category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	98/608	222/9376	6.80749170222854	RPS26/RPL19/RPL14/RPL13/RPL27A/RPL35/RPL30/RPS8/RPS24/RPL10/RPL32/RPLP2/RPL23A/RPS13/RPL28/FAU/RPL41/RPL35A/RPL13A/RPL37/RPS25/RPL34/RPS16/RPL8/RPS14/RPS15/RPS19/RPL24/RPS7/RPL36/RPL3/RPL18A/RPS12/RPS3/RPLP1/RPL12/RPL31/RPS6/RPS15A/RPL38/RPLP0/RACK1/UBA52/RPS2/RPS18/RPS27/RPS23/RPL7A/RPL4/RPL18/RPS28/RPL29/RPL37A/RPL27/RPL11/RPL10A/RPS4X/RPS9/RPS5/RPL22/RPL22L1/RPL36A/RPL6/RPS27A/RPS20/RPSA/RPL5/RPS21/RPL26/MRPL51/RPL21/RPL9/MRPS21/RPS10/MRPL40/RPS3A/RPL15/MRPL17/RPL7/RPS17/MRPL20/RPL17/MRPL12/MRPS34/RPL36AL/RPS29/MRPS26/MRPL36/MRPS2/MRPL52/MRPS12/MRPL21/MRPS15/MRPS6/MRPL55/MRPL54/MRPL23/MRPL37	23.0593355162036
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	83/608	238/9376	5.37793011941619	RPS26/RPL19/RPL14/RPL13/RPL27A/RPL35/RPL30/RPS8/RPS24/RPL10/RPL32/RPLP2/RPL23A/RPS13/RPL28/FAU/RPL41/RPL35A/RPL13A/RPL37/RPS25/RPL34/RPS16/RPL8/RPS14/RPS15/RPS19/RPL24/RPS7/RPL36/RPL3/RPL18A/RPS12/RPS3/RPLP1/RPL12/RPL31/RPS6/RPS15A/RPL38/RPLP0/UBA52/RPS2/RPS18/RPS27/RPS23/RPL7A/RPL4/RPL18/RPS28/RPL29/RPL37A/RPL27/RPL11/RPL10A/RPS4X/RPS9/RPS5/RPL22/RPL22L1/RPL36A/RPL6/RPS27A/RPS20/RPSA/RPL5/RPS21/RPL26/RPL21/RPL9/RPS10/RPS3A/F13A1/RPL15/RPL7/RPS17/RPL17/RPL36AL/PRKCA/RPS29/VWF/C1QA/PIK3R2	18.0143619307403
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	72/608	268/9376	4.14296936370778	MT-CO2/TXN/NDUFS5/COX5B/UQCRH/UBA52/COX7C/COX4I1/NDUFA4/COX6B1/UQCR10/NDUFB7/RPS27A/COX6C/NDUFC2/SLC39A6/NDUFB10/NDUFA13/COX7A1/UQCRQ/CALM1/NDUFA2/COX7B/PSMA7/NDUFB3/COX8A/NDUFA1/SEM1/UQCR11/GNAI2/NDUFB1/MT-ATP8/NDUFB2/COX6A1/PSMB3/GNAS/TXN2/PARK7/NDUFS3/PSMA4/NDUFB8/NDUFS6/SLC25A6/TUBA1B/CYC1/COX7A2/PSMB4/NDUFB4/NDUFA11/PSMB1/CALM3/NDUFAB1/VDAC1/CYCS/COX5A/NDUFA6/NDUFA12/NDUFA3/UQCRB/SLC25A5/PSMC3/BAX/MAP3K5/NDUFB11/NDUFS8/NDUFV2/VDAC2/NDUFA7/NDUFB6/UQCRFS1/PRKACA/NDUFS7	13.7462168596034
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	77/608	308/9376	3.85526315789474	POLR2J3/MT-CO2/NDUFS5/TGM2/COX5B/POLR2L/UQCRH/COX7C/COX4I1/NDUFA4/COX6B1/UQCR10/NDUFB7/COX6C/NDUFC2/CREB3L1/NDUFB10/NDUFA13/COX7A1/UQCRQ/NDUFA2/COX7B/PSMA7/NDUFB3/POLR2F/COX8A/NDUFA1/SEM1/UQCR11/NDUFB1/POLR2I/MT-ATP8/NDUFB2/COX6A1/PSMB3/AP2M1/NDUFS3/PSMA4/NDUFB8/NDUFS6/SLC25A6/TUBA1B/CYC1/COX7A2/PSMB4/NDUFB4/AP2S1/NDUFA11/PSMB1/NDUFAB1/POLR2E/VDAC1/AP2A1/CYCS/GPX1/COX5A/NDUFA6/NDUFA12/NDUFA3/GPX7/UQCRB/GRIA2/SLC25A5/PSMC3/POLR2G/BAX/MAP3K5/NDUFB11/NDUFS8/GRIA4/NDUFV2/POLR2J2/VDAC2/NDUFA7/NDUFB6/UQCRFS1/NDUFS7	13.4169221967514
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	48/608	138/9376	5.36384439359268	MT-CO2/NDUFS5/COX5B/UQCRH/COX7C/COX4I1/NDUFA4/COX6B1/UQCR10/NDUFB7/COX6C/NDUFC2/NDUFB10/NDUFA13/COX7A1/UQCRQ/NDUFA2/COX7B/NDUFB3/COX8A/NDUFA1/UQCR11/NDUFB1/MT-ATP8/NDUFB2/COX6A1/NDUFS3/NDUFB8/NDUFS6/CYC1/COX7A2/NDUFB4/NDUFA11/NDUFAB1/CYCS/COX5A/NDUFA6/NDUFA12/NDUFA3/UQCRB/TCIRG1/NDUFB11/NDUFS8/NDUFV2/NDUFA7/NDUFB6/UQCRFS1/NDUFS7	13.5990001192608
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	58/608	205/9376	4.36302952503209	GAPDH/MT-CO2/NDUFS5/COX5B/UQCRH/COX7C/COX4I1/NDUFA4/COX6B1/UQCR10/NDUFB7/COX6C/NDUFC2/NDUFB10/NDUFA13/COX7A1/UQCRQ/NDUFA2/COX7B/NDUFB3/COX8A/NDUFA1/UQCR11/NDUFB1/MT-ATP8/NDUFB2/COX6A1/NDUFS3/NDUFB8/NDUFS6/COL1A1/SLC25A6/CYBA/CYC1/COX7A2/NDUFB4/SLC2A1/PRKCA/NDUFA11/NDUFAB1/PTEN/VDAC1/COX5A/NDUFA6/NDUFA12/NDUFA3/UQCRB/SLC25A5/CTSD/NDUFB11/NDUFS8/NDUFV2/VDAC2/NDUFA7/NDUFB6/UQCRFS1/NDUFS7/PIK3R2	12.8199526519622
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	67/608	275/9376	3.75712918660287	CACNA1D/MT-CO2/NDUFS5/COX5B/UQCRH/COX7C/COX4I1/NDUFA4/COX6B1/UQCR10/NDUFB7/COX6C/NDUFC2/CREB3L1/NDUFB10/NDUFA13/COX7A1/UQCRQ/NDUFA2/COX7B/PSMA7/NDUFB3/COX8A/NDUFA1/SEM1/UQCR11/NDUFB1/MT-ATP8/NDUFB2/COX6A1/PSMB3/NDUFS3/PSMA4/NDUFB8/NDUFS6/SLC25A6/TUBA1B/CYBA/CYC1/COX7A2/PSMB4/NDUFB4/NDUFA11/PSMB1/NDUFAB1/VDAC1/CYCS/COX5A/NDUFA6/NDUFA12/NDUFA3/NOTCH1/UQCRB/SLC25A5/PSMC3/BAX/NDUFB11/NDUFS8/NDUFV2/VDAC2/NDUFA7/C1QA/NDUFB6/UQCRFS1/PRKACA/NDUFS7/PIK3R2	12.219855282158
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	49/608	157/9376	4.81293999329534	MT-CO2/NDUFS5/COX5B/UQCRH/COX7C/COX4I1/NDUFA4/COX6B1/UQCR10/NDUFB7/COX6C/NDUFC2/NDUFB10/NDUFA13/COX7A1/UQCRQ/NDUFA2/COX7B/NDUFB3/COX8A/NDUFA1/UQCR11/NDUFB1/NDUFB2/COX6A1/NDUFS3/NDUFB8/NDUFS6/CYC1/COX7A2/NDUFB4/NDUFA11/NDUFAB1/CYCS/COX5A/NDUFA6/NDUFA12/NDUFA3/UQCRB/BAX/MAP3K5/NDUFB11/NDUFS8/NDUFV2/NDUFA7/NDUFB6/UQCRFS1/NDUFS7/PIK3R2	12.6868862650676
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	59/608	227/9376	4.00811500115929	MT-CO2/NDUFS5/COX5B/UQCRH/COX7C/COX4I1/NDUFA4/COX6B1/UQCR10/NDUFB7/COX6C/NDUFC2/NDUFB10/NDUFA13/COX7A1/UQCRQ/NDUFA2/COX7B/NDUFB3/COX8A/NDUFA1/UQCR11/NDUFB1/MT-ATP8/NDUFB2/COX6A1/GSTM5/NDUFS3/NDUFB8/NDUFS6/SLC25A6/CYBA/CYC1/COX7A2/NDUFB4/NDUFA11/NDUFAB1/PTEN/VDAC1/COX5A/NDUFA6/NDUFA12/NDUFA3/CBR1/UQCRB/SLC25A5/EPHX2/MAP3K5/NDUFB11/NDUFS8/MGST1/NDUFV2/VDAC2/NDUFA7/NDUFB6/UQCRFS1/NDUFS7/CYP1B1/PIK3R2	12.0811341698805
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	60/608	235/9376	3.93729003359462	MT-CO2/NDUFS5/RPS6/COX5B/UQCRH/COX7C/COX4I1/NDUFA4/COX6B1/UQCR10/NDUFB7/COX6C/NDUFC2/CREB3L1/NDUFB10/NDUFA13/COX7A1/UQCRQ/NDUFA2/COX7B/NDUFB3/COX8A/NDUFA1/UQCR11/NDUFB1/MT-ATP8/NDUFB2/COX6A1/GNAS/NDUFS3/NDUFB8/NDUFS6/CYC1/COX7A2/NDUFB4/NDUFA11/NDUFAB1/SMARCD3/NDUFAF2/COX5A/NDUFA6/NDUFA12/NDUFA3/ADCY3/ACSL5/NDUFAF3/UQCRB/COX14/MAP3K5/NDUFB11/NDUFAF8/NDUFS8/COA6/NDUFV2/NDUFA7/MLST8/NDUFB6/UQCRFS1/PRKACA/NDUFS7	12.008010683677
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	72/608	368/9376	3.01716247139588	MT-CO2/CHCHD10/NDUFS5/COX5B/UQCRH/COX7C/COX4I1/NDUFA4/COX6B1/UQCR10/NDUFB7/NRG2/COX6C/NDUFC2/NDUFB10/NDUFA13/COX7A1/UQCRQ/NDUFA2/COX7B/FUS/PSMA7/NDUFB3/COX8A/PFN1/NDUFA1/SEM1/UQCR11/NDUFB1/MT-ATP8/HNRNPA1/NDUFB2/COX6A1/PSMB3/NDUFS3/PSMA4/NDUFB8/NDUFS6/TUBA1B/CYC1/COX7A2/PSMB4/NDUFB4/NDUFA11/PSMB1/NDUFAB1/VDAC1/CYCS/GPX1/COX5A/NDUFA6/NDUFA12/NDUFA3/SRSF3/GPX7/UQCRB/GRIA2/PSMC3/BCL2/BAX/MAP3K5/TOMM40/NDUFB11/NDUFS8/SEC13/NDUFV2/NDUFA7/MAP2K6/NDUFB6/UQCRFS1/SIGMAR1/NDUFS7	10.3953174799524
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	72/608	388/9376	2.86163863266413	GAPDH/CACNA1D/MT-CO2/APOE/NDUFS5/WNT4/COX5B/UQCRH/COX7C/COX4I1/NDUFA4/COX6B1/UQCR10/NDUFB7/COX6C/NDUFC2/SLC39A6/NDUFB10/NDUFA13/COX7A1/UQCRQ/CALM1/NDUFA2/COX7B/PSMA7/NDUFB3/COX8A/BACE2/NDUFA1/SEM1/UQCR11/NDUFB1/MT-ATP8/NDUFB2/COX6A1/PSMB3/NDUFS3/PSMA4/NDUFB8/NDUFS6/SLC25A6/TUBA1B/CYC1/COX7A2/PSMB4/NDUFB4/NDUFA11/PSMB1/CALM3/NDUFAB1/VDAC1/CYCS/COX5A/NDUFA6/NDUFA12/NDUFA3/UQCRB/FZD4/FZD7/SLC25A5/PSMC3/MAP3K5/NDUFB11/NDUFS8/NDUFV2/VDAC2/NDUFA7/PSENEN/NDUFB6/UQCRFS1/NDUFS7/PIK3R2	9.86204252852892
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	80/608	480/9376	2.57017543859649	CACNA1D/MT-CO2/NDUFS5/WNT4/COX5B/UQCRH/UBA52/COX7C/COX4I1/NDUFA4/COX6B1/UQCR10/NDUFB7/RPS27A/COX6C/NDUFC2/NDUFB10/NDUFA13/COX7A1/UQCRQ/CALM1/NDUFA2/COX7B/FUS/PSMA7/NDUFB3/COX8A/NDUFA1/SEM1/UQCR11/NDUFB1/MT-ATP8/NDUFB2/COX6A1/PSMB3/PARK7/NDUFS3/PSMA4/NDUFB8/NDUFS6/SLC25A6/TUBA1B/CYC1/COX7A2/PSMB4/NDUFB4/PRKCA/NDUFA11/PSMB1/CALM3/NDUFAB1/VDAC1/CYCS/GPX1/COX5A/NDUFA6/NDUFA12/NDUFA3/GPX7/UQCRB/FZD4/FZD7/GRIA2/SLC25A5/PSMC3/BCL2/BAX/MAP3K5/TOMM40/NDUFB11/NDUFS8/GRIA4/NDUFV2/VDAC2/NDUFA7/MAP2K6/NDUFB6/UQCRFS1/SIGMAR1/NDUFS7	9.299477938706
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	35/608	149/9376	3.62239491345814	CACNA1D/NDUFS5/NDUFA4/NDUFB7/NDUFC2/NDUFB10/NDUFA13/NDUFA2/NDUFB3/NDUFA1/GNAI2/NDUFB1/NDUFB2/NDUFS3/NDUFB8/NDUFS6/NDUFB4/PRKCA/NDUFA11/NDUFAB1/NDUFA6/NDUFA12/NDUFA3/ADCY3/GRIA2/NDUFB11/NDUFS8/GNAO1/GRIA4/NDUFV2/NDUFA7/NDUFB6/PRKACA/GABRP/NDUFS7	8.49665775049166
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	23/608	87/9376	4.07683000604961	CACNA1D/MT-CO2/TPM2/COX5B/UQCRH/COX7C/COX4I1/COX6B1/UQCR10/COX6C/COX7A1/UQCRQ/COX7B/COX8A/UQCR11/COX6A1/CYC1/COX7A2/SLC8A1/COX5A/UQCRB/UQCRFS1/ATP1A2	7.59216790877171
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	13/608	46/9376	4.35812356979405	PSMA7/POMP/SEM1/PSME2/PSMB3/PSMB9/PSME1/PSMA4/PSMB4/PSMB1/PSMB8/PSMC3/PSMF1	6.01204086880275
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	10/608	31/9376	4.97453310696095	SEC61A1/SEC11A/SPCS1/SEC62/SEC61B/SEC61G/SRP14/SRPRB/TMEM208/SRPRA	5.83666100694658
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	12/608	53/9376	3.49155908639523	ATP2B1/GNAS/AP2M1/ATP2B4/PRKCA/AP2S1/SLC8A1/AP2A1/DNM1/PRKACA/ATP1A2/BDKRB2	4.78981170238849
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	11/608	51/9376	3.32610939112487	SEC61A1/KDELR2/SEC61B/GNAS/SEC61G/PRKCA/KDELR1/ADCY3/TCIRG1/KDELR3/PRKACA	4.38609425013464
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	27/608	233/9376	1.78698893155636	MYL9/TPM2/COL5A1/DCN/FBLN2/PDLIM2/FBLN1/ITGA6/THBS2/DAAM2/PDLIM1/ENO1/HSPG2/COL1A1/LAMA2/BGN/AMPD2/FLNC/FHL2/DAAM1/CSRP1/SSPN/COL6A3/PDLIM7/ITGA1/ATP1A2/CAPZB	3.20323928624164
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	21/608	166/9376	1.95085605580216	CACNA1D/MYL9/KCNMB1/CREB3L1/ADRA2C/CALM1/ATP2B1/GNAI2/SLC25A6/GUCY1A2/ATP2B4/CALM3/SLC8A1/EDNRA/VDAC1/ADCY3/ADRA2A/SLC25A5/VDAC2/ATP1A2/BDKRB2	3.25481390696908
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	24/608	203/9376	1.82317863624579	MYL9/PDGFRB/IGF1/CCND1/ITGA6/THBS2/LAMC3/LAMB2/COL1A1/LAMA2/MYL12B/PRKCA/FLNA/PGF/PTEN/BCL2/VWF/PDGFD/COL6A3/EMP1/ELK1/ITGA1/PIP5K1B/PIK3R2	3.12229238774161
NA	NA	hsa04518	Integrin signaling	19/608	154/9376	1.9025974025974	FREM1/PDGFRB/IGF1/CCND1/ITGA6/THBS2/LAMC3/LAMB2/FERMT1/COL1A1/LAMA2/FLNA/PGF/VWF/ICAM3/PDGFD/COL6A3/ITGA1/PIK3R2	2.97391833303247
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	7/608	34/9376	3.17492260061919	POLR2J3/POLR2L/POLR2F/POLR2I/POLR2E/POLR2G/POLR2J2	3.34541878004112
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	18/608	144/9376	1.92763157894737	PSMA7/SEM1/PSMB3/PSMA4/NOP56/SLC25A6/PSMB4/PRKCA/PSMB1/KCND3/VDAC1/CYCS/GRIA2/SLC25A5/PSMC3/MAP3K5/VDAC2/PIK3R2	2.95390164125163
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	17/608	134/9376	1.95640219952867	CACNA1D/RAMP1/MYL9/CALD1/KCNMB1/ACTA2/CALM1/EDN3/GNAS/MYL6/GUCY1A2/PRKCA/CALM3/EDNRA/ADCY3/MYL6B/PRKACA	2.93627779313895
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	20/608	174/9376	1.77253478523896	SEC61A1/RRBP1/DAD1/SSR4/SEC62/TMEM258/SEC61B/BCAP31/MAN1B1/SEC61G/SSR1/P4HB/STUB1/BCL2/BAX/MAP3K5/SEC13/TXNDC5/GANAB/SSR2	2.70856155990399
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	13/608	97/9376	2.06673901247965	CACNA1D/CALM1/GNAI2/GNAS/GUCY1A2/PRKCA/CALM3/ADCY3/CACNA1H/GRIA2/GNAO1/GRIA4/PRKACA	2.78086954125819
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	13/608	98/9376	2.04564983888292	CACNA1D/CREB3L1/CALM1/ATP2B1/GNAS/ATP2B4/PRKCA/CALM3/ADCY3/CACNA1H/PRKACA/KCNK3/ATP1A2	2.74005503516011
Organismal Systems	Digestive system	hsa04978	Mineral absorption	9/608	61/9376	2.27523727351165	ATP2B1/MT2A/MT1X/MT1E/ATP2B4/SLC8A1/MT1F/MT1G/ATP1A2	2.63118656684523
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	9/608	62/9376	2.23853989813243	NCOR2/LFNG/HEYL/NOTCH1/TLE1/RFNG/PSENEN/TLE2/DTX1	2.57646879383995
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	9/608	63/9376	2.20300751879699	POLR2J3/POLR2L/CETN2/POLR2F/POLR2I/POLR2E/POLR2G/POLR2J2/ERCC1	2.52278925276407
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	3/608	10/9376	4.62631578947368	TST/SELENBP1/MPST	3.02117374235066
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	21/608	204/9376	1.5874613003096	IGF2/LUM/RPS6/WNT4/DCN/IGF1/CCND1/HOXD10/TIMP3/HSPG2/CD63/CTSL/COL1A1/PRKCA/FLNA/PLCE1/FZD4/FZD7/ELK1/PRKACA/PIK3R2	2.23382671343721
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	12/608	99/9376	1.86921850079745	ASIC2/IGF1/HTR2B/CALM1/GNAS/PRKCA/CALM3/ADCY3/MAP2K6/PRKACA/BDKRB2/PIK3R2	2.28944353925533
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	31/608	333/9376	1.43559348822507	HLA-B/WNT4/PDGFRB/PKM/CCND1/ITGA6/CREB3L1/THBS2/LAMC3/LAMB2/HLA-A/GNAS/BCAP31/LFNG/HEYL/COL1A1/LAMA2/LLGL1/PTEN/NOTCH1/TCIRG1/FZD4/FZD7/BAX/VWF/CHD4/RFNG/COL6A3/ITGA1/PRKACA/PIK3R2	2.13124995602261
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	11/608	89/9376	1.90597279716144	FREM1/ITGA6/THBS2/LAMC3/LAMB2/HSPG2/COL1A1/LAMA2/VWF/COL6A3/ITGA1	2.26130735611516
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	11/608	89/9376	1.90597279716144	PDGFRB/HTR2B/GNAI2/GNAS/GJA1/TUBA1B/GUCY1A2/PRKCA/ADCY3/PDGFD/PRKACA	2.26130735611516
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	12/608	101/9376	1.83220427305888	WNT4/CREB3L1/CALM1/GNAI2/GNAS/PRKCA/CALM3/ADCY3/FZD4/FZD7/GNAO1/PRKACA	2.21422029158725
Organismal Systems	Endocrine system	hsa04924	Renin secretion	9/608	69/9376	2.01144164759725	CACNA1D/CALM1/GNAI2/EDN3/GNAS/GUCY1A2/CALM3/EDNRA/PRKACA	2.22048415289508
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	9/608	69/9376	2.01144164759725	CACNA1D/CREB3L1/CALM1/GNAS/PRKCA/CALM3/GRIA2/GRIA4/PRKACA	2.22048415289508
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	10/608	80/9376	1.92763157894737	RPS6/PDGFRB/IGF1/NRG2/PRKCA/PTEN/BCL2/BAX/PDGFD/PIK3R2	2.19411616940429
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	15/608	139/9376	1.66414237031427	KRT19/CREB3L1/CALM1/KRT10/GNAI2/GNAS/CALM3/KRT17/ADCY3/FKBP5/BCL2/CTSD/GNAO1/PRKACA/PIK3R2	2.07725720214894
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	8/608	59/9376	2.09099018733274	GSTP1/SRM/GPX4/GSTM5/GPX1/PRDX6/GPX7/MGST1	2.21358375923182
Organismal Systems	Digestive system	hsa04970	Salivary secretion	11/608	93/9376	1.82399547255235	CALM1/ATP2B1/CST3/GNAS/GUCY1A2/ATP2B4/PRKCA/CALM3/ADCY3/PRKACA/ATP1A2	2.1028547789877
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	24/608	254/9376	1.4571073352673	CACNA1D/PDGFRB/HTR2B/CALM1/ATP2B1/GNAS/F2R/SLC25A6/ATP2B4/PRKCA/CALM3/SLC8A1/PLCE1/EDNRA/VDAC1/ADCY3/CACNA1H/SLC25A5/ORAI2/FGF1/VDAC2/PDGFD/PRKACA/BDKRB2	1.94480996963557
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	15/608	142/9376	1.62898443291327	TXN/GSTP1/ASS1/CALM1/SUMO2/TXN2/GSTM5/CTSL/CYBA/CALM3/BCL2/MAP3K5/MGST1/MAP2K6/PIK3R2	1.98873213488507
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	7/608	52/9376	2.07591093117409	APOE/LRPAP1/PLTP/APOC1/VDAC1/VDAC2/ANGPTL4	2.04863230379874
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	10/608	86/9376	1.79314565483476	CACNA1D/KCNMB1/CREB3L1/GNAS/SLC2A1/PRKCA/ADCY3/ABCC8/PRKACA/ATP1A2	1.94572507250696
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	9/608	75/9376	1.85052631578947	GAPDH/TPI1/ASS1/ALDOA/PKM/BCAT1/ENO1/PYCR1/PGAM1	1.94733523604344
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	9/608	75/9376	1.85052631578947	GSTP1/GSTM5/CYCS/BCL2/BAX/MAP3K5/MGST1/ERCC1/PIK3R2	1.94733523604344
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	21/608	224/9376	1.44572368421053	HLA-B/B2M/CCND1/CREB3L1/RANBP1/HLA-A/SLC25A6/RAN/SLC2A1/ANAPC11/PTEN/VDAC1/ADCY3/SLC25A5/BAX/VDAC2/ELK1/PRKACA/ANAPC16/ETS1/PIK3R2	1.77794725240846
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	9/608	76/9376	1.82617728531856	CALM1/GNAI2/SLC26A7/GNAS/PRKCA/CALM3/ADCY3/PRKACA/ATP1A2	1.90425774032614
Human Diseases	Cancer: specific types	hsa05214	Glioma	9/608	76/9376	1.82617728531856	PDGFRB/IGF1/CCND1/CALM1/PRKCA/CALM3/PTEN/BAX/PIK3R2	1.90425774032614
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	7/608	54/9376	1.9990253411306	SRM/TST/LDHB/BHMT2/BCAT1/MPST/MDH2	1.93867938611228
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	21/608	226/9376	1.43292966930601	CACNA1D/MYL9/CREB3L1/CALM1/ATP2B1/GNAI2/EDN3/GNAS/F2R/ATP2B4/CALM3/PLCE1/EDNRA/PDE4A/FXYD1/ADCY3/GRIA2/GRIA4/PRKACA/ATP1A2/PIK3R2	1.73479507076969
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	6/608	44/9376	2.10287081339713	DYNLL1/CREB3L1/GNAS/ARHGDIA/ADCY3/PRKACA	1.9308599481477
Genetic Information Processing	Transcription	hsa03040	Spliceosome	22/608	243/9376	1.39614468269439	LSM7/SNRPD2/FUS/SRSF2/HNRNPA1/SNRPD3/SF3B6/SNRPB2/SF3B5/SNU13/SNRPB/SNRPE/SRSF3/SNRPG/SNRPC/LSM3/SNRPF/LSM4/SNRPD1/SNRPA1/SF3B2/RBM8A	1.64754541993128
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	13/608	128/9376	1.56620065789474	NME1/NME4/APRT/NME3/GUCY1A2/AMPD2/NUDT2/PDE4A/GUK1/ADCY3/PDE7B/ENPP3/ITPA	1.69839460342394
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	15/608	154/9376	1.50205058099795	CACNA1D/TPM2/CREB3L1/CALM1/ATP2B1/GNAI2/GNAS/ATP2B4/PRKCA/CALM3/SLC8A1/ADCY3/BCL2/PRKACA/ATP1A2	1.65417873200481
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	15/608	154/9376	1.50205058099795	CACNA1D/MYL9/CCND1/CALM1/GNAI2/GNAS/MYL6/GUCY1A2/PRKCA/CALM3/ADCY3/MYL6B/GNAO1/ELK1/PRKACA	1.65417873200481
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	11/608	105/9376	1.61553884711779	CACNA1D/TPM2/IGF1/ITGA6/GNAS/LAMA2/SLC8A1/ADCY3/SSPN/ITGA1/PRKACA	1.67022116612758
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	10/608	93/9376	1.65817770232032	CCND1/ITGA6/LAMC3/LAMB2/LAMA2/PTEN/CYCS/BCL2/BAX/PIK3R2	1.67968414008427
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	6/608	47/9376	1.96864501679731	CACNA1D/PKM/SOCS1/SOCS2/ABCC8/PIK3R2	1.75300513506923
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	15/608	157/9376	1.47334897753939	HLA-B/CACNA1D/CCND1/CALM1/HLA-A/SLC25A6/CALM3/PTEN/VDAC1/SLC25A5/VDAC2/MAP2K6/E2F4/ETS1/PIK3R2	1.5749853531102
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	11/608	107/9376	1.5853418593212	PKM/LDHB/CREB3L1/PRMT1/CALM1/GNAS/SLC2A1/CALM3/PGAM1/PYGL/PRKACA	1.60351190190696
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	8/608	71/9376	1.73758339510749	PDGFRB/PKM/LDHB/SLC2A1/PTEN/PGAM1/PIK3R2/SLC16A3	1.64274167118986
Organismal Systems	Nervous system	hsa04730	Long-term depression	7/608	60/9376	1.79912280701754	IGF1/GNAI2/GNAS/GUCY1A2/PRKCA/GRIA2/GNAO1	1.63516494538591
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	19/608	212/9376	1.38207547169811	PDGFRB/IGF1/CALM1/PFN1/GNAI2/EFNA5/GNAS/F2R/PRKCA/CALM3/PGF/PLCE1/ADCY3/ID1/GNAO1/FGF1/PDGFD/MAP2K6/PIK3R2	1.48170486017019
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	5/608	38/9376	2.02908587257618	HSD11B2/IGF1/PRKCA/ATP1A2/PIK3R2	1.67380028306394
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	12/608	122/9376	1.51682484900777	CACNA1D/IGF1/SOCS1/CREB3L1/SOCS2/GNAI2/GNAS/PRKCA/ADCY3/MAP2K6/PRKACA/PIK3R2	1.51302363235359
Human Diseases	Cancer: specific types	hsa05218	Melanoma	8/608	73/9376	1.68997837058399	PDGFRB/IGF1/CCND1/PTEN/BAX/FGF1/PDGFD/PIK3R2	1.55837708503472
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	11/608	110/9376	1.54210526315789	GAPDH/RPS6/ELOB/ALDOA/IGF1/LDHB/ENO1/SLC2A1/PRKCA/BCL2/PIK3R2	1.50598614246598
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	10/608	98/9376	1.57357679914071	BIN1/PLPP3/CFL1/ARPC2/PRKCA/WASF2/MYO10/ARPC3/PIP5K1B/PIK3R2	1.50301940295377
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	8/608	75/9376	1.64491228070175	IGF1/CCND1/SIVA1/PTEN/CYCS/CD82/BCL2/BAX	1.47656854944218
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	8/608	75/9376	1.64491228070175	CREB3L1/GNAS/PRKCA/GPX1/ADCY3/GPX7/PRKACA/ATP1A2	1.47656854944218
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	9/608	88/9376	1.57715311004785	F3/F13A1/F2R/F2RL2/F10/VWF/CLU/C1QA/BDKRB2	1.4323805995782
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	7/608	65/9376	1.66072874493927	CACNA1D/CREB3L1/GNAS/ADCY3/CACNA1H/PRKACA/KCNK3	1.40756634222139
Human Diseases	Substance dependence	hsa05032	Morphine addiction	9/608	91/9376	1.52515905147484	GNAI2/GNAS/PRKCA/PDE4A/ADCY3/PDE7B/GNAO1/PRKACA/GABRP	1.32558552977808
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	16/608	184/9376	1.34096109839817	MYL9/WNT4/SEMA5A/BMP7/GNAI2/EFNA5/UNC5B/CFL1/EFNB2/MYL12B/PRKCA/PLXNA2/ABLIM1/ABLIM3/PLXNB2/PIK3R2	1.22997389022363
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	7/608	67/9376	1.61115475255302	GAPDH/TPI1/ALDOA/PKM/LDHB/ENO1/PGAM1	1.32197802740201
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	9/608	93/9376	1.49235993208829	CACNA1D/CALM1/GNAS/PRKCA/CALM3/ADCY3/MAP2K6/ELK1/PRKACA	1.25651350118084
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	4/608	32/9376	1.92763157894737	BOK/CYCS/BCL2/BAX	1.38411207118421
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	19/608	227/9376	1.29074889867841	HLA-B/B2M/CCND1/CREB3L1/CALM1/GNAI2/HLA-A/GNAS/PRKCA/CALM3/CYCS/ADCY3/BAX/GNAO1/MAP2K6/ELK1/PRKACA/TAPBP/PIK3R2	1.16770018876446
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	3/608	21/9376	2.20300751879699	BCAT1/COASY/ENPP3	1.45325976693203
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	6/608	56/9376	1.65225563909774	DAD1/DPM3/B4GALT2/TMEM258/MAN1B1/GANAB	1.28911320493066
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	8/608	82/9376	1.50449293966624	GSTP1/CES1/NME1/NME4/NME3/GSTM5/MGST1/ITPA	1.20822506786578
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	6/608	57/9376	1.62326869806094	ECHS1/FASN/ACSL5/FADS2/TECR/FADS1	1.24284006624067
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	9/608	98/9376	1.41621911922664	CALM1/PRKCA/CALM3/ITPK1/PLCE1/PTEN/SYNJ2/PIP5K1B/PIK3R2	1.09067419221833
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	8/608	85/9376	1.45139318885449	NME1/NME4/APRT/NME3/AMPD2/GUK1/ENPP3/ITPA	1.10083034274604
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	10/608	112/9376	1.37687969924812	SOCS1/ITGA6/LAMC3/LAMB2/GNAI2/LAMA2/CYCS/BCL2/GNAO1/MAP2K6	1.05657332034848
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	9/608	99/9376	1.40191387559809	IGF1/CCND1/GNAS/ADCY3/NOTCH1/BCL2/BAX/PRKACA/PIK3R2	1.05860508604099
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	5/608	49/9376	1.57357679914071	GALNT17/B4GALT2/LFNG/FUT11/RFNG	1.05999980396311
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	5/608	49/9376	1.57357679914071	CREB3L1/GNAI2/GNAS/GRIA2/PRKACA	1.05999980396311
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	10/608	115/9376	1.34096109839817	NACA/CREB3L1/WNK2/GNAI2/GNAS/PRKCA/PDE4A/ADCY3/BCL2/PRKACA	0.968750560489298
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	14/608	170/9376	1.26996904024768	IGF2/WNT4/GSTP1/CCND1/GSTM5/PRKCA/SMARCD3/PTEN/FZD4/FZD7/BAX/MGST1/ELK1/PIK3R2	0.935384341093239
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	8/608	89/9376	1.38616203429923	CACNA1D/GNAI2/SLC38A5/PRKCA/ADCY3/GNAO1/PRKACA/GABRP	0.963860119806268
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	6/608	63/9376	1.46867167919799	PTGDS/GPX4/CBR1/EPHX2/PTGES2/CBR3	0.982836646389334
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	9/608	103/9376	1.34747061829331	LAMC3/LAMB2/GNAS/COL1A1/LAMA2/PRKCA/PRKACA/HSPB1/PIK3R2	0.933713690746955
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	7/608	78/9376	1.38394062078273	LSM7/PABPC1/ENO1/PABPC4/LSM3/LSM4/EXOSC5	0.896610355394505
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	11/608	133/9376	1.27542540561931	CACNA1D/CREB3L1/CALM1/GNAI2/GNAS/PRKCA/CALM3/GRIA2/GNAO1/GRIA4/PRKACA	0.84238475555837
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	5/608	52/9376	1.48279352226721	IGF1/GNAS/ADCY3/PRKACA/CYP1B1	0.919282792955787
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	9/608	106/9376	1.30933465739821	GSTP1/PDGFRB/IGF1/CCND1/CREB3L1/PTEN/BCL2/PDGFD/PIK3R2	0.843390691245852
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/608	27/9376	1.71345029239766	FADS2/TECR/FADS1	0.977575209610495
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	19/608	248/9376	1.18145161290323	GAPDH/MYL9/TXN/RPS3/DYNLL1/PFN1/TXN2/TNFSF10/TUBA1B/ARPC2/MYL12B/FLNA/CYCS/BCL2/BAX/ARPC3/CASP4/MAP2K6/EXOC7	0.762581060518196
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	11/608	137/9376	1.23818670764502	CTSC/CTSH/CTSL/TNFSF10/TUBA1B/CYCS/BCL2/BAX/MAP3K5/CTSD/PIK3R2	0.739524350481666
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	7/608	82/9376	1.31643132220796	HLA-B/B2M/HLA-A/PSME2/PSME1/CTSL/TAPBP	0.757830735951438
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	11/608	138/9376	1.22921434019832	RPS6/SOCS1/SOCS2/CALM1/CALM3/FASN/PYGL/EXOC7/ELK1/PRKACA/PIK3R2	0.714298118482413
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	10/608	125/9376	1.23368421052632	GNAI2/PRKCA/PTEN/BCL2/BAX/MAP3K5/CTSD/SMPD1/BDKRB2/PIK3R2	0.692591556125411
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	13/608	168/9376	1.19329573934837	PPIA/IL33/TNFSF10/SLC25A6/VDAC1/SLC25A5/BCL2/BAX/VDAC2/PYGL/CHMP2A/SMPD1/CHMP1A	0.665704394979507
Organismal Systems	Immune system	hsa04611	Platelet activation	10/608	126/9376	1.22389306599833	GNAI2/GNAS/F2R/COL1A1/GUCY1A2/MYL12B/ADCY3/VWF/PRKACA/PIK3R2	0.666257647585163
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	6/608	70/9376	1.3218045112782	HLA-B/CCND1/HLA-A/LAMA2/CYCS/SSPN	0.711617764737443
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	12/608	155/9376	1.19388794567063	HLA-B/SEC61A1/THBS2/HLA-A/SEC61B/CTSL/TUBA1B/CYBA/MRC2/SEC61G/TCIRG1/COLEC12	0.640936204848842
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	12/608	155/9376	1.19388794567063	CACNA1D/WNT4/CCND1/CREB3L1/GNAI2/GNAS/ADCY3/FZD4/CACNA1H/FZD7/PRKACA/KCNK3	0.640936204848842
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	8/608	99/9376	1.2461456671983	CACNA1D/TPM2/IGF1/ITGA6/LAMA2/SLC8A1/SSPN/ITGA1	0.648325601636218
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	16/608	214/9376	1.15297589768815	HLA-B/B2M/ELOB/CALM1/GNAI2/HLA-A/CFL1/PRKCA/CALM3/CYCS/BCL2/BAX/GNAO1/MAP2K6/TAPBP/PIK3R2	0.596103827810747
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	4/608	44/9376	1.40191387559809	DAD1/B4GALT2/TMEM258/MAN1B1	0.703653950734953
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	26/608	362/9376	1.10758941552777	IGF2/RPS6/PDGFRB/IGF1/CCND1/ITGA6/CREB3L1/THBS2/LAMC3/DDIT4/LAMB2/EFNA5/F2R/COL1A1/LAMA2/PRKCA/PGF/PTEN/BCL2/VWF/FGF1/PDGFD/COL6A3/MLST8/ITGA1/PIK3R2	0.549733513711636
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	7/608	86/9376	1.25520195838433	CACNA1D/ITGA6/GJA1/LAMA2/SLC8A1/SSPN/ITGA1	0.626055058052009
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/608	18/9376	1.71345029239766	FASN/ACSL5	0.797802898241073
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	2/608	18/9376	1.71345029239766	CD320/MMAB	0.797802898241073
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	12/608	158/9376	1.17121918720853	RPS6/WNT4/IGF1/DDIT4/LAMTOR4/PRKCA/PTEN/FZD4/FZD7/SEC13/MLST8/PIK3R2	0.571544144759643
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	9/608	115/9376	1.20686498855835	CACNA1D/CREB3L1/GNAI2/PRKCA/ADCY3/BCL2/GNAO1/PRKACA/PIK3R2	0.587752017907601
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	8/608	101/9376	1.22146951537259	F3/CCND1/COL1A1/PRKCA/PLCE1/BCL2/BAX/PIK3R2	0.58925712205672
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	10/608	130/9376	1.18623481781377	CREB3L1/ACTA2/GNAI2/GNAS/COL1A1/PRKCA/ADCY3/GNAO1/PRKACA/PIK3R2	0.563044560660587
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	17/608	232/9376	1.12999092558984	MYL9/TMSB4X/PDGFRB/ITGA6/PFN1/F2R/CFL1/ARPC2/MYL12B/WASF2/ARPC3/FGF1/PDGFD/ITGA1/BDKRB2/PIP5K1B/PIK3R2	0.527929678284152
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	5/608	59/9376	1.30686886708296	NME1/NME4/NME3/NUDT2/ENPP3	0.622626993602409
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	5/608	59/9376	1.30686886708296	GNAI2/GNAS/ADCY3/PRKACA/PIK3R2	0.622626993602409
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	5/608	59/9376	1.30686886708296	CCND1/PTEN/BAX/ELK1/PIK3R2	0.622626993602409
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	9/608	116/9376	1.1964609800363	GAPDH/TPI1/ALDOA/GCSH/PKM/ENO1/ECHS1/MDH2/PGAM1	0.560643723752641
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	9/608	116/9376	1.1964609800363	CACNA1D/GNAI2/GNAS/PRKCA/ADCY3/GRIA2/GNAO1/GRIA4/PRKACA	0.560643723752641
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	8/608	103/9376	1.19775166070516	PABPC1/FUS/PABPC4/SSU72/PABPN1/SAP18/RBM8A/CPSF1	0.531392938704517
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	18/608	250/9376	1.11031578947368	HLA-B/PSD/BIN1/HLA-A/AP2M1/ARPC2/AP2S1/AP2A1/ACAP1/DNM1/ARPC3/VPS28/EHD2/CHMP2A/SH3GL1/CAPZB/PIP5K1B/CHMP1A	0.465537432151997
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	11/608	148/9376	1.14615931721195	WNT4/IGF1/CCND1/HEYL/PTEN/NOTCH1/FZD4/FZD7/BAX/FGF1/PIK3R2	0.47194428085988
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	13/608	178/9376	1.12625665286813	WNT4/APCDD1/CCND1/DAAM2/PRICKLE1/PRKCA/DAAM1/FZD4/FZD7/TLE1/RUVBL1/PRKACA/TLE2	0.447821280629838
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	9/608	120/9376	1.15657894736842	CALM1/MAGED1/ARHGDIA/BEX3/CALM3/BCL2/BAX/MAP3K5/PIK3R2	0.454568645572577
NA	NA	hsa03272	Virion - Hepatitis viruses	4/608	48/9376	1.28508771929825	CD81/HSPG2/CD63/CHMP1A	0.521425200596373
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	4/608	48/9376	1.28508771929825	CACNA1D/SLC37A4/ATP1A2/PIK3R2	0.521425200596373
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	3/608	34/9376	1.36068111455108	RORB/BHLHE41/DBP	0.554791868860911
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	5/608	63/9376	1.22389306599833	WNT4/GLI2/FZD4/FZD7/BAX	0.46951911093109
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	9/608	122/9376	1.13761863675582	WNT4/CCND1/SLC2A1/PRKCA/PLCE1/NOTCH1/PRKACA/ATP1A2/PIK3R2	0.402883588247743
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	6/608	78/9376	1.18623481781377	TPI1/ITPK1/PLCE1/PTEN/SYNJ2/PIP5K1B	0.434911174145665
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	8/608	108/9376	1.14230019493177	EEF1A1/SUMO2/RAN/SAP18/SEC13/UBE2I/RBM8A/IPO4	0.39166207230421
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	6/608	79/9376	1.17121918720853	GSTP1/GSTM5/CBR1/CBR3/MGST1/CYP1B1	0.40242200313837
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	4/608	50/9376	1.23368421052632	SRM/CKB/PYCR1/CNDP2	0.436268466234556
NA	NA	hsa04082	Neuroactive ligand signaling	14/608	199/9376	1.08489817508596	PENK/HTR2B/ADRA2C/GNAI2/GNAS/PRKCA/ADCY3/ADRA2A/GRIA2/SLC17A9/GNAO1/GRIA4/PRKACA/GABRP	0.318758434080334
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/608	22/9376	1.40191387559809	ASPA/CNDP2	0.496973023129217
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	12/608	170/9376	1.08854489164087	CACNA1D/MYL9/CCND1/MYL6/TUBA1B/ARPC2/LLGL1/MYL12B/MYL6B/MAP3K5/ARPC3/PRKACA	0.30678890086315
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	5/608	67/9376	1.15082482325216	CALM1/PRKCA/CALM3/GRIA2/PRKACA	0.326246505477102
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/608	23/9376	1.34096109839817	CA4/ATP1A2	0.431102398920697
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/608	38/9376	1.21745152354571	NAPRT/QPRT/ENPP3	0.35368323612522
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	7/608	99/9376	1.09037745879851	PDGFRB/PLPP3/PRKCA/WASF2/PDGFD/PIP5K1B/PIK3R2	0.238046117231441
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/608	24/9376	1.28508771929825	HS6ST1/NDST1	0.368229890411849
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	3/608	39/9376	1.18623481781377	GCSH/BHMT2/CHDH	0.30688570549834
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	16/608	238/9376	1.03670942061035	IGF2/PDGFRB/IGF1/RASA4/CALM1/EFNA5/PRKCA/CALM3/PGF/PLCE1/FGF1/PDGFD/ELK1/PRKACA/ETS1/PIK3R2	0.15105238574041
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	5/608	70/9376	1.1015037593985	GSTP1/GSTM5/CBR1/MGST1/CYP1B1	0.224458874391483
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	4/608	56/9376	1.1015037593985	CCND1/GLI2/BCL2/PRKACA	0.200611276847999
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	3/608	41/9376	1.12836970474968	GCSH/CHDH/PGAM1	0.216912443571433
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	3/608	41/9376	1.12836970474968	GRIA2/GRIA4/GABRP	0.216912443571433
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	10/608	149/9376	1.03496997527375	PDGFRB/GNAS/PLPP3/F2R/PRKCA/ADCY3/DNM1/PDGFD/PIP5K1B/PIK3R2	0.11330402980855
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/608	42/9376	1.1015037593985	ECHS1/HAAO/CYP1B1	0.1736041216035
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	3/608	42/9376	1.1015037593985	GPX4/ACSL5/VDAC2	0.1736041216035
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	7/608	105/9376	1.0280701754386	UBA52/RPS27A/TOMM7/FIS1/TOMM40/PHB2/MTX1	0.0761664375432775
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	6/608	90/9376	1.0280701754386	IGF1/CREB3L1/ADCY3/BAX/PRKACA/PIK3R2	0.0704594419705595
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	3/608	43/9376	1.07588739290086	ECHS1/ECI1/ACSL5	0.131334971780707
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	10/608	154/9376	1.00136705399863	NAPRT/NME1/NME4/BCAT1/NME3/QPRT/VKORC1/HAAO/MMAB/COASY	0.0045042307202307
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	14/608	217/9376	0.99490662139219	CACNA1D/CCND1/CREB3L1/GNAI2/GNAS/GSTM5/PRKCA/ADCY3/EPHX2/BCL2/MGST1/PRKACA/CYP1B1/PIK3R2	-0.0199893629960877
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/608	28/9376	1.1015037593985	ECHS1/TECR	0.141640988371304
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/608	28/9376	1.1015037593985	B4GALT2/B3GALT1	0.141640988371304
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	3/608	44/9376	1.05143540669856	HLA-B/PTPRN2/HLA-A	0.0900509520285804
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/608	12/9376	1.28508771929825	VKORC1	0.260210961479055
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	5/608	76/9376	1.01454293628809	PLTP/DBI/ACSL5/FADS2/ANGPTL4	0.0335200440459758
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	16/608	250/9376	0.986947368421053	CTSC/CTSH/AP2M1/CD63/CTSL/FUCA2/LAMTOR4/AP2S1/AP2A1/LITAF/TCIRG1/SLC29A1/CTSD/HYAL2/MLST8/SMPD1	-0.0550826732698926
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	9/608	140/9376	0.991353383458647	RPS6/CCND1/ACTA2/CALM1/GNAI2/CALM3/SLC8A1/ADCY3/PRKACA	-0.0271428478574585
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/608	29/9376	1.06352087114338	CALM1/CALM3	0.0902124505753526
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	13/608	205/9376	0.977920410783055	HLA-B/B2M/CCND1/SEM1/HLA-A/NCOR2/CYCS/PSMC3/BCL2/BAX/MAP2K6/TAPBP/PIK3R2	-0.0841679462606879
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	7/608	110/9376	0.98133971291866	IGF1/GNAI2/ANAPC11/ADCY3/PRKACA/ANAPC16/PIK3R2	-0.0518388875164811
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	5/608	78/9376	0.988529014844804	ARPC2/WASF2/DNM1/ARPC3/PIK3R2	-0.0267880071031751
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	5/608	78/9376	0.988529014844804	CALM1/GNAI2/CFL1/CALM3/C1QA	-0.0267880071031751
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	4/608	62/9376	0.99490662139219	IGF1/ADCY3/PRKACA/PIK3R2	-0.0105954851014665
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	16/608	253/9376	0.975244435198669	MYL9/UBA52/RPS27A/PFN1/CAPNS1/ARPC2/MYL12B/PLCE1/WASF2/VDAC1/CYCS/BCL2/BAX/ARPC3/CASP4/PIK3R2	-0.105111787028556
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/608	13/9376	1.18623481781377	XRCC6	0.176934368418146
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	5/608	79/9376	0.97601598934044	AP2M1/AP2S1/AP2A1/TCIRG1/DNM1	-0.0563703973267756
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	3/608	47/9376	0.984322508398656	PKM/LDHB/MDH2	-0.0283723374462071
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/608	31/9376	0.99490662139219	ECHS1/CNDP2	-0.00747970227289177
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	2/608	31/9376	0.99490662139219	GCSH/MDH2	-0.00747970227289177
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/608	14/9376	1.1015037593985	B4GALT2	0.100080388884837
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	4/608	65/9376	0.948987854251012	CACNA1D/PRKCA/CACNA1H/PIK3R2	-0.108672401421505
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/608	32/9376	0.963815789473684	LDHB/ECHS1	-0.0539901871738519
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	7/608	115/9376	0.938672768878719	CACNA1D/HTR2B/GNAI2/GNAS/PRKCA/GNAO1/PRKACA	-0.174245067255793
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	12/608	196/9376	0.944146079484425	HLA-B/UBA52/RPS27A/CCND1/CALM1/HLA-A/CALM3/CYCS/BAX/MAP2K6/CLEC2B/PIK3R2	-0.20808822946925
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	11/608	180/9376	0.942397660818713	HLA-B/B2M/SRSF2/HLA-A/CYCS/SRSF3/CARD9/BCL2/BAX/TAPBP/PIK3R2	-0.205477393785565
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	7/608	116/9376	0.930580762250454	MYL9/GNAI2/CD99/CYBA/MYL12B/PRKCA/PIK3R2	-0.198102747653936
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	3/608	50/9376	0.925263157894737	CD81/THBS2/HBA2	-0.139527302264205
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	7/608	117/9376	0.922627080521817	SMARCD3/RUVBL2/ZNHIT1/MBD3/RUVBL1/CHD4/BCL7C	-0.221761949237542
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	12/608	200/9376	0.925263157894737	GAPDH/RPS3/F2R/TNFSF10/TUBA1B/ARPC2/WASF2/CYCS/MYO10/BAX/ARPC3/CASP4	-0.281326210395176
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	6/608	102/9376	0.907120743034056	ATP2B1/GNAS/ATP2B4/PRKCA/ADCY3/ATP1A2	-0.248354726603237
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/608	16/9376	0.963815789473684	MIF	-0.0381441837448189
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	10/608	169/9376	0.912488321395204	UBA52/RPS27A/DDIT4/CTSL/PTEN/BCL2/CTSD/MLST8/PRKACA/PIK3R2	-0.30229951634066
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	6/608	103/9376	0.898313745528871	COL15A1/COL5A1/COL1A1/SLC8A1/COL6A3/ATP1A2	-0.273248565380359
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	6/608	103/9376	0.898313745528871	GNAI2/GNAS/GNAO1/C1QA/BDKRB2/PIK3R2	-0.273248565380359
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/608	35/9376	0.881203007518797	TPI1/ALDOA	-0.18540862765594
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	5/608	87/9376	0.88626739261948	CCND1/CYCS/BCL2/BAX/PIK3R2	-0.280638530642761
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	4/608	70/9376	0.881203007518797	ELOB/SLC2A1/ETS1/PIK3R2	-0.262700015954476
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	11/608	187/9376	0.907120743034056	TXNIP/TXN/TXN2/CYBA/CARD16/VDAC1/CARD9/BCL2/VDAC2/CASP4/GBP4	-0.337825608079746
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/608	17/9376	0.907120743034056	CA4	-0.100928920148524
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	4/608	71/9376	0.868791697553744	CCND1/SOCS1/SOCS2/PIK3R2	-0.292226407839804
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/608	36/9376	0.85672514619883	PYGL/ENPP3	-0.226795766500369
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	10/608	173/9376	0.891390325524795	IL33/TNFSF10/SLC25A6/PRKCA/VDAC1/CYCS/PABPN1/SLC25A5/BAX/PIK3R2	-0.379676755666507
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	9/608	157/9376	0.884009386523634	WNT4/CCND1/BMP7/LLGL1/GLI2/FZD4/FZD7/ID1/FGF1	-0.38593833723522
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/608	18/9376	0.85672514619883	FUCA2	-0.160214516450052
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/608	37/9376	0.833570412517781	ASS1/ASPA	-0.267096605295174
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	2/608	37/9376	0.833570412517781	PRKCA/HBA2	-0.267096605295174
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	2/608	37/9376	0.833570412517781	CCND1/BAX	-0.267096605295174
Organismal Systems	Digestive system	hsa04976	Bile secretion	5/608	90/9376	0.85672514619883	GNAS/SLC2A1/ADCY3/PRKACA/ATP1A2	-0.359636735058065
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	4/608	73/9376	0.844989185291997	CCND1/PRKCA/BAX/PIK3R2	-0.35010561471522
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	8/608	142/9376	0.868791697553744	UBA52/ELOB/RPS27A/SOCS1/ANAPC11/STUB1/UBE2I/ANAPC16	-0.414856320417981
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	3/608	56/9376	0.826127819548872	EEF1A1/CYCS/RAB1B	-0.343639687193332
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	6/608	109/9376	0.848865282472236	CREB3L1/SLC2A1/PTEN/PYGL/PPARGC1B/PIK3R2	-0.417921836180861
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	9/608	160/9376	0.867434210526316	HLA-B/ITGA6/HLA-A/CD99/CD34/NLGN3/CNTN1/ICAM3/NLGN2	-0.445356072214177
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/608	19/9376	0.811634349030471	HYAL2	-0.216419980616477
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/608	19/9376	0.811634349030471	GCSH	-0.216419980616477
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	8/608	144/9376	0.85672514619883	WNT4/MEIS1/IGF1/FZD4/FZD7/ID1/PCGF2/PIK3R2	-0.456236975323342
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/608	39/9376	0.790823211875843	HLA-B/HLA-A	-0.3446904663206
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	9/608	163/9376	0.851469163706813	CREB3L1/HSPG2/PRKCA/CYCS/BCL2/BAX/MAP2K6/ELK1/PIK3R2	-0.503729111375725
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/608	20/9376	0.771052631578947	EBP	-0.269893673517146
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/608	20/9376	0.771052631578947	NANS	-0.269893673517146
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	4/608	77/9376	0.801093643198906	CCND1/BAX/BCR/PIK3R2	-0.461490811943438
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	10/608	181/9376	0.851991858098284	CALM1/MRC2/CALM3/CYCS/LSP1/CARD9/TCIRG1/BCL2/BAX/CTSD	-0.529463692890328
NA	NA	hsa04517	IgSF CAM signaling	17/608	299/9376	0.876782256644957	MYL9/DYNLL1/UNC5B/MYL6/TUBA1B/ARPC2/MYL12B/PRKCA/NLGN3/PLXNA2/CNTN1/MYL6B/ARPC3/ICAM3/LRFN5/NLGN2/PIK3R2	-0.570196877154505
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	2/608	41/9376	0.752246469833119	SEM1/SSBP1	-0.418641016092866
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	3/608	60/9376	0.771052631578947	PRKCA/HSPB1/PIK3R2	-0.468472064484875
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	8/608	150/9376	0.822456140350877	WNT4/CCND1/FZD4/FZD7/BCL2/BAX/FGF1/PIK3R2	-0.577207171699677
NA	NA	hsa04081	Hormone signaling	12/608	219/9376	0.844989185291997	IGF2/RAMP1/PENK/IGF1/ADRA2C/GNAI2/GNAS/ADCY3/ADRA2A/GNAO1/PRKACA/PIK3R2	-0.611215848074764
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/608	23/9376	0.670480549199085	ASS1	-0.416635875466982
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/608	23/9376	0.670480549199085	B4GALT2	-0.416635875466982
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/608	23/9376	0.670480549199085	SSBP1	-0.416635875466982
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	4/608	83/9376	0.743183259353202	POLR2L/POLR2F/IL33/POLR2E	-0.618830292458617
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/608	45/9376	0.685380116959064	ABCA8/ABCC8	-0.557077329108049
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	2/608	45/9376	0.685380116959064	HLA-B/HLA-A	-0.557077329108049
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	7/608	138/9376	0.782227307398932	IGF1/CALM1/ANAPC11/CALM3/ADCY3/PRKACA/ANAPC16	-0.678642638358499
Cellular Processes	Cell motility	hsa04814	Motor proteins	10/608	194/9376	0.794899620184482	MYL9/TPM2/DYNLL1/ACTA2/MYL6/TUBA1B/MYL12B/MYL6B/MYO10/CAPZB	-0.76012644608385
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	4/608	86/9376	0.717258261933905	NRG2/PRKCA/ELK1/PIK3R2	-0.693614956402945
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	5/608	105/9376	0.734335839598997	CALM1/CALM3/LSP1/CARD9/PIK3R2	-0.720860926748876
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/608	26/9376	0.593117408906883	FADS2	-0.547062737446238
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	16/608	300/9376	0.822456140350877	IGF2/CACNA1D/PDGFRB/IGF1/EFNA5/PRKCA/FLNA/PGF/CACNA1H/MAP3K5/FGF1/PDGFD/MAP2K6/ELK1/PRKACA/HSPB1	-0.823012057463454
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	2/608	48/9376	0.642543859649123	BCAT1/ECHS1	-0.653786982286222
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	3/608	69/9376	0.670480549199085	PRKCA/MAP2K6/PIK3R2	-0.723415651621925
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	11/608	216/9376	0.785331384015595	CALM1/TNFSF10/CYBA/PRKCA/CALM3/CYCS/BCL2/BAX/MAP3K5/MAP2K6/PIK3R2	-0.840494454429155
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/608	27/9376	0.571150097465887	ECHS1	-0.587613513973522
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/608	28/9376	0.550751879699248	CBR1	-0.626892522606325
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/608	28/9376	0.550751879699248	TCIRG1	-0.626892522606325
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	5/608	110/9376	0.700956937799043	DCN/BMP7/EMP3/ID1/E2F4	-0.830751402507711
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/608	51/9376	0.604747162022704	PLPP3/PLD3	-0.745285757675939
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3/608	73/9376	0.633741888968998	GSTP1/GSTM5/MGST1	-0.827226289652706
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	4/608	93/9376	0.663271080928127	MYL9/MYL12B/WASF2/SNAI1	-0.859339693336319
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	10/608	205/9376	0.752246469833119	HLA-B/PKM/CCND1/CREB3L1/RANBP1/HLA-A/BAX/CHD4/PRKACA/PIK3R2	-0.94444265280888
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/608	30/9376	0.514035087719298	MDH2	-0.702004360363307
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/608	30/9376	0.514035087719298	GPAA1	-0.702004360363307
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	6/608	133/9376	0.695686584883261	IGF1/CCND1/PRMT1/TNFSF10/PTEN/PIK3R2	-0.930738329058026
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/608	54/9376	0.571150097465887	HLA-B/HLA-A	-0.832213590136005
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/608	31/9376	0.497453310696095	ALDOA	-0.737997290925326
NA	NA	hsa04981	Folate transport and metabolism	1/608	31/9376	0.497453310696095	BHMT2	-0.737997290925326
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/608	55/9376	0.560765550239234	PLPP3/SMPD1	-0.860267751751879
Human Diseases	Infectious disease: viral	hsa05162	Measles	6/608	136/9376	0.680340557275542	RACK1/CCND1/CYCS/BCL2/BAX/PIK3R2	-0.988799330835609
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/608	32/9376	0.481907894736842	B4GALT2	-0.773041316352881
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/608	32/9376	0.481907894736842	MLST8	-0.773041316352881
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	3/608	77/9376	0.60082023239918	CCND1/BAX/PIK3R2	-0.926153382044562
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	3/608	78/9376	0.593117408906883	EEF1A1/CYBA/ELK1	-0.950186369600856
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/608	33/9376	0.467304625199362	BCAT1	-0.807197631220001
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/608	33/9376	0.467304625199362	VTI1B	-0.807197631220001
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	6/608	138/9376	0.670480549199085	ARPC2/WASF2/ARPC3/MAP2K6/PIP5K1B/PIK3R2	-1.02687782756873
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	4/608	99/9376	0.623072833599149	KRT19/KRT10/KRT17/C1QA	-0.99279233598289
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	9/608	195/9376	0.711740890688259	SLC25A6/CYBA/PRKCA/VDAC1/SLC25A5/VWF/VDAC2/CASP4/PIK3R2	-1.07113080530042
NA	NA	hsa04382	Cornified envelope formation	10/608	217/9376	0.710647586708707	S100A6/S100A11/S100A13/KRT19/ITGA6/KRT10/S100A4/KRT17/EPHX2/KAZN	-1.13558619306345
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	5/608	122/9376	0.632010353753235	IGF1/CCND1/CREB3L1/FASN/PIK3R2	-1.07730313722672
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	6/608	142/9376	0.651593773165308	SOCS1/CYBA/FHL2/MAP2K6/PIK3R2/SIRPA	-1.101595879076
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/608	36/9376	0.428362573099415	GALNT17	-0.904868823486168
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/608	36/9376	0.428362573099415	SSBP1	-0.904868823486168
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	3/608	83/9376	0.557387444514902	ACSL5/EPHX2/PRDX5	-1.06652726947189
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	8/608	183/9376	0.674144377336785	NHP2/RPP25/NOP56/RAN/SNU13/PWP2/POP7/GNL3	-1.17222044364785
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/608	37/9376	0.41678520625889	MIF	-0.935979557017276
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/608	37/9376	0.41678520625889	NANS	-0.935979557017276
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	2/608	63/9376	0.489557226399332	PLOD1/ECHS1	-1.07043349544364
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2/608	66/9376	0.467304625199362	HSD11B2/CYP1B1	-1.14357120287226
Human Diseases	Substance dependence	hsa05034	Alcoholism	8/608	191/9376	0.645907963626343	CREB3L1/CALM1/GNAI2/GNAS/CALM3/SLC29A1/GNAO1/PRKACA	-1.3019083728091
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	1/608	41/9376	0.37612323491656	CCND1	-1.05419447575717
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	15/608	323/9376	0.716147955026886	PDGFRB/CCND1/SOCS1/HOXD10/DDIT4/TIMP3/EFNA5/PRKCA/PTEN/NOTCH1/FSCN1/BCL2/UBE2I/CYP1B1/PIK3R2	-1.36704932766826
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	3/608	90/9376	0.514035087719298	PTEN/MAP2K6/PIK3R2	-1.21982908911531
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	5/608	133/9376	0.579738820736051	HLA-B/HLA-A/TNFSF10/PRKCA/PIK3R2	-1.28536294598131
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/608	68/9376	0.453560371517028	ALDH1A2/ALDH1A3	-1.19084603147404
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	2/608	68/9376	0.453560371517028	CCND1/PIK3R2	-1.19084603147404
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/608	43/9376	0.358629130966952	PLPP3	-1.10999234214662
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	6/608	157/9376	0.589339591015756	BSG/ANO4/SLC2A1/C1QA/UQCRFS1/SIRPA	-1.36640018240793
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	2/608	70/9376	0.440601503759398	SLC2A1/ACSL5	-1.2370177966464
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/608	44/9376	0.350478468899522	TAF10	-1.13715504538416
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/608	44/9376	0.350478468899522	NTHL1	-1.13715504538416
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/608	46/9376	0.335240274599542	MMAB	-1.19011780060456
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	4/608	119/9376	0.518354710305175	CREB3L1/MAP3K5/MAP2K6/PIK3R2	-1.39236412044534
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	2/608	73/9376	0.422494592645999	PPIA/RAN	-1.30434696459019
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	5/608	144/9376	0.535453216374269	CCND1/FASN/MAP3K5/MAP2K6/C1QA	-1.47927856029583
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	3/608	100/9376	0.462631578947368	ITGA6/CD34/ITGA1	-1.42258730378936
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	6/608	168/9376	0.550751879699248	PDGFRB/CCND1/SOCS1/SOCS2/BCL2/PIK3R2	-1.54719627617603
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	3/608	104/9376	0.444838056680162	PEMT/PLPP3/PLD3	-1.49912139650818
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/608	54/9376	0.285575048732943	ERCC1	-1.38639218538566
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	2/608	83/9376	0.371591629676601	CBX6/PCGF2	-1.51422424648516
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	5/608	156/9376	0.494264507422402	CD81/CCND1/CYCS/BAX/PIK3R2	-1.67728718736556
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/608	86/9376	0.358629130966952	ASIC2/PRKACA	-1.57339496603958
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	2/608	91/9376	0.338924233661076	CD81/PIK3R2	-1.66866107988584
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	4/608	143/9376	0.431358115568642	SNRPD3/SNRPB/SNRPD1/C1QA	-1.80435755993844
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	2/608	93/9376	0.331635540464063	MAF/NOTCH1	-1.70568097114318
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	2/608	95/9376	0.324653739612188	CTSL/TCIRG1	-1.74212002548731
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/608	65/9376	0.237246963562753	PLPP3	-1.6249111450644
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/608	66/9376	0.233652312599681	MAF	-1.6451675538327
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	1/608	71/9376	0.217197924388436	TCIRG1	-1.74345246711205
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	6/608	201/9376	0.460329929300864	MEIS1/IGF1/FUS/MAF/BAX/NUPR1	-2.03662224444947
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	2/608	105/9376	0.293734335839599	BCL2/UBE2I	-1.91640197318711
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	4/608	158/9376	0.390406395736176	CCND1/ANAPC11/E2F4/ANAPC16	-2.03487506791857
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	2/608	109/9376	0.282955094157412	MAP2K6/PIK3R2	-1.98279209817437
NA	NA	hsa04519	Cadherin signaling	15/608	404/9376	0.572563835330901	KRT19/WNT4/PDGFRB/KRT10/DAAM2/PRICKLE1/GJA1/ARPC2/KRT17/DAAM1/FZD4/FZD7/ARPC3/PSENEN/GABRP	-2.31262103571295
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	13/608	370/9376	0.541820768136558	PENK/HTR2B/ADRA2C/EDN3/F2R/F2RL2/EDNRA/GAL/ADRA2A/GRIA2/GRIA4/GABRP/BDKRB2	-2.36786777860092
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	1/608	100/9376	0.154210526315789	TNFSF10	-2.23907717648336
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	4/608	193/9376	0.319607308426507	GNAI2/ADCY3/PRKACA/PIK3R2	-2.51497203088268
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	1/608	122/9376	0.126402070750647	PIK3R2	-2.55748986270119
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	4/608	298/9376	0.206993995054751	BMP7/IL33/TNFSF10/GDF11	-3.66333534402773
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	6/608	449/9376	0.206071972805064	CALM1/CALM3/SLC8A1/ADCY3/OR2C3/PRKACA	-4.53982062970017