category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	17/149	238/9376	4.49472674976031	RPS10/RPL23/NRP1/RPL6/PLCG2/RPL13A/RPL37A/PRKCA/RPS20/RPS11/RPL38/RPL31/RPS17/CYBB/F13A1/MMP1/MMP3	6.9394434017043
NA	NA	hsa04517	IgSF CAM signaling	14/149	299/9376	2.94637606338803	ITGA4/CADM1/NRP1/IL1RAPL2/PMP22/PLCG2/PRKCA/UNC5B/ARPC2/PLXNA2/AFDN/TUBA1B/PAK1/ANK3	4.34650009570966
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	11/149	205/9376	3.3765264364053	MT-ATP8/MMP9/MT-ND4/MT-ND4L/MT-ND5/COL3A1/MT-ATP6/PRKCA/MT-CO2/CYBB/PLCB2	4.3717945631501
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	12/149	248/9376	3.04481489499892	NAIP/PFN1/TCF7L2/HSP90AB1/TXN/NCKAP1L/PTPRC/PYCARD/ARPC2/TUBA1B/HSP90AA1/PAK1	4.14706208169769
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	11/149	216/9376	3.204573701218	MMP9/HSPA5/HSP90AB1/PYCARD/PRKCA/CYBB/POU2F2/PLCB2/HSP90AA1/MMP1/MMP3	4.16535741989365
Organismal Systems	Immune system	hsa04611	Platelet activation	8/149	126/9376	3.99531266645361	ITPR2/COL3A1/TLN1/PLCG2/TBXAS1/PTGS1/PLCB2/SNAP23	4.30135296007716
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	7/149	100/9376	4.4048322147651	HLA-DRB1/ITGA4/IL7R/IL2RA/HLA-DPB1/CD1D/CSF1R	4.34974560013516
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	5/149	50/9376	6.29261744966443	HLA-DRB1/ITGA4/HLA-DPB1/ITGB7/TNFSF13	4.76822030751482
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	7/149	106/9376	4.15550208940104	MMP9/FOLR3/TCF7L2/HSP90AB1/TGFA/HSP90AA1/MMP3	4.15173905791887
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	7/149	116/9376	3.79726915065957	MMP9/ITGA4/PLCG2/PRKCA/AFDN/CYBB/CLDN1	3.85217731290228
Genetic Information Processing	Translation	hsa03010	Ribosome	10/149	222/9376	2.83451236471371	RPS10/RPL23/RPL6/RPL13A/RPL37A/RPS20/RPS11/RPL38/RPL31/RPS17	3.51512026623617
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	11/149	268/9376	2.58279074426525	MT-ATP8/ITPR2/MT-ND4/MT-ND4L/MT-ND5/MT-ATP6/HSPA5/TXN/MT-CO2/TUBA1B/UBE2J1	3.34062633240912
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	8/149	160/9376	3.14630872483222	HLA-DRB1/ITGA9/ITGA4/CADM1/PTPRC/HLA-DPB1/ITGB7/CLDN1	3.47960111540329
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	6/149	95/9376	3.97428470505122	HLA-DRB1/FLT1/HLA-DPB1/TNFSF13/MMP1/MMP3	3.7025034016994
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	10/149	233/9376	2.70069418440533	ITGA9/ITGA4/TPM3/COL3A1/TLN1/DIAPH2/ITGB7/SYNE2/LBR/ANK3	3.34047587299312
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	6/149	100/9376	3.77557046979866	CX3CR1/IL2RA/CCR6/CSF1R/CXCL14/CCL24	3.54585033192442
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	5/149	75/9376	4.19507829977629	ITPR2/HSPA5/PRKCA/GPX7/PLCB2	3.53017168503978
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	10/149	254/9376	2.47740844474978	ITPR2/HRH2/SLC8A1/CAMK1/FLT1/CYSLTR1/PLCG2/PRKCA/TGFA/PLCB2	3.03333875290755
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	8/149	184/9376	2.73592063028888	SEMA6B/NRP1/PLCG2/PRKCA/UNC5B/DPYSL2/PLXNA2/PAK1	3.02191524951785
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	5/149	82/9376	3.83696185955148	HLA-DRB1/HSPA5/HSP90AB1/HLA-DPB1/HSP90AA1	3.27874469830844
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	8/149	187/9376	2.69202885547141	ITPR2/NAIP/HSP90AB1/TXN/PYCARD/CYBB/PLCB2/HSP90AA1	2.969907716301
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	8/149	193/9376	2.60833883923914	PLCG2/CX3CR1/DOCK2/CCR6/CXCL14/CCL24/PLCB2/PAK1	2.86888027260793
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	5/149	86/9376	3.65849851724676	ITGA9/ITGA4/SLC8A1/TCF7L2/ITGB7	3.14721420773434
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	10/149	275/9376	2.2882245271507	MT-ATP8/ITPR2/MT-ND4/MT-ND4L/MT-ND5/MT-ATP6/HSPA5/MT-CO2/CYBB/TUBA1B	2.75525542060047
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	12/149	362/9376	2.08595053580036	ITGA9/ITGA4/IL7R/YWHAH/FLT1/HSP90AB1/PRKCA/IL2RA/ITGB7/TGFA/CSF1R/HSP90AA1	2.67765157456604
NA	NA	hsa04981	Folate transport and metabolism	3/149	31/9376	6.08962978999784	FOLR3/SLCO2B1/ABCC4	3.60683188196007
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	8/149	201/9376	2.50452435807539	MMP9/FLT1/SPI1/ITGB7/CSF1R/SUPT3H/MMP3/MAF	2.73995056776156
Organismal Systems	Digestive system	hsa04970	Salivary secretion	5/149	93/9376	3.38312766110991	ITPR2/PRKCA/PLCB2/PRH1/PRB1	2.93489871922856
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	5/149	94/9376	3.34713694131087	MMP9/HSP90AB1/HSP90AA1/MMP1/MMP3	2.90623069685239
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	4/149	63/9376	3.99531266645361	HPGDS/TBXAS1/PTGS1/ALOX5	3.03121086104771
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	5/149	98/9376	3.21051910697165	PTPRC/PLCG2/PRKCA/ARPC2/PAK1	2.7953013805679
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	14/149	480/9376	1.83534675615213	MT-ATP8/ITPR2/MT-ND4/MT-ND4L/MT-ND5/MT-ATP6/HSPA5/PRKCA/GPX7/MT-CO2/CYBB/TUBA1B/UBE2J1/PLCB2	2.3874733590624
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	5/149	99/9376	3.17808962104264	ITGA9/ITGA4/TPM3/SLC8A1/ITGB7	2.7684588757537
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	5/149	101/9376	3.11515715329922	COL3A1/PLCG2/PRKCA/CYBB/PLCB2	2.71578184195365
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	6/149	138/9376	2.73592063028888	MT-ATP8/MT-ND4/MT-ND4L/MT-ND5/MT-ATP6/MT-CO2	2.6105315170985
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	6/149	139/9376	2.71623774805659	ITPR2/MMP9/HSP90AB1/TGFA/PLCB2/HSP90AA1	2.5904063159676
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	4/149	69/9376	3.64789417371851	ALOX5AP/PLCG2/PRKCA/ALOX5	2.80523225941394
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	6/149	142/9376	2.65885244352018	ITPR2/TYROBP/SPI1/PLCG2/LILRB1/CSF1R	2.53107786623271
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	5/149	105/9376	2.9964844998402	ITGA9/ITGA4/TPM3/SLC8A1/ITGB7	2.6142421578007
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	4/149	73/9376	3.44800956145996	EML4/PLCG2/PRKCA/TGFA	2.66815798684745
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	5/149	109/9376	2.88652176590111	HLA-DRB1/HSP90AB1/IL2RA/HLA-DPB1/HSP90AA1	2.51741027131585
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	6/149	149/9376	2.53393991261655	ITPR2/MT-ND4/MT-ND4L/MT-ND5/PRKCA/PLCB2	2.39838960824582
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	8/149	232/9376	2.16986808609118	ITGA9/ITGA4/PFN1/NCKAP1L/DIAPH2/ARPC2/ITGB7/PAK1	2.29277421790578
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	11/149	368/9376	1.88094543332361	MT-ATP8/MT-ND4/MT-ND4L/MT-ND5/MT-ATP6/PFN1/HSPA5/GPX7/MT-CO2/TUBA1B/HNRNPA3	2.19082274588501
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	4/149	76/9376	3.31190392087602	ITPR2/HRH2/PRKCA/PLCB2	2.57148275088462
Human Diseases	Cancer: specific types	hsa05214	Glioma	4/149	76/9376	3.31190392087602	CAMK1/PLCG2/PRKCA/TGFA	2.57148275088462
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	4/149	78/9376	3.22698330752022	HLA-DRB1/ITGA4/HLA-DPB1/CYBB	2.50967800378262
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	5/149	115/9376	2.73592063028888	ITPR2/PRKCA/PTGS1/ALOX5/PLCB2	2.3801172650822
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	6/149	157/9376	2.40482195528577	SIGLEC10/CX3CR1/P2RY6/MERTK/ALOX5/STAB1	2.25568118381157
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	7/149	200/9376	2.20241610738255	NAIP/NCKAP1L/PYCARD/ARPC2/TUBA1B/CLDN1/PAK1	2.18419592665497
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	7/149	203/9376	2.16986808609118	ITGA9/ITGA4/TLN1/FLT1/PRKCA/ITGB7/PAK1	2.14130103994707
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	11/149	388/9376	1.78398948315229	MT-ATP8/ITPR2/MT-ND4/MT-ND4L/MT-ND5/MT-ATP6/MT-CO2/CYBB/TUBA1B/PSENEN/PLCB2	2.00420933167998
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	4/149	86/9376	2.92679881379741	PLCG2/PRKCA/TGFA/PAK1	2.28100507218226
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	8/149	253/9376	1.98976045839191	ITPR2/TLN1/NAIP/PFN1/PLCG2/PYCARD/ARPC2/PLCB2	2.02800973181476
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	3/149	53/9376	3.56185893377232	SLC8A1/PRKCA/PLCB2	2.37664226900665
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	7/149	212/9376	2.07775104470052	TLN1/PFN1/FLT1/PRKCA/AFDN/CSF1R/PLCB2	2.01693710115721
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	4/149	89/9376	2.82814267400649	ITPR2/PRKCA/TUBA1B/PLCB2	2.20199272131048
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/149	24/9376	5.24384787472036	HS3ST3B1/HS3ST1	2.64521935421584
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	5/149	130/9376	2.42023748064017	MMP9/COL3A1/PRKCA/PLCB2/MMP1	2.07206900015121
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	4/149	91/9376	2.76598569216019	PLCG2/LILRB1/CARD11/BLK	2.15112394633458
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	9/149	308/9376	1.83875185217467	MT-ATP8/MT-ND4/MT-ND4L/MT-ND5/MT-ATP6/GPX7/MT-CO2/TUBA1B/PLCB2	1.90196099743612
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	4/149	93/9376	2.70650212888793	HLA-DRB1/IL2RA/HLA-DPB1/MAF	2.10161251290306
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	5/149	133/9376	2.36564565776858	TYROBP/PLCG2/PRKCA/LAT2/PAK1	2.0156071219628
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	7/149	224/9376	1.96644295302013	HLA-DRB1/TLN1/VAC14/SPI1/NRP1/IL2RA/HLA-DPB1	1.8603332109473
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	3/149	59/9376	3.19963599135479	GSTM4/HPGDS/GPX7	2.15371031142643
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	7/149	227/9376	1.94045472016084	MT-ATP8/MT-ND4/MT-ND4L/MT-ND5/GSTM4/MT-ATP6/MT-CO2	1.82268876841501
Organismal Systems	Nervous system	hsa04730	Long-term depression	3/149	60/9376	3.14630872483222	ITPR2/PRKCA/PLCB2	2.11934465239564
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	4/149	98/9376	2.56841528557732	ITPR2/PLCG2/PRKCA/PLCB2	1.98333205953796
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	4/149	98/9376	2.56841528557732	ITPR2/CAMK1/PRKCA/PLCB2	1.98333205953796
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	4/149	99/9376	2.54247169683411	ITPR2/PLCG2/PRKCA/PLCB2	1.96055727847191
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	5/149	142/9376	2.21571036960015	MMP9/GSTM4/HSP90AB1/TXN/HSP90AA1	1.85493147402239
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	4/149	103/9376	2.44373493190852	COL3A1/PRKCA/CD1D/PLCB2	1.87216645388795
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/149	30/9376	4.19507829977629	FOLR3/ABCC4	2.2272950748433
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	3/149	65/9376	2.9042849767682	ITPR2/PRKCA/PLCB2	1.95766766816171
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	7/149	238/9376	1.8507698381366	FLT1/PLCG2/PRKCA/AFDN/TGFA/CSF1R/PAK1	1.68936502404114
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	4/149	105/9376	2.39718759987216	ITPR2/PLCG2/PYCARD/PAK1	1.82950918288348
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	3/149	66/9376	2.86028065893838	HLA-DRB1/HLA-DPB1/MAF	1.92718812155886
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	3/149	67/9376	2.81758990283482	ITPR2/PRKCA/PLCB2	1.89727506805338
Human Diseases	Immune disease	hsa05310	Asthma	2/149	32/9376	3.93288590604027	HLA-DRB1/HLA-DPB1	2.11179741986446
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	3/149	68/9376	2.7761547572049	TCF7L2/SPI1/CSF1R	1.86790844037943
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	4/149	110/9376	2.2882245271507	FLT1/PLCG2/PRKCA/CYBB	1.72699177977224
NA	NA	hsa04518	Integrin signaling	5/149	154/9376	2.04305761352741	ITGA9/ITGA4/TLN1/FLT1/ITGB7	1.65845850948558
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	5/149	155/9376	2.02987659666594	HLA-DRB1/CORO1A/HLA-DPB1/CYBB/TUBA1B	1.64289776707753
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	8/149	298/9376	1.6892932750777	IL7R/CX3CR1/IL2RA/CCR6/CSF1R/CXCL14/CCL24/TNFSF13	1.53661686826656
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	6/149	204/9376	1.8507698381366	ITPR2/MMP9/PLCG2/PRKCA/PAK1/ANK3	1.56114649195447
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	4/149	116/9376	2.16986808609118	ITPR2/PRKCA/PLCB2/HOMER1	1.61104958357914
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	2/149	37/9376	3.40141483765645	PRKCA/PLCB2	1.85980056845916
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	2/149	37/9376	3.40141483765645	TPM3/TCF7L2	1.85980056845916
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	3/149	76/9376	2.48392794065701	SLC27A4/PLIN5/MMP1	1.65054225156093
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/149	38/9376	3.31190392087602	NMRK2/PNP	1.81460940360678
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	2/149	38/9376	3.31190392087602	IL7R/PTPRC	1.81460940360678
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/149	39/9376	3.22698330752022	HLA-DRB1/HLA-DPB1	1.77090024480846
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	4/149	122/9376	2.06315326218506	ITPR2/PLCG2/PRKCA/PLCB2	1.50196411280404
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	5/149	170/9376	1.8507698381366	ARPC2/CD1D/AFDN/TUBA1B/CLDN1	1.4224911470378
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	5/149	170/9376	1.8507698381366	GSTM4/TCF7L2/PLCG2/PRKCA/TGFA	1.4224911470378
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	3/149	80/9376	2.35973154362416	PLCG2/PRKCA/TGFA	1.55202467156712
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	2/149	41/9376	3.06956948764119	MMP9/MMP1	1.6875758124119
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	2/149	42/9376	2.9964844998402	SLC40A1/CYBB	1.64780266847403
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	5/149	174/9376	1.80822340507599	ERP29/HSPA5/HSP90AB1/UBE2J1/HSP90AA1	1.36745626297771
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	3/149	85/9376	2.22092380576392	NT5C3B/LACC1/PNP	1.4368628182708
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	2/149	44/9376	2.86028065893838	HLA-DRB1/HLA-DPB1	1.57168662038782
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	2/149	45/9376	2.79671886651752	HLA-DRB1/HLA-DPB1	1.53522064659939
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	3/149	87/9376	2.16986808609118	TPM3/SLC8A1/MT-CO2	1.39303026041371
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	3/149	87/9376	2.16986808609118	TCF7L2/TGFA/MSH3	1.39303026041371
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	4/149	134/9376	1.87839326855655	ITPR2/PRKCA/PPP1R14A/PLCB2	1.30138839055818
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	3/149	89/9376	2.12110700550486	ITGA9/ITGA4/ITGB7	1.35037024245031
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	6/149	235/9376	1.60662573182922	MT-ATP8/MT-ND4/MT-ND4L/MT-ND5/MT-ATP6/MT-CO2	1.19675821415484
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	4/149	138/9376	1.82394708685926	ITGA4/PYCARD/ARPC2/SKAP2	1.2390772948586
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	3/149	93/9376	2.02987659666594	ITPR2/PRKCA/PLCB2	1.26832630657756
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/149	13/9376	4.84047496128033	PRKDC	1.76074966546641
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/149	51/9376	2.46769311751546	PLD4/PAFAH1B3	1.33550167667561
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	2/149	51/9376	2.46769311751546	PLCG2/PRKCA	1.33550167667561
NA	NA	hsa04082	Neuroactive ligand signaling	5/149	199/9376	1.58105966071971	HRH2/P2RY13/PRKCA/P2RY6/PLCB2	1.05279887121901
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/149	54/9376	2.33059905543127	HLA-DRB1/HLA-DPB1	1.24605741388385
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	3/149	101/9376	1.86909429197953	TCF7L2/PRKCA/PLCB2	1.11588422327014
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/149	55/9376	2.2882245271507	ACER3/NEU4	1.21755942400378
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	3/149	102/9376	1.8507698381366	ITPR2/PRKCA/PLCB2	1.09780988482421
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	2/149	56/9376	2.24736337488015	NAIP/PYCARD	1.18967286936968
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	4/149	154/9376	1.63444609082193	TPM3/SLC8A1/PRKCA/PLCB2	1.00876740123218
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	4/149	154/9376	1.63444609082193	ITPR2/CAMK1/PRKCA/PLCB2	1.00876740123218
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	2/149	60/9376	2.09753914988814	PLCG2/PRKCA	1.08375076763112
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/149	18/9376	3.49589858314691	NEU4	1.34685294033113
Organismal Systems	Digestive system	hsa04978	Mineral absorption	2/149	61/9376	2.06315326218506	SLC8A1/SLC40A1	1.05856584229242
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	5/149	214/9376	1.47023772188421	ITPR2/SAMHD1/PLCG2/PRKCA/PAK1	0.884255398258902
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	3/149	112/9376	1.68552253116011	HLA-DRB1/HLA-DPB1/ALOX5	0.92742753033505
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/149	20/9376	3.14630872483222	LBR	1.22098574717137
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	3/149	115/9376	1.64155237817333	ITPR2/PRKCA/PLCB2	0.879631168097112
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	3/149	115/9376	1.64155237817333	ITPR2/PRKCA/PLCB2	0.879631168097112
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	2/149	65/9376	1.93618998451213	ITPR2/PLCB2	0.962434134751518
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	4/149	168/9376	1.4982422499201	HSP90AB1/PYCARD/CYBB/HSP90AA1	0.828058557476481
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	4/149	173/9376	1.45494045078946	HLA-DRB1/PYCARD/PRKCA/HLA-DPB1	0.767469996686576
Organismal Systems	Endocrine system	hsa04924	Renin secretion	2/149	69/9376	1.82394708685926	ITPR2/PLCB2	0.872906089317692
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/149	70/9376	1.79789069990412	GSTM4/HPGDS	0.851450512132626
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	2/149	70/9376	1.79789069990412	TGFA/PAK1	0.851450512132626
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	2/149	70/9376	1.79789069990412	HLA-DRB1/HLA-DPB1	0.851450512132626
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	3/149	122/9376	1.54736494663879	PTPRC/CARD11/PAK1	0.773286915160935
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	3/149	122/9376	1.54736494663879	PLCG2/PRKCA/PLCB2	0.773286915160935
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/149	23/9376	2.73592063028888	MSH3	1.05917281964849
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	2/149	71/9376	1.77256829568012	PLCG2/PAK1	0.830340802632638
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	4/149	178/9376	1.41407133700324	TCF7L2/PRKCA/TBL1XR1/PLCB2	0.708740057186316
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/149	73/9376	1.72400478072998	GSTM4/HPGDS	0.789114212882549
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	3/149	128/9376	1.4748322147651	PGM2/LACC1/PNP	0.68733706196025
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	2/149	75/9376	1.67803131991051	GSTM4/MSH3	0.749141880900333
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	6/149	300/9376	1.25852348993289	FLT1/PRKCA/TGFA/CSF1R/MECOM/PAK1	0.578311603002353
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	2/149	78/9376	1.61349165376011	PLCG2/PLCB2	0.691368679660384
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	3/149	133/9376	1.41938739466115	ITPR2/PRKCA/PLCB2	0.618989424329631
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/149	79/9376	1.5930677087758	GSTM4/HPGDS	0.672658943087061
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/149	29/9376	2.16986808609118	PAK1	0.801767196067269
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	4/149	195/9376	1.29079332300809	PLCG2/PRKCA/CYBB/PLCB2	0.52144109416441
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	2/149	83/9376	1.51629336136492	SAMHD1/PYCARD	0.600352233277565
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	3/149	140/9376	1.34841802492809	ITPR2/SLC8A1/PLCB2	0.527802183272665
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/149	31/9376	2.02987659666594	PGM2	0.72983535082241
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/149	31/9376	2.02987659666594	HSPA5	0.72983535082241
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	3/149	143/9376	1.32012953489464	HLA-DRB1/HLA-DPB1/SNRPD3	0.490197234389537
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	2/149	86/9376	1.4633994068987	PRKCA/PLCB2	0.548586801078098
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/149	32/9376	1.96644295302013	PGM2	0.695878325996527
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	3/149	144/9376	1.31096196868009	ITPR2/PRKCA/PLCB2	0.47784730101711
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	2/149	88/9376	1.43014032946919	F13A1/PROCR	0.515156172982842
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/149	33/9376	1.90685377262558	SNAP23	0.663131367866732
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	2/149	89/9376	1.41407133700324	SLC12A5/PRKCA	0.498747763590144
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	2/149	90/9376	1.39835943325876	EML4/BATF3	0.482536903529994
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	3/149	149/9376	1.26696995630827	PLCG2/PRKCA/PLCB2	0.417420502365966
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	2/149	93/9376	1.35325106444396	TCF7L2/AFDN	0.435040100252061
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/149	36/9376	1.74794929157345	PGM2	0.571345063722467
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/149	37/9376	1.70070741882822	PGM2	0.542670110730247
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	3/149	155/9376	1.21792595799957	ITPR2/TCF7L2/PLCB2	0.347643660361623
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	4/149	217/9376	1.15992948380911	GSTM4/HSP90AB1/PRKCA/HSP90AA1	0.302888570142018
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/149	38/9376	1.65595196043801	PGM2	0.514855563406842
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/149	38/9376	1.65595196043801	PRKCA	0.514855563406842
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	2/149	97/9376	1.29744689683803	PRKCA/PLCB2	0.374190910929884
NA	NA	hsa04519	Cadherin signaling	7/149	404/9376	1.09030500365473	YWHAH/TCF7L2/NCKAP1L/ARPC2/LIMA1/AFDN/PSENEN	0.235779681519405
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	2/149	99/9376	1.27123584841706	HLA-DRB1/HLA-DPB1	0.344754083908325
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	4/149	226/9376	1.11373760171052	AFDN/ABCC4/FFAR2/PAK1	0.219935963953374
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	2/149	103/9376	1.22186746595426	COL3A1/SLC8A1	0.287707125309765
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	3/149	166/9376	1.13722002102369	ITPR2/SLC8A1/PLCB2	0.226668005166438
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/149	43/9376	1.4633994068987	SLC27A4	0.38701480641707
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	2/149	105/9376	1.19859379993608	PLCG2/CARD11	0.26004323304904
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	1/149	44/9376	1.43014032946919	MAN2A1	0.363410648531786
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	2/149	107/9376	1.17619017750737	ITPR2/PLCB2	0.23291939478283
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/149	45/9376	1.39835943325876	ABCC4	0.340381368562046
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	2/149	110/9376	1.14411226357535	HSP90AB1/HSP90AA1	0.193196674425596
NA	NA	hsa03272	Virion - Hepatitis viruses	1/149	48/9376	1.31096196868009	CLDN1	0.274461946592315
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/149	48/9376	1.31096196868009	PLCB2	0.274461946592315
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	1/149	49/9376	1.28420764278866	XXYLT1	0.253461100584403
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	3/149	180/9376	1.04876957494407	HLA-DRB1/HLA-DPB1/POU2F2	0.08395261993119
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	3/149	181/9376	1.04297526790018	HLA-DRB1/CORO1A/HLA-DPB1	0.0741874639788006
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/149	52/9376	1.21011874032008	ALOX5	0.193069574741717
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	1/149	52/9376	1.21011874032008	APOC2	0.193069574741717
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	2/149	119/9376	1.05758276464948	MMP9/MMP3	0.0803302971033847
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	2/149	120/9376	1.04876957494407	PLCG2/SH2B2	0.0683244953470257
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	1/149	54/9376	1.16529952771564	LACC1	0.15479696996689
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	1/149	56/9376	1.12368168744008	MAN2A1	0.117961414410983
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	2/149	125/9376	1.00681879194631	PRKCA/PLCB2	0.00975251479126268
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	3/149	196/9376	0.963155732091494	ITPR2/TCF7L2/PLCG2	-0.0662407343977858
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/149	59/9376	1.0665453304516	NT5C3B	0.0651559462266361
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1/149	59/9376	1.0665453304516	PTGS1	0.0651559462266361
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	1/149	59/9376	1.0665453304516	TCF7L2	0.0651559462266361
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	2/149	133/9376	0.946258263107433	IL7R/HOMER1	-0.079319424486952
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	1/149	62/9376	1.01493829833297	PSENEN	0.0149960668767496
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/149	63/9376	0.998828166613401	MECOM	-0.00118587756416128
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	1/149	63/9376	0.998828166613401	TCF7L2	-0.00118587756416128
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	3/149	205/9376	0.920870846292356	HLA-DRB1/PLCG2/HLA-DPB1	-0.145563877879266
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	2/149	137/9376	0.918630284622544	ITPR2/TUBA1B	-0.121915551898824
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	2/149	138/9376	0.911973543429628	ITPR2/YWHAH	-0.132376927381305
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	1/149	67/9376	0.939196634278273	PGM2	-0.0634690529792448
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/149	68/9376	0.925384919068298	DHRS4L2	-0.078469592183088
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/149	69/9376	0.911973543429628	PRKCA	-0.0932569957304346
NA	NA	hsa04081	Hormone signaling	3/149	219/9376	0.86200239036499	HAMP/SLC40A1/PLCB2	-0.262582347206002
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	1/149	73/9376	0.86200239036499	SAMHD1	-0.150407674099899
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	3/149	227/9376	0.831623451497502	ITPR2/PRKCA/PLCB2	-0.326329420482363
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	1/149	77/9376	0.817223045410965	TGFA	-0.204643138494611
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	1/149	77/9376	0.817223045410965	MECOM	-0.204643138494611
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	2/149	156/9376	0.806745826880055	YWHAH/CLDN1	-0.309295948786261
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	1/149	78/9376	0.806745826880055	ARPC2	-0.217785982400732
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	1/149	78/9376	0.806745826880055	PYCARD	-0.217785982400732
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	2/149	157/9376	0.80160731842859	YWHAH/TCF7L2	-0.318553277974303
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	2/149	158/9376	0.796533854387902	YWHAH/PRKDC	-0.327756159216787
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1/149	82/9376	0.767392371910296	GSTM4	-0.268830201159557
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	2/149	163/9376	0.772100300572323	MMP9/PRKCA	-0.372979988408164
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	1/149	83/9376	0.758146680682461	MBD5	-0.281229996825873
Genetic Information Processing	Transcription	hsa03040	Spliceosome	3/149	243/9376	0.776866351810423	HNRNPA3/SNRPD3/RBMX	-0.447826703082548
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/149	86/9376	0.731699703449352	PLCB2	-0.317622334473981
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	2/149	168/9376	0.749121124960051	IL7R/IL2RA	-0.416950588594636
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	3/149	250/9376	0.755114093959732	FOLR3/IL2RA/ARPC2	-0.4987031082493
Organismal Systems	Digestive system	hsa04976	Bile secretion	1/149	90/9376	0.699179716629381	ABCC4	-0.364386721984275
Human Diseases	Substance dependence	hsa05032	Morphine addiction	1/149	91/9376	0.691496423040047	PRKCA	-0.375784149823243
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	4/149	333/9376	0.755869963923655	ITGA9/ITGA4/TCF7L2/ITGB7	-0.576415404594068
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	1/149	99/9376	0.635617924208528	MMP9	-0.463147513373468
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	1/149	99/9376	0.635617924208528	PRKCA	-0.463147513373468
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	1/149	103/9376	0.610933732977129	PLCB2	-0.504522538979326
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	1/149	104/9376	0.605059370160041	PLD4	-0.514647994460596
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	1/149	105/9376	0.599296899968041	CCZ1B	-0.52468974186818
Cellular Processes	Cell motility	hsa04814	Motor proteins	2/149	194/9376	0.648723448419013	TPM3/TUBA1B	-0.628246233518614
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	1/149	109/9376	0.577304353180223	SLC27A4	-0.564053053708781
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	1/149	110/9376	0.572056131787675	HAMP	-0.573700878247727
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	2/149	205/9376	0.613913897528237	YWHAH/VAC14	-0.710233683007936
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	4/149	370/9376	0.68028296753129	HRH2/P2RY13/CYSLTR1/P2RY6	-0.797350326000733
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	1/149	117/9376	0.53783055125337	TFPT	-0.639235130337336
NA	NA	hsa04382	Cornified envelope formation	2/149	217/9376	0.579964741904556	SLC27A4/CLDN1	-0.795499839701944
Human Diseases	Infectious disease: viral	hsa05162	Measles	1/149	136/9376	0.462692459534149	IL2RA	-0.802056413796522
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	1/149	138/9376	0.455986771714814	SH2B2	-0.818104038501255
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	3/149	323/9376	0.584453633095767	MMP9/PLCG2/PRKCA	-0.965768425749074
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	1/149	142/9376	0.44314207392003	UBE2J1	-0.849654094818903
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	1/149	144/9376	0.436987322893363	TCF7L2	-0.865167175702442
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	1/149	148/9376	0.425176854707056	TCF7L2	-0.895694327048468
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	1/149	150/9376	0.419507829977629	TCF7L2	-0.910717711221437
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	1/149	157/9376	0.400803659214295	ITPR2	-0.962111893420772
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	1/149	157/9376	0.400803659214295	MT-CO2	-0.962111893420772
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	1/149	158/9376	0.398266927193951	PRKCA	-0.969309760222338
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/149	449/9376	0.140147381952437	SLC8A1	-2.37270056206592