category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	29/55	222/9376	22.2689598689599	RPS8/RPL24/RPS24/RPL41/RPS12/RPS27/RPL30/RPL23A/RPL32/RPL13A/RPS25/RPS20/RPS19/RPL26/RPS26/RPL35A/RPL34/RPS15A/RPL38/RPL11/RPS18/RPLP2/RPL37/RPL7A/RPS13/RPL13/RPL3/RPS27A/RPL9	24.6350253749629
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	29/55	238/9376	20.7718869365928	RPS8/RPL24/RPS24/RPL41/RPS12/RPS27/RPL30/RPL23A/RPL32/RPL13A/RPS25/RPS20/RPS19/RPL26/RPS26/RPL35A/RPL34/RPS15A/RPL38/RPL11/RPS18/RPLP2/RPL37/RPL7A/RPS13/RPL13/RPL3/RPS27A/RPL9	23.7326781148366
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	3/55	110/9376	4.64925619834711	IGF1/GAPDH/ANGPT1	2.95726523585801
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	4/55	205/9376	3.32629711751663	GAPDH/MT-CO1/MT-ND5/MT-ATP8	2.58683956846755
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	2/55	52/9376	6.55664335664336	APOE/LRPAP1	3.08637570447679
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	3/55	138/9376	3.70592885375494	MT-CO1/MT-ND5/MT-ATP8	2.45981625350365
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	2/55	75/9376	4.54593939393939	GAPDH/MAT2A	2.36827890702807
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	4/55	268/9376	2.54436906377205	MT-CO1/MT-ND5/MT-ATP8/RPS27A	1.97034696114001
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	5/55	388/9376	2.19681349578257	GAPDH/MT-CO1/MT-ND5/APOE/MT-ATP8	1.84946679179398
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	4/55	308/9376	2.21393152302243	POLR2J3/MT-CO1/MT-ND5/MT-ATP8	1.66398543548503
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	3/55	200/9376	2.55709090909091	GAPDH/IL1R1/TMED10	1.70977118456177
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	2/55	99/9376	3.44389348025712	IGF1/IL1R1	1.87772427469763
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	2/55	100/9376	3.40945454545455	IL1R1/CD24	1.86069031321927
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	3/55	224/9376	2.28311688311688	IL1R1/XPO1/HLA-B	1.49302799769392
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	3/55	227/9376	2.25294353223869	MT-CO1/MT-ND5/MT-ATP8	1.46788942715474
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/55	29/9376	5.87836990595611	LIMD1	2.02103267252497
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	3/55	235/9376	2.17624758220503	MT-CO1/MT-ND5/MT-ATP8	1.40272180922409
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/55	34/9376	5.01390374331551	POLR2J3	1.80103523589128
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/55	37/9376	4.60737100737101	HBB	1.6887960861334
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/55	38/9376	4.48612440191388	IGF1	1.65403034639976
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/55	39/9376	4.37109557109557	MAT2A	1.62044919008583
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/55	39/9376	4.37109557109557	HLA-B	1.62044919008583
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	3/55	275/9376	1.85970247933884	MT-CO1/MT-ND5/MT-ATP8	1.11149035364428
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	1/55	42/9376	4.05887445887446	FTH1	1.5261180504823
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	1/55	44/9376	3.87438016528926	HLA-B	1.46797584502877
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/55	45/9376	3.78828282828283	HLA-B	1.44017316796771
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/55	46/9376	3.70592885375494	FTH1	1.41315629208803
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	1/55	50/9376	3.40945454545455	HBB	1.31217501241418
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	3/55	300/9376	1.70472727272727	IGF1/IL1R1/ANGPT1	0.952950169410489
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/55	52/9376	3.27832167832168	IGF1	1.26546841746607
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	1/55	54/9376	3.15690235690236	MAT2A	1.22097998438987
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/55	54/9376	3.15690235690236	REV3L	1.22097998438987
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	1/55	54/9376	3.15690235690236	HLA-B	1.22097998438987
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	2/55	178/9376	1.91542390194076	SFRP4/APCDD1	0.947155477697277
Organismal Systems	Nervous system	hsa04730	Long-term depression	1/55	60/9376	2.84121212121212	IGF1	1.09900695169539
Organismal Systems	Digestive system	hsa04978	Mineral absorption	1/55	61/9376	2.7946348733234	FTH1	1.08015310786778
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	1/55	62/9376	2.74956011730205	IGF1	1.06167679947133
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	4/55	480/9376	1.42060606060606	MT-CO1/MT-ND5/MT-ATP8/RPS27A	0.726665408219185
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/55	63/9376	2.70591630591631	PTGDS	1.04356360076411
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/55	63/9376	2.70591630591631	POLR2J3	1.04356360076411
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	2/55	196/9376	1.73951762523191	HLA-B/RPS27A	0.803694420288811
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	1/55	67/9376	2.54436906377205	GAPDH	0.97447950273499
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	2/55	204/9376	1.67130124777184	IGF1/HOXD10	0.744622652701325
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	1/55	70/9376	2.43532467532468	HLA-B	0.925877170880882
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	1/55	73/9376	2.33524283935243	XPO1	0.879722918124225
Human Diseases	Cancer: specific types	hsa05218	Melanoma	1/55	73/9376	2.33524283935243	IGF1	0.879722918124225
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	2/55	212/9376	1.6082332761578	IGF1/ANGPT1	0.688067897180257
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	1/55	75/9376	2.2729696969697	REV3L	0.850197069857413
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	1/55	75/9376	2.2729696969697	IGF1	0.850197069857413
Human Diseases	Cancer: specific types	hsa05214	Glioma	1/55	76/9376	2.24306220095694	IGF1	0.835783727815641
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	3/55	368/9376	1.3897233201581	MT-CO1/MT-ND5/MT-ATP8	0.585870786706822
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	1/55	80/9376	2.13090909090909	IGF1	0.780297759893116
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	1/55	82/9376	2.07893569844789	HLA-B	0.753766589920161
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	2/55	227/9376	1.50196235482579	IL1R1/HLA-B	0.588075371730405
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	1/55	87/9376	1.9594566353187	MT-CO1	0.690615346011683
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	2/55	238/9376	1.43254392666157	IGF1/ANGPT1	0.519193024667154
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	1/55	90/9376	1.89414141414141	IGF1	0.6547098195677
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	1/55	95/9376	1.79444976076555	ANGPT1	0.597814691629555
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	2/55	253/9376	1.34761049227452	IL1R1/RPS27A	0.430546466016593
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	1/55	99/9376	1.72194674012856	IGF1	0.554695583064279
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	1/55	99/9376	1.72194674012856	IGF1	0.554695583064279
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	1/55	103/9376	1.65507502206531	IL1R1	0.513493855974176
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	1/55	105/9376	1.62354978354978	IL1R1	0.493558028474035
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	1/55	105/9376	1.62354978354978	RPS27A	0.493558028474035
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	1/55	105/9376	1.62354978354978	IGF1	0.493558028474035
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	1/55	106/9376	1.6082332761578	IGF1	0.483747764455551
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	1/55	108/9376	1.57845117845118	XPO1	0.46443111105724
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	1/55	109/9376	1.56396997497915	IL1R1	0.454920365864259
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	1/55	110/9376	1.5497520661157	IGF1	0.445505216707298
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	1/55	116/9376	1.46959247648903	GAPDH	0.390913222501942
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	1/55	122/9376	1.3973174366617	IGF1	0.339303642270346
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	1/55	122/9376	1.3973174366617	IGF1	0.339303642270346
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	1/55	133/9376	1.28174982911825	IGF1	0.251373061355464
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	1/55	133/9376	1.28174982911825	HLA-B	0.251373061355464
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	1/55	134/9376	1.27218453188602	CALCRL	0.243763449449861
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	1/55	138/9376	1.23530961791831	IGF1	0.213907480219959
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	1/55	139/9376	1.22642249836494	FKBP5	0.206584263130237
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	1/55	142/9376	1.20051216389245	RPS27A	0.184937801228452
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	1/55	142/9376	1.20051216389245	IL1R1	0.184937801228452
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	1/55	142/9376	1.20051216389245	IL1R1	0.184937801228452
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	1/55	144/9376	1.18383838383838	IGF1	0.170767519660639
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	1/55	148/9376	1.15184275184275	IGF1	0.143023321481149
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	1/55	149/9376	1.14411226357535	MT-ND5	0.136207036065971
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	1/55	154/9376	1.10696576151122	MAT2A	0.102808333119291
NA	NA	hsa04518	Integrin signaling	1/55	154/9376	1.10696576151122	IGF1	0.102808333119291
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	1/55	155/9376	1.09982404692082	HLA-B	0.0962604171651613
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	1/55	157/9376	1.08581354950782	CD24	0.0832912756819092
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	1/55	157/9376	1.08581354950782	HLA-B	0.0832912756819092
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	1/55	157/9376	1.08581354950782	LIMD1	0.0832912756819092
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	1/55	157/9376	1.08581354950782	MT-CO1	0.0832912756819092
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	1/55	158/9376	1.0789413118527	IGF1	0.076868828046282
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	1/55	160/9376	1.06545454545455	HLA-B	0.0641452199320593
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	1/55	168/9376	1.01471861471861	FTH1	0.0147868154179418
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	2/55	362/9376	0.941838272225013	IGF1/ANGPT1	-0.0866899069356337
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	1/55	169/9376	1.00871436256052	RPS27A	0.00878123570227137
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	1/55	173/9376	0.985391487125591	XPO1	-0.0148970431986743
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	1/55	180/9376	0.947070707070707	HLA-B	-0.0550767864417067
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	1/55	183/9376	0.931544957774466	XPO1	-0.0718353292171844
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	1/55	184/9376	0.926482213438735	SEMA5A	-0.0773627778829979
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	1/55	201/9376	0.84812302125735	IGF1	-0.167194763159089
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	1/55	203/9376	0.839767129422302	IGF1	-0.177288132096111
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	1/55	205/9376	0.831574279379157	HLA-B	-0.187289196710507
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	1/55	205/9376	0.831574279379157	HLA-B	-0.187289196710507
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	1/55	214/9376	0.79660152931181	HLA-B	-0.23120389976191
NA	NA	hsa04081	Hormone signaling	1/55	219/9376	0.778414279784143	IGF1	-0.254872482306826
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	1/55	248/9376	0.687390029325513	GAPDH	-0.383245072201241
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	1/55	250/9376	0.681890909090909	HLA-B	-0.39159900677059
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	1/55	298/9376	0.572056131787675	IL1R1	-0.576680916201159
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	1/55	323/9376	0.527779341401632	HOXD10	-0.663415650280802
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	1/55	333/9376	0.511930111930112	HLA-B	-0.696600199610841
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1/55	370/9376	0.460737100737101	CALCRL	-0.81296371464892
NA	NA	hsa04519	Cadherin signaling	1/55	404/9376	0.421962196219622	LIMD1	-0.91230072784416