category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	107/1023	222/9376	4.41746144971951	RPL27A/RPS10/RPL31/UBA52/MRPS18C/MRPS21/RSL24D1/MRPL34/RPL19/RPL38/RPL41/MRPL2/MRPL15/RPL26/RPL37/RPL13A/MRPL52/RPS25/MRPL36/RPS8/MRPS15/MRPL14/MRPS34/RPS15/RPL35A/MRPL33/RPS6/MRPS18A/MRPL27/MRPL41/RACK1/RPL6/MRPL40/MRPL13/RPS12/MRPL54/MRPL21/MRPS14/RPS21/RPS13/MRPS35/MRPS12/MRPS7/FAU/RPL30/RPL26L1/MRPS17/RPL34/RPS26/MRPL55/MRPL11/MRPS18B/RPS3/MRPL24/RPL10/RPL14/MRPL46/RPL5/MRPL51/RPL17/RPS20/MRPL22/RPLP2/MRPS16/MRPL16/RPS16/MRPL20/RPL27/MRPL12/MRPL9/RPSA/RPL36/RPL23/RPL36AL/RPS27/RPL36A/RPS27L/RPL35/MRPL48/MRPL43/RPL32/RPS24/RPL21/MRPS23/MRPL45/RPL22/RPS18/RPS3A/RPL37A/RPL9/RPL8/RPS5/RPS9/RPL28/RPL18A/RPL24/MRPL28/RPL7/MRPL10/RPL29/RPS2/RPL7A/MRPL30/RPS14/RPL23A/RPS23/RPS15A	18.0333691017081
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	67/1023	138/9376	4.44977120432941	NDUFA3/NDUFS5/NDUFB7/ATP5MF/COX5B/COX8A/COX6B1/NDUFA7/COX7B/UQCRQ/NDUFA2/ATP6V1C2/NDUFB2/ATP5PD/COX7C/NDUFB9/UQCR11/ATP5MC1/NDUFB4/ATP5ME/UQCR10/NDUFB8/NDUFB11/ATP6V1G1/COX6C/NDUFA6/NDUFC1/COX17/NDUFV3/NDUFA11/NDUFB3/NDUFB10/NDUFB5/ATP5PF/UQCRFS1/NDUFS4/ATP6V0D1/COX7A2/NDUFS3/ATP6V1F/COX5A/ATP5PO/NDUFS6/UQCRH/NDUFA1/ATP5MG/ATP6V1D/ATP6V1E1/UQCRB/NDUFA12/ATP5F1D/NDUFA5/CYCS/MT-ATP8/NDUFS8/UQCRC2/COX6A1/NDUFB1/COX4I1/NDUFAB1/NDUFS7/ATP5MC2/NDUFA4/ATP5F1E/MT-ATP6/COX15/MT-ND1	14.2870666700975
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	82/1023	235/9376	3.19806992367047	GNAS/NDUFA3/NDUFS5/NDUFB7/ATP5MF/COX5B/COX8A/COX6B1/NDUFA7/COX7B/UQCRQ/NDUFA2/NDUFB2/ATP5PD/COX7C/NDUFB9/UQCR11/ATP5MC1/NDUFB4/ATP5ME/UQCR10/NDUFB8/NDUFB11/COX14/RPS6KB2/COX6C/NDUFA6/NDUFC1/COX17/NDUFV3/MGLL/NDUFA11/NDUFB3/NDUFB10/NDUFB5/RPS6/ATP5PF/UQCRFS1/NDUFS4/RHEB/COA6/COX7A2/NDUFS3/COA5/COX5A/ATP5PO/NDUFS6/UQCRH/NDUFA1/NDUFAF8/ATP5MG/UQCRB/NDUFA12/ATP5F1D/NDUFA5/MT-ATP8/PRKACB/NDUFS8/UQCRC2/COX6A1/NDUFB1/ACSL1/COX4I1/NDUFAB1/NDUFS7/ATP5MC2/NDUFAF1/PRKAG1/ACTG1/CREB3/NDUFA4/CPT2/ATP5F1E/PRKAA2/RPS6KA2/MT-ATP6/KDM3A/RPS6KA6/PPARGC1A/ADCY10/COX15/MT-ND1	11.9421025108057
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	96/1023	308/9376	2.85668583615798	NDUFA3/NDUFS5/TUBA1C/NDUFB7/COX5B/COX8A/COX6B1/NDUFA7/TUBB4B/COX7B/UQCRQ/NDUFA2/NDUFB2/SLC25A4/ATP5PD/COX7C/NDUFB9/UQCR11/ATP5MC1/NDUFB4/UQCR10/SLC25A6/NDUFB8/CLTB/DCTN3/NDUFB11/POLR2L/POLR2F/COX6C/NDUFA6/VDAC2/WIPI2/NDUFC1/TUBA1B/NDUFV3/PSMC3/NDUFA11/HAP1/NDUFB3/WIPI1/NDUFB10/POLR2K/NDUFB5/POLR2H/ATP5PF/UQCRFS1/POLR2I/NDUFS4/PSMD4/PSMB6/COX7A2/NDUFS3/DCTN2/NRBF2/COX5A/ATP5PO/NDUFS6/UQCRH/NDUFA1/UQCRB/NDUFA12/ATP5F1D/NDUFA5/CLTA/CYCS/MT-ATP8/ADRM1/AP2S1/PSMB3/NDUFS8/VDAC1/UQCRC2/SEM1/COX6A1/NDUFB1/COX4I1/NDUFAB1/PSMC5/PSMD8/REST/ACTR1A/NDUFS7/ATP5MC2/CREB3/NDUFA4/POLR2C/ATP5F1E/TUBB2A/ATG14/MT-ATP6/POLR2D/TUBB8/PPARGC1A/MAP2K7/KLC3/MT-ND1	11.5947193566443
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	71/1023	205/9376	3.17428891590969	NDUFA3/NDUFS5/GAPDH/MPC1/NDUFB7/COX5B/COX8A/COX6B1/NDUFA7/COX7B/UQCRQ/NDUFA2/NDUFB2/SLC25A4/ATP5PD/COX7C/PDK4/NDUFB9/UQCR11/ATP5MC1/NDUFB4/UQCR10/SLC25A6/NDUFB8/NDUFB11/COX6C/NDUFA6/VDAC2/NDUFC1/ACE/NDUFV3/NDUFA11/NDUFB3/NDUFB10/NDUFB5/ATP5PF/UQCRFS1/NDUFS4/COX7A2/NDUFS3/COX5A/ATP5PO/NDUFS6/UQCRH/NDUFA1/UQCRB/NDUFA12/RAC1/ATP5F1D/NDUFA5/MT-ATP8/NDUFS8/VDAC1/UQCRC2/COX6A1/NDUFB1/COX4I1/NDUFAB1/CD36/NDUFS7/ATP5MC2/PTPA/NDUFA4/CPT2/ATP5F1E/G6PD/MT-ATP6/CAMK2B/NOS3/MT-ND1/IRS1	11.0150900030992
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	83/1023	268/9376	2.83847624049839	GNAS/NDUFA3/NDUFS5/TUBA1C/NDUFB7/COX5B/UBA52/COX8A/COX6B1/NDUFA7/TUBB4B/COX7B/UQCRQ/NDUFA2/NDUFB2/SLC25A4/ATP5PD/COX7C/NDUFB9/UQCR11/ATP5MC1/NDUFB4/UQCR10/SLC25A6/NDUFB8/NDUFB11/COX6C/NDUFA6/VDAC2/NDUFC1/TUBA1B/NDUFV3/PSMC3/NDUFA11/NDUFB3/NDUFB10/NDUFB5/ATP5PF/UQCRFS1/NDUFS4/PSMD4/TXN2/PSMB6/COX7A2/NDUFS3/COX5A/ATP5PO/NDUFS6/UQCRH/NDUFA1/UQCRB/PARK7/NDUFA12/ATP5F1D/NDUFA5/CYCS/MT-ATP8/ADRM1/PRKACB/SLC39A4/PSMB3/NDUFS8/PINK1/VDAC1/UQCRC2/SEM1/COX6A1/NDUFB1/COX4I1/NDUFAB1/PSMC5/PSMD8/NDUFS7/ATP5MC2/NDUFA4/ATP5F1E/TUBB2A/MT-ATP6/CAMK2B/TUBB8/KLC3/MAPT/MT-ND1	10.6860234292192
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	71/1023	227/9376	2.86664858044707	NDUFA3/NDUFS5/NDUFB7/AHR/COX5B/COX8A/COX6B1/AKR1A1/NDUFA7/COX7B/UQCRQ/NDUFA2/NDUFB2/SLC25A4/ATP5PD/COX7C/NDUFB9/UQCR11/ATP5MC1/NDUFB4/MGST2/UQCR10/SLC25A6/NDUFB8/SLC26A2/NDUFB11/COX6C/NDUFA6/VDAC2/NDUFC1/NDUFV3/NDUFA11/NDUFB3/NDUFB10/NDUFB5/ATP5PF/UQCRFS1/NDUFS4/COX7A2/NDUFS3/COX5A/ATP5PO/NDUFS6/UQCRH/NDUFA1/UQCRB/NDUFA12/RAC1/MET/ATP5F1D/NDUFA5/MT-ATP8/ACP1/NDUFS8/VDAC1/UQCRC2/COX6A1/NDUFB1/COX4I1/NDUFAB1/NDUFS7/ATP5MC2/NDUFA4/ATP5F1E/MAPK3/MT-ATP6/GSTM4/VEGFA/CHUK/MAP2K7/MT-ND1	9.96301750834623
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	80/1023	275/9376	2.66624011374744	NDUFA3/NDUFS5/TUBA1C/NDUFB7/COX5B/COX8A/COX6B1/NDUFA7/TUBB4B/COX7B/UQCRQ/NDUFA2/NDUFB2/SLC25A4/ATP5PD/COX7C/NDUFB9/UQCR11/ATP5MC1/NDUFB4/UQCR10/SLC25A6/NDUFB8/NDUFB11/COX6C/NDUFA6/VDAC2/NDUFC1/TUBA1B/NDUFV3/PSMC3/NDUFA11/NDUFB3/NDUFB10/NDUFB5/ATP5PF/UQCRFS1/NDUFS4/PSMD4/PSMB6/COX7A2/NDUFS3/COX5A/ATP5PO/NDUFS6/UQCRH/NDUFA1/UQCRB/NDUFA12/RAC1/ATP5F1D/NDUFA5/CYCS/MT-ATP8/ADRM1/PRKACB/PSMB3/NDUFS8/VDAC1/UQCRC2/SEM1/COX6A1/NDUFB1/COX4I1/NDUFAB1/PSMC5/PSMD8/CSNK2A1/NDUFS7/ATP5MC2/CREB3/HSPA1B/NDUFA4/ATP5F1E/TUBB2A/MAPK3/MT-ATP6/TUBB8/KLC3/MT-ND1	9.81435108399731
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	71/1023	238/9376	2.73415641916591	RPL27A/RPS10/RPL31/UBA52/RSL24D1/RPL19/RPL38/RPL41/RPL26/RPL37/RPL13A/RPS25/RPS8/ACE/RPS15/RPL35A/RPS6/RPL6/RPS12/RPS21/RPS13/FAU/RPL30/RPL26L1/RPL34/RPS26/RPS3/RPL10/RPL14/RPL5/C3/RPL17/RPS20/RPLP2/RPS16/RPL27/RPSA/IRAK4/RPL36/RPL23/RPL36AL/RPS27/RPL36A/RPS27L/RPL35/RPL32/RPS24/RPL21/RPL22/RPS18/RPS3A/RPL37A/RPL9/RPL8/RPS5/RPS9/RPL28/RPL18A/RPL24/RPL7/MAPK3/RPL29/RPS2/RPL7A/RPS14/RPL23A/IL6R/RPS23/RPS15A/CHUK/TLR4	9.48316667762266
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	94/1023	368/9376	2.34111096944197	NDUFA3/NDUFS5/MAP2K6/TUBA1C/NDUFB7/COX5B/COX8A/COX6B1/NDUFA7/TUBB4B/COX7B/MAP1LC3B/UQCRQ/NDUFA2/NDUFB2/ATP5PD/COX7C/NDUFB9/UQCR11/ATP5MC1/NDUFB4/MAP1LC3A/UQCR10/NDUFB8/DCTN3/NDUFB11/COX6C/NDUFA6/WIPI2/NDUFC1/TUBA1B/NDUFV3/PSMC3/NDUFA11/HAP1/NDUFB3/WIPI1/NDUFB10/NDUFB5/ATP5PF/UQCRFS1/NDUFS4/ANXA11/PSMD4/PSMB6/COX7A2/NDUFS3/DCTN2/NRBF2/COX5A/ATP5PO/NDUFS6/UQCRH/NDUFA1/UQCRB/NDUFA12/RAC1/ATP5F1D/NDUFA5/CYCS/MT-ATP8/ADRM1/PSMB3/SQSTM1/NDUFS8/PINK1/VDAC1/UQCRC2/SEM1/COX6A1/NDUFB1/COX4I1/RAB8A/NDUFAB1/PSMC5/PSMD8/ACTR1A/NDUFS7/ATP5MC2/ACTG1/NDUFA4/TOMM40/ATP5F1E/NXT2/TUBB2A/OPTN/NUP98/ATG14/MT-ATP6/FIG4/NUP210L/TUBB8/KLC3/MT-ND1	9.18494689599559
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	54/1023	157/9376	3.15236191792592	NDUFA3/NDUFS5/NDUFB7/COX5B/COX8A/COX6B1/NDUFA7/COX7B/UQCRQ/NDUFA2/NDUFB2/COX7C/NDUFB9/UQCR11/NDUFB4/UQCR10/NDUFB8/NDUFB11/COX6C/NDUFA6/NDUFC1/NDUFV3/NDUFA11/NDUFB3/NDUFB10/NDUFB5/UQCRFS1/NDUFS4/COX7A2/NDUFS3/COX5A/NDUFS6/UQCRH/NDUFA1/UQCRB/NDUFA12/RAC1/NDUFA5/CYCS/MLX/NDUFS8/UQCRC2/COX6A1/NDUFB1/CDC42/COX4I1/NDUFAB1/NDUFS7/PRKAG1/NDUFA4/PRKAA2/IL6R/LEPR/IRS1	9.51755581698594
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	94/1023	388/9376	2.22043514627485	NDUFA3/NDUFS5/GAPDH/TUBA1C/NDUFB7/COX5B/COX8A/COX6B1/NDUFA7/TUBB4B/COX7B/UQCRQ/NDUFA2/NDUFB2/SLC25A4/ATP5PD/COX7C/NDUFB9/UQCR11/ATP5MC1/NDUFB4/UQCR10/SLC25A6/NDUFB8/NDUFB11/COX6C/NDUFA6/VDAC2/WIPI2/NDUFC1/TUBA1B/NDUFV3/PSMC3/NDUFA11/NDUFB3/WIPI1/NDUFB10/NDUFB5/ATP5PF/UQCRFS1/NDUFS4/FRAT2/PSMD4/PSMB6/COX7A2/NDUFS3/NRBF2/COX5A/ATP5PO/NDUFS6/UQCRH/NDUFA1/UQCRB/NDUFA12/ATP5F1D/NDUFA5/CYCS/MT-ATP8/ADRM1/SLC39A4/PSMB3/NAE1/NDUFS8/VDAC1/UQCRC2/SEM1/COX6A1/NDUFB1/COX4I1/NDUFAB1/FADD/PSMC5/PSMD8/CSNK2A1/NDUFS7/ATP5MC2/NDUFA4/ATP5F1E/TUBB2A/MAPK3/ATG14/MT-ATP6/WNT2B/CDK5/TUBB8/CHUK/MAP2K7/BACE2/KLC3/MAPT/PSEN2/MT-ND1/FRAT1/IRS1	8.59213815046184
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	106/1023	480/9376	2.02398175301401	NDUFA3/NDUFS5/MAP2K6/TUBA1C/NDUFB7/COX5B/UBA52/COX8A/COX6B1/NDUFA7/TUBB4B/COX7B/MAP1LC3B/UQCRQ/NDUFA2/NDUFB2/SLC25A4/ATP5PD/COX7C/NDUFB9/UQCR11/ATP5MC1/NDUFB4/MAP1LC3A/UQCR10/SLC25A6/NDUFB8/DCTN3/NDUFB11/COX6C/NDUFA6/VDAC2/WIPI2/NDUFC1/TUBA1B/NDUFV3/PSMC3/NDUFA11/HAP1/NDUFB3/WIPI1/NDUFB10/NDUFB5/ATP5PF/UQCRFS1/NDUFS4/FRAT2/PSMD4/PSMB6/COX7A2/NDUFS3/DCTN2/NRBF2/COX5A/ATP5PO/NDUFS6/UQCRH/NDUFA1/UQCRB/PARK7/NDUFA12/RAC1/ATP5F1D/NDUFA5/CYCS/MT-ATP8/ADRM1/PSMB3/SQSTM1/NDUFS8/PINK1/VDAC1/UQCRC2/SEM1/COX6A1/NDUFB1/COX4I1/RAB8A/NDUFAB1/FADD/PSMC5/PSMD8/CSNK2A1/ACTR1A/NDUFS7/ATP5MC2/NDUFA4/TOMM40/ATP5F1E/TUBB2A/OPTN/MAPK3/ATG14/MT-ATP6/WNT2B/FIG4/CAMK2B/CDK5/TUBB8/MAP2K7/BAK1/KLC3/MAPT/PSEN2/MT-ND1/FRAT1	8.05967748829877
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	25/1023	83/9376	2.7606025274117	ECH1/PHYH/PRDX5/DECR2/PMVK/PEX16/HMGCL/SCP2/MPV17/ACSL1/ACAA1/PXMP2/PEX19/PEX2/ACOT8/MLYCD/AMACR/PEX11A/NUDT12/ACOX3/PECR/PEX11G/MPV17L2/CROT/EHHADH	5.63799404643582
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	35/1023	149/9376	2.15289942070631	NDUFA3/NDUFS5/NDUFB7/NDUFA7/NDUFA2/NDUFB2/NDUFB9/NDUFB4/NDUFB8/NDUFB11/NDUFA6/NDUFC1/NDUFV3/MGLL/NDUFA11/NDUFB3/NDUFB10/NDUFB5/NDUFS4/NDUFS3/NDUFS6/NDUFA1/NDUFA12/NDUFA5/PRKACB/NDUFS8/NDUFB1/GABRE/NDUFAB1/NDUFS7/GNG7/NDUFA4/MAPK3/DAGLB/MT-ND1	4.96428274581857
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	49/1023	248/9376	1.81086620628764	ANXA2/MAP2K6/GAPDH/TUBA1C/DYNLT3/MYL12B/CASP4/MYL12A/TUBB4B/DYNC1I1/ARPC1B/DYNLRB1/DCTN3/TUBA1B/TXN2/STX10/DCTN2/RIPK2/ARPC1A/RAC1/RAB9A/CYCS/RPS3/TRADD/ACBD3/CDC42/ARPC5L/GCC2/FADD/SKP1/IRAK4/ACTR1A/ACTG1/RILP/AHNAK/TUBB2A/MAPK3/VPS41/FYCO1/RIPK1/TLR5/TNFSF10/RIPK3/TUBB8/CHUK/TLR4/MAP2K7/BAK1/KLC3	4.52886567876708
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	12/1023	32/9376	3.43695014662757	PCCA/BCKDHB/ECHDC1/ACSS2/BCKDHA/MLYCD/MMUT/LDHC/ACADS/DBT/ACOX3/EHHADH	4.83233944456835
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	27/1023	116/9376	2.13327940135504	PCCA/GAPDH/PFKP/GCSH/FBP1/ESD/ACAT2/TKT/IDH3B/GPT2/TPI1/TALDO1/RPIA/FH/MDH2/IDH3G/ACSS2/SHMT1/ALDOA/G6PD/AMT/MMUT/ACADS/ACOX3/TKFC/ALDOC/PHGDH	4.2979633782388
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	15/1023	48/9376	2.86412512218964	PCCA/BCKDHB/HMGCL/BCAT2/ACAT2/HADH/ALDH3A2/ACAA1/HIBADH/BCKDHA/MMUT/ACADS/DBT/EHHADH/ALDH1B1	4.5310997562274
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	12/1023	34/9376	3.23477660859065	POLR3K/POLR2L/POLR2F/POLR2K/POLR2H/POLR2I/CRCP/POLR2M/POLR3H/POLR2C/POLR3F/POLR2D	4.56831306534643
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	34/1023	170/9376	1.83304007820137	TUBA1C/MYL6B/MYL12B/MYL12A/MYL6/PPP2R1B/ARPC1B/RAB13/TUBA1B/TJP1/ARPC1A/RAC1/RDX/PRKACB/CTTN/CLDN4/CDC42/RAB8A/ARPC5L/CLDN7/MYH14/CLDN1/WHAMM/HSPA4/PRKAG1/ACTG1/PRKAA2/CGN/CLDN15/PARD6A/AMOTL2/MAP2K7/RAPGEF6/CFTR	3.83580999015959
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	8/1023	19/9376	3.85903174358183	BCKDHB/GCSH/BCKDHA/DHTKD1/AMT/DBT/LIAS/LIPT1	4.36545662464637
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	11/1023	33/9376	3.05506679700228	VAMP5/STX19/STX18/VTI1B/VAMP8/STX4/VAMP7/USE1/STX7/VAMP4/STX3	4.1384904030553
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	10/1023	31/9376	2.9565162551635	PFKP/FBP1/DERA/TKT/TALDO1/RPIA/ALDOA/G6PD/PGM2/ALDOC	3.81835997393169
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	29/1023	154/9376	1.72591435934544	AKR1A1/RFK/PPCS/QPRT/MOCS2/NAPRT/UGT2B7/NME4/BCAT2/NME3/ALAS1/ALDH3A2/COASY/PDXK/RDH13/FLAD1/IDO2/SHMT1/NME2/UROD/MPI/COQ3/LIAS/NME6/COQ2/LIPT1/PANK1/COX15/ALDH1B1	3.17859651660764
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	17/1023	75/9376	2.07744542196155	GAPDH/ARG2/ASL/PFKP/BCAT2/TKT/IDH3B/GPT2/TPI1/TALDO1/RPIA/IDH3G/SHMT1/ALDOA/ALDOC/CTH/PHGDH	3.27841028895522
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	31/1023	169/9376	1.68119060426753	DEPTOR/UBA52/MAP1LC3B/GABARAPL1/MAP1LC3A/RPS6KB2/BNIP3/WIPI2/IGBP1/WIPI1/VAMP8/RHEB/SH3GLB1/NRBF2/PRKACB/SQSTM1/RAB8A/WDR45/RRAGD/STX7/PRKAA2/DAPK3/OPTN/MAPK3/VPS41/ATG14/CAMKK2/ATG4A/TP53INP2/IRS1/DAPK1	3.12719630407784
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	14/1023	57/9376	2.25110185042273	MECR/HSD17B8/SCP2/ACAT2/HADH/ACSL1/ACAA1/CPT2/ACADS/HACD1/ACOX3/MCAT/EHHADH/SCD	3.31548946863463
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	9/1023	31/9376	2.66086462964715	PCCA/GRHPR/GCSH/ACAT2/MDH2/ACSS2/SHMT1/AMT/MMUT	3.24136280862824
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	7/1023	21/9376	3.05506679700228	PPCS/BCAT2/ALDH3A2/COASY/VNN1/PANK1/ALDH1B1	3.29925518858245
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	11/1023	43/9376	2.34458614653663	ECI1/ACAT2/HADH/ALDH3A2/ACSL1/ACAA1/CPT2/ACADS/ACOX3/EHHADH/ALDH1B1	3.0925337045972
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	18/1023	87/9376	1.89624835676004	COX5B/COX8A/COX6B1/COX7B/UQCRQ/COX7C/UQCR11/UQCR10/COX6C/UQCRFS1/COX7A2/COX5A/UQCRH/UQCRB/TPM4/UQCRC2/COX6A1/COX4I1	2.93904158914961
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	34/1023	200/9376	1.55808406647116	GAPDH/TUBA1C/CASP4/TUBB4B/ARPC1B/TUBA1B/TJP1/ARPC1A/RAC1/CYCS/RPS3/CTTN/NCK1/TRADD/CLDN4/CDC42/ARPC5L/CLDN7/WASF2/MYH14/FADD/IRAK4/CLDN1/ACTG1/TUBB2A/MAPK3/RIPK1/TLR5/TNFSF10/CLDN15/TUBB8/CHUK/TLR4/BAK1	2.79183747904985
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	28/1023	158/9376	1.6242127275202	SGK1/DEPTOR/TBC1D7/LPIN2/ATP6V1C2/RNF152/LAMTOR4/ATP6V1G1/RPS6KB2/RPS6/RHEB/LAMTOR3/ATP6V1F/ATP6V1D/ATP6V1E1/LAMTOR2/LPIN3/RRAGD/MIOS/CASTOR2/CLIP1/PRKAA2/RPS6KA2/MAPK3/WNT2B/RPS6KA6/CHUK/IRS1	2.7691407171774
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	14/1023	63/9376	2.03671119800152	POLR2L/POLR2F/POLR2K/POLR2H/POLR2I/GTF2H5/RAD23A/POLR2M/RFC1/POLR2C/RFC5/ERCC5/XPC/POLR2D	2.889252363265
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	12/1023	51/9376	2.15651773906043	GNAS/ATP6V1C2/ATP6V1G1/TJP1/ATP6V0D1/ATP6V1F/ATP6V1D/ATP6V1E1/PRKACB/ACTG1/KCNQ1/CFTR	2.89811210367707
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	20/1023	105/9376	1.74575245542987	BNIP3L/FKBP8/UBA52/CITED2/MAP1LC3B/GABARAPL1/SAMM50/MAP1LC3A/BNIP3/FIS1/TFEB/TOMM7/SQSTM1/PINK1/FUNDC1/CSNK2A1/TOMM40/OPTN/MON1B/MTX3	2.68923196846204
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	40/1023	253/9376	1.44904354008013	MYL12B/CASP4/RPS6KA5/UBA52/MYL12A/MAP1LC3B/ARPC1B/MAP1LC3A/RPS6KB2/BNIP3/WIPI2/WIPI1/SHARPIN/UBE2D4/RIPK2/ARPC1A/FNBP1L/CAST/RAC1/CYCS/CTTN/SQSTM1/TRADD/C3/VDAC1/CDC42/ARPC5L/WASF2/RRAGD/SKP1/SEPTIN11/SEPTIN8/ACTG1/TLN1/MAPK3/ATG14/RIPK1/TLR5/CHUK/TLR4	2.53385693590185
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	11/1023	47/9376	2.14504690002288	AKR1A1/GRHPR/HAGH/ACAT2/LDHD/ALDH3A2/FH/MDH2/ACSS2/LDHC/ALDH1B1	2.75395520647513
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	14/1023	67/9376	1.91511649961337	GAPDH/AKR1A1/ALDH3B2/PFKP/FBP1/ALDH3A2/TPI1/ACSS2/ALDOA/LDHC/PGM2/BPGM/ALDOC/ALDH1B1	2.63065857693873
Genetic Information Processing	Transcription	hsa03040	Spliceosome	38/1023	243/9376	1.43324121340848	SYF2/SNRPD1/XAB2/CWC15/LSM3/LSM4/CCDC12/TXNL4A/PHF5A/BUD31/SNRPC/THOC7/SNRPG/SNRNP27/ZMAT2/LSM2/DDX46/SF3B5/BCAS2/SNRPE/SRSF8/SNU13/SNRPD3/SNRPD2/SNRPA1/CDC5L/NCBP2/PUF60/DHX16/HSPA1B/SNW1/WBP11/DDX23/RBMX2/YJU2/THOC5/SNIP1/DHX38	2.39457467915246
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	10/1023	44/9376	2.08300008886519	MPG/PARP4/SMUG1/NTHL1/RFC1/TDG/MBD4/RFC5/XRCC1/PARP2	2.5198209350509
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	38/1023	250/9376	1.39311045943304	DEPTOR/BLOC1S1/ATP6V1C2/CLTB/LAMTOR4/ATP6V1G1/AP1M2/VAMP8/ATP6V0D1/LAMTOR3/BORCS7/ATP6V1F/TFEB/KXD1/ATP6V1D/SNAPIN/ATP6V1E1/LAMTOR2/CLTA/AP2S1/BORCS8/VAMP7/BLOC1S5/RRAGD/BLOC1S2/HYAL3/CTSV/VPS41/AGA/FIG4/AP5S1/BORCS6/NEU1/SLC11A1/AP3B2/AP4E1/ACP2/DNASE2	2.2046851946924
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	8/1023	33/9376	2.2218667614562	BCKDHB/BCAT2/IDH3B/GPT2/IDH3G/BCKDHA/DHTKD1/DBT	2.46059343349565
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	7/1023	28/9376	2.29130009775171	ATP6V1C2/CA2/ATP6V1G1/ATP6V0D1/ATP6V1F/ATP6V1D/ATP6V1E1	2.39468868456481
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	9/1023	41/9376	2.01187325656248	GRHPR/GCSH/ALAS1/SHMT1/AMT/BPGM/GAMT/CTH/PHGDH	2.27228655815118
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	8/1023	35/9376	2.09490294651585	SORD/PFKP/FBP1/TPI1/ALDOA/MPI/TKFC/ALDOC	2.2709897549141
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	9/1023	42/9376	1.96397151235861	SAT1/FTH1/MAP1LC3B/MAP1LC3A/GPX4/VDAC2/SAT2/ACSL1/NCOA4	2.1910745828813
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	10/1023	50/9376	1.83304007820137	ARG2/SAT1/AMD1/CKB/SAT2/ALDH3A2/AGMAT/NOS3/GAMT/ALDH1B1	2.06683309537616
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	14/1023	78/9376	1.64503596761661	ARPC1B/CLTB/ARPC1A/RAC1/MET/CLTA/CTTN/CDC42/ARPC5L/WASF2/SEPTIN11/SEPTIN8/ACTG1/CTNNA1	2.00188293116619
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	7/1023	31/9376	2.06956137861445	ALDH3B2/ALDH3A2/MLYCD/ACADS/ACOX3/EHHADH/ALDH1B1	2.08736847802133
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	18/1023	110/9376	1.49976006398294	GAPDH/PFKP/MKNK2/RPS6KB2/RPS6/EGLN2/EPAS1/CDKN1B/ALDOA/MAPK3/LDHC/IL6R/CUL2/CAMK2B/NOS3/VEGFA/TLR4/ALDOC	1.84507471601122
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	10/1023	54/9376	1.69725933166793	AMD1/MPST/BCAT2/APIP/MTAP/MDH2/LACC1/LDHC/CTH/PHGDH	1.79820367234656
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	6/1023	27/9376	2.03671119800152	SCP2/ACOT4/ACAA1/HACD1/ACOX3/SCD	1.88781445047897
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	7/1023	34/9376	1.88695302167788	NFIL3/SKP1/PER2/PRKAG1/PRKAA2/NPAS2/DBP	1.81310250953219
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	14/1023	85/9376	1.5095624173423	GUK1/NME4/APRT/DTYMK/ENTPD8/NME3/GMPR2/NT5C/PNP/NME2/LACC1/GDA/NME6/ASMTL	1.65149717977033
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	15/1023	93/9376	1.47825812758175	MYL12B/MYL12A/ARHGAP29/TJP1/RAC1/MET/ACP1/CDC42/PDCD10/WASF2/CSNK2A1/ACTG1/MAPK3/CTNNA1/SNAI1	1.62204116820474
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	17/1023	109/9376	1.42943492336804	SLC27A4/RPS6KB2/SLC27A5/MLX/PYGB/PPP1R3B/CD36/PRKAG1/PTPA/CREB3/PRKAA2/RPS6KA2/PPP1R3D/RPS6KA6/NOS3/PPARGC1A/IRS1	1.57813169383931
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	5/1023	23/9376	1.99243486761018	FNTA/PMVK/FDPS/GGPS1/ACAT2	1.66760304435943
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	8/1023	44/9376	1.66640007109215	TAF11/TAF10/TAF9/GTF2H5/TAF13/GTF2A1/TAF6L/GTF2E1	1.55051589332458
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	19/1023	128/9376	1.36045943304008	GUK1/NME4/APRT/HDDC3/ENTPD8/NME3/PDE6A/GMPR2/NT5C/PNP/NME2/PDE4C/LACC1/PGM2/GDA/NME6/PDE3A/ADPRM/ADCY10	1.43694347258749
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	4/1023	17/9376	2.15651773906043	SCP2/SLC27A5/ACOT8/AMACR	1.67018373462778
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	4/1023	17/9376	2.15651773906043	SEPHS2/PSTK/TXNRD2/CTH	1.67018373462778
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	8/1023	46/9376	1.59394789408815	PSMC3/PSMD4/PSMB6/ADRM1/PSMB3/SEM1/PSMC5/PSMD8	1.41315127650306
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	4/1023	18/9376	2.03671119800152	MECR/HSD17B8/ACSL1/MCAT	1.5406526527341
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	19/1023	133/9376	1.30931434157241	SGK1/CCNG2/GABARAPL1/HOMER2/BNIP3/DEPP1/USP7/CDKN1B/PRKAG1/PRKAA2/CDKN2B/CDKN2D/MAPK3/TNFSF10/BCL6/CHUK/CCNB1/PLK2/IRS1	1.25724991563603
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	11/1023	70/9376	1.44024577572965	RAC1/MET/CDC42/EGLN2/EPAS1/FH/MAPK3/CUL2/PAK6/VEGFA/PDGFB	1.29379332969842
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	39/1023	300/9376	1.19147605083089	MAP2K6/DUSP2/RPS6KA5/HSPB1/MAP3K13/PLA2G4A/MKNK2/MAPK8IP1/MAP3K8/LAMTOR3/RAC1/MET/PRKACB/VEGFB/TRADD/DUSP3/CDC42/IRAK4/MAP3K4/DUSP8/ERBB3/HSPA1B/EFNA1/FGF18/RPS6KA2/MAPK3/ECSIT/FGFR2/ELK4/RPS6KA6/MAP3K21/VEGFA/CHUK/PDGFB/MAP2K7/ARTN/MAPT/FGF9/RPS6KA4	1.17958722301818
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	11/1023	71/9376	1.41996062395881	ATP6V1C2/ATP6V1G1/TJP1/ATP6V0D1/ATP6V1F/ATP6V1D/ATP6V1E1/RAC1/MET/CDC42/CHUK	1.2430304636834
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	12/1023	79/9376	1.39218233787446	ATP6V1C2/CLTB/ATP6V1G1/ATP6V0D1/ATP6V1F/ATP6V1D/ATP6V1E1/CLTA/AP2S1/STXBP1/STX3/SLC1A1	1.22498952669372
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	20/1023	144/9376	1.27294449875095	MAP2K6/LPIN2/LPIN3/TRADD/C3/ALDH3A2/FADD/IRAK4/PRKAG1/PRKAA2/MLYCD/RIPK1/CAMKK2/ACOX3/CHUK/TLR4/PPARGC1A/MAP2K7/SCD/ALDH1B1	1.15507426509124
Cellular Processes	Cell motility	hsa04814	Motor proteins	26/1023	194/9376	1.22832582559886	TUBA1C/DYNLT3/MYL6B/MYL12B/MYL12A/TUBB4B/MYL6/DYNC1I1/ACTG2/BICDL2/DYNLRB1/DCTN3/TUBA1B/CAPZA2/DCTN2/KIF22/TPM4/MYH14/TUBG1/ACTR1A/ACTG1/KIF1C/TUBB2A/KIF1B/TUBB8/KLC3	1.12457771149314
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	19/1023	137/9376	1.27108618561409	TUBA1C/SEPTIN4/TUBA1B/LMNA/PARP4/CYCS/NOL3/TRADD/CASP6/FADD/ACTG1/DAB2IP/MAPK3/CTSV/RIPK1/TNFSF10/CHUK/PARP2/BAK1	1.11855514853385
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	5/1023	27/9376	1.69725933166793	HMGCL/ACAT2/HADH/ACADS/EHHADH	1.2696845993286
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	7/1023	42/9376	1.52753339850114	ACAT2/HADH/ALDH3A2/IDO2/DHTKD1/EHHADH/ALDH1B1	1.19906553903104
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	17/1023	122/9376	1.27711808727145	PPP2R1B/PFKP/FBP1/RPS6KB2/RHEB/RAB8A/CD36/PRKAG1/CREB3/PRKAA2/MLYCD/CAMKK2/LEPR/PPARGC1A/SCD/CFTR/IRS1	1.07815761551437
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	21/1023	155/9376	1.24173682716867	TUBA1C/TUBB4B/STX18/ATP6V1C2/DYNC1I1/ATP6V1G1/TUBA1B/ATP6V0D1/ATP6V1F/ATP6V1D/ATP6V1E1/RAC1/C3/CD36/STX7/ACTG1/RILP/TUBB2A/EEA1/TUBB8/TLR4	1.06199352795387
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	12/1023	83/9376	1.32508921315762	POLR3K/POLR2L/POLR2F/POLR2K/POLR2H/FADD/POLR3H/RIPK1/POLR3F/RIPK3/CHUK/DNASE2	1.04103624742471
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	6/1023	36/9376	1.52753339850114	ST6GALNAC1/GCNT3/B3GNT3/GALNT9/GALNT1/GALNT15	1.10976235043172
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	15/1023	108/9376	1.27294449875095	EEF1A1/THOC7/PHAX/SNUPN/SUMO1/SUMO3/NCBP2/UPF1/DDX19B/NMD3/NXT2/NUP98/THOC5/NUP210L/UPF3B	0.998378971347441
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	11/1023	76/9376	1.32654216185625	SLC27A4/DBI/SCP2/SLC27A5/ACSL1/ACAA1/CD36/CPT2/ACOX3/EHHADH/SCD	1.00024594601783
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	19/1023	142/9376	1.22632962978261	MAP2K6/MGST2/GSTP1/TXN2/RAC1/SQSTM1/SUMO1/SUMO3/ACTG1/PRKAA2/GSTM4/NOS3/VEGFA/SDC4/CHUK/PDGFB/MAP2K7/SDC1/THBD	0.951027038491367
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	22/1023	168/9376	1.20020481310804	PPIA/FTH1/CHMP4C/SLC25A4/CHMP3/SLC25A6/PLA2G4A/CHMP2A/VDAC2/SHARPIN/SQSTM1/PYGB/TRADD/VDAC1/FADD/STAT6/SPATA2L/RIPK1/TNFSF10/RIPK3/CAMK2B/TLR4	0.916323266652914
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	19/1023	144/9376	1.2092972738134	SLC25A4/SLC25A6/VDAC2/WIPI2/PSMC3/WIPI1/PSMD4/PSMB6/NRBF2/CYCS/ADRM1/PSMB3/VDAC1/SEM1/PSMC5/PSMD8/KAT5/AFG3L2/ATG14	0.885725471082697
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	11/1023	78/9376	1.2925282602702	LSM3/MPHOSPH6/PFKP/LSM4/LSM2/TOB1/EXOSC1/CNOT7/EXOSC3/EXOSC9/PABPC4L	0.907867716714225
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	10/1023	70/9376	1.30931434157241	TRADD/ACSL1/CD36/PRKAG1/PRKAA2/CAMKK2/LEPR/CHUK/PPARGC1A/IRS1	0.909012315321326
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	6/1023	38/9376	1.44713690384319	GALE/GALK1/GNPDA1/PGM2/MPI/AMDHD2	0.966512762492595
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	6/1023	38/9376	1.44713690384319	QPRT/NAPRT/NT5C/PNP/SIRT7/NUDT12	0.966512762492595
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	7/1023	46/9376	1.39470440732713	FTH1/BLVRB/UGT2B7/ALAS1/UROD/HCCS/COX15	0.939100959204574
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	4/1023	23/9376	1.59394789408815	ARG2/ASL/GPT2/NOS3	0.998019465758342
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	8/1023	56/9376	1.30931434157241	EEF1G/EEF1A1/BNIP3/CYCS/C3/HSPA1B/TLR5/TLR4	0.812434445915971
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	5/1023	32/9376	1.43206256109482	GABARAPL1/WIPI2/IGBP1/WIPI1/ATG4A	0.856756532089536
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	3/1023	17/9376	1.61738830429533	CA2/CA8/CA12	0.891600594575572
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	6/1023	41/9376	1.34124883770832	BABAM1/SEM1/RAD51C/NBN/BRCC3/PALB2	0.766316474796019
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/1023	10/9376	1.83304007820137	MPST/SQOR	0.922339979340746
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	23/1023	187/9376	1.12727063632704	CASP4/MAP1LC3B/TRIP6/GABARAPL1/MAP1LC3A/TXNIP/VDAC2/TXN2/SHARPIN/RIPK2/VDAC1/FADD/IRAK4/BRCC3/CARD6/MAPK3/PKN2/RIPK1/GBP3/RIPK3/CHUK/TLR4/RNASEL	0.615201105708366
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	8/1023	59/9376	1.24273903606872	NME4/DTYMK/ENTPD8/NME3/NT5C/NME2/NME6/ASMTL	0.654530359373067
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	8/1023	60/9376	1.22202671880091	SPHK1/HSPB1/PLA2G4A/RAC1/CDC42/MAPK3/NOS3/VEGFA	0.603765565629483
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	6/1023	44/9376	1.24980005331911	GNAS/DYNC1I1/DCTN2/PRKACB/STX4/CREB3	0.581210851598266
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	4/1023	28/9376	1.30931434157241	MECR/HADH/ACOT4/HACD1	0.573616895891754
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	7/1023	54/9376	1.18808153216755	CENPX/RAD51C/CENPS/FANCF/RMI2/FAAP24/PALB2	0.485054679777785
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	5/1023	37/9376	1.2385405933793	ASRGL1/RIMKLB/ASL/GPT2/NIT2	0.508762606839448
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	5/1023	37/9376	1.2385405933793	HGD/MIF/ALDH3B2/GSTZ1/FAHD1	0.508762606839448
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	8/1023	63/9376	1.16383497028658	ACAT2/HADH/ALDH3A2/DHTKD1/SETMAR/EHMT2/EHHADH/ALDH1B1	0.456598304328596
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	12/1023	98/9376	1.12226943563349	SPHK1/ARPC1B/PLA2G4A/RPS6KB2/ARPC1A/RAC1/CDC42/ARPC5L/WASF2/LIMK2/MAPK3/CFL2	0.425800312385238
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/1023	12/9376	1.52753339850114	COQ3/COQ2	0.639899977923698
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	24/1023	205/9376	1.07299907016665	MAP2K6/PSMC3/PSMD4/RAC1/ENTPD8/CYCS/ADRM1/TRADD/SEM1/USP7/FADD/PSMC5/IRAK4/PSMD8/CDKN1B/CCNE1/SNW1/RIPK1/TAPBPL/BLNK/CHUK/BTK/MAP2K7/BAK1	0.369818068861304
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	29/1023	250/9376	1.06316324535679	CBLC/CHMP4C/RAB11FIP1/CHMP3/ARPC1B/CLTB/SNF8/CHMP2A/CAPZA2/MVB12A/SH3GLB1/ARPC1A/VPS28/CLTA/AP2S1/CDC42/RAB8A/ARPC5L/VPS36/RAB22A/HSPA1B/EEA1/ARFGAP2/FGFR2/RAB11FIP4/WASHC2C/PARD6A/RAB35/RBSN	0.354239040313722
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	5/1023	38/9376	1.20594741986932	SGK1/FXYD4/HSD11B2/MAPK3/IRS1	0.445167482252659
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	8/1023	65/9376	1.12802466350853	AKR1A1/LPIN2/MGLL/LPIN3/ALDH3A2/AGPAT5/TKFC/ALDH1B1	0.362455231384715
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	4/1023	30/9376	1.22202671880091	IDH3B/FH/MDH2/IDH3G	0.426240972636186
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	4/1023	30/9376	1.22202671880091	B3GALT4/PIGC/PIGZ/PIGA	0.426240972636186
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	5/1023	39/9376	1.17502569115472	GCSH/ALDH1L2/SHMT1/AMT/CTH	0.383294546139921
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	14/1023	119/9376	1.07825886953022	MAP2K6/RPS6KA5/MAP3K8/TRADD/FADD/CREB3/DAB2IP/MAPK3/RIPK1/RIPK3/RHBDF1/CHUK/MAP2K7/RPS6KA4	0.300658947831768
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	11/1023	93/9376	1.08405596022662	CYCS/TRAF4/CDKN1B/CCNE1/LAMA5/CKS2/CDKN2B/LAMA4/CHUK/LAMB3/BAK1	0.285080838270221
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	3/1023	22/9376	1.24980005331911	ALDH3B2/ALDH3A2/ALDH1B1	0.410494553029373
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	16/1023	138/9376	1.0626319293921	PPP2R1B/ANAPC11/YWHAB/ANAPC16/ANAPC15/PRKACB/SKP1/CCNE1/RPS6KA2/MAPK3/CDC23/CAMK2B/RPS6KA6/CCNB1/AURKA/ANAPC2	0.259387216688094
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	16/1023	138/9376	1.0626319293921	FBP1/MKNK2/RPS6KB2/RPS6/RHEB/PRKACB/TRIP10/PYGB/PPP1R3B/PRKAG1/PRKAA2/MAPK3/PPP1R3D/PPARGC1A/IRS1/PPP1R3F	0.259387216688094
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	16/1023	138/9376	1.0626319293921	MAP2K6/ARPC1B/ARPC1A/RAC1/CDC42/ARPC5L/WASF2/IRAK4/ACTG1/RPS6KA2/MAPK3/PKN2/RPS6KA6/CHUK/TLR4/MAP2K7	0.259387216688094
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	4/1023	31/9376	1.1826065020654	AKR1A1/UGT2B7/ALDH3A2/ALDH1B1	0.356376982110955
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	4/1023	31/9376	1.1826065020654	SRP9/GET3/IMMP1L/UBL4A	0.356376982110955
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	9/1023	77/9376	1.07125718855924	RALB/RPS6KB2/RALBP1/RAC1/CDC42/MAPK3/VEGFA/CHUK/BAK1	0.21971420525793
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	4/1023	32/9376	1.14565004887586	GALE/PFKP/GALK1/PGM2	0.288816116021133
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	4/1023	32/9376	1.14565004887586	SEPTIN4/CYCS/FADD/BAK1	0.288816116021133
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	5/1023	41/9376	1.11770736475693	RPS6KA5/DAPK3/MAPK3/VEGFA/DAPK1	0.264326447010965
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	24/1023	214/9376	1.0278729410475	MAP2K6/RPS6KB2/RNF7/AP1M2/RAC1/CYCS/TRADD/WEE1/FADD/SKP1/IRAK4/LIMK2/GNG7/MAPK3/RIPK1/CFL2/PAK6/TAPBPL/CHUK/CCNB1/TLR4/MAP2K7/APOBEC3C/BAK1	0.144343341068838
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	16/1023	142/9376	1.0326986356064	CBLC/UBA52/ANAPC11/UBE2H/STUB1/RNF7/ANAPC16/ANAPC15/UBE2D4/UBE2B/UBE2Q1/SKP1/CDC23/CUL2/UBOX5/ANAPC2	0.137398212568708
Organismal Systems	Digestive system	hsa04978	Mineral absorption	7/1023	61/9376	1.05174430716472	FTH1/ATOX1/SLC39A4/SLC5A1/SLC30A1/STEAP2/SLC26A3	0.141885586109446
NA	NA	hsa04382	Cornified envelope formation	24/1023	217/9376	1.01366271605606	KRT23/KRT8/KRT18/KRT19/DSP/S100A13/KRT80/S100A11/JUP/SLC27A4/PPP2R1B/TJP1/ABHD5/CLDN4/KRT10/CLDN7/CLDN1/PKP3/S100A2/LAMA5/KRT15/CLDN15/KRT6A/LAMB3	0.0712598812871276
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	12/1023	107/9376	1.0278729410475	GNAS/PFKP/FBP1/PRKACB/PPP4C/PYGB/PRKAG1/CREB3/PRKAA2/LDHC/CAMK2B/PPARGC1A	0.101475326736886
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	6/1023	52/9376	1.05752312203925	GNAS/PLA2G4A/HSD17B2/PRKACB/ACOT4/BMP6	0.14556105777113
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	10/1023	89/9376	1.02979779674234	GNAS/TUBA1C/TUBB4B/TUBA1B/TJP1/PRKACB/TUBB2A/MAPK3/TUBB8/PDGFB	0.0988424833696042
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	9/1023	80/9376	1.03108504398827	RPS6KB2/RPS6/MET/ERBB3/MAPK3/IL6R/FGFR2/VEGFA/PDGFB	0.0977126151130585
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	13/1023	117/9376	1.01835559900076	MTA1/ZNHIT1/MCRS1/INO80C/BRD8/MEAF6/MORF4L1/BRD7/ACTG1/KAT5/UCHL5/VPS72/INO80B	0.0699168195836854
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	7/1023	62/9376	1.03478068930722	CRYAB/RPS6KB2/PRKACB/PRKAG1/HSPA1B/PRKAA2/IRS1	0.0961541708402221
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	10/1023	90/9376	1.01835559900076	RPS6KB2/RHEB/PRKACB/PRKAG1/CREB3/PRKAA2/CAMKK2/EHMT2/PPARGC1A/IRS1	0.0612318936907092
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	12/1023	109/9376	1.00901288708332	MAP2K6/MAP3K8/RAC1/FADD/IRAK4/MAPK3/RIPK1/TLR5/CHUK/TLR4/MAP2K7/TLR1	0.0331214858997287
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/1023	16/9376	1.14565004887586	MIF/ALDH3B2	0.204049209210939
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	20/1023	184/9376	0.996217433805092	MYL12B/MYL12A/RAC1/MET/NCK1/CDC42/SSH3/SLIT2/LIMK2/EFNA1/RHOD/MAPK3/CFL2/CAMK2B/PAK6/SEMA3B/CDK5/PARD6A/NTN1/EPHB2	-0.018133960062937
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	12/1023	110/9376	0.999840042655292	ANAPC11/ANAPC16/ANAPC15/KIF22/PRKACB/RPS6KA2/MAPK3/CDC23/RPS6KA6/CCNB1/AURKA/ANAPC2	-0.000590549893100798
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	3/1023	26/9376	1.05752312203925	PLA2G4A/ACAA1/ACOX3	0.102784004049464
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	17/1023	158/9376	0.986129155994407	PPP2R1B/ANAPC11/YWHAB/ANAPC16/ANAPC15/WAPL/WEE1/SKP1/CDKN1B/CCNE1/CDKN2B/CDKN2D/CDC23/CDKN1C/CCNB1/CHEK2/ANAPC2	-0.0615340207337577
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	4/1023	36/9376	1.01835559900076	DCXR/AKR1A1/SORD/UGT2B7	0.0386143374970065
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	11/1023	103/9376	0.978807808748304	WDR82/PPP2R1B/SSU72/ETF1/NCBP2/UPF1/DDX19B/NXT2/CLP1/UPF3B/PABPC4L	-0.0756809476428368
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	4/1023	37/9376	0.990832474703442	GALE/GALK1/PGM2/MPI	-0.0195526220592855
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	7/1023	66/9376	0.972066708137089	UGT2B7/HSD17B8/HSD17B2/HSD11B2/DHRS11/HSD11B1L/SRD5A3	-0.0796932357731624
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	8/1023	76/9376	0.964757935895457	GNAS/CA2/PRKACB/SLC9A4/ACTG1/CAMK2B/KCNQ1/CFTR	-0.107951547663811
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	2/1023	18/9376	1.01835559900076	AGA/NEU1	0.0272781873558998
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	3/1023	28/9376	0.981985756179305	FUT2/B3GNT3/B4GALNT2	-0.0334070336659307
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	3/1023	28/9376	0.981985756179305	MOCOS/QDPR/MOCS2	-0.0334070336659307
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	18/1023	173/9376	0.95360466496025	SLC25A4/SLC25A6/TRIM25/FDPS/CYCS/TRADD/VDAC1/FADD/IRAK4/ACTG1/NXT2/MAPK3/NUP98/TNFSF10/CHUK/TLR4/RNASEL/BAK1	-0.215543469989032
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/1023	29/9376	0.948124178380018	CNGA1/PDE6A/RGS9	-0.0979106830162807
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	5/1023	49/9376	0.935224529694576	GNAS/PRKACB/CREB3/RGS9/CDK5	-0.159088886042138
Human Diseases	Infectious disease: viral	hsa05162	Measles	14/1023	136/9376	0.94347651083894	EIF3H/RACK1/RAB9A/CYCS/TRADD/FADD/IRAK4/CDKN1B/CSNK2A1/CCNE1/HSPA1B/CHUK/TLR4/BAK1	-0.232361753758695
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	6/1023	59/9376	0.932054277051543	MGST2/GPX4/GGCT/GSTP1/G6PD/GSTM4	-0.18321131689229
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	3/1023	30/9376	0.916520039100684	SHMT1/ABCC3/CHUK	-0.160262602273835
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	16/1023	157/9376	0.934033160866939	MAP2K6/SLC25A4/SLC25A6/VDAC2/RHEB/SQSTM1/VDAC1/CCNE1/HUS1/NBN/LIN37/CDKN2B/MAPK3/TRAF3IP2/CCNB1/CHEK2	-0.291699582811819
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	23/1023	224/9376	0.941069683005167	ETS2/SLC25A4/MSX1/TSPO/ANAPC11/SLC25A6/VDAC2/ANAPC16/FDPS/ANAPC15/PRKACB/VDAC1/CCNE1/CREB3/KAT5/CDKN2B/TLN1/MAPK3/CDC23/ELK4/CHUK/CHEK2/ANAPC2	-0.312397100997863
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	21/1023	205/9376	0.938874186395823	YWHAB/ATP6V0D1/RAC1/MRPS18B/PRKACB/TRADD/C3/CDC42/USP7/GTF2A1/CDKN1B/CCNE1/HDAC5/CREB3/SNW1/CDKN2B/MAPK3/GTF2E1/HDAC11/HDAC10/BAK1	-0.309667373749628
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/1023	20/9376	0.916520039100684	TM7SF2/CYP2R1	-0.130783917656496
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/1023	20/9376	0.916520039100684	CYB5R2/CYB5RL	-0.130783917656496
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	12/1023	120/9376	0.916520039100684	RPS6KA5/RIPK2/RAC1/CDC42/IRAK4/RPS6KA2/MAPK3/CAMK2B/RPS6KA6/MAP2K7/PSEN2/IRS1	-0.322079735863906
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	14/1023	140/9376	0.916520039100684	SPHK1/MAP1LC3B/MAP1LC3A/RPS6KB2/RPS6/PRKACB/PRKAG1/HDAC5/GNG7/PRKAA2/MAPK3/NOS3/PPARGC1A/ADCY10	-0.348262334623908
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	15/1023	150/9376	0.916520039100684	JUP/RPS6KB2/FRAT2/MET/CDKN1B/CCNE1/FGF18/CDKN2B/MAPK3/CTNNA1/WNT2B/FGFR2/BAK1/FGF9/FRAT1	-0.360681075260725
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	6/1023	62/9376	0.886954876549049	TLE6/SNW1/TLE2/NOTCH2/HES5/PSEN2	-0.312522849013777
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	7/1023	72/9376	0.891061149125665	TRIM25/SIKE1/TRADD/FADD/RIPK1/TKFC/CHUK	-0.324725505528644
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	8/1023	82/9376	0.894165891805546	MGST2/UGT2B7/NME4/GSTP1/NME3/NME2/GSTM4/NME6	-0.336847602842587
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	9/1023	93/9376	0.886954876549049	GNAS/MAP2K6/PLA2G4A/PRKACB/CDC42/MAP3K4/MAPK3/CAMK2B/MAP2K7	-0.38339932669704
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	5/1023	53/9376	0.8646415463214	GNAS/CLTB/CLTA/PRKACB/AP2S1	-0.345818076966617
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	23/1023	232/9376	0.908619004280851	RGCC/MYL12B/MYL12A/ARPC1B/TMSB4X/ARPC1A/RAC1/RDX/CDC42/ARPC5L/WASF2/SSH3/MYH14/LIMK2/ACTG1/FGF18/MAPK3/CFL2/FGFR2/PIP4K2C/PAK6/PDGFB/FGF9	-0.49321239691807
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	9/1023	95/9376	0.868282142305911	ATP6V1C2/ATP6V1G1/ATP6V0D1/ATP6V1F/ATP6V1D/ATP6V1E1/VEGFA/TLR4/TNFRSF11A	-0.451555658909283
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	10/1023	105/9376	0.872876227714937	TRIM25/TRADD/IRAK4/CSNK2A1/RIPK1/BLNK/CHUK/TLR4/BTK/TNFRSF11A	-0.458416609816481
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	7/1023	75/9376	0.855418703160639	MGST2/GSTP1/CYCS/FADD/MAPK3/GSTM4/BAK1	-0.439926516450098
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	2/1023	23/9376	0.796973947044073	RFC1/RFC5	-0.341147691443835
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/1023	23/9376	0.796973947044073	ACE/NLN	-0.341147691443835
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	11/1023	116/9376	0.869113830181683	MYL12B/MYL12A/RAC1/CLDN4/CDC42/CLDN7/CLDN1/ACTG1/ARHGAP5/CTNNA1/CLDN15	-0.496385943240869
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	8/1023	86/9376	0.852576780558776	RPS6KB2/NCK1/CDKN1B/ERBB3/MAPK3/CAMK2B/PAK6/MAP2K7	-0.480628449490476
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	8/1023	86/9376	0.852576780558776	DSP/JUP/LMNA/DSC2/ACTG1/SGCD/CTNNA1/DTNA	-0.480628449490476
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	9/1023	97/9376	0.850379417722284	GNAS/RPS6KA5/PRKACB/PER2/GNG7/MAPK3/NOS1AP/CAMK2B/ADCY10	-0.518356841213034
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	5/1023	56/9376	0.818321463482754	DPM3/MGAT4B/TMEM258/DPM1/SRD5A3	-0.477190615863061
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	23/1023	238/9376	0.885712642828392	ETS2/RALB/PLA2G4A/RALBP1/RAC1/MET/PRKACB/VEGFB/CDC42/GNG7/EFNA1/FGF18/MAPK3/KSR1/RALGAPA2/RASAL1/FGFR2/KSR2/PAK6/VEGFA/CHUK/PDGFB/FGF9	-0.624975950972541
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	9/1023	99/9376	0.833200035546077	PLA2G4A/RPS6KB2/RHEB/SLC44A1/RAC1/WASF2/CHKB/MAPK3/PDGFB	-0.58386438831673
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	3/1023	36/9376	0.76376669925057	RNASEH2C/RFC1/RFC5	-0.496959668970348
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7/1023	79/9376	0.8121063637601	ALDH3B2/MGST2/UGT2B7/GSTP1/AKR7A2/HSD11B1L/GSTM4	-0.5868896028662
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	10/1023	110/9376	0.833200035546077	ID1/ID3/PPP2R1B/RPS6KB2/ID2/SMAD9/SKP1/CDKN2B/MAPK3/BMP6	-0.615812305194541
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	6/1023	69/9376	0.796973947044073	MAP2K6/PLA2G4A/RAC1/MAPK3/BTK/MAP2K7	-0.59234356433791
NA	NA	hsa04517	IgSF CAM signaling	29/1023	299/9376	0.888932479395313	TUBA1C/MYL6B/MYL12B/MYL12A/TUBB4B/MYL6/ARPC1B/TUBA1B/TJP1/ARPC1A/RAC1/RDX/NCK1/CDC42/ARPC5L/MYH14/SLIT2/ACTG1/ICAM3/TUBB2A/MAPK3/PAK6/CABLES1/PARD6A/TUBB8/GRIP1/NTN1/PVR/RAPGEF6	-0.683051922261356
Organismal Systems	Digestive system	hsa04976	Bile secretion	8/1023	90/9376	0.814684479200608	GNAS/CA2/UGT2B7/SLC27A5/PRKACB/SLC5A1/ABCC3/CFTR	-0.61818850304786
NA	NA	hsa03272	Virion - Hepatitis viruses	4/1023	48/9376	0.76376669925057	CLDN4/CLDN7/CLDN1/CLDN15	-0.574208586482235
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	3/1023	37/9376	0.743124356027582	NCOA4/MAPK3/BAK1	-0.547867850958019
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	5/1023	59/9376	0.776711897542953	GNAS/MGLL/ABHD5/PRKACB/IRS1	-0.602082155024969
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	6/1023	70/9376	0.785588604943444	MGST2/UGT2B7/GSTP1/HSD11B1L/GSTM4/CYP2C18	-0.630111742187071
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	6/1023	70/9376	0.785588604943444	RAC1/CYCS/ACTG1/SGCD/CD55/DTNA	-0.630111742187071
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/1023	26/9376	0.705015414692834	AMN/SLC52A3	-0.527087121419672
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	10/1023	112/9376	0.818321463482754	MAP2K6/CYCS/IRAK4/HSPA1B/LAMA5/MAPK3/LAMA4/CHUK/TLR4/LAMB3	-0.676886068005806
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	9/1023	102/9376	0.808694152147663	GNAS/CA2/RAC1/RAB8A/RAB3D/KCNQ1/SLC26A3/CPB2/CFTR	-0.679824794739343
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	3/1023	38/9376	0.723568451921593	RFXANK/BLNK/BTK	-0.597523078227213
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	6/1023	71/9376	0.774523976704804	PFKP/MET/G6PD/MAPK3/LDHC/FGFR2	-0.667380582360525
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/1023	14/9376	0.654657170786203	CHST1	-0.452514350473816
NA	NA	hsa04518	Integrin signaling	14/1023	154/9376	0.833200035546077	RAC1/MET/VEGFB/C3/CDC42/ACTG1/ICAM3/LAMA5/FLNB/TLN1/LAMA4/VEGFA/LAMB3/PDGFB	-0.730375118163512
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	9/1023	103/9376	0.800842752612248	GNAS/PPP2R1B/ACE/C3/FADD/IRAK4/MAPK3/CHUK/TLR4	-0.711224669182684
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	9/1023	103/9376	0.800842752612248	GNAS/ARG2/HSPB1/SERPINB9/PRKACB/LAMA5/LAMA4/TLR4/LAMB3	-0.711224669182684
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	4/1023	50/9376	0.733216031280547	MET/CD36/TLR4/SDC1	-0.66191045340303
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	14/1023	156/9376	0.822517983808306	PPP2R1B/YWHAB/CYCS/TRADD/CLDN4/CLDN7/FADD/CLDN1/MAPK3/RIPK1/CLDN15/CHUK/RNASEL/BAK1	-0.782264112206931
Human Diseases	Cancer: specific types	hsa05218	Melanoma	6/1023	73/9376	0.75330414172659	MET/FGF18/MAPK3/PDGFB/BAK1/FGF9	-0.740481124065379
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/1023	15/9376	0.611013359400456	B3GALT4	-0.527620191710221
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/1023	15/9376	0.611013359400456	ACP1	-0.527620191710221
Organismal Systems	Immune system	hsa04611	Platelet activation	11/1023	126/9376	0.800136542072026	GNAS/MYL12B/MYL12A/PLA2G4A/VAMP8/PRKACB/ACTG1/TLN1/MAPK3/NOS3/BTK	-0.790405616476742
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	9/1023	106/9376	0.77817739168926	GSTP1/SPINT1/CDKN1B/CCNE1/CREB3/MAPK3/FGFR2/CHUK/PDGFB	-0.803750188101976
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	4/1023	52/9376	0.705015414692834	TSPO/VDAC2/VDAC1/CD36	-0.746452326321755
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/1023	29/9376	0.632082785586679	SAV1/RASSF6	-0.694408775258417
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	6/1023	75/9376	0.733216031280547	CCNG2/PERP/CYCS/CCNE1/CCNB1/CHEK2	-0.81176019699063
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/1023	16/9376	0.572825024437928	FUT2	-0.598453049833424
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	19/1023	212/9376	0.82140946900533	GNAS/ID1/MAP2K6/RALB/RAC1/MET/VEGFB/CDC42/ACTG1/EFNA1/FGF18/TLN1/MAPK3/FGFR2/PARD6A/VEGFA/PDGFB/FGF9/RAPGEF6	-0.920419970591226
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	31/1023	333/9376	0.853216853216853	GNAS/ATP6V1C2/PPP2R1B/ATP6V1G1/RPS6KB2/ATP6V0D1/RHEB/ATP6V1F/ATP6V1D/ATP6V1E1/PRKACB/TRADD/CDC42/TADA3/FADD/TUBG1/CDKN1B/CCNE1/CREB3/LAMA5/MAPK3/HES2/WNT2B/LAMA4/PARD6A/VEGFA/CHUK/LAMB3/NOTCH2/HES5/BAK1	-0.954430390979091
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	8/1023	99/9376	0.740622253818735	ACE/LMNA/TPM4/PRKAG1/ACTG1/SGCD/PRKAA2/DTNA	-0.907922430396743
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/1023	17/9376	0.539129434765108	MYH14	-0.665565685528845
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	3/1023	43/9376	0.639432585419082	SLC27A4/ACAT2/CD36	-0.829301183299511
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	4/1023	55/9376	0.666560028436861	SPHK1/CERK/NEU1/ACER2	-0.867900553541827
NA	NA	hsa04981	Folate transport and metabolism	2/1023	31/9376	0.5913032510327	SHMT1/ABCC3	-0.797617348495958
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	5/1023	67/9376	0.683970178433346	PRKACB/RPS6KA2/MAPK3/CAMK2B/RPS6KA6	-0.908481664382599
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	3/1023	44/9376	0.624900026659557	MGAT4B/TMEM258/B4GALNT3	-0.872746710991207
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	17/1023	196/9376	0.794940850240389	MAP2K6/UBA52/MAP1LC3B/MAP1LC3A/RAC1/CYCS/TRADD/C3/FADD/GNG7/MAPK3/ATG14/VEGFA/CHUK/PDGFB/MAP2K7/BAK1	-1.01528521475144
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	8/1023	101/9376	0.725956466614403	RAC1/VEGFB/CDC42/CDKN1B/MAPK3/NOS3/VEGFA/THBD	-0.969003845529061
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/1023	18/9376	0.50917779950038	MMUT	-0.729409045333201
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	5/1023	68/9376	0.673911793456385	UGT2B7/DHRS4L2/RDH13/RDH10/CYP2C18	-0.944416520695279
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	5/1023	68/9376	0.673911793456385	JUP/RPS6KB2/PER2/MAPK3/CHUK	-0.944416520695279
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	3/1023	45/9376	0.611013359400456	DEFB1/ABCC3/CFTR	-0.91533287907407
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	13/1023	157/9376	0.758901943204388	SGK1/SPHK1/ARG2/DUSP2/UQCRFS1/RAC1/CD24/CD36/DUSP8/MAPK3/VPS41/CAMK2B/RAB17	-1.06611448279585
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	33/1023	362/9376	0.835501693102834	SGK1/PPP2R1B/YWHAB/RPS6KB2/RPS6/RHEB/PKN3/RAC1/MET/VEGFB/CDKN1B/CCNE1/ERBB3/GNG7/CREB3/EFNA1/LAMA5/PRKAA2/FGF18/MAPK3/PKN2/IL6R/FGFR2/LAMA4/NOS3/VEGFA/CHUK/TLR4/LAMB3/PDGFB/ARTN/FGF9/IRS1	-1.11701538562997
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/1023	19/9376	0.482378967947729	HYAL3	-0.790355744913123
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	9/1023	115/9376	0.717276552339666	SGK1/GNAS/PRKACB/NACA/CREB3/PDE4C/MAPK3/WNK3/SLC12A3	-1.06753966542727
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	15/1023	181/9376	0.759546993729849	SPHK1/ATP6V0D1/RFXANK/RIPK2/CYCS/TRADD/C3/FADD/IRAK4/MAPK3/EEA1/KSR1/CAMK2B/TLR4/TLR1	-1.14313058911113
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	6/1023	83/9376	0.662544606578808	UBE2D4/USP7/USP16/SKP1/BAP1/CBX8	-1.0806365828881
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	11/1023	139/9376	0.72530362806529	GNAS/KRT23/KRT18/KRT19/PRKACB/KRT10/CREB3/HSPA1B/MAPK3/KRT15/NOS3	-1.14181847606895
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	17/1023	203/9376	0.767529096783824	MYL12B/MYL12A/RAC1/MET/VEGFB/CDC42/ACTG1/ARHGAP5/LAMA5/FLNB/TLN1/MAPK3/PAK6/LAMA4/VEGFA/LAMB3/PDGFB	-1.1718260264487
Organismal Systems	Nervous system	hsa04730	Long-term depression	4/1023	60/9376	0.611013359400456	GNAS/PPP2R1B/PLA2G4A/MAPK3	-1.05778592933442
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	17/1023	204/9376	0.76376669925057	RPS6KB2/RPS6/RAC1/MET/RDX/PRKACB/CTTN/CDC42/ERBB3/ACTG1/MAPK3/WNT2B/CAMK2B/VEGFA/SDC4/TLR4/SDC1	-1.19378575737396
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	15/1023	183/9376	0.751245933689085	NHP2/EIF6/SBDS/RPP25L/POP7/IMP3/SNU13/POP5/POP4/RPP30/CSNK2A1/NMD3/NXT2/GTPBP4/FCF1	-1.18923947884366
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/1023	21/9376	0.436438113857469	B3GALT6	-0.904756224788051
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5/1023	73/9376	0.627753451438825	ALDH3B2/MGST2/UGT2B7/GSTP1/GSTM4	-1.11733348357452
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	5/1023	73/9376	0.627753451438825	PPIA/SUPT4H1/BICD1/MAP1S/APOBEC3C	-1.11733348357452
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	10/1023	130/9376	0.705015414692834	GNAS/PRKACB/VEGFB/GNG7/CREB3/MAPK3/NOS3/VEGFA/EDNRB/MAP2K7	-1.18521262250646
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	18/1023	216/9376	0.76376669925057	MAP2K6/HSPA2/RAC1/CYCS/CASP6/CDC42/CD36/IRAK4/POU2F3/HSPA4/HSPA1B/MAPK3/TNFSF10/CAMK2B/NOS3/CHUK/TLR4/MAP2K7	-1.2291997725807
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	3/1023	49/9376	0.561134717816746	GALNT9/GALNT1/GALNT15	-1.0778553754361
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/1023	36/9376	0.50917779950038	PYGB/PGM2	-1.0325336754377
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	12/1023	154/9376	0.714171459039494	GNAS/MYL6B/MYL6/PLA2G4A/PRKACB/PRKAG1/ACTG1/PRKAA2/MAPK3/CAMKK2/CAMK2B/NOS3	-1.251571336133
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	5/1023	75/9376	0.611013359400456	GNAS/PRKACB/CREB3/TTF1/IYD	-1.18359387753116
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	2/1023	37/9376	0.495416237351721	IDO2/LAMA4	-1.07618307985675
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	4/1023	63/9376	0.581917485143292	PTGR1/HPGD/GPX4/PLA2G4A	-1.16517106829567
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	6/1023	87/9376	0.632082785586679	RALB/RPS6KB2/RAC1/CYCS/MAPK3/BAK1	-1.20650039285298
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	12/1023	155/9376	0.709563901239239	GNAS/AHR/PRKACB/FH/CDKN1B/CCNE1/CREB3/CDKN2B/MAPK3/WNT2B/ASH2L/CAMK2B	-1.27593822083586
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	7/1023	99/9376	0.648044472091393	GNAS/MAP2K6/PLA2G4A/PRKACB/TRPM8/CAMK2B/HRH1	-1.23198047247676
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	7/1023	99/9376	0.648044472091393	KRT23/DEFB1/KRT18/KRT19/C3/KRT10/KRT15	-1.23198047247676
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/1023	51/9376	0.539129434765108	PLA2G4A/PAFAH1B1/GDPD3	-1.15489327852492
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/1023	23/9376	0.398486973522037	CA2	-1.01073127004492
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	6/1023	89/9376	0.617878678045405	CD36/LAMA5/LAMA4/SDC4/LAMB3/SDC1	-1.26753735308216
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	21/1023	254/9376	0.757752788232849	GNAS/SPHK1/SLC25A4/SLC25A6/VDAC2/TFEB/ORAI2/MET/PRKACB/VEGFB/VDAC1/ERBB3/FGF18/FGFR2/CAMK2B/NOS3/VEGFA/PDGFB/EDNRB/HRH1/FGF9	-1.36972324417244
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	19/1023	233/9376	0.747376855919013	DSP/ACTG2/JUP/LMNA/CAPZA2/PDLIM1/MYOM1/DSC2/TPM4/MYH14/OBSCN/TMOD3/PDLIM5/ACTG1/SGCD/TLN1/DTNA/SDC4/SDC1	-1.36649784436035
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	7/1023	101/9376	0.635211908287603	GNAS/PRKACB/CREB3/MAPK3/WNT2B/CAMK2B/EDNRB	-1.28987193861331
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	6/1023	90/9376	0.611013359400456	MAP2K6/RPS6KB2/CSNK2A1/MAPK3/CHUK/TLR4	-1.29760889978643
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/1023	24/9376	0.381883349625285	B3GALT6	-1.06102600574554
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	5/1023	78/9376	0.587512845577362	TPI1/INPP5J/FIG4/PIP4K2C/MTMR7	-1.2801627121897
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	5/1023	78/9376	0.587512845577362	C3/IRAK4/MAPK3/CFL2/TLR4	-1.2801627121897
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	5/1023	78/9376	0.587512845577362	EEF1A1/C3/IRAK4/MAPK3/TLR4	-1.2801627121897
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	13/1023	170/9376	0.700868265194641	MGST2/RPS6KB2/GSTP1/FRAT2/MET/BRD7/ACTG1/MAPK3/WNT2B/GSTM4/TXNRD2/BAK1/FRAT1	-1.37737970448861
Human Diseases	Substance dependence	hsa05032	Morphine addiction	6/1023	91/9376	0.604298926879572	GNAS/PRKACB/GABRE/GNG7/PDE4C/PDE3A	-1.3273919652889
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	18/1023	227/9376	0.726755978141512	GNAS/MAP2K6/RPS6KB2/RHEB/RAC1/CYCS/PRKACB/TRADD/FADD/GNG7/CREB3/MAPK3/RIPK1/IL6R/TAPBPL/VEGFA/CHUK/BAK1	-1.45840786655999
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	17/1023	217/9376	0.718011090539706	GNAS/AHR/KLF5/MGST2/RPS6KB2/UGT2B7/PRKACB/CREB3/FGF18/RPS6KA2/MAPK3/GSTM4/BCL6/RPS6KA6/VEGFA/NOTCH2/FGF9	-1.47075414068344
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	7/1023	105/9376	0.611013359400456	GNAS/LMNA/PRKACB/TPM4/ACTG1/SGCD/DTNA	-1.40271118330004
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/1023	26/9376	0.352507707346417	HNF1B	-1.15695824688881
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	12/1023	163/9376	0.674738679092528	MAP2K6/YWHAB/CYCS/FADD/IRAK4/CCNE1/CREB3/STAT6/MAPK3/CHUK/TLR4/MAP2K7	-1.46597951718135
Organismal Systems	Endocrine system	hsa04924	Renin secretion	4/1023	69/9376	0.531315964696049	GNAS/ACE/PRKACB/PDE3A	-1.36742042697586
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	4/1023	69/9376	0.531315964696049	GNAS/PRKACB/CREB3/CAMK2B	-1.36742042697586
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	6/1023	94/9376	0.58501279091533	TRAF4/TRADD/FADD/MAPK3/TRAF3IP2/CHUK	-1.41507699287745
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	5/1023	82/9376	0.558853682378466	RFXANK/HSPA2/HSPA4/HSPA1B/TAPBPL	-1.40407551146573
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	10/1023	142/9376	0.645436647254003	MAP2K6/RAC1/SQSTM1/MAPK3/BLNK/CHUK/TNFRSF11B/BTK/TNFRSF11A/MAP2K7	-1.48985943927661
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	3/1023	59/9376	0.466027138525772	MAPK3/CTNNA1/BAK1	-1.43982383129033
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	8/1023	122/9376	0.600996746951268	PPP2R1B/MAP3K8/NCK1/CDC42/MAPK3/PAK6/CHUK/MAP2K7	-1.55236491462976
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	11/1023	157/9376	0.642147798096021	ID1/PPP2R1B/SAV1/YWHAB/ID2/ACTG1/RASSF6/CTNNA1/WNT2B/BMP6/PARD6A	-1.58239108278521
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	9/1023	134/9376	0.615573160590012	GNAS/MYL6B/MYL6/ACTG2/PLA2G4A/PRKACB/MYH14/ADM/MAPK3	-1.56850292348526
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	13/1023	180/9376	0.661931139350494	RHEB/CYCS/TRADD/C3/SRSF8/FADD/IRAK4/EIF2B5/POU2F3/TAPBPL/CHUK/RNASEL/BAK1	-1.60267017721409
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	5/1023	86/9376	0.532860487849235	GNAS/PRKACB/TRPM4/CREB3/CAMK2B	-1.52296592268
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	6/1023	99/9376	0.555466690364051	GNAS/RPS6KB2/PRKACB/CDKN1B/MAPK3/NOTCH2	-1.55603851455677
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	10/1023	148/9376	0.619270296689652	RPS6KB2/FRAT2/FGF18/MAPK3/WNT2B/NOTCH2/HES5/BAK1/FGF9/FRAT1	-1.63378927016692
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/1023	30/9376	0.305506679700228	PLA2G4A	-1.33326975209388
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	5/1023	88/9376	0.520750022216298	C3/CD55/KLKB1/THBD/CPB2	-1.58068214807559
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	2/1023	47/9376	0.390008527276887	MAPK3/IRS1	-1.46709203979128
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	5/1023	89/9376	0.514898898371171	GABARAPL1/HAP1/PRKACB/GABRE/GNG7	-1.6091323121951
Human Diseases	Cancer: specific types	hsa05214	Glioma	4/1023	76/9376	0.482378967947729	MAPK3/CAMK2B/PDGFB/BAK1	-1.58554820590599
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	12/1023	174/9376	0.632082785586679	ERP29/CRYAB/SVIP/STUB1/RAD23A/UBE2D4/SKP1/RNF5/TMEM258/HSPA1B/MAP2K7/BAK1	-1.71429608159703
NA	NA	hsa04519	Cadherin signaling	33/1023	404/9376	0.748642606196103	KRT23/KRT8/KRT18/KRT19/LIMA1/DSP/KRT80/JUP/ARPC1B/SAV1/YWHAB/TJP1/ARPC1A/RAC1/MET/DSC2/CDC42/KRT10/ARPC5L/GABRE/PKP3/ACTG1/MAPK3/PCDH10/CTNNA1/KRT15/WNT2B/TMC1/KRT6A/CHUK/AMOTL2/CDH26/PSEN2	-1.8073402859056
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	4/1023	77/9376	0.476114306026329	CDKN1B/MAPK3/CHUK/BAK1	-1.61534760526973
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	7/1023	116/9376	0.553072437388344	GNAS/HOMER2/PLA2G4A/PRKACB/GNG7/MAPK3/SLC1A1	-1.69497327361079
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	5/1023	91/9376	0.50358243906631	RAC1/MAPK3/BLNK/CHUK/BTK	-1.66524866009436
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	6/1023	104/9376	0.528761561019626	LPIN2/PLA2G4A/LPIN3/CHKB/AGPAT5/ADPRM	-1.69111398565112
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	11/1023	166/9376	0.607332556030574	SLC25A4/SLC25A6/VDAC2/CNGA1/VDAC1/CREB3/MAPK3/NOS3/EDNRB/PDE3A/IRS1	-1.78628741592882
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	3/1023	65/9376	0.4230092488157	GNAS/PRKACB/CREB3	-1.63353927669886
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	3/1023	66/9376	0.416600017773038	STAT6/TLR5/TLR4	-1.66443083621679
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	9/1023	144/9376	0.572825024437928	ID1/ID3/DLX5/ID2/SMAD9/REST/MAPK3/WNT2B/FGFR2	-1.80776246900272
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	7/1023	122/9376	0.52587215358236	PFKP/RHEB/PRKACB/THRB/ACTG1/MAPK3/NOTCH2	-1.84464519575688
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	7/1023	122/9376	0.52587215358236	GNAS/MAP2K6/PRKACB/CREB3/MAPK3/ADCY10/IRS1	-1.84464519575688
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	13/1023	195/9376	0.611013359400456	CASP4/SLC25A4/SLC25A6/VDAC2/RAC1/C3/VDAC1/ACTG1/HDAC5/MAPK3/HDAC11/HDAC10/TLR4	-1.92091970878727
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	5/1023	98/9376	0.467612264847288	GNAS/PRKACB/CREB3/CAMK2B/DAGLB	-1.85402723717162
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	7/1023	125/9376	0.513251221896383	SPHK1/PPP2R1B/RAC1/TRADD/MAPK3/NOS3/ACER2	-1.91720145693872
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	5/1023	100/9376	0.458260019550342	CD24/CD36/CD55/CSF2RA/IL6R	-1.90595539262902
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	3/1023	73/9376	0.376652070863295	MET/MAPK3/BAK1	-1.87103820259282
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	6/1023	115/9376	0.478184368226444	PRKACB/GNG7/CREB3/MAPK3/CAMK2B/KCNQ1	-1.97033139475405
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	6/1023	115/9376	0.478184368226444	GNAS/PLA2G4A/PRKACB/GNG7/MAPK3/CYP2C18	-1.97033139475405
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	9/1023	154/9376	0.535628594279621	GNAS/RPS6KA5/PPP2R1B/PRKACB/TPM4/CREB3/MAPK3/CAMK2B/KCNQ1	-2.03336566308723
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	5/1023	103/9376	0.444912640340138	SLC15A1/SLC1A1/KCNQ1/CPB2/KCNK5	-1.98231211226238
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/1023	41/9376	0.223541472951386	GABRE	-1.74363366412925
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	4/1023	93/9376	0.394202167355133	STAT6/MAPK3/CHUK/NOTCH2	-2.05459973911519
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	1/1023	44/9376	0.208300008886519	ICA1	-1.84205175271752
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/1023	63/9376	0.290958742571646	WNT2B/BAK1	-1.97605575460781
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	8/1023	149/9376	0.492091296161441	GNAS/SPHK1/RALB/PLA2G4A/RHEB/MAPK3/AGPAT5/PDGFB	-2.18700987235481
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	5/1023	109/9376	0.420422036284718	AHR/STAT6/MAPK3/IL6R/CHUK	-2.12989280521568
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	12/1023	201/9376	0.547176142746677	JUP/HPGD/KLF3/ID2/SPINT1/MET/ASPSCR1/PER2/CDKN1B/BCL6/ELK4/BAK1	-2.27104900930168
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	10/1023	178/9376	0.514898898371171	FRAT2/RAC1/PRKACB/SKP1/CSNK2A1/TLE6/WNT2B/TLE2/CAMK2B/FRAT1	-2.28663988136235
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/1023	48/9376	0.190941674812643	SLC5A1	-1.96656540722123
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	4/1023	100/9376	0.366608015640274	CXCL14/CCL28/TNFSF10/IL6R	-2.22840645291934
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/1023	50/9376	0.183304007820137	CCL28	-2.02628222779262
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	2/1023	71/9376	0.258174658901601	MAPK3/TNFRSF11A	-2.19570941919567
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	8/1023	160/9376	0.458260019550342	CLDN4/CLDN7/CLDN1/ICAM3/CLDN15/SDC4/SDC1/PVR	-2.41869919673978
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	6/1023	133/9376	0.413467686812339	GNAS/PPP2R1B/PRKACB/GNG7/CREB3/CAMK2B	-2.38403980081982
Organismal Systems	Digestive system	hsa04970	Salivary secretion	3/1023	93/9376	0.29565162551635	GNAS/PRKACB/CST1	-2.38883982159882
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	1/1023	56/9376	0.163664292696551	PRKACB	-2.1966906982351
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	3/1023	98/9376	0.280567358908373	PIP4P1/PIP4K2C/MTMR7	-2.505406537045
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	12/1023	226/9376	0.486647808372045	GNAS/RAC1/PRKACB/CNGA1/CREB3/PDE4C/MAPK3/ACOX3/CAMK2B/PDE3A/ADCY10/CFTR	-2.73376580803683
Human Diseases	Substance dependence	hsa05034	Alcoholism	9/1023	191/9376	0.431868081251631	GNAS/PRKACB/HDAC5/GNG7/CREB3/MAPK3/CAMKK2/HDAC11/HDAC10	-2.77605781819102
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/1023	86/9376	0.213144195139694	PRKACB/KCNK5	-2.56530339586952
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	1/1023	65/9376	0.141003082938567	MAPK3	-2.43193707993228
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	3/1023	105/9376	0.261862868314481	MAPK3/KSR1/CHUK	-2.66177061461145
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	8/1023	193/9376	0.379904679419973	RAC1/PRKACB/CDC42/CXCL14/GNG7/CCL28/MAPK3/CHUK	-3.04612015884778
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	6/1023	168/9376	0.327328585393102	CLCF1/STAT6/CSF2RA/IL6R/LEPR/PDGFB	-3.07876947835416
NA	NA	hsa04082	Neuroactive ligand signaling	7/1023	199/9376	0.322393983603256	GNAS/PRKACB/GABRE/GNG7/SLC1A1/HRH1/TAC4	-3.38108150519513
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	3/1023	133/9376	0.206733843406169	RAC1/MAPK3/TNFSF10	-3.22433742769425
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	3/1023	143/9376	0.192276931279864	SNRPD1/C3/SNRPD3	-3.40613064671703
NA	NA	hsa04081	Hormone signaling	7/1023	219/9376	0.292951610671452	GNAS/SMAD9/PRKACB/THRB/GNG7/LEPR/IRS1	-3.70507327960855
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	14/1023	323/9376	0.397253267721659	RPS6KA5/MET/RDX/CDKN1B/CCNE1/ERBB3/HDAC5/EFNA1/MAPK3/VEGFA/PDGFB/NOTCH2/BAK1/IRS1	-3.85782106284435
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	11/1023	298/9376	0.338312766110991	CLCF1/CXCL14/CCL28/TNFSF12/CSF2RA/TNFSF10/IL6R/LEPR/BMP6/TNFRSF11B/TNFRSF11A	-4.06226277340813
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	14/1023	370/9376	0.346791366146205	GAL/TSPO/CHRNB1/C3/THRB/GABRE/ADM/GALP/LEPR/PYY/NMU/EDNRB/HRH1/TAC4	-4.4863073334414
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	4/1023	449/9376	0.0816498921247826	PRKACB/GNG7/CAMK2B/NCALD	-6.97880235278939