category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	14/584	63/9376	3.56773211567732	NSD1/SETD2/KMT2C/KMT2A/NSD3/NSD2/ASH1L/PLOD1/KMT5B/KMT2E/EZH2/ALDH7A1/EHMT1/EZH1	5.27015524191343
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	17/584	93/9376	2.93474738547651	ROCK2/SNAI2/SMURF2/WASF2/HEG1/SMAD4/IQGAP1/TCF7L2/EGFR/ARHGAP29/CTNNA2/EP300/CREBBP/AFDN/YES1/SMAD3/ROCK1	4.83247693156539
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	39/584	333/9376	1.88029125015426	CREB3L2/CDK6/COL4A1/ITGA9/JAK1/UBE3A/ATM/LAMA2/CHD4/CREB5/COL4A2/AXIN2/ITGB8/CSNK1A1/ITGB1/LLGL1/ATP6V0D1/PIK3R3/SOS2/LFNG/PTEN/TCF7L2/EGFR/PIK3R1/WNT16/ITGAV/IRF1/CDKN1B/DLG1/PTK2/CREB1/IRF3/EP300/CREBBP/HLA-E/NFX1/LAMB1/MAML2/GSK3B	4.21541618340767
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	15/584	83/9376	2.90146888925565	RYBP/RBBP4/EZH2/SCML1/MGA/SUZ12/EZH1/RBBP7/ASXL3/EP300/CREBBP/OGT/USP7/YAF2/PCGF3	4.48433990364473
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	19/584	122/9376	2.50033685156075	IGF1/CACNA1D/CREB3L2/ITPR2/GNAI1/SOCS2/CREB5/PIK3R3/SOS2/PIK3R1/ADCY5/MAPK8/PTK2/CREB1/EP300/CREBBP/GSK3B/PLCB1/ITPR1	4.29884876175307
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	17/584	106/9376	2.57482553631429	IGF1/CREB3L2/CREB5/PDGFRA/ZEB1/PIK3R3/SOS2/AR/PTEN/TCF7L2/EGFR/PIK3R1/CDKN1B/CREB1/EP300/CREBBP/GSK3B	4.20236466409225
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	16/584	98/9376	2.62119094213028	ITPR2/PIK3C2A/IP6K2/DGKB/IMPA1/PIK3R3/PTEN/INPP5F/PIK3R1/DGKD/PIKFYVE/PPIP5K2/SACM1L/DGKE/PLCB1/ITPR1	4.15784451305333
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	30/584	250/9376	1.92657534246575	DAB2/ZFYVE16/SMURF2/AGAP1/PDGFRA/RUFY2/CLTC/DNM1/ARFGEF1/USP8/ZFYVE9/EGFR/EPS15/ARFGAP3/RABEP1/HSPA8/VPS36/SPART/RAB11FIP2/SH3GLB1/PDCD6IP/WASHC2C/STAM2/ITCH/NEDD4/AP2B1/HLA-E/ARRB1/VPS35/SMAD3	3.82700238581976
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	19/584	133/9376	2.29354207436399	IGF1/PLK2/ATM/SMAD4/PIK3R3/SOS2/PTEN/EGFR/PIK3R1/TGFB2/GADD45G/CDKN1B/CAT/ATG12/MAPK8/EP300/CREBBP/USP7/SMAD3	3.87211391399447
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	16/584	103/9376	2.49394866338609	FUS/SRRM1/PNN/UPF3A/SMG1/PAPOLA/MSI2/PPP1CB/ACIN1/FIP1L1/HBS1L/CPSF2/PABPC4L/DDX39B/GSPT2/RNMT	3.92909363387541
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	25/584	203/9376	1.97719144341723	IGF1/ROCK2/COL4A1/ITGA9/PGF/PAK2/LAMA2/COL4A2/PDGFRA/DOCK1/ITGB8/PPP1CB/ITGB1/PIK3R3/SOS2/PTEN/EGFR/PIK3R1/ITGAV/BIRC2/MAPK8/PTK2/LAMB1/GSK3B/ROCK1	3.62760673684001
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	14/584	87/9376	2.58353015273185	AXIN2/SMAD4/PIK3R3/SOS2/TCF7L2/EGFR/PIK3R1/TGFB2/RALA/GADD45G/MSH6/MAPK8/GSK3B/SMAD3	3.82428019427661
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	11/584	62/9376	2.84843128590367	ATXN1/TLE4/TLE1/LFNG/SNW1/CTBP2/ITCH/EP300/CREBBP/MAML2/NUMB	3.76339029504439
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	20/584	155/9376	2.07158638974812	RASD1/CACNA1D/CREB3L2/CDK6/ITPR2/KMT2A/GNAI1/CREB5/AXIN2/USP8/TCF7L2/EGFR/WNT16/CACNA1H/ADCY5/CDKN1B/CREB1/GSK3B/PLCB1/ITPR1	3.46698728659291
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	22/584	178/9376	1.98430044635986	SFRP4/ROCK2/TLE4/DKK2/TLE1/DAAM2/AXIN2/SMAD4/CSNK1A1/DAAM1/SOX17/TCF7L2/WNT16/CHD8/CTBP2/MAPK8/EP300/CREBBP/GSK3B/PLCB1/SMAD3/ROR1	3.41695455381629
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	14/584	93/9376	2.41685078803948	CDK6/COL4A1/LAMA2/COL4A2/ITGB1/PIK3R3/PTEN/PIK3R1/ITGAV/BIRC2/GADD45G/CDKN1B/PTK2/LAMB1	3.53891097104891
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	32/584	308/9376	1.66803059953745	CREB3L2/MT-ND6/MT-ND1/POLR2J3/MT-CO1/CREB5/COX7C/MT-ND5/REST/PSMD12/CLTC/DNALI1/NDUFV3/SLC1A2/PSMA7/GRIA4/HIP1/TUBA3E/RCOR1/ATG2B/DCTN5/MAPK8/MT-ATP8/CREB1/ERN1/ULK2/EP300/CREBBP/AP2B1/PLCB1/ITPR1/POLR2A	3.07230395987025
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	10/584	59/9376	2.72115161365219	AXIN2/PIK3R3/SOS2/PTEN/TCF7L2/EGFR/PIK3R1/GADD45G/CTNNA2/GSK3B	3.41786817687388
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	17/584	133/9376	2.05211659285199	CACNA1D/CREB3L2/ITPR2/GNAI1/CREB5/PPP1CB/GRIA4/ADCY5/MAPK8/CREB1/SLC18A2/ARRB1/GSK3B/PLCB1/ITPR1/CLOCK/GNG11	3.14942619885767
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	25/584	227/9376	1.7681491762718	ROCK2/IL1R1/CREB3L2/CDK6/ITPR2/JAK1/GNAI1/CREB5/PDGFRA/PIK3R3/SOS2/EGFR/PIK3R1/ITGAV/ADCY5/PTK2/CREB1/TAPBPL/IRF3/HLA-E/GSK3B/PLCB1/ITPR1/ROCK1/GNG11	3.0193948225842
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	20/584	170/9376	1.88879935535858	CDK6/ARID1B/SMARCA2/AXIN2/GSTM2/SMAD4/CSNK1A1/PIK3R3/SOS2/SMARCC2/MGST3/PTEN/TCF7L2/EGFR/PIK3R1/WNT16/TGFB2/GADD45G/GSK3B/SMAD3	3.01398390218707
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	8/584	44/9376	2.91905354919054	CREB3L2/DYNC1I2/CREB5/DYNC1H1/NSF/DCTN5/CREB1/DYNC2H1	3.28832162605571
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	17/584	139/9376	1.96353602049867	PGR/GREB1/CREB3L2/ITPR2/FKBP5/GNAI1/CREB5/KRT18/PIK3R3/SOS2/EGFR/PIK3R1/HSPA8/ADCY5/CREB1/PLCB1/ITPR1	2.94956590975115
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	20/584	174/9376	1.84537868052275	SSR3/SEC31A/UBXN4/DNAJC10/DNAJC1/BCAP29/LMAN1/SEC23A/ERLEC1/HSPA8/UGGT2/UBXN2A/MBTPS1/DNAJA2/SELENOS/MAPK8/ERN1/SEC24D/ATXN3/SEC61B	2.90090176951422
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	9/584	56/9376	2.58023483365949	SCUBE2/SMURF2/CSNK1A1/EVC/CSNK1D/EFCAB7/GPR161/ARRB1/GSK3B	3.05672177156494
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	11/584	77/9376	2.29354207436399	CDK6/JAK1/SMAD4/PIK3R3/EGFR/PIK3R1/TGFB2/RALA/GADD45G/MAPK8/SMAD3	2.9373521788998
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	17/584	144/9376	1.89535768645358	IGF1/TBX3/JAK1/ZFHX3/AXIN2/SMAD4/REST/KAT6A/SMAD5/PIK3R3/PIK3R1/WNT16/SMARCAD1/RIF1/GSK3B/PCGF3/SMAD3	2.79047500304251
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	5/584	21/9376	3.82257012393999	DSEL/CHSY1/XYLT1/CSGALNACT2/CHST12	3.3371883118332
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	13/584	99/9376	2.10820534108205	GPCPD1/WASF2/DGKB/PDGFRA/PIK3R3/SOS2/PLPP3/EGFR/PIK3R1/DGKD/MAPK8/DGKE/SLC22A3	2.85681606890227
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	22/584	204/9376	1.7313994090787	IGF1/ROCK2/ITPR2/RDX/CD44/HPSE2/PPP1CB/ITGB1/IQGAP1/PIK3R3/SOS2/EGFR/PIK3R1/WNT16/TGFB2/ITGAV/HOXD10/DDX5/PTK2/FRS2/ITPR1/ROCK1	2.72198600431952
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	18/584	157/9376	1.84067707878894	LIMD1/SNAI2/GDF7/FRMD6/AXIN2/SMAD4/PPP1CB/LLGL1/TCF7L2/WNT16/CSNK1D/TGFB2/BIRC2/CTNNA2/DLG1/YWHAZ/GSK3B/SMAD3	2.73769679301539
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	16/584	134/9376	1.91699039051319	ROCK2/CACNA1D/KCNMB1/ITPR2/EDN3/PPP1R14A/RAMP2/GUCY1A2/RAMP1/CALCRL/PPP1CB/MYH10/ADCY5/PLCB1/ITPR1/ROCK1	2.75538584934132
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	18/584	158/9376	1.82902722385989	PDS5B/CDK6/PRKDC/ATM/ANAPC5/ATRX/SMAD4/WAPL/NIPBL/TGFB2/GADD45G/CDKN1B/YWHAZ/ESCO1/EP300/CREBBP/GSK3B/SMAD3	2.70848980944995
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	24/584	232/9376	1.66084081247048	ROCK2/ITGA9/WASF2/PAK2/RDX/ABI2/PDGFRA/DOCK1/ITGB8/CYFIP1/PPP1CB/ITGB1/MYH10/IQGAP1/PIK3R3/SOS2/EGFR/PIK3R1/ITGAV/PIKFYVE/ARHGEF7/PTK2/FGF9/ROCK1	2.62676343541772
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	11/584	80/9376	2.20753424657534	IGF1/JAK1/NRG2/PDGFRA/PIK3R3/SOS2/PTEN/EGFR/PIK3R1/NF1/GSK3B	2.79540420766609
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	23/584	224/9376	1.64848336594912	IL1R1/CREB3L2/XPO1/JAK1/ATM/ANAPC5/CREB5/SMAD4/MSX1/PIK3R3/PTEN/PIK3R1/TGFB2/ADCY5/GPS2/DLG1/MAPK8/ETS2/CREB1/EP300/CREBBP/HLA-E/SMAD3	2.53170480634844
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	10/584	73/9376	2.19928692062301	XPO1/AFF4/BICD1/CCNT2/PDCD6IP/EP300/CREBBP/MAP1B/PSIP1/MLLT3	2.65107026708653
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	15/584	130/9376	1.85247629083246	CREB3L2/COL4A1/GNAI1/CREB5/COL4A2/PIK3R3/SOS2/EGFR/PIK3R1/ADCY5/MAPK8/CREB1/ARRB1/PLCB1/GNG11	2.5224656613109
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	13/584	107/9376	1.95058251184227	CREB3L2/ITPR2/CREB5/PHKA2/PHKB/PPP4R3B/CREB1/CPT1A/PPARA/EP300/CREBBP/PLCB1/ITPR1	2.54866931355833
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	6/584	34/9376	2.83319903303787	RORB/DBP/CSNK1D/CREB1/NPAS2/CLOCK	2.75979846393403
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	10/584	75/9376	2.14063926940639	REV3L/ATM/TOP2B/GSTM2/PIK3R3/MGST3/PIK3R1/BIRC2/MSH6/XPA	2.55600883559173
NA	NA	hsa04519	Cadherin signaling	36/584	404/9376	1.43062525430625	ROCK2/LIMD1/PCDH9/KRT8/DAAM2/ABI2/AXIN2/PDGFRA/KRT18/ERBIN/CYFIP1/ADAM10/CSNK1A1/TAOK1/DAAM1/MPDZ/PPP1CB/GABRP/TCF7L2/EGFR/WNT16/LHFPL3/CTNNA2/YWHAZ/RERE/MAPK8/PTK2/LHFPL2/EP300/CREBBP/AFDN/PCDHGA5/GSK3B/PCDHGC3/ROCK1/DSG2	2.28030934932075
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	9/584	65/9376	2.22297154899895	CACNA1D/CREB3L2/ITPR2/CREB5/CACNA1H/ADCY5/CREB1/PLCB1/ITPR1	2.54989965889153
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	10/584	77/9376	2.08503824942181	CDK6/SMAD4/PIK3R3/SOS2/PIK3R1/TGFB2/GADD45G/CTBP2/CDKN1B/SMAD3	2.4638854269165
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	11/584	89/9376	1.98430044635986	ITPR2/GNAI1/PDGFRA/GUCY1A2/SOS2/EGFR/CSNK1D/TUBA3E/ADCY5/PLCB1/ITPR1	2.40454652552117
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	10/584	78/9376	2.05830698981384	ARHGAP10/WASF2/DOCK1/CLTC/DNM1/ITGB1/PIK3R3/PIK3R1/CTNNA2/PTK2	2.41886938051558
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	16/584	150/9376	1.71251141552511	AXIN2/SMAD4/CSNK1A1/PIK3R3/SOS2/TCF7L2/EGFR/PIK3R1/WNT16/TGFB2/GADD45G/CDKN1B/CTNNA2/FGF9/GSK3B/SMAD3	2.26714320428754
Organismal Systems	Immune system	hsa04611	Platelet activation	14/584	126/9376	1.78386605783866	ROCK2/ITPR2/GNAI1/GUCY1A2/PPP1CB/ITGB1/STIM1/PIK3R3/PIK3R1/ADCY5/VAMP8/PLCB1/ITPR1/ROCK1	2.28299251552931
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	13/584	115/9376	1.81488981536629	CACNA1D/CREB3L2/ITPR2/GNAI1/CREB5/PIK3R3/PIK3R1/ADCY5/CREB1/KCNQ3/PLCB1/ITPR1/GNG11	2.26603748681996
Organismal Systems	Endocrine system	hsa04924	Renin secretion	9/584	69/9376	2.09410363311495	CACNA1D/ITPR2/EDN3/GNAI1/GUCY1A2/ADCY5/CREB1/PLCB1/ITPR1	2.350857857141
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	12/584	105/9376	1.83483365949119	IGF1/CACNA1D/ITGA9/LAMA2/ITGB8/ITGB1/SNTB2/TGFB2/TTN/ITGAV/ADCY5/TPM3	2.21707064642104
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	13/584	117/9376	1.78386605783866	BPTF/SMARCA1/SMARCA5/RBBP4/ARID1B/CHD4/SMARCA2/MORF4L1/BAZ1B/RSF1/BAZ2B/SMARCC2/RBBP7	2.19887717074969
NA	NA	hsa04518	Integrin signaling	16/584	154/9376	1.66803059953745	IGF1/COL4A1/ITGA9/PGF/LAMA2/COL4A2/PDGFRA/ITGB8/ITGB1/PIK3R3/EGFR/PIK3R1/ITGAV/PTK2/LAMB1/GSK3B	2.15423153745347
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	20/584	205/9376	1.56632141663882	CREB3L2/CDK6/JAK1/UBE3A/DDX3X/CHD4/CREB5/ATP6V0D1/PIK3R3/PIK3R1/SNW1/CDKN1B/DLG1/YWHAZ/CREB1/IRF3/EP300/CREBBP/HLA-E/USP7	2.11290412777802
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	15/584	142/9376	1.69592899864943	PIAS1/UBE3A/BIRC6/SMURF2/ANAPC5/HERC2/TRIP12/UBE2Q2/BIRC2/CUL5/UBR5/ITCH/NEDD4/VHL/HUWE1	2.15358685942848
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	17/584	169/9376	1.61497933046932	BIRC6/STX7/DDIT4/PIK3R3/PTEN/PIK3R1/WDFY3/UVRAG/ATG2B/SH3GLB1/ATG12/CALCOCO2/MAPK8/ERN1/ULK2/VAMP8/ITPR1	2.0791844674584
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	15/584	144/9376	1.67237442922374	ATXN1/ITPR2/PSMD12/ATXN2/PIK3R3/PIK3R1/PSMA7/ATG2B/MAPK8/ERN1/ULK2/ATXN3/PLCB1/ITPR1/AFG3L2	2.09552457729542
Human Diseases	Cancer: specific types	hsa05218	Melanoma	9/584	73/9376	1.97935822856071	IGF1/CDK6/PDGFRA/PIK3R3/PTEN/EGFR/PIK3R1/GADD45G/FGF9	2.16490936065164
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	12/584	109/9376	1.76750031418876	CREB3L2/CREB5/PPP1CB/PIK3R3/PTEN/PIK3R1/MAPK8/CREB1/CPT1A/PPARA/OGT/GSK3B	2.07716239465031
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	11/584	97/9376	1.82064680129925	RASD1/CACNA1D/GNAI1/GUCY1A2/CACNA1H/GRIA4/ADCY5/CREB1/PLCB1/ITPR1/GNG11	2.09382211668962
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	10/584	86/9376	1.86683657215674	PAK2/NRG2/PIK3R3/SOS2/EGFR/PIK3R1/CDKN1B/MAPK8/PTK2/GSK3B	2.08126229649668
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	10/584	86/9376	1.86683657215674	CACNA1D/ITGA9/LAMA2/ITGB8/ITGB1/SNTB2/TCF7L2/ITGAV/CTNNA2/DSG2	2.08126229649668
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	12/584	110/9376	1.75143212951432	ZFYVE16/SMURF2/GDF7/SMAD4/LTBP1/SMAD5/ZFYVE9/TGFB2/EP300/CREBBP/SMAD3/ROCK1	2.04309319488281
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	15/584	148/9376	1.62717512032581	IGF1/PGR/CDK6/AXIN2/CSNK1A1/PIK3R3/SOS2/PTEN/TCF7L2/EGFR/PIK3R1/WNT16/GADD45G/FGF9/GSK3B	1.98204773018404
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	11/584	99/9376	1.78386605783866	IGF1/CACNA1D/ITGA9/LAMA2/ITGB8/ITGB1/SNTB2/TGFB2/TTN/ITGAV/TPM3	2.02070958051334
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	31/584	362/9376	1.37485809430107	IGF1/CREB3L2/CDK6/ANGPT1/COL4A1/ITGA9/JAK1/PGF/LAMA2/PKN2/DDIT4/CREB5/COL4A2/PDGFRA/ITGB8/ITGB1/PIK3R3/SOS2/PTEN/EGFR/PIK3R1/MAGI2/ITGAV/CDKN1B/YWHAZ/PTK2/FGF9/CREB1/LAMB1/GSK3B/GNG11	1.87460867927385
Human Diseases	Cancer: specific types	hsa05214	Glioma	9/584	76/9376	1.90122566690699	IGF1/CDK6/PDGFRA/PIK3R3/SOS2/PTEN/EGFR/PIK3R1/GADD45G	2.03304548827295
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	16/584	163/9376	1.57593075048323	CREB3L2/JAK1/DDX3X/CREB5/SMAD4/PIK3R3/SOS2/PIK3R1/TGFB2/YWHAZ/MAPK8/CREB1/IRF3/EP300/CREBBP/SMAD3	1.911664855092
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	8/584	65/9376	1.97597471022129	CACNA1D/ITPR2/PIK3R3/PIK3R1/CACNA1H/ARRB1/PLCB1/ITPR1	2.03491044637717
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	6/584	43/9376	2.24020388658809	ACSL3/ACAA2/ECI2/ALDH7A1/ACADM/CPT1A	2.10070420582535
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	11/584	101/9376	1.74854197748542	F3/COL4A1/COL4A2/SMAD4/PIK3R3/PIK3R1/TGFB2/CDKN1B/MAPK8/PLCB1/SMAD3	1.9492525451701
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	5/584	33/9376	2.43254462432545	STX7/STX2/VAMP8/STX18/VAMP3	2.12456575437509
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	9/584	78/9376	1.85247629083246	PIK3C2A/IP6K2/IMPA1/PTEN/INPP5F/PIKFYVE/PPIP5K2/SACM1L/PLCB1	1.94842216611726
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	9/584	78/9376	1.85247629083246	DHX36/CNOT4/XRN1/BTG3/DDX6/BTG2/PABPC4L/DCP2/DCP1A	1.94842216611726
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	16/584	166/9376	1.54745007426968	ROCK2/CACNA1D/ADRA2C/CREB3L2/KCNMB1/ITPR2/GNAI1/CREB5/GUCY1A2/GTF2I/PPP1CB/ADCY5/CREB1/PLCB1/ITPR1/ROCK1	1.83407448852963
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	12/584	115/9376	1.67528290649196	CREB3L2/ITPR2/GNAI1/MAFB/CREB5/EGFR/MMP16/ADCY5/CREB1/ARRB1/PLCB1/ITPR1	1.87781998432719
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	7/584	57/9376	1.97164143234799	HACD3/ACSL3/FADS2/ACAA2/ACADM/SCD/CPT1A	1.89629988870567
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	8/584	69/9376	1.86142545165773	CACNA1D/CREB3L2/CREB5/PPP1CB/GRIA4/ADCY5/CREB1/SLC18A2	1.85091131230898
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	17/584	184/9376	1.48332340678976	SEMA5A/ROCK2/GNAI1/GDF7/PAK2/ITGB1/PIK3R3/UNC5B/PIK3R1/EFNB2/LRIG2/SEMA3G/SRGAP2/PTK2/EPHA5/GSK3B/ROCK1	1.70643579985233
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	8/584	70/9376	1.83483365949119	PAK2/PIK3R3/SOS2/PIK3R1/TGFB2/VHL/EP300/CREBBP	1.80682324399788
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	18/584	201/9376	1.43774279288489	IGF1/HOXA10/FUS/HOXA11/KMT2A/NSD2/ATM/JMJD1C/ZEB1/WNT16/CCNT2/BIRC2/GADD45G/CDKN1B/DDX5/PTK2/HOXA9/MLLT3	1.61682203277344
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	5/584	37/9376	2.16956682710107	TCF7L2/TPR/GADD45G/TPM3/CCDC6	1.83706252581224
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	14/584	149/9376	1.50850418313873	CACNA1D/MT-ND6/ITPR2/MT-ND1/GNAI1/MT-ND5/GABRP/NDUFV3/GRIA4/ADCY5/MAPK8/PLCB1/ITPR1/GNG11	1.61252191593987
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	6/584	49/9376	1.96589320659771	CREB3L2/GNAI1/CREB5/ADCY5/CREB1/SLC18A2	1.74704618128777
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	19/584	217/9376	1.40571933590051	PGR/CACNA1D/CREB3L2/KPNA2/GNAI1/CREB5/GSTM2/PIK3R3/SOS2/MGST3/AR/EGFR/PIK3R1/ADCY5/PTGES3/FGF9/CREB1/PPARA/ARRB1	1.5584029635135
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	10/584	98/9376	1.63824433883142	CACNA1D/CREB3L2/ITPR2/CREB5/CACNA1H/ADCY5/CREB1/PRKD3/PLCB1/ITPR1	1.63689584812912
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	10/584	99/9376	1.62169641621696	IGF1/IL1R1/ITPR2/PPP1CB/PIK3R3/PIK3R1/ADCY5/MAPK8/PLCB1/ITPR1	1.60265633631888
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	18/584	205/9376	1.40968927497494	MT-ND6/MT-ND1/MT-CO1/COX7C/MT-ND5/PPP1CB/NDUFV3/PIK3R3/PTEN/PIK3R1/TGFB2/MAPK8/MT-ATP8/PPARA/PDK4/GSK3B/PLCB1/SMAD3	1.52852096842561
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	13/584	138/9376	1.51240817947191	ROCK2/WASF2/PKN2/DOCK1/ITGB1/PIK3R3/PIK3R1/MAPK8/ARHGEF7/PTK2/IRF3/GSK3B/ROCK1	1.56284115789453
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	6/584	50/9376	1.92657534246575	P4HA2/CKB/OAT/ALDH7A1/P4HA3/P4HA1	1.69303625183971
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	5/584	39/9376	2.05830698981384	BHMT2/MAT2A/ALDH7A1/MTR/GCSH	1.70682309509765
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	8/584	75/9376	1.71251141552511	CREB3L2/ITPR2/CREB5/DUOX1/ADCY5/CREB1/PLCB1/ITPR1	1.59663578344969
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	20/584	235/9376	1.36636549111046	CREB3L2/ZNF516/MT-ND6/MT-ND1/ARID1B/MT-CO1/CREB5/SMARCA2/COX7C/MT-ND5/ACSL3/NDUFV3/SOS2/SMARCC2/ADCY5/MT-ATP8/CREB1/CPT1A/FRS2/KDM3A	1.46588485653203
Cellular Processes	Cell motility	hsa04814	Motor proteins	17/584	194/9376	1.4068634373676	HOOK3/MYO9A/DYNC1I2/DNALI1/KIF2A/MYO5B/KIFAP3/MYH10/KIF27/TUBA3E/DYNC1H1/MYO15B/TPM3/DCTN5/DYNC2H1/MYO5A/STARD9	1.47580543937995
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	10/584	101/9376	1.58958361589584	CREB3L2/GNAI1/TCF7L2/WNT16/ADCY5/CREB1/EP300/CREBBP/GSK3B/PLCB1	1.53531451600913
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	9/584	89/9376	1.6235185470217	COL4A1/ITGA9/LAMA2/CD44/COL4A2/ITGB8/ITGB1/ITGAV/LAMB1	1.52319280295329
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	9/584	89/9376	1.6235185470217	PLCL1/CACNA1D/GNAI1/GABRP/TRAK2/GLS/ADCY5/NSF/GNG11	1.52319280295329
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	14/584	155/9376	1.45011047282369	STX7/DYNC1I2/ITGB1/ATP6V0D1/ITGAV/TUBA3E/DYNC1H1/PIKFYVE/DYNC2H1/STX18/HLA-E/MRC2/VAMP3/SEC61B	1.45627762891692
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	9/584	90/9376	1.60547945205479	IGF1/CREB3L2/CREB5/PIK3R3/PIK3R1/ADCY5/EHMT1/CAT/CREB1	1.48749168365545
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	11/584	116/9376	1.52243741143127	CACNA1D/ITPR2/GNAI1/SHANK2/SLC1A2/GRIA4/GLS/ADCY5/PLCB1/ITPR1/GNG11	1.45917033642061
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	10/584	103/9376	1.55871791461631	IL1R1/COL4A1/LAMA2/COL4A2/PIK3R3/PIK3R1/TGFB2/PTK2/LAMB1/PLCB1	1.46943135012113
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	7/584	65/9376	1.72897787144363	DGKB/LIPG/LPIN2/ALDH7A1/PLPP3/DGKD/DGKE	1.5199212338628
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	21/584	253/9376	1.33261140289133	ROCK2/IL1R1/ITPR2/WASF2/ATM/CD44/DOCK1/ITGB1/PIK3R3/EGFR/PIK3R1/UBE2V1/ATG12/CALCOCO2/MAPK8/PTK2/IRF3/GSK3B/PLCB1/ITPR1/ROCK1	1.38221874772894
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	14/584	157/9376	1.43163772794695	CACNA1D/CDK6/ITPR2/RBBP4/ATM/PPP1CB/PIK3R3/PTEN/PIK3R1/TGFB2/GADD45G/HLA-E/ITPR1/SMAD3	1.40564463259441
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	19/584	227/9376	1.34379337396657	MT-ND6/MT-ND1/MT-CO1/COX7C/MT-ND5/GSTM2/NDUFV3/PIK3R3/SOS2/MGST3/PTEN/EGFR/PIK3R1/CAT/MAPK8/MT-ATP8/PTK2/CBR1/PRKD3	1.35136242472011
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	8/584	79/9376	1.62580197676435	CLTC/DNM1/ATP6V0D1/SLC1A2/STX2/NSF/AP2B1/SLC18A2	1.43955175348099
Genetic Information Processing	Transcription	hsa03040	Spliceosome	20/584	243/9376	1.32138226506567	SF3B1/FUS/RBM25/TRA2B/DDX46/U2SURP/HNRNPU/SRSF4/ACIN1/CDC5L/HSPA8/SRSF5/SNW1/SF1/DDX5/SRSF10/DDX39B/HNRNPA3/DDX42/SRSF9	1.30817708461017
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	10/584	108/9376	1.48655504819888	SRRM1/PNN/XPO1/KPNA2/PHAX/UPF3A/ACIN1/TPR/DDX39B/RANBP17	1.31068723602649
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	13/584	149/9376	1.40075388434311	DGKB/PDGFRA/DNM1/PIK3R3/SOS2/PLPP3/EGFR/PIK3R1/RALA/ADCY5/DGKD/DGKE/PLCB1	1.27083403210665
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	3/584	21/9376	2.29354207436399	ENPP3/CSAD/PANK3	1.52938396634279
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	12/584	137/9376	1.40625937406259	ITPR2/ATM/CTSH/PTPN13/PIK3R3/PIK3R1/BIRC2/TUBA3E/GADD45G/MAPK8/ERN1/ITPR1	1.2345236582816
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	7/584	71/9376	1.58286706540614	SOCS2/PIK3R3/SOS2/PIK3R1/IRF1/MAPK8/GSK3B	1.27054111683159
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	11/584	125/9376	1.41282191780822	ROCK2/GNAI1/ORMDL1/PIK3R3/PTEN/PIK3R1/SPTLC1/MAPK8/S1PR3/PLCB1/ROCK1	1.19748928241769
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	16/584	196/9376	1.31059547106514	CDK6/ITPR2/JAK1/PIK3R3/TCF7L2/PIK3R1/MAPK8/CREB1/IRF3/EP300/CREBBP/HLA-E/PREX1/GSK3B/ITPR1/GNG11	1.13253083681526
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	9/584	99/9376	1.45952677459527	IGF1/PIK3R3/SOS2/EGFR/PIK3R1/ADCY5/CDKN1B/MAPK8/PTK2	1.18460309212441
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	8/584	86/9376	1.49346925772539	CACNA1D/CREB3L2/KCNMB1/PCLO/CREB5/ADCY5/CREB1/PLCB1	1.18481267816
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	5/584	47/9376	1.70795686388808	CACNA1D/SOCS2/PIK3R3/PIK3R1/MAPK8	1.25396784797663
Organismal Systems	Nervous system	hsa04730	Long-term depression	6/584	60/9376	1.60547945205479	IGF1/ITPR2/GNAI1/GUCY1A2/PLCB1/ITPR1	1.21257473899237
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	18/584	226/9376	1.27870044853922	ROCK2/CACNA1D/CREB3L2/EDN3/GNAI1/CREB5/PPP1CB/PIK3R3/PIK3R1/GRIA4/ADCY5/MAPK8/CREB1/PPARA/EP300/CREBBP/AFDN/ROCK1	1.09302365824224
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	17/584	212/9376	1.28741276815715	IGF1/SIPA1L1/ANGPT1/PGF/GNAI1/PDGFRA/ITGB1/PIK3R3/EGFR/PIK3R1/MAGI2/RALA/ADCY5/FGF9/AFDN/PRKD3/PLCB1	1.09088675745922
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	7/584	75/9376	1.49844748858447	IGF1/CDK6/ATM/PTEN/TP53I3/GADD45G/PPM1D	1.11694925737867
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	6/584	62/9376	1.55368979231109	IGF1/PIK3R3/PIK3R1/HSPA8/ADCY5/CAT	1.12730768340679
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	9/584	103/9376	1.40284612315467	MME/COL5A3/COL4A1/ELN/COL14A1/COL18A1/COL4A2/COL7A1/SLC7A8	1.05948763616208
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	2/584	13/9376	2.46996838777661	PRKDC/XRCC5	1.36684850372619
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	7/584	76/9376	1.47873107426099	ACSL3/FADS2/ANGPTL4/ACADM/SCD/CPT1A/PPARA	1.07995376337059
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	21/584	275/9376	1.22600249066002	CACNA1D/CREB3L2/MT-ND6/ITPR2/MT-ND1/MT-CO1/CREB5/COX7C/MT-ND5/PSMD12/NDUFV3/PIK3R3/PIK3R1/HSPA8/PSMA7/TUBA3E/MAPK8/MT-ATP8/CREB1/GSK3B/ITPR1	0.980354704128614
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	18/584	233/9376	1.24028455523546	COL5A3/COL4A1/ELN/ITGA9/LAMA2/DAAM2/COL4A2/ITGB8/LBR/DAAM1/ITGB1/FLNC/MYH10/SNTB2/TTN/ITGAV/TPM3/DSG2	0.957210996654768
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	4/584	38/9376	1.68997837058399	NAPRT/ENPP3/NT5E/QPRT	1.09836974669769
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	4/584	38/9376	1.68997837058399	IGF1/HSD11B2/PIK3R3/PIK3R1	1.09836974669769
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	24/584	323/9376	1.19292590864753	CDK6/SOX4/ATM/RDX/DDIT4/CD44/PDGFRA/DICER1/EZH2/ZEB1/PIK3R3/SOS2/PTEN/EGFR/PIK3R1/TGFB2/MMP16/HOXD10/GLS/ZEB2/CDKN1B/EP300/CREBBP/ROCK1	0.909376605490735
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	8/584	93/9376	1.38105759316541	CACNA1D/ITPR2/SOS2/EGFR/ADCY5/MAPK8/PLCB1/ITPR1	0.951779050015962
Human Diseases	Infectious disease: viral	hsa05162	Measles	11/584	136/9376	1.29854955680903	CDK6/JAK1/CD46/PIK3R3/PIK3R1/HSPA8/CDKN1B/ADAR/MAPK8/IRF3/GSK3B	0.903853660992781
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	10/584	122/9376	1.31596676397934	IGF1/CREB3L2/CREB5/RAB14/PIK3R3/PIK3R1/SCD/RAB2A/CREB1/CPT1A	0.905325581168473
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	14/584	180/9376	1.24870624048706	JAK1/PPP1CB/SRSF4/PIK3R3/PIK3R1/SRSF5/BIRC2/TAPBPL/POU2F1/HCFC2/IRF3/HLA-E/SRPK1/SRSF9	0.868303748591251
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	28/584	388/9376	1.15859341900861	MME/CACNA1D/MT-ND6/ITPR2/MT-ND1/DKK2/SLC39A10/MT-CO1/COX7C/MT-ND5/AXIN2/ADAM10/CSNK1A1/PSMD12/NDUFV3/PIK3R3/PIK3R1/WNT16/PSMA7/TUBA3E/ATG2B/MAPK8/MT-ATP8/ERN1/ULK2/GSK3B/PLCB1/ITPR1	0.822276189861015
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/584	27/9376	1.78386605783866	HACD3/FADS2/SCD	1.05120975820782
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	6/584	67/9376	1.43774279288489	ITPR2/PPP1CB/EP300/CREBBP/PLCB1/ITPR1	0.926729766423768
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	34/584	480/9376	1.13721461187215	CACNA1D/ATXN1/FUS/MT-ND6/ITPR2/MT-ND1/DKK2/MT-CO1/COX7C/MT-ND5/AXIN2/CSNK1A1/PSMD12/ATXN2/DNALI1/NDUFV3/NEFM/WNT16/PSMA7/GRIA4/HIP1/TUBA3E/ATG2B/DCTN5/CAT/SNCAIP/MAPK8/MT-ATP8/ERN1/ULK2/ATXN3/GSK3B/PLCB1/ITPR1	0.795374778163083
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	11/584	138/9376	1.27972999801469	IGF1/PGR/ITPR2/ANAPC5/PPP1CB/SLK/AR/ADCY5/YWHAZ/CPEB4/ITPR1	0.853174425212473
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	9/584	110/9376	1.31357409713574	IGF1/ANGPT1/PIK3R3/EGFR/PIK3R1/CDKN1B/VHL/EP300/CREBBP	0.852586785667038
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	9/584	110/9376	1.31357409713574	IGF1/PGR/GNAI1/ANAPC5/PIK3R3/PIK3R1/ADCY5/CPEB4/MAPK8	0.852586785667038
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	13/584	170/9376	1.22771958098308	ROCK2/CACNA1D/RDX/MPDZ/ITGB1/MYH10/LLGL1/TUBA3E/DLG1/MAPK8/NEDD4/AFDN/ROCK1	0.77221382661656
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	9/584	112/9376	1.29011741682975	JAK1/GNAI1/LAMA2/ITGB1/TGFB2/HSPA8/BIRC2/MAPK8/LAMB1	0.796034264831874
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	4/584	42/9376	1.52902804957599	FTH1/GCLM/ACSL3/SLC7A11	0.885559340832071
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	3/584	29/9376	1.66084081247048	LIMD1/RASSF2/FRMD6	0.918560902290047
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	6/584	71/9376	1.35674319891954	PDGFRA/PIK3R3/PTEN/EGFR/PIK3R1/GLS	0.777633407819136
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	11/584	144/9376	1.22640791476408	TRA2B/LPIN2/ALDH7A1/TCF7L2/ACADM/SCD/MAPK8/CPT1A/IRF3/PPARA/GSK3B	0.70562372580123
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/584	17/9376	1.88879935535858	PCDH9/MYH10	0.945282657062212
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	15/584	205/9376	1.17474106247912	CDK6/JAK1/CD44/PSMD12/PIK3R3/PIK3R1/SNW1/GADD45G/CDKN1B/MAPK8/TAPBPL/NEDD4/IRF3/HLA-E/USP7	0.651946229396993
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	9/584	116/9376	1.24563060935286	ROCK2/GNAI1/ITGB1/PIK3R3/PIK3R1/CTNNA2/PTK2/AFDN/ROCK1	0.686047536110954
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	6/584	73/9376	1.3195721523738	CDK6/PIK3R3/SOS2/EGFR/PIK3R1/GADD45G	0.706426641346952
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	3/584	31/9376	1.55368979231109	SPCS3/SRP54/SEC61B	0.795803661755809
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	19/584	268/9376	1.1382130443672	MT-ND6/ITPR2/MT-ND1/GNAI1/SLC39A10/MT-CO1/COX7C/MT-ND5/PSMD12/NDUFV3/PSMA7/TUBA3E/ADCY5/SNCAIP/MAPK8/MT-ATP8/ERN1/SLC18A2/ITPR1	0.591634023364482
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	17/584	238/9376	1.146771037182	IGF1/ANGPT1/PGF/PAK2/PDGFRA/PIK3R3/SOS2/EGFR/PIK3R1/RGL2/NF1/RALA/MAPK8/ETS2/FGF9/AFDN/GNG11	0.591087107688194
NA	NA	hsa04517	IgSF CAM signaling	21/584	299/9376	1.12759426398497	PAK2/RDX/MPDZ/ITGB1/MYH10/IQGAP1/PIK3R3/UNC5B/PIK3R1/MAGI2/CASK/EPB41L2/ERC1/TUBA3E/MAPK8/SRGAP2/PTK2/CLMP/AFDN/KCNQ3/GSK3B	0.5778881639805
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	8/584	104/9376	1.2349841938883	GPCPD1/PEMT/DGKB/LPGAT1/LPIN2/PLPP3/DGKD/DGKE	0.621036078509633
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	3/584	32/9376	1.50513698630137	ATG2B/ATG12/ULK2	0.737676528427365
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	3/584	32/9376	1.50513698630137	BIRC6/BIRC2/MAPK8	0.737676528427365
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	9/584	119/9376	1.21422815701623	CREB3L2/CREB5/PIK3R3/PIK3R1/BIRC2/IRF1/MAPK8/CREB1/ITCH	0.606126291503917
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	9/584	120/9376	1.2041095890411	KIDINS220/BEX3/PIK3R3/SOS2/PIK3R1/ZNF274/MAPK8/FRS2/GSK3B	0.579950036886695
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/584	19/9376	1.68997837058399	HPSE2/HGSNAT	0.775875761229489
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	9/584	122/9376	1.18437008758141	DIO2/MED13/PIK3R3/PIK3R1/ITGAV/EP300/CREBBP/GSK3B/PLCB1	0.528267449992407
NA	NA	hsa03272	Virion - Hepatitis viruses	4/584	48/9376	1.337899543379	EPCAM/EGFR/TGOLN2/PDCD6IP	0.604870183524653
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	4/584	48/9376	1.337899543379	CACNA1D/PIK3R3/PIK3R1/PLCB1	0.604870183524653
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	5/584	63/9376	1.27419004131333	PTGDS/PTGES3/PTGR1/CBR1/PTGR2	0.562762787708768
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	5/584	63/9376	1.27419004131333	POLR2J3/XPC/XPA/ERCC6/POLR2A	0.562762787708768
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	5/584	63/9376	1.27419004131333	AXIN2/TCF7L2/WNT16/GADD45G/GSK3B	0.562762787708768
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	3/584	34/9376	1.41659951651894	POLR2J3/CRCP/POLR2A	0.62717178279292
Organismal Systems	Digestive system	hsa04970	Salivary secretion	7/584	93/9376	1.20842539401974	SLC12A2/ITPR2/GUCY1A2/ADCY5/CST1/PLCB1/ITPR1	0.52059039651047
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	11/584	154/9376	1.146771037182	ROCK2/CACNA1D/ITPR2/GNAI1/GUCY1A2/PPP1CB/EGFR/ADCY5/PLCB1/ITPR1/ROCK1	0.473299871744104
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	4/584	49/9376	1.31059547106514	LFNG/GXYLT2/GALNT3/OGT	0.561785327759974
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	11/584	156/9376	1.13206884439761	CDK6/PIAS1/JAK1/PIK3R3/SOS2/EGFR/PIK3R1/YWHAZ/IRF3/PPARA/GSK3B	0.42869205867665
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	17/584	250/9376	1.09172602739726	VPS13C/MCOLN3/CTSH/CLTC/ATP6V0D1/LAPTM4B/MCOLN2/HGSNAT/TPCN1/BORCS7/PIKFYVE/ENTPD4/GPR155/OSBPL1A/VAMP8/AP2B1/VPS35	0.378852867762405
NA	NA	hsa04081	Hormone signaling	15/584	219/9376	1.0996434603115	IGF1/DIO2/ADRA2C/GNAI1/RAMP2/RAMP1/SMAD4/SMAD5/PIK3R3/PIK3R1/ITGAV/ADCY5/NPR3/PLCB1/GNG11	0.384540842270105
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	4/584	51/9376	1.25919957023905	SLC12A2/ATP6V0D1/KDELR3/SEC61B	0.478347123796327
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	11/584	158/9376	1.11773885902549	IGF1/DDIT4/LPIN2/PIK3R3/SOS2/PTEN/PIK3R1/WNT16/FNIP1/ULK2/GSK3B	0.384661071034619
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/584	22/9376	1.45952677459527	ASPA/ALDH7A1	0.556124080324407
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	3/584	37/9376	1.30174009626064	ASRGL1/ASPA/GLS	0.4739493379351
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	4/584	52/9376	1.2349841938883	LRPAP1/LIPG/ANGPTL4/ABCA1	0.437912570550767
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	20/584	300/9376	1.0703196347032	IGF1/CACNA1D/IL1R1/ANGPT1/PGF/PAK2/PDGFRA/TAOK1/SOS2/EGFR/TGFB2/CACNA1H/HSPA8/MAP4K4/NF1/GADD45G/MAPK8/FGF9/MAP3K12/ARRB1	0.319034912941909
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	6/584	83/9376	1.16058755570226	ACSL3/ECI2/FAR1/XDH/PEX1/CAT	0.37872256976359
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/584	53/9376	1.21168260532437	CLTC/DNM1/AP2B1/PLCB1	0.398284574683979
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	2/584	23/9376	1.3960690887433	MLH3/MSH6	0.490125865310053
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/584	23/9376	1.3960690887433	MME/LNPEP	0.490125865310053
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/584	23/9376	1.3960690887433	CA4/GLS	0.490125865310053
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	8/584	115/9376	1.11685527099464	CACNA1D/ITPR2/GNAI1/ADCY5/SLC18A2/PLCB1/ITPR1/GNG11	0.324949974356143
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	13/584	193/9376	1.08141102988147	ROCK2/GNAI1/PIK3R3/SOS2/PIK3R1/ADCY5/PTK2/PREX1/ARRB1/GSK3B/PLCB1/ROCK1/GNG11	0.294522062529335
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	4/584	54/9376	1.18924403855911	GCLM/BHMT2/MAT2A/MTR	0.359428706687211
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	4/584	54/9376	1.18924403855911	REV3L/RMI1/POLI/REV1	0.359428706687211
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	24/584	368/9376	1.04705181655747	FUS/MT-ND6/MT-ND1/MT-CO1/COX7C/NRG2/MT-ND5/SETX/PSMD12/ATXN2/DNALI1/NDUFV3/NEFM/SLC1A2/PSMA7/TPR/TUBA3E/ATG2B/DCTN5/CAT/MT-ATP8/ERN1/HNRNPA3/ULK2	0.237319998971834
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/584	24/9376	1.337899543379	XYLT1/EXT1	0.427158643536853
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	14/584	214/9376	1.05031366022276	ITPR2/GNAI1/PAK2/ATM/PIK3R3/PIK3R1/CUL5/MAPK8/PTK2/TAPBPL/IRF3/HLA-E/ITPR1/GNG11	0.191887143381452
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	5/584	72/9376	1.11491628614916	DDX3X/ADAR/ATG12/MAPK8/IRF3	0.252267440844844
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	11/584	168/9376	1.0512067840835	PIAS1/JAK1/SOCS2/PDGFRA/PIK3R3/SOS2/EGFR/PIK3R1/STAM2/EP300/CREBBP	0.172602749460817
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	13/584	200/9376	1.04356164383562	ROCK2/IL1R1/WASF2/PAK2/CYFIP1/ITGB1/MYO5B/MYH10/TUBA3E/MAPK8/SEC24D/MYO5A/ROCK1	0.160487339411431
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	14/584	216/9376	1.04058853373922	ROCK2/MIB1/PIK3R3/PIK3R1/HSPA8/ABCA1/MAPK8/PTK2/ERN1/POU2F1/IRF3/GSK3B/PLCB1/ITPR1	0.155535927555123
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	9/584	138/9376	1.04705181655747	SOCS2/PHKA2/PPP1CB/PIK3R3/SOS2/PIK3R1/PHKB/MAPK8/GSK3B	0.143507692530416
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	12/584	187/9376	1.03025419383195	TXNIP/ITPR2/JAK1/PKN2/NLRP1/ERBIN/BIRC2/ATG12/MAPK8/IRF3/PLCB1/ITPR1	0.107701185702363
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	4/584	59/9376	1.08846064546088	GNAI1/PIK3R3/PIK3R1/ADCY5	0.175665422283683
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	5/584	76/9376	1.056236481615	ITPR2/GNAI1/ADCY5/PLCB1/ITPR1	0.126862038468232
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	11/584	173/9376	1.02082508512155	CDK6/XPO1/KPNA2/JAK1/PIK3R3/PIK3R1/ADAR/CALCOCO2/IRF3/EP300/CREBBP	0.0712513910975913
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	10/584	157/9376	1.02259837710496	CD24/DOCK1/ADAM10/RAB14/ITGAV/ABCA1/PTK2/VPS8/CREB1/CPT1A	0.0735924721734289
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	10/584	157/9376	1.02259837710496	MT-CO1/COX7C/NDUFV3/PIK3R3/PIK3R1/MAPK8/ERN1/ITCH/PPARA/GSK3B	0.0735924721734289
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/584	28/9376	1.146771037182	HACD3/ACAA2	0.200451010125449
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	9/584	142/9376	1.01755739918966	IL1R1/ITPR2/JAK1/PIK3R3/PIK3R1/TGFB2/MAPK8/CREB1/ITPR1	0.0543322440277218
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/584	12/9376	1.337899543379	VKORC1	0.301853174424529
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/584	12/9376	1.337899543379	CD46	0.301853174424529
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	5/584	78/9376	1.02915349490692	GNAI1/ITGB1/IRF1/MAPK8/IRF3	0.0666333085239937
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	3/584	48/9376	1.00342465753425	ACAA2/ALDH7A1/ACADM	0.00613044104923631
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/584	31/9376	1.03579319487406	CSAD/ALDH7A1	0.051444610217255
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	2/584	31/9376	1.03579319487406	GCSH/CAT	0.051444610217255
NA	NA	hsa04981	Folate transport and metabolism	2/584	31/9376	1.03579319487406	BHMT2/MTR	0.051444610217255
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	15/584	248/9376	0.971056120194432	ROCK2/PIK3C2A/DYNC1I2/ACBD3/CYFIP1/GCC2/TCF7L2/BIRC2/RALA/TUBA3E/S100A10/DYNC1H1/DCTN5/MAPK8/DYNC2H1	-0.119053726223331
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	4/584	68/9376	0.944399677679291	PIK3R3/SOS2/TCF7L2/PIK3R1	-0.118591018878276
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	15/584	254/9376	0.948117786646532	CACNA1D/ITPR2/MCOLN3/PDGFRA/PHKA2/STIM1/EGFR/PHKB/MCOLN2/CACNA1H/TPCN1/ORAI2/FGF9/PLCB1/ITPR1	-0.216042175408744
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	6/584	103/9376	0.935230748769783	GNAI1/PIK3R3/PIK3R1/TGFB2/MAPK8/PLCB1	-0.170343505715065
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	9/584	154/9376	0.938267212239815	CACNA1D/CREB3L2/GNAI1/CREB5/PPP1CB/ADCY5/TPM3/CREB1/PLCB1	-0.199072794539642
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	14/584	238/9376	0.944399677679291	RPS20/JAK1/RPL31/RPL23A/RPL13A/RPS11/RPS27/PIK3R3/EGFR/PIK3R1/RPL38/ADAR/MAPK8/IRF3	-0.223917704324233
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	4/584	69/9376	0.930712725828866	PIK3R3/SOS2/PIK3R1/MAPK8	-0.148874867019091
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	8/584	138/9376	0.930712725828866	MT-ND6/MT-ND1/MT-CO1/COX7C/MT-ND5/NDUFV3/ATP6V0D1/MT-ATP8	-0.211325673810613
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	4/584	70/9376	0.917416829745597	ACSL3/MAPK8/CPT1A/PPARA	-0.178734038670208
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/584	16/9376	1.00342465753425	A4GALT	0.00353335633342854
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	7/584	122/9376	0.921176734785538	PAK2/PIK3R3/SOS2/PIK3R1/DLG1/MAPK8/GSK3B	-0.225848812359726
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	6/584	105/9376	0.917416829745597	SMURF2/USP8/CALCOCO2/MAPK8/USP15/HUWE1	-0.219316411811926
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	6/584	105/9376	0.917416829745597	ITPR2/PIK3R3/PIK3R1/IRF1/MAPK8/ITPR1	-0.219316411811926
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/584	35/9376	0.917416829745597	ENOSF1/PMM2	-0.126147052960171
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	8/584	140/9376	0.917416829745597	ITPR2/GNAI1/SMAD4/ADCY5/PLCB1/ITPR1/SMAD3/GNG11	-0.253724163050056
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	4/584	71/9376	0.904495465946363	ADAM10/ATP6V0D1/EGFR/MAPK8	-0.208182010205772
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/584	17/9376	0.944399677679291	CSAD	-0.0591337292269199
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/584	17/9376	0.944399677679291	MTR	-0.0591337292269199
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/584	17/9376	0.944399677679291	CA4	-0.0591337292269199
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	8/584	142/9376	0.904495465946363	IL1R1/GSTM2/PIK3R3/MGST3/PIK3R1/ITGAV/MAPK8/PTK2	-0.295543525205738
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	5/584	90/9376	0.89193302891933	JAK1/PIK3R3/PTEN/EGFR/PIK3R1	-0.265489968676563
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	3/584	55/9376	0.875716064757161	B4GALT6/PLPP3/SPTLC1	-0.238239247590296
Human Diseases	Substance dependence	hsa05032	Morphine addiction	5/584	91/9376	0.882131567063074	GNAI1/GABRP/ADCY5/ARRB1/GNG11	-0.291189341151594
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/584	37/9376	0.867826730840429	PNMT/HGD	-0.207607256003473
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	2/584	37/9376	0.867826730840429	PGM3/PMM2	-0.207607256003473
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	2/584	37/9376	0.867826730840429	HBB/PLCB1	-0.207607256003473
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/584	18/9376	0.89193302891933	ACSL3	-0.118273087277882
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/584	18/9376	0.89193302891933	MTR	-0.118273087277882
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	3/584	56/9376	0.860078277886497	CLK4/HBS1L/HSPA8	-0.270657098039496
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	7/584	128/9376	0.877996575342466	ENPP3/GUCY1A2/NT5E/XDH/ADCY5/ENTPD4/PDE9A	-0.358179988273006
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	2/584	38/9376	0.844989185291997	PGM3/PMM2	-0.24676018342738
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/584	19/9376	0.844989185291997	GCSH	-0.174308556598057
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	3/584	59/9376	0.816345484095658	ENPP3/NT5E/ENTPD4	-0.364701703481348
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	3/584	59/9376	0.816345484095658	GCLM/GSTM2/MGST3	-0.364701703481348
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/584	20/9376	0.802739726027397	LBR	-0.2275923946182
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	3/584	60/9376	0.802739726027397	PIK3R3/PIK3R1/PTK2	-0.395046973789369
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/584	41/9376	0.783160708319412	ALDH7A1/GCSH	-0.358608821962002
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	2/584	41/9376	0.783160708319412	ATM/ABRAXAS1	-0.358608821962002
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	2/584	41/9376	0.783160708319412	GABRP/GRIA4	-0.358608821962002
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	5/584	98/9376	0.819122169415712	WASF2/DOCK1/PIK3R3/PLPP3/PIK3R1	-0.463894705974393
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/584	42/9376	0.764514024787997	ALDH7A1/CAT	-0.3941885598525
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/584	43/9376	0.746734628862695	PLPP3/ABCA1	-0.428990455594953
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	4/584	82/9376	0.783160708319412	HSPA8/CREB1/TAPBPL/HLA-E	-0.50826686041951
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	2/584	44/9376	0.729763387297634	TAF7/GTF2I	-0.463053726706093
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	2/584	44/9376	0.729763387297634	CPE/HLA-E	-0.463053726706093
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	5/584	102/9376	0.786999731399409	SLC12A2/ITPR2/ADCY5/PLCB1/ITPR1	-0.557435872438709
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/584	23/9376	0.69803454437165	GLS	-0.37367490783789
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	4/584	85/9376	0.755519742143433	ENPP3/NT5E/XDH/ENTPD4	-0.583539487762267
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	2/584	46/9376	0.69803454437165	PSMD12/PSMA7	-0.529107087712997
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	5/584	105/9376	0.764514024787997	IL1R1/ATM/BIRC2/ERC1/GADD45G	-0.62538092151742
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	4/584	87/9376	0.738151472209101	CACNA1D/MT-CO1/COX7C/TPM3	-0.632373268676743
NA	NA	hsa04382	Cornified envelope formation	11/584	217/9376	0.813837510258191	PCSK6/S100A13/COL4A1/KRT8/DST/COL4A2/KRT18/COL7A1/S100A10/SPTLC1/DSG2	-0.715066180084223
NA	NA	hsa04082	Neuroactive ligand signaling	10/584	199/9376	0.806773593997384	ADRA2C/GNAI1/GABRP/SLC1A2/GRIA4/ADCY5/P2RY14/SLC18A2/PLCB1/GNG11	-0.710053169758708
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3/584	68/9376	0.708299758259468	CYP26A1/ALDH1A3/ALDH1A2	-0.622173171506319
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	4/584	88/9376	0.729763387297634	F3/CD46/F10/SERPINA5	-0.656406152926719
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/584	26/9376	0.617492096944152	FADS2	-0.503349339666991
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	5/584	109/9376	0.736458464245319	JAK1/PIK3R3/PIK3R1/MAPK8/IRF3	-0.713248655900064
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	5/584	109/9376	0.736458464245319	IL1R1/JAK1/SMAD4/MAPK8/SMAD3	-0.713248655900064
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/584	70/9376	0.688062622309198	GSTM2/MGST3/CBR1	-0.67512335933723
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	3/584	70/9376	0.688062622309198	LAMA2/SNTB2/HLA-E	-0.67512335933723
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	4/584	91/9376	0.705705253650459	PIK3R3/SOS2/PIK3R1/GSK3B	-0.727043629567518
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	2/584	50/9376	0.642191780821918	HBB/TGFB2	-0.653786323152767
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/584	28/9376	0.573385518590998	A4GALT	-0.582644269431304
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/584	28/9376	0.573385518590998	CBR1	-0.582644269431304
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/584	28/9376	0.573385518590998	ATP6V0D1	-0.582644269431304
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/584	51/9376	0.629599785119527	PAFAH1B1/PLPP3	-0.683565475352471
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	2/584	52/9376	0.617492096944152	IGF1/ADCY5	-0.712835260582638
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	4/584	94/9376	0.683182745555232	ANAPC5/MAPK8/MAPK6/GSK3B	-0.795609926199209
Human Diseases	Substance dependence	hsa05034	Alcoholism	9/584	191/9376	0.756508642329484	CREB3L2/GNAI1/CREB5/PPP1CB/SOS2/ADCY5/CREB1/SLC18A2/GNG11	-0.876211354215328
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	7/584	154/9376	0.729763387297634	NAPRT/GCLM/MAT2A/VKORC1/QPRT/PMM2/PANK3	-0.871445460823388
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/584	30/9376	0.535159817351598	PIGG	-0.657203131638758
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/584	30/9376	0.535159817351598	MTR	-0.657203131638758
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/584	31/9376	0.51789659743703	ALDH7A1	-0.692914441321299
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	3/584	78/9376	0.617492096944152	JAK1/ITGB1/TGFB2	-0.874261120272641
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	4/584	100/9376	0.642191780821918	CD24/MME/IL1R1/CD44	-0.927082033186608
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3/584	79/9376	0.609675741286631	GSTM2/MGST3/CBR1	-0.897875033828127
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	8/584	181/9376	0.709604177703777	JAK1/ATP6V0D1/TGFB2/MAPK8/CREB1/EP300/CREBBP/MRC2	-1.01672149879528
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	3/584	82/9376	0.587370531239559	GSTM2/MGST3/XDH	-0.967195027146525
Organismal Systems	Digestive system	hsa04978	Mineral absorption	2/584	61/9376	0.526386705591736	FTH1/MT1F	-0.956413272930524
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/584	36/9376	0.445966514459665	ENPP3	-0.858345329580686
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/584	36/9376	0.445966514459665	GALNT3	-0.858345329580686
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/584	39/9376	0.411661397962768	HLA-E	-0.94886448200749
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	2/584	66/9376	0.486508924865089	TGFB2/SMAD3	-1.07889268602338
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	1/584	41/9376	0.391580354159706	EGFR	-1.00620441416457
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	3/584	93/9376	0.51789659743703	JAK1/MAPK8/MAML2	-1.2041642175115
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	6/584	160/9376	0.602054794520548	ITGA9/ITGB8/ITGB1/ITGAV/GLG1/HLA-E	-1.30845941632715
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	3/584	95/9376	0.506993511175198	ANGPT1/ATP6V0D1/TGFB2	-1.24470167432158
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	1/584	44/9376	0.364881693648817	ALG11	-1.08828295216639
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/584	45/9376	0.356773211567732	ABCA1	-1.11469103265774
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/584	45/9376	0.356773211567732	HLA-E	-1.11469103265774
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/584	73/9376	0.439857384124601	GSTM2/MGST3	-1.23821698439263
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/584	46/9376	0.349017272185825	FTH1	-1.14065886956668
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/584	47/9376	0.341591372777616	ALDH7A1	-1.16620558607625
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	2/584	75/9376	0.428127853881279	MAT2A/MTR	-1.28148337297641
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	2/584	83/9376	0.38686251856742	ADAR/IRF3	-1.44599624529469
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	1/584	54/9376	0.297311009639777	HLA-E	-1.33460793233723
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	4/584	133/9376	0.482850963023998	PIK3R3/SOS2/PIK3R1/HLA-E	-1.54804394953151
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	1/584	56/9376	0.286692759295499	ALG11	-1.37978338790764
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/584	66/9376	0.243254462432545	HSD11B2	-1.58999302071191
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	1/584	67/9376	0.239623798814148	ALDH7A1	-1.60976553074731
Genetic Information Processing	Translation	hsa03010	Ribosome	7/584	222/9376	0.506232259656917	RPS20/RPL31/RPL23A/RPL13A/RPS11/RPS27/RPL38	-1.91885415864827
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	4/584	168/9376	0.382257012393999	FTH1/JAK1/BIRC2/MAPK8	-2.08222679922794
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	2/584	116/9376	0.276806802078413	GCSH/CAT	-2.01988226497283
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/584	86/9376	0.186683657215674	PLCB1	-1.95276098601838
Organismal Systems	Digestive system	hsa04976	Bile secretion	1/584	90/9376	0.178386605783866	ADCY5	-2.01847162100857
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	1/584	99/9376	0.162169641621696	KRT18	-2.15982286143129
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	1/584	100/9376	0.160547945205479	ACKR3	-2.17502247295848
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	8/584	298/9376	0.431001195182495	IL1R1/GDF7/GDF11/ACKR3/TGFB2/ACVRL1/TNFRSF19/IL16	-2.572602095433
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	3/584	183/9376	0.263193352795868	XPO1/XRN1/MPHOSPH10	-2.59417143022101
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	3/584	195/9376	0.246996838777661	PIK3R3/PIK3R1/PLCB1	-2.73852893169183
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	8/584	370/9376	0.347130692336172	ADRA2C/EDN3/PGRMC1/CALCRL/GABRP/GRIA4/P2RY14/S1PR3	-3.30224556084954
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/584	449/9376	0.0357567806693718	ARRB1	-5.39641348295659