 0.551295141306324 1 GO:0015464 acetylcholine receptor activity 3/2632 20/18639 0.15 1.06225303951368 0.551295141306324 1 GO:0052745 inositol phosphate phosphatase activity 3/2632 20/18639 0.15 1.06225303951368 0.551295141306324 1 GO:0016779 nucleotidyltransferase activity 19/2632 136/18639 0.139705882352941 0.98935332111568 0.557802379461985 1 GO:0004623 phospholipase A2 activity 5/2632 35/18639 0.142857142857143 1.0116695614416 0.562298593298946 1 GO:0005343 organic acid:sodium symporter activity 5/2632 35/18639 0.142857142857143 1.0116695614416 0.562298593298946 1 GO:0016229 steroid dehydrogenase activity 5/2632 35/18639 0.142857142857143 1.0116695614416 0.562298593298946 1 GO:0061631 ubiquitin conjugating enzyme activity 5/2632 35/18639 0.142857142857143 1.0116695614416 0.562298593298946 1 GO:0015932 nucleobase-containing compound transmembrane transporter activity 8/2632 57/18639 0.140350877192982 0.993920972644377 0.565251072860961 1 GO:0004465 lipoprotein lipase activity 2/2632 13/18639 0.153846153846154 1.08949029693711 0.566438188559684 1 GO:0015651 quaternary ammonium group transmembrane transporter activity 2/2632 13/18639 0.153846153846154 1.08949029693711 0.566438188559684 1 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 2/2632 13/18639 0.153846153846154 1.08949029693711 0.566438188559684 1 GO:0017154 semaphorin receptor activity 2/2632 13/18639 0.153846153846154 1.08949029693711 0.566438188559684 1 GO:0030955 potassium ion binding 2/2632 13/18639 0.153846153846154 1.08949029693711 0.566438188559684 1 GO:0039706 co-receptor binding 2/2632 13/18639 0.153846153846154 1.08949029693711 0.566438188559684 1 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 2/2632 13/18639 0.153846153846154 1.08949029693711 0.566438188559684 1 GO:0070700 BMP receptor binding 2/2632 13/18639 0.153846153846154 1.08949029693711 0.566438188559684 1 GO:0097157 pre-mRNA intronic binding 2/2632 13/18639 0.153846153846154 1.08949029693711 0.566438188559684 1 GO:1901338 catecholamine binding 2/2632 13/18639 0.153846153846154 1.08949029693711 0.566438188559684 1 GO:0046332 SMAD binding 11/2632 79/18639 0.139240506329114 0.986057673810165 0.569293362370884 1 GO:0005006 epidermal growth factor receptor activity 7/2632 50/18639 0.14 0.991436170212766 0.571500199363006 1 GO:0015605 organophosphate ester transmembrane transporter activity 7/2632 50/18639 0.14 0.991436170212766 0.571500199363006 1 GO:0050698 proteoglycan sulfotransferase activity 4/2632 28/18639 0.142857142857143 1.0116695614416 0.572034855641522 1 GO:0051019 mitogen-activated protein kinase binding 4/2632 28/18639 0.142857142857143 1.0116695614416 0.572034855641522 1 GO:0016798 hydrolase activity, acting on glycosyl bonds 18/2632 130/18639 0.138461538461538 0.980541267243395 0.574444771136393 1 GO:0008094 ATP-dependent activity, acting on DNA 29/2632 210/18639 0.138095238095238 0.977947242726878 0.58222502510367 1 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 3/2632 21/18639 0.142857142857143 1.0116695614416 0.585854250381228 1 GO:0005123 death receptor binding 3/2632 21/18639 0.142857142857143 1.0116695614416 0.585854250381228 1 GO:0008373 sialyltransferase activity 3/2632 21/18639 0.142857142857143 1.0116695614416 0.585854250381228 1 GO:0009975 cyclase activity 3/2632 21/18639 0.142857142857143 1.0116695614416 0.585854250381228 1 GO:0010314 phosphatidylinositol-5-phosphate binding 3/2632 21/18639 0.142857142857143 1.0116695614416 0.585854250381228 1 GO:0035613 RNA stem-loop binding 3/2632 21/18639 0.142857142857143 1.0116695614416 0.585854250381228 1 GO:0072542 protein phosphatase activator activity 3/2632 21/18639 0.142857142857143 1.0116695614416 0.585854250381228 1 GO:1904047 S-adenosyl-L-methionine binding 3/2632 21/18639 0.142857142857143 1.0116695614416 0.585854250381228 1 GO:0008408 3'-5' exonuclease activity 8/2632 58/18639 0.137931034482759 0.976784404150508 0.585960654032126 1 GO:0048306 calcium-dependent protein binding 11/2632 80/18639 0.1375 0.973731952887538 0.586921031724327 1 GO:0005010 insulin-like growth factor receptor activity 7/2632 51/18639 0.137254901960784 0.971996245306633 0.593468974931109 1 GO:0005021 vascular endothelial growth factor receptor activity 7/2632 51/18639 0.137254901960784 0.971996245306633 0.593468974931109 1 GO:0008276 protein methyltransferase activity 13/2632 95/18639 0.136842105263158 0.969072948328268 0.59364536873449 1 GO:1990782 protein tyrosine kinase binding 16/2632 117/18639 0.136752136752137 0.968435819499649 0.595698044379687 1 GO:0005506 iron ion binding 21/2632 154/18639 0.136363636363636 0.965684581376071 0.604122072443892 1 GO:0004065 arylsulfatase activity 2/2632 14/18639 0.142857142857143 1.0116695614416 0.60817147997967 1 GO:0005313 L-glutamate transmembrane transporter activity 2/2632 14/18639 0.142857142857143 1.0116695614416 0.60817147997967 1 GO:0008331 high voltage-gated calcium channel activity 2/2632 14/18639 0.142857142857143 1.0116695614416 0.60817147997967 1 GO:0015926 glucosidase activity 2/2632 14/18639 0.142857142857143 1.0116695614416 0.60817147997967 1 GO:0019992 diacylglycerol binding 2/2632 14/18639 0.142857142857143 1.0116695614416 0.60817147997967 1 GO:0034236 protein kinase A catalytic subunit binding 2/2632 14/18639 0.142857142857143 1.0116695614416 0.60817147997967 1 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 2/2632 14/18639 0.142857142857143 1.0116695614416 0.60817147997967 1 GO:0042043 neurexin family protein binding 2/2632 14/18639 0.142857142857143 1.0116695614416 0.60817147997967 1 GO:0046030 inositol trisphosphate phosphatase activity 2/2632 14/18639 0.142857142857143 1.0116695614416 0.60817147997967 1 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 2/2632 14/18639 0.142857142857143 1.0116695614416 0.60817147997967 1 GO:0071933 Arp2/3 complex binding 2/2632 14/18639 0.142857142857143 1.0116695614416 0.60817147997967 1 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 2/2632 14/18639 0.142857142857143 1.0116695614416 0.60817147997967 1 GO:1901474 azole transmembrane transporter activity 2/2632 14/18639 0.142857142857143 1.0116695614416 0.60817147997967 1 GO:0004407 histone deacetylase activity 3/2632 22/18639 0.136363636363636 0.965684581376071 0.618657472772042 1 GO:0008093 cytoskeletal anchor activity 3/2632 22/18639 0.136363636363636 0.965684581376071 0.618657472772042 1 GO:0015377 chloride:monoatomic cation symporter activity 3/2632 22/18639 0.136363636363636 0.965684581376071 0.618657472772042 1 GO:0033558 protein lysine deacetylase activity 3/2632 22/18639 0.136363636363636 0.965684581376071 0.618657472772042 1 GO:0140035 ubiquitin-like protein reader activity 3/2632 22/18639 0.136363636363636 0.965684581376071 0.618657472772042 1 GO:0016769 transferase activity, transferring nitrogenous groups 4/2632 30/18639 0.133333333333333 0.944224924012158 0.62880190415051 1 GO:0031210 phosphatidylcholine binding 4/2632 30/18639 0.133333333333333 0.944224924012158 0.62880190415051 1 GO:0048019 receptor antagonist activity 4/2632 30/18639 0.133333333333333 0.944224924012158 0.62880190415051 1 GO:0051721 protein phosphatase 2A binding 4/2632 30/18639 0.133333333333333 0.944224924012158 0.62880190415051 1 GO:0030145 manganese ion binding 9/2632 68/18639 0.132352941176471 0.937282093688539 0.635971931583696 1 GO:1990841 promoter-specific chromatin binding 9/2632 68/18639 0.132352941176471 0.937282093688539 0.635971931583696 1 GO:0140713 histone chaperone activity 22/2632 164/18639 0.134146341463415 0.949982393061013 0.636910906865426 1 GO:0005085 guanyl-nucleotide exchange factor activity 31/2632 230/18639 0.134782608695652 0.954488238403595 0.639631933085273 1 GO:0004467 long-chain fatty acid-CoA ligase activity 2/2632 15/18639 0.133333333333333 0.944224924012158 0.646768634125988 1 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 2/2632 15/18639 0.133333333333333 0.944224924012158 0.646768634125988 1 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 2/2632 15/18639 0.133333333333333 0.944224924012158 0.646768634125988 1 GO:0004953 icosanoid receptor activity 2/2632 15/18639 0.133333333333333 0.944224924012158 0.646768634125988 1 GO:0005402 carbohydrate:monoatomic cation symporter activity 2/2632 15/18639 0.133333333333333 0.944224924012158 0.646768634125988 1 GO:0008242 omega peptidase activity 2/2632 15/18639 0.133333333333333 0.944224924012158 0.646768634125988 1 GO:0015556 C4-dicarboxylate transmembrane transporter activity 2/2632 15/18639 0.133333333333333 0.944224924012158 0.646768634125988 1 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 2/2632 15/18639 0.133333333333333 0.944224924012158 0.646768634125988 1 GO:0017081 chloride channel regulator activity 2/2632 15/18639 0.133333333333333 0.944224924012158 0.646768634125988 1 GO:0033130 acetylcholine receptor binding 2/2632 15/18639 0.133333333333333 0.944224924012158 0.646768634125988 1 GO:0047372 monoacylglycerol lipase activity 2/2632 15/18639 0.133333333333333 0.944224924012158 0.646768634125988 1 GO:0050780 dopamine receptor binding 2/2632 15/18639 0.133333333333333 0.944224924012158 0.646768634125988 1 GO:0061578 K63-linked deubiquitinase activity 2/2632 15/18639 0.133333333333333 0.944224924012158 0.646768634125988 1 GO:0140776 protein-containing complex destabilizing activity 2/2632 15/18639 0.133333333333333 0.944224924012158 0.646768634125988 1 GO:0030276 clathrin binding 6/2632 46/18639 0.130434782608696 0.923698295229285 0.647298532102815 1 GO:0015103 inorganic anion transmembrane transporter activity 22/2632 165/18639 0.133333333333333 0.944224924012158 0.648581397135094 1 GO:0003887 DNA-directed DNA polymerase activity 3/2632 23/18639 0.130434782608696 0.923698295229285 0.649645478978347 1 GO:0005158 insulin receptor binding 3/2632 23/18639 0.130434782608696 0.923698295229285 0.649645478978347 1 GO:0005212 structural constituent of eye lens 3/2632 23/18639 0.130434782608696 0.923698295229285 0.649645478978347 1 GO:0016917 GABA receptor activity 3/2632 23/18639 0.130434782608696 0.923698295229285 0.649645478978347 1 GO:0042171 lysophosphatidic acid acyltransferase activity 3/2632 23/18639 0.130434782608696 0.923698295229285 0.649645478978347 1 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 3/2632 23/18639 0.130434782608696 0.923698295229285 0.649645478978347 1 GO:0071617 lysophospholipid acyltransferase activity 3/2632 23/18639 0.130434782608696 0.923698295229285 0.649645478978347 1 GO:0001664 G protein-coupled receptor binding 40/2632 297/18639 0.134680134680135 0.95376254950723 0.652937421305426 1 GO:0002039 p53 binding 9/2632 69/18639 0.130434782608696 0.923698295229285 0.653815133875766 1 GO:0005452 solute:inorganic anion antiporter activity 4/2632 31/18639 0.129032258064516 0.913766055495637 0.655302698180967 1 GO:0070273 phosphatidylinositol-4-phosphate binding 4/2632 31/18639 0.129032258064516 0.913766055495637 0.655302698180967 1 GO:0070325 lipoprotein particle receptor binding 4/2632 31/18639 0.129032258064516 0.913766055495637 0.655302698180967 1 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 7/2632 54/18639 0.12962962962963 0.917996453900709 0.655709191813366 1 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 7/2632 54/18639 0.12962962962963 0.917996453900709 0.655709191813366 1 GO:0050661 NADP binding 7/2632 54/18639 0.12962962962963 0.917996453900709 0.655709191813366 1 GO:0000510 H3-H4 histone complex chaperone activity 20/2632 151/18639 0.132450331125828 0.937971778820025 0.657083758923509 1 GO:0140584 chromatin extrusion motor activity 20/2632 151/18639 0.132450331125828 0.937971778820025 0.657083758923509 1 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 20/2632 151/18639 0.132450331125828 0.937971778820025 0.657083758923509 1 GO:0140849 ATP-dependent H2AZ histone chaperone activity 20/2632 151/18639 0.132450331125828 0.937971778820025 0.657083758923509 1 GO:0046943 carboxylic acid transmembrane transporter activity 25/2632 188/18639 0.132978723404255 0.941713687512126 0.659254325171544 1 GO:0019955 cytokine binding 19/2632 144/18639 0.131944444444444 0.934389247720365 0.661735979969958 1 GO:0000217 DNA secondary structure binding 5/2632 39/18639 0.128205128205128 0.907908580780921 0.661791558564291 1 GO:0015179 L-amino acid transmembrane transporter activity 8/2632 62/18639 0.129032258064516 0.913766055495637 0.66364057640922 1 GO:0015616 DNA translocase activity 20/2632 152/18639 0.131578947368421 0.931800911854103 0.668944179176848 1 GO:0140674 ATP-dependent histone chaperone activity 20/2632 152/18639 0.131578947368421 0.931800911854103 0.668944179176848 1 GO:0005342 organic acid transmembrane transporter activity 25/2632 189/18639 0.132275132275132 0.936731075408887 0.669897325096852 1 GO:0017124 SH3 domain binding 15/2632 115/18639 0.130434782608696 0.923698295229285 0.670581902940714 1 GO:0008028 monocarboxylic acid transmembrane transporter activity 9/2632 70/18639 0.128571428571429 0.910502605297438 0.671147551524241 1 GO:0008194 UDP-glycosyltransferase activity 19/2632 145/18639 0.131034482758621 0.927945183942983 0.673797938010284 1 GO:0140097 catalytic activity, acting on DNA 45/2632 336/18639 0.133928571428571 0.948440213851498 0.674109161734632 1 GO:0008374 O-acyltransferase activity 7/2632 55/18639 0.127272727272727 0.901305609284333 0.675128953866546 1 GO:0099106 ion channel regulator activity 21/2632 160/18639 0.13125 0.929471409574468 0.675836631456007 1 GO:0051213 dioxygenase activity 12/2632 93/18639 0.129032258064516 0.913766055495637 0.677002092681732 1 GO:0003713 transcription coactivator activity 34/2632 256/18639 0.1328125 0.940536545402736 0.678076564251355 1 GO:0001217 DNA-binding transcription repressor activity 37/2632 278/18639 0.133093525179856 0.942526677745949 0.678125513920001 1 GO:0019199 transmembrane receptor protein kinase activity 10/2632 78/18639 0.128205128205128 0.907908580780921 0.678277220865186 1 GO:0001091 RNA polymerase II general transcription initiation factor binding 3/2632 24/18639 0.125 0.885210866261398 0.678791735322261 1 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 3/2632 24/18639 0.125 0.885210866261398 0.678791735322261 1 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 3/2632 24/18639 0.125 0.885210866261398 0.678791735322261 1 GO:0030552 cAMP binding 3/2632 24/18639 0.125 0.885210866261398 0.678791735322261 1 GO:0035035 histone acetyltransferase binding 3/2632 24/18639 0.125 0.885210866261398 0.678791735322261 1 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 3/2632 24/18639 0.125 0.885210866261398 0.678791735322261 1 GO:0070840 dynein complex binding 3/2632 24/18639 0.125 0.885210866261398 0.678791735322261 1 GO:0015106 bicarbonate transmembrane transporter activity 4/2632 32/18639 0.125 0.885210866261398 0.680499163884673 1 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 4/2632 32/18639 0.125 0.885210866261398 0.680499163884673 1 GO:0047498 calcium-dependent phospholipase A2 activity 4/2632 32/18639 0.125 0.885210866261398 0.680499163884673 1 GO:0070717 poly-purine tract binding 4/2632 32/18639 0.125 0.885210866261398 0.680499163884673 1 GO:0140142 nucleocytoplasmic carrier activity 4/2632 32/18639 0.125 0.885210866261398 0.680499163884673 1 GO:0061775 cohesin loader activity 20/2632 153/18639 0.130718954248366 0.925710709815841 0.68058381299037 1 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 2/2632 16/18639 0.125 0.885210866261398 0.682282883217956 1 GO:0004708 MAP kinase kinase activity 2/2632 16/18639 0.125 0.885210866261398 0.682282883217956 1 GO:0005324 long-chain fatty acid transmembrane transporter activity 2/2632 16/18639 0.125 0.885210866261398 0.682282883217956 1 GO:0008296 3'-5'-DNA exonuclease activity 2/2632 16/18639 0.125 0.885210866261398 0.682282883217956 1 GO:0015378 sodium:chloride symporter activity 2/2632 16/18639 0.125 0.885210866261398 0.682282883217956 1 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 2/2632 16/18639 0.125 0.885210866261398 0.682282883217956 1 GO:0034450 ubiquitin-ubiquitin ligase activity 2/2632 16/18639 0.125 0.885210866261398 0.682282883217956 1 GO:0070411 I-SMAD binding 2/2632 16/18639 0.125 0.885210866261398 0.682282883217956 1 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 2/2632 16/18639 0.125 0.885210866261398 0.682282883217956 1 GO:0015294 solute:monoatomic cation symporter activity 15/2632 116/18639 0.129310344827586 0.915735378891102 0.683857444434634 1 GO:0004532 RNA exonuclease activity 5/2632 40/18639 0.125 0.885210866261398 0.684224983096293 1 GO:0015144 carbohydrate transmembrane transporter activity 5/2632 40/18639 0.125 0.885210866261398 0.684224983096293 1 GO:0030331 nuclear estrogen receptor binding 5/2632 40/18639 0.125 0.885210866261398 0.684224983096293 1 GO:0032451 demethylase activity 5/2632 40/18639 0.125 0.885210866261398 0.684224983096293 1 GO:0050997 quaternary ammonium group binding 5/2632 40/18639 0.125 0.885210866261398 0.684224983096293 1 GO:0071855 neuropeptide receptor binding 5/2632 40/18639 0.125 0.885210866261398 0.684224983096293 1 GO:0071949 FAD binding 5/2632 40/18639 0.125 0.885210866261398 0.684224983096293 1 GO:0042562 hormone binding 12/2632 94/18639 0.127659574468085 0.904045140011641 0.691558009025153 1 GO:0004386 helicase activity 20/2632 155/18639 0.129032258064516 0.913766055495637 0.703174831209474 1 GO:0071889 14-3-3 protein binding 4/2632 33/18639 0.121212121212121 0.858386294556507 0.70437534399365 1 GO:0001530 lipopolysaccharide binding 5/2632 41/18639 0.121951219512195 0.863620357328193 0.705630354748599 1 GO:0016877 ligase activity, forming carbon-sulfur bonds 5/2632 41/18639 0.121951219512195 0.863620357328193 0.705630354748599 1 GO:0017080 sodium channel regulator activity 5/2632 41/18639 0.121951219512195 0.863620357328193 0.705630354748599 1 GO:0003707 nuclear steroid receptor activity 3/2632 25/18639 0.12 0.849802431610942 0.706097108051808 1 GO:0004709 MAP kinase kinase kinase activity 3/2632 25/18639 0.12 0.849802431610942 0.706097108051808 1 GO:0015296 monoatomic anion:monoatomic cation symporter activity 3/2632 25/18639 0.12 0.849802431610942 0.706097108051808 1 GO:0019211 phosphatase activator activity 3/2632 25/18639 0.12 0.849802431610942 0.706097108051808 1 GO:0005004 GPI-linked ephrin receptor activity 6/2632 49/18639 0.122448979591837 0.867145338378512 0.708351783807493 1 GO:0005008 hepatocyte growth factor receptor activity 6/2632 49/18639 0.122448979591837 0.867145338378512 0.708351783807493 1 GO:0005009 insulin receptor activity 6/2632 49/18639 0.122448979591837 0.867145338378512 0.708351783807493 1 GO:0005011 macrophage colony-stimulating factor receptor activity 6/2632 49/18639 0.122448979591837 0.867145338378512 0.708351783807493 1 GO:0005018 platelet-derived growth factor alpha-receptor activity 6/2632 49/18639 0.122448979591837 0.867145338378512 0.708351783807493 1 GO:0005020 stem cell factor receptor activity 6/2632 49/18639 0.122448979591837 0.867145338378512 0.708351783807493 1 GO:0008288 boss receptor activity 6/2632 49/18639 0.122448979591837 0.867145338378512 0.708351783807493 1 GO:0036332 placental growth factor receptor activity 6/2632 49/18639 0.122448979591837 0.867145338378512 0.708351783807493 1 GO:0038062 protein tyrosine kinase collagen receptor activity 6/2632 49/18639 0.122448979591837 0.867145338378512 0.708351783807493 1 GO:0060175 brain-derived neurotrophic factor receptor activity 6/2632 49/18639 0.122448979591837 0.867145338378512 0.708351783807493 1 GO:0005253 monoatomic anion channel activity 13/2632 103/18639 0.12621359223301 0.893805146516363 0.711248768019657 1 GO:0004029 aldehyde dehydrogenase (NAD+) activity 2/2632 17/18639 0.117647058823529 0.833139638834257 0.714814949915572 1 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 2/2632 17/18639 0.117647058823529 0.833139638834257 0.714814949915572 1 GO:0004659 prenyltransferase activity 2/2632 17/18639 0.117647058823529 0.833139638834257 0.714814949915572 1 GO:0005092 GDP-dissociation inhibitor activity 2/2632 17/18639 0.117647058823529 0.833139638834257 0.714814949915572 1 GO:0008484 sulfuric ester hydrolase activity 2/2632 17/18639 0.117647058823529 0.833139638834257 0.714814949915572 1 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 2/2632 17/18639 0.117647058823529 0.833139638834257 0.714814949915572 1 GO:0031489 myosin V binding 2/2632 17/18639 0.117647058823529 0.833139638834257 0.714814949915572 1 GO:0036041 long-chain fatty acid binding 2/2632 17/18639 0.117647058823529 0.833139638834257 0.714814949915572 1 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 35/2632 268/18639 0.130597014925373 0.924847173705938 0.718116469076573 1 GO:0008509 monoatomic anion transmembrane transporter activity 19/2632 149/18639 0.12751677852349 0.903033903837131 0.719620405855621 1 GO:0043539 protein serine/threonine kinase activator activity 9/2632 73/18639 0.123287671232877 0.873084690011242 0.719926738813678 1 GO:0015101 organic cation transmembrane transporter activity 10/2632 81/18639 0.123456790123457 0.874282337048294 0.724190167864336 1 GO:0030971 receptor tyrosine kinase binding 10/2632 81/18639 0.123456790123457 0.874282337048294 0.724190167864336 1 GO:0035198 miRNA binding 5/2632 42/18639 0.119047619047619 0.843057967867998 0.725999404627573 1 GO:0008376 acetylgalactosaminyltransferase activity 4/2632 34/18639 0.117647058823529 0.833139638834257 0.726929518257832 1 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 4/2632 34/18639 0.117647058823529 0.833139638834257 0.726929518257832 1 GO:0030332 cyclin binding 4/2632 34/18639 0.117647058823529 0.833139638834257 0.726929518257832 1 GO:0052866 phosphatidylinositol phosphate phosphatase activity 4/2632 34/18639 0.117647058823529 0.833139638834257 0.726929518257832 1 GO:0090482 vitamin transmembrane transporter activity 4/2632 34/18639 0.117647058823529 0.833139638834257 0.726929518257832 1 GO:0005007 fibroblast growth factor receptor activity 6/2632 50/18639 0.12 0.849802431610942 0.727013363504468 1 GO:0005017 platelet-derived growth factor receptor activity 6/2632 50/18639 0.12 0.849802431610942 0.727013363504468 1 GO:0005019 platelet-derived growth factor beta-receptor activity 6/2632 50/18639 0.12 0.849802431610942 0.727013363504468 1 GO:0017116 single-stranded DNA helicase activity 7/2632 58/18639 0.120689655172414 0.854686353631695 0.729130339420738 1 GO:0008066 glutamate receptor activity 3/2632 26/18639 0.115384615384615 0.817117722702829 0.731584958657582 1 GO:0008143 poly(A) binding 3/2632 26/18639 0.115384615384615 0.817117722702829 0.731584958657582 1 GO:0043548 phosphatidylinositol 3-kinase binding 3/2632 26/18639 0.115384615384615 0.817117722702829 0.731584958657582 1 GO:0050681 nuclear androgen receptor binding 3/2632 26/18639 0.115384615384615 0.817117722702829 0.731584958657582 1 GO:0097602 cullin family protein binding 3/2632 26/18639 0.115384615384615 0.817117722702829 0.731584958657582 1 GO:0035064 methylated histone binding 9/2632 74/18639 0.121621621621622 0.861286248254333 0.735078921889568 1 GO:0140658 ATP-dependent chromatin remodeler activity 20/2632 158/18639 0.126582278481013 0.89641606710015 0.73526178437274 1 GO:0051020 GTPase binding 41/2632 315/18639 0.13015873015873 0.921743378202345 0.738445196167902 1 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 2/2632 18/18639 0.111111111111111 0.786854103343465 0.744498582784895 1 GO:0004970 glutamate-gated receptor activity 2/2632 18/18639 0.111111111111111 0.786854103343465 0.744498582784895 1 GO:0008525 phosphatidylcholine transporter activity 2/2632 18/18639 0.111111111111111 0.786854103343465 0.744498582784895 1 GO:0015172 acidic amino acid transmembrane transporter activity 2/2632 18/18639 0.111111111111111 0.786854103343465 0.744498582784895 1 GO:0015373 monoatomic anion:sodium symporter activity 2/2632 18/18639 0.111111111111111 0.786854103343465 0.744498582784895 1 GO:0017075 syntaxin-1 binding 2/2632 18/18639 0.111111111111111 0.786854103343465 0.744498582784895 1 GO:0022851 GABA-gated chloride ion channel activity 2/2632 18/18639 0.111111111111111 0.786854103343465 0.744498582784895 1 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 2/2632 18/18639 0.111111111111111 0.786854103343465 0.744498582784895 1 GO:0005030 neurotrophin receptor activity 6/2632 51/18639 0.117647058823529 0.833139638834257 0.744819281980916 1 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 5/2632 43/18639 0.116279069767442 0.823451968615254 0.745332370776361 1 GO:0003697 single-stranded DNA binding 15/2632 121/18639 0.12396694214876 0.877895073978246 0.74543565869119 1 GO:0070888 E-box binding 7/2632 59/18639 0.11864406779661 0.840200144248107 0.745680442814636 1 GO:0005249 voltage-gated potassium channel activity 12/2632 98/18639 0.122448979591837 0.867145338378512 0.745708617822696 1 GO:0016500 protein-hormone receptor activity 8/2632 67/18639 0.119402985074627 0.845574558816858 0.747397945897058 1 GO:0042054 histone methyltransferase activity 8/2632 67/18639 0.119402985074627 0.845574558816858 0.747397945897058 1 GO:0000175 3'-5'-RNA exonuclease activity 4/2632 35/18639 0.114285714285714 0.809335649153278 0.748172218252527 1 GO:0140566 histone reader activity 4/2632 35/18639 0.114285714285714 0.809335649153278 0.748172218252527 1 GO:0004497 monooxygenase activity 13/2632 106/18639 0.122641509433962 0.868508774445145 0.749390695959792 1 GO:0003725 double-stranded RNA binding 9/2632 75/18639 0.12 0.849802431610942 0.7496674287672 1 GO:0019902 phosphatase binding 24/2632 190/18639 0.126315789473684 0.894528875379939 0.753148948980819 1 GO:0004721 phosphoprotein phosphatase activity 22/2632 175/18639 0.125714285714286 0.890269214068606 0.754018585564459 1 GO:0005385 zinc ion transmembrane transporter activity 3/2632 27/18639 0.111111111111111 0.786854103343465 0.755296752623605 1 GO:0008266 poly(U) RNA binding 3/2632 27/18639 0.111111111111111 0.786854103343465 0.755296752623605 1 GO:0008395 steroid hydroxylase activity 3/2632 27/18639 0.111111111111111 0.786854103343465 0.755296752623605 1 GO:0001098 basal transcription machinery binding 7/2632 60/18639 0.116666666666667 0.826196808510638 0.76150122503058 1 GO:0001099 basal RNA polymerase II transcription machinery binding 7/2632 60/18639 0.116666666666667 0.826196808510638 0.76150122503058 1 GO:0005548 phospholipid transporter activity 8/2632 68/18639 0.117647058823529 0.833139638834257 0.762254747805506 1 GO:0030547 signaling receptor inhibitor activity 5/2632 44/18639 0.113636363636364 0.804737151146726 0.763636982557349 1 GO:0140034 methylation-dependent protein binding 9/2632 76/18639 0.118421052631579 0.838620820668693 0.763690440816057 1 GO:0004527 exonuclease activity 10/2632 84/18639 0.119047619047619 0.843057967867998 0.765591933728764 1 GO:0051117 ATPase binding 10/2632 84/18639 0.119047619047619 0.843057967867998 0.765591933728764 1 GO:0015293 symporter activity 18/2632 146/18639 0.123287671232877 0.873084690011242 0.767567647473345 1 GO:0000993 RNA polymerase II complex binding 4/2632 36/18639 0.111111111111111 0.786854103343465 0.768124359137944 1 GO:0004190 aspartic-type endopeptidase activity 4/2632 36/18639 0.111111111111111 0.786854103343465 0.768124359137944 1 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 45/2632 349/18639 0.128939828080229 0.913111495283964 0.768517599841195 1 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 2/2632 19/18639 0.105263157894737 0.745440729483283 0.771489227496085 1 GO:0004890 GABA-A receptor activity 2/2632 19/18639 0.105263157894737 0.745440729483283 0.771489227496085 1 GO:0015245 fatty acid transmembrane transporter activity 2/2632 19/18639 0.105263157894737 0.745440729483283 0.771489227496085 1 GO:0016918 retinal binding 2/2632 19/18639 0.105263157894737 0.745440729483283 0.771489227496085 1 GO:0030506 ankyrin binding 2/2632 19/18639 0.105263157894737 0.745440729483283 0.771489227496085 1 GO:0046624 sphingolipid transporter activity 2/2632 19/18639 0.105263157894737 0.745440729483283 0.771489227496085 1 GO:0050145 nucleoside monophosphate kinase activity 2/2632 19/18639 0.105263157894737 0.745440729483283 0.771489227496085 1 GO:0070003 threonine-type peptidase activity 2/2632 19/18639 0.105263157894737 0.745440729483283 0.771489227496085 1 GO:0140036 ubiquitin-modified protein reader activity 2/2632 19/18639 0.105263157894737 0.745440729483283 0.771489227496085 1 GO:1990380 K48-linked deubiquitinase activity 2/2632 19/18639 0.105263157894737 0.745440729483283 0.771489227496085 1 GO:0015026 coreceptor activity 7/2632 61/18639 0.114754098360656 0.812652598535054 0.776596210376829 1 GO:0019905 syntaxin binding 7/2632 61/18639 0.114754098360656 0.812652598535054 0.776596210376829 1 GO:0051119 sugar transmembrane transporter activity 3/2632 28/18639 0.107142857142857 0.758752171081198 0.777288180261455 1 GO:0051959 dynein light intermediate chain binding 3/2632 28/18639 0.107142857142857 0.758752171081198 0.777288180261455 1 GO:0005003 ephrin receptor activity 6/2632 53/18639 0.113207547169811 0.801700407180134 0.777877687288812 1 GO:0005005 transmembrane-ephrin receptor activity 6/2632 53/18639 0.113207547169811 0.801700407180134 0.777877687288812 1 GO:0017046 peptide hormone binding 6/2632 53/18639 0.113207547169811 0.801700407180134 0.777877687288812 1 GO:0051018 protein kinase A binding 6/2632 53/18639 0.113207547169811 0.801700407180134 0.777877687288812 1 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 1/2632 10/18639 0.1 0.708168693009119 0.7818772836088 1 GO:0004382 GDP phosphatase activity 1/2632 10/18639 0.1 0.708168693009119 0.7818772836088 1 GO:0004445 inositol-polyphosphate 5-phosphatase activity 1/2632 10/18639 0.1 0.708168693009119 0.7818772836088 1 GO:0004983 neuropeptide Y receptor activity 1/2632 10/18639 0.1 0.708168693009119 0.7818772836088 1 GO:0005131 growth hormone receptor binding 1/2632 10/18639 0.1 0.708168693009119 0.7818772836088 1 GO:0005337 nucleoside transmembrane transporter activity 1/2632 10/18639 0.1 0.708168693009119 0.7818772836088 1 GO:0008519 ammonium channel activity 1/2632 10/18639 0.1 0.708168693009119 0.7818772836088 1 GO:0015658 branched-chain amino acid transmembrane transporter activity 1/2632 10/18639 0.1 0.708168693009119 0.7818772836088 1 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 1/2632 10/18639 0.1 0.708168693009119 0.7818772836088 1 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1/2632 10/18639 0.1 0.708168693009119 0.7818772836088 1 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 1/2632 10/18639 0.1 0.708168693009119 0.7818772836088 1 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 1/2632 10/18639 0.1 0.708168693009119 0.7818772836088 1 GO:0031956 medium-chain fatty acid-CoA ligase activity 1/2632 10/18639 0.1 0.708168693009119 0.7818772836088 1 GO:0032356 oxidized DNA binding 1/2632 10/18639 0.1 0.708168693009119 0.7818772836088 1 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 1/2632 10/18639 0.1 0.708168693009119 0.7818772836088 1 GO:0042166 acetylcholine binding 1/2632 10/18639 0.1 0.708168693009119 0.7818772836088 1 GO:0042975 peroxisome proliferator activated receptor binding 1/2632 10/18639 0.1 0.708168693009119 0.7818772836088 1 GO:0043208 glycosphingolipid binding 1/2632 10/18639 0.1 0.708168693009119 0.7818772836088 1 GO:0045322 unmethylated CpG binding 1/2632 10/18639 0.1 0.708168693009119 0.7818772836088 1 GO:0051864 histone H3K36 demethylase activity 1/2632 10/18639 0.1 0.708168693009119 0.7818772836088 1 GO:0051880 G-quadruplex DNA binding 1/2632 10/18639 0.1 0.708168693009119 0.7818772836088 1 GO:0070739 protein-glutamic acid ligase activity 1/2632 10/18639 0.1 0.708168693009119 0.7818772836088 1 GO:0070740 tubulin-glutamic acid ligase activity 1/2632 10/18639 0.1 0.708168693009119 0.7818772836088 1 GO:0071723 lipopeptide binding 1/2632 10/18639 0.1 0.708168693009119 0.7818772836088 1 GO:0099122 RNA polymerase II C-terminal domain binding 1/2632 10/18639 0.1 0.708168693009119 0.7818772836088 1 GO:0140135 mechanosensitive monoatomic cation channel activity 1/2632 10/18639 0.1 0.708168693009119 0.7818772836088 1 GO:0141109 transporter activator activity 1/2632 10/18639 0.1 0.708168693009119 0.7818772836088 1 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 1/2632 10/18639 0.1 0.708168693009119 0.7818772836088 1 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 1/2632 10/18639 0.1 0.708168693009119 0.7818772836088 1 GO:1905394 retromer complex binding 1/2632 10/18639 0.1 0.708168693009119 0.7818772836088 1 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 1/2632 10/18639 0.1 0.708168693009119 0.7818772836088 1 GO:0008514 organic anion transmembrane transporter activity 34/2632 269/18639 0.12639405204461 0.895083106405577 0.783302268003933 1 GO:0030551 cyclic nucleotide binding 4/2632 37/18639 0.108108108108108 0.765587776226074 0.786815505765001 1 GO:0043394 proteoglycan binding 4/2632 37/18639 0.108108108108108 0.765587776226074 0.786815505765001 1 GO:0070001 aspartic-type peptidase activity 4/2632 37/18639 0.108108108108108 0.765587776226074 0.786815505765001 1 GO:0050660 flavin adenine dinucleotide binding 10/2632 86/18639 0.116279069767442 0.823451968615254 0.790652843739189 1 GO:0019887 protein kinase regulator activity 32/2632 255/18639 0.125490196078431 0.888682281423208 0.790852150161652 1 GO:0015171 amino acid transmembrane transporter activity 12/2632 102/18639 0.117647058823529 0.833139638834257 0.793125600521098 1 GO:0000339 RNA cap binding 2/2632 20/18639 0.1 0.708168693009119 0.795955237072725 1 GO:0001614 purinergic nucleotide receptor activity 2/2632 20/18639 0.1 0.708168693009119 0.795955237072725 1 GO:0001972 retinoic acid binding 2/2632 20/18639 0.1 0.708168693009119 0.795955237072725 1 GO:0005326 neurotransmitter transmembrane transporter activity 2/2632 20/18639 0.1 0.708168693009119 0.795955237072725 1 GO:0016004 phospholipase activator activity 2/2632 20/18639 0.1 0.708168693009119 0.795955237072725 1 GO:0016408 C-acyltransferase activity 2/2632 20/18639 0.1 0.708168693009119 0.795955237072725 1 GO:0016502 nucleotide receptor activity 2/2632 20/18639 0.1 0.708168693009119 0.795955237072725 1 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 2/2632 20/18639 0.1 0.708168693009119 0.795955237072725 1 GO:0061608 nuclear import signal receptor activity 2/2632 20/18639 0.1 0.708168693009119 0.795955237072725 1 GO:0140939 histone H4 methyltransferase activity 2/2632 20/18639 0.1 0.708168693009119 0.795955237072725 1 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 5/2632 46/18639 0.108695652173913 0.769748579357738 0.797223695877218 1 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 3/2632 29/18639 0.103448275862069 0.732588303112881 0.797625771971542 1 GO:0016417 S-acyltransferase activity 3/2632 29/18639 0.103448275862069 0.732588303112881 0.797625771971542 1 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 3/2632 29/18639 0.103448275862069 0.732588303112881 0.797625771971542 1 GO:0097472 cyclin-dependent protein kinase activity 3/2632 29/18639 0.103448275862069 0.732588303112881 0.797625771971542 1 GO:0046982 protein heterodimerization activity 47/2632 369/18639 0.127371273712737 0.902003484320557 0.800018748576356 1 GO:0033293 monocarboxylic acid binding 9/2632 79/18639 0.113924050632911 0.806774460390135 0.80238425653707 1 GO:0005501 retinoid binding 4/2632 38/18639 0.105263157894737 0.745440729483283 0.8042822834046 1 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 4/2632 38/18639 0.105263157894737 0.745440729483283 0.8042822834046 1 GO:0019840 isoprenoid binding 4/2632 38/18639 0.105263157894737 0.745440729483283 0.8042822834046 1 GO:0022824 transmitter-gated monoatomic ion channel activity 7/2632 63/18639 0.111111111111111 0.786854103343465 0.804639799763179 1 GO:0022835 transmitter-gated channel activity 7/2632 63/18639 0.111111111111111 0.786854103343465 0.804639799763179 1 GO:0098632 cell-cell adhesion mediator activity 6/2632 55/18639 0.109090909090909 0.772547665100857 0.807600152736308 1 GO:0019783 ubiquitin-like protein peptidase activity 15/2632 127/18639 0.118110236220472 0.836419716152502 0.80824044793499 1 GO:0015297 antiporter activity 16/2632 135/18639 0.118518518518519 0.839311043566363 0.810001782285357 1 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 1/2632 11/18639 0.0909090909090909 0.643789720917381 0.81269477190885 1 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 1/2632 11/18639 0.0909090909090909 0.643789720917381 0.81269477190885 1 GO:0002162 dystroglycan binding 1/2632 11/18639 0.0909090909090909 0.643789720917381 0.81269477190885 1 GO:0004143 ATP-dependent diacylglycerol kinase activity 1/2632 11/18639 0.0909090909090909 0.643789720917381 0.81269477190885 1 GO:0004523 RNA-DNA hybrid ribonuclease activity 1/2632 11/18639 0.0909090909090909 0.643789720917381 0.81269477190885 1 GO:0008503 benzodiazepine receptor activity 1/2632 11/18639 0.0909090909090909 0.643789720917381 0.81269477190885 1 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 1/2632 11/18639 0.0909090909090909 0.643789720917381 0.81269477190885 1 GO:0016176 superoxide-generating NADPH oxidase activator activity 1/2632 11/18639 0.0909090909090909 0.643789720917381 0.81269477190885 1 GO:0016594 glycine binding 1/2632 11/18639 0.0909090909090909 0.643789720917381 0.81269477190885 1 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 1/2632 11/18639 0.0909090909090909 0.643789720917381 0.81269477190885 1 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 1/2632 11/18639 0.0909090909090909 0.643789720917381 0.81269477190885 1 GO:0019107 myristoyltransferase activity 1/2632 11/18639 0.0909090909090909 0.643789720917381 0.81269477190885 1 GO:0019206 nucleoside kinase activity 1/2632 11/18639 0.0909090909090909 0.643789720917381 0.81269477190885 1 GO:0019864 IgG binding 1/2632 11/18639 0.0909090909090909 0.643789720917381 0.81269477190885 1 GO:0031731 CCR6 chemokine receptor binding 1/2632 11/18639 0.0909090909090909 0.643789720917381 0.81269477190885 1 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 1/2632 11/18639 0.0909090909090909 0.643789720917381 0.81269477190885 1 GO:0032404 mismatch repair complex binding 1/2632 11/18639 0.0909090909090909 0.643789720917381 0.81269477190885 1 GO:0047676 arachidonate-CoA ligase activity 1/2632 11/18639 0.0909090909090909 0.643789720917381 0.81269477190885 1 GO:0050786 RAGE receptor binding 1/2632 11/18639 0.0909090909090909 0.643789720917381 0.81269477190885 1 GO:0070697 activin receptor binding 1/2632 11/18639 0.0909090909090909 0.643789720917381 0.81269477190885 1 GO:0097493 structural molecule activity conferring elasticity 1/2632 11/18639 0.0909090909090909 0.643789720917381 0.81269477190885 1 GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 1/2632 11/18639 0.0909090909090909 0.643789720917381 0.81269477190885 1 GO:0099528 G protein-coupled neurotransmitter receptor activity 1/2632 11/18639 0.0909090909090909 0.643789720917381 0.81269477190885 1 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 1/2632 11/18639 0.0909090909090909 0.643789720917381 0.81269477190885 1 GO:0004197 cysteine-type endopeptidase activity 10/2632 88/18639 0.113636363636364 0.804737151146726 0.81370384313174 1 GO:0032182 ubiquitin-like protein binding 14/2632 120/18639 0.116666666666667 0.826196808510638 0.816231032590221 1 GO:0008187 poly-pyrimidine tract binding 3/2632 30/18639 0.1 0.708168693009119 0.816383979507212 1 GO:0033612 receptor serine/threonine kinase binding 3/2632 30/18639 0.1 0.708168693009119 0.816383979507212 1 GO:0005248 voltage-gated sodium channel activity 2/2632 21/18639 0.0952380952380952 0.674446374294399 0.818071130408673 1 GO:0009931 calcium-dependent protein serine/threonine kinase activity 2/2632 21/18639 0.0952380952380952 0.674446374294399 0.818071130408673 1 GO:0015125 bile acid transmembrane transporter activity 2/2632 21/18639 0.0952380952380952 0.674446374294399 0.818071130408673 1 GO:0015174 basic amino acid transmembrane transporter activity 2/2632 21/18639 0.0952380952380952 0.674446374294399 0.818071130408673 1 GO:0036122 BMP binding 2/2632 21/18639 0.0952380952380952 0.674446374294399 0.818071130408673 1 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 2/2632 21/18639 0.0952380952380952 0.674446374294399 0.818071130408673 1 GO:0051010 microtubule plus-end binding 2/2632 21/18639 0.0952380952380952 0.674446374294399 0.818071130408673 1 GO:0051428 peptide hormone receptor binding 2/2632 21/18639 0.0952380952380952 0.674446374294399 0.818071130408673 1 GO:0017171 serine hydrolase activity 24/2632 198/18639 0.121212121212121 0.858386294556507 0.818975311431391 1 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 6/2632 56/18639 0.107142857142857 0.758752171081198 0.821250445837236 1 GO:0015079 potassium ion transmembrane transporter activity 19/2632 160/18639 0.11875 0.840950322948328 0.823943875951827 1 GO:0015108 chloride transmembrane transporter activity 14/2632 121/18639 0.115702479338843 0.81936873571303 0.825493978707851 1 GO:0031267 small GTPase binding 35/2632 283/18639 0.123674911660777 0.875827005488309 0.825776150341509 1 GO:0038187 pattern recognition receptor activity 5/2632 48/18639 0.104166666666667 0.737675721884498 0.826935298244991 1 GO:0140693 molecular condensate scaffold activity 5/2632 48/18639 0.104166666666667 0.737675721884498 0.826935298244991 1 GO:0016922 nuclear receptor binding 16/2632 137/18639 0.116788321167883 0.82705832760189 0.827620635667692 1 GO:0120013 lipid transfer activity 7/2632 65/18639 0.107692307692308 0.762643207855974 0.829901791809643 1 GO:0005184 neuropeptide hormone activity 3/2632 31/18639 0.0967741935483871 0.685324541621728 0.833642688220739 1 GO:0016411 acylglycerol O-acyltransferase activity 3/2632 31/18639 0.0967741935483871 0.685324541621728 0.833642688220739 1 GO:0008013 beta-catenin binding 12/2632 106/18639 0.113207547169811 0.801700407180134 0.833826938161966 1 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 14/2632 122/18639 0.114754098360656 0.812652598535054 0.83440471922644 1 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 15/2632 130/18639 0.115384615384615 0.817117722702829 0.835086547797085 1 GO:0015036 disulfide oxidoreductase activity 4/2632 40/18639 0.1 0.708168693009119 0.835716043736039 1 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 4/2632 40/18639 0.1 0.708168693009119 0.835716043736039 1 GO:0030021 extracellular matrix structural constituent conferring compression resistance 2/2632 22/18639 0.0909090909090909 0.643789720917381 0.838012496172336 1 GO:0033038 bitter taste receptor activity 2/2632 22/18639 0.0909090909090909 0.643789720917381 0.838012496172336 1 GO:0050321 tau-protein kinase activity 2/2632 22/18639 0.0909090909090909 0.643789720917381 0.838012496172336 1 GO:0000995 RNA polymerase III general transcription initiation factor activity 1/2632 12/18639 0.0833333333333333 0.590140577507599 0.839159629131091 1 GO:0004032 aldose reductase (NADPH) activity 1/2632 12/18639 0.0833333333333333 0.590140577507599 0.839159629131091 1 GO:0004300 enoyl-CoA hydratase activity 1/2632 12/18639 0.0833333333333333 0.590140577507599 0.839159629131091 1 GO:0005025 transforming growth factor beta receptor activity, type I 1/2632 12/18639 0.0833333333333333 0.590140577507599 0.839159629131091 1 GO:0005026 transforming growth factor beta receptor activity, type II 1/2632 12/18639 0.0833333333333333 0.590140577507599 0.839159629131091 1 GO:0005078 MAP-kinase scaffold activity 1/2632 12/18639 0.0833333333333333 0.590140577507599 0.839159629131091 1 GO:0005165 neurotrophin receptor binding 1/2632 12/18639 0.0833333333333333 0.590140577507599 0.839159629131091 1 GO:0005247 voltage-gated chloride channel activity 1/2632 12/18639 0.0833333333333333 0.590140577507599 0.839159629131091 1 GO:0005436 sodium:phosphate symporter activity 1/2632 12/18639 0.0833333333333333 0.590140577507599 0.839159629131091 1 GO:0010853 cyclase activator activity 1/2632 12/18639 0.0833333333333333 0.590140577507599 0.839159629131091 1 GO:0015368 calcium:monoatomic cation antiporter activity 1/2632 12/18639 0.0833333333333333 0.590140577507599 0.839159629131091 1 GO:0016361 activin receptor activity, type I 1/2632 12/18639 0.0833333333333333 0.590140577507599 0.839159629131091 1 GO:0016362 activin receptor activity, type II 1/2632 12/18639 0.0833333333333333 0.590140577507599 0.839159629131091 1 GO:0016801 hydrolase activity, acting on ether bonds 1/2632 12/18639 0.0833333333333333 0.590140577507599 0.839159629131091 1 GO:0016803 ether hydrolase activity 1/2632 12/18639 0.0833333333333333 0.590140577507599 0.839159629131091 1 GO:0017002 activin receptor activity 1/2632 12/18639 0.0833333333333333 0.590140577507599 0.839159629131091 1 GO:0034452 dynactin binding 1/2632 12/18639 0.0833333333333333 0.590140577507599 0.839159629131091 1 GO:0035251 UDP-glucosyltransferase activity 1/2632 12/18639 0.0833333333333333 0.590140577507599 0.839159629131091 1 GO:0035497 cAMP response element binding 1/2632 12/18639 0.0833333333333333 0.590140577507599 0.839159629131091 1 GO:0042301 phosphate ion binding 1/2632 12/18639 0.0833333333333333 0.590140577507599 0.839159629131091 1 GO:0045295 gamma-catenin binding 1/2632 12/18639 0.0833333333333333 0.590140577507599 0.839159629131091 1 GO:0070410 co-SMAD binding 1/2632 12/18639 0.0833333333333333 0.590140577507599 0.839159629131091 1 GO:0097677 STAT family protein binding 1/2632 12/18639 0.0833333333333333 0.590140577507599 0.839159629131091 1 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 1/2632 12/18639 0.0833333333333333 0.590140577507599 0.839159629131091 1 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 1/2632 12/18639 0.0833333333333333 0.590140577507599 0.839159629131091 1 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 1/2632 12/18639 0.0833333333333333 0.590140577507599 0.839159629131091 1 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 1/2632 12/18639 0.0833333333333333 0.590140577507599 0.839159629131091 1 GO:0141221 histone deacetylase activity, hydrolytic mechanism 1/2632 12/18639 0.0833333333333333 0.590140577507599 0.839159629131091 1 GO:1990459 transferrin receptor binding 1/2632 12/18639 0.0833333333333333 0.590140577507599 0.839159629131091 1 GO:0008236 serine-type peptidase activity 23/2632 194/18639 0.118556701030928 0.83958144016545 0.845197044280276 1 GO:0061980 regulatory RNA binding 6/2632 58/18639 0.103448275862069 0.732588303112881 0.846235240853341 1 GO:0015291 secondary active transmembrane transporter activity 35/2632 287/18639 0.121951219512195 0.863620357328193 0.848834898782274 1 GO:0019207 kinase regulator activity 35/2632 287/18639 0.121951219512195 0.863620357328193 0.848834898782274 1 GO:0160041 neuropeptide activity 3/2632 32/18639 0.09375 0.663908149696049 0.849485121772745 1 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 4/2632 41/18639 0.0975609756097561 0.690896285862555 0.84977936146441 1 GO:0008227 G protein-coupled amine receptor activity 4/2632 41/18639 0.0975609756097561 0.690896285862555 0.84977936146441 1 GO:0043130 ubiquitin binding 11/2632 100/18639 0.11 0.77898556231003 0.852610391088522 1 GO:0032813 tumor necrosis factor receptor superfamily binding 5/2632 50/18639 0.1 0.708168693009119 0.853010401402713 1 GO:0031681 G-protein beta-subunit binding 2/2632 23/18639 0.0869565217391304 0.61579886348619 0.855952212095573 1 GO:0043274 phospholipase binding 2/2632 23/18639 0.0869565217391304 0.61579886348619 0.855952212095573 1 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 2/2632 23/18639 0.0869565217391304 0.61579886348619 0.855952212095573 1 GO:0005216 monoatomic ion channel activity 56/2632 448/18639 0.125 0.885210866261398 0.857369403360825 1 GO:0070063 RNA polymerase binding 6/2632 59/18639 0.101694915254237 0.720171552212663 0.857618802895459 1 GO:0005244 voltage-gated monoatomic ion channel activity 20/2632 173/18639 0.115606936416185 0.81869213064638 0.861493266196359 1 GO:0002161 aminoacyl-tRNA editing activity 1/2632 13/18639 0.0769230769230769 0.544745148468553 0.861886415845375 1 GO:0005338 nucleotide-sugar transmembrane transporter activity 1/2632 13/18639 0.0769230769230769 0.544745148468553 0.861886415845375 1 GO:0008417 fucosyltransferase activity 1/2632 13/18639 0.0769230769230769 0.544745148468553 0.861886415845375 1 GO:0019855 calcium channel inhibitor activity 1/2632 13/18639 0.0769230769230769 0.544745148468553 0.861886415845375 1 GO:0031432 titin binding 1/2632 13/18639 0.0769230769230769 0.544745148468553 0.861886415845375 1 GO:0046975 histone H3K36 methyltransferase activity 1/2632 13/18639 0.0769230769230769 0.544745148468553 0.861886415845375 1 GO:0051011 microtubule minus-end binding 1/2632 13/18639 0.0769230769230769 0.544745148468553 0.861886415845375 1 GO:0061459 L-arginine transmembrane transporter activity 1/2632 13/18639 0.0769230769230769 0.544745148468553 0.861886415845375 1 GO:0070123 transforming growth factor beta receptor activity, type III 1/2632 13/18639 0.0769230769230769 0.544745148468553 0.861886415845375 1 GO:0071714 icosanoid transmembrane transporter activity 1/2632 13/18639 0.0769230769230769 0.544745148468553 0.861886415845375 1 GO:0089720 caspase binding 1/2632 13/18639 0.0769230769230769 0.544745148468553 0.861886415845375 1 GO:0140333 glycerophospholipid flippase activity 1/2632 13/18639 0.0769230769230769 0.544745148468553 0.861886415845375 1 GO:0140410 monoatomic cation:bicarbonate symporter activity 1/2632 13/18639 0.0769230769230769 0.544745148468553 0.861886415845375 1 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 1/2632 13/18639 0.0769230769230769 0.544745148468553 0.861886415845375 1 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 21/2632 181/18639 0.116022099447514 0.821632185259198 0.862363934211596 1 GO:0043175 RNA polymerase core enzyme binding 4/2632 42/18639 0.0952380952380952 0.674446374294399 0.86280883060513 1 GO:0140311 protein sequestering activity 3/2632 33/18639 0.0909090909090909 0.643789720917381 0.863996099550655 1 GO:0005048 signal sequence binding 5/2632 51/18639 0.0980392156862745 0.694283032361881 0.864770305687691 1 GO:0005272 sodium channel activity 5/2632 51/18639 0.0980392156862745 0.694283032361881 0.864770305687691 1 GO:0016597 amino acid binding 5/2632 51/18639 0.0980392156862745 0.694283032361881 0.864770305687691 1 GO:0016830 carbon-carbon lyase activity 5/2632 51/18639 0.0980392156862745 0.694283032361881 0.864770305687691 1 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 6/2632 60/18639 0.1 0.708168693009119 0.868298533769335 1 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 6/2632 60/18639 0.1 0.708168693009119 0.868298533769335 1 GO:0008017 microtubule binding 33/2632 276/18639 0.119565217391304 0.846723437293511 0.871600719527537 1 GO:0004806 triacylglycerol lipase activity 2/2632 24/18639 0.0833333333333333 0.590140577507599 0.872057709984056 1 GO:0005540 hyaluronic acid binding 2/2632 24/18639 0.0833333333333333 0.590140577507599 0.872057709984056 1 GO:0015149 hexose transmembrane transporter activity 2/2632 24/18639 0.0833333333333333 0.590140577507599 0.872057709984056 1 GO:0030215 semaphorin receptor binding 2/2632 24/18639 0.0833333333333333 0.590140577507599 0.872057709984056 1 GO:0055056 D-glucose transmembrane transporter activity 2/2632 24/18639 0.0833333333333333 0.590140577507599 0.872057709984056 1 GO:0060229 lipase activator activity 2/2632 24/18639 0.0833333333333333 0.590140577507599 0.872057709984056 1 GO:0022843 voltage-gated monoatomic cation channel activity 16/2632 143/18639 0.111888111888112 0.792356579590622 0.873180130345775 1 GO:0042826 histone deacetylase binding 14/2632 127/18639 0.110236220472441 0.780658401742335 0.873866356152085 1 GO:0022832 voltage-gated channel activity 20/2632 175/18639 0.114285714285714 0.809335649153278 0.874112563971271 1 GO:0004712 protein serine/threonine/tyrosine kinase activity 4/2632 43/18639 0.0930232558139535 0.658761574892203 0.874857698279875 1 GO:0005245 voltage-gated calcium channel activity 4/2632 43/18639 0.0930232558139535 0.658761574892203 0.874857698279875 1 GO:0015035 protein-disulfide reductase activity 3/2632 34/18639 0.0882352941176471 0.624854729125693 0.877260607417703 1 GO:0051427 hormone receptor binding 3/2632 34/18639 0.0882352941176471 0.624854729125693 0.877260607417703 1 GO:0001216 DNA-binding transcription activator activity 61/2632 491/18639 0.124236252545825 0.879802245897276 0.878200495318835 1 GO:0004252 serine-type endopeptidase activity 20/2632 176/18639 0.113636363636364 0.804737151146726 0.88007732293526 1 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 60/2632 484/18639 0.12396694214876 0.877895073978246 0.880225514943064 1 GO:0005344 oxygen carrier activity 1/2632 14/18639 0.0714285714285714 0.505834780720799 0.881402949373506 1 GO:0008392 arachidonate epoxygenase activity 1/2632 14/18639 0.0714285714285714 0.505834780720799 0.881402949373506 1 GO:0008494 translation activator activity 1/2632 14/18639 0.0714285714285714 0.505834780720799 0.881402949373506 1 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 1/2632 14/18639 0.0714285714285714 0.505834780720799 0.881402949373506 1 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 1/2632 14/18639 0.0714285714285714 0.505834780720799 0.881402949373506 1 GO:0061665 SUMO ligase activity 1/2632 14/18639 0.0714285714285714 0.505834780720799 0.881402949373506 1 GO:0098821 BMP receptor activity 1/2632 14/18639 0.0714285714285714 0.505834780720799 0.881402949373506 1 GO:1990825 sequence-specific mRNA binding 1/2632 14/18639 0.0714285714285714 0.505834780720799 0.881402949373506 1 GO:0008146 sulfotransferase activity 5/2632 53/18639 0.0943396226415094 0.668083672650112 0.885920305146951 1 GO:0016251 RNA polymerase II general transcription initiation factor activity 5/2632 53/18639 0.0943396226415094 0.668083672650112 0.885920305146951 1 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 5/2632 53/18639 0.0943396226415094 0.668083672650112 0.885920305146951 1 GO:0001848 complement binding 2/2632 25/18639 0.08 0.566534954407295 0.886489066673816 1 GO:0005251 delayed rectifier potassium channel activity 2/2632 25/18639 0.08 0.566534954407295 0.886489066673816 1 GO:0008483 transaminase activity 2/2632 25/18639 0.08 0.566534954407295 0.886489066673816 1 GO:0015662 P-type ion transporter activity 2/2632 25/18639 0.08 0.566534954407295 0.886489066673816 1 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 2/2632 25/18639 0.08 0.566534954407295 0.886489066673816 1 GO:0019706 protein-cysteine S-palmitoyltransferase activity 2/2632 25/18639 0.08 0.566534954407295 0.886489066673816 1 GO:0019707 protein-cysteine S-acyltransferase activity 2/2632 25/18639 0.08 0.566534954407295 0.886489066673816 1 GO:0042974 nuclear retinoic acid receptor binding 2/2632 25/18639 0.08 0.566534954407295 0.886489066673816 1 GO:0120020 cholesterol transfer activity 2/2632 25/18639 0.08 0.566534954407295 0.886489066673816 1 GO:0140358 P-type transmembrane transporter activity 2/2632 25/18639 0.08 0.566534954407295 0.886489066673816 1 GO:0016407 acetyltransferase activity 10/2632 96/18639 0.104166666666667 0.737675721884498 0.887057208117052 1 GO:0004674 protein serine/threonine kinase activity 53/2632 433/18639 0.122401847575058 0.8668115641913 0.887848631339158 1 GO:0034061 DNA polymerase activity 3/2632 35/18639 0.0857142857142857 0.607001736864959 0.889362643901938 1 GO:0043015 gamma-tubulin binding 3/2632 35/18639 0.0857142857142857 0.607001736864959 0.889362643901938 1 GO:0042277 peptide binding 29/2632 249/18639 0.116465863453815 0.824774783022668 0.89114726095769 1 GO:0005319 lipid transporter activity 20/2632 178/18639 0.112359550561798 0.795695160684403 0.891339080651264 1 GO:0030594 neurotransmitter receptor activity 10/2632 97/18639 0.103092783505155 0.730070817535174 0.894287826218212 1 GO:0008234 cysteine-type peptidase activity 21/2632 187/18639 0.112299465240642 0.795269655250882 0.896699244373386 1 GO:0003727 single-stranded RNA binding 9/2632 89/18639 0.101123595505618 0.716125644615963 0.897355542251053 1 GO:0004559 alpha-mannosidase activity 1/2632 15/18639 0.0666666666666667 0.472112462006079 0.898162543319758 1 GO:0015250 water channel activity 1/2632 15/18639 0.0666666666666667 0.472112462006079 0.898162543319758 1 GO:0015929 hexosaminidase activity 1/2632 15/18639 0.0666666666666667 0.472112462006079 0.898162543319758 1 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 1/2632 15/18639 0.0666666666666667 0.472112462006079 0.898162543319758 1 GO:0042809 nuclear vitamin D receptor binding 1/2632 15/18639 0.0666666666666667 0.472112462006079 0.898162543319758 1 GO:0045504 dynein heavy chain binding 1/2632 15/18639 0.0666666666666667 0.472112462006079 0.898162543319758 1 GO:0120283 protein serine/threonine kinase binding 1/2632 15/18639 0.0666666666666667 0.472112462006079 0.898162543319758 1 GO:0141050 histone H3K deacetylase activity 1/2632 15/18639 0.0666666666666667 0.472112462006079 0.898162543319758 1 GO:0141051 histone H4K deacetylase activity 1/2632 15/18639 0.0666666666666667 0.472112462006079 0.898162543319758 1 GO:0000149 SNARE binding 11/2632 106/18639 0.10377358490566 0.734892039915123 0.898581680489958 1 GO:0140767 enzyme-substrate adaptor activity 15/2632 139/18639 0.107913669064748 0.764210819794013 0.898680025042253 1 GO:0004529 DNA exonuclease activity 2/2632 26/18639 0.0769230769230769 0.544745148468553 0.899397742341836 1 GO:0005227 calcium-activated cation channel activity 2/2632 26/18639 0.0769230769230769 0.544745148468553 0.899397742341836 1 GO:0015145 monosaccharide transmembrane transporter activity 2/2632 26/18639 0.0769230769230769 0.544745148468553 0.899397742341836 1 GO:0019865 immunoglobulin binding 2/2632 26/18639 0.0769230769230769 0.544745148468553 0.899397742341836 1 GO:0070006 metalloaminopeptidase activity 2/2632 26/18639 0.0769230769230769 0.544745148468553 0.899397742341836 1 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 3/2632 36/18639 0.0833333333333333 0.590140577507599 0.90038430615321 1 GO:0016409 palmitoyltransferase activity 3/2632 36/18639 0.0833333333333333 0.590140577507599 0.90038430615321 1 GO:0044390 ubiquitin-like protein conjugating enzyme binding 3/2632 36/18639 0.0833333333333333 0.590140577507599 0.90038430615321 1 GO:0101005 deubiquitinase activity 12/2632 115/18639 0.104347826086957 0.738958636183428 0.902810535352067 1 GO:0005179 hormone activity 14/2632 132/18639 0.106060606060606 0.751088007736944 0.905475199125846 1 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 4/2632 46/18639 0.0869565217391304 0.61579886348619 0.90565782851575 1 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 7/2632 73/18639 0.0958904109589041 0.679065870008744 0.90605576255468 1 GO:0004677 DNA-dependent protein kinase activity 28/2632 246/18639 0.113821138211382 0.806045666839647 0.912033203818761 1 GO:0170055 lipid transmembrane transporter activity 5/2632 56/18639 0.0892857142857143 0.632293475900999 0.91229437660628 1 GO:0000062 fatty-acyl-CoA binding 1/2632 16/18639 0.0625 0.442605433130699 0.912554520659878 1 GO:0003688 DNA replication origin binding 1/2632 16/18639 0.0625 0.442605433130699 0.912554520659878 1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 1/2632 16/18639 0.0625 0.442605433130699 0.912554520659878 1 GO:0005024 transforming growth factor beta receptor activity 1/2632 16/18639 0.0625 0.442605433130699 0.912554520659878 1 GO:0008391 arachidonate monooxygenase activity 1/2632 16/18639 0.0625 0.442605433130699 0.912554520659878 1 GO:0015385 sodium:proton antiporter activity 1/2632 16/18639 0.0625 0.442605433130699 0.912554520659878 1 GO:0015923 mannosidase activity 1/2632 16/18639 0.0625 0.442605433130699 0.912554520659878 1 GO:0031435 mitogen-activated protein kinase kinase kinase binding 1/2632 16/18639 0.0625 0.442605433130699 0.912554520659878 1 GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 1/2632 16/18639 0.0625 0.442605433130699 0.912554520659878 1 GO:0140327 flippase activity 1/2632 16/18639 0.0625 0.442605433130699 0.912554520659878 1 GO:0140328 floppase activity 1/2632 16/18639 0.0625 0.442605433130699 0.912554520659878 1 GO:0003678 DNA helicase activity 7/2632 74/18639 0.0945945945945946 0.669889304197815 0.913135378943322 1 GO:0043495 protein-membrane adaptor activity 4/2632 47/18639 0.0851063829787234 0.602696760007761 0.914319007216782 1 GO:0005254 chloride channel activity 8/2632 83/18639 0.0963855421686747 0.682572234225656 0.914852834549987 1 GO:0005261 monoatomic cation channel activity 40/2632 341/18639 0.117302052785924 0.830696414086943 0.915481634838361 1 GO:0042393 histone binding 28/2632 247/18639 0.11336032388664 0.80278232405892 0.915927068272003 1 GO:0005096 GTPase activator activity 31/2632 271/18639 0.114391143911439 0.810082268755818 0.917013244873624 1 GO:0004679 AMP-activated protein kinase activity 28/2632 248/18639 0.112903225806452 0.799545298558682 0.91967984961987 1 GO:0008527 taste receptor activity 2/2632 28/18639 0.0714285714285714 0.505834780720799 0.921205640077589 1 GO:0045499 chemorepellent activity 2/2632 28/18639 0.0714285714285714 0.505834780720799 0.921205640077589 1 GO:0004222 metalloendopeptidase activity 11/2632 110/18639 0.1 0.708168693009119 0.922090291043822 1 GO:0008188 neuropeptide receptor activity 4/2632 48/18639 0.0833333333333333 0.590140577507599 0.922262980759673 1 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 4/2632 48/18639 0.0833333333333333 0.590140577507599 0.922262980759673 1 GO:0060589 nucleoside-triphosphatase regulator activity 59/2632 490/18639 0.120408163265306 0.852692916072204 0.92246272350458 1 GO:0008238 exopeptidase activity 10/2632 102/18639 0.0980392156862745 0.694283032361881 0.924908546549098 1 GO:0008569 minus-end-directed microtubule motor activity 1/2632 17/18639 0.0588235294117647 0.416569819417129 0.924913243831397 1 GO:0015278 intracellularly gated calcium channel activity 1/2632 17/18639 0.0588235294117647 0.416569819417129 0.924913243831397 1 GO:0016018 cyclosporin A binding 1/2632 17/18639 0.0588235294117647 0.416569819417129 0.924913243831397 1 GO:0030548 acetylcholine receptor regulator activity 1/2632 17/18639 0.0588235294117647 0.416569819417129 0.924913243831397 1 GO:0045125 bioactive lipid receptor activity 1/2632 17/18639 0.0588235294117647 0.416569819417129 0.924913243831397 1 GO:0070403 NAD+ binding 1/2632 17/18639 0.0588235294117647 0.416569819417129 0.924913243831397 1 GO:1901567 fatty acid derivative binding 1/2632 17/18639 0.0588235294117647 0.416569819417129 0.924913243831397 1 GO:0140789 histone phosphatase activity 14/2632 136/18639 0.102941176470588 0.728997183979975 0.925788284255925 1 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 27/2632 243/18639 0.111111111111111 0.786854103343465 0.930095852141922 1 GO:0004879 nuclear receptor activity 5/2632 59/18639 0.0847457627118644 0.600142960177219 0.93315340496497 1 GO:0000900 mRNA regulatory element binding translation repressor activity 1/2632 18/18639 0.0555555555555556 0.393427051671733 0.93552587095178 1 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 1/2632 18/18639 0.0555555555555556 0.393427051671733 0.93552587095178 1 GO:0005372 water transmembrane transporter activity 1/2632 18/18639 0.0555555555555556 0.393427051671733 0.93552587095178 1 GO:0008409 5'-3' exonuclease activity 1/2632 18/18639 0.0555555555555556 0.393427051671733 0.93552587095178 1 GO:0015280 ligand-gated sodium channel activity 1/2632 18/18639 0.0555555555555556 0.393427051671733 0.93552587095178 1 GO:0017128 phospholipid scramblase activity 1/2632 18/18639 0.0555555555555556 0.393427051671733 0.93552587095178 1 GO:0032393 MHC class I receptor activity 1/2632 18/18639 0.0555555555555556 0.393427051671733 0.93552587095178 1 GO:0050811 GABA receptor binding 1/2632 18/18639 0.0555555555555556 0.393427051671733 0.93552587095178 1 GO:0099602 neurotransmitter receptor regulator activity 1/2632 18/18639 0.0555555555555556 0.393427051671733 0.93552587095178 1 GO:0004676 3-phosphoinositide-dependent protein kinase activity 27/2632 245/18639 0.110204081632653 0.780430804540661 0.936508878969086 1 GO:0004711 ribosomal protein S6 kinase activity 27/2632 245/18639 0.110204081632653 0.780430804540661 0.936508878969086 1 GO:0035175 histone H3S10 kinase activity 27/2632 245/18639 0.110204081632653 0.780430804540661 0.936508878969086 1 GO:0035979 histone H2AXS139 kinase activity 27/2632 245/18639 0.110204081632653 0.780430804540661 0.936508878969086 1 GO:0044022 histone H3S28 kinase activity 27/2632 245/18639 0.110204081632653 0.780430804540661 0.936508878969086 1 GO:0044023 histone H4S1 kinase activity 27/2632 245/18639 0.110204081632653 0.780430804540661 0.936508878969086 1 GO:0044024 histone H2AS1 kinase activity 27/2632 245/18639 0.110204081632653 0.780430804540661 0.936508878969086 1 GO:0044025 histone H2BS14 kinase activity 27/2632 245/18639 0.110204081632653 0.780430804540661 0.936508878969086 1 GO:0072354 histone H3T3 kinase activity 27/2632 245/18639 0.110204081632653 0.780430804540661 0.936508878969086 1 GO:0072371 histone H2AS121 kinase activity 27/2632 245/18639 0.110204081632653 0.780430804540661 0.936508878969086 1 GO:0072518 Rho-dependent protein serine/threonine kinase activity 27/2632 245/18639 0.110204081632653 0.780430804540661 0.936508878969086 1 GO:0140823 histone H2BS36 kinase activity 27/2632 245/18639 0.110204081632653 0.780430804540661 0.936508878969086 1 GO:0140855 histone H3S57 kinase activity 27/2632 245/18639 0.110204081632653 0.780430804540661 0.936508878969086 1 GO:0140995 histone H2A kinase activity 27/2632 245/18639 0.110204081632653 0.780430804540661 0.936508878969086 1 GO:0140997 histone H4 kinase activity 27/2632 245/18639 0.110204081632653 0.780430804540661 0.936508878969086 1 GO:0140998 histone H2B kinase activity 27/2632 245/18639 0.110204081632653 0.780430804540661 0.936508878969086 1 GO:1990244 histone H2AT120 kinase activity 27/2632 245/18639 0.110204081632653 0.780430804540661 0.936508878969086 1 GO:0008080 N-acetyltransferase activity 6/2632 69/18639 0.0869565217391304 0.61579886348619 0.937487338968274 1 GO:0098960 postsynaptic neurotransmitter receptor activity 6/2632 69/18639 0.0869565217391304 0.61579886348619 0.937487338968274 1 GO:0030695 GTPase regulator activity 58/2632 489/18639 0.118609406952965 0.839954687004681 0.938441077167636 1 GO:0030295 protein kinase activator activity 14/2632 139/18639 0.100719424460432 0.713263431807745 0.938488142180277 1 GO:0022839 monoatomic ion-gated channel activity 2/2632 30/18639 0.0666666666666667 0.472112462006079 0.938500827587064 1 GO:0032452 histone demethylase activity 2/2632 30/18639 0.0666666666666667 0.472112462006079 0.938500827587064 1 GO:0070566 adenylyltransferase activity 2/2632 30/18639 0.0666666666666667 0.472112462006079 0.938500827587064 1 GO:0098531 ligand-modulated transcription factor activity 5/2632 60/18639 0.0833333333333333 0.590140577507599 0.939049302346391 1 GO:0140857 histone H3T45 kinase activity 27/2632 246/18639 0.109756097560976 0.777258321595374 0.939526427960222 1 GO:0004812 aminoacyl-tRNA ligase activity 3/2632 41/18639 0.0731707317073171 0.518172214396916 0.941952076214926 1 GO:0016875 ligase activity, forming carbon-oxygen bonds 3/2632 41/18639 0.0731707317073171 0.518172214396916 0.941952076214926 1 GO:0042287 MHC protein binding 3/2632 41/18639 0.0731707317073171 0.518172214396916 0.941952076214926 1 GO:0035402 histone H3T11 kinase activity 27/2632 247/18639 0.109311740890688 0.774111526771101 0.942422713012867 1 GO:0035403 histone H3T6 kinase activity 27/2632 247/18639 0.109311740890688 0.774111526771101 0.942422713012867 1 GO:0005516 calmodulin binding 22/2632 207/18639 0.106280193236715 0.75264305537201 0.944148271869293 1 GO:0008301 DNA binding, bending 1/2632 19/18639 0.0526315789473684 0.372720364741641 0.944639017810429 1 GO:0008381 mechanosensitive monoatomic ion channel activity 1/2632 19/18639 0.0526315789473684 0.372720364741641 0.944639017810429 1 GO:0008574 plus-end-directed microtubule motor activity 1/2632 19/18639 0.0526315789473684 0.372720364741641 0.944639017810429 1 GO:0042834 peptidoglycan binding 1/2632 19/18639 0.0526315789473684 0.372720364741641 0.944639017810429 1 GO:0005164 tumor necrosis factor receptor binding 2/2632 31/18639 0.0645161290322581 0.456883027747818 0.945732423405432 1 GO:0140457 protein demethylase activity 2/2632 31/18639 0.0645161290322581 0.456883027747818 0.945732423405432 1 GO:0019894 kinesin binding 3/2632 42/18639 0.0714285714285714 0.505834780720799 0.94804001818491 1 GO:0048487 beta-tubulin binding 3/2632 42/18639 0.0714285714285714 0.505834780720799 0.94804001818491 1 GO:0015631 tubulin binding 44/2632 385/18639 0.114285714285714 0.809335649153278 0.949200414759064 1 GO:0008237 metallopeptidase activity 19/2632 184/18639 0.103260869565217 0.731261150389851 0.949261219449403 1 GO:0120015 sterol transfer activity 2/2632 32/18639 0.0625 0.442605433130699 0.952148910180944 1 GO:0042288 MHC class I protein binding 1/2632 20/18639 0.05 0.354084346504559 0.952464479954519 1 GO:0034212 protein N-acetyltransferase activity 4/2632 53/18639 0.0754716981132075 0.534466938120089 0.952870113272865 1 GO:0008375 acetylglucosaminyltransferase activity 3/2632 43/18639 0.0697674418604651 0.494071181169152 0.953528692177788 1 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 8/2632 91/18639 0.0879120879120879 0.62256588396406 0.954445340657394 1 GO:0003774 cytoskeletal motor activity 15/2632 153/18639 0.0980392156862745 0.694283032361881 0.956817664532005 1 GO:0004175 endopeptidase activity 46/2632 405/18639 0.11358024691358 0.804339750084431 0.957355629351215 1 GO:0140463 chromatin-protein adaptor activity 4/2632 54/18639 0.0740740740740741 0.524569402228977 0.957468779099071 1 GO:0019239 deaminase activity 2/2632 33/18639 0.0606060606060606 0.429193147278254 0.957836188286124 1 GO:0019956 chemokine binding 2/2632 33/18639 0.0606060606060606 0.429193147278254 0.957836188286124 1 GO:0030296 protein tyrosine kinase activator activity 2/2632 33/18639 0.0606060606060606 0.429193147278254 0.957836188286124 1 GO:0042923 neuropeptide binding 2/2632 33/18639 0.0606060606060606 0.429193147278254 0.957836188286124 1 GO:0001046 core promoter sequence-specific DNA binding 3/2632 44/18639 0.0681818181818182 0.482842290688035 0.958471296250397 1 GO:0001846 opsonin binding 1/2632 21/18639 0.0476190476190476 0.337223187147199 0.959184147431811 1 GO:0031490 chromatin DNA binding 12/2632 128/18639 0.09375 0.663908149696049 0.959293382332977 1 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 12/2632 128/18639 0.09375 0.663908149696049 0.959293382332977 1 GO:0031491 nucleosome binding 6/2632 74/18639 0.0810810810810811 0.574190832169556 0.959900937763411 1 GO:0015020 glucuronosyltransferase activity 2/2632 34/18639 0.0588235294117647 0.416569819417129 0.9628721620904 1 GO:0016831 carboxy-lyase activity 2/2632 34/18639 0.0588235294117647 0.416569819417129 0.9628721620904 1 GO:0019825 oxygen binding 2/2632 34/18639 0.0588235294117647 0.416569819417129 0.9628721620904 1 GO:0046915 transition metal ion transmembrane transporter activity 3/2632 45/18639 0.0666666666666667 0.472112462006079 0.962917190732303 1 GO:0106310 protein serine kinase activity 40/2632 361/18639 0.110803324099723 0.784674452087666 0.963510107997703 1 GO:0004722 protein serine/threonine phosphatase activity 9/2632 103/18639 0.087378640776699 0.618788178357482 0.964038653900872 1 GO:0005243 gap junction channel activity 1/2632 22/18639 0.0454545454545455 0.32189486045869 0.964954226063215 1 GO:0140784 metal ion sensor activity 1/2632 22/18639 0.0454545454545455 0.32189486045869 0.964954226063215 1 GO:0030170 pyridoxal phosphate binding 4/2632 56/18639 0.0714285714285714 0.505834780720799 0.965445974756045 1 GO:0019209 kinase activator activity 14/2632 148/18639 0.0945945945945946 0.669889304197815 0.966017648474537 1 GO:0008528 G protein-coupled peptide receptor activity 11/2632 122/18639 0.0901639344262295 0.638512755991828 0.966838001582091 1 GO:0004180 carboxypeptidase activity 3/2632 46/18639 0.0652173913043478 0.461849147614642 0.966912029956714 1 GO:0005154 epidermal growth factor receptor binding 2/2632 35/18639 0.0571428571428571 0.404667824576639 0.967327284404853 1 GO:0070279 vitamin B6 binding 4/2632 57/18639 0.0701754385964912 0.496960486322188 0.968890119784031 1 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 1/2632 23/18639 0.0434782608695652 0.307899431743095 0.969908863061744 1 GO:0070577 lysine-acetylated histone binding 1/2632 23/18639 0.0434782608695652 0.307899431743095 0.969908863061744 1 GO:0004869 cysteine-type endopeptidase inhibitor activity 2/2632 36/18639 0.0555555555555556 0.393427051671733 0.971265106654949 1 GO:0140223 general transcription initiation factor activity 5/2632 68/18639 0.0735294117647059 0.520712274271411 0.971721101429954 1 GO:0140033 acetylation-dependent protein binding 1/2632 24/18639 0.0416666666666667 0.295070288753799 0.974163261021644 1 GO:0015370 solute:sodium symporter activity 6/2632 79/18639 0.0759493670886076 0.53784964026009 0.974750993046598 1 GO:0036002 pre-mRNA binding 4/2632 59/18639 0.0677966101694915 0.480114368141775 0.974837489191306 1 GO:0004843 cysteine-type deubiquitinase activity 9/2632 108/18639 0.0833333333333333 0.590140577507599 0.976048423865241 1 GO:0000146 microfilament motor activity 2/2632 38/18639 0.0526315789473684 0.372720364741641 0.977811794518462 1 GO:0005537 D-mannose binding 1/2632 25/18639 0.04 0.283267477203647 0.977816352452803 1 GO:0008139 nuclear localization sequence binding 1/2632 25/18639 0.04 0.283267477203647 0.977816352452803 1 GO:0017056 structural constituent of nuclear pore 1/2632 25/18639 0.04 0.283267477203647 0.977816352452803 1 GO:0001653 peptide receptor activity 11/2632 128/18639 0.0859375 0.608582470554711 0.979049568575309 1 GO:0048020 CCR chemokine receptor binding 3/2632 50/18639 0.06 0.424901215805471 0.979173346384503 1 GO:0001637 G protein-coupled chemoattractant receptor activity 1/2632 26/18639 0.0384615384615385 0.272372574234276 0.980953096857242 1 GO:0004950 chemokine receptor activity 1/2632 26/18639 0.0384615384615385 0.272372574234276 0.980953096857242 1 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 1/2632 26/18639 0.0384615384615385 0.272372574234276 0.980953096857242 1 GO:0030507 spectrin binding 1/2632 26/18639 0.0384615384615385 0.272372574234276 0.980953096857242 1 GO:0051139 metal cation:proton antiporter activity 1/2632 26/18639 0.0384615384615385 0.272372574234276 0.980953096857242 1 GO:0052742 phosphatidylinositol kinase activity 1/2632 26/18639 0.0384615384615385 0.272372574234276 0.980953096857242 1 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 6/2632 83/18639 0.072289156626506 0.511929175669242 0.982769791924341 1 GO:0004713 protein tyrosine kinase activity 12/2632 140/18639 0.0857142857142857 0.607001736864959 0.983292239482922 1 GO:0005104 fibroblast growth factor receptor binding 1/2632 27/18639 0.037037037037037 0.262284701114488 0.983646453601009 1 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 1/2632 27/18639 0.037037037037037 0.262284701114488 0.983646453601009 1 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 22/2632 229/18639 0.0960698689956332 0.680336735641948 0.98452416230349 1 GO:0001727 lipid kinase activity 2/2632 41/18639 0.0487804878048781 0.345448142931277 0.985002853689362 1 GO:0140828 metal cation:monoatomic cation antiporter activity 2/2632 41/18639 0.0487804878048781 0.345448142931277 0.985002853689362 1 GO:0005246 calcium channel regulator activity 3/2632 53/18639 0.0566037735849057 0.400850203590067 0.985380878980688 1 GO:0005242 inward rectifier potassium channel activity 1/2632 28/18639 0.0357142857142857 0.2529173903604 0.985959076324099 1 GO:0036408 histone H3K14 acetyltransferase activity 1/2632 28/18639 0.0357142857142857 0.2529173903604 0.985959076324099 1 GO:0046875 ephrin receptor binding 1/2632 28/18639 0.0357142857142857 0.2529173903604 0.985959076324099 1 GO:0141052 histone H3 demethylase activity 1/2632 28/18639 0.0357142857142857 0.2529173903604 0.985959076324099 1 GO:0035401 histone H3Y41 kinase activity 9/2632 115/18639 0.0782608695652174 0.554218977137571 0.986769851159875 1 GO:0140801 histone H2AXY142 kinase activity 9/2632 115/18639 0.0782608695652174 0.554218977137571 0.986769851159875 1 GO:0031492 nucleosomal DNA binding 2/2632 42/18639 0.0476190476190476 0.337223187147199 0.986850995464585 1 GO:0004896 cytokine receptor activity 7/2632 96/18639 0.0729166666666667 0.516373005319149 0.987180048212049 1 GO:0004181 metallocarboxypeptidase activity 1/2632 29/18639 0.0344827586206897 0.244196101037627 0.987944768179183 1 GO:0010484 histone H3 acetyltransferase activity 1/2632 29/18639 0.0344827586206897 0.244196101037627 0.987944768179183 1 GO:0099604 ligand-gated calcium channel activity 1/2632 29/18639 0.0344827586206897 0.244196101037627 0.987944768179183 1 GO:0106222 lncRNA binding 1/2632 29/18639 0.0344827586206897 0.244196101037627 0.987944768179183 1 GO:0022836 gated channel activity 32/2632 318/18639 0.10062893081761 0.712622584160119 0.988091245329782 1 GO:0008235 metalloexopeptidase activity 4/2632 66/18639 0.0606060606060606 0.429193147278254 0.988272034126566 1 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 1/2632 30/18639 0.0333333333333333 0.236056231003039 0.989649731647877 1 GO:0031624 ubiquitin conjugating enzyme binding 1/2632 30/18639 0.0333333333333333 0.236056231003039 0.989649731647877 1 GO:0043995 histone H4K5 acetyltransferase activity 1/2632 30/18639 0.0333333333333333 0.236056231003039 0.989649731647877 1 GO:0043996 histone H4K8 acetyltransferase activity 1/2632 30/18639 0.0333333333333333 0.236056231003039 0.989649731647877 1 GO:0043997 histone H4K12 acetyltransferase activity 1/2632 30/18639 0.0333333333333333 0.236056231003039 0.989649731647877 1 GO:0001223 transcription coactivator binding 2/2632 44/18639 0.0454545454545455 0.32189486045869 0.989905291646235 1 GO:0003777 microtubule motor activity 4/2632 68/18639 0.0588235294117647 0.416569819417129 0.990620787582562 1 GO:0008327 methyl-CpG binding 1/2632 31/18639 0.032258064516129 0.228441513873909 0.991113641922625 1 GO:0140303 intramembrane lipid transporter activity 2/2632 45/18639 0.0444444444444444 0.314741641337386 0.991160552153859 1 GO:0005126 cytokine receptor binding 26/2632 275/18639 0.0945454545454545 0.669541309754076 0.992535484603682 1 GO:0035173 histone kinase activity 36/2632 360/18639 0.1 0.708168693009119 0.992591973994311 1 GO:0033192 calmodulin-dependent protein phosphatase activity 5/2632 81/18639 0.0617283950617284 0.437141168524147 0.992601037477597 1 GO:0140791 histone H2AXS140 phosphatase activity 5/2632 81/18639 0.0617283950617284 0.437141168524147 0.992601037477597 1 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 5/2632 81/18639 0.0617283950617284 0.437141168524147 0.992601037477597 1 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 5/2632 81/18639 0.0617283950617284 0.437141168524147 0.992601037477597 1 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 5/2632 81/18639 0.0617283950617284 0.437141168524147 0.992601037477597 1 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 5/2632 81/18639 0.0617283950617284 0.437141168524147 0.992601037477597 1 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 5/2632 81/18639 0.0617283950617284 0.437141168524147 0.992601037477597 1 GO:1990439 MAP kinase serine/threonine phosphatase activity 5/2632 81/18639 0.0617283950617284 0.437141168524147 0.992601037477597 1 GO:0061733 protein-lysine-acetyltransferase activity 2/2632 47/18639 0.0425531914893617 0.30134838000388 0.993230083923274 1 GO:0061749 forked DNA-dependent helicase activity 2/2632 47/18639 0.0425531914893617 0.30134838000388 0.993230083923274 1 GO:0099095 ligand-gated monoatomic anion channel activity 2/2632 47/18639 0.0425531914893617 0.30134838000388 0.993230083923274 1 GO:0140938 histone H3 methyltransferase activity 2/2632 47/18639 0.0425531914893617 0.30134838000388 0.993230083923274 1 GO:1990518 single-stranded 3'-5' DNA helicase activity 2/2632 47/18639 0.0425531914893617 0.30134838000388 0.993230083923274 1 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 5/2632 82/18639 0.0609756097560976 0.431810178664097 0.99335275639942 1 GO:0033549 MAP kinase phosphatase activity 5/2632 82/18639 0.0609756097560976 0.431810178664097 0.99335275639942 1 GO:0141003 histone H2AX kinase activity 35/2632 354/18639 0.0988700564971751 0.700166786873422 0.993527676087049 1 GO:0005125 cytokine activity 21/2632 234/18639 0.0897435897435897 0.635536006546645 0.993710042155498 1 GO:0042379 chemokine receptor binding 4/2632 72/18639 0.0555555555555556 0.393427051671733 0.99403957961878 1 GO:0009378 four-way junction helicase activity 2/2632 48/18639 0.0416666666666667 0.295070288753799 0.994078627557118 1 GO:0036121 double-stranded DNA helicase activity 2/2632 48/18639 0.0416666666666667 0.295070288753799 0.994078627557118 1 GO:0043138 3'-5' DNA helicase activity 2/2632 48/18639 0.0416666666666667 0.295070288753799 0.994078627557118 1 GO:0016410 N-acyltransferase activity 6/2632 94/18639 0.0638297872340425 0.45202257000582 0.994259710353408 1 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 1/2632 34/18639 0.0294117647058824 0.208284909708564 0.994376362265385 1 GO:0140996 histone H3 kinase activity 35/2632 357/18639 0.0980392156862745 0.694283032361881 0.994549719201489 1 GO:0017018 myosin phosphatase activity 5/2632 84/18639 0.0595238095238095 0.421528983933999 0.994642991590733 1 GO:0015081 sodium ion transmembrane transporter activity 13/2632 164/18639 0.0792682926829268 0.561353232263326 0.994847242922623 1 GO:0010485 histone H4 acetyltransferase activity 1/2632 35/18639 0.0285714285714286 0.20233391228832 0.99517192337893 1 GO:0015085 calcium ion transmembrane transporter activity 11/2632 147/18639 0.0748299319727891 0.529922151231313 0.995663826618547 1 GO:0070851 growth factor receptor binding 10/2632 139/18639 0.0719424460431655 0.509473879862675 0.996287592528067 1 GO:0030280 structural constituent of skin epidermis 1/2632 37/18639 0.027027027027027 0.191396944056519 0.996441423979036 1 GO:0005262 calcium channel activity 9/2632 131/18639 0.0687022900763359 0.486528109700921 0.996898474750808 1 GO:0099094 ligand-gated monoatomic cation channel activity 9/2632 136/18639 0.0661764705882353 0.46864104684427 0.998074712142866 1 GO:0015276 ligand-gated monoatomic ion channel activity 14/2632 186/18639 0.0752688172043011 0.533030199039122 0.998183210038196 1 GO:0004402 histone acetyltransferase activity 1/2632 42/18639 0.0238095238095238 0.1686115935736 0.998340550103451 1 GO:0022834 ligand-gated channel activity 14/2632 188/18639 0.074468085106383 0.52735966500679 0.998467560872874 1 GO:0046873 metal ion transmembrane transporter activity 43/2632 450/18639 0.0955555555555556 0.67669452887538 0.998736505398851 1 GO:0043014 alpha-tubulin binding 1/2632 44/18639 0.0227272727272727 0.160947430229345 0.998777039703734 1 GO:0004715 non-membrane spanning protein tyrosine kinase activity 1/2632 45/18639 0.0222222222222222 0.157370820668693 0.998950141693504 1 GO:0008009 chemokine activity 1/2632 45/18639 0.0222222222222222 0.157370820668693 0.998950141693504 1 GO:0042605 peptide antigen binding 1/2632 45/18639 0.0222222222222222 0.157370820668693 0.998950141693504 1 GO:0140375 immune receptor activity 9/2632 156/18639 0.0576923076923077 0.408558861351415 0.999739677504545 1 GO:0016755 aminoacyltransferase activity 45/2632 496/18639 0.0907258064516129 0.64249175777037 0.999784505019072 1 GO:0019787 ubiquitin-like protein transferase activity 43/2632 479/18639 0.0897703549060543 0.635725549047852 0.999791426143187 1 GO:0004842 ubiquitin-protein transferase activity 37/2632 449/18639 0.0824053452115813 0.583568856154507 0.999959134498002 1 GO:0003730 mRNA 3'-UTR binding 17/2632 262/18639 0.0648854961832061 0.459498770273092 0.999970724875477 1 GO:0061630 ubiquitin protein ligase activity 25/2632 353/18639 0.0708215297450425 0.501535901564532 0.999989324348923 1 GO:0061659 ubiquitin-like protein ligase activity 26/2632 372/18639 0.0698924731182796 0.49495661339347 0.999995167697111 1 GO:0003823 antigen binding 4/2632 174/18639 0.0229885057471264 0.162797400691751 0.999999987917531 1 GO:0045182 translation regulator activity 10/2632 356/18639 0.0280898876404494 0.198923790171101 0.999999999999953 1 GO:0030371 translation repressor activity 5/2632 329/18639 0.0151975683890578 0.107624421429957 1 1