category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Translation	hsa03010	Ribosome	92/760	222/9376	5.11256519677572	RPS26/RPL41/RPL19/RPL14/RPL27A/RPS14/RPL35/RPL10/RPL28/RPS21/RPL4/RPL30/RPL13/RPL35A/RPS28/RPL8/RPL36/RPL5/RPS12/RACK1/RPL38/RPL23A/RPS10/RPS25/FAU/MRPL51/RPL7A/RPL21/RPS27/RPL18A/RPS8/RPL32/RPS3/RPS13/RPS23/RPL27/RPLP2/MRPL20/RPL13A/RPS29/RPS19/MRPS26/MRPS34/RPL18/RPS4X/RPL37/RPL3/RPS27A/MRPS6/MRPS21/RPL24/RPL15/MRPL40/MRPS7/MRPL17/RPL37A/RPL31/RPS5/RPSA/MRPL52/MRPL22/MRPL11/RPL22L1/RPL17/MRPL12/MRPS12/MRPL36/MRPL23/MRPL27/MRPL54/MRPL4/MRPS18C/MRPL55/MRPL21/MRPL15/RPL26L1/RPL36AL/RPS20/MRPL2/MRPL24/MRPS2/MRPS15/MRPL43/MRPL13/MRPL34/MRPS18A/MRPL47/MRPS11/MRPS14/MRPL28/MRPS16/MRPL1	18.4171921113518
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	98/760	268/9376	4.51123330714847	COX4I1/TXN/UQCR10/NDUFA1/NDUFS5/GNAS/COX7C/NDUFB2/COX5B/COX6C/NDUFA4/NDUFB7/UQCRH/COX7B/COX6B1/PSMA7/PSMB1/NDUFAB1/NDUFB10/NDUFB3/COX7A1/SEM1/UQCR11/COX8A/CALM1/NDUFS6/NDUFA2/NDUFS3/PARK7/NDUFB11/NDUFB1/NDUFS8/PSMB6/GNAI2/UQCRQ/NDUFA6/NDUFB8/MT-CO2/NDUFA11/RPS27A/NDUFA13/SLC25A6/PSMB3/COX6A1/COX7A2/PSMB5/CYC1/NDUFA12/NDUFC2/SLC25A5/NDUFA8/TXN2/NDUFB9/COX5A/PSMB4/PSMD8/PSMA5/NDUFB4/NDUFA10/NDUFB5/PSMB2/SOD1/CYCS/MT-ATP8/PSMC2/UQCRFS1/SLC39A3/VDAC2/VDAC1/PRKACA/NDUFA3/NDUFS7/UCHL1/PSMC4/PSMD7/PSMD13/NDUFV2/NDUFA9/TUBA1B/NDUFS4/SLC39A6/MT-ND6/PSMA4/PSMC5/PSMD4/UQCRC1/PSMD14/COX7A2L/UQCRC2/KEAP1/CALM3/ADRM1/NDUFB6/TRAP1/PSMA1/PSMC3/UBE2L3/SLC39A7	17.3202901382477
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	103/760	308/9376	4.12563226247437	COX4I1/POLR2J3/UQCR10/NDUFA1/NDUFS5/COX7C/POLR2L/NDUFB2/COX5B/COX6C/NDUFA4/NDUFB7/UQCRH/COX7B/COX6B1/PSMA7/PSMB1/NDUFAB1/NDUFB10/NDUFB3/COX7A1/SEM1/UQCR11/COX8A/NDUFS6/NDUFA2/NDUFS3/POLR2I/NDUFB11/CREB3L1/NDUFB1/NDUFS8/PSMB6/UQCRQ/NDUFA6/NDUFB8/MT-CO2/NDUFA11/NDUFA13/POLR2F/SLC25A6/PSMB3/COX6A1/COX7A2/PSMB5/POLR2G/CYC1/NDUFA12/NDUFC2/CLTB/SLC25A5/NDUFA8/NDUFB9/COX5A/AP2M1/PSMB4/PSMD8/PSMA5/NDUFB4/NDUFA10/NDUFB5/POLR2E/AP2S1/PSMB2/DCTN3/SOD1/CYCS/MT-ATP8/GPX7/PSMC2/UQCRFS1/CLTA/VDAC2/VDAC1/NDUFA3/NDUFS7/PSMC4/PSMD7/PSMD13/AP2A1/NDUFV2/NDUFA9/TUBA1B/NDUFS4/MT-ND6/PSMA4/PSMC5/PSMD4/UQCRC1/PSMD14/POLR2H/COX7A2L/UQCRC2/POLR2J/POLR2A/WIPI2/ADRM1/NDUFB6/PSMA1/POLR2C/PSMC3/POLR2K/BBC3	16.5652148374836
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	62/760	138/9376	5.54263920671243	COX4I1/UQCR10/NDUFA1/NDUFS5/COX7C/NDUFB2/COX5B/COX6C/NDUFA4/NDUFB7/UQCRH/COX7B/COX6B1/NDUFAB1/NDUFB10/NDUFB3/COX7A1/UQCR11/COX8A/NDUFS6/NDUFA2/NDUFS3/NDUFB11/NDUFB1/NDUFS8/UQCRQ/NDUFA6/NDUFB8/MT-CO2/ATP6V0D1/NDUFA11/NDUFA13/COX6A1/COX7A2/CYC1/NDUFA12/NDUFC2/NDUFA8/NDUFB9/COX5A/NDUFB4/NDUFA10/NDUFB5/CYCS/MT-ATP8/UQCRFS1/NDUFA3/NDUFS7/PPA1/NDUFV2/NDUFA9/NDUFS4/MT-ND6/UQCRC1/TCIRG1/COX7A2L/UQCRC2/NDUFB6/ATP6V1G1/ATP6V1F/ATP6V0B/ATP6V0E2	15.966083577694
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	88/760	275/9376	3.94778947368421	COX4I1/UQCR10/NDUFA1/NDUFS5/CACNA1D/COX7C/NDUFB2/COX5B/COX6C/NDUFA4/NDUFB7/UQCRH/COX7B/COX6B1/PSMA7/PSMB1/NDUFAB1/NDUFB10/NDUFB3/COX7A1/SEM1/UQCR11/COX8A/NDUFS6/NDUFA2/NDUFS3/CYBA/NDUFB11/CREB3L1/NDUFB1/NDUFS8/PSMB6/UQCRQ/NDUFA6/NDUFB8/MT-CO2/NDUFA11/NDUFA13/SLC25A6/PSMB3/COX6A1/COX7A2/PSMB5/CYC1/NDUFA12/NDUFC2/SLC25A5/NDUFA8/NDUFB9/COX5A/PSMB4/PSMD8/PSMA5/NDUFB4/NDUFA10/NDUFB5/PSMB2/SOD1/CYCS/MT-ATP8/PSMC2/UQCRFS1/VDAC2/VDAC1/PRKACA/NDUFA3/NDUFS7/PSMC4/PSMD7/PSMD13/NDUFV2/NDUFA9/TUBA1B/NDUFS4/MT-ND6/PSMA4/PSMC5/PSMD4/UQCRC1/PSMD14/NOTCH1/COX7A2L/UQCRC2/ADRM1/NDUFB6/PSMA1/BAD/PSMC3	14.7352613349805
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	97/760	388/9376	3.08421052631579	GAPDH/COX4I1/WNT4/UQCR10/NDUFA1/NDUFS5/CACNA1D/COX7C/NDUFB2/COX5B/COX6C/NDUFA4/NDUFB7/UQCRH/COX7B/COX6B1/PSMA7/APOE/PSMB1/NDUFAB1/NDUFB10/NDUFB3/COX7A1/SEM1/UQCR11/COX8A/CALM1/NDUFS6/NDUFA2/NDUFS3/NDUFB11/NDUFB1/NDUFS8/PSMB6/BACE2/UQCRQ/NDUFA6/NDUFB8/MT-CO2/NDUFA11/NDUFA13/SLC25A6/PSMB3/COX6A1/COX7A2/PSMB5/CYC1/NDUFA12/NDUFC2/SLC25A5/NDUFA8/MAP2K2/NDUFB9/COX5A/PSMB4/PSMD8/PSMA5/NDUFB4/NDUFA10/NDUFB5/PSMB2/CYCS/MT-ATP8/HSD17B10/PSMC2/UQCRFS1/SLC39A3/VDAC2/VDAC1/NDUFA3/NDUFS7/PSMC4/PSMD7/PSMD13/NDUFV2/NDUFA9/TUBA1B/NDUFS4/PSENEN/SLC39A6/MT-ND6/PSMA4/PSMC5/PSMD4/UQCRC1/PSMD14/COX7A2L/UQCRC2/CAPN1/CALM3/WIPI2/ADRM1/NDUFB6/PSMA1/BAD/PSMC3/SLC39A7	12.4527567598617
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	70/760	227/9376	3.80431254347322	COX4I1/UQCR10/NDUFA1/NDUFS5/COX7C/NDUFB2/COX5B/COX6C/NDUFA4/NDUFB7/UQCRH/COX7B/COX6B1/NDUFAB1/NDUFB10/NDUFB3/COX7A1/UQCR11/COX8A/NDUFS6/NDUFA2/NDUFS3/CYBA/NDUFB11/NDUFB1/NDUFS8/GSTM5/UQCRQ/NDUFA6/NDUFB8/MT-CO2/NDUFA11/NDUFA13/SLC25A6/CBR1/COX6A1/COX7A2/CYC1/NDUFA12/NDUFC2/SLC25A5/NDUFA8/MAP2K2/NQO1/NDUFB9/COX5A/NDUFB4/NDUFA10/NDUFB5/SOD1/MT-ATP8/UQCRFS1/AKR1A1/VDAC2/VDAC1/NDUFA3/GSTO1/NDUFS7/EPHX2/NDUFV2/NDUFA9/NDUFS4/MT-ND6/UQCRC1/COX7A2L/UQCRC2/KEAP1/NDUFB6/BAD/GSTM4	12.7025852588672
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	92/760	368/9376	3.08421052631579	COX4I1/CHCHD10/UQCR10/NDUFA1/NDUFS5/COX7C/NDUFB2/COX5B/COX6C/NDUFA4/NDUFB7/UQCRH/COX7B/COX6B1/PSMA7/NRG2/PSMB1/NDUFAB1/NDUFB10/NDUFB3/COX7A1/SEM1/UQCR11/COX8A/NDUFS6/NDUFA2/NDUFS3/NDUFB11/NDUFB1/NDUFS8/FUS/PSMB6/UQCRQ/NDUFA6/NDUFB8/MT-CO2/NDUFA11/NDUFA13/PSMB3/COX6A1/COX7A2/PSMB5/CYC1/NDUFA12/NDUFC2/NDUFA8/NDUFB9/COX5A/PSMB4/PSMD8/PSMA5/NDUFB4/SRSF3/NDUFA10/NDUFB5/PSMB2/DCTN3/SOD1/SEC13/HNRNPA1/CYCS/MT-ATP8/GPX7/PSMC2/UQCRFS1/VDAC1/NDUFA3/NDUFS7/PSMC4/PSMD7/BCL2/PSMD13/NDUFV2/NDUFA9/TOMM40/TUBA1B/NDUFS4/MT-ND6/PSMA4/PSMC5/PSMD4/UQCRC1/PSMD14/COX7A2L/UQCRC2/WIPI2/ADRM1/NDUFB6/PSMA1/ALYREF/BAD/PSMC3	12.1140927581175
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	66/760	205/9376	3.97186136071887	GAPDH/COX4I1/UQCR10/NDUFA1/NDUFS5/COX7C/NDUFB2/COX5B/COX6C/NDUFA4/NDUFB7/UQCRH/COX7B/COX6B1/NDUFAB1/NDUFB10/NDUFB3/COX7A1/UQCR11/COX8A/NDUFS6/NDUFA2/NDUFS3/CYBA/NDUFB11/NDUFB1/NDUFS8/UQCRQ/NDUFA6/NDUFB8/MT-CO2/NDUFA11/NDUFA13/SLC25A6/COX6A1/COX7A2/CYC1/NDUFA12/NDUFC2/SLC25A5/NDUFA8/NDUFB9/COX5A/NDUFB4/NDUFA10/NDUFB5/MT-ATP8/UQCRFS1/VDAC2/VDAC1/NDUFA3/NDUFS7/PPP1CA/SLC2A1/NDUFV2/NDUFA9/CTSD/PTPA/NDUFS4/MT-ND6/UQCRC1/PDHA1/COX7A2L/UQCRC2/PDHB/NDUFB6	12.7772301747433
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	54/760	157/9376	4.24324505531344	COX4I1/UQCR10/NDUFA1/NDUFS5/COX7C/NDUFB2/COX5B/COX6C/NDUFA4/NDUFB7/UQCRH/COX7B/COX6B1/NDUFAB1/NDUFB10/NDUFB3/COX7A1/UQCR11/COX8A/NDUFS6/NDUFA2/NDUFS3/NDUFB11/NDUFB1/NDUFS8/UQCRQ/NDUFA6/NDUFB8/MT-CO2/NDUFA11/NDUFA13/COX6A1/COX7A2/CYC1/NDUFA12/NDUFC2/NDUFA8/NDUFB9/COX5A/NDUFB4/NDUFA10/NDUFB5/CYCS/UQCRFS1/NDUFA3/NDUFS7/NDUFV2/NDUFA9/NDUFS4/UQCRC1/COX7A2L/UQCRC2/PRKAG1/NDUFB6	12.1710283083565
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	67/760	235/9376	3.5173124300112	COX4I1/UQCR10/NDUFA1/NDUFS5/GNAS/COX7C/NDUFB2/COX5B/COX6C/NDUFA4/NDUFB7/UQCRH/COX7B/COX6B1/NDUFAB1/NDUFB10/NDUFB3/COX7A1/UQCR11/COX8A/NDUFS6/NDUFA2/NDUFS3/NDUFB11/CREB3L1/NDUFB1/NDUFS8/NDUFAF8/UQCRQ/NDUFA6/NDUFB8/MT-CO2/NDUFA11/NDUFA13/NDUFAF3/COX6A1/COX7A2/CYC1/NDUFA12/NDUFC2/NDUFA8/NDUFB9/COX5A/NDUFB4/NDUFA10/NDUFB5/COX14/SMARCD3/MT-ATP8/UQCRFS1/NDUFAF2/PRKACA/NDUFA3/NDUFS7/COA4/NDUFV2/NDUFA9/NDUFS4/MT-ND6/COA3/UQCRC1/COX7A2L/UQCRC2/MLST8/PRKAG1/NDUFB6/RPS6KB2	11.6068343447379
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	101/760	480/9376	2.59587719298246	COX4I1/WNT4/UQCR10/NDUFA1/NDUFS5/CACNA1D/COX7C/NDUFB2/COX5B/COX6C/NDUFA4/NDUFB7/UQCRH/COX7B/COX6B1/PSMA7/PSMB1/NDUFAB1/NDUFB10/NDUFB3/COX7A1/SEM1/UQCR11/COX8A/CALM1/NDUFS6/NDUFA2/NDUFS3/PARK7/NDUFB11/NDUFB1/NDUFS8/FUS/PSMB6/UQCRQ/NDUFA6/NDUFB8/MT-CO2/NDUFA11/RPS27A/NDUFA13/SLC25A6/PSMB3/COX6A1/COX7A2/PSMB5/CYC1/NDUFA12/NDUFC2/SLC25A5/NDUFA8/MAP2K2/NDUFB9/COX5A/PSMB4/PSMD8/PSMA5/NDUFB4/NDUFA10/NDUFB5/PSMB2/DCTN3/SOD1/CYCS/MT-ATP8/HSD17B10/GPX7/PSMC2/UQCRFS1/VDAC2/VDAC1/NDUFA3/NDUFS7/UCHL1/PSMC4/PSMD7/BCL2/PSMD13/NDUFV2/NDUFA9/TOMM40/TUBA1B/NDUFS4/MT-ND6/PSMA4/PSMC5/PSMD4/UQCRC1/PSMD14/COX7A2L/UQCRC2/CAPN1/CALM3/WIPI2/ADRM1/NDUFB6/TRAP1/PSMA1/BAD/PSMC3/UBE2L3	10.660124796537
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	28/760	46/9376	7.50938215102975	PSMA7/PSMB1/SEM1/PSMB6/PSME2/PSMB3/PSMB5/POMP/PSMB4/PSMB8/PSMD8/PSMA5/PSMB2/PSMC2/PSMC4/PSMB9/PSMD7/PSMD13/PSMA4/PSMC5/PSMD4/PSMF1/PSMD14/PSMB10/PSME1/ADRM1/PSMA1/PSMC3	13.1436943696808
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	56/760	238/9376	2.90278637770898	RPS26/RPL41/RPL19/RPL14/RPL27A/RPS14/RPL35/RPL10/RPL28/RPS21/RPL4/RPL30/RPL13/RPL35A/RPS28/RPL8/RPL36/RPL5/RPS12/RPL38/RPL23A/RPS10/RPS25/FAU/RPL7A/RPL21/RPS27/RPL18A/RPS8/RPL32/RPS3/RPS13/RPS23/RPL27/RPLP2/RPL13A/RPS29/RPS19/RPL18/RPS4X/RPL37/RPL3/RPS27A/RPL24/RPL15/RPL37A/F13A1/RPL31/RPS5/RPSA/RPL22L1/RPL17/RPL26L1/RPL36AL/RPS20/ISG15	8.83064700021651
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	37/760	149/9376	3.06351112681031	NDUFA1/NDUFS5/CACNA1D/NDUFB2/NDUFA4/NDUFB7/NDUFAB1/NDUFB10/NDUFB3/NDUFS6/NDUFA2/NDUFS3/NDUFB11/NDUFB1/NDUFS8/GNAI2/NDUFA6/NDUFB8/NDUFA11/NDUFA13/NDUFA12/NDUFC2/NDUFA8/NDUFB9/NDUFB4/NDUFA10/NDUFB5/PRKACA/NDUFA3/NDUFS7/NDUFV2/NDUFA9/NDUFS4/MT-ND6/GNG11/NDUFB6/GNG5	7.54065858897642
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	24/760	87/9376	3.4032667876588	COX4I1/UQCR10/CACNA1D/COX7C/COX5B/COX6C/UQCRH/COX7B/COX6B1/COX7A1/UQCR11/COX8A/UQCRQ/MT-CO2/COX6A1/COX7A2/CYC1/COX5A/UQCRFS1/UQCRC1/COX7A2L/UQCRC2/SLC8A1/ATP1A2	6.68831499770714
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	17/760	63/9376	3.32898913951546	POLR2J3/POLR2L/CETN2/POLR2I/POLR2F/POLR2G/POLR2E/RBX1/ERCC1/POLD2/GTF2H5/POLR2H/POLR2J/POLR2A/POLR2C/POLR2K/RPA2	5.50848949814372
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	15/760	51/9376	3.62848297213622	GNAS/SEC61B/KDELR2/SEC61G/ATP6V0D1/KDELR3/SEC61A1/KDELR1/PRKACA/TCIRG1/ARF1/ATP6V1G1/ATP6V1F/ATP6V0B/ATP6V0E2	5.58991784252469
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	12/760	34/9376	4.35417956656347	POLR2J3/POLR2L/POLR2I/POLR2F/POLR2G/POLR2E/POLR2H/POLR2J/POLR2A/POLR1C/POLR2C/POLR2K	5.81896071458003
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	28/760	144/9376	2.39883040935673	PSMA7/PSMB1/SEM1/PSMB6/SLC25A6/PSMB3/PSMB5/SLC25A5/PSMB4/PSMD8/PSMA5/PSMB2/CYCS/PSMC2/VDAC2/VDAC1/PSMC4/PSMD7/NOP56/PSMD13/PSMA4/PSMC5/PSMD4/PSMD14/WIPI2/ADRM1/PSMA1/PSMC3	5.02386548150484
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	24/760	116/9376	2.5524500907441	GAPDH/TPI1/GCSH/ECHS1/MDH2/ENO1/PKM/IDH3G/PGAM1/ALDOA/MDH1/TKT/SDSL/FH/PGK1/PDHA1/TALDO1/PDHB/PGLS/ACO2/SUCLG1/SUCLG2/PFKP/ESD	4.99667080174956
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	11/760	31/9376	4.37758913412564	SEC11A/SEC61B/SPCS1/SEC61G/SRP14/SEC62/SEC61A1/SRPRB/TMEM208/IMMP1L/SPCS2	5.59419501709795
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	17/760	75/9376	2.79635087719298	GAPDH/TPI1/ENO1/PKM/ASS1/PYCR1/IDH3G/PGAM1/ALDOA/TKT/SDSL/PGK1/ASL/TALDO1/PYCR3/ACO2/PFKP	4.63870302182874
Genetic Information Processing	Transcription	hsa03040	Spliceosome	36/760	243/9376	1.82768031189084	LSM7/SRSF2/SNRPF/FUS/SNRPD2/SF3B5/SNRPD1/SNRPC/SNRPE/SNRPG/SRSF9/SNRPD3/SNU13/SRSF3/MAGOH/HNRNPA1/SNRPB2/CWC15/RBM8A/LSM4/PUF60/SF3B6/SNRPA1/CCDC12/BUD31/SNRPB/LSM3/PRPF31/SF3B2/GPKOW/PHF5A/PPIH/PPIL1/ALYREF/THOC7/SNRPA	3.88238519238123
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	28/760	174/9376	1.98523895946763	SEC61B/TMEM258/RRBP1/SEC61G/DAD1/SEC62/STUB1/SEC61A1/RBX1/OSTC/DDOST/BCAP31/SEC13/MAN1B1/SSR2/P4HB/LMAN2/SSR4/BCL2/KRTCAP2/NSFL1C/BAG1/ERLEC1/CAPN1/UBE2D2/ERP29/HERPUD1/RPN2	3.8959616725976
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	9/760	30/9376	3.70105263157895	MDH2/IDH3G/MDH1/FH/PDHA1/PDHB/ACO2/SUCLG1/SUCLG2	4.40068593205651
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	11/760	44/9376	3.08421052631579	TMEM258/DAD1/OSTC/DDOST/MAN1B1/B4GALT2/ALG3/KRTCAP2/ALG14/HEXA/RPN2	4.11547670095817
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	14/760	67/9376	2.57784760408484	GAPDH/TPI1/LDHB/ENO1/PKM/PGAM1/ALDOA/ALDH2/AKR1A1/PGK1/PDHA1/PDHB/PGM1/PFKP	3.84937773583371
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	16/760	85/9376	2.32222910216718	NME1/NME4/NME3/ITPA/GUK1/APRT/AMPD2/NT5C/AK1/DGUOK/TYMS/ADSL/ASMTL/NT5C3B/NME6/NME2	3.63684283643632
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	24/760	154/9376	1.92262474367738	NAPRT/NME1/NME4/QPRT/NME3/NQO1/ALDH2/AKR1A1/VKORC1/HMBS/AK1/GMPPB/UROS/PMM2/MMAB/ADSL/PPCS/GSS/GMPPA/PMM1/HAAO/COQ4/NME6/NME2	3.42856579701521
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	12/760	56/9376	2.64360902255639	TMEM258/DAD1/DPM3/OSTC/DDOST/MAN1B1/B4GALT2/ALG3/KRTCAP2/DPM2/ALG14/RPN2	3.66373592626945
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	11/760	54/9376	2.5130604288499	LDHB/TST/SRM/MDH2/BHMT2/MPST/MDH1/SDSL/CDO1/ADI1/GSS	3.31160243382389
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	33/760	250/9376	1.62846315789474	CD63/HYAL2/ATP6V0D1/CTSL/CLTB/AP2M1/LAMTOR4/AP2S1/CTSC/LAMTOR5/CLTA/AP1S1/AP2A1/RRAGA/LAPTM4B/BLOC1S4/LAMTOR1/CTSD/TCIRG1/ROGDI/VPS29/FUCA2/SNAPIN/MLST8/ATP6V1G1/ATP6V1F/SLC29A1/CTSH/ATP6V0B/LITAF/HEXA/ATP6V0E2/TELO2	2.99122570760979
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	10/760	47/9376	2.62486002239642	LDHB/MDH2/PKM/MDH1/ALDH2/AKR1A1/GRHPR/FH/PDHA1/PDHB	3.31655287219759
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	7/760	28/9376	3.08421052631579	ECHS1/HADHB/HACD3/TECR/ACAA2/ACOT2/THEM4	3.28020387997615
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	8/760	35/9376	2.81984962406015	TPI1/ALDOA/HSD17B14/GMPPB/PMM2/GMPPA/PMM1/PFKP	3.20340927459312
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	17/760	110/9376	1.9066028708134	GAPDH/LDHB/IGF1/ELOB/ENO1/ALDOA/MAP2K2/RBX1/BCL2/SLC2A1/EIF4EBP1/PGK1/PDHA1/PDHB/PFKP/ELOC/RPS6KB2	2.84057901138165
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	10/760	53/9376	2.32770605759682	GNAS/ATP2B1/CLTB/AP2M1/AP2S1/CLTA/PRKACA/AP2A1/SLC8A1/ATP1A2	2.87873453971383
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	13/760	79/9376	2.03011325782811	ATP6V0D1/CLTB/AP2M1/SYT1/AP2S1/CLTA/AP2A1/TCIRG1/SLC6A9/ATP6V1G1/ATP6V1F/ATP6V0B/ATP6V0E2	2.73065413640564
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	22/760	166/9376	1.63500317057705	CACNA1D/CALM1/CREB3L1/MYL9/GNAI2/SLC25A6/ATP2B1/SLC25A5/MAP2K2/KCNMB1/VDAC2/VDAC1/PPP1CA/EDNRA/ADRA2C/RHOA/GUCY1A2/CALM3/SLC8A1/ATP1A2/BAD/ADRA2A	2.45154411028201
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	18/760	128/9376	1.73486842105263	NME1/NME4/NME3/NUDT2/ITPA/GUK1/APRT/AMPD2/NT5C/AK1/DGUOK/ADSL/NUDT5/GUCY1A2/PAICS/PGM1/NME6/NME2	2.48616671994584
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	10/760	59/9376	2.09099018733274	NME1/NME4/NME3/NUDT2/NT5C/TYMS/ASMTL/NT5C3B/NME6/NME2	2.49659669762261
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	10/760	59/9376	2.09099018733274	GSTP1/SRM/GPX4/GSTM5/PRDX6/GPX7/GSTO1/ODC1/GSS/GSTM4	2.49659669762261
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	18/760	134/9376	1.65718774548311	RAMP1/CACNA1D/GNAS/CALM1/EDN3/MYL9/MAP2K2/KCNMB1/ACTA2/MYL6/PRKACA/MYL6B/PPP1CA/EDNRA/RHOA/GUCY1A2/CALM3/PPP1R14A	2.27561329741203
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	15/760	107/9376	1.72946384653222	LDHB/GNAS/CALM1/PRMT1/CREB3L1/PKM/PGAM1/PRKACA/SLC2A1/PDHA1/PPP4C/PDHB/CALM3/PRKAG1/PFKP	2.2538178251671
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	9/760	56/9376	1.98270676691729	CCND1/PTCH1/PRKACA/BCL2/HHIP/PTCH2/GLI2/GLI1/SMO	2.19053195591682
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	6/760	31/9376	2.38777589134126	ALDOA/TKT/TALDO1/PGLS/PGM1/PFKP	2.298529710956
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	6/760	31/9376	2.38777589134126	GCSH/MDH2/MDH1/GRHPR/ACO2/HYI	2.298529710956
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	3/760	10/9376	3.70105263157895	TST/MPST/SELENBP1	2.53802303386428
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	10/760	71/9376	1.73758339510749	LDHB/PKM/PGAM1/MAP2K2/PDGFRB/SLC16A3/SLC2A1/PDHA1/PDHB/PFKP	1.85277083563483
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	11/760	82/9376	1.65494223363286	GSTP1/NME1/CES1/NME4/NME3/GSTM5/ITPA/GSTO1/NME6/GSTM4/NME2	1.76908287271035
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	17/760	142/9376	1.47694588584136	TXN/GSTP1/CALM1/CYBA/GSTM5/ASS1/CTSL/SUMO2/TXN2/NQO1/GSTO1/BCL2/SUMO1/RHOA/KEAP1/CALM3/GSTM4	1.70081835156121
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	3/760	12/9376	3.08421052631579	NQO1/VKORC1/COQ4	2.14556212787382
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	5/760	28/9376	2.20300751879699	ATP6V0D1/TCIRG1/ATP6V1G1/ATP6V1F/ATP6V0E2	1.8933355728578
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	6/760	37/9376	2.00056899004267	NANS/GMPPB/PMM2/GMPPA/PGM1/PMM1	1.81107861492821
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	6/760	38/9376	1.94792243767313	GMPPB/PMM2/GMPPA/PGM1/PMM1/HEXA	1.73891060464175
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	8/760	57/9376	1.731486611265	ECHS1/HADHB/FADS2/HACD3/TECR/HSD17B8/ACAA2/ACADVL	1.6451243957133
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	10/760	78/9376	1.58164642375169	LSM7/ENO1/EXOSC7/LSM4/LSM3/EXOSC4/MPHOSPH6/EXOSC1/PFKP/DCPS	1.53197324898603
Organismal Systems	Endocrine system	hsa04924	Renin secretion	9/760	69/9376	1.6091533180778	CACNA1D/GNAS/CALM1/EDN3/GNAI2/PRKACA/EDNRA/GUCY1A2/CALM3	1.50829361224313
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	7/760	50/9376	1.72715789473684	CKB/SRM/PYCR1/ALDH2/ODC1/CNDP2/PYCR3	1.53110723755796
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	6/760	41/9376	1.80539152759949	GCSH/PGAM1/CHDH/SDSL/GRHPR/GCAT	1.53490468997735
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	10/760	80/9376	1.54210526315789	NRG2/IGF1/MAP2K2/PDGFRB/GAS6/BCL2/EIF4EBP1/PDGFD/BAD/RPS6KB2	1.4461726667065
Organismal Systems	Digestive system	hsa04978	Mineral absorption	8/760	61/9376	1.61794650560828	MT1X/ATP2B1/MT1E/ATOX1/MT1F/SLC8A1/ATP1A2/HMOX2	1.43801679325751
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	5/760	33/9376	1.86921850079745	VTI1B/GOSR2/STX18/VAMP5/STX8	1.4855331449764
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	7/760	52/9376	1.66072874493927	APOE/PLTP/APOC1/LRPAP1/ANGPTL4/VDAC2/VDAC1	1.4189377066691
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	6/760	43/9376	1.72141982864137	ECHS1/ECI1/ALDH2/HADHB/ACAA2/ACADVL	1.40815758571952
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	5/760	34/9376	1.81424148606811	DBP/RBX1/BHLHE41/RORB/PRKAG1	1.4125776886972
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	9/760	75/9376	1.48042105263158	GSTP1/GSTM5/CYCS/ERCC1/GSTO1/BCL2/BAD/GSTM4/BBC3	1.24058758057034
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	19/760	184/9376	1.27391304347826	WNT4/MYL9/MYL12B/GNAI2/PTCH1/RHOD/BMP7/UNC5B/EFNB1/MYL5/CFL1/EFNB2/RHOA/PLXNA2/SEMA3B/SEMA5A/SRGAP3/ILK/SMO	1.11443875467656
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	4/760	27/9376	1.82768031189084	FADS2/HACD3/TECR/ACOT2	1.2790912148811
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	3/760	18/9376	2.05614035087719	CD320/PRDX1/MMAB	1.33200531234416
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	15/760	142/9376	1.30318754633062	SOCS1/ELOB/RPS27A/ANAPC11/STUB1/RBX1/UBE2I/ANAPC16/ANAPC13/UBE2D2/KEAP1/ANAPC15/UBE2N/UBE2L3/ELOC	1.08118543019667
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	5/760	37/9376	1.66714082503556	ASS1/ASPA/ASL/NIT2/ADSL	1.20755739323476
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	16/760	154/9376	1.28174982911825	CACNA1D/GNAS/CALM1/MYL9/GNAI2/MAP2K2/CCND1/MYL6/PRKACA/MYL6B/PPP1CA/RHOA/ELK1/GUCY1A2/CALM3/PRKAG1	1.04701053602731
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	16/760	155/9376	1.273480475382	SEC61B/HLA-B/SEC61G/CYBA/ATP6V0D1/CTSL/SEC61A1/COLEC12/MRC2/TUBA1B/TCIRG1/ATP6V1G1/ATP6V1F/ATP6V0B/ATP6V0E2/STX18	1.01963034848194
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	3/760	19/9376	1.94792243767313	GCSH/PDHA1/PDHB	1.22834645905246
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	16/760	158/9376	1.24930046635576	WNT4/IGF1/DDIT4/MAP2K2/LAMTOR4/SEC13/LAMTOR5/RRAGA/EIF4EBP1/LAMTOR1/RHOA/MLST8/ATP6V1G1/ATP6V1F/RPS6KB2/TELO2	0.938583406020615
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	22/760	226/9376	1.20093153237075	CACNA1D/GNAS/CALM1/CREB3L1/EDN3/MYL9/GNAI2/ATP2B1/MAP2K2/PTCH1/FXYD1/PRKACA/PPP1CA/EDNRA/HHIP/RHOA/PLCE1/CALM3/HTR1E/ATP1A2/GLI1/BAD	0.908095153942157
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	17/760	170/9376	1.23368421052632	CACNA1D/MYL9/MYL12B/CDK4/ARPC2/CCND1/MYL6/LLGL1/PRKACA/MYL6B/ARPC3/TUBA1B/RHOA/SYMPK/ARPC1B/PRKAG1/ACTN1	0.913183243465319
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	3/760	20/9376	1.85052631578947	NANS/GMPPB/GMPPA	1.13082977735896
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	20/760	205/9376	1.20359435173299	SEM1/HLA-B/CDK4/CCND1/PSMD8/CYCS/PSMC2/PSMC4/PSMD7/BCL2/PSMD13/PSMC5/ISG15/PSMD4/PSMD14/NCOR2/TAPBPL/ADRM1/PSMC3/CIR1	0.875334202582323
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	7/760	62/9376	1.39286926994907	LFNG/HEYL/PSENEN/NOTCH1/NCOR2/CIR1/RFNG	0.921754734459952
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	5/760	41/9376	1.50449293966624	SEM1/SSBP1/POLD2/BABAM1/RPA2	0.961456077719316
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	24/760	253/9376	1.1702933222384	MYL9/MYL12B/RPS27A/ARPC2/RBX1/CYCS/VDAC1/BCL2/RRAGA/ARPC3/MYL5/RHOA/PLCE1/CAPN1/CAPNS1/ARF1/ARPC1B/UBE2D2/WIPI2/PYCARD/ACTN1/UBE2N/ILK/RPS6KB2	0.815508760081028
Human Diseases	Cancer: specific types	hsa05218	Melanoma	8/760	73/9376	1.3519826964672	IGF1/MAP2K2/CDK4/CCND1/PDGFRB/FGF1/PDGFD/BAD	0.89662495652343
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	7/760	63/9376	1.37076023391813	PTGDS/GPX4/PTGES2/CBR1/EPHX2/PTGR1/CBR3	0.876916435639638
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	7/760	63/9376	1.37076023391813	WNT4/PTCH1/HHIP/PTCH2/GLI2/GLI1/SMO	0.876916435639638
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	11/760	108/9376	1.25653021442495	RAN/SAP18/SUMO2/MAGOH/SEC13/RBM8A/UBE2I/SUMO1/ALYREF/SNUPN/THOC7	0.79633715372956
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	4/760	32/9376	1.54210526315789	LDHB/ECHS1/SUCLG1/SUCLG2	0.91228763222167
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	4/760	32/9376	1.54210526315789	BOK/CYCS/BCL2/BBC3	0.91228763222167
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	8/760	75/9376	1.3159298245614	IGF1/SIVA1/CDK4/CCND1/CYCS/BCL2/CCNB1/BBC3	0.815823150413039
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	3/760	22/9376	1.6822966507177	ALDH2/ASPA/CNDP2	0.951536574877589
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	4/760	33/9376	1.49537480063796	IDH3G/PDHA1/PDHB/ACO2	0.846617605192057
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	10/760	99/9376	1.2461456671983	GNAS/IGF1/MAP2K2/CDK4/CCND1/PRKACA/BCL2/NOTCH1/BAD/RPS6KB2	0.731215861734944
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	5/760	44/9376	1.40191387559809	GNAS/DYNLL1/CREB3L1/PRKACA/ARHGDIA	0.793618096603503
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	3/760	23/9376	1.6091533180778	SSBP1/POLD2/RPA2	0.868669662025221
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3/760	23/9376	1.6091533180778	MDH1/CA4/ATP1A2	0.868669662025221
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	15/760	157/9376	1.17867918203151	CACNA1D/HLA-B/CALM1/SLC25A6/SLC25A5/MAP2K2/CDK4/CCND1/VDAC2/VDAC1/PPP1CA/EIF4EBP1/CAPN1/CALM3/CCNB1	0.670535018331922
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	23/760	250/9376	1.13498947368421	HLA-B/BIN1/CLTB/PSD/ARPC2/AP2M1/ARF4/AP2S1/ACAP1/CLTA/SNF8/VPS28/AP2A1/ARPC3/CHMP2A/ASAP1/RHOA/VPS29/VPS25/ARF1/ARPC1B/CAPZB/SH3GL1	0.64249427968625
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	9/760	89/9376	1.24754583086931	GNAS/GNAI2/HTR2B/MAP2K2/PDGFRB/PRKACA/TUBA1B/GUCY1A2/PDGFD	0.69687115121629
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	3/760	24/9376	1.54210526315789	B4GALT7/NDST1/B3GALT6	0.78972626963934
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	5/760	46/9376	1.34096109839817	HMBS/UROS/MMAB/FXN/HMOX2	0.688466027238433
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	10/760	103/9376	1.19775166070516	FUS/SAP18/SSU72/MAGOH/RBM8A/PPP1CA/PABPN1/SYMPK/CSTF3/ALYREF	0.599333027438756
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	7/760	69/9376	1.25156369183829	CACNA1D/GNAS/CALM1/CREB3L1/PRKACA/PPP1CA/CALM3	0.622884088802634
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	13/760	138/9376	1.16216628527841	SOCS1/CALM1/MAP2K2/SOCS2/PRKACA/PPP1CA/EIF4EBP1/ELK1/CALM3/PRKAG1/EXOC7/BAD/RPS6KB2	0.569968325992837
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	7/760	70/9376	1.23368421052632	ELOB/MAP2K2/RBX1/SLC2A1/FH/BAD/ELOC	0.582822694325652
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/760	15/9376	1.64491228070175	ST6GALNAC4/HEXA	0.742377401442739
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	5/760	48/9376	1.28508771929825	ECHS1/HSD17B10/ALDH2/HADHB/ACAA2	0.588090885848327
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	8/760	83/9376	1.18909321496512	POLR2L/POLR2F/IL33/POLR2E/POLR2H/PYCARD/POLR1C/POLR2K	0.513897627387024
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	5/760	49/9376	1.25886143931257	GALNT17/B4GALT2/GALNT2/LFNG/RFNG	0.539552864327072
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	9/760	97/9376	1.14465545306565	CACNA1D/GNAS/CALM1/GNAI2/PRKACA/GNG11/GUCY1A2/CALM3/GNG5	0.425314000261706
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	4/760	39/9376	1.26531713900135	GCSH/BHMT2/CHDH/TYMS	0.493098315392447
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	3/760	28/9376	1.3218045112782	B4GALT2/B3GALT1/ST3GAL4	0.506467265739463
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	3/760	28/9376	1.3218045112782	CBR1/PCBD1/QDPR	0.506467265739463
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	9/760	98/9376	1.13297529538131	BIN1/ARPC2/MARCKSL1/ARPC3/CFL1/ASAP1/ARPC1B/MYO10/RPS6KB2	0.393003489622494
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	15/760	170/9376	1.08854489164087	WNT4/GSTP1/IGF2/GSTM5/MAP2K2/CDK4/NQO1/CCND1/SMARCD3/GSTO1/ELK1/KEAP1/BAD/GSTM4/RPS6KB2	0.346012728711025
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	8/760	87/9376	1.13442226255293	MAP2K2/CCND1/CYCS/BCL2/RHOA/BAD/BBC3/RPS6KB2	0.374098472660355
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	7/760	76/9376	1.13628808864266	GNAS/CALM1/GNAI2/SLC26A7/PRKACA/CALM3/ATP1A2	0.35429319590743
Human Diseases	Cancer: specific types	hsa05214	Glioma	7/760	76/9376	1.13628808864266	IGF1/CALM1/MAP2K2/CDK4/CCND1/PDGFRB/CALM3	0.35429319590743
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	12/760	137/9376	1.0805993084902	CTSL/MAP2K2/CTSC/CYCS/BCL2/TUBA1B/TNFSF10/CTSD/CAPN1/CTSH/BAD/BBC3	0.282240091968318
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	2/760	18/9376	1.37076023391813	FUCA2/HEXA	0.467603193812954
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	12/760	138/9376	1.07276887871854	IGF1/CALM1/ANAPC11/RBX1/PRKACA/PPP1CA/ANAPC16/ANAPC13/CALM3/ANAPC15/CCNB1/MAD1L1	0.25576189228465
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	7/760	78/9376	1.10715249662618	CLTB/ARPC2/CLTA/ARPC3/RHOA/ARPC1B/ILK	0.282224306193713
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	7/760	78/9376	1.10715249662618	CALM1/GNAI2/CFL1/RHOA/CALM3/PYCARD/IRF8	0.282224306193713
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	28/760	333/9376	1.03733206891102	WNT4/GNAS/HLA-B/ITGA6/CREB3L1/PKM/ATP6V0D1/MAP2K2/CDK4/CCND1/BCAP31/PDGFRB/LLGL1/PRKACA/LFNG/HEYL/EIF4EBP1/ISG15/TCIRG1/LAMB2/NOTCH1/ATP6V1G1/ATP6V1F/ATP6V0B/BAD/ATP6V0E2/RFNG/RPS6KB2	0.206009619203059
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	21/760	248/9376	1.0446519524618	GAPDH/TXN/DYNLL1/RPS3/MYL9/MYL12B/TXN2/MAP2K2/ARPC2/DCTN3/CYCS/BCL2/ARPC3/MYL5/TUBA1B/TNFSF10/RHOA/ARF1/ARPC1B/PYCARD/EXOC7	0.211649899995452
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	19/760	224/9376	1.04642857142857	RAN/HLA-B/CREB3L1/ANAPC11/SLC25A6/SLC25A5/MAP2K2/CDK4/CCND1/RANBP1/VDAC2/VDAC1/PRKACA/SLC2A1/ANAPC16/ANAPC13/ELK1/ANAPC15/MAD1L1	0.208877140586612
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	12/760	139/9376	1.06505111700114	KRT19/GNAS/CALM1/CREB3L1/GNAI2/MAP2K2/KRT17/KRT10/PRKACA/BCL2/CTSD/CALM3	0.229475474105117
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	10/760	115/9376	1.07276887871854	GNAS/CREB3L1/GNAI2/NACA/WNK2/PRKACA/BCL2/MAFB/RHOA/PTHLH	0.233187491355547
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7/760	79/9376	1.09313790806129	GSTP1/GSTM5/CBR1/AKR7A2/GSTO1/CBR3/GSTM4	0.246892671238849
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/760	19/9376	1.29861495844875	HYAL2/HEXA	0.386954261501622
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	12/760	140/9376	1.05744360902256	CALM1/GNAI2/MAP2K2/CCND1/ACTA2/PRKACA/GNG11/CALM3/PRKAG1/SLC8A1/GNG5/RPS6KB2	0.203377714486297
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	3/760	31/9376	1.19388794567063	ALDH2/AKR1A1/HSD17B14	0.321130527270828
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	3/760	31/9376	1.19388794567063	ECHS1/ALDH2/CNDP2	0.321130527270828
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	18/760	214/9376	1.03767830791933	HLA-B/CALM1/ELOB/GNAI2/MAP2K2/RBX1/CYCS/BCL2/AP1S1/CFL1/TAPBPL/GNG11/CALM3/GNG5/BAD/CCNB1/ELOC/RPS6KB2	0.165593285565866
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	17/760	203/9376	1.03313456053928	IGF1/ITGA6/MYL9/MYL12B/CCND1/PDGFRB/BCL2/PPP1CA/PGF/MYL5/LAMB2/RHOA/ELK1/ACTN1/PDGFD/ILK/BAD	0.141746755311162
NA	NA	hsa04518	Integrin signaling	13/760	154/9376	1.04142173615858	FREM1/IGF1/ITGA6/CCND1/PDGFRB/FERMT1/PGF/LAMB2/ITGAE/ACTN1/PDGFD/ILK/ICAM3	0.153927313156854
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	3/760	32/9376	1.15657894736842	B4GALT2/PGM1/PFKP	0.263500553966939
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	17/760	204/9376	1.0280701754386	WNT4/IGF2/CD63/LUM/IGF1/HOXD10/CTSL/MAP2K2/CCND1/PTCH1/PRKACA/PPP1CA/RHOA/ELK1/PLCE1/SMO/RPS6KB2	0.120383724837324
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/760	20/9376	1.23368421052632	SQLE/EBP	0.310698280412981
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	9/760	106/9376	1.04746772591857	GSTP1/IGF1/CREB3L1/MAP2K2/CCND1/PDGFRB/BCL2/PDGFD/BAD	0.145965789561325
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	7/760	83/9376	1.04045656309448	ECH1/SOD1/PRDX1/PRDX5/EPHX2/PMVK/DHRS4	0.109948586945983
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/760	21/9376	1.1749373433584	B4GALT7/B3GALT6	0.238347097476884
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/760	21/9376	1.1749373433584	ALDH2/PPCS	0.238347097476884
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	6/760	71/9376	1.04255003706449	ATP6V0D1/TCIRG1/ATP6V1G1/ATP6V1F/ATP6V0B/ATP6V0E2	0.106883463281849
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	15/760	183/9376	1.01121656600518	RAN/NHP2/SNU13/RPP25/POP7/IMP3/EIF6/NOP56/POP5/NOP10/IMP4/GNL3/PWP2/RPP40/NOB1	0.045508908601623
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	5/760	59/9376	1.04549509366637	MAP2K2/CCND1/ELK1/ILK/BAD	0.104109919524737
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	10/760	122/9376	1.01121656600518	WNT4/MAP2K2/CCND1/PRKACA/SLC2A1/NOTCH1/PLCE1/ATP1A2/PFKP/BAD	0.0370351982086363
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	4/760	47/9376	1.04994400895857	CACNA1D/SOCS1/PKM/SOCS2	0.101942286767755
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	9/760	110/9376	1.00937799043062	IGF1/GNAI2/ANAPC11/PRKACA/ANAPC16/ANAPC13/ANAPC15/CCNB1/MAD1L1	0.0293832323322148
Organismal Systems	Nervous system	hsa04730	Long-term depression	5/760	60/9376	1.0280701754386	GNAS/IGF1/GNAI2/MAP2K2/GUCY1A2	0.0647806947627773
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	8/760	98/9376	1.00708915145005	CACNA1D/GNAS/CALM1/CREB3L1/ATP2B1/PRKACA/CALM3/ATP1A2	0.0209517207714739
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	7/760	86/9376	1.00416156670747	CACNA1D/GNAS/CREB3L1/KCNMB1/PRKACA/SLC2A1/ATP1A2	0.0115143073629037
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	8/760	99/9376	0.996916533758639	GNAS/IGF1/CALM1/ASIC2/HTR2B/PRKACA/PPP1CA/CALM3	-0.00915993952065363
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/760	23/9376	1.07276887871854	ASS1/ASL	0.103770455493621
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	3/760	36/9376	1.0280701754386	GALNT17/GALNT2/ST6GALNAC4	0.0501143992337252
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	3/760	36/9376	1.0280701754386	SSBP1/POLD2/RPA2	0.0501143992337252
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	4/760	49/9376	1.00708915145005	GNAS/CREB3L1/GNAI2/PRKACA	0.0147761365334385
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	5/760	62/9376	0.99490662139219	IGF1/SOD1/PRKACA/PRKAG1/RPS6KB2	-0.0119501478106304
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	6/760	75/9376	0.986947368421053	GNAS/CREB3L1/GPX7/PRKACA/DUOX1/ATP1A2	-0.0337057099015603
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	18/760	227/9376	0.978251796893114	GNAS/HLA-B/CALM1/CREB3L1/GNAI2/MAP2K2/CDK4/CCND1/CYCS/PRKACA/EIF4EBP1/RHOA/ELK1/TAPBPL/GNG11/CALM3/GNG5/RPS6KB2	-0.0985119882002272
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	8/760	101/9376	0.977175612298072	WNT4/GNAS/CALM1/CREB3L1/GNAI2/MAP2K2/PRKACA/CALM3	-0.0684924107857212
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	3/760	37/9376	1.00028449502134	MIF/FAH/GSTZ1	0.000514949847861347
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	12/760	154/9376	0.961312371838688	CACNA1D/GNAS/CALM1/CREB3L1/GNAI2/ATP2B1/PRKACA/BCL2/PPP1CA/CALM3/SLC8A1/ATP1A2	-0.143767094466633
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	9/760	116/9376	0.957168784029038	CYBA/MYL9/MYL12B/GNAI2/MYL5/RHOA/CD99/ACTN1/THY1	-0.137855308535527
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/760	38/9376	0.973961218836565	NAPRT/QPRT/NT5C	-0.0477666852239407
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/760	38/9376	0.973961218836565	HSD11B2/IGF1/ATP1A2	-0.0477666852239407
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	9/760	117/9376	0.948987854251012	BCL7C/ZNHIT1/RUVBL2/SMARCD3/DMAP1/CDK2AP2/RUVBL1/CDK2AP1/BRD9	-0.164901296376715
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	4/760	52/9376	0.948987854251012	GNAS/IGF1/PRKACA/ACOT2	-0.109550337647247
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	8/760	105/9376	0.939949874686717	CACNA1D/GNAS/IGF1/ITGA6/PRKACA/EMD/SLC8A1/SSPN	-0.183774337675363
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	7/760	93/9376	0.928579513299377	CACNA1D/GNAS/CALM1/MAP2K2/PRKACA/ELK1/CALM3	-0.205569980008322
Organismal Systems	Digestive system	hsa04970	Salivary secretion	7/760	93/9376	0.928579513299377	GNAS/CALM1/ATP2B1/PRKACA/GUCY1A2/CALM3/ATP1A2	-0.205569980008322
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	7/760	93/9376	0.928579513299377	ITGA6/CDK4/CCND1/CYCS/BCL2/LAMB2/CKS2	-0.205569980008322
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	5/760	67/9376	0.920659858601728	CALM1/MAP2K2/PRKACA/PPP1CA/CALM3	-0.193561262232005
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	10/760	133/9376	0.927582113177681	CACNA1D/GNAS/CALM1/CREB3L1/GNAI2/PRKACA/PPP1CA/GNG11/CALM3/GNG5	-0.249807101880919
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	9/760	120/9376	0.925263157894737	CALM1/BEX3/MAP2K2/BCL2/RHOA/CALM3/MAGED1/ARHGDIA/BAD	-0.244710882191887
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	4/760	54/9376	0.913840155945419	ERCC1/CENPX/RPA2/TELO2	-0.188576175695717
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	5/760	68/9376	0.907120743034056	MAP2K2/CCND1/EIF4EBP1/BAD/RPS6KB2	-0.228288792321348
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	3/760	41/9376	0.902695763799743	MAP2K2/CDK4/CCND1	-0.185441146796754
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	7/760	95/9376	0.909030470914127	ATP6V0D1/CTSL/TCIRG1/ATP6V1G1/ATP6V1F/ATP6V0B/ATP6V0E2	-0.264667095902995
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	9/760	122/9376	0.910094909404659	CACNA1D/GNAS/SOCS1/IGF1/CREB3L1/GNAI2/MAP2K2/SOCS2/PRKACA	-0.296851357949221
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/760	42/9376	0.881203007518797	ECHS1/ALDH2/HAAO	-0.229158400418623
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	3/760	42/9376	0.881203007518797	GPX4/VDAC2/GSS	-0.229158400418623
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	5/760	70/9376	0.881203007518797	GSTP1/GSTM5/CBR1/GSTO1/GSTM4	-0.296286955287815
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/760	29/9376	0.850816696914701	CALM1/CALM3	-0.238958611174927
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/760	14/9376	0.881203007518797	B4GALT2	-0.132106666698289
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	7/760	99/9376	0.872301967038809	CACNA1D/IGF1/ITGA6/EMD/PRKAG1/SLC8A1/SSPN	-0.379347840148452
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	3/760	44/9376	0.841148325358852	HLA-B/PTPRN2/CPE	-0.313668104848051
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	17/760	232/9376	0.903992740471869	TMSB4X/ITGA6/MYL9/MYL12B/MAP2K2/ARPC2/PDGFRB/PPP1CA/ARPC3/MYL5/CFL1/FGF1/RHOA/ITGAE/ARPC1B/ACTN1/PDGFD	-0.439763870291266
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	6/760	86/9376	0.860709914320685	NRG2/MAP2K2/EIF4EBP1/ELK1/BAD/RPS6KB2	-0.385390640558371
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	13/760	180/9376	0.890994152046783	SRSF2/HLA-B/SRSF9/SRSF3/CYCS/EIF2B2/BCL2/PPP1CA/EIF4EBP1/EIF2B1/TAPBPL/ALYREF/BAD	-0.438557111796934
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	2/760	30/9376	0.822456140350877	DPM2/GPAA1	-0.28926306594188
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/760	15/9376	0.822456140350877	AK1	-0.204375933150177
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	8/760	115/9376	0.858215102974828	CACNA1D/GNAS/GNAI2/HTR2B/PRKACA/GNG11/HTR1E/GNG5	-0.45434896114433
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	12/760	169/9376	0.875988788539396	DDIT4/RPS27A/CTSL/MAP2K2/PRKACA/BCL2/RRAGA/CTSD/MLST8/WIPI2/BAD/RPS6KB2	-0.483153155238963
NA	NA	hsa04981	Folate transport and metabolism	2/760	31/9376	0.795925297113752	BHMT2/TYMS	-0.338002533957562
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	6/760	89/9376	0.831697220579539	CACNA1D/GNAI2/SLC38A5/PRKACA/GNG11/GNG5	-0.473792474047196
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/760	16/9376	0.771052631578947	MIF	-0.272205760826736
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/760	16/9376	0.771052631578947	HEXA	-0.272205760826736
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	17/760	238/9376	0.881203007518797	IGF2/IGF1/CALM1/MAP2K2/PDGFRB/PRKACA/PGF/RASA4/FGF1/RHOA/ELK1/PLCE1/GNG11/CALM3/GNG5/PDGFD/BAD	-0.551325318269293
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	11/760	158/9376	0.858894070619587	ANAPC11/CDK4/CCND1/RBX1/ANAPC16/ANAPC13/CDKN1C/ANAPC15/MAD2L1BP/CCNB1/MAD1L1	-0.531245230879653
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	2/760	32/9376	0.771052631578947	MLST8/WIPI2	-0.385286524287793
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	6/760	90/9376	0.822456140350877	IGF1/CREB3L1/PRKACA/EIF4EBP1/PRKAG1/RPS6KB2	-0.502634345547335
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	5/760	76/9376	0.811634349030471	PLTP/ANGPTL4/FADS2/DBI/ILK	-0.489673522798887
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	14/760	200/9376	0.863578947368421	GAPDH/RPS3/ARPC2/TMBIM6/CYCS/ARPC3/TUBA1B/TNFSF10/RHOA/ARF1/ARPC1B/PYCARD/MYO10/MYO5B	-0.579174297843399
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	3/760	48/9376	0.771052631578947	CACNA1D/SLC37A4/ATP1A2	-0.472282219096657
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	18/760	254/9376	0.874264401160381	CACNA1D/GNAS/CALM1/SLC25A6/HTR2B/ATP2B1/SLC25A5/PDGFRB/VDAC2/VDAC1/PRKACA/EDNRA/FGF1/ORAI2/PLCE1/CALM3/SLC8A1/PDGFD	-0.603350487667944
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/760	17/9376	0.725696594427245	CDO1	-0.336186698169535
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/760	17/9376	0.725696594427245	CA4	-0.336186698169535
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	6/760	93/9376	0.795925297113752	MYL9/MYL12B/MYL5/RHOA/SNAI1/ACTN1	-0.587389340657692
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	15/760	217/9376	0.852777104050449	CACNA1D/GNAS/CREB3L1/GNAI2/GSTM5/MAP2K2/CCND1/PRKACA/GSTO1/EPHX2/BCL2/EIF4EBP1/BAD/GSTM4/RPS6KB2	-0.651659578066483
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/760	18/9376	0.685380116959064	HSD17B8	-0.396798924718248
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	4/760	65/9376	0.75919028340081	CACNA1D/GNAS/CREB3L1/PRKACA	-0.578591582038196
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	7/760	109/9376	0.792274263640753	CREB3L1/PPP1CA/SLC2A1/PTPA/PPARGC1B/PRKAG1/RPS6KB2	-0.647848658503558
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	16/760	233/9376	0.8471651231082	PDLIM2/ITGA6/MYL9/ENO1/PDLIM4/COL5A1/AMPD2/MYL5/CSRP1/FHL2/FLNC/EMD/DAAM1/ATP1A2/CAPZB/SSPN	-0.70160982378824
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	7/760	110/9376	0.785071770334928	RBX1/BMP7/ID3/EMP3/ID1/RHOA/RPS6KB2	-0.673415712430144
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/760	36/9376	0.685380116959064	AKR1A1/DCXR	-0.561698891411338
Cellular Processes	Cell motility	hsa04814	Motor proteins	13/760	194/9376	0.826695604991861	DYNLL1/MYL9/MYL12B/DCTN3/ACTA2/MYL6/MYL6B/MYL5/TUBA1B/KIF9/CAPZB/MYO10/MYO5B	-0.724404912066154
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	5/760	82/9376	0.752246469833119	HLA-B/PSME2/CTSL/TAPBPL/PSME1	-0.669214022801052
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	12/760	181/9376	0.817912183774353	CALM1/ATP6V0D1/CYCS/MRC2/BCL2/CTSD/TCIRG1/RHOA/CALM3/LSP1/ATP6V0B/BAD	-0.734655775749397
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	11/760	168/9376	0.807769423558897	SLC25A6/SLC25A5/IL33/PPIA/VDAC2/VDAC1/BCL2/CHMP2A/TNFSF10/CAPN1/PYCARD	-0.746679181970126
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	7/760	112/9376	0.771052631578947	SOCS1/ITGA6/GNAI2/CYCS/BCL2/LAMB2/BAD	-0.723910679051376
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	2/760	37/9376	0.666856330014225	MAP2K2/CCND1	-0.60300627184559
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	10/760	155/9376	0.795925297113752	WNT4/CACNA1D/GNAS/CREB3L1/GNAI2/MAP2K2/CDK4/CCND1/PRKACA/FH	-0.76086148427818
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	4/760	70/9376	0.704962406015038	HLA-B/CCND1/CYCS/SSPN	-0.735841780094549
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	7/760	115/9376	0.750938215102975	CACNA1D/CREB3L1/GNAI2/PRKACA/BCL2/GNG11/GNG5	-0.798117187394268
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	5/760	86/9376	0.717258261933905	CACNA1D/ITGA6/EMD/SLC8A1/SSPN	-0.782295588479646
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	8/760	130/9376	0.75919028340081	GNAS/CREB3L1/GNAI2/MAP2K2/ACTA2/PRKACA/GNG11/GNG5	-0.821123208576997
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	4/760	71/9376	0.695033358042995	SOCS1/MAP2K2/CCND1/SOCS2	-0.766060222894644
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	3/760	56/9376	0.660902255639098	CYCS/ARF1/PYCARD	-0.755875984788437
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	6/760	103/9376	0.718650996423097	GNAS/PRDX1/PRKACA/LAMB2/ACTN1/SERPINB6	-0.852694482965838
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4/760	73/9376	0.675991348233598	GSTP1/GSTM5/GSTO1/GSTM4	-0.825365127942707
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	4/760	73/9376	0.675991348233598	RAN/PPIA/PIN1/NELFE	-0.825365127942707
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	4/760	73/9376	0.675991348233598	MAP2K2/CDK4/CCND1/BAD	-0.825365127942707
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/760	23/9376	0.536384439359268	B4GALT2	-0.661128751037978
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/760	23/9376	0.536384439359268	PMVK	-0.661128751037978
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	9/760	148/9376	0.750213371266003	WNT4/IGF1/MAP2K2/CDK4/CCND1/HEYL/FGF1/NOTCH1/RPS6KB2	-0.90967412251523
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	3/760	59/9376	0.627297056199822	GNAS/GNAI2/PRKACA	-0.852884791714411
Human Diseases	Substance dependence	hsa05032	Morphine addiction	5/760	91/9376	0.677848467322152	GNAS/GNAI2/PRKACA/GNG11/GNG5	-0.917127114157497
Human Diseases	Infectious disease: viral	hsa05162	Measles	8/760	136/9376	0.725696594427245	RACK1/CDK4/CCND1/CYCS/BCL2/EIF3H/BAD/BBC3	-0.956983075709066
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	7/760	122/9376	0.707851596203624	IGF1/CREB3L1/CCND1/EIF4EBP1/PRKAG1/PFKP/RPS6KB2	-0.964624470264935
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	4/760	77/9376	0.640874914559125	CDK4/CCND1/BAD/RPS6KB2	-0.939750510376757
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	4/760	77/9376	0.640874914559125	MAP2K2/CDK4/CCND1/BAD	-0.939750510376757
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	2/760	44/9376	0.560765550239234	POLD2/NTHL1	-0.867311205573828
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	13/760	212/9376	0.756504468718967	GNAS/IGF1/CALM1/GNAI2/MAP2K2/PDGFRB/PGF/ID1/FGF1/RHOA/PLCE1/CALM3/PDGFD	-1.06501561341148
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/760	26/9376	0.474493927125506	FADS2	-0.796889669638054
Organismal Systems	Immune system	hsa04611	Platelet activation	7/760	126/9376	0.685380116959064	GNAS/MYL12B/GNAI2/PRKACA/PPP1CA/RHOA/GUCY1A2	-1.05594223441462
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	3/760	63/9376	0.587468671679198	ECHS1/PLOD1/ALDH2	-0.975712789361995
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/760	27/9376	0.45692007797271	ECHS1	-0.839271814568708
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	9/760	157/9376	0.707207509218907	WNT4/CCND1/BMP7/LLGL1/PPP1CA/ID1/FGF1/GLI2/BBC3	-1.09877164167186
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	11/760	187/9376	0.725696594427245	TXN/TXNIP/CYBA/TXN2/CARD16/VDAC2/VDAC1/BCL2/TRIP6/RHOA/PYCARD	-1.12527188015402
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	10/760	173/9376	0.713112260419836	SLC25A6/SLC25A5/IL33/MAP2K2/CDK4/CYCS/VDAC1/PABPN1/TNFSF10/PYCARD	-1.13112322159116
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	8/760	144/9376	0.685380116959064	WNT4/IGF1/MAP2K2/ID3/MEIS1/ID1/PCGF2/DLX5	-1.12994967769632
NA	NA	hsa03272	Virion - Hepatitis viruses	2/760	48/9376	0.514035087719298	CD63/CD81	-1.00246877156915
NA	NA	hsa04081	Hormone signaling	13/760	219/9376	0.732323960586397	RAMP1/IGF2/GNAS/IGF1/GNAI2/PENK/PRKACA/ADRA2C/RHOA/GNG11/GNG5/PTHLH/ADRA2A	-1.19040443790483
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	5/760	99/9376	0.623072833599149	MAP2K2/PDGFRB/EIF4EBP1/PDGFD/RPS6KB2	-1.11972364140405
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	12/760	205/9376	0.722156611039795	HLA-B/CREB3L1/PKM/ATP6V0D1/CDK4/CCND1/RANBP1/PRKACA/RHOA/ACTN1/BAD/MAD1L1	-1.19456074909784
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	6/760	116/9376	0.638112522686025	CACNA1D/GNAS/GNAI2/PRKACA/GNG11/GNG5	-1.16476053059254
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	10/760	178/9376	0.693081017149616	WNT4/SFRP4/CCND1/RBX1/PRICKLE1/PRKACA/CBY1/RHOA/RUVBL1/DAAM1	-1.22779719815566
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	5/760	101/9376	0.610734757686295	F3/CDK4/CCND1/BCL2/PLCE1	-1.16812399216744
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/760	30/9376	0.411228070175439	TYMS	-0.959255779941649
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	7/760	133/9376	0.649307479224377	IGF1/PRMT1/MAP2K2/CCND1/TNFSF10/PRKAG1/CCNB1	-1.20972160484628
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/760	51/9376	0.483797729618163	PLD3/PLA2G7	-1.09779226730697
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	4/760	88/9376	0.560765550239234	F3/F13A1/CLU/F10	-1.22946513332415
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	5/760	105/9376	0.587468671679198	FIS1/RPS27A/MTX1/TOMM7/TOMM40	-1.26248981558283
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	5/760	105/9376	0.587468671679198	CALM1/RHOA/CALM3/PYCARD/LSP1	-1.26248981558283
NA	NA	hsa04082	Neuroactive ligand signaling	11/760	199/9376	0.681935995768315	GNAS/GNAI2/HTR2B/PENK/PRKACA/ADRA2C/SLC6A9/GNG11/HTR1E/GNG5/ADRA2A	-1.34688427865206
Organismal Systems	Digestive system	hsa04976	Bile secretion	4/760	90/9376	0.548304093567251	GNAS/PRKACA/SLC2A1/ATP1A2	-1.27877064723571
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/760	55/9376	0.448612440191388	DEGS1/HEXA	-1.2179981915038
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	6/760	125/9376	0.592168421052632	GNAI2/MAP2K2/BCL2/CTSD/RHOA/DEGS1	-1.36326757729065
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/760	36/9376	0.342690058479532	PGM1	-1.1735121820564
Human Diseases	Substance dependence	hsa05034	Alcoholism	10/760	191/9376	0.645907963626343	GNAS/CALM1/CREB3L1/GNAI2/PRKACA/PPP1CA/GNG11/CALM3/GNG5/SLC29A1	-1.46836103698665
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	3/760	78/9376	0.474493927125506	TPI1/ITPK1/PLCE1	-1.38410761752937
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	3/760	78/9376	0.474493927125506	CYBA/MARCKSL1/ELK1	-1.38410761752937
NA	NA	hsa04517	IgSF CAM signaling	17/760	299/9376	0.701425805315965	DYNLL1/MYL9/MYL12B/MAP2K2/ARPC2/MYL6/MYL6B/NLGN3/ARPC3/UNC5B/TUBA1B/RHOA/PLXNA2/ARPC1B/ACTN1/SRGAP3/ICAM3	-1.55831871058062
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	2/760	60/9376	0.411228070175439	MAP2K2/BAD	-1.35877507264925
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	10/760	196/9376	0.629430719656284	HLA-B/CALM1/RPS27A/MAP2K2/CDK4/CCND1/CYCS/GNG11/CALM3/GNG5	-1.55709710899494
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	4/760	98/9376	0.503544575725027	CALM1/ITPK1/PLCE1/CALM3	-1.46725535463261
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/760	39/9376	0.316329284750337	HLA-B	-1.27061854820861
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	21/760	362/9376	0.715673160802559	IGF2/IGF1/ITGA6/DDIT4/CREB3L1/MAP2K2/CDK4/CCND1/PDGFRB/BCL2/PGF/EIF4EBP1/FGF1/LAMB2/MLST8/GNG11/GNG5/PDGFD/BAD/THEM4/RPS6KB2	-1.63852455717741
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	3/760	83/9376	0.445909955611921	CBX6/PCGF2/UBE2D2	-1.50584757481818
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	4/760	102/9376	0.483797729618163	GNAS/ATP2B1/RHOA/ATP1A2	-1.55677568439208
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	4/760	103/9376	0.479100664282064	COL15A1/COL5A1/SLC8A1/ATP1A2	-1.57870823816814
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	6/760	138/9376	0.536384439359268	MAP2K2/ARPC2/ARPC3/RHOA/ARPC1B/PYCARD	-1.62947670996447
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	2/760	65/9376	0.379595141700405	ALDH2/AKR1A1	-1.49064179609168
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	2/760	65/9376	0.379595141700405	CACNA1D/MAP2K2	-1.49064179609168
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2/760	66/9376	0.37384370015949	HSD11B2/HSD17B8	-1.51607075717378
Organismal Systems	Sensory system	hsa04742	Taste transduction	3/760	86/9376	0.430354957160343	ASIC2/PRKACA/HTR1E	-1.57610548432219
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/760	44/9376	0.280382775119617	GTF2H5	-1.42095430629961
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/760	45/9376	0.274152046783626	HLA-B	-1.44953066682694
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/760	68/9376	0.362848297213622	ALDH1A2/DHRS4	-1.56606111532445
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	3/760	89/9376	0.415848610289769	FREM1/ITGA6/LAMB2	-1.64445609931068
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	2/760	70/9376	0.352481203007519	SLC2A1/PRKAG1	-1.61495142970802
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	2/760	72/9376	0.342690058479532	ISG15/PIN1	-1.6628044855932
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	10/760	216/9376	0.571150097465887	CALM1/CYBA/CYCS/MIB2/BCL2/TNFSF10/RHOA/CALM3/PYCARD/BAD	-1.89375609514915
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	6/760	149/9376	0.496785588131402	GNAS/MAP2K2/PDGFRB/RHOA/ARF1/PDGFD	-1.83888907971101
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	6/760	150/9376	0.493473684210526	WNT4/MAP2K2/CCND1/BCL2/FGF1/RPS6KB2	-1.85729336374041
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/760	50/9376	0.246736842105263	CCR10	-1.58607460798563
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	1/760	50/9376	0.246736842105263	CD81	-1.58607460798563
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	3/760	99/9376	0.37384370015949	KRT19/KRT17/KRT10	-1.86009944265965
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	6/760	156/9376	0.474493927125506	CD81/MAP2K2/CDK4/CCND1/CYCS/BAD	-1.96568610186455
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	1/760	54/9376	0.228460038986355	HLA-B	-1.68865272263269
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	3/760	100/9376	0.370105263157895	ITGA6/CD34/IL11RA	-1.88073323329231
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	6/760	157/9376	0.471471672812605	ANO4/MAP2K2/UQCRFS1/GAS6/ODC1/SLC2A1	-1.98342497167375
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	6/760	160/9376	0.462631578947368	HLA-B/ITGA6/NLGN3/CD99/CD34/ICAM3	-2.03610649192158
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	5/760	143/9376	0.431358115568642	SNRPD1/SNRPD3/SNRPB/SSB/ACTN1	-2.03504977242694
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	3/760	105/9376	0.352481203007519	UBE2I/BCL2/EDAR	-1.98163346752115
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	6/760	163/9376	0.4541168873103	CREB3L1/MAP2K2/CYCS/BCL2/ELK1/BAD	-2.08800971546892
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	6/760	168/9376	0.440601503759398	SOCS1/CCND1/SOCS2/PDGFRB/BCL2/IL11RA	-2.1728656247162
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	2/760	90/9376	0.274152046783626	MAP2K2/RPS6KB2	-2.05490694892408
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	2/760	91/9376	0.271139386928861	CD81/MAP2K2	-2.07497951393407
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/760	66/9376	0.186921850079745	MAF	-1.9686522465797
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	7/760	193/9376	0.447450231797109	GNAI2/PRKACA/RHOA/GNG11/GNG5/BAD/CCR10	-2.30354845795264
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	2/760	93/9376	0.265308432371251	MAF/NOTCH1	-2.11466678325518
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	1/760	69/9376	0.178794813119756	MAP2K2	-2.03334448151885
NA	NA	hsa04382	Cornified envelope formation	8/760	217/9376	0.454814455493573	S100A13/KRT19/S100A11/ITGA6/KRT17/KRT10/EPHX2/CAPN1	-2.41318022994702
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	3/760	122/9376	0.303364969801553	MAP2K2/CDK4/RHOA	-2.30017069489636
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	4/760	144/9376	0.342690058479532	CCND1/ALDH2/PRKAG1/ACADVL	-2.36071270953655
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	2/760	100/9376	0.246736842105263	TNFSF10/CCR10	-2.24908539729943
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	2/760	103/9376	0.239550332141032	GNAS/GNAI2	-2.30472199337043
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	2/760	104/9376	0.237246963562753	PEMT/PLD3	-2.32302290821087
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	6/760	195/9376	0.379595141700405	CYBA/SLC25A6/SLC25A5/MAP2K2/VDAC2/VDAC1	-2.60008227837579
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	3/760	133/9376	0.278274633953304	HLA-B/MAP2K2/TNFSF10	-2.48960760880011
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	3/760	142/9376	0.260637509266123	SOCS1/CYBA/FHL2	-2.6366120979906
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	5/760	201/9376	0.306886619533909	IGF1/FUS/MEIS1/MAF/NUPR1	-2.95011444705517
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	10/760	300/9376	0.411228070175439	IGF2/CACNA1D/IGF1/MAP2K2/PDGFRB/PRKACA/PGF/FGF1/ELK1/PDGFD	-3.07822293335373
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	11/760	323/9376	0.420140133615773	SOCS1/DDIT4/HOXD10/MAP2K2/CCND1/PDGFRB/UBE2I/FSCN1/BCL2/RHOA/NOTCH1	-3.14968876501419
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	1/760	109/9376	0.113182037662965	MAP2K2	-2.76578067458771
NA	NA	hsa04519	Cadherin signaling	15/760	404/9376	0.458051068264721	KRT19/WNT4/MAP2K2/ARPC2/KRT17/KRT10/PDGFRB/PRICKLE1/PPP1CA/ARPC3/PSENEN/RHOA/ARPC1B/DAAM1/ACTN1	-3.30707469251391
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	1/760	119/9376	0.103670942061035	CREB3L1	-2.92243872468922
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	7/760	298/9376	0.289791593076651	IL33/BMP7/GDF11/TNFSF10/EDAR/IL11RA/CCR10	-3.70031282452541
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	8/760	370/9376	0.26674253200569	EDN3/HTR2B/PENK/PGRMC1/EDNRA/ADRA2C/HTR1E/ADRA2A	-4.27396513174894
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	5/760	449/9376	0.137381315203376	CALM1/PRKACA/OR2C3/CALM3/SLC8A1	-5.56325354421777