category subcategory ID Description GeneRatio BgRatio FoldEnrichment geneName zScore Organismal Systems Immune system hsa04612 Antigen processing and presentation 3/12 82/9376 28.5853658536585 HSPA1B/HSPA1A/HSP90AB1 8.98110758889829 Organismal Systems Endocrine system hsa04915 Estrogen signaling pathway 3/12 139/9376 16.863309352518 HSPA1B/HSPA1A/HSP90AB1 6.74498954099177 Genetic Information Processing Folding, sorting and degradation hsa04141 Protein processing in endoplasmic reticulum 3/12 174/9376 13.4712643678161 HSPA1B/HSPA1A/HSP90AB1 5.94414717622486 Human Diseases Infectious disease: bacterial hsa05134 Legionellosis 2/12 56/9376 27.9047619047619 HSPA1B/HSPA1A 7.2287094502121 Human Diseases Cardiovascular disease hsa05417 Lipid and atherosclerosis 3/12 216/9376 10.8518518518519 HSPA1B/HSPA1A/HSP90AB1 5.24375714492829 Organismal Systems Aging hsa04213 Longevity regulating pathway - multiple species 2/12 62/9376 25.2043010752688 HSPA1B/HSPA1A 6.8448799108152 Human Diseases Neurodegenerative disease hsa05020 Prion disease 3/12 275/9376 8.52363636363637 HSPA1B/MT-ATP8/HSPA1A 4.53309838834942 Human Diseases Infectious disease: parasitic hsa05145 Toxoplasmosis 2/12 112/9376 13.952380952381 HSPA1B/HSPA1A 4.93633819530015 Human Diseases Infectious disease: viral hsa05162 Measles 2/12 136/9376 11.4901960784314 HSPA1B/HSPA1A 4.41125976970503 Metabolism Metabolism of cofactors and vitamins hsa00770 Pantothenate and CoA biosynthesis 1/12 21/9376 37.2063492063492 ENPP3 5.94590609456741 Genetic Information Processing Transcription hsa03040 Spliceosome 2/12 243/9376 6.43072702331962 HSPA1B/HSPA1A 3.07043522738799 Cellular Processes Transport and catabolism hsa04144 Endocytosis 2/12 250/9376 6.25066666666667 HSPA1B/HSPA1A 3.01224144233889 Metabolism Carbohydrate metabolism hsa00500 Starch and sucrose metabolism 1/12 36/9376 21.7037037037037 ENPP3 4.45524318661016 Metabolism Amino acid metabolism hsa00250 Alanine, aspartate and glutamate metabolism 1/12 37/9376 21.1171171171171 ASRGL1 4.38896358284881 Metabolism Metabolism of cofactors and vitamins hsa00760 Nicotinate and nicotinamide metabolism 1/12 38/9376 20.5614035087719 ENPP3 4.32524222313756 Human Diseases Substance dependence hsa05033 Nicotine addiction 1/12 41/9376 19.0569105691057 GABRP 4.14785697746324 Environmental Information Processing Signal transduction hsa04010 MAPK signaling pathway 2/12 300/9376 5.20888888888889 HSPA1B/HSPA1A 2.6523229511675 Environmental Information Processing Membrane transport hsa02010 ABC transporters 1/12 45/9376 17.362962962963 DEFB1 3.93867066322105 Metabolism Nucleotide metabolism hsa00240 Pyrimidine metabolism 1/12 59/9376 13.2429378531073 ENPP3 3.37690747752802 Organismal Systems Digestive system hsa04978 Mineral absorption 1/12 61/9376 12.8087431693989 MT1G 3.31224706361247 Environmental Information Processing Signal transduction hsa04151 PI3K-Akt signaling pathway 2/12 362/9376 4.31675874769797 HSP90AB1/ITGB8 2.30385398333684 NA NA hsa04519 Cadherin signaling 2/12 404/9376 3.86798679867987 GABRP/KRT8 2.10944767311387 Metabolism Global and overview maps hsa01232 Nucleotide metabolism 1/12 85/9376 9.1921568627451 ENPP3 2.7159517551267 Human Diseases Cardiovascular disease hsa05412 Arrhythmogenic right ventricular cardiomyopathy 1/12 86/9376 9.08527131782946 ITGB8 2.69638265916403 Environmental Information Processing Signaling molecules and interaction hsa04512 ECM-receptor interaction 1/12 89/9376 8.77902621722846 ITGB8 2.63953894658573 Organismal Systems Nervous system hsa04727 GABAergic synapse 1/12 89/9376 8.77902621722846 GABRP 2.63953894658573 Human Diseases Substance dependence hsa05032 Morphine addiction 1/12 91/9376 8.58608058608059 GABRP 2.60311139144598 Organismal Systems Immune system hsa04657 IL-17 signaling pathway 1/12 94/9376 8.31205673758865 HSP90AB1 2.55051719680497 Human Diseases Infectious disease: bacterial hsa05150 Staphylococcus aureus infection 1/12 99/9376 7.89225589225589 DEFB1 2.46786143325207 Human Diseases Cardiovascular disease hsa05410 Hypertrophic cardiomyopathy 1/12 99/9376 7.89225589225589 ITGB8 2.46786143325207 Human Diseases Cardiovascular disease hsa05414 Dilated cardiomyopathy 1/12 105/9376 7.44126984126984 ITGB8 2.37601080318087 Human Diseases Cancer: specific types hsa05215 Prostate cancer 1/12 106/9376 7.37106918238994 HSP90AB1 2.36140753836018 Organismal Systems Immune system hsa04659 Th17 cell differentiation 1/12 109/9376 7.16819571865443 HSP90AB1 2.31871500108058 Organismal Systems Endocrine system hsa04914 Progesterone-mediated oocyte maturation 1/12 110/9376 7.1030303030303 HSP90AB1 2.30484263906907 Organismal Systems Nervous system hsa04724 Glutamatergic synapse 1/12 116/9376 6.73563218390805 DLGAP1 2.22510419745357 Metabolism Nucleotide metabolism hsa00230 Purine metabolism 1/12 128/9376 6.10416666666667 ENPP3 2.08138049305835 Metabolism Energy metabolism hsa00190 Oxidative phosphorylation 1/12 138/9376 5.66183574879227 MT-ATP8 1.97493629308074 Human Diseases Cardiovascular disease hsa05418 Fluid shear stress and atherosclerosis 1/12 142/9376 5.50234741784038 HSP90AB1 1.93523539926419 Organismal Systems Nervous system hsa04723 Retrograde endocannabinoid signaling 1/12 149/9376 5.24384787472036 GABRP 1.86925366301377 NA NA hsa04518 Integrin signaling 1/12 154/9376 5.07359307359307 ITGB8 1.82461400379624 Environmental Information Processing Signaling molecules and interaction hsa04514 Cell adhesion molecule (CAM) interaction 1/12 160/9376 4.88333333333333 ITGB8 1.77353183154081 Cellular Processes Cell growth and death hsa04217 Necroptosis 1/12 168/9376 4.65079365079365 HSP90AB1 1.70924701775204 Organismal Systems Immune system hsa04621 NOD-like receptor signaling pathway 1/12 187/9376 4.17825311942959 HSP90AB1 1.57152291541818 NA NA hsa04082 Neuroactive ligand signaling 1/12 199/9376 3.92629815745394 GABRP 1.4936206349087 Cellular Processes Cellular community - eukaryotes hsa04510 Focal adhesion 1/12 203/9376 3.84893267651888 ITGB8 1.46899415376372 Human Diseases Cardiovascular disease hsa05415 Diabetic cardiomyopathy 1/12 205/9376 3.81138211382114 MT-ATP8 1.45691434688843 NA NA hsa04382 Cornified envelope formation 1/12 217/9376 3.60061443932412 KRT8 1.38748202555725 Human Diseases Cancer: overview hsa05207 Chemical carcinogenesis - receptor activation 1/12 217/9376 3.60061443932412 HSP90AB1 1.38748202555725 Human Diseases Cancer: overview hsa05208 Chemical carcinogenesis - reactive oxygen species 1/12 227/9376 3.44199706314244 MT-ATP8 1.33326602036649 Cellular Processes Cell motility hsa04810 Regulation of actin cytoskeleton 1/12 232/9376 3.36781609195402 ITGB8 1.30728238771948 Cellular Processes Cell motility hsa04820 Cytoskeleton in muscle cells 1/12 233/9376 3.35336194563662 ITGB8 1.30217060037181 Organismal Systems Environmental adaptation hsa04714 Thermogenesis 1/12 235/9376 3.32482269503546 MT-ATP8 1.29202962567255 Human Diseases Infectious disease: bacterial hsa05132 Salmonella infection 1/12 248/9376 3.1505376344086 HSP90AB1 1.2286569186295 Human Diseases Neurodegenerative disease hsa05012 Parkinson disease 1/12 268/9376 2.91542288557214 MT-ATP8 1.13884892672149 Human Diseases Neurodegenerative disease hsa05016 Huntington disease 1/12 308/9376 2.53679653679654 MT-ATP8 0.981706201338249 Human Diseases Infectious disease: viral hsa05165 Human papillomavirus infection 1/12 333/9376 2.34634634634635 ITGB8 0.89550539405749 Human Diseases Neurodegenerative disease hsa05014 Amyotrophic lateral sclerosis 1/12 368/9376 2.1231884057971 MT-ATP8 0.786878883905139 Environmental Information Processing Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction 1/12 370/9376 2.11171171171171 GABRP 0.781038838297555 Human Diseases Neurodegenerative disease hsa05010 Alzheimer disease 1/12 388/9376 2.01374570446735 MT-ATP8 0.730060609433679 Human Diseases Neurodegenerative disease hsa05022 Pathways of neurodegeneration - multiple diseases 1/12 480/9376 1.62777777777778 MT-ATP8 0.505445958901903