ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003735 structural constituent of ribosome 91/1315 175/18639 0.52 7.37055513307985 7.19673660596964e-58 7.52058975323828e-55 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 42/1315 68/18639 0.617647058823529 8.75461865354507 1.6961465313923e-31 8.86236562652479e-29 GO:0009055 electron transfer activity 52/1315 116/18639 0.448275862068966 6.35392683886194 2.04429175426525e-29 7.12094961069063e-27 GO:0022853 active monoatomic ion transmembrane transporter activity 50/1315 118/18639 0.423728813559322 6.00599342656441 6.25715870330588e-27 1.63468271123866e-24 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 34/1315 58/18639 0.586206896551724 8.30898125081946 1.15379454278725e-24 2.41143059442535e-22 GO:0003954 NADH dehydrogenase activity 29/1315 44/18639 0.659090909090909 9.34204977531974 2.46759247245341e-23 4.29772355618968e-21 GO:0008137 NADH dehydrogenase (ubiquinone) activity 28/1315 41/18639 0.682926829268293 9.67990355188723 3.14150892415894e-23 4.68982403678013e-21 GO:0015078 proton transmembrane transporter activity 55/1315 185/18639 0.297297297297297 4.21393484739492 1.01882156991307e-20 1.33083567569895e-18 GO:0016651 oxidoreductase activity, acting on NAD(P)H 37/1315 88/18639 0.420454545454545 5.95958347735914 3.92232378621311e-20 4.55425372954745e-18 GO:0015399 primary active transmembrane transporter activity 50/1315 166/18639 0.301204819277108 4.26932062852169 3.17510107765518e-19 3.31798062614966e-17 GO:0019843 rRNA binding 22/1315 65/18639 0.338461538461538 4.79740274934191 2.50647081593187e-10 2.38114727513528e-08 GO:0022804 active transmembrane transporter activity 69/1315 457/18639 0.150984682713348 2.14007870805634 1.43280915782922e-09 1.24773797494295e-07 GO:0016675 oxidoreductase activity, acting on a heme group of donors 10/1315 16/18639 0.625 8.85884030418251 1.59762449593708e-08 1.28424430634943e-06 GO:0043021 ribonucleoprotein complex binding 34/1315 177/18639 0.192090395480226 2.72271702004253 7.42436977523852e-08 5.54176172508876e-06 GO:0004129 cytochrome-c oxidase activity 9/1315 15/18639 0.6 8.50448669201521 1.42994609728477e-07 9.9619578110839e-06 GO:0016209 antioxidant activity 21/1315 86/18639 0.244186046511628 3.46112830488991 3.8284107500545e-07 2.50043077112934e-05 GO:0016859 cis-trans isomerase activity 14/1315 42/18639 0.333333333333333 4.72471482889734 5.72226233818244e-07 3.51750831964744e-05 GO:0016853 isomerase activity 32/1315 180/18639 0.177777777777778 2.51984790874525 1.08658336623907e-06 6.30822009844349e-05 GO:0043022 ribosome binding 23/1315 112/18639 0.205357142857143 2.9107618142314 2.84477124134291e-06 0.00015646241827386 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 12/1315 36/18639 0.333333333333333 4.72471482889734 3.68707032428876e-06 0.000175135840403716 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 12/1315 36/18639 0.333333333333333 4.72471482889734 3.68707032428876e-06 0.000175135840403716 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 12/1315 36/18639 0.333333333333333 4.72471482889734 3.68707032428876e-06 0.000175135840403716 GO:0004601 peroxidase activity 15/1315 57/18639 0.263157894736842 3.73003802281369 6.47029834704109e-06 0.000293976598811215 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 12/1315 39/18639 0.307692307692308 4.36127522667447 9.44936930273075e-06 0.000411441288389735 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 15/1315 59/18639 0.254237288135593 3.60359605593865 1.02377303021903e-05 0.000427937126631555 GO:0031386 protein tag activity 7/1315 15/18639 0.466666666666667 6.61460076045627 3.32787518320469e-05 0.00128801095053663 GO:0141047 molecular tag activity 7/1315 15/18639 0.466666666666667 6.61460076045627 3.32787518320469e-05 0.00128801095053663 GO:0070990 snRNP binding 6/1315 11/18639 0.545454545454545 7.73135153819564 4.13574065101355e-05 0.00154351749296756 GO:0008135 translation factor activity, RNA binding 17/1315 83/18639 0.204819277108434 2.90313802739475 5.66653698849842e-05 0.00204190729413133 GO:0180051 translation factor activity 17/1315 84/18639 0.202380952380952 2.86857686040196 6.64365224428043e-05 0.00231420553175768 GO:0016504 peptidase activator activity 13/1315 57/18639 0.228070175438596 3.23269961977186 0.000132732611116683 0.00447437350377205 GO:0003743 translation initiation factor activity 12/1315 51/18639 0.235294117647059 3.33509282039812 0.000174161985152958 0.0056874773276513 GO:0097001 ceramide binding 7/1315 19/18639 0.368421052631579 5.22205323193916 0.000202742987772128 0.00642019461278406 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 6/1315 15/18639 0.4 5.66965779467681 0.000350262310140496 0.0105800660090278 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 10/1315 40/18639 0.25 3.543536121673 0.000354356277814327 0.0105800660090278 GO:0016829 lyase activity 28/1315 200/18639 0.14 1.98438022813688 0.00039101774258391 0.011350376138894 GO:0061133 endopeptidase activator activity 7/1315 22/18639 0.318181818181818 4.50995506394746 0.000568906299067812 0.0160677589871855 GO:0004550 nucleoside diphosphate kinase activity 6/1315 17/18639 0.352941176470588 5.00263923059718 0.000766202982076342 0.0210705820070994 GO:0051540 metal cluster binding 14/1315 77/18639 0.181818181818182 2.57711717939855 0.000890374844163482 0.0238574797987395 GO:0016860 intramolecular oxidoreductase activity 11/1315 53/18639 0.207547169811321 2.94180357270966 0.00100388971496385 0.0262266188034306 GO:0016835 carbon-oxygen lyase activity 14/1315 79/18639 0.177215189873418 2.51187370650238 0.00115614227625511 0.0287160446041309 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 11/1315 54/18639 0.203703703703704 2.8873257287706 0.00118161714639008 0.0287160446041309 GO:0017069 snRNA binding 11/1315 54/18639 0.203703703703704 2.8873257287706 0.00118161714639008 0.0287160446041309 GO:0044389 ubiquitin-like protein ligase binding 38/1315 322/18639 0.118012422360248 1.67272512575869 0.00126797825070286 0.0299365700577607 GO:0033218 amide binding 31/1315 247/18639 0.125506072874494 1.77894121088037 0.00128913459578874 0.0299365700577607 GO:0031625 ubiquitin protein ligase binding 36/1315 302/18639 0.119205298013245 1.68963311761892 0.00140589801057056 0.0319383352401356 GO:0015036 disulfide oxidoreductase activity 9/1315 40/18639 0.225 3.1891825095057 0.00156492427886035 0.0347945930087035 GO:0050750 low-density lipoprotein particle receptor binding 7/1315 26/18639 0.269230769230769 3.81611582334016 0.00171085158537323 0.0372466647232296 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 6/1315 20/18639 0.3 4.2522433460076 0.00199808271349351 0.0417599287120144 GO:0016505 peptidase activator activity involved in apoptotic process 6/1315 20/18639 0.3 4.2522433460076 0.00199808271349351 0.0417599287120144 GO:0008320 protein transmembrane transporter activity 7/1315 27/18639 0.259259259259259 3.67477820025349 0.00217075401267018 0.0444791753576537 GO:0051536 iron-sulfur cluster binding 13/1315 76/18639 0.171052631578947 2.4245247148289 0.00237874888322778 0.0478037035187121 GO:0046625 sphingolipid binding 7/1315 28/18639 0.25 3.543536121673 0.00272050198185688 0.0526467513155637 GO:0051537 2 iron, 2 sulfur cluster binding 7/1315 28/18639 0.25 3.543536121673 0.00272050198185688 0.0526467513155637 GO:0055106 ubiquitin-protein transferase regulator activity 8/1315 36/18639 0.222222222222222 3.14980988593156 0.00306754175192187 0.0582832932865156 GO:0016836 hydro-lyase activity 11/1315 61/18639 0.180327868852459 2.555993268092 0.00328364080863268 0.0608393030565894 GO:0034062 5'-3' RNA polymerase activity 6/1315 22/18639 0.272727272727273 3.86567576909782 0.00340589010778204 0.0608393030565894 GO:0097747 RNA polymerase activity 6/1315 22/18639 0.272727272727273 3.86567576909782 0.00340589010778204 0.0608393030565894 GO:0001094 TFIID-class transcription factor complex binding 4/1315 10/18639 0.4 5.66965779467681 0.00366782401202405 0.0608393030565894 GO:0004090 carbonyl reductase (NADPH) activity 4/1315 10/18639 0.4 5.66965779467681 0.00366782401202405 0.0608393030565894 GO:0016868 intramolecular phosphotransferase activity 4/1315 10/18639 0.4 5.66965779467681 0.00366782401202405 0.0608393030565894 GO:0033204 ribonuclease P RNA binding 4/1315 10/18639 0.4 5.66965779467681 0.00366782401202405 0.0608393030565894 GO:0097177 mitochondrial ribosome binding 4/1315 10/18639 0.4 5.66965779467681 0.00366782401202405 0.0608393030565894 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 18/1315 128/18639 0.140625 1.99323906844106 0.00381418763215159 0.0621679379510615 GO:0005159 insulin-like growth factor receptor binding 5/1315 16/18639 0.3125 4.42942015209125 0.00392639608111967 0.0621679379510615 GO:0043023 ribosomal large subunit binding 5/1315 16/18639 0.3125 4.42942015209125 0.00392639608111967 0.0621679379510615 GO:0051082 unfolded protein binding 17/1315 121/18639 0.140495867768595 1.99140872953524 0.00489058580267098 0.0729169205779837 GO:0005504 fatty acid binding 9/1315 47/18639 0.191489361702128 2.71419788043039 0.00500255650327331 0.0729169205779837 GO:0070325 lipoprotein particle receptor binding 7/1315 31/18639 0.225806451612903 3.20061327118852 0.00501975567715879 0.0729169205779837 GO:0016776 phosphotransferase activity, phosphate group as acceptor 8/1315 39/18639 0.205128205128205 2.90751681778298 0.00516877225091085 0.0729169205779837 GO:0004549 tRNA-specific ribonuclease activity 5/1315 17/18639 0.294117647058824 4.16886602549765 0.00524314320572106 0.0729169205779837 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 5/1315 17/18639 0.294117647058824 4.16886602549765 0.00524314320572106 0.0729169205779837 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 18/1315 132/18639 0.136363636363636 1.93283788454891 0.00529721816438992 0.0729169205779837 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 17/1315 122/18639 0.139344262295082 1.975085707162 0.00531904536034061 0.0729169205779837 GO:0042625 ATPase-coupled ion transmembrane transporter activity 6/1315 24/18639 0.25 3.543536121673 0.00544260268428969 0.0729169205779837 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 6/1315 24/18639 0.25 3.543536121673 0.00544260268428969 0.0729169205779837 GO:0046961 proton-transporting ATPase activity, rotational mechanism 6/1315 24/18639 0.25 3.543536121673 0.00544260268428969 0.0729169205779837 GO:0048027 mRNA 5'-UTR binding 6/1315 24/18639 0.25 3.543536121673 0.00544260268428969 0.0729169205779837 GO:0022884 macromolecule transmembrane transporter activity 7/1315 32/18639 0.21875 3.10059410646388 0.00604139371309174 0.0789157053772609 GO:0030515 snoRNA binding 7/1315 32/18639 0.21875 3.10059410646388 0.00604139371309174 0.0789157053772609 GO:0000287 magnesium ion binding 27/1315 230/18639 0.117391304347826 1.66392130930732 0.00638672725469676 0.0823966664340508 GO:0031690 adrenergic receptor binding 5/1315 18/18639 0.277777777777778 3.93726235741445 0.00684391295596968 0.0861673378191363 GO:0070628 proteasome binding 5/1315 18/18639 0.277777777777778 3.93726235741445 0.00684391295596968 0.0861673378191363 GO:0140318 protein transporter activity 8/1315 41/18639 0.195121951219512 2.76568672911064 0.00708506643240376 0.088141600260261 GO:0045296 cadherin binding 36/1315 334/18639 0.107784431137725 1.52775210036201 0.00739590215782336 0.0909260912344166 GO:0004526 ribonuclease P activity 4/1315 12/18639 0.333333333333333 4.72471482889734 0.00771490911084248 0.0926675864463263 GO:0010853 cyclase activator activity 4/1315 12/18639 0.333333333333333 4.72471482889734 0.00771490911084248 0.0926675864463263 GO:0015035 protein-disulfide reductase activity 7/1315 34/18639 0.205882352941176 2.91820621784836 0.00853875048155436 0.101397661968458 GO:0016918 retinal binding 5/1315 19/18639 0.263157894736842 3.73003802281369 0.00875725446992077 0.101681454678524 GO:0070003 threonine-type peptidase activity 5/1315 19/18639 0.263157894736842 3.73003802281369 0.00875725446992077 0.101681454678524 GO:0031994 insulin-like growth factor I binding 4/1315 13/18639 0.307692307692308 4.36127522667447 0.0105293830263652 0.120914343544523 GO:0016248 channel inhibitor activity 8/1315 44/18639 0.181818181818182 2.57711717939855 0.0109036998074995 0.12252006772943 GO:0019205 nucleobase-containing compound kinase activity 8/1315 44/18639 0.181818181818182 2.57711717939855 0.0109036998074995 0.12252006772943 GO:0141110 transporter inhibitor activity 8/1315 45/18639 0.177777777777778 2.51984790874525 0.012462951144566 0.138550893043313 GO:0016530 metallochaperone activity 4/1315 14/18639 0.285714285714286 4.04975556762629 0.0139306715800781 0.150077853620429 GO:0032036 myosin heavy chain binding 4/1315 14/18639 0.285714285714286 4.04975556762629 0.0139306715800781 0.150077853620429 GO:1990825 sequence-specific mRNA binding 4/1315 14/18639 0.285714285714286 4.04975556762629 0.0139306715800781 0.150077853620429 GO:0051861 glycolipid binding 6/1315 29/18639 0.206896551724138 2.93258161793628 0.0142122107791324 0.151548574124422 GO:0005501 retinoid binding 7/1315 38/18639 0.184210526315789 2.61102661596958 0.0156810552086681 0.163867026930582 GO:0019840 isoprenoid binding 7/1315 38/18639 0.184210526315789 2.61102661596958 0.0156810552086681 0.163867026930582 GO:0008106 alcohol dehydrogenase (NADP+) activity 6/1315 30/18639 0.2 2.8348288973384 0.0167318731348588 0.173116905207203 GO:0055105 ubiquitin-protein transferase inhibitor activity 4/1315 15/18639 0.266666666666667 3.77977186311787 0.0179548753153597 0.183949457887754 GO:0019842 vitamin binding 18/1315 150/18639 0.12 1.70089733840304 0.0187663905592625 0.188012930118909 GO:0005178 integrin binding 19/1315 161/18639 0.118012422360248 1.67272512575869 0.0188762755000948 0.188012930118909 GO:0004857 enzyme inhibitor activity 41/1315 416/18639 0.0985576923076923 1.39697097104416 0.0188912513516607 0.188012930118909 GO:1901681 sulfur compound binding 29/1315 275/18639 0.105454545454545 1.49472796405116 0.0196958563685636 0.194171414199519 GO:0004602 glutathione peroxidase activity 5/1315 23/18639 0.217391304347826 3.08133575797653 0.0200513350230752 0.19582845887022 GO:0050997 quaternary ammonium group binding 7/1315 40/18639 0.175 2.4804752851711 0.0205071680157465 0.198425838670881 GO:0017070 U6 snRNA binding 4/1315 16/18639 0.25 3.543536121673 0.0226310350601064 0.213316378696158 GO:0019841 retinol binding 4/1315 16/18639 0.25 3.543536121673 0.0226310350601064 0.213316378696158 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 6/1315 32/18639 0.1875 2.65765209125475 0.0226584861581565 0.213316378696158 GO:0031406 carboxylic acid binding 21/1315 187/18639 0.112299465240642 1.5917488460991 0.0233347997442767 0.217722015471153 GO:0001091 RNA polymerase II general transcription initiation factor binding 5/1315 24/18639 0.208333333333333 2.95294676806084 0.023895738270124 0.220982712321058 GO:0043177 organic acid binding 21/1315 189/18639 0.111111111111111 1.57490494296578 0.0258926612464707 0.237349394759315 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 9/1315 61/18639 0.147540983606557 2.091267219348 0.0264496335214413 0.240346669825271 GO:0051087 protein-folding chaperone binding 16/1315 134/18639 0.119402985074627 1.69243516259009 0.0267464177322338 0.240948332156762 GO:0016018 cyclosporin A binding 4/1315 17/18639 0.235294117647059 3.33509282039812 0.0279811556306865 0.247799217237859 GO:0070402 NADPH binding 4/1315 17/18639 0.235294117647059 3.33509282039812 0.0279811556306865 0.247799217237859 GO:0005528 FK506 binding 3/1315 10/18639 0.3 4.2522433460076 0.0288910372015333 0.249513503104151 GO:0035374 chondroitin sulfate binding 3/1315 10/18639 0.3 4.2522433460076 0.0288910372015333 0.249513503104151 GO:0043295 glutathione binding 3/1315 10/18639 0.3 4.2522433460076 0.0288910372015333 0.249513503104151 GO:0008200 ion channel inhibitor activity 7/1315 43/18639 0.162790697674419 2.30741886992661 0.0295440304419132 0.253061572227863 GO:1901505 carbohydrate derivative transmembrane transporter activity 8/1315 53/18639 0.150943396226415 2.13949350742521 0.0312752016142343 0.26571207875508 GO:0005507 copper ion binding 9/1315 63/18639 0.142857142857143 2.02487778381315 0.0318769932236925 0.268640789667409 GO:0016229 steroid dehydrogenase activity 6/1315 35/18639 0.171428571428571 2.42985334057577 0.0339521905786375 0.277564569984433 GO:0003746 translation elongation factor activity 4/1315 18/18639 0.222222222222222 3.14980988593156 0.0340203678234627 0.277564569984433 GO:0035615 clathrin adaptor activity 4/1315 18/18639 0.222222222222222 3.14980988593156 0.0340203678234627 0.277564569984433 GO:1901611 phosphatidylglycerol binding 4/1315 18/18639 0.222222222222222 3.14980988593156 0.0340203678234627 0.277564569984433 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 8/1315 54/18639 0.148148148148148 2.09987325728771 0.0345295637301209 0.277564569984433 GO:0051287 NAD binding 8/1315 54/18639 0.148148148148148 2.09987325728771 0.0345295637301209 0.277564569984433 GO:0010854 adenylate cyclase regulator activity 3/1315 11/18639 0.272727272727273 3.86567576909782 0.0376835861065214 0.291698870231962 GO:0015217 ADP transmembrane transporter activity 3/1315 11/18639 0.272727272727273 3.86567576909782 0.0376835861065214 0.291698870231962 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 3/1315 11/18639 0.272727272727273 3.86567576909782 0.0376835861065214 0.291698870231962 GO:1900750 oligopeptide binding 3/1315 11/18639 0.272727272727273 3.86567576909782 0.0376835861065214 0.291698870231962 GO:1990948 ubiquitin ligase inhibitor activity 3/1315 11/18639 0.272727272727273 3.86567576909782 0.0376835861065214 0.291698870231962 GO:0004364 glutathione transferase activity 5/1315 27/18639 0.185185185185185 2.62484157160963 0.0381449436113316 0.292893199248818 GO:0004033 aldo-keto reductase (NADPH) activity 6/1315 36/18639 0.166666666666667 2.36235741444867 0.0383984385618068 0.292893199248818 GO:0005520 insulin-like growth factor binding 4/1315 19/18639 0.210526315789474 2.98403041825095 0.0407571980510739 0.308632405531683 GO:0016866 intramolecular transferase activity 5/1315 28/18639 0.178571428571429 2.53109722976643 0.0438353219810718 0.32955331992964 GO:0004300 enoyl-CoA hydratase activity 3/1315 12/18639 0.25 3.543536121673 0.0476731451050811 0.34260303412807 GO:0005527 macrolide binding 3/1315 12/18639 0.25 3.543536121673 0.0476731451050811 0.34260303412807 GO:0016801 hydrolase activity, acting on ether bonds 3/1315 12/18639 0.25 3.543536121673 0.0476731451050811 0.34260303412807 GO:0016803 ether hydrolase activity 3/1315 12/18639 0.25 3.543536121673 0.0476731451050811 0.34260303412807 GO:0016840 carbon-nitrogen lyase activity 3/1315 12/18639 0.25 3.543536121673 0.0476731451050811 0.34260303412807 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 3/1315 12/18639 0.25 3.543536121673 0.0476731451050811 0.34260303412807 GO:0010851 cyclase regulator activity 4/1315 20/18639 0.2 2.8348288973384 0.0481939196333266 0.34260303412807 GO:0031418 L-ascorbic acid binding 4/1315 20/18639 0.2 2.8348288973384 0.0481939196333266 0.34260303412807 GO:0061134 peptidase regulator activity 23/1315 226/18639 0.101769911504425 1.44250143006158 0.0488936107621485 0.345228535448954 GO:0016247 channel regulator activity 18/1315 168/18639 0.107142857142857 1.51865833785986 0.050036204368717 0.350925057485297 GO:0033293 monocarboxylic acid binding 10/1315 79/18639 0.126582278481013 1.79419550464456 0.0505787197295486 0.352365080782522 GO:0003714 transcription corepressor activity 21/1315 204/18639 0.102941176470588 1.45910310892418 0.0523452082731115 0.362256573810606 GO:0141108 transporter regulator activity 18/1315 170/18639 0.105882352941176 1.50079176917915 0.0549931128188546 0.378077650629626 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 4/1315 21/18639 0.19047619047619 2.69983704508419 0.0563269638130943 0.379561346670417 GO:0140312 cargo adaptor activity 4/1315 21/18639 0.19047619047619 2.69983704508419 0.0563269638130943 0.379561346670417 GO:0019838 growth factor binding 15/1315 136/18639 0.110294117647059 1.56332475956162 0.0564201223419468 0.379561346670417 GO:0031210 phosphatidylcholine binding 5/1315 30/18639 0.166666666666667 2.36235741444867 0.0566617895507991 0.379561346670417 GO:0008253 5'-nucleotidase activity 3/1315 13/18639 0.230769230769231 3.27095642000585 0.0588162737286959 0.391484114945778 GO:0070034 telomerase RNA binding 4/1315 22/18639 0.181818181818182 2.57711717939855 0.0651473721037687 0.430879771192647 GO:0005048 signal sequence binding 7/1315 51/18639 0.137254901960784 1.9454708118989 0.0655986464823213 0.431135758327206 GO:0004521 RNA endonuclease activity 9/1315 73/18639 0.123287671232877 1.74749726548258 0.0705438427684384 0.452776845480752 GO:0043539 protein serine/threonine kinase activator activity 9/1315 73/18639 0.123287671232877 1.74749726548258 0.0705438427684384 0.452776845480752 GO:0005347 ATP transmembrane transporter activity 3/1315 14/18639 0.214285714285714 3.03731667571972 0.0710578015874099 0.452776845480752 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 3/1315 14/18639 0.214285714285714 3.03731667571972 0.0710578015874099 0.452776845480752 GO:1901612 cardiolipin binding 3/1315 14/18639 0.214285714285714 3.03731667571972 0.0710578015874099 0.452776845480752 GO:0008307 structural constituent of muscle 6/1315 42/18639 0.142857142857143 2.02487778381315 0.072652547849892 0.460132803049316 GO:0004864 protein phosphatase inhibitor activity 7/1315 53/18639 0.132075471698113 1.87205681899706 0.0775179954107702 0.485067695833862 GO:0140296 general transcription initiation factor binding 7/1315 53/18639 0.132075471698113 1.87205681899706 0.0775179954107702 0.485067695833862 GO:0050661 NADP binding 7/1315 54/18639 0.12962962962963 1.83738910012674 0.0839205277887392 0.520671542846669 GO:0008252 nucleotidase activity 3/1315 15/18639 0.2 2.8348288973384 0.0843335331554223 0.520671542846669 GO:0004540 RNA nuclease activity 13/1315 121/18639 0.107438016528926 1.5228419696446 0.0847025476401279 0.520671542846669 GO:0160215 deacylase activity 8/1315 65/18639 0.123076923076923 1.74451009066979 0.0858012349662134 0.524340880349082 GO:0016790 thiolester hydrolase activity 6/1315 44/18639 0.136363636363636 1.93283788454891 0.086996676991878 0.528555392189026 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 5/1315 34/18639 0.147058823529412 2.08443301274883 0.0880751987436642 0.532014928827335 GO:0003712 transcription coregulator activity 43/1315 495/18639 0.0868686868686869 1.23128931904597 0.0915898578649589 0.55006552568323 GO:0051539 4 iron, 4 sulfur cluster binding 6/1315 45/18639 0.133333333333333 1.88988593155894 0.0947089778301971 0.565547896186034 GO:0047617 fatty acyl-CoA hydrolase activity 4/1315 25/18639 0.16 2.26786311787072 0.095572479450161 0.567461596735331 GO:0003727 single-stranded RNA binding 10/1315 89/18639 0.112359550561798 1.5926005041227 0.0961155409597064 0.567461809620866 GO:0019212 phosphatase inhibitor activity 7/1315 56/18639 0.125 1.7717680608365 0.0976032831037686 0.568755542648301 GO:0008142 oxysterol binding 3/1315 16/18639 0.1875 2.65765209125475 0.0985725711774183 0.568755542648301 GO:0034450 ubiquitin-ubiquitin ligase activity 3/1315 16/18639 0.1875 2.65765209125475 0.0985725711774183 0.568755542648301 GO:0097027 ubiquitin-protein transferase activator activity 3/1315 16/18639 0.1875 2.65765209125475 0.0985725711774183 0.568755542648301 GO:0044325 transmembrane transporter binding 14/1315 136/18639 0.102941176470588 1.45910310892418 0.0990559892459241 0.568755542648301 GO:0008201 heparin binding 17/1315 172/18639 0.0988372093023256 1.40093288531258 0.0997300853121585 0.56949693525249 GO:0008198 ferrous iron binding 4/1315 26/18639 0.153846153846154 2.18063761333723 0.106961917112048 0.600344183129858 GO:0016289 acyl-CoA hydrolase activity 4/1315 26/18639 0.153846153846154 2.18063761333723 0.106961917112048 0.600344183129858 GO:0120014 phospholipid transfer activity 4/1315 26/18639 0.153846153846154 2.18063761333723 0.106961917112048 0.600344183129858 GO:0072341 modified amino acid binding 10/1315 91/18639 0.10989010989011 1.55759829524088 0.107430011717975 0.600344183129858 GO:0043495 protein-membrane adaptor activity 6/1315 47/18639 0.127659574468085 1.80946525362026 0.111186559477158 0.615625760201567 GO:0052689 carboxylic ester hydrolase activity 10/1315 92/18639 0.108695652173913 1.54066787898826 0.113361012952824 0.615625760201567 GO:0016805 dipeptidase activity 3/1315 17/18639 0.176470588235294 2.50131961529859 0.113699303080289 0.615625760201567 GO:0030169 low-density lipoprotein particle binding 3/1315 17/18639 0.176470588235294 2.50131961529859 0.113699303080289 0.615625760201567 GO:0048038 quinone binding 3/1315 17/18639 0.176470588235294 2.50131961529859 0.113699303080289 0.615625760201567 GO:0051787 misfolded protein binding 3/1315 17/18639 0.176470588235294 2.50131961529859 0.113699303080289 0.615625760201567 GO:0043394 proteoglycan binding 5/1315 37/18639 0.135135135135135 1.91542493063406 0.116463703256255 0.627343143828797 GO:0001098 basal transcription machinery binding 7/1315 60/18639 0.116666666666667 1.65365019011407 0.128382019860662 0.678948713464399 GO:0001099 basal RNA polymerase II transcription machinery binding 7/1315 60/18639 0.116666666666667 1.65365019011407 0.128382019860662 0.678948713464399 GO:0008308 voltage-gated monoatomic anion channel activity 3/1315 18/18639 0.166666666666667 2.36235741444867 0.129635090131655 0.678948713464399 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 3/1315 18/18639 0.166666666666667 2.36235741444867 0.129635090131655 0.678948713464399 GO:0017128 phospholipid scramblase activity 3/1315 18/18639 0.166666666666667 2.36235741444867 0.129635090131655 0.678948713464399 GO:0001540 amyloid-beta binding 9/1315 83/18639 0.108433734939759 1.53695542626781 0.129942337505148 0.678948713464399 GO:0046966 nuclear thyroid hormone receptor binding 4/1315 28/18639 0.142857142857143 2.02487778381315 0.131445880489096 0.680004678767846 GO:0097718 disordered domain specific binding 4/1315 28/18639 0.142857142857143 2.02487778381315 0.131445880489096 0.680004678767846 GO:0019888 protein phosphatase regulator activity 11/1315 107/18639 0.102803738317757 1.45715504068796 0.133454904417824 0.68699692175678 GO:0004860 protein kinase inhibitor activity 9/1315 84/18639 0.107142857142857 1.51865833785986 0.13700849458476 0.701325199094838 GO:0035250 UDP-galactosyltransferase activity 4/1315 29/18639 0.137931034482759 1.95505441195752 0.144476132810315 0.701325199094838 GO:0043236 laminin binding 4/1315 29/18639 0.137931034482759 1.95505441195752 0.144476132810315 0.701325199094838 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 3/1315 19/18639 0.157894736842105 2.23802281368821 0.146299694896764 0.701325199094838 GO:0005346 purine ribonucleotide transmembrane transporter activity 3/1315 19/18639 0.157894736842105 2.23802281368821 0.146299694896764 0.701325199094838 GO:0030506 ankyrin binding 3/1315 19/18639 0.157894736842105 2.23802281368821 0.146299694896764 0.701325199094838 GO:0043395 heparan sulfate proteoglycan binding 3/1315 19/18639 0.157894736842105 2.23802281368821 0.146299694896764 0.701325199094838 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 5/1315 40/18639 0.125 1.7717680608365 0.148608254853257 0.701325199094838 GO:0048029 monosaccharide binding 8/1315 74/18639 0.108108108108108 1.53233994450724 0.149496078436133 0.701325199094838 GO:0004935 adrenergic receptor activity 2/1315 10/18639 0.2 2.8348288973384 0.153640765724781 0.701325199094838 GO:0005337 nucleoside transmembrane transporter activity 2/1315 10/18639 0.2 2.8348288973384 0.153640765724781 0.701325199094838 GO:0005345 purine nucleobase transmembrane transporter activity 2/1315 10/18639 0.2 2.8348288973384 0.153640765724781 0.701325199094838 GO:0015187 glycine transmembrane transporter activity 2/1315 10/18639 0.2 2.8348288973384 0.153640765724781 0.701325199094838 GO:0015643 toxic substance binding 2/1315 10/18639 0.2 2.8348288973384 0.153640765724781 0.701325199094838 GO:0016175 superoxide-generating NAD(P)H oxidase activity 2/1315 10/18639 0.2 2.8348288973384 0.153640765724781 0.701325199094838 GO:0016783 sulfurtransferase activity 2/1315 10/18639 0.2 2.8348288973384 0.153640765724781 0.701325199094838 GO:0031419 cobalamin binding 2/1315 10/18639 0.2 2.8348288973384 0.153640765724781 0.701325199094838 GO:0031434 mitogen-activated protein kinase kinase binding 2/1315 10/18639 0.2 2.8348288973384 0.153640765724781 0.701325199094838 GO:0043208 glycosphingolipid binding 2/1315 10/18639 0.2 2.8348288973384 0.153640765724781 0.701325199094838 GO:0047429 nucleoside triphosphate diphosphatase activity 2/1315 10/18639 0.2 2.8348288973384 0.153640765724781 0.701325199094838 GO:0051378 serotonin binding 2/1315 10/18639 0.2 2.8348288973384 0.153640765724781 0.701325199094838 GO:0051880 G-quadruplex DNA binding 2/1315 10/18639 0.2 2.8348288973384 0.153640765724781 0.701325199094838 GO:0070513 death domain binding 2/1315 10/18639 0.2 2.8348288973384 0.153640765724781 0.701325199094838 GO:0098505 G-rich strand telomeric DNA binding 2/1315 10/18639 0.2 2.8348288973384 0.153640765724781 0.701325199094838 GO:0141109 transporter activator activity 2/1315 10/18639 0.2 2.8348288973384 0.153640765724781 0.701325199094838 GO:0004518 nuclease activity 19/1315 209/18639 0.0909090909090909 1.28855858969927 0.153687531667673 0.701325199094838 GO:0044183 protein folding chaperone 8/1315 75/18639 0.106666666666667 1.51190874524715 0.15770507866054 0.712283598466291 GO:0035925 mRNA 3'-UTR AU-rich region binding 4/1315 30/18639 0.133333333333333 1.88988593155894 0.157986031773317 0.712283598466291 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 6/1315 52/18639 0.115384615384615 1.63547821000292 0.158133774970507 0.712283598466291 GO:0017080 sodium channel regulator activity 5/1315 41/18639 0.121951219512195 1.72855420569415 0.160077749402366 0.71239600129703 GO:0061650 ubiquitin-like protein conjugating enzyme activity 5/1315 41/18639 0.121951219512195 1.72855420569415 0.160077749402366 0.71239600129703 GO:0042277 peptide binding 22/1315 249/18639 0.0883534136546185 1.25233405103303 0.162841863367738 0.71239600129703 GO:0002020 protease binding 13/1315 136/18639 0.0955882352941176 1.35488145828674 0.16317192442227 0.71239600129703 GO:0000339 RNA cap binding 3/1315 20/18639 0.15 2.1261216730038 0.163612478766782 0.71239600129703 GO:0016004 phospholipase activator activity 3/1315 20/18639 0.15 2.1261216730038 0.163612478766782 0.71239600129703 GO:0016408 C-acyltransferase activity 3/1315 20/18639 0.15 2.1261216730038 0.163612478766782 0.71239600129703 GO:0043024 ribosomal small subunit binding 3/1315 20/18639 0.15 2.1261216730038 0.163612478766782 0.71239600129703 GO:0017022 myosin binding 8/1315 76/18639 0.105263157894737 1.49201520912548 0.166121672261567 0.720320114163225 GO:0004197 cysteine-type endopeptidase activity 9/1315 88/18639 0.102272727272727 1.44962841341168 0.16717312663544 0.721883955925763 GO:0008083 growth factor activity 15/1315 162/18639 0.0925925925925926 1.31242078580482 0.170305467240917 0.731891286697652 GO:0000099 sulfur amino acid transmembrane transporter activity 2/1315 11/18639 0.181818181818182 2.57711717939855 0.179409027862172 0.731891286697652 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 2/1315 11/18639 0.181818181818182 2.57711717939855 0.179409027862172 0.731891286697652 GO:0015173 aromatic amino acid transmembrane transporter activity 2/1315 11/18639 0.181818181818182 2.57711717939855 0.179409027862172 0.731891286697652 GO:0015205 nucleobase transmembrane transporter activity 2/1315 11/18639 0.181818181818182 2.57711717939855 0.179409027862172 0.731891286697652 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 2/1315 11/18639 0.181818181818182 2.57711717939855 0.179409027862172 0.731891286697652 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 2/1315 11/18639 0.181818181818182 2.57711717939855 0.179409027862172 0.731891286697652 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 2/1315 11/18639 0.181818181818182 2.57711717939855 0.179409027862172 0.731891286697652 GO:0032050 clathrin heavy chain binding 2/1315 11/18639 0.181818181818182 2.57711717939855 0.179409027862172 0.731891286697652 GO:0034511 U3 snoRNA binding 2/1315 11/18639 0.181818181818182 2.57711717939855 0.179409027862172 0.731891286697652 GO:0048407 platelet-derived growth factor binding 2/1315 11/18639 0.181818181818182 2.57711717939855 0.179409027862172 0.731891286697652 GO:0140031 phosphorylation-dependent protein binding 2/1315 11/18639 0.181818181818182 2.57711717939855 0.179409027862172 0.731891286697652 GO:0140537 transcription regulator activator activity 2/1315 11/18639 0.181818181818182 2.57711717939855 0.179409027862172 0.731891286697652 GO:0051428 peptide hormone receptor binding 3/1315 21/18639 0.142857142857143 2.02487778381315 0.18149339792573 0.731891286697652 GO:0072542 protein phosphatase activator activity 3/1315 21/18639 0.142857142857143 2.02487778381315 0.18149339792573 0.731891286697652 GO:0019210 kinase inhibitor activity 9/1315 90/18639 0.1 1.4174144486692 0.183332215360731 0.731891286697652 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 5/1315 43/18639 0.116279069767442 1.64815633566186 0.184029972089954 0.731891286697652 GO:0048156 tau protein binding 5/1315 43/18639 0.116279069767442 1.64815633566186 0.184029972089954 0.731891286697652 GO:0004519 endonuclease activity 12/1315 127/18639 0.094488188976378 1.33928924283704 0.185116806603534 0.731891286697652 GO:0008378 galactosyltransferase activity 4/1315 32/18639 0.125 1.7717680608365 0.186299600250312 0.731891286697652 GO:0031369 translation initiation factor binding 4/1315 32/18639 0.125 1.7717680608365 0.186299600250312 0.731891286697652 GO:0043425 bHLH transcription factor binding 4/1315 32/18639 0.125 1.7717680608365 0.186299600250312 0.731891286697652 GO:0071813 lipoprotein particle binding 4/1315 32/18639 0.125 1.7717680608365 0.186299600250312 0.731891286697652 GO:0071814 protein-lipid complex binding 4/1315 32/18639 0.125 1.7717680608365 0.186299600250312 0.731891286697652 GO:0005539 glycosaminoglycan binding 21/1315 242/18639 0.0867768595041322 1.22998774471294 0.190623533329554 0.746073379510803 GO:0050840 extracellular matrix binding 7/1315 67/18639 0.104477611940299 1.48088076726633 0.192183857994802 0.74937362539018 GO:0016881 acid-amino acid ligase activity 3/1315 22/18639 0.136363636363636 1.93283788454891 0.199863823055513 0.751801516126579 GO:0031683 G-protein beta/gamma-subunit complex binding 3/1315 22/18639 0.136363636363636 1.93283788454891 0.199863823055513 0.751801516126579 GO:0140517 protein-RNA adaptor activity 3/1315 22/18639 0.136363636363636 1.93283788454891 0.199863823055513 0.751801516126579 GO:0140416 transcription regulator inhibitor activity 4/1315 33/18639 0.121212121212121 1.71807811959903 0.201028777838015 0.751801516126579 GO:0000049 tRNA binding 8/1315 80/18639 0.1 1.4174144486692 0.20172926251637 0.751801516126579 GO:0005548 phospholipid transporter activity 7/1315 68/18639 0.102941176470588 1.45910310892418 0.202199044869967 0.751801516126579 GO:0019208 phosphatase regulator activity 11/1315 117/18639 0.094017094017094 1.3326118748172 0.202674315839755 0.751801516126579 GO:0003995 acyl-CoA dehydrogenase activity 2/1315 12/18639 0.166666666666667 2.36235741444867 0.20575620441359 0.751801516126579 GO:0004032 aldose reductase (NADPH) activity 2/1315 12/18639 0.166666666666667 2.36235741444867 0.20575620441359 0.751801516126579 GO:0004859 phospholipase inhibitor activity 2/1315 12/18639 0.166666666666667 2.36235741444867 0.20575620441359 0.751801516126579 GO:0008603 cAMP-dependent protein kinase regulator activity 2/1315 12/18639 0.166666666666667 2.36235741444867 0.20575620441359 0.751801516126579 GO:0015368 calcium:monoatomic cation antiporter activity 2/1315 12/18639 0.166666666666667 2.36235741444867 0.20575620441359 0.751801516126579 GO:0016208 AMP binding 2/1315 12/18639 0.166666666666667 2.36235741444867 0.20575620441359 0.751801516126579 GO:0017166 vinculin binding 2/1315 12/18639 0.166666666666667 2.36235741444867 0.20575620441359 0.751801516126579 GO:0031543 peptidyl-proline dioxygenase activity 2/1315 12/18639 0.166666666666667 2.36235741444867 0.20575620441359 0.751801516126579 GO:0043047 single-stranded telomeric DNA binding 2/1315 12/18639 0.166666666666667 2.36235741444867 0.20575620441359 0.751801516126579 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 2/1315 12/18639 0.166666666666667 2.36235741444867 0.20575620441359 0.751801516126579 GO:0097371 MDM2/MDM4 family protein binding 2/1315 12/18639 0.166666666666667 2.36235741444867 0.20575620441359 0.751801516126579 GO:0051213 dioxygenase activity 9/1315 93/18639 0.0967741935483871 1.37169140193794 0.208797903274577 0.760257173944016 GO:0015932 nucleobase-containing compound transmembrane transporter activity 6/1315 57/18639 0.105263157894737 1.49201520912548 0.212167656213875 0.769844447026041 GO:0030332 cyclin binding 4/1315 34/18639 0.117647058823529 1.66754641019906 0.216089255050595 0.777164386245015 GO:0051427 hormone receptor binding 4/1315 34/18639 0.117647058823529 1.66754641019906 0.216089255050595 0.777164386245015 GO:0000295 adenine nucleotide transmembrane transporter activity 3/1315 23/18639 0.130434782608696 1.84880145478591 0.218647205316779 0.777164386245015 GO:0017134 fibroblast growth factor binding 3/1315 23/18639 0.130434782608696 1.84880145478591 0.218647205316779 0.777164386245015 GO:0031681 G-protein beta-subunit binding 3/1315 23/18639 0.130434782608696 1.84880145478591 0.218647205316779 0.777164386245015 GO:0070577 lysine-acetylated histone binding 3/1315 23/18639 0.130434782608696 1.84880145478591 0.218647205316779 0.777164386245015 GO:0051015 actin filament binding 18/1315 209/18639 0.0861244019138756 1.22073971655721 0.221966223468611 0.781349814617836 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 5/1315 46/18639 0.108695652173913 1.54066787898826 0.222167816446634 0.781349814617836 GO:0061135 endopeptidase regulator activity 16/1315 184/18639 0.0869565217391304 1.23253430319061 0.227166723256894 0.781349814617836 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 2/1315 13/18639 0.153846153846154 2.18063761333723 0.232472555447207 0.781349814617836 GO:0004993 G protein-coupled serotonin receptor activity 2/1315 13/18639 0.153846153846154 2.18063761333723 0.232472555447207 0.781349814617836 GO:0005338 nucleotide-sugar transmembrane transporter activity 2/1315 13/18639 0.153846153846154 2.18063761333723 0.232472555447207 0.781349814617836 GO:0005542 folic acid binding 2/1315 13/18639 0.153846153846154 2.18063761333723 0.232472555447207 0.781349814617836 GO:0017154 semaphorin receptor activity 2/1315 13/18639 0.153846153846154 2.18063761333723 0.232472555447207 0.781349814617836 GO:0019855 calcium channel inhibitor activity 2/1315 13/18639 0.153846153846154 2.18063761333723 0.232472555447207 0.781349814617836 GO:0030955 potassium ion binding 2/1315 13/18639 0.153846153846154 2.18063761333723 0.232472555447207 0.781349814617836 GO:0031432 titin binding 2/1315 13/18639 0.153846153846154 2.18063761333723 0.232472555447207 0.781349814617836 GO:0045159 myosin II binding 2/1315 13/18639 0.153846153846154 2.18063761333723 0.232472555447207 0.781349814617836 GO:0070700 BMP receptor binding 2/1315 13/18639 0.153846153846154 2.18063761333723 0.232472555447207 0.781349814617836 GO:0071837 HMG box domain binding 2/1315 13/18639 0.153846153846154 2.18063761333723 0.232472555447207 0.781349814617836 GO:1901338 catecholamine binding 2/1315 13/18639 0.153846153846154 2.18063761333723 0.232472555447207 0.781349814617836 GO:0070063 RNA polymerase binding 6/1315 59/18639 0.101694915254237 1.44143842237546 0.235381165898083 0.781349814617836 GO:0015295 solute:proton symporter activity 3/1315 24/18639 0.125 1.7717680608365 0.237769608658825 0.781349814617836 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 3/1315 24/18639 0.125 1.7717680608365 0.237769608658825 0.781349814617836 GO:0030215 semaphorin receptor binding 3/1315 24/18639 0.125 1.7717680608365 0.237769608658825 0.781349814617836 GO:0050431 transforming growth factor beta binding 3/1315 24/18639 0.125 1.7717680608365 0.237769608658825 0.781349814617836 GO:0060229 lipase activator activity 3/1315 24/18639 0.125 1.7717680608365 0.237769608658825 0.781349814617836 GO:0070300 phosphatidic acid binding 3/1315 24/18639 0.125 1.7717680608365 0.237769608658825 0.781349814617836 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 3/1315 24/18639 0.125 1.7717680608365 0.237769608658825 0.781349814617836 GO:0140033 acetylation-dependent protein binding 3/1315 24/18639 0.125 1.7717680608365 0.237769608658825 0.781349814617836 GO:0099106 ion channel regulator activity 14/1315 160/18639 0.0875 1.24023764258555 0.239075800899726 0.783179347774963 GO:0051117 ATPase binding 8/1315 84/18639 0.0952380952380952 1.3499185225421 0.240079690686348 0.784010239897606 GO:0005484 SNAP receptor activity 4/1315 36/18639 0.111111111111111 1.57490494296578 0.2470532948638 0.804270072064395 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 5/1315 48/18639 0.104166666666667 1.47647338403042 0.248803428911663 0.80495227000832 GO:0016879 ligase activity, forming carbon-nitrogen bonds 5/1315 48/18639 0.104166666666667 1.47647338403042 0.248803428911663 0.80495227000832 GO:0140098 catalytic activity, acting on RNA 31/1315 387/18639 0.0801033591731266 1.13539658678928 0.255427482804567 0.813954624843583 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 3/1315 25/18639 0.12 1.70089733840304 0.257160126278188 0.813954624843583 GO:0017025 TBP-class protein binding 3/1315 25/18639 0.12 1.70089733840304 0.257160126278188 0.813954624843583 GO:0019211 phosphatase activator activity 3/1315 25/18639 0.12 1.70089733840304 0.257160126278188 0.813954624843583 GO:0005161 platelet-derived growth factor receptor binding 2/1315 14/18639 0.142857142857143 2.02487778381315 0.25937501442384 0.813954624843583 GO:0042043 neurexin family protein binding 2/1315 14/18639 0.142857142857143 2.02487778381315 0.25937501442384 0.813954624843583 GO:0043176 amine binding 2/1315 14/18639 0.142857142857143 2.02487778381315 0.25937501442384 0.813954624843583 GO:0044548 S100 protein binding 2/1315 14/18639 0.142857142857143 2.02487778381315 0.25937501442384 0.813954624843583 GO:0070742 C2H2 zinc finger domain binding 2/1315 14/18639 0.142857142857143 2.02487778381315 0.25937501442384 0.813954624843583 GO:0098847 sequence-specific single stranded DNA binding 2/1315 14/18639 0.142857142857143 2.02487778381315 0.25937501442384 0.813954624843583 GO:0042805 actinin binding 4/1315 37/18639 0.108108108108108 1.53233994450724 0.262882336270775 0.822491141925029 GO:0015605 organophosphate ester transmembrane transporter activity 5/1315 50/18639 0.1 1.4174144486692 0.276192935310142 0.85563609735427 GO:0005112 Notch binding 3/1315 26/18639 0.115384615384615 1.63547821000292 0.276751197038989 0.85563609735427 GO:0015216 purine nucleotide transmembrane transporter activity 3/1315 26/18639 0.115384615384615 1.63547821000292 0.276751197038989 0.85563609735427 GO:0097602 cullin family protein binding 3/1315 26/18639 0.115384615384615 1.63547821000292 0.276751197038989 0.85563609735427 GO:0042162 telomeric DNA binding 4/1315 38/18639 0.105263157894737 1.49201520912548 0.278894052806341 0.857189074066547 GO:0043531 ADP binding 4/1315 38/18639 0.105263157894737 1.49201520912548 0.278894052806341 0.857189074066547 GO:0004865 protein serine/threonine phosphatase inhibitor activity 2/1315 15/18639 0.133333333333333 1.88988593155894 0.28630447308052 0.862213758988886 GO:0015929 hexosaminidase activity 2/1315 15/18639 0.133333333333333 1.88988593155894 0.28630447308052 0.862213758988886 GO:0016846 carbon-sulfur lyase activity 2/1315 15/18639 0.133333333333333 1.88988593155894 0.28630447308052 0.862213758988886 GO:0017081 chloride channel regulator activity 2/1315 15/18639 0.133333333333333 1.88988593155894 0.28630447308052 0.862213758988886 GO:0033130 acetylcholine receptor binding 2/1315 15/18639 0.133333333333333 1.88988593155894 0.28630447308052 0.862213758988886 GO:0050700 CARD domain binding 2/1315 15/18639 0.133333333333333 1.88988593155894 0.28630447308052 0.862213758988886 GO:0051371 muscle alpha-actinin binding 2/1315 15/18639 0.133333333333333 1.88988593155894 0.28630447308052 0.862213758988886 GO:0005506 iron ion binding 13/1315 154/18639 0.0844155844155844 1.19651869043504 0.291438432808238 0.875152765185658 GO:0005385 zinc ion transmembrane transporter activity 3/1315 27/18639 0.111111111111111 1.57490494296578 0.296478835866797 0.885201095659437 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 3/1315 27/18639 0.111111111111111 1.57490494296578 0.296478835866797 0.885201095659437 GO:0004532 RNA exonuclease activity 4/1315 40/18639 0.1 1.4174144486692 0.311324600481685 0.915555446219299 GO:0030331 nuclear estrogen receptor binding 4/1315 40/18639 0.1 1.4174144486692 0.311324600481685 0.915555446219299 GO:0000062 fatty-acyl-CoA binding 2/1315 16/18639 0.125 1.7717680608365 0.313123316209535 0.915555446219299 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 2/1315 16/18639 0.125 1.7717680608365 0.313123316209535 0.915555446219299 GO:0030275 LRR domain binding 2/1315 16/18639 0.125 1.7717680608365 0.313123316209535 0.915555446219299 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 2/1315 16/18639 0.125 1.7717680608365 0.313123316209535 0.915555446219299 GO:0055102 lipase inhibitor activity 2/1315 16/18639 0.125 1.7717680608365 0.313123316209535 0.915555446219299 GO:0045499 chemorepellent activity 3/1315 28/18639 0.107142857142857 1.51865833785986 0.316282790512122 0.915555446219299 GO:0051119 sugar transmembrane transporter activity 3/1315 28/18639 0.107142857142857 1.51865833785986 0.316282790512122 0.915555446219299 GO:0051393 alpha-actinin binding 3/1315 28/18639 0.107142857142857 1.51865833785986 0.316282790512122 0.915555446219299 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 3/1315 28/18639 0.107142857142857 1.51865833785986 0.316282790512122 0.915555446219299 GO:0043178 alcohol binding 8/1315 92/18639 0.0869565217391304 1.23253430319061 0.322821803054969 0.931902718763653 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 4/1315 41/18639 0.0975609756097561 1.38284336455532 0.327675611409179 0.938139764171485 GO:0008227 G protein-coupled amine receptor activity 4/1315 41/18639 0.0975609756097561 1.38284336455532 0.327675611409179 0.938139764171485 GO:0015175 neutral L-amino acid transmembrane transporter activity 4/1315 41/18639 0.0975609756097561 1.38284336455532 0.327675611409179 0.938139764171485 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 6/1315 67/18639 0.0895522388059701 1.26932637194257 0.334278625485683 0.954301822405837 GO:0004029 aldehyde dehydrogenase (NAD+) activity 2/1315 17/18639 0.117647058823529 1.66754641019906 0.339713184626767 0.954301822405837 GO:0005092 GDP-dissociation inhibitor activity 2/1315 17/18639 0.117647058823529 1.66754641019906 0.339713184626767 0.954301822405837 GO:0008429 phosphatidylethanolamine binding 2/1315 17/18639 0.117647058823529 1.66754641019906 0.339713184626767 0.954301822405837 GO:0046965 nuclear retinoid X receptor binding 2/1315 17/18639 0.117647058823529 1.66754641019906 0.339713184626767 0.954301822405837 GO:0070492 oligosaccharide binding 2/1315 17/18639 0.117647058823529 1.66754641019906 0.339713184626767 0.954301822405837 GO:1901567 fatty acid derivative binding 2/1315 17/18639 0.117647058823529 1.66754641019906 0.339713184626767 0.954301822405837 GO:0019887 protein kinase regulator activity 20/1315 255/18639 0.0784313725490196 1.11169760679937 0.344184823601014 0.964271154592652 GO:0140313 molecular sequestering activity 5/1315 55/18639 0.0909090909090909 1.28855858969927 0.346776220549493 0.968933557417702 GO:0003713 transcription coactivator activity 20/1315 256/18639 0.078125 1.10735503802281 0.35070933821014 0.976150171812973 GO:0015297 antiporter activity 11/1315 135/18639 0.0814814814814815 1.15493029150824 0.355181119414113 0.976150171812973 GO:0001968 fibronectin binding 3/1315 30/18639 0.1 1.4174144486692 0.355897813838031 0.976150171812973 GO:0015215 nucleotide transmembrane transporter activity 3/1315 30/18639 0.1 1.4174144486692 0.355897813838031 0.976150171812973 GO:0022839 monoatomic ion-gated channel activity 3/1315 30/18639 0.1 1.4174144486692 0.355897813838031 0.976150171812973 GO:0033612 receptor serine/threonine kinase binding 3/1315 30/18639 0.1 1.4174144486692 0.355897813838031 0.976150171812973 GO:0051721 protein phosphatase 2A binding 3/1315 30/18639 0.1 1.4174144486692 0.355897813838031 0.976150171812973 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 2/1315 18/18639 0.111111111111111 1.57490494296578 0.365972946438656 0.990781681420714 GO:0008409 5'-3' exonuclease activity 2/1315 18/18639 0.111111111111111 1.57490494296578 0.365972946438656 0.990781681420714 GO:0070064 proline-rich region binding 2/1315 18/18639 0.111111111111111 1.57490494296578 0.365972946438656 0.990781681420714 GO:0098641 cadherin binding involved in cell-cell adhesion 2/1315 18/18639 0.111111111111111 1.57490494296578 0.365972946438656 0.990781681420714 GO:1990381 ubiquitin-specific protease binding 2/1315 18/18639 0.111111111111111 1.57490494296578 0.365972946438656 0.990781681420714 GO:0016922 nuclear receptor binding 11/1315 137/18639 0.0802919708029197 1.13806999528184 0.373387268006595 0.999999999999966 GO:0005164 tumor necrosis factor receptor binding 3/1315 31/18639 0.0967741935483871 1.37169140193794 0.375607632211477 0.999999999999966 GO:0008327 methyl-CpG binding 3/1315 31/18639 0.0967741935483871 1.37169140193794 0.375607632211477 0.999999999999966 GO:0030547 signaling receptor inhibitor activity 4/1315 44/18639 0.0909090909090909 1.28855858969927 0.376890501947849 0.999999999999966 GO:0004527 exonuclease activity 7/1315 84/18639 0.0833333333333333 1.18117870722433 0.38129038136987 0.999999999999966 GO:0046906 tetrapyrrole binding 12/1315 152/18639 0.0789473684210526 1.11901140684411 0.386338929738631 0.999999999999966 GO:0042626 ATPase-coupled transmembrane transporter activity 8/1315 98/18639 0.0816326530612245 1.1570730193218 0.387865201410935 0.999999999999966 GO:0140101 catalytic activity, acting on a tRNA 11/1315 139/18639 0.079136690647482 1.12169488743606 0.391692357821179 0.999999999999966 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 2/1315 19/18639 0.105263157894737 1.49201520912548 0.391816858384761 0.999999999999966 GO:0005229 intracellularly calcium-gated chloride channel activity 2/1315 19/18639 0.105263157894737 1.49201520912548 0.391816858384761 0.999999999999966 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 2/1315 19/18639 0.105263157894737 1.49201520912548 0.391816858384761 0.999999999999966 GO:0031420 alkali metal ion binding 2/1315 19/18639 0.105263157894737 1.49201520912548 0.391816858384761 0.999999999999966 GO:0046624 sphingolipid transporter activity 2/1315 19/18639 0.105263157894737 1.49201520912548 0.391816858384761 0.999999999999966 GO:0050145 nucleoside monophosphate kinase activity 2/1315 19/18639 0.105263157894737 1.49201520912548 0.391816858384761 0.999999999999966 GO:0099589 serotonin receptor activity 2/1315 19/18639 0.105263157894737 1.49201520912548 0.391816858384761 0.999999999999966 GO:0120227 acyl-CoA binding 2/1315 19/18639 0.105263157894737 1.49201520912548 0.391816858384761 0.999999999999966 GO:0141147 intracellularly calcium-gated channel activity 2/1315 19/18639 0.105263157894737 1.49201520912548 0.391816858384761 0.999999999999966 GO:0140142 nucleocytoplasmic carrier activity 3/1315 32/18639 0.09375 1.32882604562738 0.395191221724701 0.999999999999966 GO:0003779 actin binding 33/1315 443/18639 0.0744920993227991 1.05586177891837 0.398171890803819 0.999999999999966 GO:0005518 collagen binding 6/1315 72/18639 0.0833333333333333 1.18117870722433 0.398462736964589 0.999999999999966 GO:0030276 clathrin binding 4/1315 46/18639 0.0869565217391304 1.23253430319061 0.409545182945622 0.999999999999966 GO:0030291 protein serine/threonine kinase inhibitor activity 4/1315 46/18639 0.0869565217391304 1.23253430319061 0.409545182945622 0.999999999999966 GO:0043130 ubiquitin binding 8/1315 100/18639 0.08 1.13393155893536 0.409728698430728 0.999999999999966 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 3/1315 33/18639 0.0909090909090909 1.28855858969927 0.414607466113369 0.999999999999966 GO:0001972 retinoic acid binding 2/1315 20/18639 0.1 1.4174144486692 0.417172900564536 0.999999999999966 GO:0061608 nuclear import signal receptor activity 2/1315 20/18639 0.1 1.4174144486692 0.417172900564536 0.999999999999966 GO:0016831 carboxy-lyase activity 3/1315 34/18639 0.0882352941176471 1.2506598076493 0.433818905893638 0.999999999999966 GO:0008373 sialyltransferase activity 2/1315 21/18639 0.0952380952380952 1.3499185225421 0.441981269263358 0.999999999999966 GO:0010314 phosphatidylinositol-5-phosphate binding 2/1315 21/18639 0.0952380952380952 1.3499185225421 0.441981269263358 0.999999999999966 GO:0035613 RNA stem-loop binding 2/1315 21/18639 0.0952380952380952 1.3499185225421 0.441981269263358 0.999999999999966 GO:0051010 microtubule plus-end binding 2/1315 21/18639 0.0952380952380952 1.3499185225421 0.441981269263358 0.999999999999966 GO:0005253 monoatomic anion channel activity 8/1315 103/18639 0.0776699029126214 1.10090442615084 0.44245989355861 0.999999999999966 GO:0000175 3'-5'-RNA exonuclease activity 3/1315 35/18639 0.0857142857142857 1.21492667028789 0.452791622495503 0.999999999999966 GO:0061631 ubiquitin conjugating enzyme activity 3/1315 35/18639 0.0857142857142857 1.21492667028789 0.452791622495503 0.999999999999966 GO:0001222 transcription corepressor binding 4/1315 49/18639 0.0816326530612245 1.1570730193218 0.457780520581347 0.999999999999966 GO:0019207 kinase regulator activity 21/1315 287/18639 0.0731707317073171 1.03713252341649 0.463845998940011 0.999999999999966 GO:0004190 aspartic-type endopeptidase activity 3/1315 36/18639 0.0833333333333333 1.18117870722433 0.471495106825658 0.999999999999966 GO:0044390 ubiquitin-like protein conjugating enzyme binding 3/1315 36/18639 0.0833333333333333 1.18117870722433 0.471495106825658 0.999999999999966 GO:0032813 tumor necrosis factor receptor superfamily binding 4/1315 50/18639 0.08 1.13393155893536 0.473570745387539 0.999999999999966 GO:0004536 DNA nuclease activity 5/1315 64/18639 0.078125 1.10735503802281 0.474498327066132 0.999999999999966 GO:0032182 ubiquitin-like protein binding 9/1315 120/18639 0.075 1.0630608365019 0.474747018565343 0.999999999999966 GO:0003697 single-stranded DNA binding 9/1315 121/18639 0.0743801652892562 1.05427520975395 0.484831493930431 0.999999999999966 GO:0120013 lipid transfer activity 5/1315 65/18639 0.0769230769230769 1.09031880666862 0.48829809736553 0.999999999999966 GO:0016830 carbon-carbon lyase activity 4/1315 51/18639 0.0784313725490196 1.11169760679937 0.489184160333313 0.999999999999966 GO:0030544 Hsp70 protein binding 4/1315 51/18639 0.0784313725490196 1.11169760679937 0.489184160333313 0.999999999999966 GO:0005158 insulin receptor binding 2/1315 23/18639 0.0869565217391304 1.23253430319061 0.489768805176273 0.999999999999966 GO:0005283 amino acid:sodium symporter activity 2/1315 23/18639 0.0869565217391304 1.23253430319061 0.489768805176273 0.999999999999966 GO:0008171 O-methyltransferase activity 2/1315 23/18639 0.0869565217391304 1.23253430319061 0.489768805176273 0.999999999999966 GO:0016849 phosphorus-oxygen lyase activity 2/1315 23/18639 0.0869565217391304 1.23253430319061 0.489768805176273 0.999999999999966 GO:0140103 catalytic activity, acting on a glycoprotein 2/1315 23/18639 0.0869565217391304 1.23253430319061 0.489768805176273 0.999999999999966 GO:0019213 deacetylase activity 3/1315 37/18639 0.0810810810810811 1.14925495838043 0.489902115992265 0.999999999999966 GO:0022829 wide pore channel activity 3/1315 37/18639 0.0810810810810811 1.14925495838043 0.489902115992265 0.999999999999966 GO:0023023 MHC protein complex binding 3/1315 37/18639 0.0810810810810811 1.14925495838043 0.489902115992265 0.999999999999966 GO:0070001 aspartic-type peptidase activity 3/1315 37/18639 0.0810810810810811 1.14925495838043 0.489902115992265 0.999999999999966 GO:0004175 endopeptidase activity 29/1315 405/18639 0.0716049382716049 1.01493874102239 0.494957272706498 0.999999999999966 GO:0005496 steroid binding 8/1315 108/18639 0.0740740740740741 1.04993662864385 0.496320453435353 0.999999999999966 GO:0048306 calcium-dependent protein binding 6/1315 80/18639 0.075 1.0630608365019 0.499796256816799 0.999999999999966 GO:0005525 GTP binding 27/1315 378/18639 0.0714285714285714 1.01243889190657 0.502449591237826 0.999999999999966 GO:0005080 protein kinase C binding 4/1315 52/18639 0.0769230769230769 1.09031880666862 0.504603384060679 0.999999999999966 GO:0000146 microfilament motor activity 3/1315 38/18639 0.0789473684210526 1.11901140684411 0.507988521408201 0.999999999999966 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 3/1315 38/18639 0.0789473684210526 1.11901140684411 0.507988521408201 0.999999999999966 GO:0030246 carbohydrate binding 20/1315 280/18639 0.0714285714285714 1.01243889190657 0.51075577986649 0.999999999999966 GO:0033192 calmodulin-dependent protein phosphatase activity 6/1315 81/18639 0.0740740740740741 1.04993662864385 0.512094580668116 0.999999999999966 GO:0140791 histone H2AXS140 phosphatase activity 6/1315 81/18639 0.0740740740740741 1.04993662864385 0.512094580668116 0.999999999999966 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 6/1315 81/18639 0.0740740740740741 1.04993662864385 0.512094580668116 0.999999999999966 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 6/1315 81/18639 0.0740740740740741 1.04993662864385 0.512094580668116 0.999999999999966 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 6/1315 81/18639 0.0740740740740741 1.04993662864385 0.512094580668116 0.999999999999966 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 6/1315 81/18639 0.0740740740740741 1.04993662864385 0.512094580668116 0.999999999999966 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 6/1315 81/18639 0.0740740740740741 1.04993662864385 0.512094580668116 0.999999999999966 GO:1990439 MAP kinase serine/threonine phosphatase activity 6/1315 81/18639 0.0740740740740741 1.04993662864385 0.512094580668116 0.999999999999966 GO:0005315 phosphate transmembrane transporter activity 2/1315 24/18639 0.0833333333333333 1.18117870722433 0.512677823041495 0.999999999999966 GO:0005540 hyaluronic acid binding 2/1315 24/18639 0.0833333333333333 1.18117870722433 0.512677823041495 0.999999999999966 GO:0015149 hexose transmembrane transporter activity 2/1315 24/18639 0.0833333333333333 1.18117870722433 0.512677823041495 0.999999999999966 GO:0055056 D-glucose transmembrane transporter activity 2/1315 24/18639 0.0833333333333333 1.18117870722433 0.512677823041495 0.999999999999966 GO:0003680 minor groove of adenine-thymine-rich DNA binding 1/1315 10/18639 0.1 1.4174144486692 0.518965693698493 0.999999999999966 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 1/1315 10/18639 0.1 1.4174144486692 0.518965693698493 0.999999999999966 GO:0004862 cAMP-dependent protein kinase inhibitor activity 1/1315 10/18639 0.1 1.4174144486692 0.518965693698493 0.999999999999966 GO:0005131 growth hormone receptor binding 1/1315 10/18639 0.1 1.4174144486692 0.518965693698493 0.999999999999966 GO:0008190 eukaryotic initiation factor 4E binding 1/1315 10/18639 0.1 1.4174144486692 0.518965693698493 0.999999999999966 GO:0008239 dipeptidyl-peptidase activity 1/1315 10/18639 0.1 1.4174144486692 0.518965693698493 0.999999999999966 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 1/1315 10/18639 0.1 1.4174144486692 0.518965693698493 0.999999999999966 GO:0015279 store-operated calcium channel activity 1/1315 10/18639 0.1 1.4174144486692 0.518965693698493 0.999999999999966 GO:0015658 branched-chain amino acid transmembrane transporter activity 1/1315 10/18639 0.1 1.4174144486692 0.518965693698493 0.999999999999966 GO:0015924 mannosyl-oligosaccharide mannosidase activity 1/1315 10/18639 0.1 1.4174144486692 0.518965693698493 0.999999999999966 GO:0019531 oxalate transmembrane transporter activity 1/1315 10/18639 0.1 1.4174144486692 0.518965693698493 0.999999999999966 GO:0019911 structural constituent of myelin sheath 1/1315 10/18639 0.1 1.4174144486692 0.518965693698493 0.999999999999966 GO:0030957 Tat protein binding 1/1315 10/18639 0.1 1.4174144486692 0.518965693698493 0.999999999999966 GO:0031996 thioesterase binding 1/1315 10/18639 0.1 1.4174144486692 0.518965693698493 0.999999999999966 GO:0032356 oxidized DNA binding 1/1315 10/18639 0.1 1.4174144486692 0.518965693698493 0.999999999999966 GO:0050815 phosphoserine residue binding 1/1315 10/18639 0.1 1.4174144486692 0.518965693698493 0.999999999999966 GO:0070097 delta-catenin binding 1/1315 10/18639 0.1 1.4174144486692 0.518965693698493 0.999999999999966 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 1/1315 10/18639 0.1 1.4174144486692 0.518965693698493 0.999999999999966 GO:0140940 histone H2A methyltransferase activity 1/1315 10/18639 0.1 1.4174144486692 0.518965693698493 0.999999999999966 GO:1990259 histone H2AQ104 methyltransferase activity 1/1315 10/18639 0.1 1.4174144486692 0.518965693698493 0.999999999999966 GO:1990757 ubiquitin ligase activator activity 1/1315 10/18639 0.1 1.4174144486692 0.518965693698493 0.999999999999966 GO:0051018 protein kinase A binding 4/1315 53/18639 0.0754716981132075 1.0697467537126 0.519812489474411 0.999999999999966 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 6/1315 82/18639 0.0731707317073171 1.03713252341649 0.52427746451238 0.999999999999966 GO:0033549 MAP kinase phosphatase activity 6/1315 82/18639 0.0731707317073171 1.03713252341649 0.52427746451238 0.999999999999966 GO:0032934 sterol binding 5/1315 68/18639 0.0735294117647059 1.04221650637441 0.528856143090112 0.999999999999966 GO:1990841 promoter-specific chromatin binding 5/1315 68/18639 0.0735294117647059 1.04221650637441 0.528856143090112 0.999999999999966 GO:0015485 cholesterol binding 4/1315 54/18639 0.0740740740740741 1.04993662864385 0.534796968855857 0.999999999999966 GO:0015662 P-type ion transporter activity 2/1315 25/18639 0.08 1.13393155893536 0.534896753194826 0.999999999999966 GO:0042974 nuclear retinoic acid receptor binding 2/1315 25/18639 0.08 1.13393155893536 0.534896753194826 0.999999999999966 GO:0120020 cholesterol transfer activity 2/1315 25/18639 0.08 1.13393155893536 0.534896753194826 0.999999999999966 GO:0140358 P-type transmembrane transporter activity 2/1315 25/18639 0.08 1.13393155893536 0.534896753194826 0.999999999999966 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 6/1315 83/18639 0.072289156626506 1.02463695084521 0.536336267683767 0.999999999999966 GO:0005254 chloride channel activity 6/1315 83/18639 0.072289156626506 1.02463695084521 0.536336267683767 0.999999999999966 GO:0008237 metallopeptidase activity 13/1315 184/18639 0.0706521739130435 1.00143412134237 0.539336419818768 0.999999999999966 GO:0015144 carbohydrate transmembrane transporter activity 3/1315 40/18639 0.075 1.0630608365019 0.543117628103987 0.999999999999966 GO:0061791 GTPase motor activity 3/1315 40/18639 0.075 1.0630608365019 0.543117628103987 0.999999999999966 GO:0140662 ATP-dependent protein folding chaperone 3/1315 40/18639 0.075 1.0630608365019 0.543117628103987 0.999999999999966 GO:1990606 membrane scission GTPase motor activity 3/1315 40/18639 0.075 1.0630608365019 0.543117628103987 0.999999999999966 GO:0019001 guanyl nucleotide binding 28/1315 400/18639 0.07 0.992190114068441 0.545951534718992 0.999999999999966 GO:0032561 guanyl ribonucleotide binding 28/1315 400/18639 0.07 0.992190114068441 0.545951534718992 0.999999999999966 GO:0017018 myosin phosphatase activity 6/1315 84/18639 0.0714285714285714 1.01243889190657 0.548262874323297 0.999999999999966 GO:0020037 heme binding 10/1315 142/18639 0.0704225352112676 0.998179189203663 0.549495820758073 0.999999999999966 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 1/1315 11/18639 0.0909090909090909 1.28855858969927 0.552921360282125 0.999999999999966 GO:0008172 S-methyltransferase activity 1/1315 11/18639 0.0909090909090909 1.28855858969927 0.552921360282125 0.999999999999966 GO:0008199 ferric iron binding 1/1315 11/18639 0.0909090909090909 1.28855858969927 0.552921360282125 0.999999999999966 GO:0008432 JUN kinase binding 1/1315 11/18639 0.0909090909090909 1.28855858969927 0.552921360282125 0.999999999999966 GO:0008526 phosphatidylinositol transfer activity 1/1315 11/18639 0.0909090909090909 1.28855858969927 0.552921360282125 0.999999999999966 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 1/1315 11/18639 0.0909090909090909 1.28855858969927 0.552921360282125 0.999999999999966 GO:0019107 myristoyltransferase activity 1/1315 11/18639 0.0909090909090909 1.28855858969927 0.552921360282125 0.999999999999966 GO:0019206 nucleoside kinase activity 1/1315 11/18639 0.0909090909090909 1.28855858969927 0.552921360282125 0.999999999999966 GO:0019215 intermediate filament binding 1/1315 11/18639 0.0909090909090909 1.28855858969927 0.552921360282125 0.999999999999966 GO:0019864 IgG binding 1/1315 11/18639 0.0909090909090909 1.28855858969927 0.552921360282125 0.999999999999966 GO:0032794 GTPase activating protein binding 1/1315 11/18639 0.0909090909090909 1.28855858969927 0.552921360282125 0.999999999999966 GO:0042608 T cell receptor binding 1/1315 11/18639 0.0909090909090909 1.28855858969927 0.552921360282125 0.999999999999966 GO:0043522 leucine zipper domain binding 1/1315 11/18639 0.0909090909090909 1.28855858969927 0.552921360282125 0.999999999999966 GO:0050786 RAGE receptor binding 1/1315 11/18639 0.0909090909090909 1.28855858969927 0.552921360282125 0.999999999999966 GO:0070697 activin receptor binding 1/1315 11/18639 0.0909090909090909 1.28855858969927 0.552921360282125 0.999999999999966 GO:0180030 inositol phosphate kinase activity 1/1315 11/18639 0.0909090909090909 1.28855858969927 0.552921360282125 0.999999999999966 GO:0004435 phosphatidylinositol phospholipase C activity 2/1315 26/18639 0.0769230769230769 1.09031880666862 0.55640888287448 0.999999999999966 GO:0005227 calcium-activated cation channel activity 2/1315 26/18639 0.0769230769230769 1.09031880666862 0.55640888287448 0.999999999999966 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 2/1315 26/18639 0.0769230769230769 1.09031880666862 0.55640888287448 0.999999999999966 GO:0008143 poly(A) binding 2/1315 26/18639 0.0769230769230769 1.09031880666862 0.55640888287448 0.999999999999966 GO:0015145 monosaccharide transmembrane transporter activity 2/1315 26/18639 0.0769230769230769 1.09031880666862 0.55640888287448 0.999999999999966 GO:0034237 protein kinase A regulatory subunit binding 2/1315 26/18639 0.0769230769230769 1.09031880666862 0.55640888287448 0.999999999999966 GO:0050681 nuclear androgen receptor binding 2/1315 26/18639 0.0769230769230769 1.09031880666862 0.55640888287448 0.999999999999966 GO:0051139 metal cation:proton antiporter activity 2/1315 26/18639 0.0769230769230769 1.09031880666862 0.55640888287448 0.999999999999966 GO:0140297 DNA-binding transcription factor binding 34/1315 488/18639 0.069672131147541 0.987542853581001 0.556677111896658 0.999999999999966 GO:0001530 lipopolysaccharide binding 3/1315 41/18639 0.0731707317073171 1.03713252341649 0.560126208369366 0.999999999999966 GO:0140828 metal cation:monoatomic cation antiporter activity 3/1315 41/18639 0.0731707317073171 1.03713252341649 0.560126208369366 0.999999999999966 GO:0005085 guanyl-nucleotide exchange factor activity 16/1315 230/18639 0.0695652173913043 0.986027442552488 0.560723007598016 0.999999999999966 GO:0008234 cysteine-type peptidase activity 13/1315 187/18639 0.0695187165775401 0.985368333299445 0.563339374797044 0.999999999999966 GO:0050660 flavin adenine dinucleotide binding 6/1315 86/18639 0.0697674418604651 0.988893801397117 0.571689640152619 0.999999999999966 GO:0008194 UDP-glycosyltransferase activity 10/1315 145/18639 0.0689655172413793 0.97752720597876 0.5765772299042 0.999999999999966 GO:0004520 DNA endonuclease activity 3/1315 42/18639 0.0714285714285714 1.01243889190657 0.576745617483059 0.999999999999966 GO:0031492 nucleosomal DNA binding 3/1315 42/18639 0.0714285714285714 1.01243889190657 0.576745617483059 0.999999999999966 GO:0048487 beta-tubulin binding 3/1315 42/18639 0.0714285714285714 1.01243889190657 0.576745617483059 0.999999999999966 GO:0051879 Hsp90 protein binding 3/1315 42/18639 0.0714285714285714 1.01243889190657 0.576745617483059 0.999999999999966 GO:0005104 fibroblast growth factor receptor binding 2/1315 27/18639 0.0740740740740741 1.04993662864385 0.577203286635094 0.999999999999966 GO:0023026 MHC class II protein complex binding 2/1315 27/18639 0.0740740740740741 1.04993662864385 0.577203286635094 0.999999999999966 GO:0035255 ionotropic glutamate receptor binding 2/1315 27/18639 0.0740740740740741 1.04993662864385 0.577203286635094 0.999999999999966 GO:0000340 RNA 7-methylguanosine cap binding 1/1315 12/18639 0.0833333333333333 1.18117870722433 0.584481828997446 0.999999999999966 GO:0000995 RNA polymerase III general transcription initiation factor activity 1/1315 12/18639 0.0833333333333333 1.18117870722433 0.584481828997446 0.999999999999966 GO:0005049 nuclear export signal receptor activity 1/1315 12/18639 0.0833333333333333 1.18117870722433 0.584481828997446 0.999999999999966 GO:0005078 MAP-kinase scaffold activity 1/1315 12/18639 0.0833333333333333 1.18117870722433 0.584481828997446 0.999999999999966 GO:0005165 neurotrophin receptor binding 1/1315 12/18639 0.0833333333333333 1.18117870722433 0.584481828997446 0.999999999999966 GO:0005247 voltage-gated chloride channel activity 1/1315 12/18639 0.0833333333333333 1.18117870722433 0.584481828997446 0.999999999999966 GO:0008179 adenylate cyclase binding 1/1315 12/18639 0.0833333333333333 1.18117870722433 0.584481828997446 0.999999999999966 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 1/1315 12/18639 0.0833333333333333 1.18117870722433 0.584481828997446 0.999999999999966 GO:0015269 calcium-activated potassium channel activity 1/1315 12/18639 0.0833333333333333 1.18117870722433 0.584481828997446 0.999999999999966 GO:0016273 arginine N-methyltransferase activity 1/1315 12/18639 0.0833333333333333 1.18117870722433 0.584481828997446 0.999999999999966 GO:0016274 protein-arginine N-methyltransferase activity 1/1315 12/18639 0.0833333333333333 1.18117870722433 0.584481828997446 0.999999999999966 GO:0016423 tRNA (guanine) methyltransferase activity 1/1315 12/18639 0.0833333333333333 1.18117870722433 0.584481828997446 0.999999999999966 GO:0035259 nuclear glucocorticoid receptor binding 1/1315 12/18639 0.0833333333333333 1.18117870722433 0.584481828997446 0.999999999999966 GO:0035497 cAMP response element binding 1/1315 12/18639 0.0833333333333333 1.18117870722433 0.584481828997446 0.999999999999966 GO:0036009 protein-glutamine N-methyltransferase activity 1/1315 12/18639 0.0833333333333333 1.18117870722433 0.584481828997446 0.999999999999966 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 1/1315 12/18639 0.0833333333333333 1.18117870722433 0.584481828997446 0.999999999999966 GO:0140829 bicarbonate:monoatomic anion antiporter activity 1/1315 12/18639 0.0833333333333333 1.18117870722433 0.584481828997446 0.999999999999966 GO:0140900 chloride:bicarbonate antiporter activity 1/1315 12/18639 0.0833333333333333 1.18117870722433 0.584481828997446 0.999999999999966 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 1/1315 12/18639 0.0833333333333333 1.18117870722433 0.584481828997446 0.999999999999966 GO:1990459 transferrin receptor binding 1/1315 12/18639 0.0833333333333333 1.18117870722433 0.584481828997446 0.999999999999966 GO:0008238 exopeptidase activity 7/1315 102/18639 0.0686274509803922 0.972735405949452 0.585916703992368 0.999999999999966 GO:0008408 3'-5' exonuclease activity 4/1315 58/18639 0.0689655172413793 0.97752720597876 0.592245823394039 0.999999999999966 GO:0004712 protein serine/threonine/tyrosine kinase activity 3/1315 43/18639 0.0697674418604651 0.988893801397117 0.592964889992425 0.999999999999966 GO:0008375 acetylglucosaminyltransferase activity 3/1315 43/18639 0.0697674418604651 0.988893801397117 0.592964889992425 0.999999999999966 GO:0004722 protein serine/threonine phosphatase activity 7/1315 103/18639 0.0679611650485437 0.963291372881982 0.59637709641983 0.999999999999966 GO:0019789 SUMO transferase activity 2/1315 28/18639 0.0714285714285714 1.01243889190657 0.597274094029169 0.999999999999966 GO:0046875 ephrin receptor binding 2/1315 28/18639 0.0714285714285714 1.01243889190657 0.597274094029169 0.999999999999966 GO:0031491 nucleosome binding 5/1315 74/18639 0.0675675675675676 0.957712465317028 0.605250576447253 0.999999999999966 GO:0001786 phosphatidylserine binding 4/1315 59/18639 0.0677966101694915 0.960958948250306 0.605936255522974 0.999999999999966 GO:0001046 core promoter sequence-specific DNA binding 3/1315 44/18639 0.0681818181818182 0.966418942274456 0.608775211068857 0.999999999999966 GO:0002161 aminoacyl-tRNA editing activity 1/1315 13/18639 0.0769230769230769 1.09031880666862 0.613815935126633 0.999999999999966 GO:0004535 poly(A)-specific ribonuclease activity 1/1315 13/18639 0.0769230769230769 1.09031880666862 0.613815935126633 0.999999999999966 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 1/1315 13/18639 0.0769230769230769 1.09031880666862 0.613815935126633 0.999999999999966 GO:0005172 vascular endothelial growth factor receptor binding 1/1315 13/18639 0.0769230769230769 1.09031880666862 0.613815935126633 0.999999999999966 GO:0008035 high-density lipoprotein particle binding 1/1315 13/18639 0.0769230769230769 1.09031880666862 0.613815935126633 0.999999999999966 GO:0009982 pseudouridine synthase activity 1/1315 13/18639 0.0769230769230769 1.09031880666862 0.613815935126633 0.999999999999966 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 1/1315 13/18639 0.0769230769230769 1.09031880666862 0.613815935126633 0.999999999999966 GO:0019104 DNA N-glycosylase activity 1/1315 13/18639 0.0769230769230769 1.09031880666862 0.613815935126633 0.999999999999966 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 1/1315 13/18639 0.0769230769230769 1.09031880666862 0.613815935126633 0.999999999999966 GO:0089720 caspase binding 1/1315 13/18639 0.0769230769230769 1.09031880666862 0.613815935126633 0.999999999999966 GO:0140410 monoatomic cation:bicarbonate symporter activity 1/1315 13/18639 0.0769230769230769 1.09031880666862 0.613815935126633 0.999999999999966 GO:0016757 glycosyltransferase activity 18/1315 267/18639 0.0674157303370786 0.955560302473619 0.614566411335226 0.999999999999966 GO:0004629 phospholipase C activity 2/1315 29/18639 0.0689655172413793 0.97752720597876 0.616619831688251 0.999999999999966 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 2/1315 29/18639 0.0689655172413793 0.97752720597876 0.616619831688251 0.999999999999966 GO:0005416 amino acid:monoatomic cation symporter activity 2/1315 29/18639 0.0689655172413793 0.97752720597876 0.616619831688251 0.999999999999966 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 2/1315 29/18639 0.0689655172413793 0.97752720597876 0.616619831688251 0.999999999999966 GO:0097472 cyclin-dependent protein kinase activity 2/1315 29/18639 0.0689655172413793 0.97752720597876 0.616619831688251 0.999999999999966 GO:0019003 GDP binding 5/1315 75/18639 0.0666666666666667 0.944942965779468 0.617274749760914 0.999999999999966 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 4/1315 60/18639 0.0666666666666667 0.944942965779468 0.619342360660642 0.999999999999966 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 4/1315 60/18639 0.0666666666666667 0.944942965779468 0.619342360660642 0.999999999999966 GO:0046915 transition metal ion transmembrane transporter activity 3/1315 45/18639 0.0666666666666667 0.944942965779468 0.624169761937902 0.999999999999966 GO:0140303 intramembrane lipid transporter activity 3/1315 45/18639 0.0666666666666667 0.944942965779468 0.624169761937902 0.999999999999966 GO:0098631 cell adhesion mediator activity 5/1315 76/18639 0.0657894736842105 0.932509505703422 0.629080032040219 0.999999999999966 GO:0001965 G-protein alpha-subunit binding 2/1315 30/18639 0.0666666666666667 0.944942965779468 0.635242832963267 0.999999999999966 GO:0016769 transferase activity, transferring nitrogenous groups 2/1315 30/18639 0.0666666666666667 0.944942965779468 0.635242832963267 0.999999999999966 GO:0048019 receptor antagonist activity 2/1315 30/18639 0.0666666666666667 0.944942965779468 0.635242832963267 0.999999999999966 GO:0005344 oxygen carrier activity 1/1315 14/18639 0.0714285714285714 1.01243889190657 0.64108062133454 0.999999999999966 GO:0008174 mRNA methyltransferase activity 1/1315 14/18639 0.0714285714285714 1.01243889190657 0.64108062133454 0.999999999999966 GO:0008331 high voltage-gated calcium channel activity 1/1315 14/18639 0.0714285714285714 1.01243889190657 0.64108062133454 0.999999999999966 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 1/1315 14/18639 0.0714285714285714 1.01243889190657 0.64108062133454 0.999999999999966 GO:0019992 diacylglycerol binding 1/1315 14/18639 0.0714285714285714 1.01243889190657 0.64108062133454 0.999999999999966 GO:0031404 chloride ion binding 1/1315 14/18639 0.0714285714285714 1.01243889190657 0.64108062133454 0.999999999999966 GO:0034236 protein kinase A catalytic subunit binding 1/1315 14/18639 0.0714285714285714 1.01243889190657 0.64108062133454 0.999999999999966 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 1/1315 14/18639 0.0714285714285714 1.01243889190657 0.64108062133454 0.999999999999966 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 1/1315 14/18639 0.0714285714285714 1.01243889190657 0.64108062133454 0.999999999999966 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 1/1315 14/18639 0.0714285714285714 1.01243889190657 0.64108062133454 0.999999999999966 GO:1901474 azole transmembrane transporter activity 1/1315 14/18639 0.0714285714285714 1.01243889190657 0.64108062133454 0.999999999999966 GO:0015291 secondary active transmembrane transporter activity 19/1315 287/18639 0.0662020905923345 0.938357997376823 0.647504898752595 0.999999999999966 GO:0005310 dicarboxylic acid transmembrane transporter activity 2/1315 31/18639 0.0645161290322581 0.914460934625291 0.653148708877183 0.999999999999966 GO:0005452 solute:inorganic anion antiporter activity 2/1315 31/18639 0.0645161290322581 0.914460934625291 0.653148708877183 0.999999999999966 GO:0016878 acid-thiol ligase activity 2/1315 31/18639 0.0645161290322581 0.914460934625291 0.653148708877183 0.999999999999966 GO:0047499 calcium-independent phospholipase A2 activity 2/1315 31/18639 0.0645161290322581 0.914460934625291 0.653148708877183 0.999999999999966 GO:0072349 modified amino acid transmembrane transporter activity 2/1315 31/18639 0.0645161290322581 0.914460934625291 0.653148708877183 0.999999999999966 GO:0030295 protein kinase activator activity 9/1315 139/18639 0.0647482014388489 0.917750362447684 0.6535368938518 0.999999999999966 GO:0070851 growth factor receptor binding 9/1315 139/18639 0.0647482014388489 0.917750362447684 0.6535368938518 0.999999999999966 GO:1901682 sulfur compound transmembrane transporter activity 4/1315 63/18639 0.0634920634920635 0.899945681694731 0.657801196996988 0.999999999999966 GO:0042562 hormone binding 6/1315 94/18639 0.0638297872340425 0.904732626810129 0.658837699171278 0.999999999999966 GO:0000774 adenyl-nucleotide exchange factor activity 1/1315 15/18639 0.0666666666666667 0.944942965779468 0.666421774781256 0.999999999999966 GO:0004089 carbonate dehydratase activity 1/1315 15/18639 0.0666666666666667 0.944942965779468 0.666421774781256 0.999999999999966 GO:0004559 alpha-mannosidase activity 1/1315 15/18639 0.0666666666666667 0.944942965779468 0.666421774781256 0.999999999999966 GO:0005402 carbohydrate:monoatomic cation symporter activity 1/1315 15/18639 0.0666666666666667 0.944942965779468 0.666421774781256 0.999999999999966 GO:0005523 tropomyosin binding 1/1315 15/18639 0.0666666666666667 0.944942965779468 0.666421774781256 0.999999999999966 GO:0008242 omega peptidase activity 1/1315 15/18639 0.0666666666666667 0.944942965779468 0.666421774781256 0.999999999999966 GO:0010181 FMN binding 1/1315 15/18639 0.0666666666666667 0.944942965779468 0.666421774781256 0.999999999999966 GO:0015116 sulfate transmembrane transporter activity 1/1315 15/18639 0.0666666666666667 0.944942965779468 0.666421774781256 0.999999999999966 GO:0015556 C4-dicarboxylate transmembrane transporter activity 1/1315 15/18639 0.0666666666666667 0.944942965779468 0.666421774781256 0.999999999999966 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 1/1315 15/18639 0.0666666666666667 0.944942965779468 0.666421774781256 0.999999999999966 GO:0031005 filamin binding 1/1315 15/18639 0.0666666666666667 0.944942965779468 0.666421774781256 0.999999999999966 GO:0034483 heparan sulfate sulfotransferase activity 1/1315 15/18639 0.0666666666666667 0.944942965779468 0.666421774781256 0.999999999999966 GO:0048531 beta-1,3-galactosyltransferase activity 1/1315 15/18639 0.0666666666666667 0.944942965779468 0.666421774781256 0.999999999999966 GO:0050780 dopamine receptor binding 1/1315 15/18639 0.0666666666666667 0.944942965779468 0.666421774781256 0.999999999999966 GO:0061578 K63-linked deubiquitinase activity 1/1315 15/18639 0.0666666666666667 0.944942965779468 0.666421774781256 0.999999999999966 GO:0140161 monocarboxylate:sodium symporter activity 1/1315 15/18639 0.0666666666666667 0.944942965779468 0.666421774781256 0.999999999999966 GO:0005543 phospholipid binding 33/1315 497/18639 0.0663983903420523 0.941140378392025 0.66852246874814 0.999999999999966 GO:0015106 bicarbonate transmembrane transporter activity 2/1315 32/18639 0.0625 0.885884030418251 0.670345874687349 0.999999999999966 GO:0042910 xenobiotic transmembrane transporter activity 2/1315 32/18639 0.0625 0.885884030418251 0.670345874687349 0.999999999999966 GO:0051059 NF-kappaB binding 2/1315 32/18639 0.0625 0.885884030418251 0.670345874687349 0.999999999999966 GO:0070717 poly-purine tract binding 2/1315 32/18639 0.0625 0.885884030418251 0.670345874687349 0.999999999999966 GO:0120015 sterol transfer activity 2/1315 32/18639 0.0625 0.885884030418251 0.670345874687349 0.999999999999966 GO:1902936 phosphatidylinositol bisphosphate binding 7/1315 111/18639 0.0630630630630631 0.893864967629226 0.674817139502186 0.999999999999966 GO:0042393 histone binding 16/1315 247/18639 0.0647773279352227 0.918163205615677 0.675206303594584 0.999999999999966 GO:0042826 histone deacetylase binding 8/1315 127/18639 0.062992125984252 0.892859495224694 0.680687625436422 0.999999999999966 GO:0016763 pentosyltransferase activity 3/1315 49/18639 0.0612244897959184 0.867804764491348 0.681515489443469 0.999999999999966 GO:0001618 virus receptor activity 5/1315 81/18639 0.0617283950617284 0.874947190536544 0.684682335158073 0.999999999999966 GO:0015101 organic cation transmembrane transporter activity 5/1315 81/18639 0.0617283950617284 0.874947190536544 0.684682335158073 0.999999999999966 GO:0140311 protein sequestering activity 2/1315 33/18639 0.0606060606060606 0.859039059799516 0.686845126853412 0.999999999999966 GO:0140104 molecular carrier activity 16/1315 249/18639 0.0642570281124498 0.910788400751294 0.687535840366605 0.999999999999966 GO:0004708 MAP kinase kinase activity 1/1315 16/18639 0.0625 0.885884030418251 0.689975005352704 0.999999999999966 GO:0005149 interleukin-1 receptor binding 1/1315 16/18639 0.0625 0.885884030418251 0.689975005352704 0.999999999999966 GO:0005324 long-chain fatty acid transmembrane transporter activity 1/1315 16/18639 0.0625 0.885884030418251 0.689975005352704 0.999999999999966 GO:0015378 sodium:chloride symporter activity 1/1315 16/18639 0.0625 0.885884030418251 0.689975005352704 0.999999999999966 GO:0015385 sodium:proton antiporter activity 1/1315 16/18639 0.0625 0.885884030418251 0.689975005352704 0.999999999999966 GO:0015923 mannosidase activity 1/1315 16/18639 0.0625 0.885884030418251 0.689975005352704 0.999999999999966 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 1/1315 16/18639 0.0625 0.885884030418251 0.689975005352704 0.999999999999966 GO:0016722 oxidoreductase activity, acting on metal ions 1/1315 16/18639 0.0625 0.885884030418251 0.689975005352704 0.999999999999966 GO:0022858 alanine transmembrane transporter activity 1/1315 16/18639 0.0625 0.885884030418251 0.689975005352704 0.999999999999966 GO:0019903 protein phosphatase binding 9/1315 144/18639 0.0625 0.885884030418251 0.694382735842421 0.999999999999966 GO:0140272 exogenous protein binding 5/1315 82/18639 0.0609756097560976 0.864277102847074 0.695098235849352 0.999999999999966 GO:0004721 phosphoprotein phosphatase activity 11/1315 175/18639 0.0628571428571429 0.890946224877784 0.697599019585482 0.999999999999966 GO:0008376 acetylgalactosaminyltransferase activity 2/1315 34/18639 0.0588235294117647 0.83377320509953 0.702659265663398 0.999999999999966 GO:0090482 vitamin transmembrane transporter activity 2/1315 34/18639 0.0588235294117647 0.83377320509953 0.702659265663398 0.999999999999966 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 8/1315 130/18639 0.0615384615384615 0.872255045334893 0.705638723696918 0.999999999999966 GO:0001221 transcription coregulator binding 7/1315 115/18639 0.0608695652173913 0.862774012233427 0.710238330900268 0.999999999999966 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 17/1315 268/18639 0.0634328358208955 0.899106180125986 0.710816754047708 0.999999999999966 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 1/1315 17/18639 0.0588235294117647 0.83377320509953 0.711866369148075 0.999999999999966 GO:0017110 nucleoside diphosphate phosphatase activity 1/1315 17/18639 0.0588235294117647 0.83377320509953 0.711866369148075 0.999999999999966 GO:0019198 transmembrane receptor protein phosphatase activity 1/1315 17/18639 0.0588235294117647 0.83377320509953 0.711866369148075 0.999999999999966 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 1/1315 17/18639 0.0588235294117647 0.83377320509953 0.711866369148075 0.999999999999966 GO:0030548 acetylcholine receptor regulator activity 1/1315 17/18639 0.0588235294117647 0.83377320509953 0.711866369148075 0.999999999999966 GO:0032183 SUMO binding 1/1315 17/18639 0.0588235294117647 0.83377320509953 0.711866369148075 0.999999999999966 GO:0032977 membrane insertase activity 1/1315 17/18639 0.0588235294117647 0.83377320509953 0.711866369148075 0.999999999999966 GO:0036041 long-chain fatty acid binding 1/1315 17/18639 0.0588235294117647 0.83377320509953 0.711866369148075 0.999999999999966 GO:0038191 neuropilin binding 1/1315 17/18639 0.0588235294117647 0.83377320509953 0.711866369148075 0.999999999999966 GO:1990226 histone methyltransferase binding 1/1315 17/18639 0.0588235294117647 0.83377320509953 0.711866369148075 0.999999999999966 GO:0015085 calcium ion transmembrane transporter activity 9/1315 147/18639 0.0612244897959184 0.867804764491348 0.717387309174456 0.999999999999966 GO:0004623 phospholipase A2 activity 2/1315 35/18639 0.0571428571428571 0.809951113525258 0.717802759188725 0.999999999999966 GO:0005154 epidermal growth factor receptor binding 2/1315 35/18639 0.0571428571428571 0.809951113525258 0.717802759188725 0.999999999999966 GO:0005343 organic acid:sodium symporter activity 2/1315 35/18639 0.0571428571428571 0.809951113525258 0.717802759188725 0.999999999999966 GO:0140566 histone reader activity 2/1315 35/18639 0.0571428571428571 0.809951113525258 0.717802759188725 0.999999999999966 GO:0015294 solute:monoatomic cation symporter activity 7/1315 116/18639 0.0603448275862069 0.855336305231415 0.718677785547452 0.999999999999966 GO:0005179 hormone activity 8/1315 132/18639 0.0606060606060606 0.859039059799516 0.721550660313844 0.999999999999966 GO:0019209 kinase activator activity 9/1315 148/18639 0.0608108108108108 0.861941218785325 0.724798210836883 0.999999999999966 GO:0008509 monoatomic anion transmembrane transporter activity 9/1315 149/18639 0.0604026845637584 0.856156378390793 0.732079258400634 0.999999999999966 GO:0005246 calcium channel regulator activity 3/1315 53/18639 0.0566037735849057 0.802310065284454 0.732084999980166 0.999999999999966 GO:0000900 mRNA regulatory element binding translation repressor activity 1/1315 18/18639 0.0555555555555556 0.78745247148289 0.732213041072158 0.999999999999966 GO:0008525 phosphatidylcholine transporter activity 1/1315 18/18639 0.0555555555555556 0.78745247148289 0.732213041072158 0.999999999999966 GO:0015280 ligand-gated sodium channel activity 1/1315 18/18639 0.0555555555555556 0.78745247148289 0.732213041072158 0.999999999999966 GO:0015373 monoatomic anion:sodium symporter activity 1/1315 18/18639 0.0555555555555556 0.78745247148289 0.732213041072158 0.999999999999966 GO:0016854 racemase and epimerase activity 1/1315 18/18639 0.0555555555555556 0.78745247148289 0.732213041072158 0.999999999999966 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 1/1315 18/18639 0.0555555555555556 0.78745247148289 0.732213041072158 0.999999999999966 GO:0017075 syntaxin-1 binding 1/1315 18/18639 0.0555555555555556 0.78745247148289 0.732213041072158 0.999999999999966 GO:0032393 MHC class I receptor activity 1/1315 18/18639 0.0555555555555556 0.78745247148289 0.732213041072158 0.999999999999966 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 1/1315 18/18639 0.0555555555555556 0.78745247148289 0.732213041072158 0.999999999999966 GO:0099602 neurotransmitter receptor regulator activity 1/1315 18/18639 0.0555555555555556 0.78745247148289 0.732213041072158 0.999999999999966 GO:0000993 RNA polymerase II complex binding 2/1315 36/18639 0.0555555555555556 0.78745247148289 0.732291444621846 0.999999999999966 GO:0004869 cysteine-type endopeptidase inhibitor activity 2/1315 36/18639 0.0555555555555556 0.78745247148289 0.732291444621846 0.999999999999966 GO:0015171 amino acid transmembrane transporter activity 6/1315 102/18639 0.0588235294117647 0.83377320509953 0.734048326931906 0.999999999999966 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 5/1315 86/18639 0.0581395348837209 0.824078167830931 0.734368548567465 0.999999999999966 GO:0016782 transferase activity, transferring sulphur-containing groups 4/1315 70/18639 0.0571428571428571 0.809951113525258 0.736941200924397 0.999999999999966 GO:0097110 scaffold protein binding 4/1315 70/18639 0.0571428571428571 0.809951113525258 0.736941200924397 0.999999999999966 GO:0016791 phosphatase activity 17/1315 273/18639 0.0622710622710623 0.882639033969832 0.738308407656222 0.999999999999966 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 11/1315 181/18639 0.0607734806629834 0.86141209587631 0.738420870554975 0.999999999999966 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 22/1315 349/18639 0.0630372492836676 0.893499079390328 0.739625991750026 0.999999999999966 GO:0016758 hexosyltransferase activity 12/1315 197/18639 0.0609137055837563 0.863399664163981 0.741793711567593 0.999999999999966 GO:0003925 G protein activity 3/1315 54/18639 0.0555555555555556 0.78745247148289 0.743690178281596 0.999999999999966 GO:0016874 ligase activity 10/1315 167/18639 0.0598802395209581 0.848751166867785 0.748580159049821 0.999999999999966 GO:0003756 protein disulfide isomerase activity 1/1315 19/18639 0.0526315789473684 0.746007604562738 0.751123940110347 0.999999999999966 GO:0015245 fatty acid transmembrane transporter activity 1/1315 19/18639 0.0526315789473684 0.746007604562738 0.751123940110347 0.999999999999966 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 1/1315 19/18639 0.0526315789473684 0.746007604562738 0.751123940110347 0.999999999999966 GO:0042577 lipid phosphatase activity 1/1315 19/18639 0.0526315789473684 0.746007604562738 0.751123940110347 0.999999999999966 GO:0140036 ubiquitin-modified protein reader activity 1/1315 19/18639 0.0526315789473684 0.746007604562738 0.751123940110347 0.999999999999966 GO:0016779 nucleotidyltransferase activity 8/1315 136/18639 0.0588235294117647 0.83377320509953 0.751614450933614 0.999999999999966 GO:0015108 chloride transmembrane transporter activity 7/1315 121/18639 0.0578512396694215 0.819991829808629 0.758347368712817 0.999999999999966 GO:0030695 GTPase regulator activity 31/1315 489/18639 0.0633946830265849 0.898565396906856 0.75923658814354 0.999999999999966 GO:0005109 frizzled binding 2/1315 38/18639 0.0526315789473684 0.746007604562738 0.759373026844706 0.999999999999966 GO:0003774 cytoskeletal motor activity 9/1315 153/18639 0.0588235294117647 0.83377320509953 0.759897136911844 0.999999999999966 GO:0030414 peptidase inhibitor activity 10/1315 169/18639 0.0591715976331361 0.838706774360474 0.761530021421275 0.999999999999966 GO:0060589 nucleoside-triphosphatase regulator activity 31/1315 490/18639 0.063265306122449 0.896731589974393 0.763067419008947 0.999999999999966 GO:0001217 DNA-binding transcription repressor activity 17/1315 278/18639 0.0611510791366906 0.866764231200591 0.764084034366306 0.999999999999966 GO:0030170 pyridoxal phosphate binding 3/1315 56/18639 0.0535714285714286 0.759329168929929 0.765693770751568 0.999999999999966 GO:0000149 SNARE binding 6/1315 106/18639 0.0566037735849057 0.802310065284454 0.766928342626508 0.999999999999966 GO:0005326 neurotransmitter transmembrane transporter activity 1/1315 20/18639 0.05 0.708707224334601 0.768700310612758 0.999999999999966 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 1/1315 20/18639 0.05 0.708707224334601 0.768700310612758 0.999999999999966 GO:0030627 pre-mRNA 5'-splice site binding 1/1315 20/18639 0.05 0.708707224334601 0.768700310612758 0.999999999999966 GO:0030742 GTP-dependent protein binding 1/1315 20/18639 0.05 0.708707224334601 0.768700310612758 0.999999999999966 GO:0042288 MHC class I protein binding 1/1315 20/18639 0.05 0.708707224334601 0.768700310612758 0.999999999999966 GO:0140939 histone H4 methyltransferase activity 1/1315 20/18639 0.05 0.708707224334601 0.768700310612758 0.999999999999966 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 2/1315 39/18639 0.0512820512820513 0.726879204445744 0.772002209321052 0.999999999999966 GO:0003684 damaged DNA binding 4/1315 74/18639 0.0540540540540541 0.766169972253622 0.775524243547272 0.999999999999966 GO:0070279 vitamin B6 binding 3/1315 57/18639 0.0526315789473684 0.746007604562738 0.776105757770698 0.999999999999966 GO:0004177 aminopeptidase activity 2/1315 40/18639 0.05 0.708707224334601 0.784048766227213 0.999999999999966 GO:0071855 neuropeptide receptor binding 2/1315 40/18639 0.05 0.708707224334601 0.784048766227213 0.999999999999966 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 1/1315 21/18639 0.0476190476190476 0.674959261271048 0.785036262680228 0.999999999999966 GO:0001846 opsonin binding 1/1315 21/18639 0.0476190476190476 0.674959261271048 0.785036262680228 0.999999999999966 GO:0005123 death receptor binding 1/1315 21/18639 0.0476190476190476 0.674959261271048 0.785036262680228 0.999999999999966 GO:0005248 voltage-gated sodium channel activity 1/1315 21/18639 0.0476190476190476 0.674959261271048 0.785036262680228 0.999999999999966 GO:0009975 cyclase activity 1/1315 21/18639 0.0476190476190476 0.674959261271048 0.785036262680228 0.999999999999966 GO:0015174 basic amino acid transmembrane transporter activity 1/1315 21/18639 0.0476190476190476 0.674959261271048 0.785036262680228 0.999999999999966 GO:0019200 carbohydrate kinase activity 1/1315 21/18639 0.0476190476190476 0.674959261271048 0.785036262680228 0.999999999999966 GO:0061891 calcium ion sensor activity 1/1315 21/18639 0.0476190476190476 0.674959261271048 0.785036262680228 0.999999999999966 GO:0070182 DNA polymerase binding 1/1315 21/18639 0.0476190476190476 0.674959261271048 0.785036262680228 0.999999999999966 GO:1904047 S-adenosyl-L-methionine binding 1/1315 21/18639 0.0476190476190476 0.674959261271048 0.785036262680228 0.999999999999966 GO:0008514 organic anion transmembrane transporter activity 16/1315 269/18639 0.0594795539033457 0.843071791030008 0.795166207055583 0.999999999999966 GO:0003924 GTPase activity 20/1315 331/18639 0.0604229607250755 0.856443775630938 0.795483732414487 0.999999999999966 GO:0016877 ligase activity, forming carbon-sulfur bonds 2/1315 41/18639 0.0487804878048781 0.691421682277659 0.795531974322487 0.999999999999966 GO:0042169 SH2 domain binding 2/1315 41/18639 0.0487804878048781 0.691421682277659 0.795531974322487 0.999999999999966 GO:0042287 MHC protein binding 2/1315 41/18639 0.0487804878048781 0.691421682277659 0.795531974322487 0.999999999999966 GO:0004879 nuclear receptor activity 3/1315 59/18639 0.0508474576271186 0.72071921118773 0.795787957853666 0.999999999999966 GO:0015459 potassium channel regulator activity 3/1315 59/18639 0.0508474576271186 0.72071921118773 0.795787957853666 0.999999999999966 GO:0031593 polyubiquitin modification-dependent protein binding 3/1315 59/18639 0.0508474576271186 0.72071921118773 0.795787957853666 0.999999999999966 GO:0036002 pre-mRNA binding 3/1315 59/18639 0.0508474576271186 0.72071921118773 0.795787957853666 0.999999999999966 GO:0070888 E-box binding 3/1315 59/18639 0.0508474576271186 0.72071921118773 0.795787957853666 0.999999999999966 GO:0008649 rRNA methyltransferase activity 1/1315 22/18639 0.0454545454545455 0.644279294849637 0.800219274527661 0.999999999999966 GO:0015377 chloride:monoatomic cation symporter activity 1/1315 22/18639 0.0454545454545455 0.644279294849637 0.800219274527661 0.999999999999966 GO:0030021 extracellular matrix structural constituent conferring compression resistance 1/1315 22/18639 0.0454545454545455 0.644279294849637 0.800219274527661 0.999999999999966 GO:0140035 ubiquitin-like protein reader activity 1/1315 22/18639 0.0454545454545455 0.644279294849637 0.800219274527661 0.999999999999966 GO:0140784 metal ion sensor activity 1/1315 22/18639 0.0454545454545455 0.644279294849637 0.800219274527661 0.999999999999966 GO:0019783 ubiquitin-like protein peptidase activity 7/1315 127/18639 0.0551181102362205 0.781252058321607 0.800420244857029 0.999999999999966 GO:0004252 serine-type endopeptidase activity 10/1315 176/18639 0.0568181818181818 0.805349118562046 0.803152261676877 0.999999999999966 GO:0019955 cytokine binding 8/1315 144/18639 0.0555555555555556 0.78745247148289 0.804701131646387 0.999999999999966 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 3/1315 60/18639 0.05 0.708707224334601 0.805074568232247 0.999999999999966 GO:0098531 ligand-modulated transcription factor activity 3/1315 60/18639 0.05 0.708707224334601 0.805074568232247 0.999999999999966 GO:0042056 chemoattractant activity 2/1315 42/18639 0.0476190476190476 0.674959261271048 0.806471292164459 0.999999999999966 GO:0043175 RNA polymerase core enzyme binding 2/1315 42/18639 0.0476190476190476 0.674959261271048 0.806471292164459 0.999999999999966 GO:0004866 endopeptidase inhibitor activity 9/1315 161/18639 0.0559006211180124 0.792343480622535 0.80927838323847 0.999999999999966 GO:0005200 structural constituent of cytoskeleton 6/1315 112/18639 0.0535714285714286 0.759329168929929 0.810432449436191 0.999999999999966 GO:0005319 lipid transporter activity 10/1315 178/18639 0.0561797752808989 0.796300252061349 0.813999039493799 0.999999999999966 GO:0019905 syntaxin binding 3/1315 61/18639 0.0491803278688525 0.697089073116001 0.814002996959171 0.999999999999966 GO:0016493 C-C chemokine receptor activity 1/1315 23/18639 0.0434782608695652 0.616267151595305 0.814330659498178 0.999999999999966 GO:0043274 phospholipase binding 1/1315 23/18639 0.0434782608695652 0.616267151595305 0.814330659498178 0.999999999999966 GO:0099186 structural constituent of postsynapse 1/1315 23/18639 0.0434782608695652 0.616267151595305 0.814330659498178 0.999999999999966 GO:0140102 catalytic activity, acting on a rRNA 1/1315 23/18639 0.0434782608695652 0.616267151595305 0.814330659498178 0.999999999999966 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 1/1315 23/18639 0.0434782608695652 0.616267151595305 0.814330659498178 0.999999999999966 GO:0016407 acetyltransferase activity 5/1315 96/18639 0.0520833333333333 0.738236692015209 0.816068526462719 0.999999999999966 GO:0015293 symporter activity 8/1315 146/18639 0.0547945205479452 0.77666545132559 0.816533678032273 0.999999999999966 GO:0005245 voltage-gated calcium channel activity 2/1315 43/18639 0.0465116279069767 0.659262534264745 0.816886238611875 0.999999999999966 GO:0015179 L-amino acid transmembrane transporter activity 3/1315 62/18639 0.0483870967741935 0.685845700968968 0.822582174147374 0.999999999999966 GO:0005262 calcium channel activity 7/1315 131/18639 0.0534351145038168 0.757397033640031 0.825212147690454 0.999999999999966 GO:0031072 heat shock protein binding 7/1315 131/18639 0.0534351145038168 0.757397033640031 0.825212147690454 0.999999999999966 GO:0030020 extracellular matrix structural constituent conferring tensile strength 2/1315 44/18639 0.0454545454545455 0.644279294849637 0.826796287542495 0.999999999999966 GO:0019957 C-C chemokine binding 1/1315 24/18639 0.0416666666666667 0.590589353612167 0.827446000213686 0.999999999999966 GO:0035035 histone acetyltransferase binding 1/1315 24/18639 0.0416666666666667 0.590589353612167 0.827446000213686 0.999999999999966 GO:0050699 WW domain binding 1/1315 24/18639 0.0416666666666667 0.590589353612167 0.827446000213686 0.999999999999966 GO:0101005 deubiquitinase activity 6/1315 115/18639 0.0521739130434783 0.739520581914366 0.829667252125962 0.999999999999966 GO:0015103 inorganic anion transmembrane transporter activity 9/1315 165/18639 0.0545454545454545 0.773135153819564 0.830913648678076 0.999999999999966 GO:0000030 mannosyltransferase activity 1/1315 25/18639 0.04 0.566965779467681 0.839635552172805 0.999999999999966 GO:0001848 complement binding 1/1315 25/18639 0.04 0.566965779467681 0.839635552172805 0.999999999999966 GO:0005251 delayed rectifier potassium channel activity 1/1315 25/18639 0.04 0.566965779467681 0.839635552172805 0.999999999999966 GO:0005537 D-mannose binding 1/1315 25/18639 0.04 0.566965779467681 0.839635552172805 0.999999999999966 GO:0015296 monoatomic anion:monoatomic cation symporter activity 1/1315 25/18639 0.04 0.566965779467681 0.839635552172805 0.999999999999966 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 1/1315 25/18639 0.04 0.566965779467681 0.839635552172805 0.999999999999966 GO:0017056 structural constituent of nuclear pore 1/1315 25/18639 0.04 0.566965779467681 0.839635552172805 0.999999999999966 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 1/1315 25/18639 0.04 0.566965779467681 0.839635552172805 0.999999999999966 GO:0004180 carboxypeptidase activity 2/1315 46/18639 0.0434782608695652 0.616267151595305 0.845178831984178 0.999999999999966 GO:0005201 extracellular matrix structural constituent 9/1315 168/18639 0.0535714285714286 0.759329168929929 0.845856353871367 0.999999999999966 GO:0001664 G protein-coupled receptor binding 17/1315 297/18639 0.0572390572390572 0.811314667588432 0.846153100768955 0.999999999999966 GO:0038024 cargo receptor activity 3/1315 65/18639 0.0461538461538462 0.65419128400117 0.846316108784166 0.999999999999966 GO:0001637 G protein-coupled chemoattractant receptor activity 1/1315 26/18639 0.0384615384615385 0.545159403334308 0.850964618944738 0.999999999999966 GO:0004529 DNA exonuclease activity 1/1315 26/18639 0.0384615384615385 0.545159403334308 0.850964618944738 0.999999999999966 GO:0004950 chemokine receptor activity 1/1315 26/18639 0.0384615384615385 0.545159403334308 0.850964618944738 0.999999999999966 GO:0008157 protein phosphatase 1 binding 1/1315 26/18639 0.0384615384615385 0.545159403334308 0.850964618944738 0.999999999999966 GO:0019865 immunoglobulin binding 1/1315 26/18639 0.0384615384615385 0.545159403334308 0.850964618944738 0.999999999999966 GO:0030507 spectrin binding 1/1315 26/18639 0.0384615384615385 0.545159403334308 0.850964618944738 0.999999999999966 GO:0070412 R-SMAD binding 1/1315 26/18639 0.0384615384615385 0.545159403334308 0.850964618944738 0.999999999999966 GO:0140789 histone phosphatase activity 7/1315 136/18639 0.0514705882352941 0.729551554462089 0.852724541915638 0.999999999999966 GO:0008235 metalloexopeptidase activity 3/1315 66/18639 0.0454545454545455 0.644279294849637 0.853590744130729 0.999999999999966 GO:0061749 forked DNA-dependent helicase activity 2/1315 47/18639 0.0425531914893617 0.603155084540086 0.853689297287086 0.999999999999966 GO:0099095 ligand-gated monoatomic anion channel activity 2/1315 47/18639 0.0425531914893617 0.603155084540086 0.853689297287086 0.999999999999966 GO:1990518 single-stranded 3'-5' DNA helicase activity 2/1315 47/18639 0.0425531914893617 0.603155084540086 0.853689297287086 0.999999999999966 GO:0051020 GTPase binding 18/1315 315/18639 0.0571428571428571 0.809951113525258 0.853841349855192 0.999999999999966 GO:0001671 ATPase activator activity 1/1315 27/18639 0.037037037037037 0.524968314321926 0.861493900956648 0.999999999999966 GO:0004683 calcium/calmodulin-dependent protein kinase activity 1/1315 27/18639 0.037037037037037 0.524968314321926 0.861493900956648 0.999999999999966 GO:0005044 scavenger receptor activity 1/1315 27/18639 0.037037037037037 0.524968314321926 0.861493900956648 0.999999999999966 GO:0008266 poly(U) RNA binding 1/1315 27/18639 0.037037037037037 0.524968314321926 0.861493900956648 0.999999999999966 GO:0015252 proton channel activity 1/1315 27/18639 0.037037037037037 0.524968314321926 0.861493900956648 0.999999999999966 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 1/1315 27/18639 0.037037037037037 0.524968314321926 0.861493900956648 0.999999999999966 GO:0046943 carboxylic acid transmembrane transporter activity 10/1315 188/18639 0.0531914893617021 0.753943855675107 0.86156560210581 0.999999999999966 GO:0009378 four-way junction helicase activity 2/1315 48/18639 0.0416666666666667 0.590589353612167 0.861770682815856 0.999999999999966 GO:0032266 phosphatidylinositol-3-phosphate binding 2/1315 48/18639 0.0416666666666667 0.590589353612167 0.861770682815856 0.999999999999966 GO:0036121 double-stranded DNA helicase activity 2/1315 48/18639 0.0416666666666667 0.590589353612167 0.861770682815856 0.999999999999966 GO:0038187 pattern recognition receptor activity 2/1315 48/18639 0.0416666666666667 0.590589353612167 0.861770682815856 0.999999999999966 GO:0043138 3'-5' DNA helicase activity 2/1315 48/18639 0.0416666666666667 0.590589353612167 0.861770682815856 0.999999999999966 GO:0140693 molecular condensate scaffold activity 2/1315 48/18639 0.0416666666666667 0.590589353612167 0.861770682815856 0.999999999999966 GO:0005342 organic acid transmembrane transporter activity 10/1315 189/18639 0.0529100529100529 0.749954734745609 0.865737429418161 0.999999999999966 GO:0030145 manganese ion binding 3/1315 68/18639 0.0441176470588235 0.625329903824648 0.867241636218376 0.999999999999966 GO:0140223 general transcription initiation factor activity 3/1315 68/18639 0.0441176470588235 0.625329903824648 0.867241636218376 0.999999999999966 GO:0005096 GTPase activator activity 15/1315 271/18639 0.0553505535055351 0.784546742805831 0.867326175887908 0.999999999999966 GO:0140030 modification-dependent protein binding 9/1315 173/18639 0.0520231213872832 0.73738323919207 0.868424827932374 0.999999999999966 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 6/1315 122/18639 0.0491803278688525 0.697089073116001 0.868483625047535 0.999999999999966 GO:0035254 glutamate receptor binding 2/1315 49/18639 0.0408163265306122 0.578536509660899 0.869441116576383 0.999999999999966 GO:0060590 ATPase regulator activity 2/1315 49/18639 0.0408163265306122 0.578536509660899 0.869441116576383 0.999999999999966 GO:0019902 phosphatase binding 10/1315 190/18639 0.0526315789473684 0.746007604562738 0.869808013604273 0.999999999999966 GO:0005242 inward rectifier potassium channel activity 1/1315 28/18639 0.0357142857142857 0.506219445953286 0.87127981973174 0.999999999999966 GO:0050698 proteoglycan sulfotransferase activity 1/1315 28/18639 0.0357142857142857 0.506219445953286 0.87127981973174 0.999999999999966 GO:0051019 mitogen-activated protein kinase binding 1/1315 28/18639 0.0357142857142857 0.506219445953286 0.87127981973174 0.999999999999966 GO:0005006 epidermal growth factor receptor activity 2/1315 50/18639 0.04 0.566965779467681 0.876718306508191 0.999999999999966 GO:0008028 monocarboxylic acid transmembrane transporter activity 3/1315 70/18639 0.0428571428571429 0.607463335143943 0.879757441402003 0.999999999999966 GO:0003785 actin monomer binding 1/1315 29/18639 0.0344827586206897 0.48876360298938 0.880374819304721 0.999999999999966 GO:0004181 metallocarboxypeptidase activity 1/1315 29/18639 0.0344827586206897 0.48876360298938 0.880374819304721 0.999999999999966 GO:0106222 lncRNA binding 1/1315 29/18639 0.0344827586206897 0.48876360298938 0.880374819304721 0.999999999999966 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 4/1315 89/18639 0.0449438202247191 0.637040201649079 0.881713343898523 0.999999999999966 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 4/1315 89/18639 0.0449438202247191 0.637040201649079 0.881713343898523 0.999999999999966 GO:0016597 amino acid binding 2/1315 51/18639 0.0392156862745098 0.555848803399687 0.88361950950524 0.999999999999966 GO:0008236 serine-type peptidase activity 10/1315 194/18639 0.0515463917525773 0.730626004468661 0.88510625678618 0.999999999999966 GO:0140299 molecular sensor activity 3/1315 71/18639 0.0422535211267606 0.598907513522198 0.885612978291257 0.999999999999966 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 28/1315 484/18639 0.0578512396694215 0.819991829808629 0.886478958579167 0.999999999999966 GO:0140793 histone H2AXY142 phosphatase activity 4/1315 90/18639 0.0444444444444444 0.629961977186312 0.886917592205403 0.999999999999966 GO:0008187 poly-pyrimidine tract binding 1/1315 30/18639 0.0333333333333333 0.472471482889734 0.888827646419944 0.999999999999966 GO:0031624 ubiquitin conjugating enzyme binding 1/1315 30/18639 0.0333333333333333 0.472471482889734 0.888827646419944 0.999999999999966 GO:0098918 structural constituent of synapse 1/1315 30/18639 0.0333333333333333 0.472471482889734 0.888827646419944 0.999999999999966 GO:0004620 phospholipase activity 5/1315 109/18639 0.0458715596330275 0.650190114068441 0.890716983229136 0.999999999999966 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 4/1315 91/18639 0.043956043956044 0.623039318096352 0.891920789644098 0.999999999999966 GO:0004222 metalloendopeptidase activity 5/1315 110/18639 0.0454545454545455 0.644279294849637 0.895194422265976 0.999999999999966 GO:0005544 calcium-dependent phospholipid binding 2/1315 53/18639 0.0377358490566038 0.534873376856302 0.896360585593554 0.999999999999966 GO:0008146 sulfotransferase activity 2/1315 53/18639 0.0377358490566038 0.534873376856302 0.896360585593554 0.999999999999966 GO:0016251 RNA polymerase II general transcription initiation factor activity 2/1315 53/18639 0.0377358490566038 0.534873376856302 0.896360585593554 0.999999999999966 GO:0005184 neuropeptide hormone activity 1/1315 31/18639 0.032258064516129 0.457230467312646 0.896683611004703 0.999999999999966 GO:0017147 Wnt-protein binding 1/1315 31/18639 0.032258064516129 0.457230467312646 0.896683611004703 0.999999999999966 GO:0017171 serine hydrolase activity 10/1315 198/18639 0.0505050505050505 0.715865883166263 0.898900893450622 0.999999999999966 GO:0016741 transferase activity, transferring one-carbon groups 11/1315 215/18639 0.0511627906976744 0.725188787691219 0.899356580986424 0.999999999999966 GO:0042578 phosphoric ester hydrolase activity 20/1315 363/18639 0.0550964187327824 0.780944599817742 0.900681052536992 0.999999999999966 GO:0035064 methylated histone binding 3/1315 74/18639 0.0405405405405405 0.574627479190217 0.901679424419125 0.999999999999966 GO:0001216 DNA-binding transcription activator activity 28/1315 491/18639 0.0570264765784114 0.808301518589361 0.902029761558184 0.999999999999966 GO:0140463 chromatin-protein adaptor activity 2/1315 54/18639 0.037037037037037 0.524968314321926 0.902232524336322 0.999999999999966 GO:0016298 lipase activity 6/1315 130/18639 0.0461538461538462 0.65419128400117 0.903530587024506 0.999999999999966 GO:0016798 hydrolase activity, acting on glycosyl bonds 6/1315 130/18639 0.0461538461538462 0.65419128400117 0.903530587024506 0.999999999999966 GO:0047498 calcium-dependent phospholipase A2 activity 1/1315 32/18639 0.03125 0.442942015209125 0.903984828305262 0.999999999999966 GO:0160041 neuropeptide activity 1/1315 32/18639 0.03125 0.442942015209125 0.903984828305262 0.999999999999966 GO:0003725 double-stranded RNA binding 3/1315 75/18639 0.04 0.566965779467681 0.906564412603841 0.999999999999966 GO:0098632 cell-cell adhesion mediator activity 2/1315 55/18639 0.0363636363636364 0.51542343587971 0.907792584236641 0.999999999999966 GO:0004867 serine-type endopeptidase inhibitor activity 4/1315 95/18639 0.0421052631578947 0.59680608365019 0.910040826638129 0.999999999999966 GO:0019239 deaminase activity 1/1315 33/18639 0.0303030303030303 0.429519529899758 0.910770443975632 0.999999999999966 GO:0019956 chemokine binding 1/1315 33/18639 0.0303030303030303 0.429519529899758 0.910770443975632 0.999999999999966 GO:0030296 protein tyrosine kinase activator activity 1/1315 33/18639 0.0303030303030303 0.429519529899758 0.910770443975632 0.999999999999966 GO:0071889 14-3-3 protein binding 1/1315 33/18639 0.0303030303030303 0.429519529899758 0.910770443975632 0.999999999999966 GO:0140034 methylation-dependent protein binding 3/1315 76/18639 0.0394736842105263 0.559505703422053 0.911228533624792 0.999999999999966 GO:0170055 lipid transmembrane transporter activity 2/1315 56/18639 0.0357142857142857 0.506219445953286 0.913055503254607 0.999999999999966 GO:0035401 histone H3Y41 kinase activity 5/1315 115/18639 0.0434782608695652 0.616267151595305 0.915273173523615 0.999999999999966 GO:0140801 histone H2AXY142 kinase activity 5/1315 115/18639 0.0434782608695652 0.616267151595305 0.915273173523615 0.999999999999966 GO:0003724 RNA helicase activity 3/1315 77/18639 0.038961038961039 0.552239395585403 0.915680150639505 0.999999999999966 GO:0008168 methyltransferase activity 10/1315 204/18639 0.0490196078431373 0.694811004249609 0.916989057999821 0.999999999999966 GO:0008175 tRNA methyltransferase activity 1/1315 34/18639 0.0294117647058824 0.416886602549765 0.917076843318427 0.999999999999966 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 1/1315 34/18639 0.0294117647058824 0.416886602549765 0.917076843318427 0.999999999999966 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 1/1315 34/18639 0.0294117647058824 0.416886602549765 0.917076843318427 0.999999999999966 GO:0019825 oxygen binding 1/1315 34/18639 0.0294117647058824 0.416886602549765 0.917076843318427 0.999999999999966 GO:0052866 phosphatidylinositol phosphate phosphatase activity 1/1315 34/18639 0.0294117647058824 0.416886602549765 0.917076843318427 0.999999999999966 GO:0004725 protein tyrosine phosphatase activity 4/1315 98/18639 0.0408163265306122 0.578536509660899 0.92180443967119 0.999999999999966 GO:0017116 single-stranded DNA helicase activity 2/1315 58/18639 0.0344827586206897 0.48876360298938 0.922746244447173 0.999999999999966 GO:0043015 gamma-tubulin binding 1/1315 35/18639 0.0285714285714286 0.404975556762629 0.92293784579283 0.999999999999966 GO:0008186 ATP-dependent activity, acting on RNA 3/1315 79/18639 0.0379746835443038 0.538258651393368 0.923978371247911 0.999999999999966 GO:0015370 solute:sodium symporter activity 3/1315 79/18639 0.0379746835443038 0.538258651393368 0.923978371247911 0.999999999999966 GO:0005126 cytokine receptor binding 14/1315 275/18639 0.0509090909090909 0.721592810231593 0.924962296328499 0.999999999999966 GO:0045505 dynein intermediate chain binding 1/1315 36/18639 0.0277777777777778 0.393726235741445 0.928384885826287 0.999999999999966 GO:0004714 transmembrane receptor protein tyrosine kinase activity 2/1315 60/18639 0.0333333333333333 0.472471482889734 0.931412174719321 0.999999999999966 GO:0030971 receptor tyrosine kinase binding 3/1315 81/18639 0.037037037037037 0.524968314321926 0.931522073323543 0.999999999999966 GO:0140767 enzyme-substrate adaptor activity 6/1315 139/18639 0.0431654676258993 0.611833574965123 0.93305198752176 0.999999999999966 GO:0003730 mRNA 3'-UTR binding 13/1315 262/18639 0.049618320610687 0.703297245522886 0.93331060869673 0.999999999999966 GO:0030280 structural constituent of skin epidermis 1/1315 37/18639 0.027027027027027 0.383084986126811 0.933447180893665 0.999999999999966 GO:0015026 coreceptor activity 2/1315 61/18639 0.0327868852459016 0.464726048744001 0.935392146846784 0.999999999999966 GO:0004713 protein tyrosine kinase activity 6/1315 140/18639 0.0428571428571429 0.607463335143943 0.93578036296424 0.999999999999966 GO:0042887 amide transmembrane transporter activity 1/1315 38/18639 0.0263157894736842 0.373003802281369 0.938151887759853 0.999999999999966 GO:0030165 PDZ domain binding 3/1315 83/18639 0.036144578313253 0.512318475422603 0.938370957558855 0.999999999999966 GO:0000217 DNA secondary structure binding 1/1315 39/18639 0.0256410256410256 0.363439602222872 0.942524247718769 0.999999999999966 GO:0046982 protein heterodimerization activity 19/1315 369/18639 0.0514905149051491 0.729833997959751 0.944542214947374 0.999999999999966 GO:0071949 FAD binding 1/1315 40/18639 0.025 0.3543536121673 0.946587721603168 0.999999999999966 GO:0004497 monooxygenase activity 4/1315 106/18639 0.0377358490566038 0.534873376856302 0.946708600254645 0.999999999999966 GO:0008013 beta-catenin binding 4/1315 106/18639 0.0377358490566038 0.534873376856302 0.946708600254645 0.999999999999966 GO:0015081 sodium ion transmembrane transporter activity 7/1315 164/18639 0.0426829268292683 0.604993971992952 0.948897014105815 0.999999999999966 GO:0008081 phosphoric diester hydrolase activity 3/1315 87/18639 0.0344827586206897 0.48876360298938 0.950206101776161 0.999999999999966 GO:0004812 aminoacyl-tRNA ligase activity 1/1315 41/18639 0.024390243902439 0.34571084113883 0.950364115285185 0.999999999999966 GO:0016875 ligase activity, forming carbon-oxygen bonds 1/1315 41/18639 0.024390243902439 0.34571084113883 0.950364115285185 0.999999999999966 GO:0031490 chromatin DNA binding 5/1315 128/18639 0.0390625 0.553677519011407 0.952472366054485 0.999999999999966 GO:0035198 miRNA binding 1/1315 42/18639 0.0238095238095238 0.337479630635524 0.95387369633691 0.999999999999966 GO:1901981 phosphatidylinositol phosphate binding 8/1315 185/18639 0.0432432432432432 0.612935977802898 0.954048094671847 0.999999999999966 GO:0035591 signaling adaptor activity 5/1315 129/18639 0.0387596899224806 0.549385445220621 0.954602671356883 0.999999999999966 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 7/1315 167/18639 0.0419161676646707 0.59412581680745 0.954779422868973 0.999999999999966 GO:0008173 RNA methyltransferase activity 2/1315 67/18639 0.0298507462686567 0.423108790647523 0.955033354440619 0.999999999999966 GO:0001223 transcription coactivator binding 1/1315 44/18639 0.0227272727272727 0.322139647424819 0.96016644235533 0.999999999999966 GO:0043014 alpha-tubulin binding 1/1315 44/18639 0.0227272727272727 0.322139647424819 0.96016644235533 0.999999999999966 GO:0008080 N-acetyltransferase activity 2/1315 69/18639 0.0289855072463768 0.410844767730203 0.960202872647419 0.999999999999966 GO:0005516 calmodulin binding 9/1315 207/18639 0.0434782608695652 0.616267151595305 0.960312734225315 0.999999999999966 GO:0016278 lysine N-methyltransferase activity 2/1315 70/18639 0.0285714285714286 0.404975556762629 0.962568914742872 0.999999999999966 GO:0004715 non-membrane spanning protein tyrosine kinase activity 1/1315 45/18639 0.0222222222222222 0.314980988593156 0.962983389292826 0.999999999999966 GO:0008009 chemokine activity 1/1315 45/18639 0.0222222222222222 0.314980988593156 0.962983389292826 0.999999999999966 GO:0042605 peptide antigen binding 1/1315 45/18639 0.0222222222222222 0.314980988593156 0.962983389292826 0.999999999999966 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 1/1315 46/18639 0.0217391304347826 0.308133575797652 0.96560126834413 0.999999999999966 GO:0042379 chemokine receptor binding 2/1315 72/18639 0.0277777777777778 0.393726235741445 0.966902007908989 0.999999999999966 GO:0035091 phosphatidylinositol binding 13/1315 284/18639 0.0457746478873239 0.648816472982381 0.967490323924559 0.999999999999966 GO:0008276 protein methyltransferase activity 3/1315 95/18639 0.0315789473684211 0.447604562737643 0.967789445886962 0.999999999999966 GO:0140938 histone H3 methyltransferase activity 1/1315 47/18639 0.0212765957446809 0.301577542270043 0.968034137280152 0.999999999999966 GO:1990782 protein tyrosine kinase binding 4/1315 117/18639 0.0341880341880342 0.484586136297163 0.96918891764758 0.999999999999966 GO:0004896 cytokine receptor activity 3/1315 96/18639 0.03125 0.442942015209125 0.969520506114939 0.999999999999966 GO:0003678 DNA helicase activity 2/1315 74/18639 0.027027027027027 0.383084986126811 0.970750106558693 0.999999999999966 GO:0005125 cytokine activity 10/1315 234/18639 0.0427350427350427 0.605732670371454 0.97158888834398 0.999999999999966 GO:0005004 GPI-linked ephrin receptor activity 1/1315 49/18639 0.0204081632653061 0.289268254830449 0.972396185702948 0.999999999999966 GO:0005008 hepatocyte growth factor receptor activity 1/1315 49/18639 0.0204081632653061 0.289268254830449 0.972396185702948 0.999999999999966 GO:0005009 insulin receptor activity 1/1315 49/18639 0.0204081632653061 0.289268254830449 0.972396185702948 0.999999999999966 GO:0005011 macrophage colony-stimulating factor receptor activity 1/1315 49/18639 0.0204081632653061 0.289268254830449 0.972396185702948 0.999999999999966 GO:0005018 platelet-derived growth factor alpha-receptor activity 1/1315 49/18639 0.0204081632653061 0.289268254830449 0.972396185702948 0.999999999999966 GO:0005020 stem cell factor receptor activity 1/1315 49/18639 0.0204081632653061 0.289268254830449 0.972396185702948 0.999999999999966 GO:0008288 boss receptor activity 1/1315 49/18639 0.0204081632653061 0.289268254830449 0.972396185702948 0.999999999999966 GO:0036332 placental growth factor receptor activity 1/1315 49/18639 0.0204081632653061 0.289268254830449 0.972396185702948 0.999999999999966 GO:0038062 protein tyrosine kinase collagen receptor activity 1/1315 49/18639 0.0204081632653061 0.289268254830449 0.972396185702948 0.999999999999966 GO:0060175 brain-derived neurotrophic factor receptor activity 1/1315 49/18639 0.0204081632653061 0.289268254830449 0.972396185702948 0.999999999999966 GO:0008170 N-methyltransferase activity 3/1315 98/18639 0.0306122448979592 0.433902382245674 0.972722012419548 0.999999999999966 GO:0005007 fibroblast growth factor receptor activity 1/1315 50/18639 0.02 0.28348288973384 0.974348795482433 0.999999999999966 GO:0005017 platelet-derived growth factor receptor activity 1/1315 50/18639 0.02 0.28348288973384 0.974348795482433 0.999999999999966 GO:0005019 platelet-derived growth factor beta-receptor activity 1/1315 50/18639 0.02 0.28348288973384 0.974348795482433 0.999999999999966 GO:0048020 CCR chemokine receptor binding 1/1315 50/18639 0.02 0.28348288973384 0.974348795482433 0.999999999999966 GO:0005010 insulin-like growth factor receptor activity 1/1315 51/18639 0.0196078431372549 0.277924401699843 0.976163381201977 0.999999999999966 GO:0005021 vascular endothelial growth factor receptor activity 1/1315 51/18639 0.0196078431372549 0.277924401699843 0.976163381201977 0.999999999999966 GO:0005030 neurotrophin receptor activity 1/1315 51/18639 0.0196078431372549 0.277924401699843 0.976163381201977 0.999999999999966 GO:0005272 sodium channel activity 1/1315 51/18639 0.0196078431372549 0.277924401699843 0.976163381201977 0.999999999999966 GO:0019199 transmembrane receptor protein kinase activity 2/1315 78/18639 0.0256410256410256 0.363439602222872 0.977192770760987 0.999999999999966 GO:0046332 SMAD binding 2/1315 79/18639 0.0253164556962025 0.358839100928912 0.978574962956132 0.999999999999966 GO:0005003 ephrin receptor activity 1/1315 53/18639 0.0188679245283019 0.267436688428151 0.979416790672 0.999999999999966 GO:0005005 transmembrane-ephrin receptor activity 1/1315 53/18639 0.0188679245283019 0.267436688428151 0.979416790672 0.999999999999966 GO:0017046 peptide hormone binding 1/1315 53/18639 0.0188679245283019 0.267436688428151 0.979416790672 0.999999999999966 GO:0034212 protein N-acetyltransferase activity 1/1315 53/18639 0.0188679245283019 0.267436688428151 0.979416790672 0.999999999999966 GO:0038064 collagen receptor activity 1/1315 53/18639 0.0188679245283019 0.267436688428151 0.979416790672 0.999999999999966 GO:0140597 protein carrier chaperone 7/1315 188/18639 0.0372340425531915 0.527760698972575 0.981557233825453 0.999999999999966 GO:0008374 O-acyltransferase activity 1/1315 55/18639 0.0181818181818182 0.257711717939855 0.98222644042376 0.999999999999966 GO:0000510 H3-H4 histone complex chaperone activity 5/1315 151/18639 0.033112582781457 0.469342532671921 0.984149227960147 0.999999999999966 GO:0140584 chromatin extrusion motor activity 5/1315 151/18639 0.033112582781457 0.469342532671921 0.984149227960147 0.999999999999966 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 5/1315 151/18639 0.033112582781457 0.469342532671921 0.984149227960147 0.999999999999966 GO:0140849 ATP-dependent H2AZ histone chaperone activity 5/1315 151/18639 0.033112582781457 0.469342532671921 0.984149227960147 0.999999999999966 GO:0004843 cysteine-type deubiquitinase activity 3/1315 108/18639 0.0277777777777778 0.393726235741445 0.984481871202111 0.999999999999966 GO:0015616 DNA translocase activity 5/1315 152/18639 0.0328947368421053 0.466254752851711 0.984916621165594 0.999999999999966 GO:0140674 ATP-dependent histone chaperone activity 5/1315 152/18639 0.0328947368421053 0.466254752851711 0.984916621165594 0.999999999999966 GO:0005244 voltage-gated monoatomic ion channel activity 6/1315 173/18639 0.0346820809248555 0.491588826128047 0.98525220670498 0.999999999999966 GO:0061775 cohesin loader activity 5/1315 153/18639 0.0326797385620915 0.463207336166406 0.985648907107095 0.999999999999966 GO:0061980 regulatory RNA binding 1/1315 58/18639 0.0172413793103448 0.24438180149469 0.985738899075974 0.999999999999966 GO:0022832 voltage-gated channel activity 6/1315 175/18639 0.0342857142857143 0.485970668115155 0.986583150914684 0.999999999999966 GO:0045309 protein phosphorylated amino acid binding 1/1315 59/18639 0.0169491525423729 0.240239737062577 0.986748174557115 0.999999999999966 GO:0016887 ATP hydrolysis activity 19/1315 417/18639 0.0455635491606715 0.645824329129852 0.986951996190077 0.999999999999966 GO:0004386 helicase activity 5/1315 155/18639 0.032258064516129 0.457230467312646 0.987014021923921 0.999999999999966 GO:0099094 ligand-gated monoatomic cation channel activity 4/1315 136/18639 0.0294117647058824 0.416886602549765 0.988592001846229 0.999999999999966 GO:0140658 ATP-dependent chromatin remodeler activity 5/1315 158/18639 0.0316455696202532 0.44854887616114 0.988833644467273 0.999999999999966 GO:0017124 SH3 domain binding 3/1315 115/18639 0.0260869565217391 0.369760290957183 0.989630107042145 0.999999999999966 GO:0003689 DNA clamp loader activity 5/1315 160/18639 0.03125 0.442942015209125 0.989909528501101 0.999999999999966 GO:0051219 phosphoprotein binding 2/1315 93/18639 0.021505376344086 0.304820311541764 0.991175137381085 0.999999999999966 GO:0031267 small GTPase binding 11/1315 283/18639 0.03886925795053 0.550938478281315 0.991371816546956 0.999999999999966 GO:0016410 N-acyltransferase activity 2/1315 94/18639 0.0212765957446809 0.301577542270043 0.991723166339824 0.999999999999966 GO:0140713 histone chaperone activity 5/1315 164/18639 0.0304878048780488 0.432138551423537 0.991773137044379 0.999999999999966 GO:0046873 metal ion transmembrane transporter activity 20/1315 450/18639 0.0444444444444444 0.629961977186312 0.992128808198027 0.999999999999966 GO:0016500 protein-hormone receptor activity 1/1315 67/18639 0.0149253731343284 0.211554395323761 0.99263465951934 0.999999999999966 GO:0042054 histone methyltransferase activity 1/1315 67/18639 0.0149253731343284 0.211554395323761 0.99263465951934 0.999999999999966 GO:0008528 G protein-coupled peptide receptor activity 3/1315 122/18639 0.0245901639344262 0.348544536558 0.993111959600887 0.999999999999966 GO:0003777 microtubule motor activity 1/1315 68/18639 0.0147058823529412 0.208443301274883 0.993156166235475 0.999999999999966 GO:0030594 neurotransmitter receptor activity 2/1315 97/18639 0.0206185567010309 0.292250401787464 0.993175068846211 0.999999999999966 GO:0002039 p53 binding 1/1315 69/18639 0.0144927536231884 0.205422383865102 0.993640773494123 0.999999999999966 GO:0016279 protein-lysine N-methyltransferase activity 1/1315 69/18639 0.0144927536231884 0.205422383865102 0.993640773494123 0.999999999999966 GO:0015631 tubulin binding 16/1315 385/18639 0.0415584415584416 0.589055355291097 0.993852121723806 0.999999999999966 GO:0008017 microtubule binding 10/1315 276/18639 0.036231884057971 0.513555959662754 0.99483643927125 0.999999999999966 GO:0001653 peptide receptor activity 3/1315 128/18639 0.0234375 0.332206511406844 0.995170428240247 0.999999999999966 GO:0005216 monoatomic ion channel activity 19/1315 448/18639 0.0424107142857143 0.601135592069527 0.995441800437552 0.999999999999966 GO:0140375 immune receptor activity 4/1315 156/18639 0.0256410256410256 0.363439602222872 0.996194931003314 0.999999999999966 GO:0015276 ligand-gated monoatomic ion channel activity 5/1315 186/18639 0.0268817204301075 0.381025389427205 0.997412996686509 0.999999999999966 GO:0022834 ligand-gated channel activity 5/1315 188/18639 0.0265957446808511 0.376971927837554 0.997677298245144 0.999999999999966 GO:0022843 voltage-gated monoatomic cation channel activity 3/1315 143/18639 0.020979020979021 0.297359674545986 0.998042539730376 0.999999999999966 GO:0005261 monoatomic cation channel activity 12/1315 341/18639 0.0351906158357771 0.498796873431977 0.998283398656968 0.999999999999966 GO:0005267 potassium channel activity 2/1315 124/18639 0.0161290322580645 0.228615233656323 0.998833812049185 0.999999999999966 GO:0004674 protein serine/threonine kinase activity 16/1315 433/18639 0.0369515011547344 0.523755916367372 0.999040292284563 0.999999999999966 GO:0140097 catalytic activity, acting on DNA 11/1315 336/18639 0.0327380952380952 0.464034492123846 0.999121408572543 0.999999999999966 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 6/1315 229/18639 0.0262008733624454 0.371374964716821 0.999126655000085 0.999999999999966 GO:0005249 voltage-gated potassium channel activity 1/1315 98/18639 0.0102040816326531 0.144634127415225 0.999245483670056 0.999999999999966 GO:0008094 ATP-dependent activity, acting on DNA 5/1315 210/18639 0.0238095238095238 0.337479630635524 0.999307568537474 0.999999999999966 GO:0015079 potassium ion transmembrane transporter activity 3/1315 160/18639 0.01875 0.265765209125475 0.999312612908412 0.999999999999966 GO:0022836 gated channel activity 9/1315 318/18639 0.0283018867924528 0.401155032642227 0.999723084003049 0.999999999999966 GO:0106310 protein serine kinase activity 11/1315 361/18639 0.0304709141274238 0.43189913948369 0.999725362180266 0.999999999999966 GO:0016755 aminoacyltransferase activity 16/1315 496/18639 0.032258064516129 0.457230467312646 0.999935557210133 0.999999999999966 GO:0045182 translation regulator activity 9/1315 356/18639 0.0252808988764045 0.358335113427607 0.999960590570484 0.999999999999966 GO:0019787 ubiquitin-like protein transferase activity 14/1315 479/18639 0.0292275574112735 0.414275621740476 0.999979550017169 0.999999999999966 GO:0035402 histone H3T11 kinase activity 4/1315 247/18639 0.0161943319838057 0.229540801403919 0.999983354062235 0.999999999999966 GO:0061630 ubiquitin protein ligase activity 8/1315 353/18639 0.0226628895184136 0.321227070519932 0.99998682068049 0.999999999999966 GO:0141003 histone H2AX kinase activity 8/1315 354/18639 0.0225988700564972 0.320319649416769 0.999987528029195 0.999999999999966 GO:0140996 histone H3 kinase activity 8/1315 357/18639 0.0224089635854342 0.317627887656964 0.99998943382633 0.999999999999966 GO:0035173 histone kinase activity 8/1315 360/18639 0.0222222222222222 0.314980988593156 0.99999105279535 0.999999999999966 GO:0061659 ubiquitin-like protein ligase activity 8/1315 372/18639 0.021505376344086 0.304820311541764 0.999995421790843 0.999999999999966 GO:0004842 ubiquitin-protein transferase activity 11/1315 449/18639 0.0244988864142539 0.347250755798691 0.99999671934784 0.999999999999966 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 3/1315 243/18639 0.0123456790123457 0.174989438107309 0.999996736265245 0.999999999999966 GO:0004676 3-phosphoinositide-dependent protein kinase activity 3/1315 245/18639 0.0122448979591837 0.17356095289827 0.999997141467467 0.999999999999966 GO:0004711 ribosomal protein S6 kinase activity 3/1315 245/18639 0.0122448979591837 0.17356095289827 0.999997141467467 0.999999999999966 GO:0035175 histone H3S10 kinase activity 3/1315 245/18639 0.0122448979591837 0.17356095289827 0.999997141467467 0.999999999999966 GO:0035979 histone H2AXS139 kinase activity 3/1315 245/18639 0.0122448979591837 0.17356095289827 0.999997141467467 0.999999999999966 GO:0044022 histone H3S28 kinase activity 3/1315 245/18639 0.0122448979591837 0.17356095289827 0.999997141467467 0.999999999999966 GO:0044023 histone H4S1 kinase activity 3/1315 245/18639 0.0122448979591837 0.17356095289827 0.999997141467467 0.999999999999966 GO:0044024 histone H2AS1 kinase activity 3/1315 245/18639 0.0122448979591837 0.17356095289827 0.999997141467467 0.999999999999966 GO:0044025 histone H2BS14 kinase activity 3/1315 245/18639 0.0122448979591837 0.17356095289827 0.999997141467467 0.999999999999966 GO:0072354 histone H3T3 kinase activity 3/1315 245/18639 0.0122448979591837 0.17356095289827 0.999997141467467 0.999999999999966 GO:0072371 histone H2AS121 kinase activity 3/1315 245/18639 0.0122448979591837 0.17356095289827 0.999997141467467 0.999999999999966 GO:0072518 Rho-dependent protein serine/threonine kinase activity 3/1315 245/18639 0.0122448979591837 0.17356095289827 0.999997141467467 0.999999999999966 GO:0140823 histone H2BS36 kinase activity 3/1315 245/18639 0.0122448979591837 0.17356095289827 0.999997141467467 0.999999999999966 GO:0140855 histone H3S57 kinase activity 3/1315 245/18639 0.0122448979591837 0.17356095289827 0.999997141467467 0.999999999999966 GO:0140995 histone H2A kinase activity 3/1315 245/18639 0.0122448979591837 0.17356095289827 0.999997141467467 0.999999999999966 GO:0140997 histone H4 kinase activity 3/1315 245/18639 0.0122448979591837 0.17356095289827 0.999997141467467 0.999999999999966 GO:0140998 histone H2B kinase activity 3/1315 245/18639 0.0122448979591837 0.17356095289827 0.999997141467467 0.999999999999966 GO:1990244 histone H2AT120 kinase activity 3/1315 245/18639 0.0122448979591837 0.17356095289827 0.999997141467467 0.999999999999966 GO:0003823 antigen binding 1/1315 174/18639 0.00574712643678161 0.08146060049823 0.999997217365889 0.999999999999966 GO:0004677 DNA-dependent protein kinase activity 3/1315 246/18639 0.0121951219512195 0.172855420569415 0.999997324930609 0.999999999999966 GO:0140857 histone H3T45 kinase activity 3/1315 246/18639 0.0121951219512195 0.172855420569415 0.999997324930609 0.999999999999966 GO:0035403 histone H3T6 kinase activity 3/1315 247/18639 0.0121457489878543 0.172155601052939 0.999997496703581 0.999999999999966 GO:0004679 AMP-activated protein kinase activity 3/1315 248/18639 0.0120967741935484 0.171461425242242 0.999997657525265 0.999999999999966 GO:0030371 translation repressor activity 5/1315 329/18639 0.0151975683890578 0.215412530192888 0.999999432364931 0.999999999999966 GO:0004984 olfactory receptor activity 1/1315 419/18639 0.00238663484486874 0.0338285071281432 0.999999999999966 0.999999999999966