category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	69/1031	333/9376	1.88435962635769	FN1/COL1A2/CREB3L2/ITGB1/COL1A1/COL4A1/CHD4/CDK6/GNAS/UBE3A/CSNK1A1/LFNG/LAMA2/PDGFRB/JAK1/COL6A1/AXIN2/COL4A2/EGFR/ATM/ITGA9/SOS2/ATP6V0D1/WNT5A/PIK3R1/TCF7L2/CREB5/HLA-E/ITGA6/PTK2/EP300/DLG1/TCF7L1/CREBBP/HEYL/LAMB1/CDKN1B/PTEN/EIF2AK2/FZD2/WNT16/LLGL1/IRF3/IRF9/PPP2R5A/TBK1/COL6A6/PPP2R2C/ITGA8/COL4A5/FZD7/AKT3/PIK3R3/VEGFA/RB1/COL6A3/PPP2CB/CREB3L1/FZD10/ITGAV/CREB1/STAT1/NFX1/HES4/ATP6V1E1/MAPK1/PRKACA/VWF/ATP6V0E2	5.77559270518746
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	21/1031	56/9376	3.41028128031038	SCUBE2/CSNK1A1/SMURF2/CUL3/CSNK1D/PTCH1/FBXW11/IQCE/EVC/SMO/SPOP/ARRB1/GLI1/GRK3/GPR161/EFCAB7/BTRC/KIF3A/CSNK1G3/CUL1/PRKACA	6.35851332070698
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	33/1031	117/9376	2.56499788604541	BPTF/CHD4/MORF4L1/RBBP4/SMARCA5/SMARCA1/SMARCC2/SMARCA2/RSF1/ARID1B/SMARCE1/BAZ2B/BAZ1B/YY1/BRD9/SMARCB1/PBRM1/BRD7/BAZ2A/DPF2/SMARCD1/EPC1/BRD8/CHD3/SMARCC1/ARID2/RBBP7/EPC2/GATAD2B/CECR2/BCL7A/EP400/PHF10	5.98723692723883
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	46/1031	203/9376	2.06072826133698	IGF1/FN1/COL1A2/ITGB1/COL1A1/COL4A1/ROCK2/PDGFRA/PPP1CB/PAK2/LAMA2/RAC1/PDGFRB/COL6A1/COL4A2/EMP2/EGFR/ITGA9/SOS2/DOCK1/PIK3R1/PGF/PIP5K1B/ITGA6/ROCK1/PTK2/PPP1R12A/LAMB1/PTEN/XIAP/TLN1/MYLK/COL6A6/ITGA8/COL4A5/AKT3/PIK3R3/VEGFA/COL6A3/SHC2/TLN2/PRKCA/ARHGAP35/ITGAV/MAPK1/VWF	5.37029647967091
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	27/1031	93/9376	2.64021776540158	WASF2/SNAI2/ROCK2/RAC1/SMURF2/HEG1/EGFR/CTNNA2/CTNNA1/TCF7L2/TJP1/AFDN/ROCK1/EP300/TCF7L1/CREBBP/ARHGAP29/CSNK2A2/SMAD3/SMAD4/IQGAP1/KRIT1/YES1/WASL/FER/MAPK1/NECTIN3	5.58728224886007
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	32/1031	122/9376	2.38533335453404	IGF1/CREB3L2/CACNA1D/SOCS2/GNAS/SOCS1/ITPR2/SOCS3/SOS2/PIK3R1/CREB5/ATF4/PTK2/EP300/CREBBP/GNAI1/ADCY6/ADCY5/MAP3K1/PLCG1/MAP2K6/AKT3/PIK3R3/GNAI3/CREB3L1/SHC2/PRKCA/ITPR3/CREB1/STAT1/MAPK1/PRKACA	5.41341421357705
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	40/1031	170/9376	2.13978433274377	CDK6/MGST3/GADD45G/CSNK1A1/SMARCC2/SMARCA2/ARID1B/AXIN2/EGFR/SOS2/SMARCE1/WNT5A/PIK3R1/TCF7L2/GSTM2/TCF7L1/SMARCB1/PBRM1/PTEN/FZD2/BRD7/SMAD3/SMAD4/WNT16/SMARCD1/PLCG1/FZD7/AKT3/PIK3R3/SMARCC1/ARID2/RB1/TGFB1/FZD10/SHC2/TGFB2/PRKCA/POLK/MAPK1/PHF10	5.27124811470235
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	35/1031	142/9376	2.24149943306785	PIAS1/UBE3A/SOCS1/SMURF2/SOCS3/CUL3/HERC2/UBE2Q2/UBE2R2/UBE2H/CUL5/XIAP/FBXW11/TRIP12/BIRC6/MAP3K1/UBE2E3/ANAPC5/NEDD4/FANCL/UBE2D2/FBXO2/VHL/UBE2Q1/CUL7/BTRC/HUWE1/ITCH/KLHL9/UBR5/DDB1/RNF7/CUL1/UBE2I/TRIM37	5.23959311737422
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	45/1031	204/9376	2.00604781194728	IGF1/FN1/COL1A2/ITGB1/COL1A1/ROCK2/CD63/PPP1CB/RDX/RAC1/HPSE2/ITPR2/CD44/EGFR/SOS2/PTCH1/WNT5A/PIK3R1/ROCK1/EIF4B/PTK2/PPP1R12A/ESR1/FRS2/ANK3/FZD2/WNT16/IQGAP1/PLCG1/SMO/FZD7/AKT3/PIK3R3/VEGFA/TGFB1/DDX5/FZD10/TGFB2/ARHGEF12/PRKCA/ITPR3/ITGAV/HOXD10/MAPK1/PRKACA	5.10626655459963
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	40/1031	174/9376	2.09059388831288	SEC31A/UBXN4/SSR3/SEC62/DNAJC1/LMAN1/RRBP1/ERLEC1/BCAP29/SSR2/ERP29/CKAP4/ATXN3/SEC61B/UBXN1/SEC23A/ATF4/SEC63/MBTPS1/SEC24D/SELENOS/DNAJA2/TMEM258/OS9/UGGT2/DNAJC3/DNAJC10/TRAM1/UBE2D2/FBXO2/ERO1B/UBXN2A/SEC13/VCP/TUSC3/SEC24A/KRTCAP2/MAN1A1/CUL1/ERN1	5.10385549307227
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	41/1031	184/9376	2.0263990216337	SEMA5A/GDF7/ITGB1/ROCK2/PAK2/EFNB2/RAC1/PTCH1/WNT5A/PIK3R1/ROCK1/PTK2/GNAI1/SLIT3/UNC5B/SEMA6A/PLXNB2/SRGAP2/PLCG1/SMO/PIK3R3/ENAH/GNAI3/LRIG2/SEMA4C/SEMA3D/ARHGEF12/ABLIM1/PRKCA/NFATC2/SRGAP1/RGMA/BMPR2/RGS3/EPHA5/SEMA3G/LRRC4/MAPK1/EPHA4/EFNB1/RASA1	4.94221840154477
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	20/1031	63/9376	2.88701060767016	NSD3/PLOD1/KMT2E/KMT2C/SETD2/KMT2A/NSD2/NSD1/KMT5B/EHMT1/ALDH7A1/ASH1L/HADHA/EZH1/KMT2B/EZH2/PRDM2/ALDH3A2/PHYKPL/KMT5C	5.28203914112384
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	31/1031	130/9376	2.16858912183839	COL3A1/COL1A2/CREB3L2/COL1A1/COL4A1/GNAS/COL4A2/EGFR/SOS2/PIK3R1/GNG11/CREB5/ATF4/GNAI1/ADCY6/ADCY5/COL4A5/GNB5/AKT3/PIK3R3/VEGFA/RXFP1/TGFB1/GNAI3/CREB3L1/SHC2/ARRB1/PRKCA/CREB1/MAPK1/PRKACA	4.71583250027821
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	22/1031	83/9376	2.41047994110292	RBBP4/RYBP/USP7/SUZ12/EP300/YY1/CREBBP/YAF2/EZH1/MTF2/BCOR/SCML1/EZH2/ASXL3/KDM2A/USP16/RBBP7/UBE2D2/JARID2/PHC1/ASXL2/MBD5	4.53659272748629
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	37/1031	178/9376	1.89034318159527	SFRP4/ROCK2/TLE1/DAAM2/CSNK1A1/RAC1/TLE4/AXIN2/SFRP1/WNT5A/DAAM1/DKK2/ROR1/TCF7L2/EP300/TCF7L1/CREBBP/CTBP2/SERPINF1/CHD8/CSNK2A2/FZD2/SMAD3/FBXW11/SMAD4/WNT16/FZD7/FZD10/PRKCA/NFATC2/BTRC/SIRT1/SOX17/CUL1/PRKACA/PRICKLE1/VANGL2	4.2152422250567
NA	NA	hsa04518	Integrin signaling	33/1031	154/9376	1.94873216017736	IGF1/FN1/COL1A2/ITGB1/COL1A1/COL4A1/PDGFRA/LAMA2/RAC1/PDGFRB/COL6A1/COL4A2/EGFR/ITGA9/PIK3R1/PGF/ITGA6/PTK2/LAMB1/FBN1/TLN1/COL6A6/ITGA8/COL4A5/AKT3/PIK3R3/VEGFA/COL6A3/TGFB1/NPNT/TLN2/ITGAV/VWF	4.17247001526366
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	33/1031	155/9376	1.93615969462783	RASD1/CREB3L2/CACNA1D/CDK6/GNAS/KMT2A/ITPR2/USP8/AXIN2/EGFR/WNT5A/TCF7L2/CREB5/ATF4/TCF7L1/GNAI1/CDKN1B/CACNA1G/ADCY6/FZD2/ADCY5/WNT16/PDE8A/CACNA1H/FZD7/RB1/GNAI3/CREB3L1/FZD10/ITPR3/CREB1/MAPK1/PRKACA	4.13074682296738
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	14/1031	44/9376	2.89357199541487	CREB3L2/GNAS/DYNC1I2/CREB5/VAMP2/DYNC1H1/ADCY6/DYNLL2/CREB3L1/DCTN2/DYNC1LI2/CREB1/RAB5A/PRKACA	4.42509496747299
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	33/1031	157/9376	1.91149523991919	GDF7/LIMD1/SNAI2/PPP1CB/FRMD6/AXIN2/CSNK1D/CTNNA2/WNT5A/CTNNA1/TCF7L2/YWHAZ/DLG1/TCF7L1/FZD2/SMAD3/FBXW11/SMAD4/WNT16/LLGL1/YWHAQ/PPP2R2C/TP53BP2/FZD7/AMOT/PPP2CB/TGFB1/FZD10/TGFB2/BMPR2/BTRC/STK3/WWTR1	4.04822016675927
Organismal Systems	Immune system	hsa04611	Platelet activation	28/1031	126/9376	2.02090742536911	COL3A1/COL1A2/ITGB1/COL1A1/ROCK2/GNAS/PPP1CB/STIM1/ITPR2/PIK3R1/GUCY1A2/ROCK1/PPP1R12A/GNAI1/ADCY6/ADCY5/TLN1/MYLK/AKT3/PIK3R3/GNAI3/ARHGEF12/TLN2/ARHGAP35/ITPR3/MAPK1/PRKACA/VWF	4.05510934275404
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	30/1031	139/9376	1.96275181600597	PGR/CREB3L2/GNAS/GREB1/ITPR2/EGFR/SOS2/FKBP5/PIK3R1/CREB5/NCOA1/ATF4/ESR1/CALM1/GNAI1/ADCY6/ADCY5/KRT18/KRT19/NCOA2/AKT3/PIK3R3/GNAI3/CREB3L1/SHC2/EBAG9/ITPR3/CREB1/MAPK1/PRKACA	4.01937081873673
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	46/1031	250/9376	1.67331134820563	DAB2/ARF5/PDGFRA/DNM1/ZFYVE16/ARFGAP3/AGAP1/SMURF2/USP8/AP2A1/EGFR/RUFY2/PIP5K1B/HLA-E/VPS36/VPS4B/CLTC/RABEP1/IGF2R/SPART/SMAD3/EPS15/IST1/VPS35/SNX6/RAB11FIP2/AP2B1/ARFGEF1/STAM2/RUFY1/WASHC2C/ARFGAP2/AP2A2/ACAP2/NEDD4/ASAP1/PDCD6IP/WASL/ARRB1/GRK3/SH3GLB1/FGFR2/ITCH/ZFYVE9/RAB5A/CHMP3	3.79269139849566
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	24/1031	106/9376	2.05903775414966	IGF1/CREB3L2/PDGFRA/AR/PDGFRB/EGFR/SOS2/PIK3R1/TCF7L2/CREB5/ATF4/EP300/TCF7L1/CREBBP/CDKN1B/PTEN/AKT3/PIK3R3/ZEB1/RB1/CREB3L1/FGFR2/CREB1/MAPK1	3.85412955015808
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	42/1031	227/9376	1.68260574182715	CREB3L2/ROCK2/CDK6/GNAS/PDGFRA/IL1R1/RAC1/ITPR2/JAK1/EGFR/SOS2/PIK3R1/GNG11/CREB5/HLA-E/ROCK1/ATF4/PTK2/CALM1/GNAI1/TAPBPL/ADCY6/ADCY5/IRF3/TBK1/GNB5/MAP2K6/AKT3/PIK3R3/VEGFA/RB1/GNAI3/CREB3L1/ARHGEF12/PRKCA/NFATC2/ITPR3/RIPK1/ITGAV/CREB1/MAPK1/PRKACA	3.65929862280863
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	19/1031	77/9376	2.24399460868908	CDK6/GADD45G/RALA/RAC1/JAK1/EGFR/PIK3R1/SMAD3/SMAD4/AKT3/PIK3R3/VEGFA/RB1/TGFB1/TGFB2/RALBP1/POLK/STAT1/MAPK1	3.85254337674291
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	28/1031	134/9376	1.90025623579484	KCNMB1/RAMP2/EDN3/CACNA1D/ROCK2/GNAS/EDNRA/PPP1CB/RAMP1/PPP1R14A/MYH10/ITPR2/GUCY1A2/KCNMA1/ROCK1/PPP1R12A/CALM1/ADCY6/ADCY5/MYLK/PLA2G12A/MYL6B/ARHGEF12/PRKCA/ITPR3/MAPK1/PRKACA/PRKCQ	3.68924379667316
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	25/1031	115/9376	1.97697465525239	CREB3L2/GNAS/ITPR2/MAFB/EGFR/CREB5/ATF4/GNAI1/MMP16/ADCY6/ADCY5/WNK1/GNAI3/CREB3L1/PDE4C/ARRB1/RUNX2/STK39/PRKCA/ITPR3/MMP15/CREB1/WNK2/MAPK1/PRKACA	3.70514386628556
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	23/1031	103/9376	2.03071765558935	PNN/FUS/SRRM1/PPP1CB/FIP1L1/UPF3A/MSI2/ACIN1/HBS1L/GSPT2/UPF2/PABPC4L/PAPOLA/WDR82/PPP2R5A/PCF11/PPP2R2C/PPP2CB/RNMT/SYMPK/PABPN1/CASC3/PABPC5	3.69700466103733
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	23/1031	103/9376	2.03071765558935	MME/COL3A1/ELN/COL1A2/COL18A1/COL14A1/COL5A3/COL1A1/COL4A1/COL5A2/COL6A1/COL4A2/COL23A1/COL7A1/COL5A1/ATP1B2/COL6A6/COL4A5/COL6A3/ATP1A1/SLC7A8/COL12A1/COL16A1	3.69700466103733
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	11/1031	34/9376	2.94220345752268	RORB/DBP/CSNK1D/FBXW11/PRKAG1/PRKAG2/CLOCK/BTRC/CREB1/CUL1/NPAS2	3.98764097828902
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	42/1031	233/9376	1.63927683860413	FN1/COL3A1/ELN/COL1A2/ITGB1/COL5A3/COL1A1/COL4A1/COL5A2/DAAM2/LAMA2/MYH10/COL6A1/SSPN/COL4A2/SNTB2/ITGA9/COL5A1/DAAM1/LBR/PDLIM4/ITGA6/FHL1/ANK3/ATP1B2/FBN1/TMOD1/TLN1/COL6A6/DSP/ITGA8/COL4A5/DSG2/COL6A3/SPTAN1/FLNC/ATP1A1/TLN2/TTN/ITGAV/FBN2/DMD	3.47315664328521
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	19/1031	80/9376	2.15984481086324	IGF1/PDGFRA/NRG2/PDGFRB/JAK1/EGFR/SOS2/PIK3R1/PTEN/NF1/PLCG1/NRG1/AKT3/PIK3R3/VEGFA/SHC2/PRKCA/FGFR2/MAPK1	3.66183372461701
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	20/1031	87/9376	2.09059388831288	GADD45G/RALA/RAC1/AXIN2/EGFR/SOS2/PIK3R1/TCF7L2/APPL1/TCF7L1/SMAD3/SMAD4/AKT3/PIK3R3/MSH6/TGFB1/TGFB2/MSH3/POLK/MAPK1	3.59203041035944
Human Diseases	Cancer: specific types	hsa05214	Glioma	18/1031	76/9376	2.15386186124866	IGF1/CDK6/PDGFRA/GADD45G/PDGFRB/EGFR/SOS2/PIK3R1/CALM1/PTEN/PLCG1/AKT3/PIK3R3/RB1/SHC2/PRKCA/POLK/MAPK1	3.54993941300488
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	22/1031	101/9376	1.98088945654992	FN1/COL3A1/COL1A2/COL1A1/COL4A1/F3/RAC1/COL4A2/PIK3R1/CDKN1B/SMAD3/SMAD4/PLCG1/COL4A5/AKT3/PIK3R3/VEGFA/TGFB1/TGFB2/PRKCA/STAT1/MAPK1	3.48357844356843
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	20/1031	89/9376	2.04361425037326	FN1/COL1A2/ITGB1/COL1A1/COL4A1/LAMA2/CD44/COL6A1/COL4A2/ITGA9/ITGA6/LAMB1/COL6A6/ITGA8/COL4A5/COL6A3/NPNT/ITGAV/CD36/VWF	3.47695509321468
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	20/1031	89/9376	2.04361425037326	GNAS/PDGFRA/PDGFRB/ITPR2/EGFR/TUBA3E/CSNK1D/SOS2/GUCY1A2/TJP1/GNAI1/ADCY6/ADCY5/TUBA3D/GNAI3/MAP3K2/PRKCA/ITPR3/MAPK1/PRKACA	3.47695509321468
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	30/1031	157/9376	1.73772294538108	CACNA1D/CDK6/PPP1CB/RBBP4/GADD45G/ITPR2/ZFP36L2/ATM/PIK3R1/HLA-E/CALM1/SQSTM1/PTEN/SMAD3/FBXW11/RAD50/MAP2K6/AKT3/PIK3R3/RB1/TGFB1/TGFB2/HIPK2/NFATC2/ITPR3/BTRC/SIRT1/MAPK1/HIPK1/RAD9A	3.27644596941342
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	30/1031	158/9376	1.72672469889133	CDK6/ATRX/PDS5B/GADD45G/SMC3/ATM/PRKDC/STAG2/YWHAZ/EP300/CREBBP/TFDP2/WAPL/RAD21/CDKN1B/NIPBL/SMAD3/SMAD4/STAG1/YWHAQ/PPP2R5A/ESCO1/ANAPC5/RB1/PPP2CB/TGFB1/TGFB2/CDC14A/CUL1/DDX11	3.23803778703755
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	21/1031	98/9376	1.94873216017736	CREB3L2/CACNA1D/GNAS/ITPR2/CREB5/ATF4/CALM1/CACNA1G/ADCY6/ADCY5/ATP1B2/PRKD3/CACNA1H/ATP2B1/CREB3L1/ATP1A1/PRKCA/ITPR3/PRKD1/CREB1/PRKACA	3.31841942283448
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	31/1031	166/9376	1.69829268577706	ADRA2C/KCNMB1/CREB3L2/CACNA1D/ROCK2/GTF2I/EDNRA/PPP1CB/ITPR2/GUCY1A2/CREB5/KCNMA1/ROCK1/ATF4/PPP1R12A/CALM1/GNAI1/PDE5A/ADCY6/ADCY5/ATP1B2/MYLK/AKT3/ATP2B1/GNAI3/CREB3L1/ATP1A1/NFATC2/ITPR3/CREB1/MAPK1	3.19053506727995
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	10/1031	33/9376	2.75578285277606	STX7/VAMP3/VAMP2/STX2/STX18/GOSR1/STX16/STX17/STX5/SEC22B	3.55129213208955
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	20/1031	93/9376	1.95571686326043	FN1/ITGB1/COL4A1/CDK6/GADD45G/LAMA2/COL4A2/PIK3R1/ITGA6/PTK2/LAMB1/CDKN1B/PTEN/XIAP/COL4A5/AKT3/PIK3R3/RB1/ITGAV/POLK	3.25557982462399
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	15/1031	62/9376	2.20018147116799	TLE1/ATXN1/LFNG/TLE4/CIR1/SNW1/NCOR2/EP300/CREBBP/HEYL/CTBP2/NUMBL/DTX3/ITCH/NUMB	3.33254824959815
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	26/1031	133/9376	1.77779074261794	CREB3L2/CACNA1D/GNAS/PPP1CB/ITPR2/GNG11/CREB5/ATF4/CALM1/GNAI1/ADCY5/PPP2R5A/PPP2R2C/GNB5/AKT3/PPP2CB/GNAI3/CREB3L1/GRIA4/ARRB1/PRKCA/ITPR3/CLOCK/SLC18A2/CREB1/PRKACA	3.17529379054428
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	22/1031	107/9376	1.86981154309853	CREB3L2/GNAS/ITPR2/PHKA2/CREB5/PHKB/ATF4/EP300/CALM1/CREBBP/PPP4R3B/PPP4R3A/PRKAG1/AKT3/CREB3L1/PRKAG2/CPT1A/ITPR3/SIRT1/CREB1/PRKACA/SIK2	3.18055137378979
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	17/1031	75/9376	2.0613255738765	CREB3L2/GNAS/ITPR2/CREB5/GPX7/ATF4/DUOX1/ADCY6/ADCY5/ATP1B2/CREB3L1/TTF1/ATP1A1/PRKCA/ITPR3/CREB1/PRKACA	3.24351745201349
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	21/1031	101/9376	1.89084902670674	CREB3L2/GNAS/WNT5A/TCF7L2/EP300/TCF7L1/CALM1/CREBBP/GNAI1/ADCY6/FZD2/ADCY5/WNT16/FZD7/GNAI3/CREB3L1/FZD10/PRKCA/CREB1/MAPK1/PRKACA	3.16380448906537
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	40/1031	235/9376	1.54792909177209	COX7C/MT-ND1/CREB3L2/ZNF516/GNAS/SMARCC2/SMARCA2/ARID1B/SOS2/SMARCE1/MT-CO1/CREB5/COX7A1/FRS2/SMARCB1/ACSL3/NDUFV3/ADCY6/ADCY5/SMARCD1/MT-ND6/PRKAG1/KDM1A/COA1/MT-ND4L/SMARCC1/MT-ATP8/CREB3L1/NDUFB1/PRKAG2/SLC25A29/CPT1A/RPS6KA2/NDUFA1/CREB1/NDUFS1/KDM3A/NDUFC2/NDUFB4/PRKACA	2.98994525431756
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	28/1031	150/9376	1.69756223731005	GADD45G/CSNK1A1/AXIN2/EGFR/CTNNA2/SOS2/WNT5A/PIK3R1/CTNNA1/TCF7L2/TCF7L1/CDKN1B/FZD2/SMAD3/SMAD4/WNT16/FGF9/FZD7/AKT3/PIK3R3/RB1/TGFB1/FZD10/SHC2/TGFB2/FGFR2/POLK/MAPK1	3.02707838269932
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	17/1031	77/9376	2.0077846498797	CDK6/GADD45G/SOS2/PIK3R1/CTBP2/CDKN1B/BCR/SMAD3/SMAD4/AKT3/PIK3R3/RB1/TGFB1/SHC2/TGFB2/POLK/MAPK1	3.12102162739165
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	19/1031	90/9376	1.91986205410066	IGF1/CREB3L2/EHMT1/PIK3R1/CREB5/ATF4/APPL1/ADCY6/ADCY5/PRKAG1/AKT3/PIK3R3/CAT/CREB3L1/PRKAG2/RB1CC1/SIRT1/CREB1/PRKACA	3.08199137651689
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	20/1031	97/9376	1.87506874518784	RASD1/CACNA1D/GNAS/GUCY1A2/GNG11/CALM1/GNAI1/CACNA1G/ADCY6/ADCY5/CACNA1H/GNB5/GNAI3/GRIA4/PRKCA/ITPR3/CREB1/RYR1/MAPK1/PRKACA	3.04494359802194
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	15/1031	65/9376	2.09863463403716	CREB3L2/CACNA1D/GNAS/ITPR2/CREB5/ATF4/CACNA1G/ADCY6/ADCY5/PDE8A/CACNA1H/CREB3L1/ITPR3/CREB1/PRKACA	3.12401852989608
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	14/1031	59/9376	2.15791809827549	GADD45G/AXIN2/EGFR/CTNNA2/SOS2/PIK3R1/CTNNA1/TCF7L2/TCF7L1/PTEN/AKT3/PIK3R3/POLK/MAPK1	3.13593895801237
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	13/1031	53/9376	2.23062423366213	GNAS/DNM1/AP2A1/ESR1/CLTC/ADCY6/ATP1B2/AP2B1/AP2A2/ATP2B1/ATP1A1/PRKCA/PRKACA	3.15781989133047
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	20/1031	98/9376	1.8559353906451	IP6K2/ITPR2/DGKB/PIK3R1/PIP5K1B/CALM1/PIK3C2A/PTEN/INPP5F/PLCG1/PIK3R3/DGKE/DGKD/SACM1L/DGKA/PRKCA/ITPR3/IMPA1/INPP5A/CDS2	2.99384035266302
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	20/1031	99/9376	1.83718856851738	WASF2/PDGFRA/RAC1/PDGFRB/GPCPD1/DGKB/EGFR/SOS2/PIK3R1/PIP5K1B/PLPP3/PLCG1/AKT3/PIK3R3/PLPP1/DGKE/DGKD/DGKA/PRKCA/MAPK1	2.94332967402636
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	18/1031	86/9376	1.90341280761509	KCNMB1/CREB3L2/CACNA1D/GNAS/PCLO/CREB5/KCNMA1/VAMP2/ATF4/ADCY6/ADCY5/ATP1B2/CREB3L1/ATP1A1/PRKCA/ITPR3/CREB1/PRKACA	2.95821280196591
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	18/1031	86/9376	1.90341280761509	ITGB1/CACNA1D/LAMA2/SSPN/SNTB2/CTNNA2/ITGA9/CTNNA1/TCF7L2/ITGA6/TCF7L1/DSP/ITGA8/DSG2/CDH2/ITGAV/CACNB3/DMD	2.95821280196591
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	27/1031	148/9376	1.65905575798883	IGF1/PGR/CDK6/GADD45G/CSNK1A1/AXIN2/EGFR/SOS2/WNT5A/PIK3R1/TCF7L2/NCOA1/TCF7L1/ESR1/HEYL/PTEN/FZD2/WNT16/FGF9/FZD7/AKT3/PIK3R3/RB1/FZD10/SHC2/POLK/MAPK1	2.8405407487969
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	7/1031	21/9376	3.03136113805367	CHST12/DSEL/CHST7/CHSY1/XYLT1/CSGALNACT1/CSGALNACT2	3.27549311954276
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	29/1031	163/9376	1.61796576080165	CREB3L2/JAK1/SOS2/DDX3X/PIK3R1/CREB5/ATF4/YWHAZ/EP300/CREBBP/SMAD3/SMAD4/IRF3/YWHAQ/MAP3K1/TBK1/MAP2K6/AKT3/PIK3R3/RB1/TGFB1/CREB3L1/TGFB2/PRKCA/NFATC2/CREB1/STAT1/DDB1/MAPK1	2.79743162359078
Organismal Systems	Endocrine system	hsa04924	Renin secretion	15/1031	69/9376	1.97697465525239	EDN3/CACNA1D/GNAS/EDNRA/ITPR2/GUCY1A2/KCNMA1/CALM1/GNAI1/ADCY6/ADCY5/GNAI3/ITPR3/CREB1/PRKACA	2.86289082098694
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	15/1031	69/9376	1.97697465525239	CREB3L2/CACNA1D/GNAS/PPP1CB/CREB5/ATF4/CALM1/ADCY5/CREB3L1/GRIA4/PRKCA/SLC18A2/SIRT1/CREB1/PRKACA	2.86289082098694
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	55/1031	362/9376	1.38169775629518	IGF1/FN1/COL1A2/CREB3L2/ITGB1/COL1A1/COL4A1/CDK6/PDGFRA/DDIT4/ANGPT1/LAMA2/RAC1/PDGFRB/JAK1/COL6A1/COL4A2/EGFR/ITGA9/SOS2/PIK3R1/PGF/PKN2/GNG11/CREB5/ITGA6/EIF4B/ATF4/YWHAZ/PTK2/LAMB1/CDKN1B/PTEN/FGF9/YWHAQ/PPP2R5A/COL6A6/PPP2R2C/ITGA8/COL4A5/GNB5/AKT3/PIK3R3/VEGFA/COL6A3/PPP2CB/CREB3L1/THEM4/MAGI2/PRKCA/FGFR2/ITGAV/CREB1/MAPK1/VWF	2.60325622646628
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	21/1031	110/9376	1.73614319724892	GDF7/ZFYVE16/SMURF2/LTBP1/ROCK1/EP300/SMAD5/CREBBP/SMAD3/SMAD4/FBN1/NCOR1/PPP2CB/NOG/TGFB1/TGFB2/RGMA/BMPR2/ZFYVE9/MAPK1/CUL1	2.72969609254843
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	12/1031	51/9376	2.13978433274377	SLC12A2/GNAS/KDELR1/KDELR3/ATP6V0D1/SEC61B/TJP1/PLCG1/PRKCA/ATP6V1E1/PRKACA/ATP6V0E2	2.8687001167865
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	15/1031	70/9376	1.94873216017736	PAK2/RAC1/SOS2/PIK3R1/EP300/CREBBP/AKT3/PIK3R3/VEGFA/EGLN2/TGFB1/VHL/ARNT2/TGFB2/MAPK1	2.80035389495822
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	24/1031	133/9376	1.64103760857041	IGF1/GADD45G/PLK2/EGFR/USP7/ATM/SOS2/PIK3R1/EP300/CREBBP/CDKN1B/PTEN/SMAD3/SMAD4/PRKAG1/AKT3/PIK3R3/CAT/TGFB1/TGFB2/PRKAG2/FBXO25/SIRT1/MAPK1	2.61700561149366
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	29/1031	169/9376	1.56052318941224	DDIT4/IGBP1/STX7/EIF2AK4/PIK3R1/HMGB1/CALCOCO2/SQSTM1/PTEN/ATG10/ATG14/BIRC6/MAP1LC3A/TBK1/LAMP2/AKT3/SUPT20H/PIK3R3/PPP2CB/STX17/SH3GLB1/RB1CC1/ULK2/NRBF2/MAPK1/PRKACA/PRKCQ/UVRAG/ERN1	2.58451862124101
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	36/1031	224/9376	1.46154912013302	CREB3L2/IL1R1/JAK1/ATM/XPO1/PIK3R1/CREB5/HLA-E/ATF4/EP300/ETS2/DLG1/CREBBP/PTEN/ADCY6/XIAP/SMAD3/ADCY5/SMAD4/TLN1/MSX1/MAP3K1/GPS2/AKT3/ANAPC5/PIK3R3/RB1/TGFB1/CREB3L1/TGFB2/TLN2/NFATC2/TCF3/CREB1/MAPK1/PRKACA	2.45745588969566
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	37/1031	232/9376	1.45034951001706	FN1/ITGB1/WASF2/ROCK2/PDGFRA/PPP1CB/RDX/PAK2/ABI2/RAC1/PDGFRB/MYH10/EGFR/ITGA9/SOS2/DOCK1/PIK3R1/PIP5K1B/ITGA6/ROCK1/PTK2/PPP1R12A/IQGAP1/FGF9/MYLK/ITGA8/AKT3/PIK3R3/CYFIP1/ENAH/WASL/ARHGEF12/ARHGEF7/ARHGAP35/FGFR2/ITGAV/MAPK1	2.44133500704798
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	21/1031	115/9376	1.66065871041201	CREB3L2/CACNA1D/ITPR2/PIK3R1/GNG11/CREB5/ATF4/GNAI1/ADCY6/ADCY5/KCNQ3/GNB5/AKT3/PIK3R3/GNAI3/CREB3L1/PRKCA/ITPR3/CREB1/MAPK1/PRKACA	2.50552617248685
NA	NA	hsa04519	Cadherin signaling	59/1031	404/9376	1.32809634018688	LIMD1/ROCK2/PDGFRA/PPP1CB/DAAM2/ABI2/CSNK1A1/RAC1/PDGFRB/RERE/AXIN2/EGFR/CTNNA2/WNT5A/DAAM1/ERBIN/CTNNA1/TCF7L2/TJP1/AFDN/ROCK1/YWHAZ/PTK2/EP300/TCF7L1/ADAM10/CREBBP/MPDZ/FZD2/LHFPL2/PCDH9/KRT18/WNT16/KRT8/KRT19/DCHS1/YWHAQ/TAOK1/DSP/FZD7/DSG2/CYFIP1/ENAH/FZD10/GABRP/PCDHGC3/SCN5A/PCDHGB7/CIB2/CDH2/ARHGAP35/LHFPL3/STK3/FAT1/MAPK1/PCDH7/WWTR1/PRICKLE1/VANGL2	2.36945920815634
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	25/1031	144/9376	1.57883392606962	IGF1/TBX3/JAK1/AXIN2/WNT5A/REST/PIK3R1/SMAD5/ZFHX3/FZD2/SMAD3/SMAD4/SMARCAD1/WNT16/FZD7/AKT3/PIK3R3/JARID2/FZD10/KAT6A/TCF3/BMPR2/FGFR2/MAPK1/RIF1	2.46030600219904
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	34/1031	212/9376	1.45848507585601	IGF1/ITGB1/GNAS/PDGFRA/ANGPT1/SIPA1L1/RALA/RAC1/PDGFRB/EGFR/PIK3R1/PGF/AFDN/CALM1/GNAI1/ADCY6/ADCY5/PRKD3/TLN1/FGF9/KRIT1/PLCG1/MAP2K6/AKT3/PIK3R3/VEGFA/ENAH/GNAI3/MAGI2/TLN2/PRKCA/PRKD1/FGFR2/MAPK1	2.37329866019674
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	24/1031	138/9376	1.58157972420191	FN1/ITGB1/WASF2/ROCK2/RAC1/DOCK1/PIK3R1/PKN2/PIP5K1B/ROCK1/PTK2/IRF3/PLCG1/TBK1/MAP2K6/AKT3/PIK3R3/WASL/ARHGEF12/ARHGEF7/PYCARD/NFATC2/RPS6KA2/MAPK1	2.41914344941345
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	11/1031	49/9376	2.04152892970961	CREB3L2/GNAS/CREB5/ATF4/GNAI1/ADCY5/GNAI3/CREB3L1/SLC18A2/CREB1/PRKACA	2.56921346513248
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	19/1031	103/9376	1.67754936766077	FN1/COL3A1/COL1A2/COL1A1/COL4A1/GNAS/IL1R1/LAMA2/COL4A2/PIK3R1/PTK2/LAMB1/COL4A5/PIK3R3/TGFB1/TGFB2/PRKCA/RAB5A/PRKACA	2.43025154050794
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	13/1031	63/9376	1.8765568949856	GADD45G/AXIN2/PTCH1/WNT5A/TCF7L2/TCF7L1/FZD2/WNT16/SMO/FZD7/FZD10/GLI1/POLK	2.45362045656568
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	19/1031	105/9376	1.64559604637199	IGF1/ITGB1/CACNA1D/GNAS/LAMA2/SSPN/SNTB2/ITGA9/ITGA6/ADCY6/ADCY5/ITGA8/TGFB1/TGFB2/TTN/ITGAV/CACNB3/DMD/PRKACA	2.338266574319
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	15/1031	78/9376	1.74886219503096	FN1/ARHGAP10/ITGB1/WASF2/DNM1/RAC1/CTNNA2/DOCK1/PIK3R1/CTNNA1/PTK2/CLTC/PIK3R3/SHC2/WASL	2.33429767416485
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	35/1031	226/9376	1.40837574998069	CREB3L2/EDN3/CACNA1D/ROCK2/GNAS/EDNRA/PPP1CB/RAC1/FXYD1/PTCH1/PIK3R1/CREB5/AFDN/ROCK1/EP300/PPP1R12A/CALM1/CREBBP/GNAI1/ADCY6/ADCY5/ATP1B2/AKT3/ATP2B1/PIK3R3/GNAI3/CREB3L1/PDE4C/GRIA4/ATP1A1/GLI1/CREB1/ACOX1/MAPK1/PRKACA	2.18426545825957
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	13/1031	65/9376	1.8188166828322	LPIN2/DGKB/ALDH7A1/PLPP5/PLPP3/PLPP1/DGKE/LCLAT1/DGKD/DGKA/ALDH3A2/MBOAT1/AGPAT3	2.32834320938523
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	9/1031	39/9376	2.09863463403716	BHMT2/CHDH/ALDH7A1/ALDH1L1/GCSH/MTR/AHCYL1/BHMT/AHCYL2	2.41648281135398
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	31/1031	196/9376	1.43834992774996	CDK6/RAC1/ITPR2/JAK1/PIK3R1/GNG11/TCF7L2/HLA-E/EP300/TCF7L1/CALM1/CREBBP/EIF2AK2/PREX1/IRF3/IRF9/ATG14/MAP1LC3A/PLCG1/TBK1/GNB5/MAP2K6/AKT3/PIK3R3/VEGFA/RB1/NFATC2/ITPR3/CREB1/STAT1/MAPK1	2.17986417849527
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	21/1031	122/9376	1.56537501391296	DIO2/THRA/PIK3R1/NCOA1/EP300/MED13/ESR1/CREBBP/ATP1B2/NCOR1/PLCG1/NCOA2/AKT3/PIK3R3/ATP1A1/PRKCA/MED4/ITGAV/STAT1/MAPK1/PRKACA	2.20929433793009
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	14/1031	73/9376	1.74407079175691	MAP1B/PSIP1/AFF4/XPO1/EP300/VPS4B/SMARCB1/CREBBP/CCNT2/MLLT3/BICD1/PDCD6IP/APOBEC3C/TRIM5	2.24318956857663
Human Diseases	Cancer: specific types	hsa05218	Melanoma	14/1031	73/9376	1.74407079175691	IGF1/CDK6/PDGFRA/GADD45G/PDGFRB/EGFR/PIK3R1/PTEN/FGF9/AKT3/PIK3R3/RB1/POLK/MAPK1	2.24318956857663
NA	NA	hsa04517	IgSF CAM signaling	44/1031	299/9376	1.33825976663239	ITGB1/NTRK3/RDX/PAK2/RAC1/MYH10/SLITRK6/TUBA3E/EPB41L2/PIK3R1/TJP1/AFDN/PTK2/MPDZ/SLIT3/UNC5B/DYNLL2/ANK3/IQGAP1/SRGAP2/TUBA3D/MYLK/ERC1/CASK/PLCG1/KCNQ3/AKT3/PIK3R3/MYL6B/SPTAN1/WASL/MAGI2/CDH2/PRKCA/SRGAP1/LRRC4B/TRIO/TIGIT/NRCAM/MAPK1/NECTIN3/PTPRS/PRKCQ/RASA1	2.08937585513356
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	23/1031	138/9376	1.51568056902683	IGF1/PGR/PPP1CB/AR/ITPR2/SMC3/YWHAZ/CALM1/ADCY6/ADCY5/FBXW11/SLK/YWHAQ/PPP2R5A/ANAPC5/PPP2CB/CPEB4/ITPR3/RPS6KA2/BTRC/MAPK1/CUL1/PRKACA	2.14502882173718
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	45/1031	308/9376	1.32868101830274	COX7C/MT-ND1/CREB3L2/POLR2A/AP2A1/TUBA3E/MT-CO1/REST/PSMD12/CREB5/GPX7/EP300/COX7A1/RCOR1/CREBBP/CLTC/HIP1/DNALI1/NDUFV3/SLC1A2/TUBA3D/ATG14/AP2B1/MT-ND6/POLR2B/AP2A2/DNAH9/MT-ND4L/POLR2J3/KLC1/MT-ATP8/CREB3L1/NDUFB1/GRIA4/DCTN2/RB1CC1/NDUFA1/CREB1/ULK2/NDUFS1/NRBF2/NDUFC2/NDUFB4/ERN1/IFT57	2.06156022579357
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	19/1031	109/9376	1.58520720063357	CREB3L2/PPP1CB/SOCS3/PIK3R1/CREB5/PTEN/PRKAG1/AKT3/PIK3R3/CREB3L1/MLXIP/PRKAG2/CPT1A/RPS6KA2/GFPT1/CREB1/CD36/PPP1R3B/PRKCQ	2.16000685296024
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	38/1031	253/9376	1.36590976181074	ITGB1/WASF2/ROCK2/IL1R1/RAC1/ITPR2/CD44/EGFR/ATM/DOCK1/PIK3R1/ROCK1/PTK2/CALCOCO2/SQSTM1/FNBP1/FBXW11/TLN1/IRF3/ATG14/MAP1LC3A/PLCG1/TBK1/UBE2V1/AKT3/PIK3R3/UBE2D2/FNBP1L/WASL/PYCARD/TLN2/ITPR3/RIPK1/BTRC/MAPK1/CUL1/MALT1/PRKCQ	2.07380166737594
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	25/1031	154/9376	1.47631224255861	CREB3L2/CACNA1D/GNAS/PPP1CB/CREB5/ATF4/CALM1/GNAI1/ADCY6/ADCY5/ATP1B2/PPP2R5A/PPP2R2C/AKT3/ATP2B1/PPP2CB/GNAI3/CREB3L1/SCN5A/ATP1A1/PRKCA/CREB1/CACNB3/MAPK1/PRKACA	2.09479411935107
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	25/1031	154/9376	1.47631224255861	CACNA1D/ROCK2/GNAS/PPP1CB/ITPR2/EGFR/GUCY1A2/ROCK1/PPP1R12A/CALM1/GNAI1/ADCY6/ADCY5/MYLK/PRKAG1/MYL6B/GNAI3/PRKAG2/PRKCA/NFATC2/ITPR3/RYR1/CACNB3/MAPK1/PRKACA	2.09479411935107
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	24/1031	149/9376	1.46481880496553	GNAS/PDGFRA/DNM1/RALA/PDGFRB/DGKB/EGFR/SOS2/PIK3R1/PIP5K1B/ADCY6/ADCY5/PLPP3/PLCG1/AKT3/PIK3R3/PLPP1/SHC2/DGKE/DGKD/DGKA/PRKCA/MAPK1/AGPAT3	2.01024209981698
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	14/1031	76/9376	1.67522589208229	GNAS/ITPR2/SLC26A7/CALM1/GNAI1/ADCY6/ADCY5/ATP1B2/MYLK/GNAI3/ATP1A1/PRKCA/ITPR3/PRKACA	2.07738125982461
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	37/1031	250/9376	1.34592434529583	LAPTM4A/CD63/CTSF/CTSH/MCOLN3/AP2A1/ATP6V0D1/VPS13C/CTSZ/FUCA1/MCOLN2/HGSNAT/LAPTM4B/AP4M1/BORCS7/CLTC/IGF2R/VPS35/OSBPL1A/AP2B1/AP2A2/IDS/LAMP2/OSBPL2/TPCN1/STX17/AP5M1/BLOC1S6/AP3B1/GNPTAB/ABCB9/CLN5/ABCA5/ATP6V1E1/AP3S2/ATP6V0E2/ENTPD4	1.9485551408426
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	31/1031	205/9376	1.37520285775118	CREB3L2/CHD4/CDK6/UBE3A/RAC1/JAK1/USP7/SNW1/ATP6V0D1/DDX3X/PIK3R1/CREB5/HLA-E/ATF4/YWHAZ/EP300/DLG1/CREBBP/CDKN1B/SND1/EIF2AK2/IRF3/IRF9/YWHAQ/PIK3R3/RB1/CREB3L1/CREB1/DDB1/MAPK1/PRKACA	1.90913448167304
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	31/1031	205/9376	1.37520285775118	COL3A1/COX7C/MT-ND1/COL1A2/COL1A1/PPP1CB/RAC1/MT-CO1/PIK3R1/COX7A1/PARP1/PTEN/PDK4/NDUFV3/MPC2/SMAD3/MT-ND6/AKT3/MT-ND4L/PIK3R3/TGFB1/MT-ATP8/NDUFB1/TGFB2/PRKCA/GFPT1/NDUFA1/CD36/NDUFS1/NDUFC2/NDUFB4	1.90913448167304
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	17/1031	99/9376	1.56161028323977	IGF1/GNAS/EGFR/SOS2/PIK3R1/PTK2/ESR1/CDKN1B/ADCY6/ADCY5/NCOR1/AKT3/PIK3R3/RB1/SHC2/MAPK1/PRKACA	1.97447059606339
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	17/1031	99/9376	1.56161028323977	IGF1/GNAS/PPP1CB/IL1R1/ITPR2/PIK3R1/CALM1/ADCY6/ADCY5/PLCG1/MAP2K6/PIK3R3/PRKCA/ITPR3/PRKACA/ASIC2/PRKCQ	1.97447059606339
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	17/1031	99/9376	1.56161028323977	IGF1/ITGB1/CACNA1D/LAMA2/SSPN/SNTB2/ITGA9/ITGA6/PRKAG1/ITGA8/TGFB1/TGFB2/PRKAG2/TTN/ITGAV/CACNB3/DMD	1.97447059606339
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	9/1031	43/9376	1.90341280761509	ECI2/ALDH7A1/ACSL3/HADHA/ACAA2/ACADM/CPT1A/ALDH3A2/ACOX1	2.08694805023271
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	10/1031	50/9376	1.8188166828322	P4HA2/CKB/OAT/ALDH7A1/P4HA1/GAMT/P4HA3/ODC1/ALDH3A2/SMOX	2.04044916540671
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	32/1031	214/9376	1.35986294043529	PAK2/RAC1/ITPR2/ATM/PIK3R1/GNG11/HLA-E/PTK2/CALM1/CUL5/GNAI1/TAPBPL/FBXW11/IRF3/PLCG1/TBK1/GNB5/MAP2K6/AKT3/PIK3R3/GNAI3/PRKCA/NFATC2/ITPR3/APOBEC3C/RIPK1/BTRC/TRIM5/DDB1/RNF7/MAPK1/CUL1	1.87176217858293
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	14/1031	78/9376	1.6322713820289	DHX36/BTG2/DDX6/DCP2/CNOT4/PABPC4L/DIS3/CNOT6L/XRN1/XRN2/TOB2/ZCCHC7/PABPC5/BTG3	1.97086944207409
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	22/1031	137/9376	1.46036375993826	CTSF/CTSH/GADD45G/ITPR2/TUBA3E/ATM/PIK3R1/CTSZ/ATF4/PARP1/XIAP/PTPN13/TUBA3D/AKT3/PIK3R3/SPTAN1/ITPR3/RIPK1/CASP6/PARP4/MAPK1/ERN1	1.9078785652057
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	20/1031	122/9376	1.49083334658377	IGF1/CREB3L2/RAB2A/RAB14/PIK3R1/CREB5/PPP2R5A/PRKAG1/PPP2R2C/AKT3/PIK3R3/PPP2CB/CREB3L1/SCD/PRKAG2/CPT1A/SCD5/SIRT1/CREB1/CD36	1.91801071287127
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	8/1031	37/9376	1.96628830576454	TPR/GADD45G/TCF7L2/TCF7L1/CCDC6/POLK/MAPK1/TFG	2.06994686946254
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	16/1031	93/9376	1.56457349060835	CACNA1D/GNAS/ITPR2/EGFR/SOS2/ATF4/CALM1/ADCY6/ADCY5/MAP3K1/MAP2K6/MAP3K2/PRKCA/ITPR3/MAPK1/PRKACA	1.92317843934623
Organismal Systems	Digestive system	hsa04970	Salivary secretion	16/1031	93/9376	1.56457349060835	SLC12A2/GNAS/ITPR2/GUCY1A2/KCNMA1/VAMP2/CALM1/ADCY6/ADCY5/ATP1B2/ATP2B1/ATP1A1/PRKCA/ITPR3/CST1/PRKACA	1.92317843934623
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	32/1031	217/9376	1.34106299195001	PGR/CREB3L2/CACNA1D/GNAS/KPNA2/MGST3/AR/EGFR/SOS2/PIK3R1/CREB5/ATF4/GSTM2/ESR1/GNAI1/ADCY6/XIAP/EPHX2/ADCY5/FGF9/AKT3/PIK3R3/VEGFA/RB1/GNAI3/CREB3L1/ARRB1/PRKCA/RPS6KA2/CREB1/MAPK1/PRKACA	1.7866613198987
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	8/1031	38/9376	1.91454387666548	IGF1/HSD11B2/PIK3R1/ATP1B2/PIK3R3/ATP1A1/PRKCA/MAPK1	1.98550602886882
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	23/1031	149/9376	1.40378468809197	MT-ND1/CACNA1D/ITPR2/GNG11/GNAI1/NDUFV3/ADCY6/ADCY5/MT-ND6/GNB5/MT-ND4L/GNAI3/NDUFB1/GRIA4/GABRP/PRKCA/ITPR3/NDUFA1/NDUFS1/NDUFC2/NDUFB4/MAPK1/PRKACA	1.74628257418314
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	11/1031	60/9376	1.66724862592952	RAC1/PIK3R1/PTK2/PLCG1/AKT3/PIK3R3/VEGFA/SHC2/PRKCA/NFATC2/MAPK1	1.82242797637741
Organismal Systems	Nervous system	hsa04730	Long-term depression	11/1031	60/9376	1.66724862592952	IGF1/GNAS/ITPR2/GUCY1A2/GNAI1/PPP2CB/GNAI3/PRKCA/ITPR3/RYR1/MAPK1	1.82242797637741
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	17/1031	104/9376	1.48653286577632	PEMT/LPIN2/GPCPD1/DGKB/PLD3/LPGAT1/PLPP5/PLPP3/PLA2G12A/PLPP1/DGKE/LCLAT1/DGKD/DGKA/MBOAT1/CDS2/AGPAT3	1.75365412496952
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	13/1031	75/9376	1.57630779178791	REV3L/MGST3/ATM/PIK3R1/TOP2B/GSTM2/XPA/XIAP/AKT3/PIK3R3/MSH6/MSH3/MAPK1	1.7612544410552
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	11/1031	62/9376	1.61346641218986	IGF1/PIK3R1/ADCY6/ADCY5/PRKAG1/AKT3/PIK3R3/CAT/PRKAG2/SIRT1/PRKACA	1.70341441460598
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	63/1031	480/9376	1.19359844810863	COX7C/MT-ND1/CACNA1D/FUS/ATXN1/CSNK1A1/RAC1/ITPR2/AXIN2/ATXN2/ATXN3/TUBA3E/SNCAIP/MT-CO1/WNT5A/DKK2/PSMD12/NEFM/GPX7/ATF4/COX7A1/CALM1/HIP1/SQSTM1/DNALI1/NDUFV3/CSNK2A2/FZD2/WNT16/CCS/TUBA3D/ATG14/MAP1LC3A/MT-ND6/PLCG1/TBK1/DNAH9/MAP2K6/FZD7/MT-ND4L/CAT/KLC1/MT-ATP8/FZD10/UCHL1/NDUFB1/GRIA4/DCTN2/VCP/PRKCA/ITPR3/RB1CC1/NDUFA1/ULK2/RAB5A/NDUFS1/NRBF2/RYR1/NDUFC2/NDUFB4/MAPK1/ERN1/IFT57	1.53047733888484
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	25/1031	170/9376	1.33736520796485	ITGB1/CACNA1D/ROCK2/RDX/RAC1/MYH10/TUBA3E/TJP1/AFDN/ROCK1/DLG1/MPDZ/CGNL1/LLGL1/TUBA3D/MAP3K1/PRKAG1/PPP2R2C/NEDD4/AMOT/MYL6B/PPP2CB/SYMPK/PRKAG2/PRKACA	1.56023877970841
Genetic Information Processing	Transcription	hsa03040	Spliceosome	34/1031	243/9376	1.27242319375092	SF3B1/FUS/RBM25/SRSF5/U2SURP/DDX46/SYF2/TRA2B/SNW1/DDX42/CDC5L/ACIN1/SF1/CDC40/SF3B2/SRSF6/PRPF6/RBMX2/CWC25/HNRNPA3/SRSF10/TRA2A/SRSF4/SNRNP200/DHX8/DDX5/CCDC12/CRNKL1/CWC15/CASC3/RBM17/PRPF8/SLU7/SNIP1	1.51231509967512
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	14/1031	86/9376	1.48043218370063	NRG2/PAK2/EGFR/SOS2/PIK3R1/PTK2/CDKN1B/PLCG1/NRG1/AKT3/PIK3R3/SHC2/PRKCA/MAPK1	1.57316857179775
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	10/1031	57/9376	1.59545323055456	FADS2/HACD3/ACSL3/HADHA/ACAA2/ACADM/SCD/CPT1A/SCD5/ACOX1	1.58490132365419
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	6/1031	29/9376	1.88153449948159	RASSF2/LIMD1/FRMD6/DCHS1/STK3/WWTR1	1.67110597233766
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	33/1031	238/9376	1.26094433893829	IGF1/PDGFRA/ANGPT1/PAK2/RALA/RAC1/PDGFRB/EGFR/RGL2/SOS2/PIK3R1/PGF/GNG11/AFDN/ETS2/CALM1/NF1/FGF9/PLCG1/TBK1/GNB5/PLA2G12A/AKT3/PIK3R3/VEGFA/SHC2/RALBP1/PRKCA/FGFR2/RAB5A/MAPK1/PRKACA/RASA1	1.43321908107778
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	11/1031	65/9376	1.53899873162725	CACNA1D/ITPR2/PIK3R1/CACNA1G/CACNA1H/AKT3/PIK3R3/ARRB1/PRKCA/ITPR3/MAPK1	1.53266788887438
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	12/1031	73/9376	1.49491782150592	CDK6/GADD45G/EGFR/SOS2/PIK3R1/PLCG1/AKT3/PIK3R3/RB1/PRKCA/POLK/MAPK1	1.49205493187462
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	18/1031	120/9376	1.36411251212415	NTRK3/KIDINS220/RAC1/BEX3/SOS2/MAGED1/PIK3R1/ATF4/FRS2/CALM1/ZNF274/MAP3K1/PLCG1/AKT3/PIK3R3/SHC2/RPS6KA2/MAPK1	1.41096536545307
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	4/1031	17/9376	2.13978433274377	MYH10/PCDH9/LAMP2/PCDH7	1.65323358903287
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	11/1031	67/9376	1.49305847098166	PPP1CB/ITPR2/ATF4/EP300/CALM1/CREBBP/PRKCA/ITPR3/RPS6KA2/MAPK1/PRKACA	1.42359387609579
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	15/1031	98/9376	1.39195154298383	WASF2/RAC1/DOCK1/PIK3R1/PIP5K1B/MARCKSL1/PLPP3/PLCG1/AKT3/PIK3R3/ASAP1/PLPP1/MYO10/PRKCA/MAPK1	1.3709450018057
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	6/1031	31/9376	1.76014517693439	CSAD/ALDH7A1/HADHA/ALDH3A2/ACOX1/SMOX	1.4900112198288
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	6/1031	31/9376	1.76014517693439	SEC62/SRP14/SEC61B/SRP54/SEC63/SRPRA	1.4900112198288
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	13/1031	83/9376	1.42437451065172	ECI2/ACSL3/EPHX2/ACOX2/XDH/CAT/PEX1/FAR1/FAR2/PEX11A/ABCD4/ACOX1/HMGCL	1.36493562414489
Human Diseases	Substance dependence	hsa05032	Morphine addiction	14/1031	91/9376	1.39908975602477	GNAS/GNG11/GNAI1/ADCY6/ADCY5/PDE8A/GNB5/GNAI3/PDE4C/ARRB1/GABRP/GRK3/PRKCA/PRKACA	1.34462791384259
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	22/1031	155/9376	1.29077312975189	ITGB1/MRC2/DYNC1I2/RAC1/TUBA3E/ATP6V0D1/STX7/SEC61B/VAMP3/HLA-E/DYNC1H1/STX18/TUBA3D/LAMP2/COLEC12/DYNC1LI2/ITGAV/CD36/RAB5A/ATP6V1E1/SEC22B/ATP6V0E2	1.28301847304416
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	22/1031	156/9376	1.28249894302271	CDK6/PIAS1/SOCS3/JAK1/EIF3E/EGFR/SOS2/PIK3R1/YWHAZ/EIF2AK2/IRF3/IRF9/YWHAQ/TBK1/PPP2R2C/AKT3/PIK3R3/RB1/PPP2CB/RIPK1/STAT1/MAPK1	1.25059148177098
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	17/1031	116/9376	1.33275360379946	CACNA1D/GNAS/ITPR2/GNG11/SHANK2/GNAI1/ADCY6/ADCY5/SLC1A2/GNB5/GNAI3/GRIA4/GRK3/PRKCA/ITPR3/MAPK1/PRKACA	1.26750029560082
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	9/1031	54/9376	1.51568056902683	REV3L/WDR48/REV1/RMI1/FAN1/FANCL/POLI/USP1/POLK	1.33574912491539
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	22/1031	157/9376	1.27433015994613	CD24/RAB14/RAC1/DOCK1/PTK2/ADAM10/ANO4/LRP1/ODC1/TGFB1/CPT1A/NFATC2/DNMT3A/TMEM30A/ABCA1/ITGAV/SIRT1/CREB1/CD36/RAB5A/MAPK1/MERTK	1.2183814431578
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	8/1031	47/9376	1.54792909177209	CACNA1D/SOCS2/SOCS1/SOCS3/PIK3R1/CACNA1G/PIK3R3/MAPK1	1.32360238871134
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	18/1031	125/9376	1.30954801163919	ROCK2/RAC1/ORMDL1/PIK3R1/ROCK1/GNAI1/PTEN/PPP2R5A/PPP2R2C/AKT3/PIK3R3/PPP2CB/GNAI3/SPTLC1/S1PR3/PRKCA/ORMDL3/MAPK1	1.22458936948292
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	10/1031	63/9376	1.44350530383508	XPC/POLR2A/RFC1/XPA/ERCC6/POLR2B/POLR2J3/MNAT1/UVSSA/DDB1	1.24144102032647
NA	NA	hsa03272	Virion - Hepatitis viruses	8/1031	48/9376	1.51568056902683	CD63/EGFR/EPCAM/VPS4B/IST1/TGOLN2/LAMP2/PDCD6IP	1.25895126254833
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	11/1031	71/9376	1.40894250078551	SOCS2/SOCS1/SOCS3/SOS2/PIK3R1/ESR1/AKT3/PIK3R3/SHC2/STAT1/MAPK1	1.2157241234764
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	11/1031	71/9376	1.40894250078551	NTRK3/PDGFRA/PDGFRB/EGFR/PIK3R1/PTEN/AKT3/PIK3R3/SLC16A3/FGFR2/MAPK1	1.2157241234764
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	47/1031	368/9376	1.16147260996078	COX7C/MT-ND1/FUS/TPR/NRG2/RAC1/ATXN2/TUBA3E/MT-CO1/PSMD12/NEFM/GPX7/ATF4/COX7A1/SETX/SQSTM1/DNALI1/NDUFV3/SLC1A2/CCS/HNRNPA3/TUBA3D/ATG14/MAP1LC3A/MT-ND6/TBK1/DNAH9/MAP2K6/NRG1/MT-ND4L/CAT/KLC1/MT-ATP8/NDUFB1/DCTN2/SEC13/VCP/ITPR3/RB1CC1/NDUFA1/ULK2/RAB5A/NDUFS1/NRBF2/NDUFC2/NDUFB4/ERN1	1.11073481834149
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	12/1031	79/9376	1.38137975911306	DNM1/AP2A1/ATP6V0D1/VAMP2/CLTC/STX2/SLC1A2/AP2B1/AP2A2/SLC18A2/ATP6V1E1/ATP6V0E2	1.19646933029805
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	27/1031	201/9376	1.22159329443954	IGF1/HOXA11/HOXA10/FUS/JMJD1C/GADD45G/KMT2A/NSD2/HOXA9/ATM/PTK2/CDKN1B/HPGD/WNT16/NCOR1/CCNT2/CDK14/MLLT3/ZEB1/DDX5/ARNT2/TAF15/KLF3/RUNX2/LDB1/TCF3/POLK	1.1162292707861
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	20/1031	144/9376	1.2630671408557	LPIN2/TRA2B/ALDH7A1/TCF7L2/TCF7L1/IRF3/PRKAG1/TRA2A/TBK1/MAP2K6/AKT3/ACADM/SCD/PRKAG2/CPT1A/ALDH3A2/RIPK1/SCD5/SIRT1/ACOX1	1.11815433836676
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	30/1031	227/9376	1.20186124416225	COX7C/MT-ND1/MGST3/RAC1/EGFR/SOS2/MT-CO1/PIK3R1/GSTM2/PTK2/COX7A1/PTEN/NDUFV3/EPHX2/PRKD3/MT-ND6/AKT3/MT-ND4L/PIK3R3/CAT/VEGFA/MT-ATP8/NDUFB1/PRKD1/NDUFA1/CBR1/NDUFS1/NDUFC2/NDUFB4/MAPK1	1.08213354722762
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	3/1031	13/9376	2.09863463403716	XRCC5/PRKDC/RAD50	1.39321855778823
Cellular Processes	Cell motility	hsa04814	Motor proteins	26/1031	194/9376	1.21879468437209	HOOK3/DYNC1I2/MYH10/KIFAP3/TUBA3E/DYNC1H1/MYO9A/DNALI1/DYNLL2/KIF2A/MYO5B/TUBA3D/KIF27/KIF21A/DNAH9/MYL6B/KLC1/KIF1B/MYO15B/DCTN2/MYO18A/DYNC1LI2/MYO10/KIF3A/KIF13B/KIF3B	1.08235764158409
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	5/1031	27/9376	1.68408952114093	FADS2/HACD3/SCD/SCD5/ACOX1	1.25116342566255
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	13/1031	90/9376	1.31358982648992	JAK1/EGFR/PIK3R1/PTEN/CSNK2A2/PLCG1/MAP2K6/AKT3/PIK3R3/NFATC2/STAT1/MAPK1/PRKCQ	1.05068051964628
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	4/1031	21/9376	1.7322063646021	CSAD/ENPP3/ALDH3A2/PPCS	1.18065511070943
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	23/1031	173/9376	1.20903999147805	CDK6/KPNA2/SOCS3/JAK1/XPO1/PIK3R1/EP300/CALCOCO2/CREBBP/EIF2AK2/HNRNPUL1/IRF3/IRF9/DNAJC3/TBK1/AKT3/PIK3R3/ADAR/PYCARD/PRKCA/PABPN1/STAT1/MAPK1	0.975415202096771
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	9/1031	59/9376	1.3872330631771	GNAS/PIK3R1/GNAI1/ADCY6/ADCY5/AKT3/PIK3R3/GNAI3/PRKACA	1.04872637404673
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	19/1031	140/9376	1.23419703477899	ITPR2/GNG11/CALM1/GNAI1/ADCY6/SMAD3/ADCY5/SMAD4/MYLK/MAP1LC3A/PRKAG1/GNB5/AKT3/GNAI3/PRKAG2/ITPR3/RYR1/MAPK1/PRKACA	0.981307793765855
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	21/1031	157/9376	1.21640606176676	COX7C/RAC1/SOCS3/MT-CO1/PIK3R1/ATF4/COX7A1/NDUFV3/PRKAG1/AKT3/PIK3R3/TGFB1/NDUFB1/MLXIP/PRKAG2/NDUFA1/ITCH/NDUFS1/NDUFC2/NDUFB4/ERN1	0.961123377375851
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	16/1031	116/9376	1.25435633298773	ITGB1/ROCK2/RAC1/CTNNA2/PIK3R1/CTNNA1/AFDN/ROCK1/PTK2/GNAI1/PLCG1/PIK3R3/GNAI3/PRKCA/ARHGAP35/CD99	0.968875238520883
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	7/1031	44/9376	1.44678599770743	RFC1/HMGB1/PARP1/NEIL1/MBD4/TDG/PARP4	1.04409574855346
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	15/1031	108/9376	1.2630671408557	PNN/KPNA2/SRRM1/TPR/PHAX/XPO1/UPF3A/ACIN1/SUMO2/UPF2/SEC13/CASC3/RANBP17/IPO9/UBE2I	0.966467535365014
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	21/1031	158/9376	1.20870728922393	IGF1/DDIT4/LPIN2/SOS2/WNT5A/PIK3R1/EIF4B/PTEN/FZD2/WNT16/FZD7/AKT3/PIK3R3/FZD10/SEC13/PRKCA/RPS6KA2/ULK2/RICTOR/ATP6V1E1/MAPK1	0.929928609786137
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	11/1031	76/9376	1.31624891520751	FADS2/ACSL3/ANGPTL4/ACOX2/ACADM/SCD/CPT1A/CYP27A1/SCD5/CD36/ACOX1	0.9729626449394
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	19/1031	142/9376	1.21681397795112	IL1R1/SOCS1/RAC1/ITPR2/SOCS3/JAK1/PIK3R1/SQSTM1/IRF9/MAP2K6/AKT3/PIK3R3/TGFB1/TGFB2/NFATC2/ITPR3/CREB1/STAT1/MAPK1	0.915036283033993
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	15/1031	110/9376	1.24010228374923	IGF1/ANGPT1/EGFR/PIK3R1/EP300/CREBBP/CDKN1B/PLCG1/AKT3/PIK3R3/VEGFA/EGLN2/VHL/PRKCA/MAPK1	0.890324420862106
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	4/1031	23/9376	1.58157972420191	RFC1/MLH3/MSH6/MSH3	0.981520802053866
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	15/1031	112/9376	1.21795760011085	ITGB1/LAMA2/SOCS1/JAK1/ITGA6/LAMB1/GNAI1/XIAP/MAP2K6/AKT3/TGFB1/GNAI3/TGFB2/STAT1/MAPK1	0.815611904085993
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	26/1031	205/9376	1.15339594521066	CDK6/GADD45G/RAC1/JAK1/CD44/CIR1/USP7/SNW1/PSMD12/NCOR2/PIK3R1/HLA-E/CDKN1B/TAPBPL/EIF2AK2/IRF3/IRF9/TBK1/MAP2K6/AKT3/NEDD4/PIK3R3/RB1/RIPK1/POLK/STAT1	0.780520409961054
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	18/1031	138/9376	1.18618479315144	SOCS2/PPP1CB/SOCS1/SOCS3/SOS2/PHKA2/PIK3R1/PHKB/CALM1/PRKAG1/AKT3/PIK3R3/SHC2/PRKAG2/INPP5A/MAPK1/PPP1R3B/PRKACA	0.77445568335584
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	47/1031	388/9376	1.10160288779785	MME/COX7C/MT-ND1/CACNA1D/CSNK1A1/SLC39A7/ITPR2/AXIN2/SLC39A10/TUBA3E/MT-CO1/WNT5A/DKK2/PSMD12/PIK3R1/ATF4/COX7A1/ADAM10/CALM1/NDUFV3/EIF2AK2/CSNK2A2/FZD2/WNT16/TUBA3D/ATG14/MT-ND6/LRP1/FZD7/AKT3/MT-ND4L/PIK3R3/KLC1/MT-ATP8/FZD10/NDUFB1/ITPR3/RB1CC1/NDUFA1/ULK2/NDUFS1/NRBF2/NDUFC2/NDUFB4/MAPK1/ERN1/BACE1	0.718442777322888
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	33/1031	268/9376	1.11979385323624	COX7C/MT-ND1/GNAS/SLC39A7/ITPR2/SLC39A10/TUBA3E/SNCAIP/MT-CO1/PSMD12/ATF4/COX7A1/CALM1/GNAI1/NDUFV3/ADCY5/TUBA3D/MT-ND6/PLCG1/MT-ND4L/KLC1/MT-ATP8/GNAI3/UCHL1/NDUFB1/ITPR3/SLC18A2/NDUFA1/NDUFS1/NDUFC2/NDUFB4/PRKACA/ERN1	0.699346202286362
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	12/1031	89/9376	1.22616855022396	PLCL1/CACNA1D/GNG11/GNAI1/ADCY6/ADCY5/GNB5/GNAI3/GABRP/TRAK2/PRKCA/PRKACA	0.753513946695254
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	3/1031	17/9376	1.60483824955783	ACOX2/CYP46A1/CYP27A1	0.877305365036663
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	3/1031	17/9376	1.60483824955783	PAPSS1/SEPHS2/MTR	0.877305365036663
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	36/1031	300/9376	1.09129000969932	IGF1/CACNA1D/PDGFRA/ANGPT1/PAK2/GADD45G/IL1R1/RAC1/PDGFRB/EGFR/SOS2/PGF/ATF4/MAP4K4/CACNA1G/NF1/FGF9/MAP3K1/CACNA1H/PPM1B/TAOK1/MAP2K6/AKT3/VEGFA/TGFB1/MAP3K2/ARRB1/TGFB2/PRKCA/RPS6KA2/FGFR2/STK3/CACNB3/MAPK1/PRKACA/RASA1	0.564856898786458
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	6/1031	42/9376	1.29915477345157	GCLM/FTH1/SLC7A11/ACSL3/FTL/MAP1LC3A	0.682949331557819
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	3/1031	18/9376	1.51568056902683	TCN2/MTR/ABCD4	0.76971030295801
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	18/1031	144/9376	1.13676042677013	ATXN1/ITPR2/ATXN2/ATXN3/PSMD12/VLDLR/PIK3R1/AFG3L2/ATG14/AKT3/PIK3R3/PRKCA/ITPR3/RB1CC1/ULK2/NRBF2/RYR1/ERN1	0.581293672833846
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	14/1031	110/9376	1.15742879816595	IGF1/PGR/PIK3R1/GNAI1/ADCY6/ADCY5/AKT3/ANAPC5/PIK3R3/GNAI3/CPEB4/RPS6KA2/MAPK1/PRKACA	0.583762475581052
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	13/1031	102/9376	1.15904984690287	SLC12A2/GNAS/RAC1/ITPR2/KCNMA1/ADCY6/ADCY5/ATP1B2/PLA2G12A/ATP2B1/ATP1A1/PRKCA/ITPR3	0.567677388387053
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	6/1031	43/9376	1.2689418717434	PLPP3/PLA2G12A/PLPP1/ABCA1/CD36/APOB	0.621274914557054
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	7/1031	52/9376	1.22420353652167	LRPAP1/ANGPTL4/LRP1/CYP27A1/ABCA1/CD36/APOB	0.569829328931641
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	9/1031	69/9376	1.18618479315144	RAC1/SOS2/PIK3R1/PLCG1/MAP2K6/AKT3/PIK3R3/PRKCA/MAPK1	0.545589112731789
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	3/1031	19/9376	1.43590790749911	HPSE2/HGSNAT/IDS	0.668505574971928
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	9/1031	70/9376	1.16923929610642	SOCS3/APPL1/ACSL3/PRKAG1/AKT3/PRKAG2/CPT1A/CD36/PRKCQ	0.499540272718267
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	30/1031	254/9376	1.07410434025524	CACNA1D/NTRK3/GNAS/PDGFRA/MCOLN3/EDNRA/PDGFRB/STIM1/ITPR2/EGFR/PHKA2/ORAI3/PHKB/MCOLN2/CALM1/CACNA1G/FGF9/MYLK/CACNA1H/PLCG1/ORAI2/ATP2B1/VEGFA/TPCN1/PRKCA/NFATC2/ITPR3/FGFR2/RYR1/PRKACA	0.42084024991383
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	13/1031	105/9376	1.12593413699136	SMURF2/USP8/ATF4/CALCOCO2/SQSTM1/CSNK2A2/TOMM20/MAP1LC3A/TBK1/BNIP3L/VCP/HUWE1/RAB5A	0.456117389112606
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	13/1031	105/9376	1.12593413699136	ITPR2/PIK3R1/CALM1/IRF9/AKT3/PIK3R3/ARHGEF12/PYCARD/NFATC2/ITPR3/STAT1/MAPK1/MALT1	0.456117389112606
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	4/1031	28/9376	1.29915477345157	HACD3/HADHA/ACAA2/THEM4	0.557208074531222
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	7/1031	54/9376	1.17886266479865	BHMT2/GCLM/MTR/DNMT3A/AHCYL1/BHMT/AHCYL2	0.463301629603185
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	32/1031	275/9376	1.05822061546601	COX7C/MT-ND1/CREB3L2/CACNA1D/RAC1/ITPR2/TUBA3E/MT-CO1/PSMD12/PIK3R1/CREB5/ATF4/COX7A1/NDUFV3/CSNK2A2/TUBA3D/MT-ND6/MT-ND4L/PIK3R3/KLC1/MT-ATP8/CREB3L1/NDUFB1/ITPR3/NDUFA1/CREB1/NDUFS1/RYR1/NDUFC2/NDUFB4/MAPK1/PRKACA	0.344429532538799
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	5/1031	38/9376	1.19658992291592	QPRT/NAPRT/NT5E/ENPP3/SIRT1	0.426803444999935
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	6/1031	48/9376	1.13676042677013	ALDH7A1/HADHA/ACAA2/ACADM/ALDH3A2/HMGCL	0.333878610694634
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	6/1031	48/9376	1.13676042677013	CACNA1D/PIK3R1/ATP1B2/AKT3/PIK3R3/ATP1A1	0.333878610694634
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	14/1031	119/9376	1.06989216637188	CREB3L2/SOCS3/PIK3R1/CREB5/ATF4/XIAP/MAP2K6/AKT3/PIK3R3/CREB3L1/RIPK1/CREB1/ITCH/MAPK1	0.269692364670241
NA	NA	hsa04981	Folate transport and metabolism	4/1031	31/9376	1.17343011795626	BHMT2/MTR/ABCG2/BHMT	0.339951932146985
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	16/1031	138/9376	1.05438648280128	COX7C/MT-ND1/ATP6V0D1/MT-CO1/COX7A1/NDUFV3/MT-ND6/MT-ND4L/MT-ATP8/NDUFB1/NDUFA1/NDUFS1/NDUFC2/ATP6V1E1/NDUFB4/ATP6V0E2	0.226226428003303
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	22/1031	193/9376	1.03663127000799	ROCK2/RAC1/SOS2/PIK3R1/GNG11/ROCK1/PTK2/GNAI1/ADCY6/ADCY5/PREX1/PLCG1/GNB5/AKT3/PIK3R3/GNAI3/SHC2/ARRB1/GRK3/STAT1/MAPK1/PRKACA	0.180734115742558
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	3/1031	23/9376	1.18618479315144	MME/ANPEP/LNPEP	0.314220458347315
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3/1031	23/9376	1.18618479315144	CA4/ATP1B2/ATP1A1	0.314220458347315
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	4/1031	32/9376	1.13676042677013	IGBP1/ATG10/PPP2CB/ULK2	0.272377244467562
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	5/1031	41/9376	1.10903456270256	CHDH/ALDH7A1/GAMT/GCSH/BHMT	0.245923909159442
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	14/1031	122/9376	1.04358334260864	PAK2/SOS2/PIK3R1/DLG1/PLCG1/PPP2R5A/PPP2R2C/AKT3/PIK3R3/PPP2CB/NFATC2/MAPK1/MALT1/PRKCQ	0.17030896251839
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	19/1031	168/9376	1.02849752898249	SOCS2/PDGFRA/PIAS1/SOCS1/PDGFRB/SOCS3/JAK1/EGFR/SOS2/PIK3R1/EP300/FHL1/CREBBP/CNTFR/IRF9/STAM2/AKT3/PIK3R3/STAT1	0.131002924191918
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	12/1031	105/9376	1.03932381876126	GADD45G/IL1R1/ATM/PARP1/CSNK2A2/XIAP/ERC1/PLCG1/RIPK1/MALT1/PRKCQ/UBE2I	0.142425858244874
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	9/1031	78/9376	1.04931731701858	IP6K2/PIP5K1B/PIK3C2A/PTEN/INPP5F/PLCG1/SACM1L/IMPA1/INPP5A	0.153728281620301
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	3/1031	24/9376	1.13676042677013	XYLT1/EXT1/HS6ST1	0.235784699485813
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	13/1031	115/9376	1.02802682073124	CACNA1D/GNAS/ITPR2/GNG11/GNAI1/ADCY5/GNB5/GNAI3/PRKCA/ITPR3/SLC18A2/MAPK1/PRKACA	0.106290784889428
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	24/1031	216/9376	1.01045371268456	ROCK2/RAC1/VLDLR/PIK3R1/ATF4/PTK2/CALM1/IRF3/MIB1/PLCG1/POU2F1/TBK1/MAP2K6/AKT3/PIK3R3/PYCARD/PRKCA/NFATC2/ABCA1/CASP6/CD36/APOB/MAPK1/ERN1	0.0546325533627567
Organismal Systems	Digestive system	hsa04978	Mineral absorption	7/1031	61/9376	1.04358334260864	FTH1/HEPH/FTL/ATP1B2/ATP2B1/ATP1A1/CLCN2	0.12003166308791
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	4/1031	34/9376	1.06989216637188	POLR2A/POLR2B/POLR2J3/CRCP	0.143499315484388
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	8/1031	71/9376	1.02468545511673	RAC1/EGFR/ATP6V0D1/TJP1/ADAM10/PLCG1/ATP6V1E1/ATP6V0E2	0.0733861196299265
Human Diseases	Infectious disease: viral	hsa05162	Measles	15/1031	136/9376	1.00302390597364	CDK6/JAK1/RACK1/PIK3R1/CDKN1B/EIF2AK2/CD46/CSNK2A2/IRF3/IRF9/TBK1/AKT3/PIK3R3/ADAR/STAT1	0.0124854313724336
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	5/1031	44/9376	1.03341856979102	TMEM258/TUSC3/KRTCAP2/MAN1A1/B4GALNT4	0.0780959717193137
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	5/1031	44/9376	1.03341856979102	GTF2I/TAF7/GTF2F1/MNAT1/TAF15	0.0780959717193137
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	12/1031	109/9376	1.00118349513699	RAC1/JAK1/PIK3R1/IRF3/IRF9/TBK1/MAP2K6/AKT3/PIK3R3/RIPK1/STAT1/MAPK1	0.00436829485963234
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	7/1031	63/9376	1.01045371268456	PTGDS/HPGD/EPHX2/PLA2G12A/PTGR1/PTGR2/CBR1	0.029261584087259
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	14/1031	128/9376	0.99466537342386	PDE9A/GUCY1A2/NT5E/PAPSS1/ENPP3/PDE5A/ADCY6/ADCY5/NME3/PDE8A/XDH/PDE4C/ENTPD2/ENTPD4	-0.021359294255796
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	3/1031	26/9376	1.04931731701858	FADS2/PLA2G12A/ACOX1	0.0885079151382017
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	3/1031	26/9376	1.04931731701858	TCN2/ABCD4/APOB	0.0885079151382017
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	5/1031	45/9376	1.01045371268456	ABCG2/ABCA1/ABCB9/ABCD4/ABCA5	0.0247066874951677
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	2/1031	17/9376	1.06989216637188	CSAD/FMO5	0.10137714104046
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	11/1031	103/9376	0.971212791803603	GNAS/PIK3R1/GNAI1/PPP2R2C/AKT3/PIK3R3/PPP2CB/TGFB1/GNAI3/TGFB2/MAPK1	-0.10325470055083
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	8/1031	75/9376	0.970035564177174	IGF1/CDK6/GADD45G/ATM/TP53I3/PTEN/ZNF385A/PPM1D	-0.0915743226426612
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	4/1031	37/9376	0.983144152882271	PGM3/NAGK/PMM1/GFPT1	-0.0361079687763333
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	17/1031	160/9376	0.966246362754607	ITGB1/GLG1/SLITRK6/ITGA9/HLA-E/ITGA6/ITGA8/CD34/CDH2/CD99/LRRC4B/ITGAV/TIGIT/LRRC4/NRCAM/NECTIN3/PTPRS	-0.151360006352721
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	15/1031	142/9376	0.960642614171938	MGST3/IL1R1/RAC1/PIK3R1/GSTM2/PTK2/SUMO2/CALM1/SQSTM1/MAP2K6/AKT3/PIK3R3/VEGFA/BMPR2/ITGAV	-0.166102925551064
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	3/1031	28/9376	0.97436608008868	ATP6V0D1/ATP6V1E1/ATP6V0E2	-0.0477459443206465
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	4/1031	38/9376	0.957271938332738	PGM3/NAGK/PMM1/GFPT1	-0.0927640829563611
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	21/1031	200/9376	0.954878758486906	ITGB1/WASF2/ROCK2/PAK2/IL1R1/RAC1/MYH10/TUBA3E/TJP1/ROCK1/SEC24D/MYO5B/TUBA3D/CYFIP1/WASL/ARHGEF12/MYO10/PYCARD/SEC24A/RIPK1/MAPK1	-0.226710239896518
NA	NA	hsa04081	Hormone signaling	23/1031	219/9376	0.955086385962115	DIO2/IGF1/ADRA2C/RAMP2/GNAS/RAMP1/THRA/PIK3R1/GNG11/APPL1/HEPH/SMAD5/ESR1/GNAI1/ADCY6/ADCY5/SMAD4/GNB5/PIK3R3/OPRL1/GNAI3/ITGAV/PRKACA	-0.236387905840214
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	7/1031	68/9376	0.936155645575398	SOS2/PIK3R1/TCF7L2/TCF7L1/AKT3/PIK3R3/MAPK1	-0.185716533721942
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	34/1031	323/9376	0.957271938332738	SOX4/CDK6/PDGFRA/DDIT4/RDX/SOCS1/PDGFRB/FSCN1/CD44/EGFR/ATM/SOS2/PIK3R1/ROCK1/EP300/CREBBP/ZEB2/CDKN1B/PTEN/MMP16/PLCG1/EZH2/DICER1/PIK3R3/ZEB1/VEGFA/TGFB2/PRKCA/BMPR2/DNMT3A/SIRT1/HOXD10/MAPK1/UBE2I	-0.274675543844594
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	6/1031	59/9376	0.924822042118069	MGST3/GCLM/GPX7/GSTM2/ODC1/ANPEP	-0.203601176332655
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	7/1031	70/9376	0.909408341416101	LAMA2/RAC1/EIF4G2/SSPN/SNTB2/HLA-E/DMD	-0.267397601361719
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/1031	20/9376	0.909408341416101	LBR/SQLE	-0.142547597645916
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	5/1031	51/9376	0.891576805309903	PAFAH1B1/PLD3/PLPP3/PLA2G12A/PLPP1	-0.272888144129079
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	4/1031	41/9376	0.88722765016205	EGFR/VEGFA/RB1/MAPK1	-0.254354366448918
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	3/1031	31/9376	0.880072588467194	ALDH7A1/ALDH3A2/HSD17B14	-0.23507771169392
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	3/1031	31/9376	0.880072588467194	GCSH/HYI/CAT	-0.23507771169392
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	9/1031	91/9376	0.899414843158781	RAC1/SOS2/PIK3R1/IFITM1/AKT3/PIK3R3/NFATC2/MAPK1/MALT1	-0.338895217341894
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/1031	10/9376	0.909408341416101	PAPSS1	-0.100742548843657
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	5/1031	52/9376	0.874431097515482	IGF1/GNAS/ADCY6/ADCY5/PRKACA	-0.319142349614626
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	4/1031	42/9376	0.866103182301048	ALDH7A1/HADHA/CAT/ALDH3A2	-0.305677028282556
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	18/1031	180/9376	0.909408341416101	PPP1CB/SRSF5/SOCS3/JAK1/PIK3R1/HLA-E/HCFC2/SRSF6/TAPBPL/EIF2AK2/IRF3/IRF9/POU2F1/TBK1/SRSF4/AKT3/PIK3R3/STAT1	-0.431347000644418
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	24/1031	238/9376	0.917050428318757	RPS20/RPS11/RPL27A/RPL13A/RPL38/RPS29/RPL31/RPS27/RPL23/RPL15/JAK1/EGFR/PIK3R1/EIF2AK2/IRF3/IRF9/PLCG1/TBK1/PIK3R3/ADAR/PRKCA/STAT1/MAPK1/VWF	-0.455594895771625
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	25/1031	248/9376	0.916742279653327	ROCK2/GCC2/ACBD3/AHNAK/RALA/DYNC1I2/RAC1/TUBA3E/TCF7L2/DYNC1H1/TCF7L1/PIK3C2A/DYNLL2/TUBA3D/MAP2K6/AKT3/CYFIP1/KLC1/WASL/DCTN2/DYNC1LI2/PYCARD/RIPK1/RAB5A/MAPK1	-0.467051036772853
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/1031	22/9376	0.826734855832819	ALDH7A1/ALDH3A2	-0.28597341540962
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	5/1031	56/9376	0.811971733407233	HBS1L/CLK4/VCP/PYCARD/SEC22B	-0.496033491014623
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/1031	12/9376	0.757840284513417	VKORC1	-0.295028260419211
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/1031	12/9376	0.757840284513417	CD46	-0.295028260419211
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	18/1031	187/9376	0.875366317940632	TXNIP/NLRP1/ITPR2/JAK1/ERBIN/PKN2/XIAP/IRF3/IRF9/MAP1LC3A/TBK1/TP53BP1/PYCARD/ITPR3/RIPK1/STAT1/MAPK1/SUGT1	-0.605095472510627
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	7/1031	78/9376	0.816135691014449	ITGB1/CALM1/GNAI1/IRF3/GNAI3/PYCARD/MAPK1	-0.573128182561216
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	7/1031	78/9376	0.816135691014449	ITGB1/JAK1/MARCKSL1/TGFB1/TGFB2/STAT1/MAPK1	-0.573128182561216
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	10/1031	109/9376	0.834319579280827	IL1R1/JAK1/SMAD3/SMAD4/PLCG1/TGFB1/NFATC2/STAT1/MAPK1/PRKCQ	-0.611528436026256
Human Diseases	Substance dependence	hsa05034	Alcoholism	18/1031	191/9376	0.85703403903088	CREB3L2/GNAS/PPP1CB/SOS2/GNG11/CREB5/ATF4/CALM1/GNAI1/ADCY5/GNB5/GNAI3/CREB3L1/SHC2/SLC18A2/CREB1/MAPK1/PRKACA	-0.701635495027489
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	5/1031	59/9376	0.77068503509839	NT5E/ENPP3/NME3/TK2/ENTPD4	-0.621043693125784
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/1031	27/9376	0.673635808456371	HADHA/HMGCL	-0.596902784337774
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	4/1031	50/9376	0.727526673132881	LRP1/TGFB1/TGFB2/CD36	-0.678989551701082
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	6/1031	72/9376	0.757840284513417	DDX3X/IRF3/MAP3K1/TBK1/ADAR/RIPK1	-0.724995140158739
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	7/1031	83/9376	0.766970890350928	IRF3/TBK1/ADAR/PYCARD/RIPK1/ZDHHC1/ZCCHC3	-0.749502444749369
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/1031	15/9376	0.606272227610734	B3GALT4	-0.53639208027825
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/1031	28/9376	0.649577386725786	PCBD1/CBR1	-0.652699963172515
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	7/1031	85/9376	0.748924516460318	NT5E/ENPP3/NME3/XDH/ENTPD2/TK2/ENTPD4	-0.817305348377404
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	3/1031	41/9376	0.665420737621537	ATM/ABRAXAS1/RAD50	-0.754632642057278
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/1031	16/9376	0.568380213385063	A4GALT	-0.607330669419403
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	16/1031	181/9376	0.803896876389923	MRC2/JAK1/ATP6V0D1/EP300/CALM1/CREBBP/LAMP2/AKT3/TGFB1/TGFB2/ARHGEF12/CREB1/STAT1/RAB5A/MAPK1/MALT1	-0.936374832351577
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	7/1031	87/9376	0.731707860909506	COX7C/CACNA1D/MT-CO1/COX7A1/ATP1B2/ATP1A1/CACNB3	-0.883659383021374
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/1031	30/9376	0.606272227610734	MTR/ABCG2	-0.759181452026536
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/1031	17/9376	0.534946083185942	CA4	-0.674551082955744
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	4/1031	55/9376	0.661387884666255	PLPP3/B4GALT6/PLPP1/SPTLC1	-0.885226454167255
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	8/1031	100/9376	0.727526673132881	CD24/MME/IL1R1/CD44/ITGA6/CD34/ANPEP/CD36	-0.962820713452605
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/1031	18/9376	0.505226856342278	ACSL3	-0.738503657446232
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/1031	18/9376	0.505226856342278	FUCA1	-0.738503657446232
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	4/1031	56/9376	0.649577386725786	TMEM258/TUSC3/KRTCAP2/MAN1A1	-0.924442666747223
Organismal Systems	Digestive system	hsa04976	Bile secretion	7/1031	90/9376	0.70731759887919	GNAS/ADCY6/ADCY5/ATP1B2/ATP1A1/ABCG2/PRKACA	-0.980630337224332
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/1031	32/9376	0.568380213385063	HADHA/ACOX1	-0.859630310553653
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/1031	32/9376	0.568380213385063	XIAP/BIRC6	-0.859630310553653
NA	NA	hsa04382	Cornified envelope formation	19/1031	217/9376	0.796256151470319	S100A13/COL4A1/PCSK6/COL4A2/COL7A1/TJP1/ITGA6/DST/EPHX2/KRT18/KRT8/KRT19/PPP2R5A/PPP2R2C/DSP/COL4A5/DSG2/PPP2CB/SPTLC1	-1.06731384502906
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/1031	19/9376	0.478635969166369	GCSH	-0.799560538375489
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/1031	46/9376	0.593092396575718	FTH1/HEPH/FTL	-0.97237928743753
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	14/1031	168/9376	0.757840284513417	JAK1/FTH1/HMGB1/VPS4B/FTL/SQSTM1/PARP1/EIF2AK2/XIAP/IRF9/PYCARD/RIPK1/STAT1/CHMP3	-1.11320637202306
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	7/1031	95/9376	0.670090356832916	ANGPT1/ATP6V0D1/VEGFA/TGFB1/TGFB2/ATP6V1E1/ATP6V0E2	-1.1359552595038
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/1031	35/9376	0.519661909380629	PMM1/HSD17B14	-1.00065913375628
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	3/1031	49/9376	0.556780617193531	LFNG/GALNT17/POFUT2	-1.09332076510978
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/1031	36/9376	0.505226856342278	ENPP3/PGM2L1	-1.04540778679104
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/1031	37/9376	0.491572076441136	ASRGL1/GFPT1	-1.08913538789577
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/1031	37/9376	0.491572076441136	PNMT/HGD	-1.08913538789577
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	10/1031	133/9376	0.68376567023767	RAC1/SOS2/PIK3R1/HLA-E/PLCG1/PIK3R3/SHC2/PRKCA/NFATC2/MAPK1	-1.29101164186072
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/1031	23/9376	0.395394931050479	ABHD14A-ACY1	-1.02038022906579
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/1031	23/9376	0.395394931050479	GGPS1	-1.02038022906579
NA	NA	hsa04082	Neuroactive ligand signaling	16/1031	199/9376	0.731182586063197	ADRA2C/GNAS/GNG11/P2RY14/GNAI1/ADCY6/ADCY5/SLC1A2/GNB5/OPRL1/GNAI3/GRIA4/GABRP/PRKCA/SLC18A2/PRKACA	-1.34721022850149
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	4/1031	66/9376	0.551156570555213	SMAD3/TGFB1/TGFB2/STAT1	-1.2861564487302
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	2/1031	41/9376	0.443613825081025	GRIA4/GABRP	-1.25491091766564
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	6/1031	93/9376	0.58671505897813	JAK1/PLCG1/NFATC2/STAT1/MAPK1/PRKCQ	-1.40782502384817
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	5/1031	82/9376	0.554517281351281	MGST3/GSTM2/NME3/XDH/TK2	-1.42409267902065
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/1031	70/9376	0.519661909380629	MGST3/GSTM2/SULT1A1/CBR1	-1.4178044124817
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/1031	28/9376	0.324788693362893	A4GALT	-1.25765398202438
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	2/1031	44/9376	0.41336742791641	CPE/HLA-E	-1.37090369353191
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/1031	29/9376	0.313589083246931	CALM1	-1.30121439732465
Organismal Systems	Sensory system	hsa04742	Taste transduction	5/1031	86/9376	0.528725779893082	ADCY6/ENTPD2/ITPR3/PRKACA/ASIC2	-1.54318094608059
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/1031	30/9376	0.303136113805367	B3GALT4	-1.34368508925767
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/1031	30/9376	0.303136113805367	PLA2G12A	-1.34368508925767
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	5/1031	88/9376	0.516709284895512	F10/F3/CD46/SERPINA5/VWF	-1.60099687668622
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	2/1031	47/9376	0.386982272943022	ALDH7A1/ALDH3A2	-1.48083345096871
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/1031	33/9376	0.275578285277606	ABHD14A-ACY1	-1.46523422970037
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/1031	36/9376	0.252613428171139	GALNT17	-1.57915552197688
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/1031	36/9376	0.252613428171139	RFC1	-1.57915552197688
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/1031	37/9376	0.245786038220568	PRKCA	-1.61564909745549
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/1031	39/9376	0.233181626004128	HLA-E	-1.68664209445336
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3/1031	73/9376	0.37372945537648	MGST3/GSTM2/FMO5	-1.88805093328439
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3/1031	79/9376	0.345344939778266	MGST3/GSTM2/CBR1	-2.05379200852532
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	4/1031	94/9376	0.386982272943022	TBK1/ANAPC5/MAPK6/MAPK1	-2.09951015013071
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/1031	45/9376	0.202090742536911	HLA-E	-1.88580796780127
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	1/1031	46/9376	0.197697465525239	PSMD12	-1.91724696274215
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	3/1031	82/9376	0.332710368810769	HLA-E/TAPBPL/CREB1	-2.13315183458847
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	2/1031	67/9376	0.27146517654212	ALDH7A1/ALDH3A2	-2.10347813542736
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	8/1031	154/9376	0.472419917618754	QPRT/GCLM/NAPRT/VKORC1/NME3/PMM1/ALDH3A2/PPCS	-2.32026715946318
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/1031	68/9376	0.267473041592971	ALDH1A2/CYP26A1	-2.13084412551923
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/1031	50/9376	0.18188166828322	TGFB1	-2.03870891025498
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	1/1031	54/9376	0.168408952114093	HLA-E	-2.15404085633343
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	2/1031	75/9376	0.242508891044294	MTR/ABHD14A-ACY1	-2.31496883908009
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	10/1031	195/9376	0.466363252008257	RAC1/PIK3R1/HMGB1/PLCG1/AKT3/PIK3R3/CLCN5/PRKCA/MAPK1/VWF	-2.64679217006929
Genetic Information Processing	Translation	hsa03010	Ribosome	12/1031	222/9376	0.491572076441136	RPS20/RPS11/RPL27A/RPL13A/RPL38/RPS29/RPL31/RPS27/RPL23/RPL15/RACK1/MRPS5	-2.69464915691101
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/1031	66/9376	0.137789142638803	HSD11B2	-2.47065676272021
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	3/1031	116/9376	0.235191812435198	GCSH/CAT/ACOX1	-2.91325050351835
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	2/1031	99/9376	0.183718856851738	KRT18/KRT19	-2.86982479375144
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	6/1031	183/9376	0.298166669316754	XPO1/MPHOSPH10/CSNK2A2/XRN1/XRN2/UTP14C	-3.37002175571238
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	1/1031	100/9376	0.0909408341416101	ACKR3	-3.21228138073587
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	12/1031	298/9376	0.366204701241383	GDF7/IL1R1/GDF11/ACKR3/ACVRL1/TNFRSF19/IL16/CNTFR/TGFB1/TGFB2/BMPR2/RELL1	-3.90808370104832
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	12/1031	370/9376	0.294943245864681	ADRA2C/PGRMC1/EDN3/EDNRA/THRA/P2RY14/NR3C1/OPRL1/RXFP1/GRIA4/GABRP/S1PR3	-4.86363268465772
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	4/1031	449/9376	0.0810163333110112	CALM1/ARRB1/GRK3/PRKACA	-7.01422989632595