category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	48/746	158/9376	3.81823735025622	CDK6/CCND1/CDC20/AURKB/MAD2L1/ESCO2/SGO1/CCNB2/CDC45/CDT1/PTTG1/PKMYT1/CDCA5/BUB1B/KNL1/E2F1/CDK1/YWHAB/CDC6/MCM2/TTK/MCM4/YWHAQ/CCNE2/CDC25C/PLK1/BUB1/CCNA2/DDX11/E2F2/CCNB1/MCM5/PRKDC/TICRR/CCND2/ORC6/ESPL1/MAD2L1BP/TGFB3/ORC1/NDC80/CDC25A/TRIP13/FBXO5/PCNA/CCNE1/ANAPC11/CDC14B	10.5035815581494
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	51/746	268/9376	2.39174102676964	COX7C/GNAS/CALM1/SLC39A14/UCHL1/NDUFB1/NDUFA1/MT-ATP8/COX6C/NDUFC2/UQCR10/PSMA7/NDUFA6/COX7A1/SLC39A7/MT-ND6/NDUFB2/SEM1/COX6B1/NDUFA4/NDUFB10/GNAI2/NDUFB7/COX4I1/NDUFA2/TUBA3E/UQCRH/NDUFA12/NDUFB4/TUBA3D/TXN/SNCA/GNAI1/TUBA1C/NDUFB3/PRKACA/NDUFV3/COX8A/COX7B/SLC25A5/PSMC4/PSMB1/UQCRQ/NDUFB11/COX5B/PSMD12/NDUFA10/PSMC2/NDUFS6/PARK7/TRAP1	6.79616587167642
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	55/746	308/9376	2.2443508234393	COX7C/POLR2J3/CREB3L1/NDUFB1/NDUFA1/MT-ATP8/COX6C/NDUFC2/UQCR10/PSMA7/NDUFA6/COX7A1/MT-ND6/DNALI1/NDUFB2/SEM1/COX6B1/POLR2A/GRIA4/GPX7/NDUFA4/NDUFB10/NDUFB7/COX4I1/NDUFA2/TUBA3E/UQCRH/NDUFA12/NDUFB4/TUBA3D/DNAH9/AP2B1/DCTN5/TUBA1C/NDUFB3/CREB3L2/NDUFV3/COX8A/GRIA2/COX7B/SLC25A5/POLR2I/PSMC4/PSMB1/CLTA/UQCRQ/NDUFB11/COX5B/AP2S1/POLR2G/PSMD12/NDUFA10/DNAH7/PSMC2/NDUFS6	6.52848027259723
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	42/746	205/9376	2.57498201791669	COX7C/GAPDH/COL1A1/NDUFB1/COL1A2/NDUFA1/MT-ATP8/COX6C/NDUFC2/UQCR10/NDUFA6/COX7A1/MT-ND6/PIK3R3/NDUFB2/COX6B1/NDUFA4/NDUFB10/NDUFB7/COX4I1/RAC1/NDUFA2/UQCRH/NDUFA12/NDUFB4/CYBA/NDUFB3/PTPA/NDUFV3/COX8A/MPC2/COX7B/SLC25A5/CTSD/TGFB3/UQCRQ/NDUFB11/COX5B/SLC2A1/NDUFA10/NDUFS6/GYS1	6.70337997309291
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	44/746	227/9376	2.43615877927508	COX7C/NDUFB1/NDUFA1/MT-ATP8/COX6C/NQO1/GSTM5/NDUFC2/UQCR10/NDUFA6/COX7A1/MT-ND6/PIK3R3/CBR1/NDUFB2/COX6B1/NDUFA4/NDUFB10/CYP1B1/NDUFB7/COX4I1/RAC1/NDUFA2/EPHX2/UQCRH/MGST3/NDUFA12/VEGFA/EGFR/NDUFB4/AHR/CYBA/GSTM2/NDUFB3/NDUFV3/COX8A/COX7B/SLC25A5/UQCRQ/NDUFB11/COX5B/NDUFA10/CYP2E1/NDUFS6	6.43988669439064
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	32/746	138/9376	2.91440338811827	COX7C/NDUFB1/NDUFA1/MT-ATP8/ATP6V0D1/COX6C/NDUFC2/UQCR10/NDUFA6/COX7A1/MT-ND6/NDUFB2/COX6B1/ATP6V0E2/NDUFA4/NDUFB10/NDUFB7/COX4I1/NDUFA2/UQCRH/NDUFA12/NDUFB4/NDUFB3/NDUFV3/COX8A/COX7B/ATP6V1C2/UQCRQ/NDUFB11/COX5B/NDUFA10/NDUFS6	6.66091163943738
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	49/746	275/9376	2.23945405800634	CACNA1D/COX7C/CREB3L1/NDUFB1/NDUFA1/MT-ATP8/COX6C/NDUFC2/UQCR10/PSMA7/NDUFA6/COX7A1/MT-ND6/PIK3R3/NDUFB2/SEM1/COX6B1/NDUFA4/NDUFB10/NDUFB7/COX4I1/RAC1/NDUFA2/TUBA3E/UQCRH/NDUFA12/NDUFB4/NOTCH1/TUBA3D/CYBA/TUBA1C/NDUFB3/PRKACA/C1QA/CREB3L2/NDUFV3/COX8A/COX7B/C1QB/SLC25A5/PSMC4/PSMB1/UQCRQ/NDUFB11/COX5B/PSMD12/NDUFA10/PSMC2/NDUFS6	6.13340831346034
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	57/746	368/9376	1.94673038815713	COX7C/NRG2/FUS/NDUFB1/NDUFA1/MT-ATP8/COX6C/NDUFC2/UQCR10/PSMA7/NDUFA6/COX7A1/MT-ND6/DNALI1/NDUFB2/SEM1/COX6B1/GPX7/MAP2K6/NRG1/NDUFA4/NDUFB10/CHCHD10/NEFM/NDUFB7/COX4I1/RAC1/NDUFA2/TUBA3E/UQCRH/NDUFA12/NDUFB4/SEC13/TUBA3D/DNAH9/VCP/HNRNPA3/DCTN5/TUBA1C/NDUFB3/NEFL/NDUFV3/COX8A/GRIA2/COX7B/NUP210/PSMC4/PSMB1/UQCRQ/NDUFB11/COX5B/PSMD12/NDUFA10/DNAH7/PSMC2/SRSF7/NDUFS6	5.44735516496021
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	30/746	157/9376	2.40159833336179	COX7C/NDUFB1/NDUFA1/COX6C/NDUFC2/UQCR10/NDUFA6/COX7A1/PIK3R3/NDUFB2/COX6B1/NDUFA4/NDUFB10/NDUFB7/COX4I1/RAC1/NDUFA2/UQCRH/NDUFA12/NDUFB4/NDUFB3/NDUFV3/COX8A/COX7B/UQCRQ/NDUFB11/COX5B/NDUFA10/CYP2E1/NDUFS6	5.20692287802235
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	13/746	41/9376	3.98509121820441	SEM1/RAD54L/BRIP1/RAD51/XRCC2/BLM/BRCA1/RAD54B/RBBP8/XRCC3/MUS81/RPA3/EME1	5.63173262844803
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	63/746	480/9376	1.64959785522788	CACNA1D/COX7C/FUS/CALM1/UCHL1/NDUFB1/NDUFA1/MT-ATP8/COX6C/NDUFC2/UQCR10/PSMA7/NDUFA6/COX7A1/MT-ND6/DNALI1/NDUFB2/SEM1/COX6B1/GRIA4/GPX7/MAP2K6/NDUFA4/NDUFB10/NEFM/NDUFB7/COX4I1/RAC1/NDUFA2/TUBA3E/FZD7/UQCRH/NDUFA12/NDUFB4/TUBA3D/SNCA/DNAH9/VCP/FZD2/DCTN5/TUBA1C/NDUFB3/NEFL/NDUFV3/COX8A/GRIA2/COX7B/SLC25A5/FZD10/FZD4/WNT11/PSMC4/PSMB1/UQCRQ/NDUFB11/COX5B/PSMD12/NDUFA10/DNAH7/PSMC2/NDUFS6/PARK7/TRAP1	4.29553703712444
Cellular Processes	Cell motility	hsa04814	Motor proteins	32/746	194/9376	2.07313230701197	DYNLL1/DNALI1/KIF11/MYO5B/KIFC1/KIF2C/KIF4A/KIF15/KIF23/CENPE/KIF20A/TUBA3E/MYO10/KIF18B/MYL6B/MYL10/TUBA3D/KIF14/DNAH9/MYL12B/DCTN5/KIF18A/TUBA1C/KIF26A/KIF9/KIF24/KIF20B/MYO15B/TNNT3/DNAH7/KIFAP3/MYL5	4.44053343547585
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	14/746	54/9376	3.25846489921557	BRIP1/FANCI/RAD51/FANCD2/UBE2T/HES1/BLM/BRCA1/RMI2/MUS81/FANCA/RPA3/RMI1/EME1	4.89333929408218
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	11/746	36/9376	3.84033363121835	MCM2/MCM4/FEN1/LIG1/RFC3/MCM5/POLE4/PRIM1/POLE2/PCNA/RPA3	5.01992030537113
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	36/746	235/9376	1.92536649363984	COX7C/GNAS/CREB3L1/NDUFB1/NDUFA1/MT-ATP8/COX6C/NDUFC2/UQCR10/NDUFA6/COX7A1/MT-ND6/NDUFB2/COX6B1/NDUFA4/NDUFB10/NDUFB7/COX4I1/NDUFA2/UQCRH/NDUFA12/NDUFB4/NDUFB3/PRKACA/CREB3L2/NDUFV3/COX8A/DPF1/COX7B/CPT1A/UQCRQ/NDUFB11/COX5B/NDUFA10/SMARCB1/NDUFS6	4.22377233137043
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	26/746	149/9376	2.19313744894471	CACNA1D/NDUFB1/NDUFA1/GABRP/NDUFC2/NDUFA6/MT-ND6/NDUFB2/GRIA4/GNG11/NDUFA4/NDUFB10/GNAI2/NDUFB7/NDUFA2/NDUFA12/NDUFB4/GNAI1/NDUFB3/PRKACA/NDUFV3/GRIA2/RIMS1/NDUFB11/NDUFA10/NDUFS6	4.31621435778656
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	52/746	388/9376	1.68441999944722	CACNA1D/COX7C/CALM1/GAPDH/BACE2/SLC39A14/NDUFB1/NDUFA1/MT-ATP8/COX6C/NDUFC2/UQCR10/PSMA7/NDUFA6/COX7A1/SLC39A7/MT-ND6/PIK3R3/NDUFB2/SEM1/COX6B1/NDUFA4/NDUFB10/NDUFB7/COX4I1/NDUFA2/TUBA3E/FZD7/UQCRH/NDUFA12/NDUFB4/TUBA3D/SNCA/FZD2/TUBA1C/NDUFB3/NDUFV3/COX8A/COX7B/SLC25A5/FZD10/FZD4/WNT11/PSMC4/PSMB1/UQCRQ/NDUFB11/COX5B/PSMD12/NDUFA10/PSMC2/NDUFS6	4.04815074682279
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	14/746	59/9376	2.98232380606171	RRM2/GSTM5/GSTP1/GPX7/ODC1/MGST3/GSTM2/GPX4/IDH1/PRDX6/IDH2/PGD/GGCT/GCLM	4.49068103158429
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	24/746	138/9376	2.1858025410887	IGF1/CALM1/CDC20/MAD2L1/SGO1/CCNB2/PTTG1/PKMYT1/CDK1/YWHAB/YWHAQ/CCNE2/CDC25C/PLK1/BUB1/CCNB1/FBXW11/PRKACA/AURKA/ESPL1/FBXO43/FBXO5/CCNE1/ANAPC11	4.12584202317772
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	13/746	56/9376	2.91765607047108	PTCH1/CCND1/SCUBE2/GLI1/HHIP/SMO/GLI2/PTCH2/FBXW11/PRKACA/CCND2/IQCE/CSNK1D	4.23161775799126
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	33/746	224/9376	1.85158942933742	CREB3L1/MSX1/CCND1/CDC20/PIK3R3/MAD2L1/CCNB2/PTTG1/BUB1B/XPO1/E2F1/HLA-DMB/ELK1/CCNE2/HLA-DRB1/CCNA2/E2F2/HLA-DQA1/PRKACA/CREB3L2/HLA-DPA1/IL1R1/SLC25A5/CCND2/ESPL1/HLA-DRA/TGFB3/ITGB2/SLC2A1/HLA-DOB/ETS1/CCNE1/ANAPC11	3.79267753719104
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	12/746	50/9376	3.01640750670241	CKB/P4HA3/CNDP2/PYCR1/ODC1/GAMT/ALDH7A1/P4HA1/SAT1/P4HA2/L3HYPDH/GOT1	4.20305677254407
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	44/746	333/9376	1.66068481349983	GNAS/ITGA6/CREB3L1/LFNG/HEYL/COL1A1/LLGL1/COL1A2/ATP6V0D1/CDK6/ITGA9/CCND1/VWF/PIK3R3/ITGB1/ATP6V0E2/E2F1/CHD4/LAMB2/PPP2R2C/FZD7/VEGFA/CCNE2/EGFR/NOTCH1/CCNA2/FZD2/PRKACA/CREB3L2/HES1/COL6A6/ATP6V1C2/FZD10/CCND2/MX1/FZD4/HES6/WNT11/ITGA4/SPP1/CCNE1/LLGL2/ITGA2/ITGA11	3.60919070012692
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	25/746	157/9376	2.00133194446816	LIMD1/LLGL1/BMP7/BIRC5/CCND1/FGF1/YWHAB/PPP2R2C/FZD7/GLI2/YWHAQ/CTNNA2/FZD2/AMOT/FBXW11/FZD10/CCND2/FZD4/WNT11/TGFB3/FRMD6/ITGB2/SNAI2/CSNK1D/LLGL2	3.71993750708893
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	30/746	203/9376	1.85739378491528	IGF1/ITGA6/COL1A1/PGF/COL1A2/ITGA9/CCND1/VWF/PIK3R3/ITGB1/PDGFD/PIP5K1B/LAMB2/RAC1/VEGFA/ROCK2/MYL10/ELK1/EGFR/EMP2/DIAPH1/FLT1/MYL12B/COL6A6/CCND2/ITGA4/SPP1/ITGA2/MYL5/ITGA11	3.63096704597143
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	15/746	75/9376	2.51367292225201	IGF1/RRM2/CDK6/CCND1/CCNB2/GTSE1/SIVA1/CDK1/CCNE2/TP53I3/CCNB1/CD82/CCND2/PERP/CCNE1	3.86943455406149
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	33/746	233/9376	1.78006880760336	ITGA6/COL5A1/COL1A1/COL1A2/DAAM2/COL5A3/FLNC/ITGA9/ITGB1/SDC1/LMNB1/ATP1A2/ATP1B1/CSRP2/DIAPH3/DIAPH1/SDC4/NEBL/PDLIM4/SSPN/DSP/COL6A6/SGCD/ATP1A1/DAAM1/FMNL3/ITGA4/TNNT3/FHL2/AMPD2/ITGA2/MYL5/ITGA11	3.54499940758053
NA	NA	hsa04518	Integrin signaling	24/746	154/9376	1.95870617318339	IGF1/FREM1/ITGA6/COL1A1/PGF/COL1A2/ITGA9/CCND1/VWF/PIK3R3/ITGB1/PDGFD/LAMB2/RAC1/VEGFA/EGFR/FLT1/COL6A6/CCND2/ITGA4/ITGB2/SPP1/ITGA2/ITGA11	3.52681743750966
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	24/746	155/9376	1.94606935916285	SEC61B/MRC2/ATP6V0D1/COLEC12/SEC61A1/ITGB1/ATP6V0E2/STX18/HLA-DMB/RAC1/TUBA3E/HLA-DRB1/TUBA3D/CYBA/HLA-DQA1/TUBA1C/VAMP3/HLA-DPA1/ATP6V1C2/HLA-DRA/SEC61G/ITGB2/HLA-DOB/ITGA2	3.49180087239145
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	16/746	87/9376	2.31142337678346	CACNA1D/COX7C/COX6C/UQCR10/COX7A1/COX6B1/ATP1A2/COX4I1/ATP1B1/UQCRH/COX8A/COX7B/ATP1A1/UQCRQ/COX5B/HRC	3.61299798922643
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	16/746	89/9376	2.25948127842877	FREM1/ITGA6/COL1A1/COL1A2/ITGA9/VWF/ITGB1/HMMR/SDC1/LAMB2/SDC4/COL6A6/ITGA4/SPP1/ITGA2/ITGA11	3.50993158162119
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	11/746	51/9376	2.71082373968354	GNAS/SEC61B/KDELR3/ATP6V0D1/KDELR2/SEC61A1/KDELR1/ATP6V0E2/PRKACA/ATP6V1C2/SEC61G	3.60176679416202
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	8/746	31/9376	3.24344893193808	SEC61B/SRP14/SEC61A1/SPCS1/SEC62/SEC61G/SEC11A/IMMP1L	3.67838375715206
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	11/746	54/9376	2.56022242081223	BHMT2/TST/PHGDH/CDO1/PSAT1/DNMT1/LDHB/GCLM/SDSL/MPST/GOT1	3.38048099924877
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	14/746	78/9376	2.25586031484155	MARCKSL1/ITGB1/HLA-DMB/ELK1/HLA-DRB1/CYBA/HLA-DQA1/IRAK1/HLA-DPA1/ITGA4/HLA-DRA/TGFB3/ITGB2/HLA-DOB	3.27448889156941
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	12/746	63/9376	2.39397421166858	POLR2J3/CETN2/POLR2A/LIG1/RFC3/POLE4/POLR2I/XPC/POLE2/POLR2G/PCNA/RPA3	3.2638475615809
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	9/746	41/9376	2.75890930491074	GCSH/CHDH/PHGDH/GAMT/ALDH7A1/SARDH/PSAT1/DMGDH/SDSL	3.31839337522998
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	22/746	155/9376	1.78389691256594	CACNA1D/GNAS/CREB3L1/RASD1/CDK6/CCND1/GNAI2/E2F1/CACNA1H/FZD7/CCNE2/EGFR/AHR/E2F2/GNAI1/FZD2/PRKACA/CREB3L2/FZD10/FZD4/WNT11/CCNE1	2.89324656448531
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	17/746	110/9376	1.94238362174019	IGF1/PIK3R3/MAD2L1/CCNB2/PKMYT1/GNAI2/CDK1/CDC25C/PLK1/BUB1/CCNA2/CCNB1/GNAI1/PRKACA/AURKA/CDC25A/ANAPC11	2.92299167448201
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	27/746	205/9376	1.65534558294645	CDK6/CCND1/PIK3R3/SEM1/NCOR2/MAP2K6/E2F1/HLA-DMB/RAC1/TAPBPL/CCNE2/HLA-DRB1/CCNA2/E2F2/HLA-DQA1/IRAK1/HES1/HLA-DPA1/CCND2/SNW1/HLA-DRA/PSMC4/HLA-DOB/PSMD12/CIR1/PSMC2/CCNE1	2.78925753196153
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	22/746	157/9376	1.76117211113198	CACNA1D/CALM1/CDK6/CCND1/MYBL2/PIK3R3/CCNB2/FOXM1/MAP2K6/E2F1/CDK1/CCNE2/CCNA2/E2F2/CCNB1/FBXW11/SLC25A5/CCND2/TGFB3/CDC25A/ETS1/CCNE1	2.82774628452888
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	9/746	44/9376	2.57080185230319	HMGB1/FEN1/LIG1/RFC3/NEIL3/POLE4/NTHL1/POLE2/PCNA	3.07050657706319
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	10/746	53/9376	2.37138954929435	GNAS/ATP2B1/DNM1/ATP1A2/ATP1B1/AP2B1/PRKACA/ATP1A1/CLTA/AP2S1	2.94354434121242
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	11/746	63/9376	2.1944763606962	PTCH1/GLI1/HHIP/SMO/FZD7/GLI2/PTCH2/FZD2/FZD10/FZD4/WNT11	2.79674381677242
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	13/746	82/9376	1.9925456091022	TK1/RRM2/GSTM5/NME4/XDH/GSTP1/MGST3/UCK2/NME3/GSTM2/NME6/UCKL1/CYP2E1	2.65402933392396
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	15/746	100/9376	1.88525469168901	CD24/ITGA6/CD34/HLA-DMB/HLA-DRB1/HLA-DQA1/KIT/HLA-DPA1/IL1R1/CD22/ITGA4/HLA-DRA/CD9/HLA-DOB/ITGA2	2.61660110953377
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	41/746	362/9376	1.4234888095626	IGF1/ITGA6/CREB3L1/COL1A1/PGF/DDIT4/COL1A2/CDK6/ITGA9/ANGPT1/CCND1/VWF/PIK3R3/ITGB1/PDGFD/GNG11/FGF1/LAMB2/YWHAB/RAC1/PPP2R2C/VEGFA/YWHAQ/CCNE2/EGFR/MAGI2/FLT1/KIT/CREB3L2/THEM4/COL6A6/CCND2/BRCA1/ITGA4/FGF9/EPHA2/SPP1/GYS1/CCNE1/ITGA2/ITGA11	2.41594532353627
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	9/746	49/9376	2.30847513268042	LFNG/GALNT17/OGT/GALNT2/GALNT16/B4GALT2/XXYLT1/GALNT9/POFUT2	2.69986580934957
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	12/746	75/9376	2.01093833780161	GAPDH/PHGDH/PYCR1/PFKP/IDH1/PSAT1/TPI1/IDH2/PFKM/GPT2/SDSL/GOT1	2.58428335395945
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	13/746	85/9376	1.92222046995742	ENPP3/TYMS/TK1/RRM2/NME4/XDH/UCK2/NME3/NUDT16/NME6/GMPR/UCKL1/AMPD2	2.51109211684543
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	14/746	95/9376	1.85218004797517	ATP6V0D1/ANGPT1/ATP6V0E2/HLA-DMB/VEGFA/HLA-DRB1/FLT1/HLA-DQA1/HLA-DPA1/ATP6V1C2/HLA-DRA/TGFB3/ITGB2/HLA-DOB	2.45440050862576
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	25/746	204/9376	1.54024076118383	IGF1/CD63/PTCH1/COL1A1/COL1A2/CCND1/PIK3R3/ITGB1/HOXD10/SDC1/RDX/RAC1/SMO/FZD7/VEGFA/ROCK2/ELK1/EGFR/SDC4/FZD2/PRKACA/FZD10/FZD4/WNT11/ITGA2	2.2936125875076
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	22/746	174/9376	1.58910357153863	SEC61B/RRBP1/SSR3/SSR2/UBXN4/SEC31A/SEC61A1/CKAP4/SEC62/ERLEC1/TMEM258/DAD1/ERP29/SEC13/VCP/P4HB/SVIP/SEC61G/MAN1B1/DNAJC10/OSTC/UBE2D2	2.30608239050676
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	16/746	116/9376	1.73356753258759	GCSH/GAPDH/PHGDH/PFKP/ACAT2/IDH1/PSAT1/TPI1/IDNK/IDH2/PFKM/PGP/PGD/GPT2/SDSL/GOT1	2.33729352924756
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	16/746	116/9376	1.73356753258759	PIK3R3/ITGB1/THY1/GNAI2/RAC1/ROCK2/MYL10/CTNNA2/CLDN3/CYBA/MYL12B/GNAI1/ITGA4/RAPGEF3/ITGB2/MYL5	2.33729352924756
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	8/746	44/9376	2.28515720204728	PTPRN2/CPE/HLA-DMB/HLA-DRB1/HLA-DQA1/HLA-DPA1/HLA-DRA/HLA-DOB	2.51214603271594
Organismal Systems	Digestive system	hsa04978	Mineral absorption	10/746	61/9376	2.06038764119017	FTH1/ATP2B1/MT1F/ATP1A2/ATP1B1/MT1G/SLC31A1/ATP1A1/CLCN2/SLC30A1	2.4427993702285
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	11/746	70/9376	1.97502872462658	CCND1/HLA-DMB/RAC1/HLA-DRB1/HLA-DQA1/SSPN/HLA-DPA1/SGCD/HLA-DRA/ITGB2/HLA-DOB	2.40732408161976
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	13/746	89/9376	1.83582853872338	GNAS/GUCY1A2/PDGFD/GNAI2/CDK1/HTR2B/TUBA3E/EGFR/TUBA3D/GNAI1/TUBA1C/PRKACA/CSNK1D	2.32929304717044
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	19/746	148/9376	1.61350626766176	IGF1/HEYL/CDK6/CCND1/PIK3R3/FGF1/E2F1/FZD7/EGFR/NOTCH1/E2F2/KIT/FZD2/HES1/FZD10/FZD4/BRCA1/WNT11/FGF9	2.21179933294953
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	27/746	232/9376	1.46269760562078	ITGA6/ITGA9/PIK3R3/RGCC/WASF2/ITGB1/PDGFD/FGF1/PIP5K1B/RDX/RAC1/IQGAP2/ROCK2/MYL10/EGFR/DIAPH3/DIAPH1/IQGAP3/MYL12B/ABI2/ITGA4/FGF9/ITGB2/ARPC3/ITGA2/MYL5/ITGA11	2.09808360428704
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	15/746	112/9376	1.68326311757947	ITGA6/SOCS1/ITGB1/MAP2K6/GNAI2/LAMB2/HLA-DMB/HLA-DRB1/HLA-DQA1/GNAI1/IRAK1/HLA-DPA1/HLA-DRA/TGFB3/HLA-DOB	2.13868769364524
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	5/746	23/9376	2.73225317636088	LIG1/EXO1/RFC3/PCNA/RPA3	2.4453975416098
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	13/746	93/9376	1.75686817146646	WASF2/RAC1/HEG1/ROCK2/MYL10/CTNNA2/EGFR/ARHGAP29/MYL12B/NECTIN1/SNAI1/SNAI2/MYL5	2.15658805498834
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	7/746	39/9376	2.25586031484155	BHMT2/GCSH/TYMS/CHDH/ALDH7A1/SARDH/DMGDH	2.31057257981416
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	26/746	226/9376	1.44591805262284	CACNA1D/EDN3/GNAS/CALM1/CREB3L1/PTCH1/ATP2B1/EDNRA/PIK3R3/GLI1/GRIA4/HHIP/HTR1E/GNAI2/ATP1A2/RAC1/ATP1B1/ROCK2/GNAI1/PRKACA/CREB3L2/GRIA2/PDE4C/ATP1A1/SSTR2/RAPGEF3	1.99502517962069
Human Diseases	Immune disease	hsa05310	Asthma	6/746	32/9376	2.35656836461126	HLA-DMB/HLA-DRB1/HLA-DQA1/HLA-DPA1/HLA-DRA/HLA-DOB	2.25995563371503
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	8/746	49/9376	2.05197789571593	GNAS/CREB3L1/GNAI2/RGS9/GNAI1/PRKACA/CREB3L2/GRIA2	2.17061760051701
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	9/746	59/9376	1.91720816103967	ENPP3/TYMS/TK1/RRM2/NME4/UCK2/NME3/NME6/UCKL1	2.077808518568
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	13/746	97/9376	1.68441999944722	CACNA1D/GNAS/CALM1/GUCY1A2/RASD1/GRIA4/GNG11/GNAI2/CACNA1H/GNAI1/PRKACA/GRIA2/RPS6KA5	1.99208389957424
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	13/746	99/9376	1.6503913125897	KRT19/KRT17/KRT18/HLA-DMB/KRT10/HLA-DRB1/HLA-DQA1/C1QA/HLA-DPA1/C1QB/HLA-DRA/ITGB2/HLA-DOB	1.91266189068162
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	20/746	170/9376	1.47863113073648	CACNA1D/LLGL1/CCND1/ITGB1/RDX/RAC1/PPP2R2C/TUBA3E/MYL6B/ROCK2/CLDN3/TUBA3D/MYL12B/TUBA1C/AMOT/PRKACA/SYMPK/ARPC3/PCNA/LLGL2	1.85156759624216
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	20/746	170/9376	1.47863113073648	NQO1/GSTM5/CDK6/CCND1/PIK3R3/GSTP1/E2F1/FZD7/MGST3/ELK1/EGFR/E2F2/GSTM2/FZD2/DPF1/FZD10/FZD4/WNT11/TGFB3/SMARCB1	1.85156759624216
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	24/746	212/9376	1.42283372957661	IGF1/GNAS/CALM1/PGF/ANGPT1/PIK3R3/ITGB1/PDGFD/FGF1/MAP2K6/GNAI2/RAC1/VEGFA/EGFR/MAGI2/FLT1/KIT/GNAI1/SIPA1L1/FGF9/RAPGEF3/ITGB2/EPHA2/RGS14	1.83081586896283
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	19/746	160/9376	1.49249329758713	ITGA6/CD34/ITGA9/ITGB1/NLGN3/SDC1/HLA-DMB/CNTN1/CLDN3/HLA-DRB1/HLA-DQA1/SDC4/HLA-DPA1/NECTIN1/CD22/ITGA4/HLA-DRA/ITGB2/HLA-DOB	1.84730555784379
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	10/746	71/9376	1.77019219876902	PIK3R3/SLC16A3/EGFR/PFKP/KIT/IDH1/IDH2/PFKM/LDHB/SLC2A1	1.91522479271711
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	6/746	35/9376	2.15457679050172	HSD17B14/PFKP/TPI1/PFKM/SORD/PMM2	2.01191585535342
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	13/746	101/9376	1.61771029649882	GNAS/CALM1/CREB3L1/GNAI2/FZD7/KIT/GNAI1/FZD2/PRKACA/CREB3L2/FZD10/FZD4/WNT11	1.83500910039795
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	7/746	44/9376	1.99951255179137	GNAS/CREB3L1/DYNLL1/DCTN5/PRKACA/CREB3L2/STX4	1.95378548836868
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	24/746	217/9376	1.39004954225918	CACNA1D/GNAS/CREB3L1/BIRC5/GSTM5/CCND1/PIK3R3/GNAI2/E2F1/CYP1B1/CDC6/EPHX2/MGST3/VEGFA/KPNA2/EGFR/AHR/GSTM2/GNAI1/PRKACA/CREB3L2/CHRNA3/FGF9/CDC25A	1.70913065620747
Human Diseases	Cancer: specific types	hsa05218	Melanoma	10/746	73/9376	1.72169378236439	IGF1/CDK6/CCND1/PIK3R3/PDGFD/FGF1/E2F1/EGFR/E2F2/FGF9	1.8199210043946
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	5/746	28/9376	2.2443508234393	B3GALT1/B4GALT2/A4GALT/ABO/ST3GAL4	1.93870690633564
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	4/746	20/9376	2.51367292225201	SQLE/DHCR7/EBP/DHCR24	1.99228556055991
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	10/746	75/9376	1.67578194816801	GNAS/CREB3L1/DUOX1/GPX7/ATP1A2/ATP1B1/PAX8/PRKACA/CREB3L2/ATP1A1	1.72751588722476
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	13/746	105/9376	1.55608323758458	IGF1/CACNA1D/GNAS/ITGA6/ITGA9/ITGB1/PRKACA/SSPN/SGCD/ITGA4/TGFB3/ITGA2/ITGA11	1.68469317747912
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	6/746	38/9376	1.98447862283053	IGF1/HSD11B2/PIK3R3/ATP1A2/ATP1B1/ATP1A1	1.78780771801642
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	11/746	86/9376	1.60758152004489	CACNA1D/ITGA6/ITGA9/ITGB1/CTNNA2/SSPN/DSP/SGCD/ITGA4/ITGA2/ITGA11	1.66416191492814
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	8/746	57/9376	1.76398099807159	HACD3/FADS2/SCD/HSD17B8/ACAA2/ACAT2/CPT1A/MECR	1.70092428904246
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	15/746	128/9376	1.47285522788204	GUCY1A2/ENPP3/RRM2/NME4/XDH/PDE7B/PGM1/NME3/PDE9A/NUDT16/NME6/PDE4C/GMPR/AMPD2/PDE5A	1.58364897242406
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	10/746	77/9376	1.63225514431949	CDK6/CCND1/PIK3R3/E2F1/RAC1/VEGFA/EGFR/E2F2/RAD51/TGFB3	1.63783166942696
Human Diseases	Immune disease	hsa05330	Allograft rejection	6/746	39/9376	1.93359455557847	HLA-DMB/HLA-DRB1/HLA-DQA1/HLA-DPA1/HLA-DRA/HLA-DOB	1.71765757329116
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	12/746	98/9376	1.53898342178695	CACNA1D/GNAS/CALM1/CREB3L1/ATP2B1/CACNA1H/ATP1A2/ATP1B1/PRKACA/CREB3L2/ATP1A1/NR4A2	1.57692455226194
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	10/746	78/9376	1.61132879631539	CALM1/ITGB1/GNAI2/PYCARD/GNAI1/IRAK1/C1QA/IRF8/C1QB/ITGB2	1.59395860270002
Organismal Systems	Endocrine system	hsa04924	Renin secretion	9/746	69/9376	1.63935190581653	CACNA1D/EDN3/GNAS/CALM1/GUCY1A2/EDNRA/GNAI2/GNAI1/PRKACA	1.56714545169538
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	5/746	31/9376	2.0271555824613	PGM1/PFKP/IDNK/PFKM/PGD	1.68413568804961
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	5/746	31/9376	2.0271555824613	GCSH/HYI/ACAT2/PGP/AFMID	1.68413568804961
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	16/746	142/9376	1.41615375901522	CALM1/NQO1/GSTM5/SUMO2/PIK3R3/GSTP1/SDC1/MAP2K6/RAC1/MGST3/VEGFA/CYBA/TXN/GSTM2/SDC4/IL1R1	1.46910458119243
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	7/746	50/9376	1.75957104557641	HLA-DMB/HLA-DRB1/HLA-DQA1/HLA-DPA1/ITGA4/HLA-DRA/HLA-DOB	1.58327134605806
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	6/746	41/9376	1.8392728699405	CCND1/E2F1/VEGFA/EGFR/E2F2/RPS6KA5	1.58338893531643
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4/746	23/9376	2.1858025410887	CA4/ATP1A2/ATP1B1/ATP1A1	1.67398083512526
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	18/746	166/9376	1.36283471688362	CACNA1D/CALM1/CREB3L1/KCNMB1/GUCY1A2/ADRA2C/ATP2B1/EDNRA/GNAI2/ATP1A2/ATP1B1/ROCK2/ADRA2A/GNAI1/CREB3L2/SLC25A5/ATP1A1/PDE5A	1.38670064545286
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	8/746	62/9376	1.62172446596904	LFNG/HEYL/NCOR2/NOTCH1/HES1/TLE1/SNW1/CIR1	1.44402708769861
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	11/746	93/9376	1.48658076047162	ITGA6/CDK6/CCND1/PIK3R3/ITGB1/E2F1/LAMB2/CCNE2/E2F2/CCNE1/ITGA2	1.38644257399155
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	9/746	73/9376	1.54952440412795	PSIP1/XPO1/SERINC5/MX1/BICD1/SAMHD1/CHMP6/SMARCB1/CDK9	1.38575532994537
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	13/746	115/9376	1.42077165170766	GNAS/CREB3L1/MAFB/WNK2/PTHLH/GNAI2/EGFR/GNAI1/PRKACA/CREB3L2/PDE4C/MMP15/NR4A2	1.33479971400717
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	8/746	63/9376	1.59598280777905	PTGDS/CBR1/EPHX2/PTGR1/CBR3/GPX4/PTGR2/CYP2E1	1.39543258234699
Organismal Systems	Immune system	hsa04611	Platelet activation	14/746	126/9376	1.39648495680667	GNAS/GUCY1A2/COL1A1/COL1A2/VWF/PIK3R3/ITGB1/GNAI2/ROCK2/MYL12B/GNAI1/PRKACA/VAMP8/ITGA2	1.31731845005699
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	5/746	34/9376	1.8482889134206	DBP/BHLHE41/FBXW11/RORB/CSNK1D	1.45684374020467
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	6/746	44/9376	1.71386790153546	TMEM258/DAD1/B4GALT2/MAN1B1/OSTC/B4GALNT4	1.39542494402143
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	12/746	106/9376	1.42283372957661	IGF1/CREB3L1/CCND1/PIK3R3/GSTP1/PDGFD/E2F1/CCNE2/EGFR/E2F2/CREB3L2/CCNE1	1.28715943204148
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	15/746	139/9376	1.35629833934461	KRT19/GNAS/CALM1/CREB3L1/KRT17/KRT18/PIK3R3/GNAI2/KRT10/EGFR/GREB1/GNAI1/PRKACA/CREB3L2/CTSD	1.24424349978012
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	9/746	75/9376	1.50820375335121	TOP2A/BIRC5/GSTM5/PIK3R3/GSTP1/MGST3/GSTM2/SLC31A1/BRCA1	1.29913215385741
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	16/746	150/9376	1.34062555853441	CCND1/PIK3R3/FGF1/E2F1/FZD7/CTNNA2/CCNE2/EGFR/E2F2/FZD2/FZD10/FZD4/WNT11/FGF9/TGFB3/CCNE1	1.23641934160645
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	10/746	86/9376	1.46143774549536	CACNA1D/GNAS/CREB3L1/KCNMB1/ATP1A2/ATP1B1/PRKACA/CREB3L2/ATP1A1/SLC2A1	1.26387504693517
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	6/746	45/9376	1.67578194816801	HLA-DMB/HLA-DRB1/HLA-DQA1/HLA-DPA1/HLA-DRA/HLA-DOB	1.3359752198093
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	19/746	184/9376	1.29782025877142	UNC5B/PTCH1/BMP7/SEMA5A/PIK3R3/ITGB1/EFNB2/EFNB1/GNAI2/RAC1/SMO/SRGAP3/ROCK2/MYL12B/GNAI1/PLXNA2/EPHA2/MYL5/SEMA3D	1.19952083104558
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	9/746	76/9376	1.4883589671229	GNAS/CALM1/GNAI2/ATP1A2/ATP1B1/GNAI1/PRKACA/ATP1A1/SSTR2	1.25676518827933
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	12/746	108/9376	1.39648495680667	PNN/SRRM1/SUMO2/XPO1/UPF3A/KPNA2/UBE2I/SEC13/RBM8A/SAP18/PHAX/NUP210	1.2184149901706
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	6/746	46/9376	1.63935190581653	PSMA7/SEM1/PSMC4/PSMB1/PSMD12/PSMC2	1.27799075496524
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	10/746	88/9376	1.42822325127955	F3/F13A1/SERPINA5/VWF/F10/C1QA/C1QB/F7/ITGB2/CLU	1.18658848995893
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	11/746	99/9376	1.39648495680667	IGF1/CACNA1D/ITGA6/ITGA9/ITGB1/SSPN/SGCD/ITGA4/TGFB3/ITGA2/ITGA11	1.16597754679891
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	16/746	154/9376	1.30580411545559	NAPRT/QPRT/NQO1/NME4/MMAB/VKORC1/PTS/NME3/NADSYN1/NME6/PDXK/PSAT1/PMM2/GCLM/PPCS/AFMID	1.12496958611394
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	9/746	78/9376	1.45019591668385	DNM1/PIK3R3/WASF2/ITGB1/RAC1/CTNNA2/ARHGAP10/CLTA/ARPC3	1.17382603048268
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	13/746	122/9376	1.33925196677361	IGF1/CREB3L1/CCND1/SCD/PIK3R3/PPP2R2C/CCNA2/PFKP/CREB3L2/PFKM/CPT1A/GYS1/RAB14	1.10888675456945
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	13/746	122/9376	1.33925196677361	IGF1/CACNA1D/GNAS/SOCS1/CREB3L1/SOCS2/PIK3R3/MAP2K6/GNAI2/GNAI1/PRKACA/CREB3L2/SSTR2	1.10888675456945
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	18/746	178/9376	1.27095821911619	SFRP4/SFRP1/DAAM2/CCND1/SOX17/RAC1/PRICKLE1/FZD7/ROCK2/FZD2/FBXW11/PRKACA/FZD10/CCND2/FZD4/DAAM1/TLE1/WNT11	1.07303844406688
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	9/746	79/9376	1.43183900634608	GSTM5/CBR1/GSTP1/CYP1B1/MGST3/CBR3/GSTM2/AKR7A2/CYP2E1	1.13321849037319
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	9/746	79/9376	1.43183900634608	ATP6V0D1/DNM1/ATP6V0E2/SLC6A9/AP2B1/ATP6V1C2/RIMS1/CLTA/AP2S1	1.13321849037319
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	4/746	28/9376	1.79548065875144	HACD3/ACAA2/THEM4/MECR	1.23936418727582
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	8/746	69/9376	1.45720169405914	CACNA1D/GNAS/CALM1/CREB3L1/GRIA4/PRKACA/CREB3L2/GRIA2	1.12066852203583
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	5/746	38/9376	1.65373218569211	NAPRT/QPRT/ENPP3/NADSYN1/NMRK1	1.18717402287087
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/746	10/9376	2.51367292225201	TST/MPST	1.40800636916922
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	22/746	227/9376	1.21807938963754	GNAS/CALM1/CREB3L1/CDK6/CCND1/PIK3R3/GNG11/MAP2K6/GNAI2/E2F1/RAC1/TAPBPL/VEGFA/ROCK2/ELK1/EGFR/E2F2/GNAI1/PRKACA/CREB3L2/CCL4/IL1R1	0.977890871061284
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	16/746	163/9376	1.23370450171878	CREB3L1/BIRC5/PIK3R3/MAP2K6/E2F1/YWHAB/YWHAQ/ELK1/CCNE2/CCNA2/E2F2/IRAK1/CREB3L2/TGFB3/PCNA/CCNE1	0.884932201413475
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	11/746	107/9376	1.29207486657814	GNAS/CALM1/CREB3L1/PFKP/PRKACA/CREB3L2/PFKM/CPT1A/LDHB/SLC2A1/GYS1	0.893345160014832
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	3/746	21/9376	1.79548065875144	CHPF/B3GAT3/CHSY1	1.07291923244828
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	13/746	130/9376	1.25683646112601	GNAS/CREB3L1/COL1A1/COL1A2/PIK3R3/GNG11/GNAI2/VEGFA/EGFR/GNAI1/PRKACA/CREB3L2/RXFP1	0.866963997680162
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	5/746	42/9376	1.49623388229286	FTH1/SLC39A14/SAT1/GPX4/GCLM	0.947603846839041
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	15/746	154/9376	1.22419135823962	CACNA1D/GNAS/CALM1/CREB3L1/ATP2B1/GNAI2/ATP1A2/ATP1B1/PPP2R2C/GNAI1/PRKACA/CREB3L2/ATP1A1/RAPGEF3/RPS6KA5	0.824738604689475
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/746	12/9376	2.09472743521001	NQO1/VKORC1	1.11561816430999
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	4/746	32/9376	1.57104557640751	PGM1/B4GALT2/PFKP/PFKM	0.951325197591505
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	3/746	22/9376	1.71386790153546	ASPA/CNDP2/ALDH7A1	0.985553413373024
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	5/746	43/9376	1.46143774549536	ALDH7A1/ECI1/ACAA2/ACAT2/CPT1A	0.891633476532265
Human Diseases	Cancer: specific types	hsa05214	Glioma	8/746	76/9376	1.32298574855369	IGF1/CALM1/CDK6/CCND1/PIK3R3/E2F1/EGFR/E2F2	0.831186222470787
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	6/746	54/9376	1.39648495680667	HLA-DMB/HLA-DRB1/HLA-DQA1/HLA-DPA1/HLA-DRA/HLA-DOB	0.859050507859756
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	7/746	65/9376	1.35351618890493	PLPP5/PLPP2/GPAT3/DGKB/ALDH7A1/MBOAT1/LPIN2	0.840847961663352
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	11/746	110/9376	1.25683646112601	IGF1/GAPDH/ANGPT1/PIK3R3/VEGFA/EGFR/FLT1/PFKP/PFKM/LDHB/SLC2A1	0.796629759108557
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	13/746	133/9376	1.22848676651414	IGF1/TNFSF10/CCND1/PIK3R3/CCNB2/PLK2/EGFR/PLK1/CCNB1/PLK4/CCND2/TGFB3/HOMER2	0.780243303040189
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	10/746	99/9376	1.26953177891516	IGF1/GNAS/ASIC2/CALM1/PIK3R3/MAP2K6/HTR2B/PRKACA/IL1R1/ASIC3	0.792635374857564
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	4/746	33/9376	1.52343813469819	IDH1/IDH2/GPT2/GOT1	0.885582058311219
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	4/746	33/9376	1.52343813469819	STX18/VAMP3/VAMP8/STX4	0.885582058311219
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	7/746	66/9376	1.33300836786091	HLA-DMB/HLA-DRB1/HLA-DQA1/HLA-DPA1/HLA-DRA/TGFB3/HLA-DOB	0.798181996899131
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	3/746	23/9376	1.63935190581653	ICMT/ACAT2/MVK	0.902564128640722
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	2/746	13/9376	1.93359455557847	FEN1/PRKDC	0.990312199114663
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	8/746	78/9376	1.28906303705231	SYNJ2/PIP5K1B/ITPK1/ISYNA1/INPP5F/TPI1/IP6K2/PIK3C2B	0.753693458265332
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	7/746	67/9376	1.31311272057941	GAPDH/PGM1/PFKP/ALDH7A1/TPI1/PFKM/LDHB	0.756199266878494
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	4/746	34/9376	1.47863113073648	POLR2J3/POLR2A/POLR2I/POLR2G	0.821996793367015
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	3/746	24/9376	1.57104557640751	EXT1/HS6ST1/B3GAT3	0.823519329839273
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	10/746	103/9376	1.22022957390874	FUS/PNN/SRRM1/UPF3A/PPP2R2C/RBM8A/SAP18/GSPT2/CSTF3/SYMPK	0.660744832126591
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	8/746	80/9376	1.25683646112601	IGF1/NRG2/PIK3R3/PDGFD/NRG1/VEGFA/EGFR/GAS6	0.678271028822656
NA	NA	hsa04082	Neuroactive ligand signaling	18/746	199/9376	1.13683700001347	PENK/GNAS/ADRA2C/GABRP/GRIA4/GNG11/HTR1E/GNAI2/HTR2B/P2RY14/ADRA2A/SLC6A9/GNAI1/PRKACA/GRIA2/OPRL1/CHRNA3/SLC17A9	0.573626717019094
Organismal Systems	Digestive system	hsa04970	Salivary secretion	9/746	93/9376	1.21629334947678	GNAS/CALM1/GUCY1A2/ATP2B1/ATP1A2/ATP1B1/PRKACA/ATP1A1/CST1	0.616297092994765
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	4/746	36/9376	1.39648495680667	GALNT17/GALNT2/GALNT16/GALNT9	0.700735597949552
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	7/746	70/9376	1.25683646112601	GSTM5/CBR1/GSTP1/CYP1B1/MGST3/GSTM2/CYP2E1	0.634123469688983
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	8/746	82/9376	1.22618191329366	HLA-DMB/CD74/TAPBPL/HLA-DRB1/HLA-DQA1/HLA-DPA1/HLA-DRA/HLA-DOB	0.604801862180841
NA	NA	hsa03272	Virion - Hepatitis viruses	5/746	48/9376	1.30920464700626	CD63/EGFR/CLDN3/EPCAM/CD9	0.631425353899514
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	5/746	48/9376	1.30920464700626	CACNA1D/PIK3R3/ATP1A2/ATP1B1/ATP1A1	0.631425353899514
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	4/746	37/9376	1.35874212013622	ASRGL1/ASPA/GPT2/GOT1	0.642810110321941
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	4/746	37/9376	1.35874212013622	PGM1/PMM2/NANS/NAGK	0.642810110321941
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	8/746	83/9376	1.21140863722988	XDH/EPHX2/ACOX2/IDH1/MVK/IDH2/PXMP2/PRDX5	0.568765779176759
Organismal Systems	Nervous system	hsa04730	Long-term depression	6/746	60/9376	1.25683646112601	IGF1/GNAS/GUCY1A2/GNAI2/GNAI1/GRIA2	0.58676907477533
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/746	27/9376	1.39648495680667	HACD3/FADS2/SCD	0.606562658417672
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	18/746	205/9376	1.1035637219643	CREB3L1/ATP6V0D1/CDK6/CCND1/CDC20/PIK3R3/CHD4/CDK1/YWHAB/RAC1/YWHAQ/CCNE2/CCNA2/PRKACA/CREB3L2/CCND2/SNW1/CCNE1	0.440784067282699
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/746	16/9376	1.57104557640751	A4GALT/ABO	0.672113304981855
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	12/746	133/9376	1.13398778447459	CACNA1D/GNAS/CALM1/CREB3L1/GRIA4/GNG11/GNAI2/PPP2R2C/GNAI1/PRKACA/CREB3L2/GRIA2	0.457545411143197
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	9/746	98/9376	1.15423756634021	CALM1/PIK3R3/SYNJ2/PIP5K1B/ITPK1/DGKB/INPP5F/IP6K2/PIK3C2B	0.4512587872121
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	9/746	98/9376	1.15423756634021	PIK3R3/WASF2/MARCKSL1/PIP5K1B/ASAP1/RAC1/PLPP2/MYO10/ARPC3	0.4512587872121
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	12/746	134/9376	1.12552518906806	CACNA1D/EDN3/GNAS/CALM1/RAMP1/KCNMB1/GUCY1A2/EDNRA/MYL6B/ROCK2/PRKACA/PPP1R14A	0.430278806541346
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	3/746	28/9376	1.34661049406358	CBR1/PCBD1/PTS	0.540021468215991
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	3/746	28/9376	1.34661049406358	ATP6V0D1/ATP6V0E2/ATP6V1C2	0.540021468215991
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	9/746	99/9376	1.14257860102364	IGF1/GNAS/CCND1/PIK3R3/E2F1/EGFR/NOTCH1/E2F2/PRKACA	0.419293202916214
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	9/746	99/9376	1.14257860102364	PIK3R3/WASF2/PDGFD/PIP5K1B/RAC1/PLPP2/EGFR/DGKB/GPCPD1	0.419293202916214
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	2/746	17/9376	1.47863113073648	ACOX2/CYP46A1	0.58071137534478
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	15/746	173/9376	1.08974259635203	IL33/CDK6/TNFSF10/PIK3R3/XPO1/HLA-DMB/KPNA2/HLA-DRB1/HLA-DQA1/PYCARD/HLA-DPA1/SLC25A5/MX1/HLA-DRA/HLA-DOB	0.350272969854348
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	3/746	29/9376	1.3001756494407	RASSF2/LIMD1/FRMD6	0.475979217392957
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	9/746	101/9376	1.11995328219149	F3/COL1A1/COL1A2/CCND1/PIK3R3/RAC1/VEGFA/DIAPH1/TGFB3	0.356340772837366
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	7/746	77/9376	1.14257860102364	CDK6/CCND1/PIK3R3/E2F1/BCR/E2F2/TGFB3	0.369344164673351
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	6/746	65/9376	1.16015673334708	CACNA1D/GNAS/CREB3L1/CACNA1H/PRKACA/CREB3L2	0.380937187625574
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/746	18/9376	1.39648495680667	HSD17B8/MECR	0.495018124532066
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	2/746	18/9376	1.39648495680667	FUCA1/MAN2C1	0.495018124532066
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	2/746	18/9376	1.39648495680667	TCN2/MMAB	0.495018124532066
NA	NA	hsa04517	IgSF CAM signaling	25/746	299/9376	1.05086660629265	DYNLL1/UNC5B/PIK3R3/ITGB1/NLGN3/RDX/RAC1/SRGAP3/TUBA3E/CNTN1/MYL6B/MAGI2/TUBA3D/MYL12B/TUBA1C/CADM4/PLXNA2/PPFIA3/LRFN5/NECTIN1/KCNQ3/ITGA4/RIMS1/ITGB2/ARPC3	0.262813000138291
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	4/746	42/9376	1.19698710583429	CYP1B1/ALDH7A1/ACAT2/AFMID	0.376164840667003
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	10/746	115/9376	1.09290127054435	CACNA1D/CREB3L1/PIK3R3/GNG11/GNAI2/GNAI1/PRKACA/CREB3L2/CHRNA3/KCNQ3	0.294707566087793
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	9/746	103/9376	1.09820661651787	COL5A1/COL1A1/COL1A2/COL5A3/ATP1A2/ATP1B1/COL26A1/COL6A6/ATP1A1	0.294644870773387
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	9/746	103/9376	1.09820661651787	GNAS/PIK3R3/GNAI2/PPP2R2C/GNAI1/IRAK1/C1QA/C1QB/TGFB3	0.294644870773387
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	9/746	103/9376	1.09820661651787	GNAS/COL1A1/COL1A2/PIK3R3/LAMB2/PRKACA/IL1R1/TGFB3/ITGB2	0.294644870773387
Human Diseases	Substance dependence	hsa05032	Morphine addiction	8/746	91/9376	1.10491117461627	GNAS/GABRP/GNG11/GNAI2/PDE7B/GNAI1/PRKACA/PDE4C	0.295665836526085
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	10/746	116/9376	1.08347970786725	CACNA1D/GNAS/GRIA4/GNG11/GNAI2/GNAI1/PRKACA/GRIA2/SHANK2/HOMER2	0.265983119963522
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	9/746	104/9376	1.08764693751289	PEMT/PLPP5/PLPP2/GPAT3/PLD3/DGKB/GPCPD1/MBOAT1/LPIN2	0.264250828846316
NA	NA	hsa04981	Folate transport and metabolism	3/746	31/9376	1.21629334947678	BHMT2/TYMS/ABCC5	0.354636975314648
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	12/746	142/9376	1.06211531926141	SOCS1/UBE2C/CDC20/UBE2I/FBXW11/BRCA1/UBE2Q2/UBE2D2/UBE2R2/UBA3/TRIM37/ANAPC11	0.219279288273437
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	5/746	56/9376	1.12217541171965	TMEM258/DAD1/B4GALT2/MAN1B1/OSTC	0.269599773277254
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	6/746	70/9376	1.07728839525086	PIK3R3/RAC1/VEGFA/TGFB3/SLC2A1/ETS1	0.190823316706288
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	7/746	83/9376	1.05998255757615	AURKB/EZH2/OGT/SFMBT1/RBBP7/UBE2D2/YAF2	0.161374797850457
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	9/746	109/9376	1.03775487615909	CREB3L1/PIK3R3/OGT/PPARGC1B/PTPA/CREB3L2/CPT1A/SLC2A1/GYS1	0.116564517842095
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	26/746	323/9376	1.01169498418812	SOCS1/DDIT4/FSCN1/CDK6/CCND1/PIK3R3/HOXD10/CDCA5/E2F1/KIF23/EZH2/CYP1B1/RDX/VEGFA/CCNE2/EGFR/UBE2I/CDC25C/NOTCH1/E2F2/CCND2/BRCA1/DNMT1/CDC25A/RPS6KA5/CCNE1	0.0628860467214423
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/746	21/9376	1.19698710583429	ENPP3/PPCS	0.26568999769984
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	10/746	122/9376	1.03019382059509	CCND1/PIK3R3/ATP1A2/ATP1B1/NOTCH1/PFKP/PRKACA/ATP1A1/PFKM/SLC2A1	0.0986922140677826
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	5/746	59/9376	1.06511564502204	GNAS/PIK3R3/GNAI2/GNAI1/PRKACA	0.147510508154964
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	5/746	59/9376	1.06511564502204	CCND1/PIK3R3/CTNNA2/ELK1/EGFR	0.147510508154964
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	4/746	47/9376	1.06964805202213	CACNA1D/SOCS1/SOCS2/PIK3R3	0.140731076812027
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	6/746	73/9376	1.03301626941863	CDK6/CCND1/PIK3R3/E2F1/EGFR/E2F2	0.0832583065976667
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	16/746	200/9376	1.0054691689008	GAPDH/TNFSF10/MYO5B/WASF2/ITGB1/RAC1/TUBA3E/MYO10/ROCK2/CLDN3/TUBA3D/PYCARD/TUBA1C/IRAK1/IL1R1/ARPC3	0.0229857820845529
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	19/746	238/9376	1.00335683871404	IGF1/CALM1/PGF/ANGPT1/PIK3R3/PDGFD/GNG11/FGF1/RGL2/RAC1/VEGFA/ELK1/EGFR/FLT1/KIT/PRKACA/FGF9/EPHA2/ETS1	0.0154220828166406
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	11/746	138/9376	1.00182616466566	PIK3R3/WASF2/ITGB1/MAP2K6/PIP5K1B/RAC1/ROCK2/PYCARD/IRAK1/ITGA4/ARPC3	0.00635389675577028
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	3/746	36/9376	1.047363717605	ENPP3/PGM1/GYS1	0.0837092111750405
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/746	23/9376	1.09290127054435	GPT2/GOT1	0.131147422156181
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	6/746	76/9376	0.992239311415267	FADS2/ANGPTL4/SCD/ACOX2/PLTP/CPT1A	-0.0199717091463054
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	5/746	63/9376	0.997489254861909	PLOD1/NSD2/EZH2/ALDH7A1/ACAT2	-0.00587865207843421
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	7/746	89/9376	0.988523059312589	CACNA1D/GABRP/GNG11/GNAI2/GNAI1/PRKACA/PLCL1	-0.0319840217310676
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	4/746	50/9376	1.0054691689008	SDC1/HBA2/TGFB3/ITGB2	0.0114000901664495
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	9/746	115/9376	0.983611143489917	CACNA1D/GNAS/GNG11/HTR1E/GNAI2/HTR2B/GNAI1/PRKACA/RAPGEF3	-0.0519898165519998
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	3/746	37/9376	1.01905659010217	HGD/PNMT/GOT1	0.0341464469833712
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	12/746	154/9376	0.979353086591693	CACNA1D/GNAS/CALM1/GUCY1A2/CCND1/GNAI2/MYL6B/ROCK2/ELK1/EGFR/GNAI1/PRKACA	-0.0759543395839198
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	14/746	180/9376	0.977539469764671	SRSF2/PIK3R3/HLA-DMB/CD74/TAPBPL/HLA-DRB1/SRSF9/HLA-DQA1/IRAK1/HLA-DPA1/NECTIN1/HLA-DRA/HLA-DOB/SRSF7	-0.0894553728009331
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	14/746	181/9376	0.972138699213485	CALM1/MRC2/ATP6V0D1/HLA-DMB/CD74/HLA-DRB1/HLA-DQA1/IRAK1/HLA-DPA1/CTSD/HLA-DRA/TGFB3/ITGB2/HLA-DOB	-0.111279320120725
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	3/746	38/9376	0.992239311415267	PGM1/PMM2/NAGK	-0.014093367420224
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	6/746	78/9376	0.966797277789235	LSM7/DHX36/PFKP/LSM3/NUDT16/PFKM	-0.0865716861693591
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	12/746	157/9376	0.960639333344717	CD24/ANO4/SIRPA/ODC1/RAC1/DUSP7/C1QA/GAS6/C1QB/CPT1A/SLC2A1/RAB14	-0.146224457337949
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	11/746	144/9376	0.960083407804588	CCND1/SCD/MAP2K6/TRA2B/ALDH7A1/IRAK1/C1QA/C1QB/CPT1A/CYP2E1/LPIN2	-0.141917665759945
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	11/746	144/9376	0.960083407804588	PSMA7/PIK3R3/SEM1/AFG3L2/VLDLR/GRIA2/SLC25A5/PSMC4/PSMB1/PSMD12/PSMC2	-0.141917665759945
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	4/746	52/9376	0.966797277789235	IGF1/GNAS/CYP1B1/PRKACA	-0.0705868636253304
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	19/746	248/9376	0.962898901669117	GAPDH/DYNLL1/TNFSF10/MAP2K6/S100A10/RAC1/TUBA3E/ROCK2/MYL10/TUBA3D/TXN/PYCARD/MYL12B/DCTN5/TUBA1C/IRAK1/ARPC3/PIK3C2B/MYL5	-0.174090248549263
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	23/746	300/9376	0.963574620196604	IGF1/CACNA1D/PGF/ANGPT1/PDGFD/FGF1/MAP2K6/CACNA1H/RAC1/VEGFA/ELK1/EGFR/FLT1/DUSP10/KIT/IRAK1/PRKACA/DUSP7/IL1R1/FGF9/TGFB3/EPHA2/RPS6KA5	-0.18852420872391
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	12/746	158/9376	0.954559337564055	IGF1/DDIT4/PIK3R3/FZD7/SEC13/FZD2/PRR5/ATP6V1C2/FZD10/FZD4/WNT11/LPIN2	-0.169357525514626
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	7/746	93/9376	0.94600593848194	HLA-DMB/NOTCH1/HLA-DRB1/HLA-DQA1/HLA-DPA1/HLA-DRA/HLA-DOB	-0.153848388002025
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	7/746	93/9376	0.94600593848194	CACNA1D/GNAS/CALM1/MAP2K6/ELK1/EGFR/PRKACA	-0.153848388002025
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	2/746	26/9376	0.966797277789235	HES1/NKX6-1	-0.0498430046318605
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	3/746	41/9376	0.919636434970248	GABRP/GRIA4/GRIA2	-0.151615504597109
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	8/746	109/9376	0.922448778808077	HLA-DMB/HLA-DRB1/AHR/HLA-DQA1/HLA-DPA1/IL1R1/HLA-DRA/HLA-DOB	-0.239431872805293
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	10/746	137/9376	0.91739887673431	BIRC5/TNFSF10/PIK3R3/LMNB1/TUBA3E/TUBA3D/CSF2RB/TUBA1C/CTSV/CTSD	-0.286340914262646
Genetic Information Processing	Transcription	hsa03040	Spliceosome	18/746	243/9376	0.930989971204448	FUS/SRSF2/LSM7/TRA2B/RBM25/SRSF9/HNRNPA3/CWC15/DDX46/LSM3/SNRPE/SF3B2/RBM8A/BUD31/SNW1/PRPF6/SNRPD3/SRSF7	-0.320448520407394
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	9/746	125/9376	0.904922252010724	PIK3R3/GNAI2/RAC1/PPP2R2C/ROCK2/GNAI1/CTSD/CERS1/ORMDL3	-0.314622086294503
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	5/746	71/9376	0.885096099384511	SOCS1/CCND1/SOCS2/PIK3R3/CCND2	-0.285729717323046
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	5/746	71/9376	0.885096099384511	ATP6V0D1/ATP6V0E2/RAC1/EGFR/ATP6V1C2	-0.285729717323046
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/746	29/9376	0.866783766293797	CALM1/RGS9	-0.211236850096474
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/746	14/9376	0.897740329375718	B4GALT2	-0.112572871210633
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5/746	73/9376	0.860846891182195	GSTM5/GSTP1/MGST3/GSTM2/CYP2E1	-0.350907367851568
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	6/746	87/9376	0.866783766293797	BIRC5/CCND1/PIK3R3/RAC1/EGFR/TGFB3	-0.367013424523013
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	2/746	30/9376	0.837890974084003	IDH1/IDH2	-0.261459598110372
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/746	30/9376	0.837890974084003	TYMS/ABCC5	-0.261459598110372
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	3/746	45/9376	0.837890974084003	ABCC6/ABCC5/ABCB9	-0.320478583540607
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	11/746	156/9376	0.886230837973465	CDK6/CCND1/PIK3R3/E2F1/YWHAB/PPP2R2C/YWHAQ/EGFR/CLDN3/E2F2/MX1	-0.421280203943272
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	17/746	238/9376	0.897740329375718	RPS20/RPL31/RPL27A/RPS26/F13A1/RPL38/RPS27/VWF/PIK3R3/RPL13A/RPL30/RPS29/EGFR/IRAK1/C1QA/C1QB/MX1	-0.469804254394182
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/746	31/9376	0.81086223298452	HSD17B14/ALDH7A1	-0.310112381052833
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/746	31/9376	0.81086223298452	CNDP2/ALDH7A1	-0.310112381052833
Organismal Systems	Digestive system	hsa04976	Bile secretion	6/746	90/9376	0.837890974084003	GNAS/ATP1A2/ATP1B1/PRKACA/ATP1A1/SLC2A1	-0.45432199771291
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	3/746	47/9376	0.802236039016599	ALDH7A1/ACAT2/LDHB	-0.399602492471169
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	15/746	214/9376	0.880960136303275	CALM1/PIK3R3/CCNB2/GNG11/MAP2K6/GNAI2/CDK1/RAC1/TAPBPL/CDC25C/CCNB1/GNAI1/IRAK1/FBXW11/SAMHD1	-0.51790942918222
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/746	16/9376	0.785522788203753	GOT1	-0.252436922058913
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/746	32/9376	0.785522788203753	BIRC5/BOK	-0.357305238532021
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	3/746	48/9376	0.785522788203753	ALDH7A1/ACAA2/ACAT2	-0.43798290443897
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/746	17/9376	0.739315565368238	CDO1	-0.316282011019744
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/746	17/9376	0.739315565368238	PSTK	-0.316282011019744
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/746	17/9376	0.739315565368238	CA4	-0.316282011019744
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	10/746	149/9376	0.843514403440272	GNAS/DNM1/PIK3R3/PDGFD/PIP5K1B/PLPP2/EGFR/DGKB/KIT/RAPGEF3	-0.566091844032962
NA	NA	hsa04081	Hormone signaling	15/746	219/9376	0.860846891182195	IGF1/PENK/GNAS/RAMP1/ADRA2C/PIK3R3/PTHLH/GNG11/GNAI2/ADRA2A/GNAI1/PRKACA/OPRL1/SSTR2/RAPGEF3	-0.612615552057168
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	4/746	65/9376	0.773437822231388	CACNA1D/PIK3R3/CACNA1H/SPP1	-0.538884360449982
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4/746	66/9376	0.761719067349094	HSD11B2/CYP1B1/HSD17B8/CYP2E1	-0.571131445939291
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/746	51/9376	0.739315565368238	PAFAH1B3/PLPP2/PLD3	-0.54881430426331
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	17/746	250/9376	0.854648793565684	CD63/ATP6V0D1/HYAL2/SLC29A1/LAPTM4B/ATP6V0E2/ROGDI/FUCA1/AP2B1/BLOC1S4/ATP6V1C2/VAMP8/CTSV/CTSD/CLTA/ABCB9/AP2S1	-0.684854110934862
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	4/746	67/9376	0.750350126045376	CALM1/PRKACA/GRIA2/RAPGEF3	-0.602929996939926
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/746	19/9376	0.661492874276845	HYAL2	-0.434236129546148
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/746	19/9376	0.661492874276845	GCSH	-0.434236129546148
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	3/746	52/9376	0.725097958341926	LRPAP1/ANGPTL4/PLTP	-0.584424156599786
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	4/746	68/9376	0.739315565368238	CCND1/PIK3R3/CCNA2/KIT	-0.634294613751951
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	2/746	37/9376	0.679371060068111	CCND1/PAX8	-0.574517216355198
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	17/746	254/9376	0.841189757446539	CACNA1D/GNAS/CALM1/ATP2B1/EDNRA/PDGFD/FGF1/CACNA1H/HTR2B/VEGFA/EGFR/ORAI2/FLT1/PRKACA/SLC25A5/FGF9/HRC	-0.754397060468473
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/746	20/9376	0.628418230563003	NANS	-0.48907328851152
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	9/746	143/9376	0.791015954554829	HLA-DMB/HLA-DRB1/HLA-DQA1/C1QA/HLA-DPA1/C1QB/HLA-DRA/SNRPD3/HLA-DOB	-0.740388026714352
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	5/746	86/9376	0.730718872747678	NRG2/PIK3R3/NRG1/ELK1/EGFR	-0.737559293029723
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	6/746	102/9376	0.739315565368238	GNAS/ATP2B1/ATP1A2/RAC1/ATP1B1/ATP1A1	-0.778271800200952
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	3/746	56/9376	0.673305247031789	PYCARD/VCP/ITGB2	-0.720904722901247
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	7/746	120/9376	0.733154602323503	CALM1/BEX3/MAGED1/PIK3R3/RAC1/IRAK1/RPS6KA5	-0.864944658447735
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	6/746	105/9376	0.718192263500575	EDAR/UBE2I/IRAK1/CCL4/IL1R1/EDARADD	-0.853756306526333
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/746	23/9376	0.546450635272176	B4GALT2	-0.640269284328359
Genetic Information Processing	Translation	hsa03010	Ribosome	14/746	222/9376	0.792599570079463	RPS20/RPL31/RPL27A/RPS26/RPL38/RPS27/RPL13A/MRPL51/RPL30/RPS29/MRPS6/MRPS7/MRPL20/MRPL17	-0.919454705135044
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	5/746	90/9376	0.698242478403336	IGF1/CREB3L1/PIK3R3/PRKACA/CREB3L2	-0.84569677266295
Human Diseases	Infectious disease: viral	hsa05162	Measles	8/746	136/9376	0.739315565368238	CDK6/CCND1/PIK3R3/CCNE2/IRAK1/CCND2/MX1/CCNE1	-0.90032274728635
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	16/746	253/9376	0.79483728766862	PIK3R3/WASF2/ITGB1/RAC1/ROCK2/MYL10/EGFR/DIAPH1/PYCARD/MYL12B/FBXW11/IL1R1/ARPC3/UBE2D2/RPS6KA5/MYL5	-0.972611743927772
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	3/746	60/9376	0.628418230563003	PIK3R3/RAC1/VEGFA	-0.848916427597711
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/746	43/9376	0.584575098198142	PLPP2/ACAT2	-0.802723125811983
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	6/746	109/9376	0.691836584106058	PIK3R3/MAP2K6/RAC1/IRAK1/CCL4/SPP1	-0.951424654100069
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	3/746	62/9376	0.60814667473839	IGF1/PIK3R3/PRKACA	-0.910124737009656
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/746	26/9376	0.483398638894617	FADS2	-0.775507618650999
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/746	26/9376	0.483398638894617	TCN2	-0.775507618650999
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	8/746	142/9376	0.708076879507609	SOCS1/PIK3R3/SIRPA/MAP2K6/RAC1/CYBA/IL1R1/FHL2	-1.03054600464556
NA	NA	hsa04382	Cornified envelope formation	13/746	217/9376	0.752943502057054	KRT19/S100A13/ITGA6/KRT17/KRT8/KRT18/PCSK6/S100A10/EPHX2/PPP2R2C/KRT10/CLDN3/DSP	-1.08255949232463
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/746	46/9376	0.546450635272176	FTH1/MMAB	-0.90659289472557
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/746	27/9376	0.465494985602224	ACAT2	-0.817712694781449
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	8/746	144/9376	0.698242478403336	IGF1/PIK3R3/DLX5/FZD7/FZD2/FZD10/FZD4/WNT11	-1.07285518966287
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	4/746	83/9376	0.605704318614942	IL33/PYCARD/CCL4/SAMHD1	-1.06079814612845
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	6/746	117/9376	0.644531518526157	CHD4/MORF4L1/DPF1/RBBP7/SMARCB1/BCL7C	-1.13752681168818
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/746	30/9376	0.418945487042002	CYP2E1	-0.937161139423174
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	11/746	196/9376	0.70536740165235	CALM1/CDK6/CCND1/PIK3R3/GNG11/MAP2K6/E2F1/RAC1/VEGFA/PREX1/E2F2	-1.22556724397642
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	3/746	69/9376	0.546450635272176	PIK3R3/MAP2K6/RAC1	-1.11171612626194
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	9/746	168/9376	0.673305247031789	SOCS1/CCND1/SOCS2/PIK3R3/CNTFR/IL20RA/EGFR/CSF2RB/CCND2	-1.25621449127719
NA	NA	hsa04519	Cadherin signaling	25/746	404/9376	0.777745334855201	KRT19/LIMD1/KRT17/DAAM2/GABRP/KRT8/KRT18/CIB2/YWHAB/RAC1/PRICKLE1/FZD7/KRT10/ROCK2/YWHAQ/CTNNA2/EGFR/FZD2/ABI2/DSP/FZD10/FZD4/DAAM1/WNT11/ARPC3	-1.34259983598775
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/746	32/9376	0.392761394101877	LDHB	-1.01162045659378
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/746	32/9376	0.392761394101877	ATG4C	-1.01162045659378
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	7/746	138/9376	0.637525741150872	CALM1/SOCS1/SOCS2/PIK3R3/ELK1/PRKACA/GYS1	-1.26118091137406
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	7/746	140/9376	0.628418230563003	CALM1/CCND1/GNG11/GNAI2/GNAI1/PRKACA/SPP1	-1.30234518365304
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/746	55/9376	0.457031440409456	PLPP2/CERS1	-1.18733816440973
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	14/746	250/9376	0.703828418230563	DNM1/DAB2/PIP5K1B/ASAP1/ACAP1/EGFR/AP2B1/ARF4/IQSEC3/CLTA/CHMP6/AP2S1/ARPC3/AGAP1	-1.3954774115242
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/746	36/9376	0.349121239201668	SORD	-1.15034356237398
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/746	37/9376	0.339685530034055	HBA2	-1.18318087969377
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	11/746	216/9376	0.640055605203058	CALM1/TNFSF10/PIK3R3/MAP2K6/RAC1/ROCK2/CYBA/PYCARD/IRAK1/VLDLR/MIB2	-1.57349079915677
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	10/746	201/9376	0.62529177170448	IGF1/FUS/HOXA10/ETV1/NSD2/CCNA2/FLT1/PAX8/CCND2/CDK9	-1.57883911132256
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	5/746	119/9376	0.528082546691599	CREB3L1/PIK3R3/MAP2K6/CREB3L2/RPS6KA5	-1.52318986877363
Organismal Systems	Sensory system	hsa04742	Taste transduction	3/746	86/9376	0.438431323648606	ASIC2/HTR1E/PRKACA	-1.53813302901568
Human Diseases	Substance dependence	hsa05034	Alcoholism	9/746	191/9376	0.59222660471906	GNAS/CALM1/CREB3L1/SLC29A1/GNG11/GNAI2/GNAI1/PRKACA/CREB3L2	-1.67396219149465
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/746	44/9376	0.28564465025591	TAF7L	-1.39637777771485
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	9/746	193/9376	0.586089541457723	PIK3R3/GNG11/GNAI2/RAC1/ROCK2/PREX1/GNAI1/PRKACA/CCL4	-1.70821454937258
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/746	68/9376	0.369657782684119	ALDH1A2/CYP26A1	-1.53374202732399
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	3/746	90/9376	0.418945487042002	PIK3R3/MAP2K6/EGFR	-1.62844632256303
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	2/746	70/9376	0.359096131750287	CPT1A/SLC2A1	-1.58237729522449
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	3/746	91/9376	0.414341690481101	PIK3R3/RAC1/CD22	-1.65053107674868
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	7/746	168/9376	0.523681858802502	FTH1/IL33/HMGB1/TNFSF10/PYCARD/SLC25A5/CHMP6	-1.83154992847018
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	7/746	169/9376	0.520583149578819	DDIT4/HMGB1/PIK3R3/PRKACA/VAMP8/CTSD/ATG4C	-1.84904392957392
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	3/746	100/9376	0.377050938337802	TNFSF10/IL20RA/CCL4	-1.84128841251141
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	8/746	195/9376	0.515625214820925	HMGB1/VWF/PIK3R3/RAC1/CLCN5/CYBA/SLC25A5/ITGB2	-2.00957164077482
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	3/746	105/9376	0.359096131750287	CALM1/PIK3R3/PYCARD	-1.94166322824296
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	18/746	370/9376	0.6114339540613	PGRMC1/PENK/EDN3/ADRA2C/EDNRA/GABRP/GRIA4/HTR1E/HTR2B/P2RY14/ADRA2A/NMUR1/NR3C1/GRIA2/OPRL1/CHRNA3/SSTR2/RXFP1	-2.24207116224043
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	3/746	110/9376	0.342773580307092	BMP7/TGFB3/NOG	-2.03851946138939
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	4/746	133/9376	0.377995928158197	TNFSF10/PIK3R3/RAC1/ITGB2	-2.12403772403274
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	13/746	298/9376	0.548284362236177	IL33/BMP7/TNFSF10/TNFRSF19/GDF11/EDAR/CNTFR/IL20RA/CSF2RB/CCL4/IL1R1/TNFRSF18/TGFB3	-2.32984925510887
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	6/746	187/9376	0.403263035655403	TXNIP/CYBA/TXN/PYCARD/CARD16/NLRP1	-2.42336746104724
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	2/746	105/9376	0.239397421166858	E2F1/VCP	-2.30429886881516
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	2/746	122/9376	0.206038764119017	PIK3R3/PPP2R2C	-2.59515989393667
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	3/746	183/9376	0.206038764119017	XPO1/PWP2/FBLL1	-3.18893647482146
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	3/746	449/9376	0.0839757100975059	CALM1/OR2C3/PRKACA	-5.84826504916536