category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	56/283	268/9376	6.92284162227731	COX6C/NDUFS5/CALM1/NDUFA4/TXN/COX4I1/NDUFB10/COX6B1/UQCRH/NDUFA2/PSMA7/COX5B/NDUFB7/UQCR10/NDUFB1/PSMB1/COX7B/NDUFS6/MT-CO2/SEM1/UBE2L3/COX5A/PSMA4/PSMD14/COX7C/PSMC3/UCHL1/COX6A1/UQCRQ/NDUFA1/NDUFS3/PSMB3/PSMB5/PARK7/NDUFB2/CYCS/COX7A1/NDUFS8/PSMB6/PSMD7/NDUFB11/VDAC2/NDUFA13/NDUFB3/NDUFB9/NDUFC2/PSMC4/MT-ND6/NDUFA11/GNAS/SLC25A5/NDUFA6/CYC1/TXN2/SLC39A6/GNAI2	17.3544664499319
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	56/283	308/9376	6.02377128172181	POLR2J3/COX6C/NDUFS5/NDUFA4/POLR2L/COX4I1/NDUFB10/AP2S1/COX6B1/UQCRH/NDUFA2/PSMA7/COX5B/NDUFB7/UQCR10/NDUFB1/PSMB1/COX7B/NDUFS6/MT-CO2/SEM1/POLR2E/COX5A/PSMA4/PSMD14/COX7C/PSMC3/POLR2I/COX6A1/UQCRQ/NDUFA1/NDUFS3/CREB3L1/PSMB3/PSMB5/NDUFB2/CYCS/COX7A1/NDUFS8/GPX7/PSMB6/CLTB/PSMD7/NDUFB11/VDAC2/NDUFA13/NDUFB3/NDUFB9/NDUFC2/PSMC4/POLR2F/MT-ND6/NDUFA11/SLC25A5/NDUFA6/CYC1	15.8152012200805
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	50/283	275/9376	6.02377128172181	COX6C/NDUFS5/NDUFA4/COX4I1/NDUFB10/COX6B1/UQCRH/NDUFA2/PSMA7/COX5B/NDUFB7/UQCR10/NDUFB1/PSMB1/COX7B/CYBA/NDUFS6/MT-CO2/SEM1/COX5A/PSMA4/PSMD14/COX7C/PSMC3/COX6A1/UQCRQ/NDUFA1/NDUFS3/CACNA1D/CREB3L1/PSMB3/PSMB5/NDUFB2/CYCS/COX7A1/NDUFS8/PSMB6/PSMD7/NDUFB11/VDAC2/NDUFA13/NDUFB3/NDUFB9/NDUFC2/PSMC4/MT-ND6/NDUFA11/SLC25A5/NDUFA6/CYC1	14.9168426674327
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	35/283	138/9376	8.40272443283659	COX6C/NDUFS5/NDUFA4/COX4I1/NDUFB10/COX6B1/UQCRH/NDUFA2/COX5B/NDUFB7/UQCR10/NDUFB1/COX7B/NDUFS6/MT-CO2/COX5A/COX7C/COX6A1/UQCRQ/NDUFA1/NDUFS3/NDUFB2/CYCS/COX7A1/NDUFS8/NDUFB11/NDUFA13/NDUFB3/NDUFB9/NDUFC2/MT-ND6/NDUFA11/NDUFA6/ATP6V0D1/CYC1	15.4549430009861
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	54/283	388/9376	4.61097956358603	GAPDH/COX6C/NDUFS5/CALM1/NDUFA4/APOE/COX4I1/BACE2/NDUFB10/COX6B1/UQCRH/NDUFA2/PSMA7/COX5B/NDUFB7/UQCR10/NDUFB1/PSMB1/COX7B/NDUFS6/MT-CO2/SEM1/COX5A/PSMA4/PSMD14/COX7C/PSMC3/COX6A1/UQCRQ/NDUFA1/NDUFS3/CACNA1D/PSMB3/PSMB5/NDUFB2/CYCS/COX7A1/NDUFS8/WNT4/PSMB6/PSMD7/NDUFB11/VDAC2/NDUFA13/NDUFB3/NDUFB9/NDUFC2/PSMC4/MT-ND6/NDUFA11/SLC25A5/NDUFA6/CYC1/SLC39A6	12.815472465869
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	38/283	205/9376	6.14130828234077	GAPDH/COX6C/NDUFS5/NDUFA4/COX4I1/NDUFB10/COX6B1/UQCRH/NDUFA2/COX5B/NDUFB7/UQCR10/NDUFB1/COX7B/CYBA/NDUFS6/MT-CO2/COX5A/COX7C/COX6A1/UQCRQ/NDUFA1/NDUFS3/NDUFB2/COX7A1/NDUFS8/CTSD/NDUFB11/VDAC2/NDUFA13/NDUFB3/NDUFB9/NDUFC2/MT-ND6/NDUFA11/SLC25A5/NDUFA6/CYC1	13.1300835605205
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	50/283	368/9376	4.50145951759103	COX6C/NDUFS5/NDUFA4/COX4I1/NDUFB10/COX6B1/UQCRH/NDUFA2/PSMA7/COX5B/NDUFB7/UQCR10/NDUFB1/PSMB1/COX7B/NDUFS6/CHCHD10/MT-CO2/SEM1/SIGMAR1/COX5A/PSMA4/PSMD14/COX7C/PSMC3/COX6A1/UQCRQ/NDUFA1/NDUFS3/PSMB3/PSMB5/NDUFB2/CYCS/COX7A1/NDUFS8/GPX7/PSMB6/PSMD7/TOMM40/NDUFB11/NDUFA13/NDUFB3/NDUFB9/NDUFC2/PSMC4/MT-ND6/NDUFA11/NDUFA6/NXT1/CYC1	12.0888249966932
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	39/283	227/9376	5.69206581466665	COX6C/NDUFS5/NDUFA4/COX4I1/NDUFB10/COX6B1/UQCRH/NDUFA2/COX5B/NDUFB7/UQCR10/NDUFB1/COX7B/CYBA/NDUFS6/MT-CO2/COX5A/COX7C/COX6A1/UQCRQ/NDUFA1/NDUFS3/NDUFB2/COX7A1/NDUFS8/CBR1/NDUFB11/VDAC2/NDUFA13/NDUFB3/NQO1/NDUFB9/NDUFC2/MT-ND6/NDUFA11/GSTM3/SLC25A5/NDUFA6/CYC1	12.6245373187246
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	33/283	157/9376	6.96378654542999	COX6C/NDUFS5/NDUFA4/COX4I1/NDUFB10/COX6B1/UQCRH/NDUFA2/COX5B/NDUFB7/UQCR10/NDUFB1/COX7B/NDUFS6/MT-CO2/COX5A/COX7C/COX6A1/UQCRQ/NDUFA1/NDUFS3/NDUFB2/CYCS/COX7A1/NDUFS8/NDUFB11/NDUFA13/NDUFB3/NDUFB9/NDUFC2/NDUFA11/NDUFA6/CYC1	13.2939876205098
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	56/283	480/9376	3.86525323910483	COX6C/NDUFS5/CALM1/NDUFA4/COX4I1/NDUFB10/COX6B1/UQCRH/NDUFA2/PSMA7/COX5B/NDUFB7/UQCR10/NDUFB1/PSMB1/COX7B/NDUFS6/MT-CO2/SEM1/SIGMAR1/UBE2L3/COX5A/PSMA4/PSMD14/COX7C/PSMC3/UCHL1/COX6A1/UQCRQ/NDUFA1/NDUFS3/CACNA1D/PSMB3/PSMB5/PARK7/NDUFB2/CYCS/COX7A1/NDUFS8/GPX7/WNT4/PSMB6/PSMD7/TOMM40/NDUFB11/VDAC2/NDUFA13/NDUFB3/NDUFB9/NDUFC2/PSMC4/MT-ND6/NDUFA11/SLC25A5/NDUFA6/CYC1	11.3687182661392
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	38/283	235/9376	5.35731148033982	COX6C/NDUFS5/NDUFA4/COX4I1/NDUFB10/COX6B1/UQCRH/NDUFA2/COX5B/NDUFB7/UQCR10/NDUFB1/COX7B/NDUFS6/MT-CO2/COX5A/COX7C/COX6A1/UQCRQ/NDUFA1/NDUFS3/CREB3L1/NDUFB2/COX7A1/SMARCD3/COX14/NDUFS8/NDUFB11/NDUFA13/NDUFB3/NDUFB9/NDUFC2/MT-ND6/NDUFA11/GNAS/NDUFA6/NDUFAF8/CYC1	11.9338601312168
Genetic Information Processing	Translation	hsa03010	Ribosome	34/283	222/9376	5.07407761118008	RPS26/RPL27A/RPL14/MRPL20/RPL19/RPS8/MRPL17/MRPL51/RPL35/MRPS34/RPL26L1/RPL36/MRPS21/MRPS26/RPL41/RPS28/MRPS12/MRPL22/FAU/MRPL15/RPL30/RPL22L1/MRPL55/RPS21/RPS13/RACK1/MRPL11/MRPL41/MRPL47/MRPL27/RPL28/RPL35A/MRPS6/RPL4	10.8374121904561
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	21/283	149/9376	4.66943344321389	NDUFS5/NDUFA4/NDUFB10/NDUFA2/NDUFB7/NDUFB1/NDUFS6/NDUFA1/NDUFS3/CACNA1D/NDUFB2/NDUFS8/NDUFB11/NDUFA13/NDUFB3/NDUFB9/NDUFC2/MT-ND6/NDUFA11/NDUFA6/GNAI2	7.96502510733438
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	12/283	46/9376	8.64280227377477	PSMA7/PSMB1/SEM1/POMP/PSMA4/PSMD14/PSMC3/PSMB3/PSMB5/PSMB6/PSMD7/PSMC4	9.16676248070583
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	15/283	87/9376	5.71219690508103	COX6C/COX4I1/COX6B1/UQCRH/COX5B/UQCR10/COX7B/MT-CO2/COX5A/COX7C/COX6A1/UQCRQ/CACNA1D/COX7A1/CYC1	7.78975565186689
Genetic Information Processing	Transcription	hsa03040	Spliceosome	22/283	243/9376	2.99949104974625	SNRPB/SNRPF/SRSF2/SNU13/SNRPE/BUD31/LSM3/SNRPB2/CWC15/SNRPC/SNRPD3/SNRPD1/SF3B6/SNRPG/SNRPA1/PQBP1/PUF60/LSM7/LSM4/MAGOH/PPIH/SNRPD2	5.57110229403952
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	20/283	238/9376	2.78409597054369	RPS26/RPL27A/F13A1/RPL14/RPL19/RPS8/RPL35/RPL26L1/RPL36/RPL41/RPS28/FAU/RPL30/RPL22L1/RPS21/RPS13/ISG15/RPL28/RPL35A/RPL4	4.91820213993838
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	14/283	144/9376	3.22104436592069	PSMA7/PSMB1/SEM1/PSMA4/PSMD14/PSMC3/PSMB3/PSMB5/CYCS/PSMB6/PSMD7/VDAC2/PSMC4/SLC25A5	4.73822677283064
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	8/283	54/9376	4.90825808140296	LDHB/TST/MDH2/SRM/CISD1/BHMT2/MPST/ADI1	5.08101907835641
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	8/283	63/9376	4.20707835548825	POLR2J3/POLR2L/RBX1/CETN2/POLR2E/POLR2I/POLE3/POLR2F	4.50567958684449
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	5/283	31/9376	5.34366807249516	SEC61B/SEC11A/SRP14/SEC61G/SRPRB	4.27339546803497
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	8/283	82/9376	3.23226751702146	GSTP1/NME4/CES1/NME1/NME3/TK1/GSTM3/ITPA	3.58160008909717
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	5/283	34/9376	4.87216794845147	POLR2J3/POLR2L/POLR2E/POLR2I/POLR2F	3.99023959010871
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	7/283	67/9376	3.46142081113865	GAPDH/TPI1/LDHB/PGAM1/ALDH2/PGM1/PKM	3.56694994413898
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	7/283	75/9376	3.09220259128386	GAPDH/TPI1/PGAM1/ASS1/IDH3B/IDH3G/PKM	3.20918538405052
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	9/283	116/9376	2.57048860728646	GAPDH/TPI1/GCSH/ECHS1/PGAM1/MDH2/IDH3B/IDH3G/PKM	3.00250370482938
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	7/283	85/9376	2.72841405113282	NME4/NME1/DGUOK/NME3/TK1/APRT/ITPA	2.82391279700254
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	4/283	36/9376	3.68119356105222	SSBP1/FEN1/RNASEH2A/POLE3	2.8433560122506
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	5/283	59/9376	2.80769000419237	GSTP1/GPX4/GPX7/SRM/GSTM3	2.45718115017651
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/283	10/9376	6.62614840989399	TST/MPST	3.14021488412858
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	8/283	128/9376	2.07067137809187	NME4/NME1/DGUOK/NUDT5/NME3/APRT/PGM1/ITPA	2.15160491497193
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	5/283	63/9376	2.62942397218016	GPX4/PTGES2/CBR1/PTGR1/CBR3	2.28920578669475
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	7/283	107/9376	2.16743172286252	CALM1/LDHB/PGAM1/CREB3L1/GNAS/PKM/PYGL	2.14255608183659
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	4/283	47/9376	2.81963762123149	LDHB/ALDH2/MDH2/PKM	2.20618308347422
Organismal Systems	Endocrine system	hsa04924	Renin secretion	5/283	69/9376	2.40077840938188	CALM1/CACNA1D/EDNRA/GNAS/GNAI2	2.06022374378605
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	3/283	30/9376	3.313074204947	MDH2/IDH3B/IDH3G	2.23852817461841
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	8/283	142/9376	1.86652067884338	ELOB/RBX1/UBE2L3/UBE2I/SOCS1/ANAPC11/ANAPC16/UBE2N	1.83549594239757
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	8/283	142/9376	1.86652067884338	GSTP1/CALM1/TXN/CYBA/ASS1/NQO1/GSTM3/TXN2	1.83549594239757
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	4/283	51/9376	2.59848957250745	SEC61B/GNAS/ATP6V0D1/SEC61G	2.01927624303391
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	4/283	52/9376	2.54851861919	APOE/PLTP/VDAC2/APOC1	1.97534169786689
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	4/283	59/9376	2.2461520033539	NME4/NME1/NME3/TK1	1.69388623369852
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	6/283	108/9376	1.84059678052611	SAP18/UBE2I/RAN/MAGOH/RNPS1/NXT1	1.55000053450677
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	7/283	134/9376	1.73071040556933	CALM1/MYL9/RAMP1/CACNA1D/EDNRA/GNAS/MYL6B	1.50293420781096
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	6/283	110/9376	1.80713138451654	GAPDH/IGF1/LDHB/ELOB/RBX1/EIF4EBP1	1.50217209410734
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	3/283	41/9376	2.42420063776609	GCSH/PGAM1/GAMT	1.61224561179392
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	7/283	139/9376	1.66845463558482	KRT19/CALM1/KRT10/CREB3L1/CTSD/GNAS/GNAI2	1.40068064698909
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	8/283	166/9376	1.59666226744434	CALM1/MYL9/CACNA1D/CREB3L1/EDNRA/VDAC2/SLC25A5/GNAI2	1.36828971820414
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	3/283	42/9376	2.36648157496214	GPX4/VDAC2/FTH1	1.56574050807201
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	3/283	43/9376	2.31144711973046	ECHS1/ECI1/ALDH2	1.5205462655184
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	4/283	69/9376	1.92062272750551	CALM1/CACNA1D/CREB3L1/GNAS	1.35402486901041
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	6/283	122/9376	1.62938075653131	IGF1/CACNA1D/CREB3L1/SOCS1/GNAS/GNAI2	1.23439424501631
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	3/283	47/9376	2.11472821592361	CACNA1D/SOCS1/PKM	1.3515298342632
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	3/283	49/9376	2.02841277853898	CREB3L1/GNAS/GNAI2	1.27326785907375
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	7/283	154/9376	1.50594282043045	NAPRT/NME4/QPRT/NME1/ALDH2/NME3/NQO1	1.11679767035049
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	5/283	101/9376	1.64013574502327	CALM1/CREB3L1/WNT4/GNAS/GNAI2	1.14104051952455
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	4/283	75/9376	1.76697290930506	IGF1/SIVA1/CDK4/CYCS	1.17644355320014
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	3/283	50/9376	1.9878445229682	ALDH2/SRM/GAMT	1.2355239070662
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	2/283	27/9376	2.45412904070148	ACOT2/FADS1	1.33483476942446
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	5/283	103/9376	1.6082884490034	SAP18/SSU72/MAGOH/RNPS1/NXT1	1.09507360838307
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/283	28/9376	2.36648157496214	ECHS1/ACOT2	1.27746410078224
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/283	52/9376	1.9113889643925	IGF1/ACOT2/GNAS	1.16259798366643
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	4/283	78/9376	1.69901241279333	LSM3/LSM7/LSM4/EXOSC4	1.09361051850784
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	3/283	53/9376	1.87532502166811	AP2S1/CLTB/GNAS	1.12733942764183
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4/283	79/9376	1.67750592655544	GSTP1/CBR1/CBR3/GSTM3	1.06679381521783
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/283	31/9376	2.13746722899806	ECHS1/ALDH2	1.11906508976096
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	2/283	31/9376	2.13746722899806	GCSH/MDH2	1.11906508976096
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	4/283	83/9376	1.59666226744434	POLR2L/POLR2E/POLR2F/IL33	0.963196536420159
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/283	32/9376	2.07067137809187	LDHB/ECHS1	1.07026180713488
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/283	32/9376	2.07067137809187	BOK/CYCS	1.07026180713488
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	7/283	170/9376	1.36420702556641	GSTP1/IGF2/CDK4/SMARCD3/WNT4/NQO1/GSTM3	0.845400606233821
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	2/283	33/9376	2.00792376057394	IDH3B/IDH3G	1.02321462559204
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	5/283	115/9376	1.44046704562913	CREB3L1/WNK2/GNAS/PTHLH/GNAI2	0.838414266923339
Organismal Systems	Nervous system	hsa04730	Long-term depression	3/283	60/9376	1.6565371024735	IGF1/GNAS/GNAI2	0.900006031263315
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	5/283	116/9376	1.42804922627026	MYL9/CYBA/MYL12B/THY1/GNAI2	0.818356390337934
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	8/283	205/9376	1.29290700680858	SEM1/PSMD14/PSMC3/CDK4/CYCS/PSMD7/ISG15/PSMC4	0.748037904684381
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/283	36/9376	1.84059678052611	PGM1/PYGL	0.891437285433962
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/283	12/9376	2.76089517078916	NQO1	1.07675942863272
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	3/283	65/9376	1.529111171514	CACNA1D/CREB3L1/GNAS	0.75514561805769
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/283	38/9376	1.74372326576158	NAPRT/QPRT	0.810403842569758
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/283	38/9376	1.74372326576158	IGF1/HSD11B2	0.810403842569758
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	6/283	154/9376	1.29080813179753	CALM1/MYL9/CACNA1D/GNAS/MYL6B/GNAI2	0.64191808045452
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	6/283	155/9376	1.28248033739884	SEC61B/CYBA/MRC2/THBS2/ATP6V0D1/SEC61G	0.625590754559307
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	6/283	155/9376	1.28248033739884	CACNA1D/CREB3L1/CDK4/WNT4/GNAS/GNAI2	0.625590754559307
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/283	13/9376	2.54851861919	FEN1	0.985611714140271
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	2/283	39/9376	1.69901241279333	GCSH/BHMT2	0.771682714687569
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	4/283	97/9376	1.36621616698845	CALM1/CACNA1D/GNAS/GNAI2	0.639584680634063
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	6/283	157/9376	1.26614300826	CALM1/EIF4EBP1/CACNA1D/CDK4/VDAC2/SLC25A5	0.593264334687646
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	9/283	250/9376	1.19270671378092	AP2S1/CTSC/HYAL2/FUCA2/LAMTOR4/CLTB/CTSD/CD63/ATP6V0D1	0.544818539930007
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	4/283	98/9376	1.35227518569265	CALM1/CACNA1D/CREB3L1/GNAS	0.618433727521532
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	4/283	99/9376	1.33861584038262	IGF1/CALM1/ASIC2/GNAS	0.597511612172901
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	2/283	41/9376	1.61613375851073	SSBP1/SEM1	0.697485257410877
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/283	70/9376	1.41988894497728	GSTP1/CBR1/GSTM3	0.622052724853848
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	3/283	71/9376	1.39989050913253	LDHB/PGAM1/PKM	0.596674314587911
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/283	42/9376	1.57765438330809	ECHS1/ALDH2	0.661887349367221
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	8/283	224/9376	1.18324078748107	RANBP1/RAN/CREB3L1/CDK4/VDAC2/SLC25A5/ANAPC11/ANAPC16	0.489681180375709
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	5/283	133/9376	1.24551661840113	CALM1/CACNA1D/CREB3L1/GNAS/GNAI2	0.503066616078082
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	2/283	44/9376	1.50594282043045	FEN1/POLE3	0.59342477123452
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	2/283	44/9376	1.50594282043045	CREB3L1/GNAS	0.59342477123452
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/283	16/9376	2.07067137809187	MIF	0.75614227627991
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	3/283	75/9376	1.3252296819788	GSTP1/CYCS/GSTM3	0.498862942916674
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	3/283	75/9376	1.3252296819788	CREB3L1/GPX7/GNAS	0.498862942916674
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	3/283	76/9376	1.30779244932118	CALM1/GNAS/GNAI2	0.47527891060559
Human Diseases	Cancer: specific types	hsa05214	Glioma	3/283	76/9376	1.30779244932118	IGF1/CALM1/CDK4	0.47527891060559
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	5/283	138/9376	1.20038920469094	IGF1/CALM1/RBX1/ANAPC11/ANAPC16	0.418359992271753
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	6/283	170/9376	1.16932030762835	MYL9/MYL12B/CACNA1D/RAB13/CDK4/MYL6B	0.393027812942627
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/283	18/9376	1.84059678052611	FUCA2	0.629734830747452
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/283	18/9376	1.84059678052611	CD320	0.629734830747452
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	4/283	110/9376	1.20475425634436	IGF1/ANAPC11/ANAPC16/GNAI2	0.381073188244854
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	2/283	48/9376	1.38044758539458	ECHS1/ALDH2	0.466172276762811
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	3/283	79/9376	1.25812944491658	AP2S1/CLTB/ATP6V0D1	0.406447950592333
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	6/283	174/9376	1.14243938101621	SEC61B/RBX1/SSR4/BCAP31/BAG1/SEC61G	0.334571426346418
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/283	19/9376	1.74372326576158	HYAL2	0.572459957266263
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/283	19/9376	1.74372326576158	GCSH	0.572459957266263
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	2/283	50/9376	1.3252296819788	THBS2/GYPC	0.406773574210805
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	6/283	178/9376	1.11676658593719	SFRP4/RBX1/SFRP1/PRICKLE1/WNT4/CBY1	0.277464318416121
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/283	20/9376	1.6565371024735	EBP	0.518506763540617
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/283	20/9376	1.6565371024735	CYB5R2	0.518506763540617
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	4/283	117/9376	1.13267494186222	BCL7C/RUVBL2/SMARCD3/POLE3	0.254756371878257
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/283	21/9376	1.57765438330809	B4GALT7	0.467499429290379
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/283	21/9376	1.57765438330809	ALDH2	0.467499429290379
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	3/283	86/9376	1.15572355986523	CACNA1D/CREB3L1/GNAS	0.255929855955965
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/283	22/9376	1.50594282043045	ALDH2	0.419120936153558
NA	NA	hsa04081	Hormone signaling	7/283	219/9376	1.05897349016571	IGF1/IGF2/RAMP1/PENK/GNAS/PTHLH/GNAI2	0.155785682638202
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	5/283	154/9376	1.07567344316461	CALM1/CACNA1D/CREB3L1/GNAS/GNAI2	0.167038490558545
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	3/283	88/9376	1.12945711532284	F13A1/F3/CLU	0.215244180602823
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/283	23/9376	1.44046704562913	ASS1	0.373101618209574
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/283	23/9376	1.44046704562913	SSBP1	0.373101618209574
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	3/283	89/9376	1.11676658593719	GJA1/GNAS/GNAI2	0.195254532155962
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	3/283	90/9376	1.10435806831567	IGF1/EIF4EBP1/CREB3L1	0.175492357076329
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	2/283	57/9376	1.16248217717438	ECHS1/FADS1	0.217061980944682
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/283	24/9376	1.38044758539458	B4GALT7	0.329210337722611
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	7/283	226/9376	1.02617342631102	CALM1/MYL9/CACNA1D/CREB3L1/EDNRA/GNAS/GNAI2	0.0702634567475909
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	7/283	227/9376	1.02165283852991	CALM1/EIF4EBP1/CREB3L1/CDK4/CYCS/GNAS/GNAI2	0.0582594274834565
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2/283	59/9376	1.12307600167695	GNAS/GNAI2	0.167296400742561
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	3/283	93/9376	1.06873361449903	CALM1/CACNA1D/GNAS	0.117514577161188
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	10/283	333/9376	0.994917178662762	EIF4EBP1/CREB3L1/CDK4/WNT4/THBS2/BCAP31/ISG15/GNAS/ATP6V0D1/PKM	-0.0166608040314778
Organismal Systems	Digestive system	hsa04978	Mineral absorption	2/283	61/9376	1.08625383768754	MT1X/FTH1	0.119227702576682
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/283	27/9376	1.22706452035074	ECHS1	0.208436533610966
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	2/283	63/9376	1.05176958887206	ECHS1/ALDH2	0.0727319865450159
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	5/283	168/9376	0.986033989567558	VDAC2/FTH1/SLC25A5/IL33/PYGL	-0.0322232698367506
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/283	28/9376	1.18324078748107	CBR1	0.171303830285908
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/283	28/9376	1.18324078748107	ATP6V0D1	0.171303830285908
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	3/283	99/9376	1.00396188028697	IGF1/CDK4/GNAS	0.00699101812492807
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/283	29/9376	1.14243938101621	CALM1	0.135524625471489
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	5/283	173/9376	0.957535897383525	CDK4/CYCS/SLC25A5/IL33/NXT1	-0.0994501749930283
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	4/283	138/9376	0.960311363752753	CALM1/EIF4EBP1/SOCS1/PYGL	-0.0828594413520594
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/283	31/9376	1.06873361449903	PGM1	0.0676216303362921
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/283	31/9376	1.06873361449903	ALDH2	0.0676216303362921
NA	NA	hsa04981	Folate transport and metabolism	1/283	31/9376	1.06873361449903	BHMT2	0.0676216303362921
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	3/283	105/9376	0.946592629984856	IGF1/CACNA1D/GNAS	-0.0970862689980381
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	3/283	106/9376	0.937662510834056	GSTP1/IGF1/CREB3L1	-0.113864313406672
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/283	32/9376	1.03533568904594	PGM1	0.0353221718526362
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	7/283	248/9376	0.935141912686652	GAPDH/TXN/MYL9/MYL12B/DYNLT1/CYCS/TXN2	-0.182611204955265
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	2/283	70/9376	0.946592629984856	ELOB/RBX1	-0.0791213973185106
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	4/283	143/9376	0.926734043341817	SNRPB/SNRPD3/SNRPD1/SSB	-0.155748576523907
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	5/283	181/9376	0.915213868769888	CALM1/MRC2/CYCS/CTSD/ATP6V0D1	-0.203195225952395
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	6/283	217/9376	0.916057383856312	EIF4EBP1/CACNA1D/CREB3L1/GNAS/GSTM3/GNAI2	-0.220705724686521
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/283	34/9376	0.974433589690293	RBX1	-0.026345991174157
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/283	73/9376	0.907691562999177	GSTP1/GSTM3	-0.139674323767024
Human Diseases	Cancer: specific types	hsa05218	Melanoma	2/283	73/9376	0.907691562999177	IGF1/CDK4	-0.139674323767024
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	5/283	183/9376	0.905211531406283	SNU13/RAN/RPP25/NXT1/POP5	-0.228442909116411
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/283	35/9376	0.946592629984856	TPI1	-0.0558423631675287
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	3/283	112/9376	0.887430590610803	SOCS1/CYCS/GNAI2	-0.211424535963766
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/283	36/9376	0.920298390263055	GALNT17	-0.0845220779743551
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	5/283	187/9376	0.885848717900266	TXN/CYBA/TXNIP/VDAC2/TXN2	-0.278158753561787
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/283	37/9376	0.895425460796486	ASS1	-0.112435095817339
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/283	37/9376	0.895425460796486	MIF	-0.112435095817339
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/283	37/9376	0.895425460796486	PGM1	-0.112435095817339
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	3/283	115/9376	0.864280227377477	CACNA1D/CREB3L1/GNAI2	-0.258338040948754
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	3/283	115/9376	0.864280227377477	CACNA1D/GNAS/GNAI2	-0.258338040948754
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	3/283	116/9376	0.856829535762154	CACNA1D/GNAS/GNAI2	-0.273717266907792
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	2/283	78/9376	0.849506206396666	TPI1/ITPK1	-0.235448745462284
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	2/283	78/9376	0.849506206396666	CALM1/GNAI2	-0.235448745462284
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	2/283	78/9376	0.849506206396666	CYBA/MARCKSL1	-0.235448745462284
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/283	38/9376	0.871861632880789	PGM1	-0.139626968624797
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	2/283	80/9376	0.828268551236749	IGF1/EIF4EBP1	-0.272127248267858
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	4/283	158/9376	0.838752963277721	RBX1/CDK4/ANAPC11/ANAPC16	-0.360601222101771
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	4/283	158/9376	0.838752963277721	IGF1/EIF4EBP1/LAMTOR4/WNT4	-0.360601222101771
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	1/283	41/9376	0.808066879255365	CDK4	-0.217275096972167
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	3/283	122/9376	0.814690378265655	IGF1/EIF4EBP1/CREB3L1	-0.363444748256529
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	2/283	86/9376	0.770482373243488	GJA1/CACNA1D	-0.377209544952511
Organismal Systems	Immune system	hsa04611	Platelet activation	3/283	126/9376	0.788827191654047	MYL12B/GNAS/GNAI2	-0.420995702074808
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	1/283	44/9376	0.752971410215227	PTPRN2	-0.289741999415458
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	5/283	204/9376	0.812027991408578	IGF1/LUM/IGF2/WNT4/CD63	-0.478852217854963
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	5/283	205/9376	0.808066879255365	RANBP1/CREB3L1/CDK4/ATP6V0D1/PKM	-0.490166660899228
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	2/283	89/9376	0.74451105729146	FREM1/THBS2	-0.427223024285487
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	2/283	89/9376	0.74451105729146	CACNA1D/GNAI2	-0.427223024285487
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/283	46/9376	0.720233522814564	FTH1	-0.335551379527717
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	3/283	130/9376	0.764555585756999	CREB3L1/GNAS/GNAI2	-0.47687920364821
Human Diseases	Substance dependence	hsa05032	Morphine addiction	2/283	91/9376	0.728148176911428	GNAS/GNAI2	-0.45971349456747
NA	NA	hsa03272	Virion - Hepatitis viruses	1/283	48/9376	0.690223792697291	CD63	-0.379576807395106
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/283	48/9376	0.690223792697291	CACNA1D	-0.379576807395106
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	2/283	93/9376	0.712489076332687	MYL9/MYL12B	-0.491560423094918
Organismal Systems	Digestive system	hsa04970	Salivary secretion	2/283	93/9376	0.712489076332687	CALM1/GNAS	-0.491560423094918
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	2/283	93/9376	0.712489076332687	CDK4/CYCS	-0.491560423094918
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	1/283	49/9376	0.676137592846326	GALNT17	-0.400970896507973
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	5/283	214/9376	0.774082758165186	CALM1/ELOB/RBX1/CYCS/GNAI2	-0.589775028940641
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	6/283	253/9376	0.785709297615888	MYL9/RBX1/MYL12B/CYCS/CAPNS1/UBE2N	-0.609564984821581
Human Diseases	Infectious disease: viral	hsa05162	Measles	3/283	136/9376	0.73082519226772	CDK4/CYCS/RACK1	-0.557818791567187
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	6/283	254/9376	0.782615953924487	CALM1/CACNA1D/EDNRA/VDAC2/GNAS/SLC25A5	-0.619619037245787
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	3/283	137/9376	0.725490701813211	CTSC/CYCS/CTSD	-0.57099212673654
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/283	51/9376	0.649622393126862	PAFAH1B3	-0.442611068485219
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	2/283	98/9376	0.676137592846326	CALM1/ITPK1	-0.568553914083766
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	2/283	98/9376	0.676137592846326	MARCKSL1/BIN1	-0.568553914083766
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	2/283	99/9376	0.669307920191312	KRT19/KRT10	-0.583529575923045
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	2/283	99/9376	0.669307920191312	IGF1/CACNA1D	-0.583529575923045
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/283	54/9376	0.61353226017537	CENPX	-0.502436102815742
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	4/283	184/9376	0.720233522814564	MYL9/MYL12B/WNT4/GNAI2	-0.676121643293771
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	2/283	101/9376	0.656054298009306	F3/CDK4	-0.613082436871939
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	1/283	56/9376	0.591620393740535	CYCS	-0.540723648496557
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	2/283	103/9376	0.643315379601358	GNAS/GNAI2	-0.642122852989607
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	3/283	148/9376	0.671569095597364	IGF1/CDK4/WNT4	-0.710470976812024
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	2/283	105/9376	0.631061753323237	TOMM40/FIS1	-0.670672190942339
Human Diseases	Substance dependence	hsa05034	Alcoholism	4/283	191/9376	0.693837529831832	CALM1/CREB3L1/GNAS/GNAI2	-0.754144063862574
Cellular Processes	Cell motility	hsa04814	Motor proteins	4/283	194/9376	0.683108083494226	MYL9/MYL12B/DYNLT1/MYL6B	-0.786807773884567
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	2/283	109/9376	0.607903523843486	CREB3L1/PYGL	-0.72637663685726
NA	NA	hsa04518	Integrin signaling	3/283	154/9376	0.645404065898766	IGF1/FREM1/THBS2	-0.782720689233404
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	1/283	62/9376	0.534366807249516	IGF1	-0.648928607160005
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	1/283	63/9376	0.525884794436031	WNT4	-0.666092613504896
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/283	65/9376	0.509703723837999	ALDH2	-0.699749134826087
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	1/283	65/9376	0.509703723837999	CACNA1D	-0.699749134826087
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	4/283	203/9376	0.652822503437832	IGF1/MYL9/MYL12B/THBS2	-0.882204258486556
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/283	66/9376	0.501980940143484	HSD11B2	-0.716256129925217
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/283	66/9376	0.501980940143484	MAF	-0.716256129925217
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	1/283	67/9376	0.494488687305522	CALM1	-0.732558017067819
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/283	68/9376	0.487216794845147	ALDH1A2	-0.748661193137278
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	1/283	68/9376	0.487216794845147	EIF4EBP1	-0.748661193137278
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	5/283	250/9376	0.662614840989399	AP2S1/PSD/SNF8/CLTB/BIN1	-0.953852027880979
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	2/283	120/9376	0.552179034157833	CALM1/BEX3	-0.870980902841786
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	1/283	70/9376	0.473296314992428	CYCS	-0.780295519490869
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	1/283	71/9376	0.466630169710845	SOCS1	-0.795838037266789
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	1/283	71/9376	0.466630169710845	ATP6V0D1	-0.795838037266789
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	4/283	212/9376	0.625108340556037	IGF1/CALM1/GNAS/GNAI2	-0.973994330716768
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/283	72/9376	0.460149195131527	ISG15	-0.811204611728247
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	1/283	73/9376	0.453845781499588	RAN	-0.8264003120416
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	1/283	73/9376	0.453845781499588	CDK4	-0.8264003120416
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	2/283	125/9376	0.530091872791519	CTSD/GNAI2	-0.933037035580553
NA	NA	hsa04382	Cornified envelope formation	4/283	217/9376	0.610704922570875	KRT19/S100A13/S100A11/KRT10	-1.02355223279935
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	1/283	76/9376	0.435930816440394	PLTP	-0.87100962892251
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	1/283	77/9376	0.430269377265844	CDK4	-0.88556830060281
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	1/283	77/9376	0.430269377265844	CDK4	-0.88556830060281
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	1/283	78/9376	0.424753103198333	CLTB	-0.899978377447348
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	3/283	180/9376	0.552179034157833	SRSF2/EIF4EBP1/CYCS	-1.0702037143811
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	1/283	83/9376	0.399165566861084	PRDX5	-0.969931695932765
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	2/283	140/9376	0.473296314992428	CALM1/GNAI2	-1.10767836438717
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	1/283	86/9376	0.385241186621744	EIF4EBP1	-1.01034894586099
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/283	86/9376	0.385241186621744	ASIC2	-1.01034894586099
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	1/283	87/9376	0.380813127005402	CYCS	-1.0235808351452
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	2/283	142/9376	0.466630169710845	CYBA/SOCS1	-1.12980357329704
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	2/283	144/9376	0.460149195131527	IGF1/WNT4	-1.15168142348279
Organismal Systems	Digestive system	hsa04976	Bile secretion	1/283	90/9376	0.368119356105222	GNAS	-1.06259367749678
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	3/283	195/9376	0.509703723837999	CYBA/VDAC2/SLC25A5	-1.22055166408214
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	3/283	196/9376	0.507103194634744	CALM1/CDK4/CYCS	-1.2302346611248
NA	NA	hsa04082	Neuroactive ligand signaling	3/283	199/9376	0.499458422856331	PENK/GNAS/GNAI2	-1.25904597927726
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	1/283	93/9376	0.356244538166344	MAF	-1.10063542335102
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	1/283	95/9376	0.348744653152315	ATP6V0D1	-1.12548828439206
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	2/283	156/9376	0.424753103198333	CDK4/CYCS	-1.27813398764805
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	1/283	99/9376	0.334653960095656	EIF4EBP1	-1.17405016997102
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	1/283	102/9376	0.324811196563431	GNAS	-1.20953107977246
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	1/283	103/9376	0.321657689800679	GNAS	-1.22118834011383
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	1/283	104/9376	0.31856482739875	PEMT	-1.23276349297906
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	2/283	163/9376	0.406512172386135	CREB3L1/CYCS	-1.34843601383122
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	1/283	105/9376	0.315530876661619	UBE2I	-1.24425811288664
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	1/283	105/9376	0.315530876661619	CALM1	-1.24425811288664
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	3/283	216/9376	0.460149195131527	CALM1/CYBA/CYCS	-1.41604857846295
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	6/283	362/9376	0.549128321261933	IGF1/IGF2/EIF4EBP1/CREB3L1/CDK4/THBS2	-1.54338304519564
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	1/283	110/9376	0.301188564086091	RBX1	-1.30057517054888
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	3/283	233/9376	0.426576077890171	PDLIM2/MYL9/THBS2	-1.56363242548787
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	1/283	119/9376	0.278409597054369	CREB3L1	-1.3975081772765
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	1/283	122/9376	0.271563459421885	CDK4	-1.42867074377176
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	1/283	122/9376	0.271563459421885	WNT4	-1.42867074377176
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	3/283	238/9376	0.417614395581554	IGF1/CALM1/IGF2	-1.60545742673654
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	1/283	133/9376	0.249103323680225	IGF1	-1.53859666380422
NA	NA	hsa04519	Cadherin signaling	6/283	404/9376	0.49204072350698	KRT19/KRT10/PRICKLE1/GJA1/CDH13/WNT4	-1.8411967789647
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	2/283	200/9376	0.3313074204947	GAPDH/CYCS	-1.68632026721023
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	2/283	201/9376	0.329659124870348	IGF1/MAF	-1.69479024145437
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	1/283	144/9376	0.230074597565764	ALDH2	-1.64250710650891
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	1/283	149/9376	0.222353973486376	GNAS	-1.6879908633456
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	1/283	150/9376	0.220871613663133	WNT4	-1.69696620048466
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	1/283	157/9376	0.21102383471	WNT4	-1.75872145898312
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	2/283	232/9376	0.285609845254051	MYL9/MYL12B	-1.94373298616422
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	1/283	168/9376	0.197206797913512	SOCS1	-1.8522556673631
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	1/283	169/9376	0.196039893783846	CTSD	-1.86056154305113
NA	NA	hsa04517	IgSF CAM signaling	3/283	299/9376	0.33241547206826	MYL9/MYL12B/MYL6B	-2.06964543401529
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	3/283	300/9376	0.3313074204947	IGF1/IGF2/CACNA1D	-2.07665880596796
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	1/283	193/9376	0.171661875903989	GNAI2	-2.05125320627478
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	3/283	370/9376	0.268627638238946	PGRMC1/PENK/EDNRA	-2.53220403012758
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	2/283	323/9376	0.205143913619009	UBE2I/SOCS1	-2.56459484791365
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	1/283	298/9376	0.111176986743188	IL33	-2.75076565969523
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/283	449/9376	0.0737878442081736	CALM1	-3.54818405571569