category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	4/41	42/9376	21.7793263646922	SAT1/FTH1/ACSL5/SLC39A14	8.94422295809273
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	3/41	50/9376	13.7209756097561	SAT1/CKB/CNDP2	5.97692934523871
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	5/41	235/9376	4.86559418785677	MT-CO1/ACSL5/SLC25A29/GNAS/MT-ND1	3.97716621648167
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	3/41	83/9376	8.2656479576844	ACSL5/IDH1/XDH	4.40611506204681
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	5/41	268/9376	4.26647251547142	MT-CO1/UBC/SLC39A14/GNAS/MT-ND1	3.59546693985141
Human Diseases	Substance dependence	hsa05032	Morphine addiction	3/41	91/9376	7.53899758777808	GNG11/GABRP/GNAS	4.15395057341013
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	2/41	43/9376	10.6364152013613	ACSL5/ACADVL	4.19719845513638
Organismal Systems	Immune system	hsa04611	Platelet activation	3/41	126/9376	5.44483159117305	COL1A2/GNAS/MYL12A	3.32881854585312
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	3/41	128/9376	5.35975609756098	ENPP3/XDH/PAPSS1	3.29127122971282
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	3/41	130/9376	5.27729831144465	COL1A2/GNG11/GNAS	3.25450300827823
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	2/41	57/9376	8.02396234488661	ACSL5/ACADVL	3.52496940644837
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	3/41	149/9376	4.60435423146178	GNG11/GABRP/MT-ND1	2.93907552111822
Organismal Systems	Digestive system	hsa04978	Mineral absorption	2/41	61/9376	7.49780087964814	FTH1/MT1G	3.37411819557433
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	2/41	65/9376	7.03639774859287	NR4A1/GNAS	3.23635958287849
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	2/41	75/9376	6.09821138211382	DUOX1/GNAS	2.93767706840156
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/41	10/9376	22.8682926829268	PAPSS1	4.58519918460085
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	2/41	76/9376	6.01797175866496	UBC/ACSL5	2.91081054813963
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	2/41	85/9376	5.38077474892396	ENPP3/XDH	2.68874466329515
NA	NA	hsa04082	Neuroactive ligand signaling	3/41	199/9376	3.44748130898394	GNG11/GABRP/GNAS	2.31268222049257
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	2/41	89/9376	5.13894217593861	GNG11/GABRP	2.5999622661204
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	3/41	205/9376	3.34657941701368	MT-CO1/COL1A2/MT-ND1	2.25125269728286
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	2/41	97/9376	4.71511189338698	GNG11/GNAS	2.43740436055636
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	2/41	98/9376	4.66699850671976	NR4A1/GNAS	2.41833795637569
NA	NA	hsa04382	Cornified envelope formation	3/41	217/9376	3.16151511745532	KRT18/KRT8/S100A10	2.13493432678274
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/41	17/9376	13.4519368723099	PAPSS1	3.40539153967678
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	4/41	362/9376	2.52688316938418	COL1A2/GNG11/NR4A1/SGK1	1.96345847917953
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	3/41	224/9376	3.06271777003484	B2M/MSX1/ANAPC4	2.07074308066137
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	2/41	103/9376	4.44044518115084	COL1A2/GNAS	2.32671682439255
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/41	18/9376	12.7046070460705	ACSL5	3.29398771730061
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	3/41	227/9376	3.02224132373482	B2M/GNG11/GNAS	2.04399345583354
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/41	21/9376	10.8896631823461	ENPP3	3.00669695463765
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	2/41	115/9376	3.97709437963945	GNG11/GNAS	2.12879080821369
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	2/41	115/9376	3.97709437963945	SGK1/GNAS	2.12879080821369
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	2/41	116/9376	3.94280908326325	GNG11/GNAS	2.11351821246476
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/41	22/9376	10.3946784922395	CNDP2	2.92358001965837
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	2/41	133/9376	3.4388410049514	GNG11/GNAS	1.87725486161689
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	2/41	134/9376	3.41317801237714	MYL6/GNAS	1.8645721026407
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	2/41	138/9376	3.31424531636621	MT-CO1/MT-ND1	1.81501560414767
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	2/41	139/9376	3.29040182488156	KRT18/GNAS	1.80290986376565
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/41	30/9376	7.62276422764228	IDH1	2.40772808564407
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/41	31/9376	7.37686860739575	CNDP2	2.35678013069339
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	2/41	142/9376	3.22088629336998	UBC/ANAPC4	1.76724176364828
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/41	33/9376	6.92978566149298	IDH1	2.2613781757504
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	2/41	154/9376	2.96990814063985	MYL6/GNAS	1.63348135549087
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/41	36/9376	6.35230352303523	ENPP3	2.13225406722336
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	2/41	155/9376	2.9507474429583	NR4A1/GNAS	1.62292440023905
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/41	37/9376	6.18061964403428	ASRGL1	2.09243891179166
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/41	37/9376	6.18061964403428	HGD	2.09243891179166
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	2/41	157/9376	2.91315830355756	CD24/SGK1	1.60206167484581
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/41	38/9376	6.01797175866496	ENPP3	2.05406168521056
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/41	38/9376	6.01797175866496	SGK1	2.05406168521056
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/41	41/9376	5.57763236168947	GABRP	1.94668679693953
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	2/41	169/9376	2.70630682638187	UBC/VMP1	1.48341209052556
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	2/41	170/9376	2.69038737446198	MYL6/MYL12A	1.47399367902988
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	1/41	44/9376	5.19733924611973	GNAS	1.84941106077158
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/41	46/9376	4.97136797454931	FTH1	1.78936372438742
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/41	49/9376	4.66699850671976	GNAS	1.70552539417459
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	1/41	51/9376	4.48397895743663	GNAS	1.65331877087326
Human Diseases	Substance dependence	hsa05034	Alcoholism	2/41	191/9376	2.39458562124888	GNG11/GNAS	1.29045448648397
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/41	52/9376	4.39774859287054	GNAS	1.62821662979724
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	1/41	53/9376	4.31477220432582	GNAS	1.6037408315422
Cellular Processes	Cell motility	hsa04814	Motor proteins	2/41	194/9376	2.35755594669349	MYL6/MYL12A	1.26622348036883
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	2/41	196/9376	2.33349925335988	GNG11/UBC	1.2503162550089
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	3/41	368/9376	1.86426299045599	MT-CO1/HNRNPA2B1/MT-ND1	1.1209236750488
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	2/41	203/9376	2.25303376186471	COL1A2/MYL12A	1.19612206089416
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	2/41	204/9376	2.24198947871832	COL1A2/DDX5	1.18856074594514
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/41	59/9376	3.87598181066556	ENPP3	1.46856948029699
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	1/41	59/9376	3.87598181066556	IDH1	1.46856948029699
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1/41	59/9376	3.87598181066556	GNAS	1.46856948029699
Organismal Systems	Nervous system	hsa04730	Long-term depression	1/41	60/9376	3.81138211382114	GNAS	1.44777531723625
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	3/41	388/9376	1.76816696002012	MT-CO1/SLC39A14/MT-ND1	1.02414243163735
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	2/41	214/9376	2.13722361522681	B2M/GNG11	1.11526485828445
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/41	63/9376	3.6298877274487	PTGDS	1.38797961283004
NA	NA	hsa04081	Hormone signaling	2/41	219/9376	2.08842855551843	GNG11/GNAS	1.08010451862257
Genetic Information Processing	Translation	hsa03010	Ribosome	2/41	222/9376	2.06020654801143	RPS27/RPL30	1.05945355057086
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/41	68/9376	3.36298421807747	CYP26A1	1.29600744249259
NA	NA	hsa04519	Cadherin signaling	3/41	404/9376	1.69814054576189	KRT18/KRT8/GABRP	0.950625186687019
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	2/41	227/9376	2.01482754915655	MT-CO1/MT-ND1	1.02574348814344
Organismal Systems	Endocrine system	hsa04924	Renin secretion	1/41	69/9376	3.31424531636621	GNAS	1.27864353550917
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/41	69/9376	3.31424531636621	GNAS	1.27864353550917
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	1/41	70/9376	3.26689895470383	ACSL5	1.26159530334807
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	1/41	71/9376	3.22088629336998	IDH1	1.24485198117529
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	2/41	238/9376	1.92170526747284	RPS27/RPL30	0.954498777600201
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/41	75/9376	3.04910569105691	IDH1	1.1807299360846
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	1/41	76/9376	3.00898587933248	GNAS	1.1653667198359
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	2/41	248/9376	1.84421715184894	MYL12A/S100A10	0.892920104758537
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1/41	82/9376	2.78881618084474	XDH	1.07818109407722
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	1/41	82/9376	2.78881618084474	B2M	1.07818109407722
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	2/41	253/9376	1.80777017256339	UBC/MYL12A	0.863176565468981
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	1/41	86/9376	2.65910380034033	GNAS	1.02431924453876
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	1/41	87/9376	2.62853938884216	MT-CO1	1.01133215896615
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	1/41	89/9376	2.56947108796931	COL1A2	0.985895775546021
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	1/41	89/9376	2.56947108796931	GNAS	0.985895775546021
Organismal Systems	Digestive system	hsa04976	Bile secretion	1/41	90/9376	2.54092140921409	GNAS	0.973436910487775
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	1/41	93/9376	2.45895620246525	MYL12A	0.937043945976007
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	1/41	93/9376	2.45895620246525	GNAS	0.937043945976007
Organismal Systems	Digestive system	hsa04970	Salivary secretion	1/41	93/9376	2.45895620246525	GNAS	0.937043945976007
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	2/41	275/9376	1.66314855875831	MT-CO1/MT-ND1	0.739695582780361
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	3/41	480/9376	1.42926829268293	MT-CO1/UBC/MT-ND1	0.639841563587084
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	1/41	99/9376	2.30992855383099	GNAS	0.86832405711024
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	1/41	99/9376	2.30992855383099	GNAS	0.86832405711024
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	1/41	99/9376	2.30992855383099	KRT18	0.86832405711024
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	1/41	100/9376	2.28682926829268	CD24	0.857355554010136
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	1/41	101/9376	2.26418739434919	GNAS	0.846516813886984
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	1/41	101/9376	2.26418739434919	COL1A2	0.846516813886984
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	1/41	102/9376	2.24198947871832	GNAS	0.835804802647989
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	1/41	103/9376	2.22022259057542	COL1A2	0.825216587245841
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	1/41	103/9376	2.22022259057542	GNAS	0.825216587245841
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	1/41	105/9376	2.17793263646922	UBC	0.804400291253703
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	1/41	105/9376	2.17793263646922	GNAS	0.804400291253703
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	1/41	107/9376	2.13722361522681	GNAS	0.784046323540546
NA	NA	hsa04517	IgSF CAM signaling	2/41	299/9376	1.52965168447671	MYL6/MYL12A	0.616843779773782
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	1/41	110/9376	2.07893569844789	ANAPC4	0.754338307087987
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	2/41	308/9376	1.48495407031992	MT-CO1/MT-ND1	0.573509500661932
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	1/41	115/9376	1.98854718981972	GNG11	0.706867133795254
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	1/41	116/9376	1.97140454163162	IDH1	0.697660341639555
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	1/41	116/9376	1.97140454163162	MYL12A	0.697660341639555
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	1/41	122/9376	1.87445021991204	GNAS	0.644274087453792
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	2/41	333/9376	1.37347103200762	COL1A2/GNAS	0.459878576614063
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	1/41	133/9376	1.7194205024757	SGK1	0.553761246869919
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	1/41	138/9376	1.6571226581831	ANAPC4	0.515367956027268
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	1/41	140/9376	1.63344947735192	GNG11	0.500442797651433
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	1/41	144/9376	1.58807588075881	ACADVL	0.471288802398495
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	1/41	149/9376	1.53478474382059	GNAS	0.436076103705583
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	1/41	154/9376	1.48495407031992	GNAS	0.402132168396288
NA	NA	hsa04518	Integrin signaling	1/41	154/9376	1.48495407031992	COL1A2	0.402132168396288
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	1/41	157/9376	1.45657915177878	MT-CO1	0.38233530348127
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	1/41	158/9376	1.44736029638777	ANAPC4	0.375827049482438
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	1/41	158/9376	1.44736029638777	SGK1	0.375827049482438
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	1/41	168/9376	1.36120789779326	FTH1	0.313075893382033
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	1/41	180/9376	1.27046070460705	B2M	0.242807083152518
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	1/41	184/9376	1.24284199363733	MYL12A	0.220469287556265
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	1/41	193/9376	1.18488563123973	GNG11	0.171992665905889
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	1/41	201/9376	1.13772600412571	DDX5	0.130807108318085
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	1/41	205/9376	1.11552647233789	B2M	0.110833360495952
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	1/41	212/9376	1.07869305108145	GNAS	0.0768037065655451
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	1/41	217/9376	1.05383837248511	GNAS	0.0531763060958313
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	1/41	226/9376	1.01187135765163	GNAS	0.0119719382257458
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	1/41	232/9376	0.985702270815812	MYL12A	-0.0146138066121413
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	1/41	233/9376	0.981471788966817	COL1A2	-0.0189796192002671
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	1/41	238/9376	0.960852633736421	GNG11	-0.0405401971362327
Genetic Information Processing	Transcription	hsa03040	Spliceosome	1/41	243/9376	0.941082003412627	DDX5	-0.0616686987070397
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	1/41	254/9376	0.900326483579796	GNAS	-0.106726436741417
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	1/41	300/9376	0.762276422764228	NR4A1	-0.277335871360941
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1/41	370/9376	0.618061964403428	GABRP	-0.496761816188156