ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0042393 histone binding 47/1255 247/18639 0.190283400809717 2.82604964756359 7.32960425308553e-11 8.18716795069654e-08 GO:0008094 ATP-dependent activity, acting on DNA 40/1255 210/18639 0.19047619047619 2.82891291974957 1.83330461054136e-09 9.63223122597381e-07 GO:0003712 transcription coregulator activity 70/1255 495/18639 0.141414141414141 2.10025353132923 2.58699137671633e-09 9.63223122597381e-07 GO:0004386 helicase activity 30/1255 155/18639 0.193548387096774 2.87454054748747 1.32193269903585e-07 3.69149706205762e-05 GO:0140658 ATP-dependent chromatin remodeler activity 30/1255 158/18639 0.189873417721519 2.81996066367442 2.05224306047258e-07 4.58471099709575e-05 GO:0140097 catalytic activity, acting on DNA 48/1255 336/18639 0.142857142857143 2.12168468981218 6.13780336869495e-07 0.000114265439380538 GO:0003714 transcription corepressor activity 34/1255 204/18639 0.166666666666667 2.47529880478088 8.17811971066768e-07 0.00013049942452594 GO:0140034 methylation-dependent protein binding 18/1255 76/18639 0.236842105263158 3.51752988047809 2.12161288938015e-06 0.000296230199679704 GO:0061775 cohesin loader activity 27/1255 153/18639 0.176470588235294 2.62090461682681 3.5793351764458e-06 0.000444235265787773 GO:0035064 methylated histone binding 17/1255 74/18639 0.22972972972973 3.4118983525358 6.30604562363424e-06 0.000599595311000007 GO:0003689 DNA clamp loader activity 27/1255 160/18639 0.16875 2.50624003984064 8.50387722195146e-06 0.000599595311000007 GO:0000510 H3-H4 histone complex chaperone activity 26/1255 151/18639 0.172185430463576 2.55726234136302 8.54764111388699e-06 0.000599595311000007 GO:0140584 chromatin extrusion motor activity 26/1255 151/18639 0.172185430463576 2.55726234136302 8.54764111388699e-06 0.000599595311000007 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 26/1255 151/18639 0.172185430463576 2.55726234136302 8.54764111388699e-06 0.000599595311000007 GO:0140849 ATP-dependent H2AZ histone chaperone activity 26/1255 151/18639 0.172185430463576 2.55726234136302 8.54764111388699e-06 0.000599595311000007 GO:0003713 transcription coactivator activity 37/1255 256/18639 0.14453125 2.14654818227092 8.86698898872317e-06 0.000599595311000007 GO:0015616 DNA translocase activity 26/1255 152/18639 0.171052631578947 2.54043824701195 9.66223419695624e-06 0.000599595311000007 GO:0140674 ATP-dependent histone chaperone activity 26/1255 152/18639 0.171052631578947 2.54043824701195 9.66223419695624e-06 0.000599595311000007 GO:0016887 ATP hydrolysis activity 51/1255 417/18639 0.122302158273381 1.81640631717733 2.56949317069503e-05 0.00151059151140334 GO:0045296 cadherin binding 43/1255 334/18639 0.12874251497006 1.91205716057924 3.24307253975861e-05 0.00181125601345518 GO:0140030 modification-dependent protein binding 27/1255 173/18639 0.15606936416185 2.31790986343643 3.61935087030843e-05 0.0019251499629212 GO:0140713 histone chaperone activity 26/1255 164/18639 0.158536585365854 2.35455252162083 3.80868353109134e-05 0.00193377250192229 GO:0004674 protein serine/threonine kinase activity 51/1255 433/18639 0.117782909930716 1.74928737705069 6.92054564999458e-05 0.00336097803958433 GO:0046975 histone H3K36 methyltransferase activity 6/1255 13/18639 0.461538461538462 6.85467361323935 0.000104664953780735 0.00487128139054504 GO:0140597 protein carrier chaperone 27/1255 188/18639 0.143617021276596 2.13297024667288 0.000154454003776577 0.00690100488873747 GO:0015631 tubulin binding 45/1255 385/18639 0.116883116883117 1.73592383711906 0.000215097031352539 0.00924089938541486 GO:0140938 histone H3 methyltransferase activity 11/1255 47/18639 0.234042553191489 3.47595151309655 0.000225993459355147 0.00934943311480368 GO:0031490 chromatin DNA binding 20/1255 128/18639 0.15625 2.32059262948207 0.000349876843966254 0.0137172494319051 GO:0031267 small GTPase binding 35/1255 283/18639 0.123674911660777 1.83679416609182 0.000367597290834906 0.0137172494319051 GO:0106310 protein serine kinase activity 42/1255 361/18639 0.116343490304709 1.72790941497169 0.000379029826616387 0.0137172494319051 GO:0036408 histone H3K14 acetyltransferase activity 8/1255 28/18639 0.285714285714286 4.24336937962436 0.000380693583159408 0.0137172494319051 GO:0030695 GTPase regulator activity 53/1255 489/18639 0.10838445807771 1.60970351721947 0.000413068458381261 0.0144186708753709 GO:0060589 nucleoside-triphosphatase regulator activity 53/1255 490/18639 0.108163265306122 1.60641840800065 0.000433722635344553 0.014680854050905 GO:0010484 histone H3 acetyltransferase activity 8/1255 29/18639 0.275862068965517 4.09704629756835 0.000494958287228918 0.0162608354951383 GO:0043995 histone H4K5 acetyltransferase activity 8/1255 30/18639 0.266666666666667 3.9604780876494 0.000635487239517538 0.0191848445011105 GO:0043996 histone H4K8 acetyltransferase activity 8/1255 30/18639 0.266666666666667 3.9604780876494 0.000635487239517538 0.0191848445011105 GO:0043997 histone H4K12 acetyltransferase activity 8/1255 30/18639 0.266666666666667 3.9604780876494 0.000635487239517538 0.0191848445011105 GO:0140104 molecular carrier activity 31/1255 249/18639 0.124497991967871 1.84901838429415 0.000692301888397136 0.0203500318247263 GO:0046332 SMAD binding 14/1255 79/18639 0.177215189873418 2.63196328609612 0.000734492833398949 0.0210366280745289 GO:0008017 microtubule binding 33/1255 276/18639 0.119565217391304 1.77575783821237 0.00096229555545294 0.0256906849032708 GO:0061749 forked DNA-dependent helicase activity 10/1255 47/18639 0.212765957446809 3.15995592099686 0.00096598815213731 0.0256906849032708 GO:1990518 single-stranded 3'-5' DNA helicase activity 10/1255 47/18639 0.212765957446809 3.15995592099686 0.00096598815213731 0.0256906849032708 GO:0009378 four-way junction helicase activity 10/1255 48/18639 0.208333333333333 3.0941235059761 0.00114768327759721 0.0284880493572464 GO:0036121 double-stranded DNA helicase activity 10/1255 48/18639 0.208333333333333 3.0941235059761 0.00114768327759721 0.0284880493572464 GO:0043138 3'-5' DNA helicase activity 10/1255 48/18639 0.208333333333333 3.0941235059761 0.00114768327759721 0.0284880493572464 GO:0003678 DNA helicase activity 13/1255 74/18639 0.175675675675676 2.60909874017444 0.00122004047924376 0.0289954301130911 GO:0031491 nucleosome binding 13/1255 74/18639 0.175675675675676 2.60909874017444 0.00122004047924376 0.0289954301130911 GO:0005096 GTPase activator activity 32/1255 271/18639 0.118081180811808 1.7537172343835 0.00140063056319626 0.032593840397713 GO:0042054 histone methyltransferase activity 12/1255 67/18639 0.17910447761194 2.66002259618243 0.00156243627233635 0.0356171697183612 GO:0070063 RNA polymerase binding 11/1255 59/18639 0.186440677966102 2.76897832399217 0.00172946691243973 0.0386362908239036 GO:0010485 histone H4 acetyltransferase activity 8/1255 35/18639 0.228571428571429 3.39469550369949 0.00189256581261973 0.0414509022097301 GO:0016279 protein-lysine N-methyltransferase activity 12/1255 69/18639 0.173913043478261 2.58292049194526 0.00202903291997651 0.0429717605921429 GO:0008170 N-methyltransferase activity 15/1255 98/18639 0.153061224489796 2.27323359622734 0.00226209636144111 0.0429717605921429 GO:0001223 transcription coactivator binding 9/1255 44/18639 0.204545454545455 3.03786671495835 0.00229320250591569 0.0429717605921429 GO:0016278 lysine N-methyltransferase activity 12/1255 70/18639 0.171428571428571 2.54602162777462 0.00230186440001517 0.0429717605921429 GO:0051020 GTPase binding 35/1255 315/18639 0.111111111111111 1.65019920318725 0.00245491836312429 0.0429717605921429 GO:0051018 protein kinase A binding 10/1255 53/18639 0.188679245283019 2.80222506201609 0.00252045108141125 0.0429717605921429 GO:0032931 histone H3K56 acetyltransferase activity 6/1255 22/18639 0.272727272727273 4.0504889532778 0.00269294829136079 0.0429717605921429 GO:0043992 histone H3K9 acetyltransferase activity 6/1255 22/18639 0.272727272727273 4.0504889532778 0.00269294829136079 0.0429717605921429 GO:0043993 histone H3K18 acetyltransferase activity 6/1255 22/18639 0.272727272727273 4.0504889532778 0.00269294829136079 0.0429717605921429 GO:0043994 histone H3K23 acetyltransferase activity 6/1255 22/18639 0.272727272727273 4.0504889532778 0.00269294829136079 0.0429717605921429 GO:0043999 histone H2AK5 acetyltransferase activity 6/1255 22/18639 0.272727272727273 4.0504889532778 0.00269294829136079 0.0429717605921429 GO:0044012 histone H2AK9 acetyltransferase activity 6/1255 22/18639 0.272727272727273 4.0504889532778 0.00269294829136079 0.0429717605921429 GO:0044014 histone H2BK5 acetyltransferase activity 6/1255 22/18639 0.272727272727273 4.0504889532778 0.00269294829136079 0.0429717605921429 GO:0044015 histone H2BK12 acetyltransferase activity 6/1255 22/18639 0.272727272727273 4.0504889532778 0.00269294829136079 0.0429717605921429 GO:0044016 histone H3K4 acetyltransferase activity 6/1255 22/18639 0.272727272727273 4.0504889532778 0.00269294829136079 0.0429717605921429 GO:0044017 histone H3K27 acetyltransferase activity 6/1255 22/18639 0.272727272727273 4.0504889532778 0.00269294829136079 0.0429717605921429 GO:0044018 histone H3K36 acetyltransferase activity 6/1255 22/18639 0.272727272727273 4.0504889532778 0.00269294829136079 0.0429717605921429 GO:0046972 histone H4K16 acetyltransferase activity 6/1255 22/18639 0.272727272727273 4.0504889532778 0.00269294829136079 0.0429717605921429 GO:0140908 histone H3K122 acetyltransferase activity 6/1255 22/18639 0.272727272727273 4.0504889532778 0.00269294829136079 0.0429717605921429 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 49/1255 484/18639 0.101239669421488 1.50359059629252 0.00281919691209375 0.0443527176170242 GO:0140297 DNA-binding transcription factor binding 49/1255 488/18639 0.100409836065574 1.49126608320815 0.00331840055941257 0.0514812975675534 GO:0044013 histone H2B acetyltransferase activity 6/1255 23/18639 0.260869565217391 3.87438073791789 0.00343854609053708 0.0526144655223276 GO:0061733 protein-lysine-acetyltransferase activity 9/1255 47/18639 0.191489361702128 2.84396032889718 0.00367712440619073 0.0555047021853385 GO:0001216 DNA-binding transcription activator activity 49/1255 491/18639 0.09979633401222 1.48215447781177 0.00374123365860105 0.0557194399554317 GO:0031625 ubiquitin protein ligase binding 33/1255 302/18639 0.109271523178808 1.62287802432653 0.00415570949416392 0.0604098627928945 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 37/1255 349/18639 0.106017191977077 1.57454537152251 0.00416433252914313 0.0604098627928945 GO:0032266 phosphatidylinositol-3-phosphate binding 9/1255 48/18639 0.1875 2.78471115537849 0.00426084158971231 0.0604204079541944 GO:0015278 intracellularly gated calcium channel activity 5/1255 17/18639 0.294117647058824 4.36817436137802 0.0042908335666588 0.0604204079541944 GO:0043998 histone H2A acetyltransferase activity 6/1255 24/18639 0.25 3.71294820717131 0.00432733449985278 0.0604204079541944 GO:0017116 single-stranded DNA helicase activity 10/1255 58/18639 0.172413793103448 2.56065393598022 0.00497457557571177 0.0686000113341982 GO:0141003 histone H2AX kinase activity 37/1255 354/18639 0.104519774011299 1.55230603011682 0.00524528589652785 0.0714510286148976 GO:0001727 lipid kinase activity 8/1255 41/18639 0.195121951219512 2.89791079584103 0.00536962897379466 0.0722635610087787 GO:0140996 histone H3 kinase activity 37/1255 357/18639 0.103641456582633 1.53926144162844 0.00600113333499261 0.0798007849426993 GO:0044389 ubiquitin-like protein ligase binding 34/1255 322/18639 0.105590062111801 1.56820172725248 0.00621132852976256 0.0805073346122375 GO:0004402 histone acetyltransferase activity 8/1255 42/18639 0.19047619047619 2.82891291974957 0.00625000420716241 0.0805073346122375 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 10/1255 60/18639 0.166666666666667 2.47529880478088 0.00636595307404684 0.0805073346122375 GO:0034452 dynactin binding 4/1255 12/18639 0.333333333333333 4.95059760956175 0.00653736996462577 0.0805073346122375 GO:0035497 cAMP response element binding 4/1255 12/18639 0.333333333333333 4.95059760956175 0.00653736996462577 0.0805073346122375 GO:0034237 protein kinase A regulatory subunit binding 6/1255 26/18639 0.230769230769231 3.42733680661967 0.00659603039824226 0.0805073346122375 GO:0050681 nuclear androgen receptor binding 6/1255 26/18639 0.230769230769231 3.42733680661967 0.00659603039824226 0.0805073346122375 GO:0035173 histone kinase activity 37/1255 360/18639 0.102777777777778 1.52643426294821 0.00684658037648391 0.0805073346122375 GO:0019905 syntaxin binding 10/1255 61/18639 0.163934426229508 2.43472013585004 0.00716624942970755 0.0805073346122375 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 27/1255 243/18639 0.111111111111111 1.65019920318725 0.00719727678323785 0.0805073346122375 GO:0004676 3-phosphoinositide-dependent protein kinase activity 27/1255 245/18639 0.110204081632653 1.63672818928368 0.00800028123720533 0.0805073346122375 GO:0004711 ribosomal protein S6 kinase activity 27/1255 245/18639 0.110204081632653 1.63672818928368 0.00800028123720533 0.0805073346122375 GO:0035175 histone H3S10 kinase activity 27/1255 245/18639 0.110204081632653 1.63672818928368 0.00800028123720533 0.0805073346122375 GO:0035979 histone H2AXS139 kinase activity 27/1255 245/18639 0.110204081632653 1.63672818928368 0.00800028123720533 0.0805073346122375 GO:0044022 histone H3S28 kinase activity 27/1255 245/18639 0.110204081632653 1.63672818928368 0.00800028123720533 0.0805073346122375 GO:0044023 histone H4S1 kinase activity 27/1255 245/18639 0.110204081632653 1.63672818928368 0.00800028123720533 0.0805073346122375 GO:0044024 histone H2AS1 kinase activity 27/1255 245/18639 0.110204081632653 1.63672818928368 0.00800028123720533 0.0805073346122375 GO:0044025 histone H2BS14 kinase activity 27/1255 245/18639 0.110204081632653 1.63672818928368 0.00800028123720533 0.0805073346122375 GO:0072354 histone H3T3 kinase activity 27/1255 245/18639 0.110204081632653 1.63672818928368 0.00800028123720533 0.0805073346122375 GO:0072371 histone H2AS121 kinase activity 27/1255 245/18639 0.110204081632653 1.63672818928368 0.00800028123720533 0.0805073346122375 GO:0072518 Rho-dependent protein serine/threonine kinase activity 27/1255 245/18639 0.110204081632653 1.63672818928368 0.00800028123720533 0.0805073346122375 GO:0140823 histone H2BS36 kinase activity 27/1255 245/18639 0.110204081632653 1.63672818928368 0.00800028123720533 0.0805073346122375 GO:0140855 histone H3S57 kinase activity 27/1255 245/18639 0.110204081632653 1.63672818928368 0.00800028123720533 0.0805073346122375 GO:0140995 histone H2A kinase activity 27/1255 245/18639 0.110204081632653 1.63672818928368 0.00800028123720533 0.0805073346122375 GO:0140997 histone H4 kinase activity 27/1255 245/18639 0.110204081632653 1.63672818928368 0.00800028123720533 0.0805073346122375 GO:0140998 histone H2B kinase activity 27/1255 245/18639 0.110204081632653 1.63672818928368 0.00800028123720533 0.0805073346122375 GO:1990244 histone H2AT120 kinase activity 27/1255 245/18639 0.110204081632653 1.63672818928368 0.00800028123720533 0.0805073346122375 GO:0034212 protein N-acetyltransferase activity 9/1255 53/18639 0.169811320754717 2.52200255581448 0.00833536636389241 0.0825854603115272 GO:0004677 DNA-dependent protein kinase activity 27/1255 246/18639 0.109756097560976 1.63007482266058 0.00842859666563483 0.0825854603115272 GO:0140857 histone H3T45 kinase activity 27/1255 246/18639 0.109756097560976 1.63007482266058 0.00842859666563483 0.0825854603115272 GO:0035402 histone H3T11 kinase activity 27/1255 247/18639 0.109311740890688 1.62347532945143 0.00887555535172892 0.085403359807286 GO:0035403 histone H3T6 kinase activity 27/1255 247/18639 0.109311740890688 1.62347532945143 0.00887555535172892 0.085403359807286 GO:0051011 microtubule minus-end binding 4/1255 13/18639 0.307692307692308 4.56978240882623 0.00894556230747759 0.085403359807286 GO:0051213 dioxygenase activity 13/1255 93/18639 0.139784946236559 2.07605706207428 0.00930834398062579 0.0876867894592563 GO:0004679 AMP-activated protein kinase activity 27/1255 248/18639 0.108870967741935 1.6169290579617 0.00934174390837198 0.0876867894592563 GO:0140463 chromatin-protein adaptor activity 9/1255 54/18639 0.166666666666667 2.47529880478088 0.00942038337667863 0.0876880685979169 GO:0046966 nuclear thyroid hormone receptor binding 6/1255 28/18639 0.214285714285714 3.18252703471827 0.00962179525633798 0.0878029700967542 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 6/1255 28/18639 0.214285714285714 3.18252703471827 0.00962179525633798 0.0878029700967542 GO:0035091 phosphatidylinositol binding 30/1255 284/18639 0.105633802816901 1.56885135514281 0.00966854549856827 0.0878029700967542 GO:0002020 protease binding 17/1255 136/18639 0.125 1.85647410358566 0.0099242451345031 0.0893982404454836 GO:0042562 hormone binding 13/1255 94/18639 0.138297872340426 2.05397134864796 0.0101562238148374 0.0907560160093866 GO:0001221 transcription coregulator binding 15/1255 115/18639 0.130434782608696 1.93719036895895 0.0102565639668004 0.090925253578699 GO:0016922 nuclear receptor binding 17/1255 137/18639 0.124087591240876 1.84292319772007 0.0106418872510435 0.0935983311765003 GO:0010314 phosphatidylinositol-5-phosphate binding 5/1255 21/18639 0.238095238095238 3.53614114968697 0.0112738029045791 0.0976824564051834 GO:0003725 double-stranded RNA binding 11/1255 75/18639 0.146666666666667 2.17826294820717 0.0113653259680244 0.0976824564051834 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 6/1255 29/18639 0.206896551724138 3.07278472317626 0.0114560445739293 0.0976824564051834 GO:0097472 cyclin-dependent protein kinase activity 6/1255 29/18639 0.206896551724138 3.07278472317626 0.0114560445739293 0.0976824564051834 GO:0005543 phospholipid binding 47/1255 497/18639 0.0945674044265594 1.40449549888975 0.0116393315154842 0.09849343411209 GO:0001965 G-protein alpha-subunit binding 6/1255 30/18639 0.2 2.97035856573705 0.0135236777229494 0.112495627466671 GO:0098918 structural constituent of synapse 6/1255 30/18639 0.2 2.97035856573705 0.0135236777229494 0.112495627466671 GO:0050840 extracellular matrix binding 10/1255 67/18639 0.149253731343284 2.2166854968187 0.013713147642997 0.112495627466671 GO:0003724 RNA helicase activity 11/1255 77/18639 0.142857142857143 2.12168468981218 0.0137283905427306 0.112495627466671 GO:0050321 tau-protein kinase activity 5/1255 22/18639 0.227272727272727 3.37540746106483 0.0137975836731728 0.112495627466671 GO:0061980 regulatory RNA binding 9/1255 58/18639 0.155172413793103 2.3045885423822 0.0148506466066447 0.120204146808856 GO:0042809 nuclear vitamin D receptor binding 4/1255 15/18639 0.266666666666667 3.9604780876494 0.0153331426605868 0.12321669317896 GO:0003727 single-stranded RNA binding 12/1255 89/18639 0.134831460674157 2.00248892072161 0.0159691965029813 0.12741137495593 GO:0008186 ATP-dependent activity, acting on RNA 11/1255 79/18639 0.139240506329114 2.06797115336124 0.0164450531189457 0.130252308559376 GO:0008080 N-acetyltransferase activity 10/1255 69/18639 0.144927536231884 2.15243374328772 0.016668862060112 0.130252308559376 GO:0017134 fibroblast growth factor binding 5/1255 23/18639 0.217391304347826 3.22865061493158 0.0166750941127938 0.130252308559376 GO:0001098 basal transcription machinery binding 9/1255 60/18639 0.15 2.22776892430279 0.0182991039503069 0.140870668989157 GO:0001099 basal RNA polymerase II transcription machinery binding 9/1255 60/18639 0.15 2.22776892430279 0.0182991039503069 0.140870668989157 GO:0070717 poly-purine tract binding 6/1255 32/18639 0.1875 2.78471115537849 0.0184128179699346 0.140870668989157 GO:0005159 insulin-like growth factor receptor binding 4/1255 16/18639 0.25 3.71294820717131 0.0193760193391717 0.146236578390911 GO:0070411 I-SMAD binding 4/1255 16/18639 0.25 3.71294820717131 0.0193760193391717 0.146236578390911 GO:0001091 RNA polymerase II general transcription initiation factor binding 5/1255 24/18639 0.208333333333333 3.0941235059761 0.019924504537252 0.147388553431195 GO:0050431 transforming growth factor beta binding 5/1255 24/18639 0.208333333333333 3.0941235059761 0.019924504537252 0.147388553431195 GO:0070840 dynein complex binding 5/1255 24/18639 0.208333333333333 3.0941235059761 0.019924504537252 0.147388553431195 GO:0035198 miRNA binding 7/1255 42/18639 0.166666666666667 2.47529880478088 0.0209370333407493 0.153859646326427 GO:0017124 SH3 domain binding 14/1255 115/18639 0.121739130434783 1.80804434436168 0.0223898272391513 0.162638504664506 GO:0019787 ubiquitin-like protein transferase activity 44/1255 479/18639 0.0918580375782881 1.36425654376232 0.0224228556117582 0.162638504664506 GO:0019783 ubiquitin-like protein peptidase activity 15/1255 127/18639 0.118110236220472 1.75414875929353 0.0237249770695657 0.170972899269064 GO:0005092 GDP-dissociation inhibitor activity 4/1255 17/18639 0.235294117647059 3.49453948910241 0.0240176149614833 0.171972281487031 GO:0030332 cyclin binding 6/1255 34/18639 0.176470588235294 2.62090461682681 0.0243888226718865 0.173258425747208 GO:1901981 phosphatidylinositol phosphate binding 20/1255 185/18639 0.108108108108108 1.60559922472273 0.0245074586106167 0.173258425747208 GO:0008276 protein methyltransferase activity 12/1255 95/18639 0.126315789473684 1.87601593625498 0.0255112834789377 0.175989369917257 GO:0016755 aminoacyltransferase activity 45/1255 496/18639 0.0907258064516129 1.34744088163475 0.0255162601843965 0.175989369917257 GO:0016303 1-phosphatidylinositol-3-kinase activity 3/1255 10/18639 0.3 4.45553784860558 0.025552190157643 0.175989369917257 GO:0000149 SNARE binding 13/1255 106/18639 0.122641509433962 1.82144629031046 0.0256815284659918 0.175989369917257 GO:0008013 beta-catenin binding 13/1255 106/18639 0.122641509433962 1.82144629031046 0.0256815284659918 0.175989369917257 GO:0001046 core promoter sequence-specific DNA binding 7/1255 44/18639 0.159090909090909 2.36278522274538 0.026489600076068 0.180420020030293 GO:0008143 poly(A) binding 5/1255 26/18639 0.192307692307692 2.8561140055164 0.0276014657833917 0.185727935421979 GO:0052742 phosphatidylinositol kinase activity 5/1255 26/18639 0.192307692307692 2.8561140055164 0.0276014657833917 0.185727935421979 GO:0140566 histone reader activity 6/1255 35/18639 0.171428571428571 2.54602162777462 0.027811632348707 0.1860215169671 GO:0004842 ubiquitin-protein transferase activity 41/1255 449/18639 0.0913140311804009 1.35617707344342 0.0291046801491337 0.193493512033978 GO:1990381 ubiquitin-specific protease binding 4/1255 18/18639 0.222222222222222 3.3003984063745 0.0292752045960093 0.193493512033978 GO:0032182 ubiquitin-like protein binding 14/1255 120/18639 0.116666666666667 1.73270916334661 0.0309687145868814 0.203482671726745 GO:0019902 phosphatase binding 20/1255 190/18639 0.105263157894737 1.56334661354582 0.0314281105946622 0.205293564527706 GO:0004143 ATP-dependent diacylglycerol kinase activity 3/1255 11/18639 0.272727272727273 4.0504889532778 0.0334088149148857 0.214469231378893 GO:0008172 S-methyltransferase activity 3/1255 11/18639 0.272727272727273 4.0504889532778 0.0334088149148857 0.214469231378893 GO:0097493 structural molecule activity conferring elasticity 3/1255 11/18639 0.272727272727273 4.0504889532778 0.0334088149148857 0.214469231378893 GO:0005201 extracellular matrix structural constituent 18/1255 168/18639 0.107142857142857 1.59126351735913 0.0341854497780915 0.218200842297876 GO:0042800 histone H3K4 methyltransferase activity 4/1255 19/18639 0.210526315789474 3.12669322709163 0.0351604523454351 0.22188827836074 GO:1990380 K48-linked deubiquitinase activity 4/1255 19/18639 0.210526315789474 3.12669322709163 0.0351604523454351 0.22188827836074 GO:0043130 ubiquitin binding 12/1255 100/18639 0.12 1.78221513944223 0.036200356272617 0.227167404250074 GO:1990841 promoter-specific chromatin binding 9/1255 68/18639 0.132352941176471 1.96567846262011 0.0379630824556927 0.236898117893904 GO:0019838 growth factor binding 15/1255 136/18639 0.110294117647059 1.63806538551676 0.0403716555509107 0.249466152972554 GO:0140693 molecular condensate scaffold activity 7/1255 48/18639 0.145833333333333 2.16588645418327 0.0404237902310047 0.249466152972554 GO:0031418 L-ascorbic acid binding 4/1255 20/18639 0.2 2.97035856573705 0.0416796403658291 0.250385084284343 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 5/1255 29/18639 0.172413793103448 2.56065393598022 0.042238966896542 0.250385084284343 GO:0099604 ligand-gated calcium channel activity 5/1255 29/18639 0.172413793103448 2.56065393598022 0.042238966896542 0.250385084284343 GO:0000340 RNA 7-methylguanosine cap binding 3/1255 12/18639 0.25 3.71294820717131 0.042365963231639 0.250385084284343 GO:0005165 neurotrophin receptor binding 3/1255 12/18639 0.25 3.71294820717131 0.042365963231639 0.250385084284343 GO:0008504 monoamine transmembrane transporter activity 3/1255 12/18639 0.25 3.71294820717131 0.042365963231639 0.250385084284343 GO:0031543 peptidyl-proline dioxygenase activity 3/1255 12/18639 0.25 3.71294820717131 0.042365963231639 0.250385084284343 GO:1990247 N6-methyladenosine-containing RNA reader activity 3/1255 12/18639 0.25 3.71294820717131 0.042365963231639 0.250385084284343 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 5/1255 30/18639 0.166666666666667 2.47529880478088 0.0479820247312604 0.277699075776258 GO:0008187 poly-pyrimidine tract binding 5/1255 30/18639 0.166666666666667 2.47529880478088 0.0479820247312604 0.277699075776258 GO:0031624 ubiquitin conjugating enzyme binding 5/1255 30/18639 0.166666666666667 2.47529880478088 0.0479820247312604 0.277699075776258 GO:0032452 histone demethylase activity 5/1255 30/18639 0.166666666666667 2.47529880478088 0.0479820247312604 0.277699075776258 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 4/1255 21/18639 0.19047619047619 2.82891291974957 0.0488339550625938 0.281172823736687 GO:0005518 collagen binding 9/1255 72/18639 0.125 1.85647410358566 0.0518105014332344 0.295565440805188 GO:0046974 histone H3K9 methyltransferase activity 3/1255 13/18639 0.230769230769231 3.42733680661967 0.0523920835088874 0.295565440805188 GO:0097157 pre-mRNA intronic binding 3/1255 13/18639 0.230769230769231 3.42733680661967 0.0523920835088874 0.295565440805188 GO:0140666 annealing activity 3/1255 13/18639 0.230769230769231 3.42733680661967 0.0523920835088874 0.295565440805188 GO:0070273 phosphatidylinositol-4-phosphate binding 5/1255 31/18639 0.161290322580645 2.39545045623956 0.0541635089357322 0.302503197406064 GO:0140457 protein demethylase activity 5/1255 31/18639 0.161290322580645 2.39545045623956 0.0541635089357322 0.302503197406064 GO:0051117 ATPase binding 10/1255 84/18639 0.119047619047619 1.76807057484348 0.0552615799216105 0.307100421753427 GO:0001217 DNA-binding transcription repressor activity 26/1255 278/18639 0.0935251798561151 1.38901659548855 0.0560814433775825 0.310021243969619 GO:0070034 telomerase RNA binding 4/1255 22/18639 0.181818181818182 2.70032596885187 0.056619815371354 0.310021243969619 GO:0140517 protein-RNA adaptor activity 4/1255 22/18639 0.181818181818182 2.70032596885187 0.056619815371354 0.310021243969619 GO:0016407 acetyltransferase activity 11/1255 96/18639 0.114583333333333 1.70176792828685 0.0576825002221957 0.3142992816985 GO:0003684 damaged DNA binding 9/1255 74/18639 0.121621621621622 1.80629912781307 0.0598319227652539 0.324428435576644 GO:0043175 RNA polymerase core enzyme binding 6/1255 42/18639 0.142857142857143 2.12168468981218 0.0606051429188605 0.327033548987281 GO:0005085 guanyl-nucleotide exchange factor activity 22/1255 230/18639 0.0956521739130435 1.42060627056989 0.0610908008571392 0.328069348833772 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 25/1255 268/18639 0.0932835820895522 1.38542843551168 0.0615387131945515 0.328893505446479 GO:0005161 platelet-derived growth factor receptor binding 3/1255 14/18639 0.214285714285714 3.18252703471827 0.063444666789638 0.331874054972881 GO:0005313 L-glutamate transmembrane transporter activity 3/1255 14/18639 0.214285714285714 3.18252703471827 0.063444666789638 0.331874054972881 GO:0005545 1-phosphatidylinositol binding 3/1255 14/18639 0.214285714285714 3.18252703471827 0.063444666789638 0.331874054972881 GO:0030983 mismatched DNA binding 3/1255 14/18639 0.214285714285714 3.18252703471827 0.063444666789638 0.331874054972881 GO:0140296 general transcription initiation factor binding 7/1255 53/18639 0.132075471698113 1.96155754341126 0.063581958607159 0.331874054972881 GO:0099186 structural constituent of postsynapse 4/1255 23/18639 0.173913043478261 2.58292049194526 0.0650292303731562 0.337849536403793 GO:0030296 protein tyrosine kinase activator activity 5/1255 33/18639 0.151515151515152 2.25027164070989 0.0678419955443603 0.3508310602919 GO:0004197 cysteine-type endopeptidase activity 10/1255 88/18639 0.113636363636364 1.68770373053242 0.0713164246815833 0.367098831195062 GO:0030020 extracellular matrix structural constituent conferring tensile strength 6/1255 44/18639 0.136363636363636 2.0252444766389 0.0729399167369294 0.373733426583257 GO:0140033 acetylation-dependent protein binding 4/1255 24/18639 0.166666666666667 2.47529880478088 0.074050175540337 0.377689708121262 GO:0140776 protein-containing complex destabilizing activity 3/1255 15/18639 0.2 2.97035856573705 0.0754725478219007 0.383194708713923 GO:0003707 nuclear steroid receptor activity 4/1255 25/18639 0.16 2.37628685258964 0.0836669786949621 0.422877896842863 GO:0101005 deubiquitinase activity 12/1255 115/18639 0.104347826086957 1.54975229516716 0.0862299875305538 0.431278580405592 GO:0030276 clathrin binding 6/1255 46/18639 0.130434782608696 1.93719036895895 0.086601839938141 0.431278580405592 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 3/1255 16/18639 0.1875 2.78471115537849 0.0884179005486845 0.431278580405592 GO:0005024 transforming growth factor beta receptor activity 3/1255 16/18639 0.1875 2.78471115537849 0.0884179005486845 0.431278580405592 GO:0005521 lamin binding 3/1255 16/18639 0.1875 2.78471115537849 0.0884179005486845 0.431278580405592 GO:0015378 sodium:chloride symporter activity 3/1255 16/18639 0.1875 2.78471115537849 0.0884179005486845 0.431278580405592 GO:0016722 oxidoreductase activity, acting on metal ions 3/1255 16/18639 0.1875 2.78471115537849 0.0884179005486845 0.431278580405592 GO:0034450 ubiquitin-ubiquitin ligase activity 3/1255 16/18639 0.1875 2.78471115537849 0.0884179005486845 0.431278580405592 GO:0002039 p53 binding 8/1255 69/18639 0.115942028985507 1.72194699463017 0.0913514668628806 0.437179766984562 GO:0000993 RNA polymerase II complex binding 5/1255 36/18639 0.138888888888889 2.06274900398406 0.091595833541605 0.437179766984562 GO:0005484 SNAP receptor activity 5/1255 36/18639 0.138888888888889 2.06274900398406 0.091595833541605 0.437179766984562 GO:0044390 ubiquitin-like protein conjugating enzyme binding 5/1255 36/18639 0.138888888888889 2.06274900398406 0.091595833541605 0.437179766984562 GO:0045505 dynein intermediate chain binding 5/1255 36/18639 0.138888888888889 2.06274900398406 0.091595833541605 0.437179766984562 GO:0061659 ubiquitin-like protein ligase activity 32/1255 372/18639 0.0860215053763441 1.2775735766611 0.0919760476646124 0.437179766984562 GO:0005160 transforming growth factor beta receptor binding 4/1255 26/18639 0.153846153846154 2.28489120441312 0.0938607083152476 0.442373042987897 GO:0050750 low-density lipoprotein particle receptor binding 4/1255 26/18639 0.153846153846154 2.28489120441312 0.0938607083152476 0.442373042987897 GO:0035591 signaling adaptor activity 13/1255 129/18639 0.10077519379845 1.49669230056518 0.0943031507173491 0.442590837610416 GO:0097110 scaffold protein binding 8/1255 70/18639 0.114285714285714 1.69734775184974 0.0973932270108738 0.454416066320377 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 16/1255 167/18639 0.0958083832335329 1.42292625903571 0.0976363974188815 0.454416066320377 GO:0004879 nuclear receptor activity 7/1255 59/18639 0.11864406779661 1.76207711526774 0.100165721733241 0.461523533743332 GO:0036002 pre-mRNA binding 7/1255 59/18639 0.11864406779661 1.76207711526774 0.100165721733241 0.461523533743332 GO:0016410 N-acyltransferase activity 10/1255 94/18639 0.106382978723404 1.57997796049843 0.100403060608442 0.461523533743332 GO:0004029 aldehyde dehydrogenase (NAD+) activity 3/1255 17/18639 0.176470588235294 2.62090461682681 0.102217961745942 0.466030462327417 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 3/1255 17/18639 0.176470588235294 2.62090461682681 0.102217961745942 0.466030462327417 GO:0003779 actin binding 37/1255 443/18639 0.0835214446952596 1.24044319336649 0.10273816195659 0.46649807685167 GO:0008266 poly(U) RNA binding 4/1255 27/18639 0.148148148148148 2.20026560424967 0.10460955817323 0.470936277597355 GO:0035255 ionotropic glutamate receptor binding 4/1255 27/18639 0.148148148148148 2.20026560424967 0.10460955817323 0.470936277597355 GO:0005516 calmodulin binding 19/1255 207/18639 0.0917874396135266 1.36320803741556 0.104980423564674 0.470936277597355 GO:0098531 ligand-modulated transcription factor activity 7/1255 60/18639 0.116666666666667 1.73270916334661 0.107186683095346 0.478910100070004 GO:0005501 retinoid binding 5/1255 38/18639 0.131578947368421 1.95418326693227 0.109504689531269 0.483553210107227 GO:0019840 isoprenoid binding 5/1255 38/18639 0.131578947368421 1.95418326693227 0.109504689531269 0.483553210107227 GO:0001222 transcription corepressor binding 6/1255 49/18639 0.122448979591837 1.81858687698187 0.109524585637537 0.483553210107227 GO:0004843 cysteine-type deubiquitinase activity 11/1255 108/18639 0.101851851851852 1.51268260292165 0.110720677384497 0.485029275901532 GO:0061630 ubiquitin protein ligase activity 30/1255 353/18639 0.084985835694051 1.26219202510073 0.111839673357717 0.485029275901532 GO:0015026 coreceptor activity 7/1255 61/18639 0.114754098360656 1.70430409509503 0.114463733131924 0.485029275901532 GO:0051959 dynein light intermediate chain binding 4/1255 28/18639 0.142857142857143 2.12168468981218 0.115889223452753 0.485029275901532 GO:0141052 histone H3 demethylase activity 4/1255 28/18639 0.142857142857143 2.12168468981218 0.115889223452753 0.485029275901532 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 3/1255 18/18639 0.166666666666667 2.47529880478088 0.116806513175928 0.485029275901532 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 3/1255 18/18639 0.166666666666667 2.47529880478088 0.116806513175928 0.485029275901532 GO:0008409 5'-3' exonuclease activity 3/1255 18/18639 0.166666666666667 2.47529880478088 0.116806513175928 0.485029275901532 GO:0015172 acidic amino acid transmembrane transporter activity 3/1255 18/18639 0.166666666666667 2.47529880478088 0.116806513175928 0.485029275901532 GO:0015373 monoatomic anion:sodium symporter activity 3/1255 18/18639 0.166666666666667 2.47529880478088 0.116806513175928 0.485029275901532 GO:0017075 syntaxin-1 binding 3/1255 18/18639 0.166666666666667 2.47529880478088 0.116806513175928 0.485029275901532 GO:0031690 adrenergic receptor binding 3/1255 18/18639 0.166666666666667 2.47529880478088 0.116806513175928 0.485029275901532 GO:0035615 clathrin adaptor activity 3/1255 18/18639 0.166666666666667 2.47529880478088 0.116806513175928 0.485029275901532 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 3/1255 18/18639 0.166666666666667 2.47529880478088 0.116806513175928 0.485029275901532 GO:0070064 proline-rich region binding 3/1255 18/18639 0.166666666666667 2.47529880478088 0.116806513175928 0.485029275901532 GO:0098641 cadherin binding involved in cell-cell adhesion 3/1255 18/18639 0.166666666666667 2.47529880478088 0.116806513175928 0.485029275901532 GO:0051087 protein-folding chaperone binding 13/1255 134/18639 0.0970149253731343 1.44084557293215 0.117412972058777 0.485741814035754 GO:0000217 DNA secondary structure binding 5/1255 39/18639 0.128205128205128 1.9040760036776 0.119049348188664 0.490694176851431 GO:0030544 Hsp70 protein binding 6/1255 51/18639 0.117647058823529 1.74726974455121 0.126360440355252 0.518585587085277 GO:1902936 phosphatidylinositol bisphosphate binding 11/1255 111/18639 0.0990990990990991 1.47179928932917 0.127305696767505 0.518585587085277 GO:0043236 laminin binding 4/1255 29/18639 0.137931034482759 2.04852314878417 0.127673264501747 0.518585587085277 GO:0106222 lncRNA binding 4/1255 29/18639 0.137931034482759 2.04852314878417 0.127673264501747 0.518585587085277 GO:0032451 demethylase activity 5/1255 40/18639 0.125 1.85647410358566 0.128970075194081 0.520070664230285 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 5/1255 40/18639 0.125 1.85647410358566 0.128970075194081 0.520070664230285 GO:0120227 acyl-CoA binding 3/1255 19/18639 0.157894736842105 2.34501992031872 0.132115149581646 0.530836770081649 GO:0030159 signaling receptor complex adaptor activity 6/1255 52/18639 0.115384615384615 1.71366840330984 0.135222090117814 0.535410443417986 GO:0017022 myosin binding 8/1255 76/18639 0.105263157894737 1.56334661354582 0.138183950303727 0.535410443417986 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 5/1255 41/18639 0.121951219512195 1.81119424740064 0.139252270342983 0.535410443417986 GO:0042169 SH2 domain binding 5/1255 41/18639 0.121951219512195 1.81119424740064 0.139252270342983 0.535410443417986 GO:0035925 mRNA 3'-UTR AU-rich region binding 4/1255 30/18639 0.133333333333333 1.9802390438247 0.139933455235667 0.535410443417986 GO:0048019 receptor antagonist activity 4/1255 30/18639 0.133333333333333 1.9802390438247 0.139933455235667 0.535410443417986 GO:0043021 ribonucleoprotein complex binding 16/1255 177/18639 0.0903954802259887 1.3425349449659 0.140942138497831 0.535410443417986 GO:0005131 growth hormone receptor binding 2/1255 10/18639 0.2 2.97035856573705 0.1423606998166 0.535410443417986 GO:0005522 profilin binding 2/1255 10/18639 0.2 2.97035856573705 0.1423606998166 0.535410443417986 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 2/1255 10/18639 0.2 2.97035856573705 0.1423606998166 0.535410443417986 GO:0015643 toxic substance binding 2/1255 10/18639 0.2 2.97035856573705 0.1423606998166 0.535410443417986 GO:0016868 intramolecular phosphotransferase activity 2/1255 10/18639 0.2 2.97035856573705 0.1423606998166 0.535410443417986 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 2/1255 10/18639 0.2 2.97035856573705 0.1423606998166 0.535410443417986 GO:0035374 chondroitin sulfate binding 2/1255 10/18639 0.2 2.97035856573705 0.1423606998166 0.535410443417986 GO:0050815 phosphoserine residue binding 2/1255 10/18639 0.2 2.97035856573705 0.1423606998166 0.535410443417986 GO:0051880 G-quadruplex DNA binding 2/1255 10/18639 0.2 2.97035856573705 0.1423606998166 0.535410443417986 GO:0140999 histone H3K4 trimethyltransferase activity 2/1255 10/18639 0.2 2.97035856573705 0.1423606998166 0.535410443417986 GO:1990757 ubiquitin ligase activator activity 2/1255 10/18639 0.2 2.97035856573705 0.1423606998166 0.535410443417986 GO:1990763 arrestin family protein binding 2/1255 10/18639 0.2 2.97035856573705 0.1423606998166 0.535410443417986 GO:0017046 peptide hormone binding 6/1255 53/18639 0.113207547169811 1.68133503720965 0.144367638821302 0.541136417997967 GO:0000339 RNA cap binding 3/1255 20/18639 0.15 2.22776892430279 0.148074357090319 0.547678996257903 GO:0016505 peptidase activator activity involved in apoptotic process 3/1255 20/18639 0.15 2.22776892430279 0.148074357090319 0.547678996257903 GO:0052745 inositol phosphate phosphatase activity 3/1255 20/18639 0.15 2.22776892430279 0.148074357090319 0.547678996257903 GO:0140939 histone H4 methyltransferase activity 3/1255 20/18639 0.15 2.22776892430279 0.148074357090319 0.547678996257903 GO:0019894 kinesin binding 5/1255 42/18639 0.119047619047619 1.76807057484348 0.149880260535432 0.55071135203315 GO:0031492 nucleosomal DNA binding 5/1255 42/18639 0.119047619047619 1.76807057484348 0.149880260535432 0.55071135203315 GO:0070325 lipoprotein particle receptor binding 4/1255 31/18639 0.129032258064516 1.91636036499165 0.152640113946769 0.559013138618168 GO:0008200 ion channel inhibitor activity 5/1255 43/18639 0.116279069767442 1.72695265449829 0.160837428678672 0.572495940556138 GO:0048156 tau protein binding 5/1255 43/18639 0.116279069767442 1.72695265449829 0.160837428678672 0.572495940556138 GO:0051010 microtubule plus-end binding 3/1255 21/18639 0.142857142857143 2.12168468981218 0.16461442409494 0.572495940556138 GO:0140312 cargo adaptor activity 3/1255 21/18639 0.142857142857143 2.12168468981218 0.16461442409494 0.572495940556138 GO:1901681 sulfur compound binding 23/1255 275/18639 0.0836363636363636 1.24214994567186 0.166146327116712 0.572495940556138 GO:0000099 sulfur amino acid transmembrane transporter activity 2/1255 11/18639 0.181818181818182 2.70032596885187 0.166572229794758 0.572495940556138 GO:0005114 type II transforming growth factor beta receptor binding 2/1255 11/18639 0.181818181818182 2.70032596885187 0.166572229794758 0.572495940556138 GO:0008432 JUN kinase binding 2/1255 11/18639 0.181818181818182 2.70032596885187 0.166572229794758 0.572495940556138 GO:0016176 superoxide-generating NADPH oxidase activator activity 2/1255 11/18639 0.181818181818182 2.70032596885187 0.166572229794758 0.572495940556138 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 2/1255 11/18639 0.181818181818182 2.70032596885187 0.166572229794758 0.572495940556138 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 2/1255 11/18639 0.181818181818182 2.70032596885187 0.166572229794758 0.572495940556138 GO:0034056 estrogen response element binding 2/1255 11/18639 0.181818181818182 2.70032596885187 0.166572229794758 0.572495940556138 GO:0034511 U3 snoRNA binding 2/1255 11/18639 0.181818181818182 2.70032596885187 0.166572229794758 0.572495940556138 GO:0035252 UDP-xylosyltransferase activity 2/1255 11/18639 0.181818181818182 2.70032596885187 0.166572229794758 0.572495940556138 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 2/1255 11/18639 0.181818181818182 2.70032596885187 0.166572229794758 0.572495940556138 GO:0042285 xylosyltransferase activity 2/1255 11/18639 0.181818181818182 2.70032596885187 0.166572229794758 0.572495940556138 GO:0048185 activin binding 2/1255 11/18639 0.181818181818182 2.70032596885187 0.166572229794758 0.572495940556138 GO:0048407 platelet-derived growth factor binding 2/1255 11/18639 0.181818181818182 2.70032596885187 0.166572229794758 0.572495940556138 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 2/1255 11/18639 0.181818181818182 2.70032596885187 0.166572229794758 0.572495940556138 GO:0180030 inositol phosphate kinase activity 2/1255 11/18639 0.181818181818182 2.70032596885187 0.166572229794758 0.572495940556138 GO:0051015 actin filament binding 18/1255 209/18639 0.0861244019138756 1.2791017747193 0.169289409436414 0.58004990901986 GO:0031072 heat shock protein binding 12/1255 131/18639 0.0916030534351145 1.36046957209331 0.172008988105379 0.582020366458597 GO:0016248 channel inhibitor activity 5/1255 44/18639 0.113636363636364 1.68770373053242 0.172106340466075 0.582020366458597 GO:0043014 alpha-tubulin binding 5/1255 44/18639 0.113636363636364 1.68770373053242 0.172106340466075 0.582020366458597 GO:0003777 microtubule motor activity 7/1255 68/18639 0.102941176470588 1.52886102648231 0.172131382888412 0.582020366458597 GO:0019903 protein phosphatase binding 13/1255 144/18639 0.0902777777777778 1.34078685258964 0.172469777348071 0.582020366458597 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 4/1255 33/18639 0.121212121212121 1.80021731256791 0.179268679640566 0.603141913128048 GO:0015377 chloride:monoatomic cation symporter activity 3/1255 22/18639 0.136363636363636 2.0252444766389 0.181666204419717 0.607548354301868 GO:0016881 acid-amino acid ligase activity 3/1255 22/18639 0.136363636363636 2.0252444766389 0.181666204419717 0.607548354301868 GO:0004601 peroxidase activity 6/1255 57/18639 0.105263157894737 1.56334661354582 0.183582384575067 0.610589659921045 GO:0141110 transporter inhibitor activity 5/1255 45/18639 0.111111111111111 1.65019920318725 0.183668868158882 0.610589659921045 GO:0005049 nuclear export signal receptor activity 2/1255 12/18639 0.166666666666667 2.47529880478088 0.191413483107382 0.621537385555075 GO:0005078 MAP-kinase scaffold activity 2/1255 12/18639 0.166666666666667 2.47529880478088 0.191413483107382 0.621537385555075 GO:0005095 GTPase inhibitor activity 2/1255 12/18639 0.166666666666667 2.47529880478088 0.191413483107382 0.621537385555075 GO:0008179 adenylate cyclase binding 2/1255 12/18639 0.166666666666667 2.47529880478088 0.191413483107382 0.621537385555075 GO:0035197 siRNA binding 2/1255 12/18639 0.166666666666667 2.47529880478088 0.191413483107382 0.621537385555075 GO:0035259 nuclear glucocorticoid receptor binding 2/1255 12/18639 0.166666666666667 2.47529880478088 0.191413483107382 0.621537385555075 GO:0070679 inositol 1,4,5 trisphosphate binding 2/1255 12/18639 0.166666666666667 2.47529880478088 0.191413483107382 0.621537385555075 GO:0097371 MDM2/MDM4 family protein binding 2/1255 12/18639 0.166666666666667 2.47529880478088 0.191413483107382 0.621537385555075 GO:0052866 phosphatidylinositol phosphate phosphatase activity 4/1255 34/18639 0.117647058823529 1.74726974455121 0.193126647339083 0.624154382924093 GO:0008234 cysteine-type peptidase activity 16/1255 187/18639 0.0855614973262032 1.27074163240088 0.193336988801912 0.624154382924093 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 6/1255 58/18639 0.103448275862069 1.53639236158813 0.193987511255963 0.624449712025678 GO:0030165 PDZ domain binding 8/1255 83/18639 0.0963855421686747 1.43149810396966 0.194794723195819 0.625246281062441 GO:0003887 DNA-directed DNA polymerase activity 3/1255 23/18639 0.130434782608696 1.93719036895895 0.199161750526701 0.631999077665697 GO:0005158 insulin receptor binding 3/1255 23/18639 0.130434782608696 1.93719036895895 0.199161750526701 0.631999077665697 GO:0031681 G-protein beta-subunit binding 3/1255 23/18639 0.130434782608696 1.93719036895895 0.199161750526701 0.631999077665697 GO:0070577 lysine-acetylated histone binding 3/1255 23/18639 0.130434782608696 1.93719036895895 0.199161750526701 0.631999077665697 GO:0016741 transferase activity, transferring one-carbon groups 18/1255 215/18639 0.0837209302325581 1.24340591123877 0.200251625164965 0.633657408808119 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 6/1255 59/18639 0.101694915254237 1.51035181308664 0.204608845918913 0.645616047715891 GO:0034061 DNA polymerase activity 4/1255 35/18639 0.114285714285714 1.69734775184974 0.207303723964275 0.650444549629482 GO:0043015 gamma-tubulin binding 4/1255 35/18639 0.114285714285714 1.69734775184974 0.207303723964275 0.650444549629482 GO:0008168 methyltransferase activity 17/1255 204/18639 0.0833333333333333 1.23764940239044 0.213893247943072 0.667845476831187 GO:0005172 vascular endothelial growth factor receptor binding 2/1255 13/18639 0.153846153846154 2.28489120441312 0.216690101216199 0.667845476831187 GO:0070123 transforming growth factor beta receptor activity, type III 2/1255 13/18639 0.153846153846154 2.28489120441312 0.216690101216199 0.667845476831187 GO:0140852 histone ubiquitin ligase activity 2/1255 13/18639 0.153846153846154 2.28489120441312 0.216690101216199 0.667845476831187 GO:0035035 histone acetyltransferase binding 3/1255 24/18639 0.125 1.85647410358566 0.21703483266761 0.667845476831187 GO:0048027 mRNA 5'-UTR binding 3/1255 24/18639 0.125 1.85647410358566 0.21703483266761 0.667845476831187 GO:0140612 DNA damage sensor activity 3/1255 24/18639 0.125 1.85647410358566 0.21703483266761 0.667845476831187 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 5/1255 48/18639 0.104166666666667 1.54706175298805 0.219928957504063 0.674891883329776 GO:0016209 antioxidant activity 8/1255 86/18639 0.0930232558139535 1.38156212359863 0.221598376781073 0.678151744834132 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 6/1255 61/18639 0.0983606557377049 1.46083208151003 0.226448417682013 0.691100771996745 GO:0003774 cytoskeletal motor activity 13/1255 153/18639 0.0849673202614379 1.26191703773143 0.231075766252004 0.703301446603511 GO:0035254 glutamate receptor binding 5/1255 49/18639 0.102040816326531 1.51548906415156 0.232474908852532 0.70372485958883 GO:0060590 ATPase regulator activity 5/1255 49/18639 0.102040816326531 1.51548906415156 0.232474908852532 0.70372485958883 GO:0015296 monoatomic anion:monoatomic cation symporter activity 3/1255 25/18639 0.12 1.78221513944223 0.235221358209335 0.708200153961799 GO:0019211 phosphatase activator activity 3/1255 25/18639 0.12 1.78221513944223 0.235221358209335 0.708200153961799 GO:0004705 JUN kinase activity 2/1255 14/18639 0.142857142857143 2.12168468981218 0.242231006953959 0.71203167044098 GO:0008195 phosphatidate phosphatase activity 2/1255 14/18639 0.142857142857143 2.12168468981218 0.242231006953959 0.71203167044098 GO:0008331 high voltage-gated calcium channel activity 2/1255 14/18639 0.142857142857143 2.12168468981218 0.242231006953959 0.71203167044098 GO:0032454 histone H3K9 demethylase activity 2/1255 14/18639 0.142857142857143 2.12168468981218 0.242231006953959 0.71203167044098 GO:0034236 protein kinase A catalytic subunit binding 2/1255 14/18639 0.142857142857143 2.12168468981218 0.242231006953959 0.71203167044098 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 2/1255 14/18639 0.142857142857143 2.12168468981218 0.242231006953959 0.71203167044098 GO:0042043 neurexin family protein binding 2/1255 14/18639 0.142857142857143 2.12168468981218 0.242231006953959 0.71203167044098 GO:0070742 C2H2 zinc finger domain binding 2/1255 14/18639 0.142857142857143 2.12168468981218 0.242231006953959 0.71203167044098 GO:1990825 sequence-specific mRNA binding 2/1255 14/18639 0.142857142857143 2.12168468981218 0.242231006953959 0.71203167044098 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 11/1255 128/18639 0.0859375 1.27632594621514 0.243721723520407 0.714533241922034 GO:0035401 histone H3Y41 kinase activity 10/1255 115/18639 0.0869565217391304 1.29146024597263 0.246189802667481 0.718000025011948 GO:0140801 histone H2AXY142 kinase activity 10/1255 115/18639 0.0869565217391304 1.29146024597263 0.246189802667481 0.718000025011948 GO:0098631 cell adhesion mediator activity 7/1255 76/18639 0.0921052631578947 1.36792828685259 0.250111247996038 0.72650740819968 GO:0000146 microfilament motor activity 4/1255 38/18639 0.105263157894737 1.56334661354582 0.251423311182917 0.72650740819968 GO:0005227 calcium-activated cation channel activity 3/1255 26/18639 0.115384615384615 1.71366840330984 0.253659703847695 0.72650740819968 GO:0008157 protein phosphatase 1 binding 3/1255 26/18639 0.115384615384615 1.71366840330984 0.253659703847695 0.72650740819968 GO:0030507 spectrin binding 3/1255 26/18639 0.115384615384615 1.71366840330984 0.253659703847695 0.72650740819968 GO:0070006 metalloaminopeptidase activity 3/1255 26/18639 0.115384615384615 1.71366840330984 0.253659703847695 0.72650740819968 GO:0070412 R-SMAD binding 3/1255 26/18639 0.115384615384615 1.71366840330984 0.253659703847695 0.72650740819968 GO:0019208 phosphatase regulator activity 10/1255 117/18639 0.0854700854700855 1.26938400245173 0.262964284606663 0.746206570051692 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 4/1255 39/18639 0.102564102564103 1.52326080294208 0.266551764096546 0.746206570051692 GO:0016776 phosphotransferase activity, phosphate group as acceptor 4/1255 39/18639 0.102564102564103 1.52326080294208 0.266551764096546 0.746206570051692 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 2/1255 15/18639 0.133333333333333 1.9802390438247 0.267886154512738 0.746206570051692 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 2/1255 15/18639 0.133333333333333 1.9802390438247 0.267886154512738 0.746206570051692 GO:0017081 chloride channel regulator activity 2/1255 15/18639 0.133333333333333 1.9802390438247 0.267886154512738 0.746206570051692 GO:0045504 dynein heavy chain binding 2/1255 15/18639 0.133333333333333 1.9802390438247 0.267886154512738 0.746206570051692 GO:0050780 dopamine receptor binding 2/1255 15/18639 0.133333333333333 1.9802390438247 0.267886154512738 0.746206570051692 GO:0051371 muscle alpha-actinin binding 2/1255 15/18639 0.133333333333333 1.9802390438247 0.267886154512738 0.746206570051692 GO:0061578 K63-linked deubiquitinase activity 2/1255 15/18639 0.133333333333333 1.9802390438247 0.267886154512738 0.746206570051692 GO:0120283 protein serine/threonine kinase binding 2/1255 15/18639 0.133333333333333 1.9802390438247 0.267886154512738 0.746206570051692 GO:0008201 heparin binding 14/1255 172/18639 0.0813953488372093 1.2088668581488 0.269280045018882 0.74822340867187 GO:0001671 ATPase activator activity 3/1255 27/18639 0.111111111111111 1.65019920318725 0.272290972057003 0.752844098484336 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 3/1255 27/18639 0.111111111111111 1.65019920318725 0.272290972057003 0.752844098484336 GO:0043178 alcohol binding 8/1255 92/18639 0.0869565217391304 1.29146024597263 0.278786135613469 0.768899045630233 GO:0004177 aminopeptidase activity 4/1255 40/18639 0.1 1.48517928286853 0.281838618419042 0.773498124752016 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 4/1255 40/18639 0.1 1.48517928286853 0.281838618419042 0.773498124752016 GO:0051219 phosphoprotein binding 8/1255 93/18639 0.0860215053763441 1.2775735766611 0.288692346125165 0.783352912342932 GO:0005178 integrin binding 13/1255 161/18639 0.0807453416149068 1.19921308554601 0.288914579395331 0.783352912342932 GO:0004721 phosphoprotein phosphatase activity 14/1255 175/18639 0.08 1.18814342629482 0.290637074044936 0.783352912342932 GO:0051393 alpha-actinin binding 3/1255 28/18639 0.107142857142857 1.59126351735913 0.291059181889513 0.783352912342932 GO:0048306 calcium-dependent protein binding 7/1255 80/18639 0.0875 1.29953187250996 0.292557435159522 0.783352912342932 GO:0000062 fatty-acyl-CoA binding 2/1255 16/18639 0.125 1.85647410358566 0.293524476507603 0.783352912342932 GO:0004707 MAP kinase activity 2/1255 16/18639 0.125 1.85647410358566 0.293524476507603 0.783352912342932 GO:0017070 U6 snRNA binding 2/1255 16/18639 0.125 1.85647410358566 0.293524476507603 0.783352912342932 GO:0022858 alanine transmembrane transporter activity 2/1255 16/18639 0.125 1.85647410358566 0.293524476507603 0.783352912342932 GO:0031435 mitogen-activated protein kinase kinase kinase binding 2/1255 16/18639 0.125 1.85647410358566 0.293524476507603 0.783352912342932 GO:0097027 ubiquitin-protein transferase activator activity 2/1255 16/18639 0.125 1.85647410358566 0.293524476507603 0.783352912342932 GO:0016791 phosphatase activity 21/1255 273/18639 0.0769230769230769 1.14244560220656 0.294494722691422 0.783352912342932 GO:0019209 kinase activator activity 12/1255 148/18639 0.0810810810810811 1.20419941854205 0.294546305446761 0.783352912342932 GO:0008137 NADH dehydrogenase (ubiquinone) activity 4/1255 41/18639 0.0975609756097561 1.44895539792051 0.297253358751589 0.784419138857581 GO:0051082 unfolded protein binding 10/1255 121/18639 0.0826446280991736 1.22742089493267 0.297535538598055 0.784419138857581 GO:0015485 cholesterol binding 5/1255 54/18639 0.0925925925925926 1.37516600265604 0.297756235340747 0.784419138857581 GO:0017069 snRNA binding 5/1255 54/18639 0.0925925925925926 1.37516600265604 0.297756235340747 0.784419138857581 GO:0005496 steroid binding 9/1255 108/18639 0.0833333333333333 1.23764940239044 0.303118300774382 0.796666216388198 GO:0005416 amino acid:monoatomic cation symporter activity 3/1255 29/18639 0.103448275862069 1.53639236158813 0.309911403126563 0.804421573794197 GO:0098632 cell-cell adhesion mediator activity 5/1255 55/18639 0.0909090909090909 1.35016298442593 0.311184820607329 0.804421573794197 GO:0140313 molecular sequestering activity 5/1255 55/18639 0.0909090909090909 1.35016298442593 0.311184820607329 0.804421573794197 GO:0016859 cis-trans isomerase activity 4/1255 42/18639 0.0952380952380952 1.41445645987479 0.312766316458553 0.804421573794197 GO:0048487 beta-tubulin binding 4/1255 42/18639 0.0952380952380952 1.41445645987479 0.312766316458553 0.804421573794197 GO:0051879 Hsp90 protein binding 4/1255 42/18639 0.0952380952380952 1.41445645987479 0.312766316458553 0.804421573794197 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 2/1255 17/18639 0.117647058823529 1.74726974455121 0.319032011809158 0.804421573794197 GO:0004659 prenyltransferase activity 2/1255 17/18639 0.117647058823529 1.74726974455121 0.319032011809158 0.804421573794197 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 2/1255 17/18639 0.117647058823529 1.74726974455121 0.319032011809158 0.804421573794197 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 2/1255 17/18639 0.117647058823529 1.74726974455121 0.319032011809158 0.804421573794197 GO:0008569 minus-end-directed microtubule motor activity 2/1255 17/18639 0.117647058823529 1.74726974455121 0.319032011809158 0.804421573794197 GO:0019198 transmembrane receptor protein phosphatase activity 2/1255 17/18639 0.117647058823529 1.74726974455121 0.319032011809158 0.804421573794197 GO:0031489 myosin V binding 2/1255 17/18639 0.117647058823529 1.74726974455121 0.319032011809158 0.804421573794197 GO:0032183 SUMO binding 2/1255 17/18639 0.117647058823529 1.74726974455121 0.319032011809158 0.804421573794197 GO:0048038 quinone binding 2/1255 17/18639 0.117647058823529 1.74726974455121 0.319032011809158 0.804421573794197 GO:0070402 NADPH binding 2/1255 17/18639 0.117647058823529 1.74726974455121 0.319032011809158 0.804421573794197 GO:1901567 fatty acid derivative binding 2/1255 17/18639 0.117647058823529 1.74726974455121 0.319032011809158 0.804421573794197 GO:1990226 histone methyltransferase binding 2/1255 17/18639 0.117647058823529 1.74726974455121 0.319032011809158 0.804421573794197 GO:0004222 metalloendopeptidase activity 9/1255 110/18639 0.0818181818181818 1.21514668598334 0.322031762391625 0.810156483314065 GO:0008135 translation factor activity, RNA binding 7/1255 83/18639 0.0843373493975904 1.25256084097346 0.325376317224541 0.816731115370363 GO:0046906 tetrapyrrole binding 12/1255 152/18639 0.0789473684210526 1.17250996015936 0.326567804626094 0.817883941182392 GO:0001968 fibronectin binding 3/1255 30/18639 0.1 1.48517928286853 0.328797841781107 0.817967013963244 GO:0022839 monoatomic ion-gated channel activity 3/1255 30/18639 0.1 1.48517928286853 0.328797841781107 0.817967013963244 GO:0031210 phosphatidylcholine binding 3/1255 30/18639 0.1 1.48517928286853 0.328797841781107 0.817967013963244 GO:0030295 protein kinase activator activity 11/1255 139/18639 0.079136690647482 1.17532173464416 0.334174460054337 0.827251218432318 GO:0070851 growth factor receptor binding 11/1255 139/18639 0.079136690647482 1.17532173464416 0.334174460054337 0.827251218432318 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 14/1255 181/18639 0.0773480662983425 1.1487574563624 0.334751612114063 0.827251218432318 GO:0180051 translation factor activity 7/1255 84/18639 0.0833333333333333 1.23764940239044 0.336448973113589 0.829610381827547 GO:0005200 structural constituent of cytoskeleton 9/1255 112/18639 0.0803571428571429 1.19344763801935 0.341169577453699 0.834261371881767 GO:0016247 channel regulator activity 13/1255 168/18639 0.0773809523809524 1.14924587364826 0.342673705023701 0.834261371881767 GO:0004713 protein tyrosine kinase activity 11/1255 140/18639 0.0785714285714286 1.1669265793967 0.342747336588901 0.834261371881767 GO:0005506 iron ion binding 12/1255 154/18639 0.0779220779220779 1.15728255807937 0.342862533359968 0.834261371881767 GO:0003954 NADH dehydrogenase activity 4/1255 44/18639 0.0909090909090909 1.35016298442593 0.343973009089378 0.834261371881767 GO:0030547 signaling receptor inhibitor activity 4/1255 44/18639 0.0909090909090909 1.35016298442593 0.343973009089378 0.834261371881767 GO:0000900 mRNA regulatory element binding translation repressor activity 2/1255 18/18639 0.111111111111111 1.65019920318725 0.344310199138312 0.834261371881767 GO:0050811 GABA receptor binding 2/1255 18/18639 0.111111111111111 1.65019920318725 0.344310199138312 0.834261371881767 GO:0017147 Wnt-protein binding 3/1255 31/18639 0.0967741935483871 1.43727027374373 0.347671884049072 0.840583321391371 GO:0042826 histone deacetylase binding 10/1255 127/18639 0.078740157480315 1.16943250619569 0.351312726674308 0.847551437786613 GO:0019887 protein kinase regulator activity 19/1255 255/18639 0.0745098039215686 1.1066041715491 0.357211605375127 0.852230203226421 GO:0141108 transporter regulator activity 13/1255 170/18639 0.0764705882352941 1.13572533395828 0.358402178200306 0.852230203226421 GO:0004715 non-membrane spanning protein tyrosine kinase activity 4/1255 45/18639 0.0888888888888889 1.3201593625498 0.359612437472841 0.852230203226421 GO:0020037 heme binding 11/1255 142/18639 0.0774647887323944 1.15049099377139 0.360004333509427 0.852230203226421 GO:0005539 glycosaminoglycan binding 18/1255 242/18639 0.0743801652892562 1.1046788054394 0.365458304491218 0.852230203226421 GO:0045309 protein phosphorylated amino acid binding 5/1255 59/18639 0.0847457627118644 1.25862651090553 0.365506960164413 0.852230203226421 GO:0070888 E-box binding 5/1255 59/18639 0.0847457627118644 1.25862651090553 0.365506960164413 0.852230203226421 GO:0043425 bHLH transcription factor binding 3/1255 32/18639 0.09375 1.39235557768924 0.366490104995359 0.852230203226421 GO:0051059 NF-kappaB binding 3/1255 32/18639 0.09375 1.39235557768924 0.366490104995359 0.852230203226421 GO:0120015 sterol transfer activity 3/1255 32/18639 0.09375 1.39235557768924 0.366490104995359 0.852230203226421 GO:0140142 nucleocytoplasmic carrier activity 3/1255 32/18639 0.09375 1.39235557768924 0.366490104995359 0.852230203226421 GO:0043539 protein serine/threonine kinase activator activity 6/1255 73/18639 0.0821917808219178 1.22069530098783 0.368514959147316 0.852230203226421 GO:0005229 intracellularly calcium-gated chloride channel activity 2/1255 19/18639 0.105263157894737 1.56334661354582 0.369274322615567 0.852230203226421 GO:0016918 retinal binding 2/1255 19/18639 0.105263157894737 1.56334661354582 0.369274322615567 0.852230203226421 GO:0030506 ankyrin binding 2/1255 19/18639 0.105263157894737 1.56334661354582 0.369274322615567 0.852230203226421 GO:0042577 lipid phosphatase activity 2/1255 19/18639 0.105263157894737 1.56334661354582 0.369274322615567 0.852230203226421 GO:0043395 heparan sulfate proteoglycan binding 2/1255 19/18639 0.105263157894737 1.56334661354582 0.369274322615567 0.852230203226421 GO:0046624 sphingolipid transporter activity 2/1255 19/18639 0.105263157894737 1.56334661354582 0.369274322615567 0.852230203226421 GO:0050145 nucleoside monophosphate kinase activity 2/1255 19/18639 0.105263157894737 1.56334661354582 0.369274322615567 0.852230203226421 GO:0140036 ubiquitin-modified protein reader activity 2/1255 19/18639 0.105263157894737 1.56334661354582 0.369274322615567 0.852230203226421 GO:0141147 intracellularly calcium-gated channel activity 2/1255 19/18639 0.105263157894737 1.56334661354582 0.369274322615567 0.852230203226421 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 4/1255 46/18639 0.0869565217391304 1.29146024597263 0.375241592410748 0.864216203552175 GO:0019207 kinase regulator activity 21/1255 287/18639 0.0731707317073171 1.08671654844038 0.378442556024599 0.86963151769227 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 5/1255 60/18639 0.0833333333333333 1.23764940239044 0.379149999208716 0.86963151769227 GO:0000287 magnesium ion binding 17/1255 230/18639 0.0739130434782609 1.09774120907674 0.381013633712246 0.87061633892638 GO:0016651 oxidoreductase activity, acting on NAD(P)H 7/1255 88/18639 0.0795454545454545 1.18139261137269 0.381138218205013 0.87061633892638 GO:0019956 chemokine binding 3/1255 33/18639 0.0909090909090909 1.35016298442593 0.385212247530838 0.878126694881523 GO:0008194 UDP-glycosyltransferase activity 11/1255 145/18639 0.0758620689655172 1.1266877318313 0.3860995363307 0.878356786316481 GO:0005262 calcium channel activity 10/1255 131/18639 0.0763358778625954 1.13372464341109 0.387942818217556 0.879865583721332 GO:0099106 ion channel regulator activity 12/1255 160/18639 0.075 1.11388446215139 0.392503943419814 0.879865583721332 GO:0019003 GDP binding 6/1255 75/18639 0.08 1.18814342629482 0.393027139833681 0.879865583721332 GO:0001972 retinoic acid binding 2/1255 20/18639 0.1 1.48517928286853 0.393852096562816 0.879865583721332 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 2/1255 20/18639 0.1 1.48517928286853 0.393852096562816 0.879865583721332 GO:0005326 neurotransmitter transmembrane transporter activity 2/1255 20/18639 0.1 1.48517928286853 0.393852096562816 0.879865583721332 GO:0016408 C-acyltransferase activity 2/1255 20/18639 0.1 1.48517928286853 0.393852096562816 0.879865583721332 GO:0043024 ribosomal small subunit binding 2/1255 20/18639 0.1 1.48517928286853 0.393852096562816 0.879865583721332 GO:0140664 ATP-dependent DNA damage sensor activity 2/1255 20/18639 0.1 1.48517928286853 0.393852096562816 0.879865583721332 GO:0033218 amide binding 18/1255 247/18639 0.0728744939271255 1.08231688630095 0.398909196145603 0.889384375438401 GO:0042578 phosphoric ester hydrolase activity 26/1255 363/18639 0.0716253443526171 1.06376477560831 0.400652132625222 0.891490900682018 GO:0015085 calcium ion transmembrane transporter activity 11/1255 147/18639 0.0748299319727891 1.11135864704448 0.403583505013119 0.8931602262212 GO:0008376 acetylgalactosaminyltransferase activity 3/1255 34/18639 0.0882352941176471 1.31045230841341 0.403801176581652 0.8931602262212 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 3/1255 34/18639 0.0882352941176471 1.31045230841341 0.403801176581652 0.8931602262212 GO:0016879 ligase activity, forming carbon-nitrogen bonds 4/1255 48/18639 0.0833333333333333 1.23764940239044 0.406373227303732 0.897072914818714 GO:0008083 growth factor activity 12/1255 162/18639 0.0740740740740741 1.10013280212483 0.409198914858791 0.901528970211576 GO:0009931 calcium-dependent protein serine/threonine kinase activity 2/1255 21/18639 0.0952380952380952 1.41445645987479 0.417982377875224 0.913671851441536 GO:0009975 cyclase activity 2/1255 21/18639 0.0952380952380952 1.41445645987479 0.417982377875224 0.913671851441536 GO:0035613 RNA stem-loop binding 2/1255 21/18639 0.0952380952380952 1.41445645987479 0.417982377875224 0.913671851441536 GO:0072542 protein phosphatase activator activity 2/1255 21/18639 0.0952380952380952 1.41445645987479 0.417982377875224 0.913671851441536 GO:0016763 pentosyltransferase activity 4/1255 49/18639 0.0816326530612245 1.21239125132125 0.421830855610506 0.919342849625696 GO:0005154 epidermal growth factor receptor binding 3/1255 35/18639 0.0857142857142857 1.27301081388731 0.422222812764532 0.919342849625696 GO:0019199 transmembrane receptor protein kinase activity 6/1255 78/18639 0.0769230769230769 1.14244560220656 0.429706960591471 0.921435774606555 GO:0019842 vitamin binding 11/1255 150/18639 0.0733333333333333 1.08913147410359 0.429851861850056 0.921435774606555 GO:0019888 protein phosphatase regulator activity 8/1255 107/18639 0.0747663551401869 1.11041441709796 0.432809443023887 0.921435774606555 GO:0099094 ligand-gated monoatomic cation channel activity 10/1255 136/18639 0.0735294117647059 1.0920435903445 0.43401222047114 0.921435774606555 GO:0140789 histone phosphatase activity 10/1255 136/18639 0.0735294117647059 1.0920435903445 0.43401222047114 0.921435774606555 GO:0004869 cysteine-type endopeptidase inhibitor activity 3/1255 36/18639 0.0833333333333333 1.23764940239044 0.440446049355206 0.921435774606555 GO:0055106 ubiquitin-protein transferase regulator activity 3/1255 36/18639 0.0833333333333333 1.23764940239044 0.440446049355206 0.921435774606555 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 3/1255 36/18639 0.0833333333333333 1.23764940239044 0.440446049355206 0.921435774606555 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 3/1255 36/18639 0.0833333333333333 1.23764940239044 0.440446049355206 0.921435774606555 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 3/1255 36/18639 0.0833333333333333 1.23764940239044 0.440446049355206 0.921435774606555 GO:0008093 cytoskeletal anchor activity 2/1255 22/18639 0.0909090909090909 1.35016298442593 0.441613995220774 0.921435774606555 GO:0034062 5'-3' RNA polymerase activity 2/1255 22/18639 0.0909090909090909 1.35016298442593 0.441613995220774 0.921435774606555 GO:0061133 endopeptidase activator activity 2/1255 22/18639 0.0909090909090909 1.35016298442593 0.441613995220774 0.921435774606555 GO:0097747 RNA polymerase activity 2/1255 22/18639 0.0909090909090909 1.35016298442593 0.441613995220774 0.921435774606555 GO:0140035 ubiquitin-like protein reader activity 2/1255 22/18639 0.0909090909090909 1.35016298442593 0.441613995220774 0.921435774606555 GO:0120013 lipid transfer activity 5/1255 65/18639 0.0769230769230769 1.14244560220656 0.446920386838393 0.921435774606555 GO:0003743 translation initiation factor activity 4/1255 51/18639 0.0784313725490196 1.16484649636747 0.452426994056155 0.921435774606555 GO:0005048 signal sequence binding 4/1255 51/18639 0.0784313725490196 1.16484649636747 0.452426994056155 0.921435774606555 GO:0042805 actinin binding 3/1255 37/18639 0.0810810810810811 1.20419941854205 0.458442655865624 0.921435774606555 GO:0043394 proteoglycan binding 3/1255 37/18639 0.0810810810810811 1.20419941854205 0.458442655865624 0.921435774606555 GO:0004867 serine-type endopeptidase inhibitor activity 7/1255 95/18639 0.0736842105263158 1.09434262948207 0.459428584144741 0.921435774606555 GO:0008235 metalloexopeptidase activity 5/1255 66/18639 0.0757575757575758 1.12513582035494 0.460282511159413 0.921435774606555 GO:0004602 glutathione peroxidase activity 2/1255 23/18639 0.0869565217391304 1.29146024597263 0.464704685191638 0.921435774606555 GO:0005283 amino acid:sodium symporter activity 2/1255 23/18639 0.0869565217391304 1.29146024597263 0.464704685191638 0.921435774606555 GO:0016849 phosphorus-oxygen lyase activity 2/1255 23/18639 0.0869565217391304 1.29146024597263 0.464704685191638 0.921435774606555 GO:0001618 virus receptor activity 6/1255 81/18639 0.0740740740740741 1.10013280212483 0.466015006819457 0.921435774606555 GO:0008237 metallopeptidase activity 13/1255 184/18639 0.0706521739130435 1.04931144985276 0.470151703294175 0.921435774606555 GO:0042162 telomeric DNA binding 3/1255 38/18639 0.0789473684210526 1.17250996015936 0.476187171124142 0.921435774606555 GO:0043531 ADP binding 3/1255 38/18639 0.0789473684210526 1.17250996015936 0.476187171124142 0.921435774606555 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 6/1255 82/18639 0.0731707317073171 1.08671654844038 0.477987501170674 0.921435774606555 GO:0140272 exogenous protein binding 6/1255 82/18639 0.0731707317073171 1.08671654844038 0.477987501170674 0.921435774606555 GO:0004864 protein phosphatase inhibitor activity 4/1255 53/18639 0.0754716981132075 1.12089002480643 0.482475317245174 0.921435774606555 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 5/1255 68/18639 0.0735294117647059 1.0920435903445 0.486708982813152 0.921435774606555 GO:0030145 manganese ion binding 5/1255 68/18639 0.0735294117647059 1.0920435903445 0.486708982813152 0.921435774606555 GO:0032934 sterol binding 5/1255 68/18639 0.0735294117647059 1.0920435903445 0.486708982813152 0.921435774606555 GO:0004806 triacylglycerol lipase activity 2/1255 24/18639 0.0833333333333333 1.23764940239044 0.487220126330187 0.921435774606555 GO:0005540 hyaluronic acid binding 2/1255 24/18639 0.0833333333333333 1.23764940239044 0.487220126330187 0.921435774606555 GO:0030215 semaphorin receptor binding 2/1255 24/18639 0.0833333333333333 1.23764940239044 0.487220126330187 0.921435774606555 GO:0070300 phosphatidic acid binding 2/1255 24/18639 0.0833333333333333 1.23764940239044 0.487220126330187 0.921435774606555 GO:0004725 protein tyrosine phosphatase activity 7/1255 98/18639 0.0714285714285714 1.06084234490609 0.492411021928864 0.921435774606555 GO:0050661 NADP binding 4/1255 54/18639 0.0740740740740741 1.10013280212483 0.497252843797528 0.921435774606555 GO:0051287 NAD binding 4/1255 54/18639 0.0740740740740741 1.10013280212483 0.497252843797528 0.921435774606555 GO:0000182 rDNA binding 1/1255 10/18639 0.1 1.48517928286853 0.502039002817491 0.921435774606555 GO:0001094 TFIID-class transcription factor complex binding 1/1255 10/18639 0.1 1.48517928286853 0.502039002817491 0.921435774606555 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 1/1255 10/18639 0.1 1.48517928286853 0.502039002817491 0.921435774606555 GO:0003680 minor groove of adenine-thymine-rich DNA binding 1/1255 10/18639 0.1 1.48517928286853 0.502039002817491 0.921435774606555 GO:0004090 carbonyl reductase (NADPH) activity 1/1255 10/18639 0.1 1.48517928286853 0.502039002817491 0.921435774606555 GO:0004382 GDP phosphatase activity 1/1255 10/18639 0.1 1.48517928286853 0.502039002817491 0.921435774606555 GO:0004935 adrenergic receptor activity 1/1255 10/18639 0.1 1.48517928286853 0.502039002817491 0.921435774606555 GO:0005031 tumor necrosis factor receptor activity 1/1255 10/18639 0.1 1.48517928286853 0.502039002817491 0.921435774606555 GO:0005337 nucleoside transmembrane transporter activity 1/1255 10/18639 0.1 1.48517928286853 0.502039002817491 0.921435774606555 GO:0005381 iron ion transmembrane transporter activity 1/1255 10/18639 0.1 1.48517928286853 0.502039002817491 0.921435774606555 GO:0005528 FK506 binding 1/1255 10/18639 0.1 1.48517928286853 0.502039002817491 0.921435774606555 GO:0008190 eukaryotic initiation factor 4E binding 1/1255 10/18639 0.1 1.48517928286853 0.502039002817491 0.921435774606555 GO:0008401 retinoic acid 4-hydroxylase activity 1/1255 10/18639 0.1 1.48517928286853 0.502039002817491 0.921435774606555 GO:0008519 ammonium channel activity 1/1255 10/18639 0.1 1.48517928286853 0.502039002817491 0.921435774606555 GO:0015187 glycine transmembrane transporter activity 1/1255 10/18639 0.1 1.48517928286853 0.502039002817491 0.921435774606555 GO:0015203 polyamine transmembrane transporter activity 1/1255 10/18639 0.1 1.48517928286853 0.502039002817491 0.921435774606555 GO:0015279 store-operated calcium channel activity 1/1255 10/18639 0.1 1.48517928286853 0.502039002817491 0.921435774606555 GO:0015658 branched-chain amino acid transmembrane transporter activity 1/1255 10/18639 0.1 1.48517928286853 0.502039002817491 0.921435774606555 GO:0016175 superoxide-generating NAD(P)H oxidase activity 1/1255 10/18639 0.1 1.48517928286853 0.502039002817491 0.921435774606555 GO:0019911 structural constituent of myelin sheath 1/1255 10/18639 0.1 1.48517928286853 0.502039002817491 0.921435774606555 GO:0031419 cobalamin binding 1/1255 10/18639 0.1 1.48517928286853 0.502039002817491 0.921435774606555 GO:0031720 haptoglobin binding 1/1255 10/18639 0.1 1.48517928286853 0.502039002817491 0.921435774606555 GO:0031956 medium-chain fatty acid-CoA ligase activity 1/1255 10/18639 0.1 1.48517928286853 0.502039002817491 0.921435774606555 GO:0032356 oxidized DNA binding 1/1255 10/18639 0.1 1.48517928286853 0.502039002817491 0.921435774606555 GO:0042975 peroxisome proliferator activated receptor binding 1/1255 10/18639 0.1 1.48517928286853 0.502039002817491 0.921435774606555 GO:0043121 neurotrophin binding 1/1255 10/18639 0.1 1.48517928286853 0.502039002817491 0.921435774606555 GO:0043295 glutathione binding 1/1255 10/18639 0.1 1.48517928286853 0.502039002817491 0.921435774606555 GO:0043422 protein kinase B binding 1/1255 10/18639 0.1 1.48517928286853 0.502039002817491 0.921435774606555 GO:0045322 unmethylated CpG binding 1/1255 10/18639 0.1 1.48517928286853 0.502039002817491 0.921435774606555 GO:0047429 nucleoside triphosphate diphosphatase activity 1/1255 10/18639 0.1 1.48517928286853 0.502039002817491 0.921435774606555 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 1/1255 10/18639 0.1 1.48517928286853 0.502039002817491 0.921435774606555 GO:0070739 protein-glutamic acid ligase activity 1/1255 10/18639 0.1 1.48517928286853 0.502039002817491 0.921435774606555 GO:0070740 tubulin-glutamic acid ligase activity 1/1255 10/18639 0.1 1.48517928286853 0.502039002817491 0.921435774606555 GO:0099122 RNA polymerase II C-terminal domain binding 1/1255 10/18639 0.1 1.48517928286853 0.502039002817491 0.921435774606555 GO:0141109 transporter activator activity 1/1255 10/18639 0.1 1.48517928286853 0.502039002817491 0.921435774606555 GO:1905394 retromer complex binding 1/1255 10/18639 0.1 1.48517928286853 0.502039002817491 0.921435774606555 GO:0042974 nuclear retinoic acid receptor binding 2/1255 25/18639 0.08 1.18814342629482 0.509133062688521 0.921435774606555 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 2/1255 25/18639 0.08 1.18814342629482 0.509133062688521 0.921435774606555 GO:0120020 cholesterol transfer activity 2/1255 25/18639 0.08 1.18814342629482 0.509133062688521 0.921435774606555 GO:0050997 quaternary ammonium group binding 3/1255 40/18639 0.075 1.11388446215139 0.510831234589204 0.921435774606555 GO:0042277 peptide binding 17/1255 249/18639 0.0682730923694779 1.01397782364518 0.512634391557672 0.921435774606555 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 6/1255 86/18639 0.0697674418604651 1.03617159269897 0.524985142159604 0.921435774606555 GO:0019212 phosphatase inhibitor activity 4/1255 56/18639 0.0714285714285714 1.06084234490609 0.526242865295596 0.921435774606555 GO:0015175 neutral L-amino acid transmembrane transporter activity 3/1255 41/18639 0.0731707317073171 1.08671654844038 0.527692645839542 0.921435774606555 GO:0001637 G protein-coupled chemoattractant receptor activity 2/1255 26/18639 0.0769230769230769 1.14244560220656 0.53042250925859 0.921435774606555 GO:0004435 phosphatidylinositol phospholipase C activity 2/1255 26/18639 0.0769230769230769 1.14244560220656 0.53042250925859 0.921435774606555 GO:0004950 chemokine receptor activity 2/1255 26/18639 0.0769230769230769 1.14244560220656 0.53042250925859 0.921435774606555 GO:0005112 Notch binding 2/1255 26/18639 0.0769230769230769 1.14244560220656 0.53042250925859 0.921435774606555 GO:0008198 ferrous iron binding 2/1255 26/18639 0.0769230769230769 1.14244560220656 0.53042250925859 0.921435774606555 GO:0043548 phosphatidylinositol 3-kinase binding 2/1255 26/18639 0.0769230769230769 1.14244560220656 0.53042250925859 0.921435774606555 GO:0051139 metal cation:proton antiporter activity 2/1255 26/18639 0.0769230769230769 1.14244560220656 0.53042250925859 0.921435774606555 GO:0008238 exopeptidase activity 7/1255 102/18639 0.0686274509803922 1.01924068432154 0.535367596877627 0.921435774606555 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 1/1255 11/18639 0.0909090909090909 1.35016298442593 0.535585680119764 0.921435774606555 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 1/1255 11/18639 0.0909090909090909 1.35016298442593 0.535585680119764 0.921435774606555 GO:0003953 NAD+ nucleosidase activity 1/1255 11/18639 0.0909090909090909 1.35016298442593 0.535585680119764 0.921435774606555 GO:0004016 adenylate cyclase activity 1/1255 11/18639 0.0909090909090909 1.35016298442593 0.535585680119764 0.921435774606555 GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity 1/1255 11/18639 0.0909090909090909 1.35016298442593 0.535585680119764 0.921435774606555 GO:0008199 ferric iron binding 1/1255 11/18639 0.0909090909090909 1.35016298442593 0.535585680119764 0.921435774606555 GO:0010854 adenylate cyclase regulator activity 1/1255 11/18639 0.0909090909090909 1.35016298442593 0.535585680119764 0.921435774606555 GO:0015217 ADP transmembrane transporter activity 1/1255 11/18639 0.0909090909090909 1.35016298442593 0.535585680119764 0.921435774606555 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 1/1255 11/18639 0.0909090909090909 1.35016298442593 0.535585680119764 0.921435774606555 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 1/1255 11/18639 0.0909090909090909 1.35016298442593 0.535585680119764 0.921435774606555 GO:0019215 intermediate filament binding 1/1255 11/18639 0.0909090909090909 1.35016298442593 0.535585680119764 0.921435774606555 GO:0032404 mismatch repair complex binding 1/1255 11/18639 0.0909090909090909 1.35016298442593 0.535585680119764 0.921435774606555 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 1/1255 11/18639 0.0909090909090909 1.35016298442593 0.535585680119764 0.921435774606555 GO:0042608 T cell receptor binding 1/1255 11/18639 0.0909090909090909 1.35016298442593 0.535585680119764 0.921435774606555 GO:0045294 alpha-catenin binding 1/1255 11/18639 0.0909090909090909 1.35016298442593 0.535585680119764 0.921435774606555 GO:0047676 arachidonate-CoA ligase activity 1/1255 11/18639 0.0909090909090909 1.35016298442593 0.535585680119764 0.921435774606555 GO:0048101 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity 1/1255 11/18639 0.0909090909090909 1.35016298442593 0.535585680119764 0.921435774606555 GO:0050786 RAGE receptor binding 1/1255 11/18639 0.0909090909090909 1.35016298442593 0.535585680119764 0.921435774606555 GO:0070697 activin receptor binding 1/1255 11/18639 0.0909090909090909 1.35016298442593 0.535585680119764 0.921435774606555 GO:0070990 snRNP binding 1/1255 11/18639 0.0909090909090909 1.35016298442593 0.535585680119764 0.921435774606555 GO:0140031 phosphorylation-dependent protein binding 1/1255 11/18639 0.0909090909090909 1.35016298442593 0.535585680119764 0.921435774606555 GO:0140537 transcription regulator activator activity 1/1255 11/18639 0.0909090909090909 1.35016298442593 0.535585680119764 0.921435774606555 GO:1900750 oligopeptide binding 1/1255 11/18639 0.0909090909090909 1.35016298442593 0.535585680119764 0.921435774606555 GO:1990948 ubiquitin ligase inhibitor activity 1/1255 11/18639 0.0909090909090909 1.35016298442593 0.535585680119764 0.921435774606555 GO:0016504 peptidase activator activity 4/1255 57/18639 0.0701754385964912 1.04223107569721 0.54043018827922 0.921435774606555 GO:0004520 DNA endonuclease activity 3/1255 42/18639 0.0714285714285714 1.06084234490609 0.544225440407311 0.921435774606555 GO:0004521 RNA endonuclease activity 5/1255 73/18639 0.0684931506849315 1.01724608415652 0.550523871814281 0.921435774606555 GO:0004364 glutathione transferase activity 2/1255 27/18639 0.0740740740740741 1.10013280212483 0.551073032234717 0.921435774606555 GO:0005104 fibroblast growth factor receptor binding 2/1255 27/18639 0.0740740740740741 1.10013280212483 0.551073032234717 0.921435774606555 GO:0005385 zinc ion transmembrane transporter activity 2/1255 27/18639 0.0740740740740741 1.10013280212483 0.551073032234717 0.921435774606555 GO:0016405 CoA-ligase activity 2/1255 27/18639 0.0740740740740741 1.10013280212483 0.551073032234717 0.921435774606555 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 2/1255 27/18639 0.0740740740740741 1.10013280212483 0.551073032234717 0.921435774606555 GO:0016853 isomerase activity 12/1255 180/18639 0.0666666666666667 0.990119521912351 0.557068573692238 0.921435774606555 GO:0003924 GTPase activity 22/1255 331/18639 0.0664652567975831 0.987128224263069 0.557211894987434 0.921435774606555 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 6/1255 89/18639 0.0674157303370786 1.0012444603608 0.559076012156413 0.921435774606555 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 6/1255 89/18639 0.0674157303370786 1.0012444603608 0.559076012156413 0.921435774606555 GO:0004712 protein serine/threonine/tyrosine kinase activity 3/1255 43/18639 0.0697674418604651 1.03617159269897 0.560416190951314 0.921435774606555 GO:0005245 voltage-gated calcium channel activity 3/1255 43/18639 0.0697674418604651 1.03617159269897 0.560416190951314 0.921435774606555 GO:0008375 acetylglucosaminyltransferase activity 3/1255 43/18639 0.0697674418604651 1.03617159269897 0.560416190951314 0.921435774606555 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 3/1255 43/18639 0.0697674418604651 1.03617159269897 0.560416190951314 0.921435774606555 GO:0048029 monosaccharide binding 5/1255 74/18639 0.0675675675675676 1.00349951545171 0.562824939262418 0.921435774606555 GO:0000995 RNA polymerase III general transcription initiation factor activity 1/1255 12/18639 0.0833333333333333 1.23764940239044 0.566874061666344 0.921435774606555 GO:0003720 telomerase activity 1/1255 12/18639 0.0833333333333333 1.23764940239044 0.566874061666344 0.921435774606555 GO:0003995 acyl-CoA dehydrogenase activity 1/1255 12/18639 0.0833333333333333 1.23764940239044 0.566874061666344 0.921435774606555 GO:0004000 adenosine deaminase activity 1/1255 12/18639 0.0833333333333333 1.23764940239044 0.566874061666344 0.921435774606555 GO:0004300 enoyl-CoA hydratase activity 1/1255 12/18639 0.0833333333333333 1.23764940239044 0.566874061666344 0.921435774606555 GO:0004859 phospholipase inhibitor activity 1/1255 12/18639 0.0833333333333333 1.23764940239044 0.566874061666344 0.921435774606555 GO:0004875 complement receptor activity 1/1255 12/18639 0.0833333333333333 1.23764940239044 0.566874061666344 0.921435774606555 GO:0005025 transforming growth factor beta receptor activity, type I 1/1255 12/18639 0.0833333333333333 1.23764940239044 0.566874061666344 0.921435774606555 GO:0005026 transforming growth factor beta receptor activity, type II 1/1255 12/18639 0.0833333333333333 1.23764940239044 0.566874061666344 0.921435774606555 GO:0005247 voltage-gated chloride channel activity 1/1255 12/18639 0.0833333333333333 1.23764940239044 0.566874061666344 0.921435774606555 GO:0005527 macrolide binding 1/1255 12/18639 0.0833333333333333 1.23764940239044 0.566874061666344 0.921435774606555 GO:0015269 calcium-activated potassium channel activity 1/1255 12/18639 0.0833333333333333 1.23764940239044 0.566874061666344 0.921435774606555 GO:0015368 calcium:monoatomic cation antiporter activity 1/1255 12/18639 0.0833333333333333 1.23764940239044 0.566874061666344 0.921435774606555 GO:0016361 activin receptor activity, type I 1/1255 12/18639 0.0833333333333333 1.23764940239044 0.566874061666344 0.921435774606555 GO:0016362 activin receptor activity, type II 1/1255 12/18639 0.0833333333333333 1.23764940239044 0.566874061666344 0.921435774606555 GO:0017002 activin receptor activity 1/1255 12/18639 0.0833333333333333 1.23764940239044 0.566874061666344 0.921435774606555 GO:0035014 phosphatidylinositol 3-kinase regulator activity 1/1255 12/18639 0.0833333333333333 1.23764940239044 0.566874061666344 0.921435774606555 GO:0035251 UDP-glucosyltransferase activity 1/1255 12/18639 0.0833333333333333 1.23764940239044 0.566874061666344 0.921435774606555 GO:0045295 gamma-catenin binding 1/1255 12/18639 0.0833333333333333 1.23764940239044 0.566874061666344 0.921435774606555 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 1/1255 12/18639 0.0833333333333333 1.23764940239044 0.566874061666344 0.921435774606555 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 1/1255 12/18639 0.0833333333333333 1.23764940239044 0.566874061666344 0.921435774606555 GO:0070410 co-SMAD binding 1/1255 12/18639 0.0833333333333333 1.23764940239044 0.566874061666344 0.921435774606555 GO:0097677 STAT family protein binding 1/1255 12/18639 0.0833333333333333 1.23764940239044 0.566874061666344 0.921435774606555 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 1/1255 12/18639 0.0833333333333333 1.23764940239044 0.566874061666344 0.921435774606555 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 1/1255 12/18639 0.0833333333333333 1.23764940239044 0.566874061666344 0.921435774606555 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 1/1255 12/18639 0.0833333333333333 1.23764940239044 0.566874061666344 0.921435774606555 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 1/1255 12/18639 0.0833333333333333 1.23764940239044 0.566874061666344 0.921435774606555 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 1/1255 12/18639 0.0833333333333333 1.23764940239044 0.566874061666344 0.921435774606555 GO:1990817 poly(A) RNA polymerase activity 1/1255 12/18639 0.0833333333333333 1.23764940239044 0.566874061666344 0.921435774606555 GO:0001786 phosphatidylserine binding 4/1255 59/18639 0.0677966101694915 1.00690120872442 0.568134990094978 0.921435774606555 GO:0015459 potassium channel regulator activity 4/1255 59/18639 0.0677966101694915 1.00690120872442 0.568134990094978 0.921435774606555 GO:0031593 polyubiquitin modification-dependent protein binding 4/1255 59/18639 0.0677966101694915 1.00690120872442 0.568134990094978 0.921435774606555 GO:0140793 histone H2AXY142 phosphatase activity 6/1255 90/18639 0.0666666666666667 0.990119521912351 0.570182383069836 0.921435774606555 GO:0044325 transmembrane transporter binding 9/1255 136/18639 0.0661764705882353 0.982839231310054 0.570642427782394 0.921435774606555 GO:0005242 inward rectifier potassium channel activity 2/1255 28/18639 0.0714285714285714 1.06084234490609 0.571074097645887 0.921435774606555 GO:0016866 intramolecular transferase activity 2/1255 28/18639 0.0714285714285714 1.06084234490609 0.571074097645887 0.921435774606555 GO:0019789 SUMO transferase activity 2/1255 28/18639 0.0714285714285714 1.06084234490609 0.571074097645887 0.921435774606555 GO:0045499 chemorepellent activity 2/1255 28/18639 0.0714285714285714 1.06084234490609 0.571074097645887 0.921435774606555 GO:0046875 ephrin receptor binding 2/1255 28/18639 0.0714285714285714 1.06084234490609 0.571074097645887 0.921435774606555 GO:0051019 mitogen-activated protein kinase binding 2/1255 28/18639 0.0714285714285714 1.06084234490609 0.571074097645887 0.921435774606555 GO:0051537 2 iron, 2 sulfur cluster binding 2/1255 28/18639 0.0714285714285714 1.06084234490609 0.571074097645887 0.921435774606555 GO:0004540 RNA nuclease activity 8/1255 121/18639 0.0661157024793388 0.981936715946133 0.573385320787137 0.921435774606555 GO:0019205 nucleobase-containing compound kinase activity 3/1255 44/18639 0.0681818181818182 1.01262223831945 0.576253496941211 0.921435774606555 GO:0004629 phospholipase C activity 2/1255 29/18639 0.0689655172413793 1.02426157439209 0.590419482425096 0.921435774606555 GO:0035250 UDP-galactosyltransferase activity 2/1255 29/18639 0.0689655172413793 1.02426157439209 0.590419482425096 0.921435774606555 GO:0046915 transition metal ion transmembrane transporter activity 3/1255 45/18639 0.0666666666666667 0.990119521912351 0.591727858331809 0.921435774606555 GO:0140303 intramembrane lipid transporter activity 3/1255 45/18639 0.0666666666666667 0.990119521912351 0.591727858331809 0.921435774606555 GO:0016836 hydro-lyase activity 4/1255 61/18639 0.0655737704918033 0.973888054340017 0.594886538999814 0.921435774606555 GO:0003964 RNA-directed DNA polymerase activity 1/1255 13/18639 0.0769230769230769 1.14244560220656 0.596056058370523 0.921435774606555 GO:0004465 lipoprotein lipase activity 1/1255 13/18639 0.0769230769230769 1.14244560220656 0.596056058370523 0.921435774606555 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 1/1255 13/18639 0.0769230769230769 1.14244560220656 0.596056058370523 0.921435774606555 GO:0005035 death receptor activity 1/1255 13/18639 0.0769230769230769 1.14244560220656 0.596056058370523 0.921435774606555 GO:0008035 high-density lipoprotein particle binding 1/1255 13/18639 0.0769230769230769 1.14244560220656 0.596056058370523 0.921435774606555 GO:0008253 5'-nucleotidase activity 1/1255 13/18639 0.0769230769230769 1.14244560220656 0.596056058370523 0.921435774606555 GO:0015651 quaternary ammonium group transmembrane transporter activity 1/1255 13/18639 0.0769230769230769 1.14244560220656 0.596056058370523 0.921435774606555 GO:0019855 calcium channel inhibitor activity 1/1255 13/18639 0.0769230769230769 1.14244560220656 0.596056058370523 0.921435774606555 GO:0031994 insulin-like growth factor I binding 1/1255 13/18639 0.0769230769230769 1.14244560220656 0.596056058370523 0.921435774606555 GO:0039706 co-receptor binding 1/1255 13/18639 0.0769230769230769 1.14244560220656 0.596056058370523 0.921435774606555 GO:0043560 insulin receptor substrate binding 1/1255 13/18639 0.0769230769230769 1.14244560220656 0.596056058370523 0.921435774606555 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 1/1255 13/18639 0.0769230769230769 1.14244560220656 0.596056058370523 0.921435774606555 GO:0045159 myosin II binding 1/1255 13/18639 0.0769230769230769 1.14244560220656 0.596056058370523 0.921435774606555 GO:0071837 HMG box domain binding 1/1255 13/18639 0.0769230769230769 1.14244560220656 0.596056058370523 0.921435774606555 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 1/1255 13/18639 0.0769230769230769 1.14244560220656 0.596056058370523 0.921435774606555 GO:0140410 monoatomic cation:bicarbonate symporter activity 1/1255 13/18639 0.0769230769230769 1.14244560220656 0.596056058370523 0.921435774606555 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 1/1255 13/18639 0.0769230769230769 1.14244560220656 0.596056058370523 0.921435774606555 GO:1901338 catecholamine binding 1/1255 13/18639 0.0769230769230769 1.14244560220656 0.596056058370523 0.921435774606555 GO:0015276 ligand-gated monoatomic ion channel activity 12/1255 186/18639 0.0645161290322581 0.958180182495823 0.603429477871364 0.921435774606555 GO:0030291 protein serine/threonine kinase inhibitor activity 3/1255 46/18639 0.0652173913043478 0.968595184479473 0.606831551303046 0.921435774606555 GO:0015179 L-amino acid transmembrane transporter activity 4/1255 62/18639 0.0645161290322581 0.958180182495823 0.607886080533541 0.921435774606555 GO:0015215 nucleotide transmembrane transporter activity 2/1255 30/18639 0.0666666666666667 0.990119521912351 0.609106742471095 0.921435774606555 GO:0022834 ligand-gated channel activity 12/1255 188/18639 0.0638297872340425 0.947986776299059 0.618376654636694 0.921435774606555 GO:0001784 phosphotyrosine residue binding 3/1255 47/18639 0.0638297872340425 0.947986776299059 0.621558506745043 0.921435774606555 GO:0005504 fatty acid binding 3/1255 47/18639 0.0638297872340425 0.947986776299059 0.621558506745043 0.921435774606555 GO:0099095 ligand-gated monoatomic anion channel activity 3/1255 47/18639 0.0638297872340425 0.947986776299059 0.621558506745043 0.921435774606555 GO:0016835 carbon-oxygen lyase activity 5/1255 79/18639 0.0632911392405063 0.939986887891472 0.621615048506504 0.921435774606555 GO:0033293 monocarboxylic acid binding 5/1255 79/18639 0.0632911392405063 0.939986887891472 0.621615048506504 0.921435774606555 GO:0005344 oxygen carrier activity 1/1255 14/18639 0.0714285714285714 1.06084234490609 0.623273370017951 0.921435774606555 GO:0005347 ATP transmembrane transporter activity 1/1255 14/18639 0.0714285714285714 1.06084234490609 0.623273370017951 0.921435774606555 GO:0008174 mRNA methyltransferase activity 1/1255 14/18639 0.0714285714285714 1.06084234490609 0.623273370017951 0.921435774606555 GO:0008474 palmitoyl-(protein) hydrolase activity 1/1255 14/18639 0.0714285714285714 1.06084234490609 0.623273370017951 0.921435774606555 GO:0008494 translation activator activity 1/1255 14/18639 0.0714285714285714 1.06084234490609 0.623273370017951 0.921435774606555 GO:0015386 potassium:proton antiporter activity 1/1255 14/18639 0.0714285714285714 1.06084234490609 0.623273370017951 0.921435774606555 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 1/1255 14/18639 0.0714285714285714 1.06084234490609 0.623273370017951 0.921435774606555 GO:0019992 diacylglycerol binding 1/1255 14/18639 0.0714285714285714 1.06084234490609 0.623273370017951 0.921435774606555 GO:0031404 chloride ion binding 1/1255 14/18639 0.0714285714285714 1.06084234490609 0.623273370017951 0.921435774606555 GO:0042813 Wnt receptor activity 1/1255 14/18639 0.0714285714285714 1.06084234490609 0.623273370017951 0.921435774606555 GO:0044548 S100 protein binding 1/1255 14/18639 0.0714285714285714 1.06084234490609 0.623273370017951 0.921435774606555 GO:0061665 SUMO ligase activity 1/1255 14/18639 0.0714285714285714 1.06084234490609 0.623273370017951 0.921435774606555 GO:0071933 Arp2/3 complex binding 1/1255 14/18639 0.0714285714285714 1.06084234490609 0.623273370017951 0.921435774606555 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 1/1255 14/18639 0.0714285714285714 1.06084234490609 0.623273370017951 0.921435774606555 GO:0098599 palmitoyl hydrolase activity 1/1255 14/18639 0.0714285714285714 1.06084234490609 0.623273370017951 0.921435774606555 GO:0098821 BMP receptor activity 1/1255 14/18639 0.0714285714285714 1.06084234490609 0.623273370017951 0.921435774606555 GO:1901612 cardiolipin binding 1/1255 14/18639 0.0714285714285714 1.06084234490609 0.623273370017951 0.921435774606555 GO:0008327 methyl-CpG binding 2/1255 31/18639 0.0645161290322581 0.958180182495823 0.627136732707096 0.921435774606555 GO:0016878 acid-thiol ligase activity 2/1255 31/18639 0.0645161290322581 0.958180182495823 0.627136732707096 0.921435774606555 GO:0004175 endopeptidase activity 26/1255 405/18639 0.0641975308641975 0.953448428508189 0.629355540418811 0.921435774606555 GO:0043022 ribosome binding 7/1255 112/18639 0.0625 0.928237051792829 0.635390680851221 0.921435774606555 GO:0019955 cytokine binding 9/1255 144/18639 0.0625 0.928237051792829 0.639771018268354 0.921435774606555 GO:0015101 organic cation transmembrane transporter activity 5/1255 81/18639 0.0617283950617284 0.916777335104028 0.643763446955361 0.921435774606555 GO:0033192 calmodulin-dependent protein phosphatase activity 5/1255 81/18639 0.0617283950617284 0.916777335104028 0.643763446955361 0.921435774606555 GO:0140791 histone H2AXS140 phosphatase activity 5/1255 81/18639 0.0617283950617284 0.916777335104028 0.643763446955361 0.921435774606555 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 5/1255 81/18639 0.0617283950617284 0.916777335104028 0.643763446955361 0.921435774606555 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 5/1255 81/18639 0.0617283950617284 0.916777335104028 0.643763446955361 0.921435774606555 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 5/1255 81/18639 0.0617283950617284 0.916777335104028 0.643763446955361 0.921435774606555 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 5/1255 81/18639 0.0617283950617284 0.916777335104028 0.643763446955361 0.921435774606555 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 5/1255 81/18639 0.0617283950617284 0.916777335104028 0.643763446955361 0.921435774606555 GO:1990439 MAP kinase serine/threonine phosphatase activity 5/1255 81/18639 0.0617283950617284 0.916777335104028 0.643763446955361 0.921435774606555 GO:0008378 galactosyltransferase activity 2/1255 32/18639 0.0625 0.928237051792829 0.644513174554545 0.921435774606555 GO:0030515 snoRNA binding 2/1255 32/18639 0.0625 0.928237051792829 0.644513174554545 0.921435774606555 GO:0031369 translation initiation factor binding 2/1255 32/18639 0.0625 0.928237051792829 0.644513174554545 0.921435774606555 GO:0038024 cargo receptor activity 4/1255 65/18639 0.0615384615384615 0.913956481765247 0.645312151137854 0.921435774606555 GO:0000774 adenyl-nucleotide exchange factor activity 1/1255 15/18639 0.0666666666666667 0.990119521912351 0.648658171125467 0.921435774606555 GO:0004089 carbonate dehydratase activity 1/1255 15/18639 0.0666666666666667 0.990119521912351 0.648658171125467 0.921435774606555 GO:0004129 cytochrome-c oxidase activity 1/1255 15/18639 0.0666666666666667 0.990119521912351 0.648658171125467 0.921435774606555 GO:0004467 long-chain fatty acid-CoA ligase activity 1/1255 15/18639 0.0666666666666667 0.990119521912351 0.648658171125467 0.921435774606555 GO:0004865 protein serine/threonine phosphatase inhibitor activity 1/1255 15/18639 0.0666666666666667 0.990119521912351 0.648658171125467 0.921435774606555 GO:0008242 omega peptidase activity 1/1255 15/18639 0.0666666666666667 0.990119521912351 0.648658171125467 0.921435774606555 GO:0008252 nucleotidase activity 1/1255 15/18639 0.0666666666666667 0.990119521912351 0.648658171125467 0.921435774606555 GO:0015556 C4-dicarboxylate transmembrane transporter activity 1/1255 15/18639 0.0666666666666667 0.990119521912351 0.648658171125467 0.921435774606555 GO:0016846 carbon-sulfur lyase activity 1/1255 15/18639 0.0666666666666667 0.990119521912351 0.648658171125467 0.921435774606555 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 1/1255 15/18639 0.0666666666666667 0.990119521912351 0.648658171125467 0.921435774606555 GO:0031005 filamin binding 1/1255 15/18639 0.0666666666666667 0.990119521912351 0.648658171125467 0.921435774606555 GO:0031386 protein tag activity 1/1255 15/18639 0.0666666666666667 0.990119521912351 0.648658171125467 0.921435774606555 GO:0033130 acetylcholine receptor binding 1/1255 15/18639 0.0666666666666667 0.990119521912351 0.648658171125467 0.921435774606555 GO:0047372 monoacylglycerol lipase activity 1/1255 15/18639 0.0666666666666667 0.990119521912351 0.648658171125467 0.921435774606555 GO:0055105 ubiquitin-protein transferase inhibitor activity 1/1255 15/18639 0.0666666666666667 0.990119521912351 0.648658171125467 0.921435774606555 GO:0140161 monocarboxylate:sodium symporter activity 1/1255 15/18639 0.0666666666666667 0.990119521912351 0.648658171125467 0.921435774606555 GO:0141047 molecular tag activity 1/1255 15/18639 0.0666666666666667 0.990119521912351 0.648658171125467 0.921435774606555 GO:0005004 GPI-linked ephrin receptor activity 3/1255 49/18639 0.0612244897959184 0.909293438490934 0.649865496590954 0.921435774606555 GO:0005008 hepatocyte growth factor receptor activity 3/1255 49/18639 0.0612244897959184 0.909293438490934 0.649865496590954 0.921435774606555 GO:0005009 insulin receptor activity 3/1255 49/18639 0.0612244897959184 0.909293438490934 0.649865496590954 0.921435774606555 GO:0005011 macrophage colony-stimulating factor receptor activity 3/1255 49/18639 0.0612244897959184 0.909293438490934 0.649865496590954 0.921435774606555 GO:0005018 platelet-derived growth factor alpha-receptor activity 3/1255 49/18639 0.0612244897959184 0.909293438490934 0.649865496590954 0.921435774606555 GO:0005020 stem cell factor receptor activity 3/1255 49/18639 0.0612244897959184 0.909293438490934 0.649865496590954 0.921435774606555 GO:0008288 boss receptor activity 3/1255 49/18639 0.0612244897959184 0.909293438490934 0.649865496590954 0.921435774606555 GO:0036332 placental growth factor receptor activity 3/1255 49/18639 0.0612244897959184 0.909293438490934 0.649865496590954 0.921435774606555 GO:0038062 protein tyrosine kinase collagen receptor activity 3/1255 49/18639 0.0612244897959184 0.909293438490934 0.649865496590954 0.921435774606555 GO:0060175 brain-derived neurotrophic factor receptor activity 3/1255 49/18639 0.0612244897959184 0.909293438490934 0.649865496590954 0.921435774606555 GO:0033549 MAP kinase phosphatase activity 5/1255 82/18639 0.0609756097560976 0.905597123700321 0.654528118759561 0.921435774606555 GO:0140311 protein sequestering activity 2/1255 33/18639 0.0606060606060606 0.900108656283955 0.661242266620591 0.921435774606555 GO:0005006 epidermal growth factor receptor activity 3/1255 50/18639 0.06 0.891107569721115 0.663440621418941 0.921435774606555 GO:0005007 fibroblast growth factor receptor activity 3/1255 50/18639 0.06 0.891107569721115 0.663440621418941 0.921435774606555 GO:0005017 platelet-derived growth factor receptor activity 3/1255 50/18639 0.06 0.891107569721115 0.663440621418941 0.921435774606555 GO:0005019 platelet-derived growth factor beta-receptor activity 3/1255 50/18639 0.06 0.891107569721115 0.663440621418941 0.921435774606555 GO:0001540 amyloid-beta binding 5/1255 83/18639 0.0602409638554217 0.89468631498104 0.665082531389155 0.921435774606555 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 5/1255 83/18639 0.0602409638554217 0.89468631498104 0.665082531389155 0.921435774606555 GO:0061134 peptidase regulator activity 14/1255 226/18639 0.0619469026548673 0.920022564608821 0.665690450429821 0.921435774606555 GO:0016500 protein-hormone receptor activity 4/1255 67/18639 0.0597014925373134 0.886674198727478 0.668913049240728 0.921435774606555 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 4/1255 67/18639 0.0597014925373134 0.886674198727478 0.668913049240728 0.921435774606555 GO:0009055 electron transfer activity 7/1255 116/18639 0.0603448275862069 0.896228877593076 0.671751295163226 0.921435774606555 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 1/1255 16/18639 0.0625 0.928237051792829 0.672333750766657 0.921435774606555 GO:0015562 efflux transmembrane transporter activity 1/1255 16/18639 0.0625 0.928237051792829 0.672333750766657 0.921435774606555 GO:0016675 oxidoreductase activity, acting on a heme group of donors 1/1255 16/18639 0.0625 0.928237051792829 0.672333750766657 0.921435774606555 GO:0019841 retinol binding 1/1255 16/18639 0.0625 0.928237051792829 0.672333750766657 0.921435774606555 GO:0022841 potassium ion leak channel activity 1/1255 16/18639 0.0625 0.928237051792829 0.672333750766657 0.921435774606555 GO:0030275 LRR domain binding 1/1255 16/18639 0.0625 0.928237051792829 0.672333750766657 0.921435774606555 GO:0043023 ribosomal large subunit binding 1/1255 16/18639 0.0625 0.928237051792829 0.672333750766657 0.921435774606555 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 1/1255 16/18639 0.0625 0.928237051792829 0.672333750766657 0.921435774606555 GO:0055102 lipase inhibitor activity 1/1255 16/18639 0.0625 0.928237051792829 0.672333750766657 0.921435774606555 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 1/1255 16/18639 0.0625 0.928237051792829 0.672333750766657 0.921435774606555 GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential 1/1255 16/18639 0.0625 0.928237051792829 0.672333750766657 0.921435774606555 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 1/1255 16/18639 0.0625 0.928237051792829 0.672333750766657 0.921435774606555 GO:0140327 flippase activity 1/1255 16/18639 0.0625 0.928237051792829 0.672333750766657 0.921435774606555 GO:0140328 floppase activity 1/1255 16/18639 0.0625 0.928237051792829 0.672333750766657 0.921435774606555 GO:0017018 myosin phosphatase activity 5/1255 84/18639 0.0595238095238095 0.884035287421741 0.675424361656155 0.921435774606555 GO:0005010 insulin-like growth factor receptor activity 3/1255 51/18639 0.0588235294117647 0.873634872275604 0.676628973129115 0.921435774606555 GO:0005021 vascular endothelial growth factor receptor activity 3/1255 51/18639 0.0588235294117647 0.873634872275604 0.676628973129115 0.921435774606555 GO:0005030 neurotrophin receptor activity 3/1255 51/18639 0.0588235294117647 0.873634872275604 0.676628973129115 0.921435774606555 GO:0005272 sodium channel activity 3/1255 51/18639 0.0588235294117647 0.873634872275604 0.676628973129115 0.921435774606555 GO:0015020 glucuronosyltransferase activity 2/1255 34/18639 0.0588235294117647 0.873634872275604 0.677332334748025 0.921435774606555 GO:0015035 protein-disulfide reductase activity 2/1255 34/18639 0.0588235294117647 0.873634872275604 0.677332334748025 0.921435774606555 GO:0019825 oxygen binding 2/1255 34/18639 0.0588235294117647 0.873634872275604 0.677332334748025 0.921435774606555 GO:0051427 hormone receptor binding 2/1255 34/18639 0.0588235294117647 0.873634872275604 0.677332334748025 0.921435774606555 GO:0005126 cytokine receptor binding 17/1255 275/18639 0.0618181818181818 0.918110829409634 0.678084339056928 0.921435774606555 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 14/1255 229/18639 0.0611353711790393 0.907969867255867 0.684653803642623 0.924381515399945 GO:0015171 amino acid transmembrane transporter activity 6/1255 102/18639 0.0588235294117647 0.873634872275604 0.691416879227854 0.924381515399945 GO:0005343 organic acid:sodium symporter activity 2/1255 35/18639 0.0571428571428571 0.848673875924872 0.692793517898539 0.924381515399945 GO:0061631 ubiquitin conjugating enzyme activity 2/1255 35/18639 0.0571428571428571 0.848673875924872 0.692793517898539 0.924381515399945 GO:0008429 phosphatidylethanolamine binding 1/1255 17/18639 0.0588235294117647 0.873634872275604 0.694415109451501 0.924381515399945 GO:0016018 cyclosporin A binding 1/1255 17/18639 0.0588235294117647 0.873634872275604 0.694415109451501 0.924381515399945 GO:0016805 dipeptidase activity 1/1255 17/18639 0.0588235294117647 0.873634872275604 0.694415109451501 0.924381515399945 GO:0017110 nucleoside diphosphate phosphatase activity 1/1255 17/18639 0.0588235294117647 0.873634872275604 0.694415109451501 0.924381515399945 GO:0038191 neuropilin binding 1/1255 17/18639 0.0588235294117647 0.873634872275604 0.694415109451501 0.924381515399945 GO:0045125 bioactive lipid receptor activity 1/1255 17/18639 0.0588235294117647 0.873634872275604 0.694415109451501 0.924381515399945 GO:0045236 CXCR chemokine receptor binding 1/1255 17/18639 0.0588235294117647 0.873634872275604 0.694415109451501 0.924381515399945 GO:0046965 nuclear retinoid X receptor binding 1/1255 17/18639 0.0588235294117647 0.873634872275604 0.694415109451501 0.924381515399945 GO:0051787 misfolded protein binding 1/1255 17/18639 0.0588235294117647 0.873634872275604 0.694415109451501 0.924381515399945 GO:0070403 NAD+ binding 1/1255 17/18639 0.0588235294117647 0.873634872275604 0.694415109451501 0.924381515399945 GO:0070492 oligosaccharide binding 1/1255 17/18639 0.0588235294117647 0.873634872275604 0.694415109451501 0.924381515399945 GO:0004722 protein serine/threonine phosphatase activity 6/1255 103/18639 0.058252427184466 0.865152980311763 0.700419036495722 0.924381515399945 GO:0061135 endopeptidase regulator activity 11/1255 184/18639 0.0597826086956522 0.887878919106184 0.701528392844589 0.924381515399945 GO:0005003 ephrin receptor activity 3/1255 53/18639 0.0566037735849057 0.840667518604826 0.701848407103044 0.924381515399945 GO:0005005 transmembrane-ephrin receptor activity 3/1255 53/18639 0.0566037735849057 0.840667518604826 0.701848407103044 0.924381515399945 GO:0005246 calcium channel regulator activity 3/1255 53/18639 0.0566037735849057 0.840667518604826 0.701848407103044 0.924381515399945 GO:0016860 intramolecular oxidoreductase activity 3/1255 53/18639 0.0566037735849057 0.840667518604826 0.701848407103044 0.924381515399945 GO:0038064 collagen receptor activity 3/1255 53/18639 0.0566037735849057 0.840667518604826 0.701848407103044 0.924381515399945 GO:0016779 nucleotidyltransferase activity 8/1255 136/18639 0.0588235294117647 0.873634872275604 0.703589296443009 0.924381515399945 GO:0008081 phosphoric diester hydrolase activity 5/1255 87/18639 0.0574712643678161 0.853551311993406 0.705157914801053 0.924381515399945 GO:0016409 palmitoyltransferase activity 2/1255 36/18639 0.0555555555555556 0.825099601593625 0.707637486636383 0.924381515399945 GO:0015078 proton transmembrane transporter activity 11/1255 185/18639 0.0594594594594595 0.883079573597502 0.708208853472702 0.924381515399945 GO:0030414 peptidase inhibitor activity 10/1255 169/18639 0.0591715976331361 0.87880430938966 0.708650288176414 0.924381515399945 GO:0140299 molecular sensor activity 4/1255 71/18639 0.0563380281690141 0.836720722742831 0.712800852329878 0.924381515399945 GO:0003697 single-stranded DNA binding 7/1255 121/18639 0.0578512396694215 0.859194626452866 0.713901941841934 0.924381515399945 GO:0000400 four-way junction DNA binding 1/1255 18/18639 0.0555555555555556 0.825099601593625 0.715009515940512 0.924381515399945 GO:0003746 translation elongation factor activity 1/1255 18/18639 0.0555555555555556 0.825099601593625 0.715009515940512 0.924381515399945 GO:0004970 glutamate-gated receptor activity 1/1255 18/18639 0.0555555555555556 0.825099601593625 0.715009515940512 0.924381515399945 GO:0008308 voltage-gated monoatomic anion channel activity 1/1255 18/18639 0.0555555555555556 0.825099601593625 0.715009515940512 0.924381515399945 GO:0008525 phosphatidylcholine transporter activity 1/1255 18/18639 0.0555555555555556 0.825099601593625 0.715009515940512 0.924381515399945 GO:0015280 ligand-gated sodium channel activity 1/1255 18/18639 0.0555555555555556 0.825099601593625 0.715009515940512 0.924381515399945 GO:0016854 racemase and epimerase activity 1/1255 18/18639 0.0555555555555556 0.825099601593625 0.715009515940512 0.924381515399945 GO:0022851 GABA-gated chloride ion channel activity 1/1255 18/18639 0.0555555555555556 0.825099601593625 0.715009515940512 0.924381515399945 GO:0032393 MHC class I receptor activity 1/1255 18/18639 0.0555555555555556 0.825099601593625 0.715009515940512 0.924381515399945 GO:0034185 apolipoprotein binding 1/1255 18/18639 0.0555555555555556 0.825099601593625 0.715009515940512 0.924381515399945 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 1/1255 18/18639 0.0555555555555556 0.825099601593625 0.715009515940512 0.924381515399945 GO:0070628 proteasome binding 1/1255 18/18639 0.0555555555555556 0.825099601593625 0.715009515940512 0.924381515399945 GO:1901611 phosphatidylglycerol binding 1/1255 18/18639 0.0555555555555556 0.825099601593625 0.715009515940512 0.924381515399945 GO:0023023 MHC protein complex binding 2/1255 37/18639 0.0540540540540541 0.802799612361365 0.721877191251854 0.931106815664678 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 7/1255 122/18639 0.0573770491803279 0.852152047547515 0.72187869504531 0.931106815664678 GO:0140767 enzyme-substrate adaptor activity 8/1255 139/18639 0.0575539568345324 0.854779443377569 0.726259663930301 0.931955021366408 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 1/1255 19/18639 0.0526315789473684 0.781673306772908 0.734217026680787 0.931955021366408 GO:0004890 GABA-A receptor activity 1/1255 19/18639 0.0526315789473684 0.781673306772908 0.734217026680787 0.931955021366408 GO:0005346 purine ribonucleotide transmembrane transporter activity 1/1255 19/18639 0.0526315789473684 0.781673306772908 0.734217026680787 0.931955021366408 GO:0005520 insulin-like growth factor binding 1/1255 19/18639 0.0526315789473684 0.781673306772908 0.734217026680787 0.931955021366408 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 1/1255 19/18639 0.0526315789473684 0.781673306772908 0.734217026680787 0.931955021366408 GO:0022821 solute:potassium antiporter activity 1/1255 19/18639 0.0526315789473684 0.781673306772908 0.734217026680787 0.931955021366408 GO:0022840 leak channel activity 1/1255 19/18639 0.0526315789473684 0.781673306772908 0.734217026680787 0.931955021366408 GO:0022842 narrow pore channel activity 1/1255 19/18639 0.0526315789473684 0.781673306772908 0.734217026680787 0.931955021366408 GO:0031420 alkali metal ion binding 1/1255 19/18639 0.0526315789473684 0.781673306772908 0.734217026680787 0.931955021366408 GO:0042834 peptidoglycan binding 1/1255 19/18639 0.0526315789473684 0.781673306772908 0.734217026680787 0.931955021366408 GO:0046527 glucosyltransferase activity 1/1255 19/18639 0.0526315789473684 0.781673306772908 0.734217026680787 0.931955021366408 GO:0070003 threonine-type peptidase activity 1/1255 19/18639 0.0526315789473684 0.781673306772908 0.734217026680787 0.931955021366408 GO:0097001 ceramide binding 1/1255 19/18639 0.0526315789473684 0.781673306772908 0.734217026680787 0.931955021366408 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 2/1255 38/18639 0.0526315789473684 0.781673306772908 0.735526636814505 0.932557608764816 GO:0030170 pyridoxal phosphate binding 3/1255 56/18639 0.0535714285714286 0.795631758679567 0.736820359708275 0.933138709517169 GO:0072341 modified amino acid binding 5/1255 91/18639 0.0549450549450549 0.816032573004685 0.741761229277327 0.938332155269281 GO:0015932 nucleobase-containing compound transmembrane transporter activity 3/1255 57/18639 0.0526315789473684 0.781673306772908 0.747730924787667 0.940671249172332 GO:0070279 vitamin B6 binding 3/1255 57/18639 0.0526315789473684 0.781673306772908 0.747730924787667 0.940671249172332 GO:0004857 enzyme inhibitor activity 25/1255 416/18639 0.0600961538461538 0.892535626723874 0.751847532607374 0.940671249172332 GO:0001614 purinergic nucleotide receptor activity 1/1255 20/18639 0.05 0.742589641434263 0.752130970371207 0.940671249172332 GO:0010851 cyclase regulator activity 1/1255 20/18639 0.05 0.742589641434263 0.752130970371207 0.940671249172332 GO:0016004 phospholipase activator activity 1/1255 20/18639 0.05 0.742589641434263 0.752130970371207 0.940671249172332 GO:0016502 nucleotide receptor activity 1/1255 20/18639 0.05 0.742589641434263 0.752130970371207 0.940671249172332 GO:0042288 MHC class I protein binding 1/1255 20/18639 0.05 0.742589641434263 0.752130970371207 0.940671249172332 GO:0061608 nuclear import signal receptor activity 1/1255 20/18639 0.05 0.742589641434263 0.752130970371207 0.940671249172332 GO:0004519 endonuclease activity 7/1255 127/18639 0.0551181102362205 0.818602754336983 0.759466218113141 0.940671249172332 GO:0004532 RNA exonuclease activity 2/1255 40/18639 0.05 0.742589641434263 0.761114864154276 0.940671249172332 GO:0015036 disulfide oxidoreductase activity 2/1255 40/18639 0.05 0.742589641434263 0.761114864154276 0.940671249172332 GO:0030331 nuclear estrogen receptor binding 2/1255 40/18639 0.05 0.742589641434263 0.761114864154276 0.940671249172332 GO:0061791 GTPase motor activity 2/1255 40/18639 0.05 0.742589641434263 0.761114864154276 0.940671249172332 GO:0071949 FAD binding 2/1255 40/18639 0.05 0.742589641434263 0.761114864154276 0.940671249172332 GO:1990606 membrane scission GTPase motor activity 2/1255 40/18639 0.05 0.742589641434263 0.761114864154276 0.940671249172332 GO:0051536 iron-sulfur cluster binding 4/1255 76/18639 0.0526315789473684 0.781673306772908 0.761456025488601 0.940671249172332 GO:0140098 catalytic activity, acting on RNA 23/1255 387/18639 0.0594315245478036 0.882664690076902 0.762981979752246 0.940671249172332 GO:0004866 endopeptidase inhibitor activity 9/1255 161/18639 0.0559006211180124 0.830224443839549 0.763843739162964 0.940671249172332 GO:0001846 opsonin binding 1/1255 21/18639 0.0476190476190476 0.707228229937393 0.768838399996006 0.940671249172332 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 1/1255 21/18639 0.0476190476190476 0.707228229937393 0.768838399996006 0.940671249172332 GO:0005123 death receptor binding 1/1255 21/18639 0.0476190476190476 0.707228229937393 0.768838399996006 0.940671249172332 GO:0005248 voltage-gated sodium channel activity 1/1255 21/18639 0.0476190476190476 0.707228229937393 0.768838399996006 0.940671249172332 GO:0036122 BMP binding 1/1255 21/18639 0.0476190476190476 0.707228229937393 0.768838399996006 0.940671249172332 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 1/1255 21/18639 0.0476190476190476 0.707228229937393 0.768838399996006 0.940671249172332 GO:0061891 calcium ion sensor activity 1/1255 21/18639 0.0476190476190476 0.707228229937393 0.768838399996006 0.940671249172332 GO:0070182 DNA polymerase binding 1/1255 21/18639 0.0476190476190476 0.707228229937393 0.768838399996006 0.940671249172332 GO:1904047 S-adenosyl-L-methionine binding 1/1255 21/18639 0.0476190476190476 0.707228229937393 0.768838399996006 0.940671249172332 GO:0051540 metal cluster binding 4/1255 77/18639 0.051948051948052 0.771521705386247 0.770376030843306 0.940671249172332 GO:0001530 lipopolysaccharide binding 2/1255 41/18639 0.0487804878048781 0.724477698960257 0.773085234324262 0.940671249172332 GO:0016877 ligase activity, forming carbon-sulfur bonds 2/1255 41/18639 0.0487804878048781 0.724477698960257 0.773085234324262 0.940671249172332 GO:0017080 sodium channel regulator activity 2/1255 41/18639 0.0487804878048781 0.724477698960257 0.773085234324262 0.940671249172332 GO:0061650 ubiquitin-like protein conjugating enzyme activity 2/1255 41/18639 0.0487804878048781 0.724477698960257 0.773085234324262 0.940671249172332 GO:0140318 protein transporter activity 2/1255 41/18639 0.0487804878048781 0.724477698960257 0.773085234324262 0.940671249172332 GO:0140828 metal cation:monoatomic cation antiporter activity 2/1255 41/18639 0.0487804878048781 0.724477698960257 0.773085234324262 0.940671249172332 GO:0003730 mRNA 3'-UTR binding 15/1255 262/18639 0.0572519083969466 0.850293482558316 0.778267254174036 0.944250842786967 GO:0004714 transmembrane receptor protein tyrosine kinase activity 3/1255 60/18639 0.05 0.742589641434263 0.778295615514595 0.944250842786967 GO:0004896 cytokine receptor activity 5/1255 96/18639 0.0520833333333333 0.773530876494024 0.782665704175151 0.944250842786967 GO:0008970 phospholipase A1 activity 1/1255 22/18639 0.0454545454545455 0.675081492212966 0.784420514509112 0.944250842786967 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 1/1255 22/18639 0.0454545454545455 0.675081492212966 0.784420514509112 0.944250842786967 GO:0030021 extracellular matrix structural constituent conferring compression resistance 1/1255 22/18639 0.0454545454545455 0.675081492212966 0.784420514509112 0.944250842786967 GO:0031683 G-protein beta/gamma-subunit complex binding 1/1255 22/18639 0.0454545454545455 0.675081492212966 0.784420514509112 0.944250842786967 GO:0140784 metal ion sensor activity 1/1255 22/18639 0.0454545454545455 0.675081492212966 0.784420514509112 0.944250842786967 GO:0015370 solute:sodium symporter activity 4/1255 79/18639 0.0506329113924051 0.751989510313178 0.787427692687076 0.944250842786967 GO:0005525 GTP binding 22/1255 378/18639 0.0582010582010582 0.86439005881237 0.79109388104089 0.944250842786967 GO:0008509 monoatomic anion transmembrane transporter activity 8/1255 149/18639 0.0536912751677852 0.79741169549988 0.793161156107889 0.944250842786967 GO:0000295 adenine nucleotide transmembrane transporter activity 1/1255 23/18639 0.0434782608695652 0.645730122986315 0.798953052205361 0.944250842786967 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 1/1255 23/18639 0.0434782608695652 0.645730122986315 0.798953052205361 0.944250842786967 GO:0005212 structural constituent of eye lens 1/1255 23/18639 0.0434782608695652 0.645730122986315 0.798953052205361 0.944250842786967 GO:0016493 C-C chemokine receptor activity 1/1255 23/18639 0.0434782608695652 0.645730122986315 0.798953052205361 0.944250842786967 GO:0016917 GABA receptor activity 1/1255 23/18639 0.0434782608695652 0.645730122986315 0.798953052205361 0.944250842786967 GO:0042171 lysophosphatidic acid acyltransferase activity 1/1255 23/18639 0.0434782608695652 0.645730122986315 0.798953052205361 0.944250842786967 GO:0043274 phospholipase binding 1/1255 23/18639 0.0434782608695652 0.645730122986315 0.798953052205361 0.944250842786967 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 1/1255 23/18639 0.0434782608695652 0.645730122986315 0.798953052205361 0.944250842786967 GO:0071617 lysophospholipid acyltransferase activity 1/1255 23/18639 0.0434782608695652 0.645730122986315 0.798953052205361 0.944250842786967 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 1/1255 23/18639 0.0434782608695652 0.645730122986315 0.798953052205361 0.944250842786967 GO:0015294 solute:monoatomic cation symporter activity 6/1255 116/18639 0.0517241379310345 0.768196180794065 0.801202918121439 0.944250842786967 GO:0030971 receptor tyrosine kinase binding 4/1255 81/18639 0.0493827160493827 0.733421868083223 0.803452319331341 0.944250842786967 GO:1901682 sulfur compound transmembrane transporter activity 3/1255 63/18639 0.0476190476190476 0.707228229937393 0.805744699862836 0.944250842786967 GO:0016790 thiolester hydrolase activity 2/1255 44/18639 0.0454545454545455 0.675081492212966 0.805898947905431 0.944250842786967 GO:0015297 antiporter activity 7/1255 135/18639 0.0518518518518519 0.770092961487384 0.811721421518781 0.944250842786967 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 1/1255 24/18639 0.0416666666666667 0.618824701195219 0.812506657678195 0.944250842786967 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 1/1255 24/18639 0.0416666666666667 0.618824701195219 0.812506657678195 0.944250842786967 GO:0004622 lysophospholipase activity 1/1255 24/18639 0.0416666666666667 0.618824701195219 0.812506657678195 0.944250842786967 GO:0005315 phosphate transmembrane transporter activity 1/1255 24/18639 0.0416666666666667 0.618824701195219 0.812506657678195 0.944250842786967 GO:0015295 solute:proton symporter activity 1/1255 24/18639 0.0416666666666667 0.618824701195219 0.812506657678195 0.944250842786967 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 1/1255 24/18639 0.0416666666666667 0.618824701195219 0.812506657678195 0.944250842786967 GO:0019957 C-C chemokine binding 1/1255 24/18639 0.0416666666666667 0.618824701195219 0.812506657678195 0.944250842786967 GO:0042625 ATPase-coupled ion transmembrane transporter activity 1/1255 24/18639 0.0416666666666667 0.618824701195219 0.812506657678195 0.944250842786967 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 1/1255 24/18639 0.0416666666666667 0.618824701195219 0.812506657678195 0.944250842786967 GO:0046961 proton-transporting ATPase activity, rotational mechanism 1/1255 24/18639 0.0416666666666667 0.618824701195219 0.812506657678195 0.944250842786967 GO:0050699 WW domain binding 1/1255 24/18639 0.0416666666666667 0.618824701195219 0.812506657678195 0.944250842786967 GO:0060229 lipase activator activity 1/1255 24/18639 0.0416666666666667 0.618824701195219 0.812506657678195 0.944250842786967 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 1/1255 24/18639 0.0416666666666667 0.618824701195219 0.812506657678195 0.944250842786967 GO:0022853 active monoatomic ion transmembrane transporter activity 6/1255 118/18639 0.0508474576271186 0.755175906543318 0.814085660241555 0.944250842786967 GO:0004536 DNA nuclease activity 3/1255 64/18639 0.046875 0.696177788844622 0.814235254257026 0.944250842786967 GO:0042605 peptide antigen binding 2/1255 45/18639 0.0444444444444444 0.6600796812749 0.815860393932111 0.944250842786967 GO:0051539 4 iron, 4 sulfur cluster binding 2/1255 45/18639 0.0444444444444444 0.6600796812749 0.815860393932111 0.944250842786967 GO:0031406 carboxylic acid binding 10/1255 187/18639 0.053475935828877 0.794213520250549 0.816073097271557 0.944250842786967 GO:0019843 rRNA binding 3/1255 65/18639 0.0461538461538462 0.685467361323935 0.822408952795051 0.944250842786967 GO:0000030 mannosyltransferase activity 1/1255 25/18639 0.04 0.59407171314741 0.825147224136098 0.944250842786967 GO:0004709 MAP kinase kinase kinase activity 1/1255 25/18639 0.04 0.59407171314741 0.825147224136098 0.944250842786967 GO:0005251 delayed rectifier potassium channel activity 1/1255 25/18639 0.04 0.59407171314741 0.825147224136098 0.944250842786967 GO:0005537 D-mannose binding 1/1255 25/18639 0.04 0.59407171314741 0.825147224136098 0.944250842786967 GO:0008139 nuclear localization sequence binding 1/1255 25/18639 0.04 0.59407171314741 0.825147224136098 0.944250842786967 GO:0008483 transaminase activity 1/1255 25/18639 0.04 0.59407171314741 0.825147224136098 0.944250842786967 GO:0015645 fatty acid ligase activity 1/1255 25/18639 0.04 0.59407171314741 0.825147224136098 0.944250842786967 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 1/1255 25/18639 0.04 0.59407171314741 0.825147224136098 0.944250842786967 GO:0017025 TBP-class protein binding 1/1255 25/18639 0.04 0.59407171314741 0.825147224136098 0.944250842786967 GO:0017056 structural constituent of nuclear pore 1/1255 25/18639 0.04 0.59407171314741 0.825147224136098 0.944250842786967 GO:0047617 fatty acyl-CoA hydrolase activity 1/1255 25/18639 0.04 0.59407171314741 0.825147224136098 0.944250842786967 GO:0120515 fatty acid-CoA ligase activity 1/1255 25/18639 0.04 0.59407171314741 0.825147224136098 0.944250842786967 GO:0004527 exonuclease activity 4/1255 84/18639 0.0476190476190476 0.707228229937393 0.825635106187704 0.944250842786967 GO:0043177 organic acid binding 10/1255 189/18639 0.0529100529100529 0.785809144374881 0.825902482903193 0.944250842786967 GO:0015108 chloride transmembrane transporter activity 6/1255 121/18639 0.0495867768595041 0.7364525369596 0.83216736683803 0.950440642901922 GO:0004112 cyclic-nucleotide phosphodiesterase activity 1/1255 26/18639 0.0384615384615385 0.571222801103279 0.836936212731198 0.951025177640639 GO:0008066 glutamate receptor activity 1/1255 26/18639 0.0384615384615385 0.571222801103279 0.836936212731198 0.951025177640639 GO:0015216 purine nucleotide transmembrane transporter activity 1/1255 26/18639 0.0384615384615385 0.571222801103279 0.836936212731198 0.951025177640639 GO:0016289 acyl-CoA hydrolase activity 1/1255 26/18639 0.0384615384615385 0.571222801103279 0.836936212731198 0.951025177640639 GO:0030247 polysaccharide binding 1/1255 26/18639 0.0384615384615385 0.571222801103279 0.836936212731198 0.951025177640639 GO:0004518 nuclease activity 11/1255 209/18639 0.0526315789473684 0.781673306772908 0.839682934924399 0.95317666494975 GO:0140223 general transcription initiation factor activity 3/1255 68/18639 0.0441176470588235 0.655226154206703 0.845108389159642 0.956705930953925 GO:0004683 calcium/calmodulin-dependent protein kinase activity 1/1255 27/18639 0.037037037037037 0.550066401062417 0.847930950442601 0.956705930953925 GO:0005044 scavenger receptor activity 1/1255 27/18639 0.037037037037037 0.550066401062417 0.847930950442601 0.956705930953925 GO:0008320 protein transmembrane transporter activity 1/1255 27/18639 0.037037037037037 0.550066401062417 0.847930950442601 0.956705930953925 GO:0015252 proton channel activity 1/1255 27/18639 0.037037037037037 0.550066401062417 0.847930950442601 0.956705930953925 GO:0023026 MHC class II protein complex binding 1/1255 27/18639 0.037037037037037 0.550066401062417 0.847930950442601 0.956705930953925 GO:0005267 potassium channel activity 6/1255 124/18639 0.0483870967741935 0.718635136871867 0.848811253757346 0.95673276533497 GO:0015079 potassium ion transmembrane transporter activity 8/1255 160/18639 0.05 0.742589641434263 0.851777018021652 0.95910779146188 GO:0001664 G protein-coupled receptor binding 16/1255 297/18639 0.0538720538720539 0.800096583363516 0.854332993140049 0.961017072847366 GO:0046625 sphingolipid binding 1/1255 28/18639 0.0357142857142857 0.530421172453045 0.858184907953591 0.961535157067549 GO:0050698 proteoglycan sulfotransferase activity 1/1255 28/18639 0.0357142857142857 0.530421172453045 0.858184907953591 0.961535157067549 GO:0097718 disordered domain specific binding 1/1255 28/18639 0.0357142857142857 0.530421172453045 0.858184907953591 0.961535157067549 GO:0015605 organophosphate ester transmembrane transporter activity 2/1255 50/18639 0.04 0.59407171314741 0.859097660477542 0.961535157067549 GO:0048020 CCR chemokine receptor binding 2/1255 50/18639 0.04 0.59407171314741 0.859097660477542 0.961535157067549 GO:0016758 hexosyltransferase activity 10/1255 197/18639 0.050761421319797 0.753898113131231 0.861238556120662 0.9629664336204 GO:0019001 guanyl nucleotide binding 22/1255 400/18639 0.055 0.816848605577689 0.865035162264854 0.96527899725259 GO:0032561 guanyl ribonucleotide binding 22/1255 400/18639 0.055 0.816848605577689 0.865035162264854 0.96527899725259 GO:0016757 glycosyltransferase activity 14/1255 267/18639 0.052434456928839 0.778745691391736 0.866861215309681 0.966351274951011 GO:0004181 metallocarboxypeptidase activity 1/1255 29/18639 0.0344827586206897 0.512130787196043 0.867747958865323 0.966375344020504 GO:0015293 symporter activity 7/1255 146/18639 0.0479452054794521 0.712072258909567 0.868675934271851 0.966445237631133 GO:0046982 protein heterodimerization activity 20/1255 369/18639 0.0542005420054201 0.804975221066952 0.871046518727125 0.96757819788708 GO:0042379 chemokine receptor binding 3/1255 72/18639 0.0416666666666667 0.618824701195219 0.871426738652106 0.96757819788708 GO:0005080 protein kinase C binding 2/1255 52/18639 0.0384615384615385 0.571222801103279 0.873629933986282 0.968582211884332 GO:0008106 alcohol dehydrogenase (NADP+) activity 1/1255 30/18639 0.0333333333333333 0.495059760956175 0.876666621499606 0.968582211884332 GO:0016769 transferase activity, transferring nitrogenous groups 1/1255 30/18639 0.0333333333333333 0.495059760956175 0.876666621499606 0.968582211884332 GO:0033612 receptor serine/threonine kinase binding 1/1255 30/18639 0.0333333333333333 0.495059760956175 0.876666621499606 0.968582211884332 GO:0070566 adenylyltransferase activity 1/1255 30/18639 0.0333333333333333 0.495059760956175 0.876666621499606 0.968582211884332 GO:0005544 calcium-dependent phospholipid binding 2/1255 53/18639 0.0377358490566038 0.560445012403217 0.880366464452291 0.969199322545163 GO:0008146 sulfotransferase activity 2/1255 53/18639 0.0377358490566038 0.560445012403217 0.880366464452291 0.969199322545163 GO:1901505 carbohydrate derivative transmembrane transporter activity 2/1255 53/18639 0.0377358490566038 0.560445012403217 0.880366464452291 0.969199322545163 GO:0016874 ligase activity 8/1255 167/18639 0.0479041916167665 0.711463129517857 0.881597452472966 0.969199322545163 GO:0005310 dicarboxylic acid transmembrane transporter activity 1/1255 31/18639 0.032258064516129 0.479090091247912 0.884984284459357 0.969199322545163 GO:0005452 solute:inorganic anion antiporter activity 1/1255 31/18639 0.032258064516129 0.479090091247912 0.884984284459357 0.969199322545163 GO:0016411 acylglycerol O-acyltransferase activity 1/1255 31/18639 0.032258064516129 0.479090091247912 0.884984284459357 0.969199322545163 GO:0072349 modified amino acid transmembrane transporter activity 1/1255 31/18639 0.032258064516129 0.479090091247912 0.884984284459357 0.969199322545163 GO:0005261 monoatomic cation channel activity 18/1255 341/18639 0.0527859237536657 0.783965603860219 0.886235897974672 0.969199322545163 GO:0003925 G protein activity 2/1255 54/18639 0.037037037037037 0.550066401062417 0.886769657691277 0.969199322545163 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 2/1255 54/18639 0.037037037037037 0.550066401062417 0.886769657691277 0.969199322545163 GO:0015106 bicarbonate transmembrane transporter activity 1/1255 32/18639 0.03125 0.464118525896414 0.892741417036931 0.969210606567681 GO:0022884 macromolecule transmembrane transporter activity 1/1255 32/18639 0.03125 0.464118525896414 0.892741417036931 0.969210606567681 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1/1255 32/18639 0.03125 0.464118525896414 0.892741417036931 0.969210606567681 GO:0042910 xenobiotic transmembrane transporter activity 1/1255 32/18639 0.03125 0.464118525896414 0.892741417036931 0.969210606567681 GO:0071813 lipoprotein particle binding 1/1255 32/18639 0.03125 0.464118525896414 0.892741417036931 0.969210606567681 GO:0071814 protein-lipid complex binding 1/1255 32/18639 0.03125 0.464118525896414 0.892741417036931 0.969210606567681 GO:0008374 O-acyltransferase activity 2/1255 55/18639 0.0363636363636364 0.540065193770373 0.892853817509529 0.969210606567681 GO:0005342 organic acid transmembrane transporter activity 9/1255 189/18639 0.0476190476190476 0.707228229937393 0.896417437414395 0.972134250089203 GO:0019239 deaminase activity 1/1255 33/18639 0.0303030303030303 0.450054328141978 0.899975765487442 0.974101676404528 GO:0071889 14-3-3 protein binding 1/1255 33/18639 0.0303030303030303 0.450054328141978 0.899975765487442 0.974101676404528 GO:1990782 protein tyrosine kinase binding 5/1255 117/18639 0.0427350427350427 0.634692001225866 0.901926748646641 0.975268323560791 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 1/1255 34/18639 0.0294117647058824 0.436817436137802 0.906722536115909 0.977614935175165 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 1/1255 34/18639 0.0294117647058824 0.436817436137802 0.906722536115909 0.977614935175165 GO:0016831 carboxy-lyase activity 1/1255 34/18639 0.0294117647058824 0.436817436137802 0.906722536115909 0.977614935175165 GO:0003735 structural constituent of ribosome 8/1255 175/18639 0.0457142857142857 0.678939100739898 0.909419356311652 0.978633353564658 GO:0022832 voltage-gated channel activity 8/1255 175/18639 0.0457142857142857 0.678939100739898 0.909419356311652 0.978633353564658 GO:0008236 serine-type peptidase activity 9/1255 194/18639 0.0463917525773196 0.689000698237976 0.911912585634993 0.979551468457997 GO:0004252 serine-type endopeptidase activity 8/1255 176/18639 0.0454545454545455 0.675081492212966 0.912471806911366 0.979551468457997 GO:0016229 steroid dehydrogenase activity 1/1255 35/18639 0.0285714285714286 0.424336937962436 0.913014566063479 0.979551468457997 GO:0022836 gated channel activity 16/1255 318/18639 0.050314465408805 0.747260016537623 0.913780331363682 0.979551468457997 GO:0004033 aldo-keto reductase (NADPH) activity 1/1255 36/18639 0.0277777777777778 0.412549800796813 0.918882482618539 0.981874979909926 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 2/1255 60/18639 0.0333333333333333 0.495059760956175 0.918960388304097 0.981874979909926 GO:0008528 G protein-coupled peptide receptor activity 5/1255 122/18639 0.040983606557377 0.608680033962511 0.920045146488153 0.981874979909926 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 5/1255 122/18639 0.040983606557377 0.608680033962511 0.920045146488153 0.981874979909926 GO:0005253 monoatomic anion channel activity 4/1255 103/18639 0.0388349514563107 0.576768653541175 0.922581540916625 0.981874979909926 GO:0017171 serine hydrolase activity 9/1255 198/18639 0.0454545454545455 0.675081492212966 0.92285075692057 0.981874979909926 GO:0005254 chloride channel activity 3/1255 83/18639 0.036144578313253 0.536811788988624 0.924495851789937 0.981874979909926 GO:0022843 voltage-gated monoatomic cation channel activity 6/1255 143/18639 0.041958041958042 0.623152146658123 0.925395163133931 0.981874979909926 GO:0016829 lyase activity 9/1255 200/18639 0.045 0.668330677290837 0.92786865508176 0.981874979909926 GO:0004860 protein kinase inhibitor activity 3/1255 84/18639 0.0357142857142857 0.530421172453045 0.928157360886316 0.981874979909926 GO:0005109 frizzled binding 1/1255 38/18639 0.0263157894736842 0.390836653386454 0.929458317093673 0.981874979909926 GO:0015081 sodium ion transmembrane transporter activity 7/1255 164/18639 0.0426829268292683 0.633917986590224 0.930862880360258 0.981874979909926 GO:0005507 copper ion binding 2/1255 63/18639 0.0317460317460317 0.471485486624929 0.931619032206397 0.981874979909926 GO:0022824 transmitter-gated monoatomic ion channel activity 2/1255 63/18639 0.0317460317460317 0.471485486624929 0.931619032206397 0.981874979909926 GO:0022835 transmitter-gated channel activity 2/1255 63/18639 0.0317460317460317 0.471485486624929 0.931619032206397 0.981874979909926 GO:0015103 inorganic anion transmembrane transporter activity 7/1255 165/18639 0.0424242424242424 0.630076059398769 0.933398565876981 0.981874979909926 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 1/1255 39/18639 0.0256410256410256 0.380815200735519 0.934217728525717 0.981874979909926 GO:0050660 flavin adenine dinucleotide binding 3/1255 86/18639 0.0348837209302326 0.518085796349486 0.934995389504262 0.981874979909926 GO:0015399 primary active transmembrane transporter activity 7/1255 166/18639 0.0421686746987952 0.626280420486728 0.935852176896965 0.981874979909926 GO:0046873 metal ion transmembrane transporter activity 23/1255 450/18639 0.0511111111111111 0.759091633466136 0.936053946271999 0.981874979909926 GO:0001653 peptide receptor activity 5/1255 128/18639 0.0390625 0.580148157370518 0.93783258358089 0.981874979909926 GO:0015144 carbohydrate transmembrane transporter activity 1/1255 40/18639 0.025 0.371294820717131 0.9386562635096 0.981874979909926 GO:0071855 neuropeptide receptor binding 1/1255 40/18639 0.025 0.371294820717131 0.9386562635096 0.981874979909926 GO:0140662 ATP-dependent protein folding chaperone 1/1255 40/18639 0.025 0.371294820717131 0.9386562635096 0.981874979909926 GO:0004620 phospholipase activity 4/1255 109/18639 0.036697247706422 0.545019920318725 0.941073229383042 0.981874979909926 GO:0046943 carboxylic acid transmembrane transporter activity 8/1255 188/18639 0.0425531914893617 0.631991184199373 0.942743449458948 0.981874979909926 GO:0008227 G protein-coupled amine receptor activity 1/1255 41/18639 0.024390243902439 0.362238849480128 0.942795539239233 0.981874979909926 GO:0042287 MHC protein binding 1/1255 41/18639 0.024390243902439 0.362238849480128 0.942795539239233 0.981874979909926 GO:0016298 lipase activity 5/1255 130/18639 0.0384615384615385 0.571222801103279 0.94291996542077 0.981874979909926 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 5/1255 130/18639 0.0384615384615385 0.571222801103279 0.94291996542077 0.981874979909926 GO:0030246 carbohydrate binding 13/1255 280/18639 0.0464285714285714 0.689547524188958 0.94319772018205 0.981874979909926 GO:0008307 structural constituent of muscle 1/1255 42/18639 0.0238095238095238 0.353614114968697 0.946655717659212 0.981912157988968 GO:0042056 chemoattractant activity 1/1255 42/18639 0.0238095238095238 0.353614114968697 0.946655717659212 0.981912157988968 GO:0019210 kinase inhibitor activity 3/1255 90/18639 0.0333333333333333 0.495059760956175 0.946903273506615 0.981912157988968 GO:0005179 hormone activity 5/1255 132/18639 0.0378787878787879 0.562567910177472 0.947628743341188 0.981912157988968 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 5/1255 132/18639 0.0378787878787879 0.562567910177472 0.947628743341188 0.981912157988968 GO:0005548 phospholipid transporter activity 2/1255 68/18639 0.0294117647058824 0.436817436137802 0.948652703819076 0.982062159560619 GO:0005244 voltage-gated monoatomic ion channel activity 7/1255 173/18639 0.0404624277456647 0.600939594224259 0.950902986705964 0.983480218657928 GO:0015291 secondary active transmembrane transporter activity 13/1255 287/18639 0.0452961672473868 0.672729291891667 0.954218360288983 0.984220786606908 GO:0008028 monocarboxylic acid transmembrane transporter activity 2/1255 70/18639 0.0285714285714286 0.424336937962436 0.954262409933108 0.984220786606908 GO:0016782 transferase activity, transferring sulphur-containing groups 2/1255 70/18639 0.0285714285714286 0.424336937962436 0.954262409933108 0.984220786606908 GO:0140375 immune receptor activity 6/1255 156/18639 0.0384615384615385 0.571222801103279 0.955763632361255 0.984859757700666 GO:0005319 lipid transporter activity 7/1255 178/18639 0.0393258426966292 0.584059268543802 0.959632623763282 0.987043107678924 GO:0004180 carboxypeptidase activity 1/1255 46/18639 0.0217391304347826 0.322865061493158 0.959663064678012 0.987043107678924 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 2/1255 73/18639 0.0273972602739726 0.40689843366261 0.9615908716669 0.987043107678924 GO:0043495 protein-membrane adaptor activity 1/1255 47/18639 0.0212765957446809 0.315995592099686 0.962385748151851 0.987043107678924 GO:0140359 ABC-type transporter activity 1/1255 47/18639 0.0212765957446809 0.315995592099686 0.962385748151851 0.987043107678924 GO:0005249 voltage-gated potassium channel activity 3/1255 98/18639 0.0306122448979592 0.454646719245467 0.96487367622326 0.987043107678924 GO:0038187 pattern recognition receptor activity 1/1255 48/18639 0.0208333333333333 0.30941235059761 0.964924791077272 0.987043107678924 GO:0022804 active transmembrane transporter activity 22/1255 457/18639 0.0481400437636762 0.71496595674196 0.965330486908929 0.987043107678924 GO:0044183 protein folding chaperone 2/1255 75/18639 0.0266666666666667 0.39604780876494 0.965835377522886 0.987043107678924 GO:0032813 tumor necrosis factor receptor superfamily binding 1/1255 50/18639 0.02 0.297035856573705 0.969500629885474 0.989883184261494 GO:0016830 carbon-carbon lyase activity 1/1255 51/18639 0.0196078431372549 0.291211624091868 0.971559735243144 0.991079656864468 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 1/1255 52/18639 0.0192307692307692 0.28561140055164 0.973479927424651 0.991853688444551 GO:0016251 RNA polymerase II general transcription initiation factor activity 1/1255 53/18639 0.0188679245283019 0.280222506201609 0.97527057094335 0.991853688444551 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 1/1255 53/18639 0.0188679245283019 0.280222506201609 0.97527057094335 0.991853688444551 GO:0008514 organic anion transmembrane transporter activity 11/1255 269/18639 0.0408921933085502 0.607322383329137 0.975870370278032 0.991853688444551 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 1/1255 54/18639 0.0185185185185185 0.275033200531208 0.976940399495276 0.992038569305658 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 1/1255 56/18639 0.0178571428571429 0.265210586226522 0.979949644311044 0.99419051107669 GO:0005216 monoatomic ion channel activity 20/1255 448/18639 0.0446428571428571 0.663026465566306 0.983650929509269 0.997040007497145 GO:0052689 carboxylic ester hydrolase activity 2/1255 92/18639 0.0217391304347826 0.322865061493158 0.987611966833419 0.999980813611406 GO:0160215 deacylase activity 1/1255 65/18639 0.0153846153846154 0.228489120441312 0.989315489293109 0.999980813611406 GO:0008173 RNA methyltransferase activity 1/1255 67/18639 0.0149253731343284 0.22166854968187 0.990710599523928 0.999980813611406 GO:0030594 neurotransmitter receptor activity 2/1255 97/18639 0.0206185567010309 0.306222532550212 0.990858635296051 0.999980813611406 GO:0042626 ATPase-coupled transmembrane transporter activity 2/1255 98/18639 0.0204081632653061 0.303097812830311 0.991399988610067 0.999980813611406 GO:0098960 postsynaptic neurotransmitter receptor activity 1/1255 69/18639 0.0144927536231884 0.215243374328772 0.99192367187237 0.999980813611406 GO:0004497 monooxygenase activity 2/1255 106/18639 0.0188679245283019 0.280222506201609 0.994738109840939 0.999998523292741 GO:0000049 tRNA binding 1/1255 80/18639 0.0125 0.185647410358566 0.996260296228658 0.999998523292741 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 1/1255 91/18639 0.010989010989011 0.163206514600937 0.998269167256682 0.999998523292741 GO:0016798 hydrolase activity, acting on glycosyl bonds 2/1255 130/18639 0.0153846153846154 0.228489120441312 0.998825955219158 0.999998523292741 GO:0005125 cytokine activity 5/1255 234/18639 0.0213675213675214 0.317346000612933 0.999669435135346 0.999998523292741 GO:0003823 antigen binding 2/1255 174/18639 0.0114942528735632 0.170710262398681 0.999930278144114 0.999998523292741 GO:0140101 catalytic activity, acting on a tRNA 1/1255 139/18639 0.00719424460431655 0.106847430422196 0.999940316931996 0.999998523292741 GO:0045182 translation regulator activity 7/1255 356/18639 0.0196629213483146 0.292029634271901 0.999992814947415 0.999998523292741 GO:0030371 translation repressor activity 5/1255 329/18639 0.0151975683890578 0.225711137214062 0.999998523292741 0.999998523292741