category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	66/933	238/9376	2.78678159366641	C3/CFD/C1S/C1R/FOS/JUN/C2/RPL29/STAT3/RPL39/MASP1/NFKBIA/RPL36A/TNFRSF1A/IL6ST/RPS7/RPL12/RPS3A/RPS18/RPS6/MAPK10/PIK3R1/RPL22L1/TLR4/MAPK3/RPL13/RPS15/MYD88/RPL9/RPL7/RPS24/RPL26/RPS19/NFKBIB/RPL34/RPS15A/IL1B/IFNAR1/STAT2/RPS9/CXCL8/RPL8/RPS3/RPL35/RPS2/CCL2/IL6/CASP1/RPSA/MX2/IL6R/IFNAR2/RPL17/PIK3CA/RPS5/TLR3/RPL18A/CFB/PIK3CD/IRAK4/RPS12/RPS10/RPS27A/TRAF6/OAS2/PIK3CB	9.28137750147703
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	68/933	300/9376	2.27784208645945	INSR/HSPA1B/FOS/HSPA1A/JUN/JUND/HGF/DUSP1/NR4A1/FGF7/GADD45A/MAP3K8/RASGRP2/RPS6KA2/HSPB1/MYC/MAP3K5/TNFRSF1A/FGF10/VEGFC/NTF3/MAPK10/MAPKAPK2/RRAS/MAPK3/TGFBR2/MYD88/CACNA1C/NTRK1/SRF/IL1B/GADD45B/MAP4K4/MRAS/MAP3K20/IGF1R/MAP3K4/DUSP8/ECSIT/NFKB2/RPS6KA4/CDC25B/KITLG/FGF2/MAP3K6/CACNA1B/GNG12/PLA2G4C/FLT3LG/PPP3R1/PPP3CA/TGFB2/MAP3K10/NGF/CACNB2/DUSP3/IL1RAP/GADD45G/HSPA8/MEF2C/IRAK4/DUSP16/BDNF/CSF1/DUSP5/NGFR/TRAF6/NRTN	7.47771032009178
NA	NA	hsa04517	IgSF CAM signaling	61/933	299/9376	2.05019231665394	ACTB/FOXO1/ACTG1/TUBB2B/PTPRF/NLGN4X/APP/NLGN1/PMP22/NCAM2/MAPK10/LRFN4/ACTR3B/PIK3R1/ROBO2/FYN/MAPK3/SORBS1/TJP2/ANK2/LYN/LRRC4C/PTPN11/SLIT3/PTPRD/MAGI1/MYLK3/ITGA5/MYL9/KIRREL1/PRKCI/TUBB2A/NRCAM/TUBA1A/CADM1/VCL/ROBO1/PPFIA2/TUBB3/PXN/TUBB4A/PAK3/NCK2/PLXNA4/EPB41L3/CD226/VAV3/EPB41L2/PIK3CA/IL1RAP/CNTNAP1/NCAM1/CLEC4M/ROBO3/ICAM1/PVR/PIK3CD/TRAF6/KCNA4/PIK3CB/CADM2	6.13495425082124
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	35/933	133/9376	2.64455350595137	INSR/FBXO32/SOD2/IRS2/STAT3/GADD45A/FOXO1/PRKAA2/BCL6/HOMER1/MAPK10/PIK3R1/MAPK3/GABARAPL1/TGFBR2/KLF2/SETD7/CSNK1E/GADD45B/CCNG2/IGF1R/PLK3/IL6/FOXO3/TGFB2/EP300/SGK3/PIK3CA/GADD45G/SMAD3/CDKN2B/PIK3CD/SIRT1/PCK2/PIK3CB	6.34958611098606
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	43/933	184/9376	2.34847849387204	CXCL12/TRPC4/EPHA7/EPHA5/BOC/SEMA3E/EPHB1/PIK3R1/ROBO2/FYN/RRAS/MAPK3/LIMK2/LRRC4C/PTPN11/SLIT3/DPYSL2/MYL9/CFL2/PLXNC1/SEMA4B/WNT5B/EPHB6/ROBO1/SEMA3C/NTNG1/CAMK2D/PPP3R1/PPP3CA/PAK3/NCK2/PLXNA4/PIK3CA/SEMA6D/BMPR2/ROBO3/SEMA4A/EPHA3/PIK3CD/FZD3/WNT5A/SEMA4F/PIK3CB	6.14081471338849
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	29/933	103/9376	2.8294154986004	C3/FOS/JUN/SERPINE1/NFKBIA/ADCY1/TNFRSF1A/IFNGR2/MAPK10/GNAQ/PIK3R1/TLR4/MAPK3/TGFBR2/MYD88/GNA14/IL1B/IFNGR1/GNAL/CXCL8/CCL2/IL6/PLCB3/TGFB2/PIK3CA/PIK3CD/IRAK4/TRAF6/PIK3CB	6.20581610255603
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	45/933	204/9376	2.216758085871	HGF/ACTB/STAT3/ACTG1/DCN/HIF1A/TIMP3/MYC/MMP2/CD44/HSPG2/TWIST1/CAV2/TWIST2/RPS6/PIK3R1/TLR4/RRAS/MAPK3/CAV1/ANK2/PTPN11/WNT2/SDC2/ITGA5/FN1/MRAS/IGF1R/WNT5B/ANK1/THBS1/FGF2/HCLS1/CAMK2D/PXN/TGFB2/VAV3/PIK3CA/PPP1R12B/PIK3CD/FZD3/GAB1/WNT5A/PIK3CB/VTN	5.84070628428207
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	28/933	101/9376	2.7859454755765	PIM1/EGR1/JUN/STAT3/SERPINE1/FOXO1/VCAM1/MMP2/VEGFC/MAPK10/PIK3R1/MAPK3/TGFBR2/IL1B/FN1/CXCL8/CCL2/IL6/PLCD1/PLCB3/TGFB2/COL4A4/PIK3CA/ICAM1/SMAD3/PIK3CD/STAT5A/PIK3CB	5.9986011860344
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	46/933	216/9376	2.14012941129769	SOD2/HSPA1B/FOS/HSPA1A/JUN/HSP90AA1/STAT3/LDLR/NFKBIA/MAP3K5/TNFRSF1A/VCAM1/CXCL2/NFE2L2/MAPK10/PIK3R1/TLR4/ERO1A/MAPK3/MYD88/HSPD1/LYN/TANK/HSPA2/IL1B/CASP7/XBP1/CXCL8/CCL2/IL6/POU2F3/CASP1/CD40/CAMK2D/PPP3R1/PPP3CA/PLCB3/VAV3/PIK3CA/PPARG/HSPA8/ICAM1/PIK3CD/IRAK4/TRAF6/PIK3CB	5.63522619721702
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	30/933	119/9376	2.53343781242401	IL15/JUNB/FOS/JUN/CEBPB/MAP3K8/NFKBIA/MAP3K5/TNFRSF1A/VCAM1/CXCL2/BCL3/SOCS3/VEGFC/MMP14/MAPK10/PIK3R1/MAPK3/TNFAIP3/IL1B/CASP7/RPS6KA4/CCL2/IL6/PIK3CA/RHBDF2/ICAM1/PIK3CD/CSF1/PIK3CB	5.59606283655061
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	49/933	248/9376	1.98554783390381	FOS/JUN/HSP90AA1/ACTB/RHOB/ACTG1/TUBB2B/NFKBIA/MYC/TNFRSF1A/AHNAK2/MAPK10/ACTR3B/TLR4/RRAS/MAPK3/MYD88/PFN1/PKN1/ANXA2/IL1B/MYL9/CASP7/KIF5A/CASP4/VPS41/TUBB2A/CXCL8/GSDMD/FYCO1/TUBA1A/RPS3/ELMO1/RAB7B/IL6/CASP1/ARL8A/TUBB3/SNX18/TUBB4A/PAK3/LEF1/PIK3CA/PIK3CD/IRAK4/NOD1/ARHGEF26/TRAF6/PIK3CB	5.2287008822875
NA	NA	hsa04518	Integrin signaling	35/933	154/9376	2.28393257332164	C3/HGF/ACTB/LAMC1/LAMA3/ACTG1/LAMB1/THBS2/VCAM1/LAMA4/COL6A2/TNXB/VEGFC/PIK3R1/COL6A1/ITGA1/FBN1/ITGA5/FERMT2/FN1/IGF1R/TNC/VCL/THBS1/FERMT1/PARVB/PXN/NCK2/COL4A4/PIK3CA/ICAM1/PIK3CD/PIK3CB/FERMT3/VTN	5.34032986871197
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	33/933	142/9376	2.33540147638241	FOSB/JUNB/FOS/JUN/JUND/FOSL2/NFKBIA/TNFRSF1A/MITF/SOCS3/IFNGR2/MAPK10/PIK3R1/FYN/MAPK3/TGFBR2/IL1B/IFNGR1/IFNAR1/STAT2/ACP5/NFKB2/PPP3R1/PPP3CA/TGFB2/IFNAR2/PIK3CA/PPARG/PIK3CD/GAB2/CSF1/TRAF6/PIK3CB	5.33014660692729
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	33/933	142/9376	2.33540147638241	FOS/JUN/HSP90AA1/DUSP1/ACTB/MGST1/ACTG1/MAP3K5/TNFRSF1A/VCAM1/PRKAA2/MMP2/CAV2/NFE2L2/MAPK10/PIK3R1/GSTT2B/ASS1/CAV1/KLF2/SDC2/IL1B/PLAT/GSTA1/BMP4/CCL2/PIK3CA/BMPR2/ARHGEF2/MEF2C/ICAM1/PIK3CD/PIK3CB	5.33014660692729
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	41/933	196/9376	2.10215018483278	C3/ZFP36/HLA-C/FOS/JUN/STAT3/HLA-A/NFKBIA/HIF1A/MYC/TNFRSF1A/GNG4/CXCL2/IL6ST/MAPK10/MAPKAPK2/PIK3R1/MAPK3/CLEC2B/LYN/HLA-F/IFNGR1/IFNAR1/STAT2/CXCL8/FGF2/IL6/GNG12/PPP3R1/PPP3CA/IFNAR2/LEF1/EP300/PIK3CA/HLA-B/TLR3/ICAM1/PIK3CD/MICB/RPS27A/PIK3CB	5.18352906841034
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	35/933	157/9376	2.2402905496276	HLA-C/SERPINE1/GADD45A/HLA-A/FOXO1/IGFBP3/HIPK3/MYC/MAPKAPK2/PIK3R1/ZFP36L1/RRAS/MAPK3/TGFBR2/HLA-F/GADD45B/MRAS/CXCL8/CHEK2/IL6/TRAF3IP2/FOXO3/PPP3R1/PPP3CA/TGFB2/PIK3CA/GADD45G/HIPK2/HLA-B/SMAD3/CDKN2B/PIK3CD/SIRT1/ZFP36L2/PIK3CB	5.20966045662579
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	19/933	62/9376	3.07962521176918	INSR/SOD2/HSPA1B/HSPA1A/IRS2/FOXO1/ADCY1/PRKAA2/PIK3R1/ADCY3/CRYAB/IGF1R/FOXO3/PIK3CA/HSPA8/PIK3CD/SIRT1/PIK3CB/ADCY2	5.46123502966568
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	27/933	110/9376	2.46664717918737	INSR/STAT3/SERPINE1/EPAS1/LDHA/HIF1A/IFNGR2/RPS6/PIK3R1/TIMP1/TLR4/MAPK3/IFNGR1/IGF1R/ALDOA/IL6/HK2/CAMK2D/IL6R/EP300/PIK3CA/ENO1/PIK3CD/ENO2/CUL2/PIK3CB/PDK1	5.14344276384818
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	27/933	110/9376	2.46664717918737	ID2/ID4/CHRD/FST/DCN/MYC/GREM1/MAPK3/TGFBR2/TGIF1/FBN1/NBL1/GREM2/ID1/FMOD/BMP4/THBS1/BAMBI/LEMD3/TGFB2/EP300/BMPR2/SMAD7/SP1/SMAD3/SMAD6/CDKN2B	5.14344276384818
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	45/933	233/9376	1.94085257303727	LMOD1/ACTB/VIM/FBLN1/ZYX/FBLN2/SDC3/ACTG1/THBS2/DCN/SGCE/SYNPO2/SUN1/DES/COL6A2/PLEC/HSPG2/DIAPH2/PDLIM1/COL6A1/ANK2/ITGA1/JUP/FBN1/SDC2/NID2/ITGA5/FN1/PKP2/MYL9/TPM2/FMNL2/SNTB1/FHL3/VCL/THBS1/VCAN/COL4A4/ENO1/COL11A1/TMOD1/ENO2/SYNE3/NEB/MYOM2	4.83429605160301
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	16/933	50/9376	3.21577706323687	HGF/THBS2/VCAM1/TLR4/MYD88/SDC2/IL1B/CD81/CXCL8/THBS1/CCL2/IL6/LRP1/CD40/TGFB2/ICAM1	5.22205479396565
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	21/933	78/9376	2.70558166378102	C3/SERPING1/C1S/C1R/FOS/JUN/C2/MAPK10/TLR4/MAPK3/MYD88/ITGA5/IL1B/CASP7/CFL2/CXCL8/IL6/CASP1/IRAK4/NOD1/TRAF6	5.02809082829136
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	40/933	203/9376	1.98015829017049	JUN/HGF/ACTB/LAMC1/LAMA3/ZYX/ACTG1/LAMB1/THBS2/LAMA4/COL6A2/CAV2/TNXB/VEGFC/MAPK10/PIK3R1/FYN/MAPK3/CAV1/COL6A1/ITGA1/MYLK3/ITGA5/FN1/MYL9/IGF1R/TNC/ARHGAP5/VCL/THBS1/PARVB/PXN/PAK3/COL4A4/VAV3/PIK3CA/PPP1R12B/PIK3CD/PIK3CB/VTN	4.69317345030726
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	25/933	103/9376	2.4391512918969	LAMC1/LAMA3/LAMB1/HSPB1/ADCY1/LAMA4/CXCL2/GNAQ/PIK3R1/TLR4/GNA14/IL1B/FN1/GNAL/CXCL8/CD1D/VCL/RAB7B/IL6/PLCB3/TGFB2/COL4A4/PIK3CA/PIK3CD/PIK3CB	4.88194632006827
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	17/933	56/9376	3.05068136579391	C3/HSPA1B/HSPA1A/NFKBIA/CXCL2/CLK1/TLR4/MYD88/HSPD1/IL1B/CASP7/CXCL8/NFKB2/IL6/CASP1/EEF1G/HSPA8	5.11637428901542
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	22/933	88/9376	2.5123258306538	C3/SERPING1/CFD/C1S/C1R/C2/SERPINE1/MASP1/CFI/PROS1/CD55/TFPI/PROCR/A2M/CD59/PLAT/SERPINE2/CFH/F2RL2/CFB/VTN/F12	4.73809395228446
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	29/933	138/9376	2.11181011852059	FOS/JUN/ACTB/ACTG1/RPS6KA2/NFKBIA/MAPK10/GNAQ/ACTR3B/PIK3R1/TLR4/MAPK3/MYD88/ITGA5/PKN1/IL1B/FN1/CXCL8/ELMO1/CCL2/IL6/CASP1/PXN/VAV3/PIK3CA/PIK3CD/IRAK4/TRAF6/PIK3CB	4.37380334001508
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	35/933	180/9376	1.95403120161963	C3/PILRA/HLA-C/HLA-A/NFKBIA/TNFRSF1A/SOCS3/IFNGR2/HLA-DQA2/TNFSF14/PIK3R1/MYD88/TAP1/PTPN11/TNFRSF14/HLA-F/ITGA5/IL1B/IFNGR1/B2M/IFNAR1/STAT2/ZC3HAV1/CCL2/IL6/POU2F3/IFNAR2/PIK3CA/HLA-B/TLR3/PIK3CD/IRAK4/TRAF6/OAS2/PIK3CB	4.29613000681795
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	24/933	105/9376	2.29698361659776	JUN/NFKBIA/CBLB/BCL3/MAPK10/MAPKAPK2/PIK3R1/RRAS/MAPK3/PTPN11/IL1B/MRAS/STAT2/NFKB2/PLK3/IL6/CASP1/PPP3R1/PPP3CA/PIK3CA/CLEC4M/EGR3/PIK3CD/PIK3CB	4.44266856152798
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	41/933	224/9376	1.83938141172868	IL15/ZFP36/HLA-C/EGR1/FOS/JUN/IL15RA/TSPO/HLA-A/NFKBIA/ADCY1/MYC/TNFRSF1A/HLA-DQA2/MAPK10/PIK3R1/ADCY3/MAPK3/TGFBR2/HLA-F/SRF/B2M/NFKB2/CHEK2/IL6/CD40/NFYB/PPP3R1/PPP3CA/TGFB2/EP300/PIK3CA/HLA-B/ICAM1/SMAD3/CDKN2B/PIK3CD/STAT5A/ETS2/PIK3CB/ADCY2	4.22671939147131
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	25/933	112/9376	2.24314806308375	HSPA1B/HSPA1A/LAMC1/STAT3/LAMA3/LAMB1/LDLR/NFKBIA/TNFRSF1A/LAMA4/IFNGR2/HLA-DQA2/MAPK10/TLR4/MAPK3/MYD88/NFKBIB/IFNGR1/IL10RB/PPIF/CD40/TGFB2/HSPA8/IRAK4/TRAF6	4.39957434824372
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	59/933	362/9376	1.63786987854778	INSR/OSMR/MCL1/HSP90AA1/HGF/NR4A1/LAMC1/FGF7/LAMA3/LAMB1/THBS2/CSF3R/MYC/GNG4/LAMA4/PRKAA2/FGF10/COL6A2/TNXB/VEGFC/RPS6/NTF3/PIK3R1/TLR4/MAPK3/PRLR/COL6A1/NTRK1/MAGI1/ITGA1/ITGA5/PKN1/FN1/IFNAR1/IGF1R/PPP2R3A/TNC/KITLG/THBS1/FGF2/IL6/GNG12/FOXO3/FLT3LG/IL6R/IFNAR2/COL4A4/SGK3/NGF/PIK3CA/PIK3CD/PCK2/BDNF/CSF1/NGFR/PRL/PIK3CB/VTN/NRTN	4.11439201296734
Human Diseases	Infectious disease: viral	hsa05162	Measles	28/933	136/9376	2.0689742134796	HSPA1B/FOS/HSPA1A/JUN/STAT3/NFKBIA/CBLB/MAPK10/PIK3R1/TLR4/TNFAIP3/MYD88/NFKBIB/IL1B/IFNAR1/STAT2/IL6/MX2/IFNAR2/PIK3CA/CLEC4M/HSPA8/PIK3CD/IRAK4/STAT5A/TRAF6/OAS2/PIK3CB	4.17425295231298
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	24/933	109/9376	2.21269063984188	FOS/JUN/HSP90AA1/STAT3/RORA/NFKBIA/HIF1A/IL6ST/IFNGR2/HLA-DQA2/MAPK10/MAPK3/GATA3/TGFBR2/NFKBIB/IL1B/IFNGR1/IL6/PPP3R1/PPP3CA/IL6R/IL1RAP/SMAD3/STAT5A	4.23322895856495
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	24/933	109/9376	2.21269063984188	INSR/IRS2/STAT3/FOXO1/RPS6KA2/NFKBIA/PTPRF/TNFRSF1A/PRKAA2/SOCS3/MAPK10/SLC27A6/PIK3R1/PTPN11/SLC27A3/IL6/PYGL/GFPT2/PYGM/PIK3CA/PPARGC1A/PIK3CD/PCK2/PIK3CB	4.23322895856495
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	35/933	187/9376	1.88088564861782	JUN/HSP90AA1/NAMPT/IFI16/CTSB/GBP2/NFKBIA/ANTXR2/CXCL2/GBP1/MAPK10/TLR4/MAPK3/TNFAIP3/GABARAPL1/MYD88/TANK/GBP3/NFKBIB/PKN1/IL1B/IFNAR1/STAT2/CASP4/CXCL8/GSDMD/CCL2/IL6/CASP1/PLCB3/IFNAR2/IRAK4/NOD1/TRAF6/OAS2	4.04468102366982
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	31/933	160/9376	1.9470525187567	HLA-C/HLA-A/SDC3/PTPRF/CDH4/VCAM1/NLGN4X/CDH3/NLGN1/NCAM2/PTPRM/HLA-DQA2/LRRC4C/PTPRD/NRXN1/SDC2/HLA-F/NRCAM/CADM1/CD40/NTNG1/VCAN/CLDN10/CD226/CNTNAP1/NCAM1/HLA-B/ICAM1/PVR/NEGR1/ALCAM	4.01643633385532
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	32/933	168/9376	1.91415301383147	IL15/PIM1/OSMR/MCL1/AOX1/STAT3/IL15RA/CSF3R/MYC/IL6ST/SOCS3/IFNGR2/PIK3R1/IL13RA1/PRLR/CLCF1/PTPN11/IFNGR1/IFNAR1/STAT2/IL10RB/THPO/IL6/SOCS5/IL6R/IFNAR2/EP300/PIK3CA/PIK3CD/STAT5A/PRL/PIK3CB	3.97437595235557
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	38/933	212/9376	1.80129021820461	INSR/HGF/ACTB/FGF7/APBB1IP/ACTG1/RASGRP2/ADCY1/DOCK4/FGF10/VEGFC/SIPA1L2/GNAQ/PIK3R1/ADCY3/RRAS/MAPK3/EVL/P2RY1/PFN1/MAGI1/MRAS/ID1/IGF1R/PRKCI/KITLG/MAGI3/THBS1/FGF2/PLCB3/NGF/VAV3/PIK3CA/PIK3CD/CSF1/NGFR/PIK3CB/ADCY2	3.92277407760225
NA	NA	hsa04519	Cadherin signaling	62/933	404/9376	1.54221981683699	GABRA2/ACTB/VIM/ACTG1/NFKBIA/LHFPL6/GABRE/CDH4/DES/CDH3/MAPK10/ACTR3B/RRAS/MAPK3/EVL/PCDH18/DCHS2/WNT2/JUP/PKP2/PCDH10/MRAS/IGF1R/PCDHB10/WNT5B/AMOTL2/VCL/PCDHGA10/LATS2/NCSTN/PCDHB11/YAP1/PCDHB16/PCDHB9/PCDHB2/CDH13/TEAD1/LEF1/EP300/PCDHB12/WASF1/VAV3/PCDHB15/FMN1/PCDHB4/LRP5/CDH11/MYO1E/FAT4/PCDHB3/PCDHGA8/CDH6/PCDHA9/PCDHA4/TEAD4/PCDHGA6/FZD3/PCDHB7/PCDHA5/FAT1/WNT5A/PCDH7	3.70339044303637
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	36/933	201/9376	1.79987522196093	ID2/NFKBIZ/CEBPB/GADD45A/FOXO1/IGFBP3/ZBTB16/MYC/WT1/MITF/PBX1/BCL6/NUPR1/PROM1/GRIA3/TGFBR2/NTRK1/RUNX1T1/JUP/AFF1/PLAT/GADD45B/IGF1R/CXCL8/ETV7/MEIS1/ELANE/KLF3/IL6/CD40/GADD45G/SP1/PPARG/HPGD/MEF2C/NGFR	3.81061700672102
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	18/933	78/9376	2.31906999752659	ACTB/ACTG1/CAV2/ACTR3B/PIK3R1/CAV1/ITGA5/FN1/VCL/ELMO1/HCLS1/PXN/WASF1/PIK3CA/PIK3CD/ARHGEF26/GAB1/PIK3CB	3.88864625909186
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	35/933	200/9376	1.75862808145766	FOS/JUN/ACTB/ACTG1/TUBB2B/NFKBIA/TNFRSF1A/MAPK10/ACTR3B/TLR4/FYN/MAPK3/MYD88/PTPN11/NFKBIB/IL1B/CASP7/CASP4/TUBB2A/CXCL8/TUBA1A/RPS3/HCLS1/IL6/CASP1/TUBB3/CLDN10/TUBB4A/PAK3/NCK2/WASF1/ARHGEF2/MYO1E/IRAK4/TRAF6	3.60491704523507
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	24/933	120/9376	2.00986066452304	JUN/RPS6KA2/NFKBIA/MAP3K5/NTF3/MAPK10/MAPKAPK2/PIK3R1/MAPK3/IRAK3/NTRK1/PTPN11/NFKBIB/CAMK2D/FOXO3/NGF/PIK3CA/PIK3CD/IRAK4/BDNF/GAB1/NGFR/TRAF6/PIK3CB	3.70099477225634
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	29/933	157/9376	1.85624074112001	CEBPB/HIF1A/PROS1/PBX1/BSG/MAPKAPK2/MAPK3/MFGE8/LIPA/AXL/PTPN11/ANO6/MEGF10/CASP7/VPS41/DUSP8/ELMO1/RAB7B/THBS1/LRP1/CASP1/SLC16A1/CAMK2D/PTGER2/PPARG/ATP8A2/SIRT1/DUSP16/DUSP5	3.59651497119302
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	31/933	173/9376	1.80074221387903	ACTB/DNAJB1/ACTG1/NFKBIA/TNFRSF1A/SOCS3/IFNGR2/HLA-DQA2/PIK3R1/TLR4/MAPK3/MYD88/NFKBIB/IL1B/IFNGR1/IFNAR1/STAT2/CXCL8/CCL2/IL6/CASP1/MX2/IFNAR2/EP300/PIK3CA/TLR3/ICAM1/PIK3CD/IRAK4/OAS2/PIK3CB	3.53369555676882
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	26/933	137/9376	1.90716705392698	MCL1/FOS/JUN/ACTB/GADD45A/ACTG1/CTSB/NFKBIA/MAP3K5/TNFRSF1A/MAPK10/PIK3R1/MAPK3/NTRK1/CTSS/CASP7/GADD45B/CTSO/TUBA1A/CTSC/NGF/PIK3CA/GADD45G/PIK3CD/PMAIP1/PIK3CB	3.55560194247948
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	22/933	109/9376	2.02829975318839	FOS/JUN/MAP3K8/NFKBIA/MAPK10/PIK3R1/TLR4/MAPK3/MYD88/IL1B/IFNAR1/STAT2/CXCL8/IL6/CD40/IFNAR2/PIK3CA/TLR3/PIK3CD/IRAK4/TRAF6/PIK3CB	3.58956204514769
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	35/933	205/9376	1.71573471361723	HLA-C/JUN/VIM/STAT3/GADD45A/HLA-A/NFKBIA/MYC/CD44/HLA-DQA2/MAPK10/PIK3R1/TNFAIP3/MYD88/LYN/TAP1/NFKBIB/HLA-F/GADD45B/B2M/IFNAR1/STAT2/NFKB2/IL6/CD40/IFNAR2/PIK3CA/GADD45G/HLA-B/ICAM1/PIK3CD/IRAK4/TRAF6/OAS2/PIK3CB	3.44428222617152
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	19/933	90/9376	2.12151959032988	FOS/JUN/STAT3/NFKBIA/HIF1A/IFNGR2/PIK3R1/TLR4/MAPK3/MYD88/PTPN11/NFKBIB/IFNGR1/PPP3R1/PPP3CA/PIK3CA/PIK3CD/TRAF6/PIK3CB	3.55379068426395
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	21/933	105/9376	2.00986066452304	CXCL12/GADD45A/NFKBIA/TNFRSF1A/VCAM1/CXCL2/TNFSF14/TLR4/TNFAIP3/MYD88/LYN/IL1B/GADD45B/CXCL8/NFKB2/CD40/CCL13/GADD45G/ICAM1/IRAK4/TRAF6	3.45916183395528
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	46/933	298/9376	1.55123474107483	CXCL12/IL15/OSMR/IL32/IL15RA/CXCL13/CSF3R/TNFRSF1A/IL17RB/CXCL2/IL6ST/IFNGR2/TNFSF14/IL13RA1/PRLR/TGFBR2/TNFRSF21/CLCF1/TNFRSF14/IL1B/IFNGR1/IFNAR1/IL10RB/CXCL8/BMP4/THPO/CCL2/IL6/CD40/CCL13/RELT/TNFRSF12A/IL1RL1/IL6R/TGFB2/IFNAR2/CXCL14/NGF/IL1RAP/CCL8/BMPR2/TNFSF9/CSF1/NGFR/PRL/CCL26	3.21460554167221
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	12/933	47/9376	2.56577957173155	INSR/IRS2/SOCS3/MAPK10/PIK3R1/MAPK3/CACNA1C/CACNA1B/HK2/PIK3CA/PIK3CD/PIK3CB	3.57717404129078
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	22/933	116/9376	1.90590235428909	SLC38A2/ADCY1/GNG4/GLUL/HOMER1/GNAQ/ADCY3/MAPK3/GRIA3/CACNA1C/GRIN3A/GRIK2/GRM8/GNG12/PLA2G4C/PLD1/PPP3R1/PPP3CA/PLCB3/GRIA1/GRM7/ADCY2	3.26349502537836
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	25/933	138/9376	1.82052596424189	INSR/IRS2/FOXO1/PTPRF/CBLB/PRKAA2/SOCS3/RPS6/MAPK10/PIK3R1/MAPK3/SORBS1/RHOQ/FLOT1/PRKCI/PHKG1/HK2/TRIP10/PYGL/PYGM/PIK3CA/PPARGC1A/PIK3CD/PCK2/PIK3CB	3.22790658511514
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	17/933	82/9376	2.0833921522495	HSPA1B/HLA-C/HSPA1A/HSP90AA1/HLA-A/CTSB/HLA-DQA2/PSME1/TAP1/HSPA2/HLA-F/CTSS/B2M/PSME2/NFYB/HLA-B/HSPA8	3.27543769636338
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	29/933	170/9376	1.71429291974024	HGF/ACTB/MGST1/GADD45A/ACTG1/MYC/NFE2L2/PIK3R1/MAPK3/GSTT2B/TGFBR2/WNT2/GADD45B/IGF1R/GSTA1/WNT5B/TXNRD1/TGFB2/LEF1/PIK3CA/GADD45G/LRP5/SMAD3/PIK3CD/FZD3/DPF3/GAB1/WNT5A/PIK3CB	3.12423278988276
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	27/933	155/9376	1.75052380458459	C3/HLA-C/C1R/ACTB/COLEC11/HLA-A/ACTG1/THBS2/TUBB2B/PLA2R1/HLA-DQA2/TLR4/TAP1/HLA-F/ITGA5/CTSS/STX12/TUBB2A/TUBA1A/RAB7B/THBS1/ATP6V1C1/TUBB3/TUBB4A/ATP6V1B2/CLEC4M/HLA-B	3.13198284751952
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	26/933	148/9376	1.76541815127024	FOS/JUN/FGF7/GADD45A/MYC/FGF10/PIK3R1/MAPK3/WNT2/HEY2/GADD45B/IGF1R/NFKB2/WNT5B/FGF2/PGR/LEF1/NOTCH2/PIK3CA/GADD45G/SP1/LRP5/PIK3CD/FZD3/WNT5A/PIK3CB	3.11999492189562
Organismal Systems	Immune system	hsa04611	Platelet activation	23/933	126/9376	1.83439663825516	ACTB/APBB1IP/ACTG1/RASGRP2/ADCY1/GNAQ/PIK3R1/ADCY3/FYN/MAPK3/LYN/P2RY1/MYLK3/PRKCI/PLA2G4C/PLCB3/PIK3CA/PRKG1/PIK3CD/PTGIR/PIK3CB/FERMT3/ADCY2	3.1344764937153
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	18/933	90/9376	2.00986066452304	INSR/SOD2/IRS2/FOXO1/ADCY1/PRKAA2/PIK3R1/ADCY3/RB1CC1/IGF1R/FOXO3/PIK3CA/PPARG/PPARGC1A/PIK3CD/SIRT1/PIK3CB/ADCY2	3.1999739040947
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	36/933	227/9376	1.59372211283766	CXCL12/HLA-C/AKAP13/STAT3/HLA-A/NFKBIA/ADCY1/MYC/TNFRSF1A/GNG4/PTGER3/GNAQ/PIK3R1/ADCY3/MAPK3/TAP1/HLA-F/IL1B/B2M/IL10RB/CXCL8/CCL2/IL6/GNG12/PPP3R1/PXN/PPP3CA/PTGER2/IL6R/PLCB3/PIK3CA/SP1/HLA-B/PIK3CD/PIK3CB/ADCY2	3.01014491861319
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	15/933	70/9376	2.1534221405604	JUN/HGF/EPAS1/HIF1A/PIK3R1/MAPK3/PTPN11/PAK3/TGFB2/EP300/PIK3CA/PIK3CD/CUL2/GAB1/PIK3CB	3.21983669120681
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	16/933	77/9376	2.08816692417979	GADD45A/NFKBIA/MYC/PIK3R1/MAPK3/TGFBR2/PTPN11/GADD45B/TGFB2/PIK3CA/GADD45G/SMAD3/PIK3CD/GAB2/STAT5A/PIK3CB	3.18713768260345
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	26/933	150/9376	1.74187924258664	HGF/FGF7/GADD45A/MYC/FGF10/PIK3R1/MAPK3/TGFBR2/WNT2/JUP/GADD45B/ABCB1/WNT5B/FGF2/TGFB2/LEF1/PIK3CA/GADD45G/LRP5/SMAD3/CDKN2B/PIK3CD/FZD3/GAB1/WNT5A/PIK3CB	3.04473983850783
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	39/933	253/9376	1.54910209320946	C3/JUN/ACTB/FOXO1/ACTG1/NFKBIA/TNFRSF1A/CD44/MAPK10/ACTR3B/PIK3R1/TLR4/MAPK3/MYD88/PFN1/NFKBIB/ITGA5/IL1B/MYL9/CASP4/CXCL8/VCL/ELMO1/HCLS1/CASP1/PLCD1/HK2/FOXO3/PXN/PLCB3/WASF1/PIK3CA/ARHGEF2/FNBP1L/PIK3CD/NOD1/RPS27A/TRAF6/PIK3CB	2.9432190639321
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	19/933	99/9376	1.92865417302716	HTR2A/ADCY1/HRH1/MAPK10/GNAQ/PIK3R1/ADCY3/NTRK1/IL1B/PLA2G4C/CAMK2D/PTGER2/PLCB3/NGF/PIK3CA/IL1RAP/PIK3CD/PIK3CB/ADCY2	3.08777679469382
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	37/933	238/9376	1.5622866509948	INSR/PLA2G2A/HGF/FGF7/RASGRP2/GNG4/FGF10/VEGFC/NTF3/MAPK10/PIK3R1/RRAS/MAPK3/NTRK1/PTPN11/RASAL2/MRAS/IGF1R/KITLG/FGF2/RASA3/GNG12/PLA2G4C/PLD1/FLT3LG/PAK3/NGF/PIK3CA/HTR7/PIK3CD/GAB2/BDNF/CSF1/GAB1/NGFR/ETS2/PIK3CB	2.92077928853927
Genetic Information Processing	Translation	hsa03010	Ribosome	35/933	222/9376	1.58434962293483	RPL29/RPL39/MRPS24/RPL36A/RPS7/RPL12/RPS3A/RPS18/RPS6/RPL22L1/RPL13/RPS15/RPL9/RPL7/RPS24/RPL26/RPS19/RPL34/RPS15A/MRPL42/RPS9/RPL8/RPS3/RPL35/MRPS27/RPS2/RPSA/MRPS30/RPL17/RPS5/MRPL12/RPL18A/RPS12/RPS10/RPS27A	2.92901682749306
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	14/933	65/9376	2.16446533102482	NR4A1/STAR/LDLR/ADCY1/PBX1/GNAQ/ADCY3/PDE8B/CACNA1C/PLCB3/SP1/POMC/KCNA4/ADCY2	3.1315773517393
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	18/933	93/9376	1.94502644953843	LAMC1/GADD45A/LAMA3/LAMB1/NFKBIA/MYC/FHIT/LAMA4/PIK3R1/FN1/GADD45B/COL4A4/PIK3CA/GADD45G/CDKN2B/PIK3CD/TRAF6/PIK3CB	3.04452348343907
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	13/933	59/9376	2.21425327447454	INSR/IRS2/NPR1/ADCY1/PTGER3/PIK3R1/ADCY3/ABHD5/PIK3CA/PRKG1/PIK3CD/PIK3CB/ADCY2	3.11010682874933
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	18/933	94/9376	1.92433467879866	FOSB/FOS/JUN/JUND/HSP90AA1/CEBPB/NFKBIA/IL17RB/CXCL2/MAPK10/MAPK3/TNFAIP3/IL1B/CXCL8/CCL2/IL6/TRAF3IP2/TRAF6	2.99399077045803
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	17/933	87/9376	1.96365697108573	FOS/JUN/GADD45A/MYC/MAPK10/PIK3R1/MAPK3/TGFBR2/GADD45B/TGFB2/LEF1/PIK3CA/GADD45G/SMAD3/PIK3CD/PMAIP1/PIK3CB	3.00175800685771
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	31/933	193/9376	1.61413680311436	CXCL12/STAT3/RASGRP2/NFKBIA/CXCL13/ADCY1/GNG4/CXCL2/GNAQ/PIK3R1/ADCY3/MAPK3/LYN/NFKBIB/STAT2/CXCL8/ELMO1/CCL2/GNG12/CCL13/FOXO3/PXN/PLCB3/CXCL14/VAV3/PIK3CA/CCL8/PIK3CD/PIK3CB/CCL26/ADCY2	2.86569226679076
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	27/933	163/9376	1.66460852583197	FOS/JUN/STAT3/NFKBIA/MYC/HSPG2/MAPK10/PIK3R1/TLR4/MAPK3/TGFBR2/MYD88/IFNAR1/STAT2/CXCL8/IL6/TGFB2/EP300/PIK3CA/TLR3/SMAD3/EGR3/PIK3CD/IRAK4/STAT5A/TRAF6/PIK3CB	2.84536012056051
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	17/933	89/9376	1.91952984813999	LAMC1/LAMA3/LAMB1/THBS2/LAMA4/COL6A2/CD44/HSPG2/TNXB/COL6A1/ITGA1/ITGA5/FN1/TNC/THBS1/COL4A4/VTN	2.89735144047165
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	25/933	149/9376	1.6861247185596	INSR/ADCY1/PIK3R1/ADCY3/FYN/RRAS/MAPK3/PTPN11/MRAS/CXCL8/KITLG/AGPAT4/GRM8/PLA2G4C/PLD1/PLCB3/PIK3CA/AVPR1A/PIK3CD/GAB2/DGKI/GRM7/GAB1/PIK3CB/ADCY2	2.80636402834414
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	12/933	55/9376	2.19257527038878	ACER3/PSAP/UGCG/CERS2/NEU1/SAMD8/HEXB/GALC/SGMS1/B4GALT5/SGPP1/CERS6	2.94858706237231
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	14/933	69/9376	2.03898907995091	MAOB/FOSB/FOS/JUN/SLC18A2/GRIA3/CACNA1C/GRIN3A/ARC/CAMK2D/PPP3R1/PPP3CA/GRIA1/SIRT1	2.87944466419587
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	14/933	70/9376	2.00986066452304	HLA-C/ACTB/HLA-A/ACTG1/SGCE/CD55/HLA-DQA2/FYN/CAV1/HLA-F/SNTB1/CD40/HLA-B/ICAM1	2.81907751402966
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	9/933	37/9376	2.44442513252803	APOL1/VCAM1/LAMA4/GNAQ/MYD88/IL1B/IL6/PLCB3/ICAM1	2.92633321115064
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	15/933	78/9376	1.93255833127216	C3/FOS/JUN/NFKBIA/IFNGR2/HLA-DQA2/TLR4/MAPK3/MYD88/NFKBIB/IL1B/IFNGR1/TGFB2/IRAK4/TRAF6	2.74920168989237
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	14/933	71/9376	1.98155276783962	FOS/STAT3/SOCS3/MAPK10/PIK3R1/MAPK3/PRLR/FOXO3/SOCS5/PIK3CA/PIK3CD/STAT5A/PRL/PIK3CB	2.75970527118577
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	25/933	154/9376	1.63138040951546	FOS/JUN/ACTB/NPR1/ACTG1/ADCY1/CD38/PRKAA2/GNAQ/ADCY3/MAPK3/EEF2/CACNA1C/MYLK3/MYL9/RGS2/PLA2G4C/CAMK2D/PPP3R1/PPP3CA/PLCB3/CACNB2/MEF2C/PPP1R12B/ADCY2	2.62613452568768
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	18/933	101/9376	1.79096494858489	EDNRB/ADCY1/MITF/GNAQ/ADCY3/MAPK3/WNT2/WNT5B/KITLG/CAMK2D/PLCB3/LEF1/EP300/ASIP/FZD3/POMC/WNT5A/ADCY2	2.65667868564767
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	15/933	80/9376	1.88424437299035	HGF/STAT3/RPS6/PIK3R1/MAPK3/AXL/IGF1R/FGF2/IL6/FOXO3/IL6R/PIK3CA/PIK3CD/GAB1/PIK3CB	2.64026370858907
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	17/933	95/9376	1.79829638404693	CXCL12/IL15/FOS/JUN/CXCL2/HLA-DQA2/TLR4/IL1B/CXCL8/ACP5/CCL2/IL6/ATP6V1C1/TGFB2/ATP6V1B2/ICAM1/CSF1	2.59960069166381
Human Diseases	Cancer: specific types	hsa05218	Melanoma	14/933	73/9376	1.92726365091251	HGF/FGF7/GADD45A/MITF/FGF10/PIK3R1/MAPK3/GADD45B/IGF1R/FGF2/PIK3CA/GADD45G/PIK3CD/PIK3CB	2.64381596396647
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	14/933	73/9376	1.92726365091251	HGF/STAT3/GADD45A/FHIT/PIK3R1/MAPK3/GADD45B/KIF5A/FOXO3/PIK3CA/GADD45G/PIK3CD/STAT5A/PIK3CB	2.64381596396647
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	12/933	60/9376	2.00986066452304	HSPB1/SH2D2A/MAPKAPK2/PIK3R1/MAPK3/PLA2G4C/PPP3R1/PXN/PPP3CA/PIK3CA/PIK3CD/PIK3CB	2.6085574555984
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	23/933	144/9376	1.60509705847326	ID2/ID4/STAT3/KLF4/PCGF5/MYC/IL6ST/PIK3R1/MAPK3/WNT2/ID1/IGF1R/WNT5B/BMP4/MEIS1/FGF2/PIK3CA/BMPR2/SMAD3/PIK3CD/FZD3/WNT5A/PIK3CB	2.43240818034191
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	13/933	68/9376	1.9211903410882	PIM1/STAT3/ZBTB16/MYC/PIK3R1/MAPK3/RUNX1T1/JUP/LEF1/PIK3CA/PIK3CD/STAT5A/PIK3CB	2.53427482911502
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	26/933	169/9376	1.54604666501773	IRS2/CTSB/HIF1A/PRKAA2/OPTN/MAPK10/PIK3R1/RRAS/MAPK3/GABARAPL1/RB1CC1/VMP1/TANK/DEPTOR/MRAS/IGF1R/VPS41/SH3GLB1/C9orf72/RAB7B/PIK3CA/PIK3CD/EPG5/RPS27A/TRAF6/PIK3CB	2.38117933652383
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	20/933	122/9376	1.64742677419922	FOS/JUN/MAP3K8/NFKBIA/CBLB/MAPK10/PIK3R1/FYN/MAPK3/PTPN11/NFKBIB/PPP2R3A/PPP3R1/PPP3CA/PAK3/NCK2/VAV3/PIK3CA/PIK3CD/PIK3CB	2.39267597473391
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	20/933	122/9376	1.64742677419922	JUNB/FOS/IRS2/STAT3/IGFBP3/ADCY1/SOCS3/MAPK10/GNAQ/PIK3R1/ADCY3/MAPK3/CACNA1C/PLCB3/EP300/PIK3CA/PIK3CD/STAT5A/PIK3CB/ADCY2	2.39267597473391
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	14/933	77/9376	1.82714605865731	STAT3/GADD45A/MAPK10/PIK3R1/MAPK3/TGFBR2/GADD45B/PLD1/TGFB2/PIK3CA/GADD45G/SMAD3/PIK3CD/PIK3CB	2.42263233147867
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	17/933	100/9376	1.70838156484459	CXCL12/CXCL13/TNFRSF1A/CXCL2/IL6ST/TNFSF14/TNFRSF14/IL10RB/CXCL8/CCL2/IL6/CCL13/IL6R/CXCL14/CCL8/CSF1/CCL26	2.36736349192512
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	45/933	333/9376	1.35801396251557	HLA-C/LAMC1/HLA-A/LAMA3/FOXO1/LAMB1/THBS2/TNFRSF1A/LAMA4/COL6A2/TNXB/PIK3R1/MAPK3/COL6A1/MAGI1/ITGA1/WNT2/HEY2/HLA-F/MAML3/ITGA5/FN1/IFNAR1/STAT2/PRKCI/PPP2R3A/TNC/WNT5B/THBS1/ATP6V1C1/PXN/MX2/IFNAR2/EP300/COL4A4/NOTCH2/PIK3CA/ATP6V1B2/HLA-B/TLR3/PIK3CD/FZD3/WNT5A/PIK3CB/VTN	2.21128072936772
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	16/933	93/9376	1.72891239958972	INSR/ACTB/ACTG1/PTPRF/PTPRM/FYN/MAPK3/SORBS1/TGFBR2/MYL9/IGF1R/VCL/LEF1/EP300/WASF1/SMAD3	2.34828445172588
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	16/933	93/9376	1.72891239958972	EGR1/JUN/ADCY1/MMP2/MMP14/MAPK10/GNAQ/ADCY3/MAPK3/CACNA1C/MAP3K4/PLA2G4C/CAMK2D/PLD1/PLCB3/ADCY2	2.34828445172588
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	27/933	181/9376	1.49906734646746	C3/CEBPB/TNFRSF1A/PLA2R1/IFNGR2/HLA-DQA2/MAPK10/TLR4/MAPK3/MYD88/HSPD1/CTSS/IL1B/IFNGR1/IL10RB/PLK3/CEBPG/IL6/CAMK2D/NFYB/PPP3R1/PPP3CA/TGFB2/EP300/CLEC4M/IRAK4/TRAF6	2.25372354250487
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	7/933	29/9376	2.42569390545885	DCHS2/CSNK1E/LATS2/YAP1/TEAD1/FAT4/TEAD4	2.55603758828183
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	24/933	157/9376	1.53619923403035	ID2/ACTB/SERPINE1/NKD2/ACTG1/MYC/TGFBR2/WNT2/CSNK1E/ID1/PRKCI/WNT5B/BMP4/LATS2/YAP1/TGFB2/TEAD1/LEF1/BMPR2/SMAD7/SMAD3/TEAD4/FZD3/WNT5A	2.25222706666571
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	4/933	12/9376	3.34976777420507	NCAM2/NCAM1/CLEC4M/NGFR	2.70746548768962
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	8/933	37/9376	2.17282234002491	GADD45A/MYC/MAPK3/NTRK1/GADD45B/LEF1/GADD45G/PPARG	2.37607951226071
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	22/933	144/9376	1.53531022984399	C3/C2/FOXO1/NFKBIA/MAP3K5/TNFRSF1A/CXCL2/PRKAA2/ADH5/MAPK10/TLR4/MYD88/IL1B/CXCL8/IL6/FOXO3/LEF1/PPARGC1A/SIRT1/IRAK4/TRAF6/ADH1C	2.15187458583682
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	12/933	66/9376	1.82714605865731	JUN/STAT3/RORA/IFNGR2/HLA-DQA2/TLR4/GATA3/IL1B/IFNGR1/IL6/TGFB2/SMAD3	2.24159628091416
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	26/933	178/9376	1.46787576622469	WIF1/JUN/DKK1/NKD2/MYC/TLE2/MAPK10/WNT2/CSNK1E/GPC4/SERPINF1/WNT5B/ROR2/BAMBI/CAMK2D/PPP3R1/PPP3CA/PLCB3/LEF1/EP300/LRP5/SMAD3/SIRT1/FZD3/WNT5A/TLE3	2.09494157365515
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	11/933	59/9376	1.87359892455538	GADD45A/MYC/PIK3R1/MAPK3/GADD45B/FOXO3/LEF1/PIK3CA/GADD45G/PIK3CD/PIK3CB	2.23757764377742
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	10/933	52/9376	1.93255833127216	INSR/STAR/LDLR/ADCY1/ADCY3/HSD17B7/IGF1R/PLA2G4C/AKR1C3/ADCY2	2.24158189992197
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	8/933	38/9376	2.1156428047611	UAP1/GALK1/HEXB/HK2/GFPT2/GALK2/RENBP/AMDHD2	2.29069937739201
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	8/933	38/9376	2.1156428047611	NNMT/AOX1/NAMPT/ENPP1/CD38/NT5E/BST1/SIRT1	2.29069937739201
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	16/933	98/9376	1.64070258328412	GSN/ACTR3B/PIK3R1/MAPK3/LIMK2/LYN/CFL2/MARCKS/PLA2G4C/PLD1/WASF1/VAV3/PIK3CA/PIK3CD/GAB2/PIK3CB	2.11943642655792
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	20/933	130/9376	1.54604666501773	FOS/JUN/EDNRB/NFKBIA/ADCY1/GNG4/MMP2/VEGFC/MAPK10/PIK3R1/ADCY3/MAPK3/TGFBR2/GNG12/PLCB3/COL4A4/PIK3CA/PIK3CD/PIK3CB/ADCY2	2.08402323203406
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	19/933	122/9376	1.56505543548926	ACTB/FOXO1/ACTG1/HIF1A/MYC/DIO3/PIK3R1/MAPK3/MED13L/MED24/BMP4/DIO2/PLCD1/PLCB3/EP300/NOTCH2/PIK3CA/PIK3CD/PIK3CB	2.08825865528992
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	30/933	214/9376	1.40878083961896	HLA-C/FOS/JUN/HLA-A/NFKBIA/TNFRSF1A/GNG4/MAPK10/GNAQ/PIK3R1/TLR4/MAPK3/MYD88/LIMK2/TAP1/HLA-F/CFL2/B2M/GNG12/CUL4B/PPP3R1/PXN/PPP3CA/PAK3/PIK3CA/HLA-B/PIK3CD/IRAK4/TRAF6/PIK3CB	2.01085307566957
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	15/933	91/9376	1.65647856966185	FOS/JUN/NFKBIA/PIK3R1/MAPK3/LYN/NFKBIB/CD81/IFITM1/PPP3R1/PPP3CA/VAV3/PIK3CA/PIK3CD/PIK3CB	2.09183950703936
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	32/933	232/9376	1.38611080311934	CXCL12/ACTB/FGF7/ACTG1/FGF10/GSN/ACTR3B/PIK3R1/RRAS/MAPK3/DIAPH2/LIMK2/PFN1/ITGA1/MYLK3/ITGA5/FN1/MYL9/CFL2/MRAS/VCL/FGF2/GNG12/PXN/INSRR/PAK3/WASF1/VAV3/PIK3CA/PPP1R12B/PIK3CD/PIK3CB	1.97954738592467
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	21/933	140/9376	1.50739549839228	EGR1/SERPINE1/ADCY1/GNG4/PRKAA2/RPS6/GNAQ/ADCY3/RRAS/MAPK3/KLF2/MYLK3/PLAT/MRAS/SLC8A1/GNG12/PLCB3/PPARGC1A/MEF2C/SMAD3/ADCY2	2.01069746784417
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	34/933	250/9376	1.36670525187567	LAMP5/CTSB/MITF/NCOA7/BLOC1S1/CD68/TPP1/PSAP/IDUA/LIPA/DEPTOR/NEU1/PPT1/CTSS/CTSA/VPS41/HEXB/CTSO/ACP5/CTSC/OSBP/GNS/ATP6V1C1/ARL8A/GALC/OSTM1/VPS13A/SUMF1/OSBPL5/CLN3/ATP6V1B2/TLR3/SGSH/MANBA	1.95355196217075
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	16/933	100/9376	1.60788853161844	CSF3R/CD38/CD55/CD44/HLA-DQA2/ITGA1/CD59/ITGA5/IL1B/CD1D/KITLG/THPO/IL6/FLT3LG/IL6R/CSF1	2.03152254142748
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	23/933	158/9376	1.46287326848196	INSR/RPS6KA2/TNFRSF1A/PRKAA2/RPS6/PIK3R1/MAPK3/WNT2/DEPTOR/CLIP1/IGF1R/WNT5B/NPRL3/ATP6V1C1/PRR5L/PIK3CA/ATP6V1B2/LRP5/PIK3CD/FZD3/WNT5A/PIK3CB/FNIP2	1.95051977401926
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	19/933	125/9376	1.52749410503751	SPTSSA/MAP3K5/TNFRSF1A/MAPK10/GNAQ/PIK3R1/FYN/MAPK3/CERS2/PPP2R3A/PLD1/PLCB3/PIK3CA/SGMS1/SGPP1/CERS6/PIK3CD/GAB2/PIK3CB	1.97358730103405
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	15/933	93/9376	1.62085537461536	FOS/JUN/NFKBIA/IFNGR2/HLA-DQA2/MAPK10/MAPK3/GATA3/NFKBIB/MAML3/IFNGR1/PPP3R1/PPP3CA/NOTCH2/STAT5A	2.00016493586929
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	12/933	70/9376	1.72273771244832	IRS2/STAT3/NFKBIA/TNFRSF1A/PRKAA2/SOCS3/MAPK10/PTPN11/NFKBIB/PPARGC1A/PCK2/POMC	2.01755915967535
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	14/933	86/9376	1.63593309903038	JUN/MYC/CBLB/MAPK10/PIK3R1/MAPK3/CAMK2D/PAK3/NCK2/PIK3CA/PIK3CD/STAT5A/GAB1/PIK3CB	1.96938607938623
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	9/933	49/9376	1.84579040619463	GALNT13/ST6GAL2/C1GALT1/ST6GAL1/GALNT15/B4GALT3/C1GALT1C1/C1GALT1C1L/GALNT10	1.97318530156478
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	5/933	21/9376	2.39269126728934	CHST11/CHST7/CHSY3/UST/CSGALNACT1	2.1238344902391
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	4/933	15/9376	2.67981421936406	ST3GAL5/ST6GALNAC6/ST6GALNAC5/HEXB	2.16433172545868
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	22/933	155/9376	1.42635272966152	NR4A1/STAR/LDLR/ADCY1/PBX1/GNAQ/ADCY3/MAPK3/PDE8B/CACNA1C/WNT2/WNT5B/CAMK2D/PLCB3/LEF1/SP1/CDKN2B/FZD3/POMC/WNT5A/KCNA4/ADCY2	1.77919664657685
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	20/933	139/9376	1.4459429241173	HSPA1B/FOS/HSPA1A/JUN/HSP90AA1/ADCY1/MMP2/GNAQ/PIK3R1/ADCY3/MAPK3/PGR/PLCB3/PIK3CA/SP1/HSPA8/PIK3CD/POMC/PIK3CB/ADCY2	1.76075638123618
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	7/933	36/9376	1.95403120161963	GALNT13/C1GALT1/GALNT15/C1GALT1C1/B4GALT5/C1GALT1C1L/GALNT10	1.9064194327091
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	17/933	115/9376	1.48554918682138	FOS/ADCY1/GNG4/GNAQ/PIK3R1/ADCY3/FYN/MAPK3/CACNA1C/CACNA1B/GNG12/CAMK2D/PLCB3/PIK3CA/PIK3CD/PIK3CB/ADCY2	1.74153126121545
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	16/933	107/9376	1.50269956226022	FOXO1/LDHA/PRKAA2/GNAQ/PHKG1/CAMK2D/PPP3R1/PPP3CA/PLCB3/PYGL/EP300/PYGM/PPARGC1A/SIRT1/PCK2/ADCY2	1.73844926309446
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	23/933	166/9376	1.39237335192861	INSR/IRS2/NPR1/EDNRB/ADCY1/GNAQ/ADCY3/MAPK3/CACNA1C/MYLK3/SRF/MYL9/SLC8A1/RGS2/ATP2B3/PPIF/KCNJ8/PPP3R1/PPP3CA/PLCB3/MEF2C/PRKG1/ADCY2	1.6955156349622
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	10/933	59/9376	1.7032717495958	MGST1/GGT5/GPX1/GSTK1/GSTT2B/GPX3/GSTA1/GGT7/LAP3/GSR	1.80131305129146
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	15/933	99/9376	1.52262171554776	FOS/JUN/ADCY1/MMP2/MAPK10/PIK3R1/ADCY3/MAPK3/IGF1R/NOTCH2/PIK3CA/SP1/PIK3CD/PIK3CB/ADCY2	1.73771814367785
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	11/933	67/9376	1.64988562013086	RPS6KA2/ADCY1/GNAQ/MAPK3/CACNA1C/CAMK2D/PPP3R1/PPP3CA/PLCB3/EP300/GRIA1	1.77460164260618
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	12/933	75/9376	1.60788853161844	PC/GLUL/PRPS2/ASS1/SHMT2/BCAT1/BCAT2/ALDOA/RPIA/ENO1/ENO2/CTH	1.75698407457533
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	12/933	75/9376	1.60788853161844	RPRM/SERPINE1/GADD45A/IGFBP3/STEAP3/GADD45B/CCNG2/CHEK2/SHISA5/THBS1/GADD45G/PMAIP1	1.75698407457533
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	33/933	254/9376	1.30561814821379	HGF/FGF7/HTR2A/EDNRB/ADCY1/CD38/PTGER3/FGF10/VEGFC/HRH1/GNAQ/ADCY3/CACNA1C/NTRK1/GNA14/MYLK3/GRIN3A/SLC8A1/GNAL/PHKG1/ATP2B3/FGF2/CACNA1B/PPIF/PLCD1/CAMK2D/PPP3R1/PPP3CA/PLCB3/NGF/AVPR1A/HTR7/ADCY2	1.64145518353419
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	17/933	116/9376	1.4727427283143	CXCL12/ACTB/ACTG1/VCAM1/MMP2/PIK3R1/PTPN11/MYL9/ARHGAP5/VCL/CLDN10/PXN/VAV3/PIK3CA/ICAM1/PIK3CD/PIK3CB	1.70304617802679
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	19/933	133/9376	1.4356147603736	HLA-C/HLA-A/IFNGR2/PIK3R1/FYN/MAPK3/PTPN11/IFNGR1/IFNAR1/PPP3R1/PPP3CA/IFNAR2/VAV3/PIK3CA/HLA-B/ICAM1/PIK3CD/MICB/PIK3CB	1.68189932537868
Organismal Systems	Nervous system	hsa04730	Long-term depression	10/933	60/9376	1.67488388710254	GNAQ/MAPK3/GRIA3/LYN/IGF1R/GRID2/PLA2G4C/PLCB3/GRIA1/PRKG1	1.74328346197742
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	11/933	68/9376	1.6256225963054	RDH10/AOX1/DHRS3/ALDH1A1/ADH5/HSD17B6/RDH11/RDH5/BCO1/CYP3A5/ADH1C	1.72114223046392
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	12/933	76/9376	1.58673210357082	ACTB/ACTG1/ADCY1/GNAQ/ADCY3/MYLK3/SLC4A2/CAMK2D/PLCB3/SLC26A7/CA2/ADCY2	1.70719542787649
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	11/933	69/9376	1.60206284853286	MAPK10/PIK3R1/FYN/MAPK3/LYN/PLA2G4C/VAV3/PIK3CA/PIK3CD/GAB2/PIK3CB	1.66855137380309
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	7/933	38/9376	1.85118745416596	INSR/NEDD4L/PIK3R1/MAPK3/PIK3CA/PIK3CD/PIK3CB	1.74770505665511
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	27/933	205/9376	1.32356677907615	C3/HLA-C/JUN/STAT3/HLA-A/NFKBIA/IL6ST/GSN/MAPKAPK2/PIK3R1/MAPK3/LYN/HLA-F/SRF/HDAC7/NFKB2/PXN/GTF2H2/EP300/PIK3CA/HLA-B/CDKN2B/EGR3/PIK3CD/STAT5A/PMAIP1/PIK3CB	1.55707874013716
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	4/933	17/9376	2.3645419582624	GLUL/CA8/CA2/CA13	1.87186574499929
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	32/933	250/9376	1.28631082529475	HSPA1B/HLA-C/HSPA1A/HLA-A/NEDD4L/PSD3/RAB31/LDLR/CBLB/SH3KBP1/CAV2/ACTR3B/RAB11FIP1/CAV1/TGFBR2/WASHC4/HLA-F/KIF5A/IGF1R/PRKCI/SH3GLB1/EPN3/SNX4/WASHC2A/RAB11FIP3/PLD1/EPN2/HLA-B/HSPA8/SMAD3/RAB11FIP4/TRAF6	1.52526605955161
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	13/933	86/9376	1.51908073481393	ACTB/ACTG1/SGCE/DES/CACNA1C/ITGA1/JUP/ITGA5/PKP2/SLC8A1/SNTB1/LEF1/CACNB2	1.60751244868178
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	28/933	217/9376	1.29668429969229	FOS/JUN/HSP90AA1/FGF7/STAT3/MGST1/KLF4/RPS6KA2/ADCY1/MYC/FGF10/BCL6/PIK3R1/ADCY3/MAPK3/GSTT2B/CACNA1C/GSTA1/EPHX1/FGF2/CACNA1B/PGR/NOTCH2/PIK3CA/PIK3CD/STAT5A/PIK3CB/ADCY2	1.46986844715039
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	11/933	71/9376	1.55693431758827	LDHA/HIF1A/MYC/PIK3R1/MAPK3/NTRK1/HK2/PIK3CA/PIK3CD/PIK3CB/PDK1	1.56586036157328
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	17/933	122/9376	1.40031275806933	INSR/IRS2/FOXO1/PRKAA2/TBC1D1/PIK3R1/EEF2/IGF1R/PPP2R3A/FOXO3/PIK3CA/PPARG/PPARGC1A/PIK3CD/SIRT1/PCK2/PIK3CB	1.47942401640195
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	15/933	105/9376	1.4356147603736	ACTB/ACTG1/ADCY1/SGCE/DES/ADCY3/CACNA1C/ITGA1/ITGA5/TPM2/SLC8A1/SNTB1/TGFB2/CACNB2/ADCY2	1.4921483788099
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	14/933	97/9376	1.4504149125424	FOS/ADCY1/GNG4/GNAQ/ADCY3/MAPK3/GRIA3/CACNA1C/GNG12/CAMK2D/PLCB3/GRIA1/PRKG1/ADCY2	1.48226586064252
NA	NA	hsa04081	Hormone signaling	28/933	219/9376	1.28484243394167	INSR/IRS2/STAT3/NPR1/ADCY1/GNG4/SLC40A1/TRH/GNAQ/PIK3R1/ADCY3/PRLR/GNA14/IGF1R/THPO/GNG12/DIO2/PLCB3/PIK3CA/AVPR1A/PRKG1/PIK3CD/RAMP3/STAT5A/POMC/PRL/PIK3CB/ADCY2	1.41784319742637
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	8/933	48/9376	1.67488388710254	AOX1/AACS/ALDH6A1/BCAT1/BCAT2/HIBADH/OXCT2/BCKDHA	1.55823686548238
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	13/933	89/9376	1.46787576622469	HTR2A/TUBB2B/ADCY1/GNAQ/ADCY3/MAPK3/TUBB2A/TUBA1A/TUBB3/TUBB4A/PLCB3/PRKG1/ADCY2	1.47423221549033
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	13/933	89/9376	1.46787576622469	GABRA2/SLC38A2/GABRE/ADCY1/GNG4/GLUL/ADCY3/GABARAPL1/CACNA1C/HAP1/CACNA1B/GNG12/ADCY2	1.47423221549033
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	16/933	115/9376	1.39816394053777	MAOB/DUSP1/HTR2A/SLC18A2/GNG4/APP/GNAQ/MAPK3/CACNA1C/KCND2/CACNA1B/GNG12/PLA2G4C/PLCB3/CYP4X1/HTR7	1.42810443999434
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	16/933	115/9376	1.39816394053777	EGR1/FOS/JUND/AKAP13/ADCY1/MMP14/GNAQ/ADCY3/MAPK3/GATA3/PLD1/PLCB3/SP1/LRP5/MEF2C/ADCY2	1.42810443999434
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	34/933	275/9376	1.24245931988697	HSPA1B/EGR1/HSPA1A/LAMC1/MT-ND4/MT-ATP6/TUBB2B/NCAM2/CAV2/MAPK10/PIK3R1/FYN/MAPK3/CAV1/CACNA1C/PRNP/IL1B/GRIN3A/KIF5A/MT-ND3/TUBB2A/TUBA1A/CACNA1B/IL6/PPIF/TUBB3/PPP3R1/PPP3CA/TUBB4A/PIK3CA/NCAM1/HSPA8/PIK3CD/PIK3CB	1.35655915854776
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	18/933	133/9376	1.36005608877499	MAOB/FOS/SLC18A2/GNG4/COMT/MAPK10/GNAQ/GRIA3/CACNA1C/KIF5A/GNAL/PPP2R3A/CACNA1B/GNG12/CAMK2D/PPP3CA/PLCB3/GRIA1	1.39016890127821
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	14/933	99/9376	1.42111360117791	FOS/JUN/HIF1A/MAPK10/PIK3R1/MAPK3/PLA2G4C/PLD1/WASF1/PIK3CA/SP1/PIK3CD/DGKI/PIK3CB	1.40020348092385
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	14/933	99/9376	1.42111360117791	ACTB/ACTG1/SGCE/PRKAA2/DES/CACNA1C/ITGA1/ITGA5/TPM2/SLC8A1/SNTB1/IL6/TGFB2/CACNB2	1.40020348092385
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	4/933	19/9376	2.1156428047611	IDUA/HEXB/GNS/SGSH	1.61812370426762
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	18/933	134/9376	1.3499064164707	PLA2G2A/NPR1/ADCY1/CALD1/GNAQ/ADCY3/MAPK3/CACNA1C/MYLK3/MYL9/PLA2G4C/PLCB3/AVPR1A/PPP1R12B/PRKG1/RAMP3/PTGIR/ADCY2	1.35612395964142
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	6/933	34/9376	1.7734064686968	RORA/PRKAA2/BHLHE40/CSNK1E/NR1D2/NR1D1	1.50177680597566
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	15/933	110/9376	1.37035954399298	HSP90AA1/RPS6KA2/ADCY1/MAPK10/PIK3R1/ADCY3/MAPK3/IGF1R/CDC25B/PGR/PIK3CA/CPEB2/PIK3CD/PIK3CB/ADCY2	1.29882847327214
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	8/933	51/9376	1.57636130550827	PLA2G2A/ENPP2/LPCAT4/GDPD3/PLA2G4C/PLD1/PLA2G7/TMEM86A	1.37193504403641
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	28/933	226/9376	1.24504642935056	FOS/JUN/NPR1/NFKBIA/ADCY1/PTGER3/MAPK10/PIK3R1/ADCY3/RRAS/MAPK3/GRIA3/CACNA1C/MYL9/GRIN3A/ATP2B3/CAMK2D/PLD1/PTGER2/EP300/GRIA1/VAV3/PIK3CA/PIK3CD/BDNF/POMC/PIK3CB/ADCY2	1.23956731619486
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	8/933	52/9376	1.54604666501773	TSPO/STAR/LDLR/MYLIP/LIPA/LRP2/LRP1/OSBPL5	1.3125273559529
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	20/933	156/9376	1.2883722208481	STAT3/LDLR/NFKBIA/MYC/TNFRSF1A/SOCS3/PIK3R1/MAPK3/IFNAR1/STAT2/CD81/CLDN10/MX2/IFNAR2/PIK3CA/TLR3/PIK3CD/TRAF6/OAS2/PIK3CB	1.20733648839584
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	7/933	44/9376	1.59875280132515	HLA-C/HLA-A/HLA-DQA2/HSPD1/HLA-F/IL1B/HLA-B	1.32331914889066
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	6/933	36/9376	1.67488388710254	ENPP1/HK2/PYGL/PYGM/GYG1/PGM2L1	1.34860553303738
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	20/933	157/9376	1.28016602835863	INSR/FOS/JUN/IRS2/MAP3K5/TNFRSF1A/PRKAA2/SOCS3/MAPK10/PIK3R1/IL1B/CASP7/XBP1/CXCL8/IL6/IL6R/PIK3CA/PPARG/PIK3CD/PIK3CB	1.17679674304386
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	4/933	21/9376	1.91415301383147	ENPP1/BCAT1/BCAT2/DPYD	1.39407042015145
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	7/933	45/9376	1.5632249612957	HLA-C/HLA-A/HLA-DQA2/HLA-F/IL1B/IL6/HLA-B	1.2589315614571
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/933	14/9376	2.1534221405604	CHST2/B3GNT2/B4GALT3	1.43564164738532
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	6/933	37/9376	1.62961675501868	UAP1/GALK1/HK2/GFPT2/GALK2/TGDS	1.27557211448086
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	14/933	105/9376	1.33990710968203	JUN/CITED2/HIF1A/MITF/OPTN/MAPK10/RRAS/GABARAPL1/MRAS/PHB2/RAB7B/FOXO3/SP1/RPS27A	1.16431280295233
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	9/933	62/9376	1.45876983715382	TLE2/DTX4/HEY2/MAML3/DTX3L/NCSTN/EP300/NOTCH2/TLE3	1.20476030538552
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	10/933	71/9376	1.41539483417116	JUN/NFKBIA/CXCL2/MAPK10/LYN/PTPN11/CXCL8/ATP6V1C1/ATP6V1B2/NOD1	1.16791205836912
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	14/933	106/9376	1.32726647657182	HSP90AA1/FOXO1/NFKBIA/PIK3R1/MAPK3/PLAT/IGF1R/INSRR/LEF1/EP300/PIK3CA/PIK3CD/KLK3/PIK3CB	1.12640002588477
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	9/933	63/9376	1.4356147603736	GADD45A/WNT2/GADD45B/WNT5B/BMP4/LEF1/GADD45G/FZD3/WNT5A	1.15320396161648
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	5/933	30/9376	1.67488388710254	ABCC3/IL1B/SHMT2/IL6/FPGS	1.23070754728969
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	13/933	98/9376	1.33307084891835	NR4A1/NPR1/STAR/LDLR/ADCY1/GNAQ/ADCY3/CACNA1C/ATP2B3/CAMK2D/PLCB3/POMC/ADCY2	1.10179435550843
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	21/933	170/9376	1.24138452808776	JUN/ACTB/YBX3/NEDD4L/ACTG1/MAP3K5/PRKAA2/MAPK10/ACTR3B/TJP2/MAGI1/MYL9/PRKCI/TUBA1A/CD1D/AMOTL2/HCLS1/RAP2C/CLDN10/CGNL1/ARHGEF2	1.05578739027178
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	18/933	144/9376	1.2561629153269	KCND3/RORA/MAP3K5/MAPK10/GNAQ/PIK3R1/GRIA3/RB1CC1/XBP1/GRIN3A/PPIF/PLCB3/GRIA1/PIK3CA/SP1/PIK3CD/TWNK/PIK3CB	1.02974020781646
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	10/933	73/9376	1.37661689350893	MAOB/AOX1/MGST1/GSTK1/ADH5/GSTT2B/GSTA1/CYP3A5/FMO1/ADH1C	1.07381083511525
Human Diseases	Immune disease	hsa05330	Allograft rejection	6/933	39/9376	1.54604666501773	HLA-C/HLA-A/HLA-DQA2/HLA-F/CD40/HLA-B	1.13589045081503
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	27/933	227/9376	1.19529158462824	SOD2/FOS/JUN/HGF/MT-ND4/MGST1/MT-ATP6/NFKBIA/HIF1A/MAP3K5/NFE2L2/MAPK10/PIK3R1/MAPK3/GSTT2B/PTPN11/MT-ND3/GSTA1/EPHX1/PPIF/AKR1C2/AKR1C3/PLD1/FOXO3/PIK3CA/PIK3CD/PIK3CB	0.990119718308958
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	9/933	65/9376	1.39144199851595	TRPC4/GNAQ/PIK3R1/MAPK3/CACNA1C/PLCB3/PIK3CA/PIK3CD/PIK3CB	1.05269849124087
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	9/933	66/9376	1.37035954399298	COMT/HSD17B7/HSD17B11/HSD17B6/AKR1C2/AKR1C3/RDH5/STS/CYP3A5	1.00368800374069
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	5/933	32/9376	1.57020364415863	TNFRSF1A/MAPK10/CASP7/PMAIP1/NGFR	1.0740305340196
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	3/933	16/9376	1.88424437299035	HEXB/B3GALT5/GBGT1	1.17671810942514
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	10/933	75/9376	1.33990710968203	MGST1/MAP3K5/PIK3R1/MAPK3/GSTT2B/GSTA1/PIK3CA/PIK3CD/PMAIP1/PIK3CB	0.982435672797196
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	10/933	75/9376	1.33990710968203	ADCY1/GPX1/GNAQ/ADCY3/LRP2/GPX3/PLCB3/TTR/GSR/ADCY2	0.982435672797196
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	13/933	102/9376	1.28079356072547	PLA2G2A/ADCY1/CD38/GNAQ/ADCY3/CLCA1/SLC4A2/ATP2B3/BST1/PLCB3/RAB3D/CA2/ADCY2	0.947832835337354
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	6/933	41/9376	1.47062975452906	GABRA2/GABRE/GRIA3/GRIN3A/CACNA1B/GRIA1	1.00390406707126
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	6/933	41/9376	1.47062975452906	MYC/TYMP/MMP2/MAPK3/CXCL8/THBS1	1.00390406707126
Human Diseases	Cancer: specific types	hsa05214	Glioma	10/933	76/9376	1.32227675297569	GADD45A/PIK3R1/MAPK3/GADD45B/IGF1R/CAMK2D/PIK3CA/GADD45G/PIK3CD/PIK3CB	0.937718246270398
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	20/933	168/9376	1.19634563364467	HSP90AA1/STAT3/TNFRSF1A/GLUL/IFNGR2/MAPK10/TLR4/TNFAIP3/IL1B/IFNGR1/IFNAR1/STAT2/CASP1/PLA2G4C/CAMK2D/PYGL/IFNAR2/PYGM/TLR3/STAT5A	0.853633202429338
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	13/933	104/9376	1.2561629153269	PLA2G2A/LPCAT3/SAMD8/LPCAT4/PLPP4/AGPAT4/PNPLA7/GPD1L/PLA2G4C/PLD1/SGMS1/DGKI/ETNPPL	0.873221219855784
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	3/933	17/9376	1.7734064686968	GGT5/GGT7/FMO1	1.06095167462488
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	7/933	51/9376	1.37931614231974	ACTB/ACTG1/ADCY3/ERO1A/TJP2/ATP6V1C1/ATP6V1B2	0.902900842654991
Organismal Systems	Endocrine system	hsa04924	Renin secretion	9/933	69/9376	1.31077869425416	NPR1/CTSB/GNAQ/CACNA1C/CLCA1/PPP3R1/PPP3CA/PTGER2/PLCB3	0.861289180207913
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	10/933	78/9376	1.2883722208481	INPP4B/ALDH6A1/PLCD1/IMPA2/PLCB3/PIK3CA/PIK3CD/INPP4A/INPP5K/PIK3CB	0.850127407893221
NA	NA	hsa04082	Neuroactive ligand signaling	23/933	199/9376	1.16147726844297	GABRA2/HTR2A/SLC18A2/GABRE/ADCY1/GNG4/HRH1/GNAQ/ADCY3/GRIA3/P2RY1/GRIN3A/GNAL/GRIK2/GRM8/GNG12/PLCB3/GRIA1/OGFRL1/HTR7/GRM7/POMC/ADCY2	0.765359772819787
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	3/933	18/9376	1.67488388710254	NEU1/HEXB/MANBA	0.952690549261626
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	52/933	480/9376	1.08867452661665	DKK1/MT-ND4/MT-ATP6/TUBB2B/UBE2L6/MAP3K5/TNFRSF1A/GPX1/APP/OPTN/MAPK10/GNAQ/MAPK3/GRIA3/RB1CC1/CACNA1C/PRNP/TANK/WNT2/GPX3/CSNK1E/SNCAIP/IL1B/CASP7/XBP1/HAP1/KIF5A/MT-ND3/TUBB2A/DERL1/TUBA1A/WNT5B/C9orf72/CACNA1B/IL6/PPIF/TUBB3/CAMK2D/PPP3R1/PPP3CA/TUBB4A/PLCB3/MAP3K10/GRIA1/LRP5/NEFH/DNAH14/FZD3/BDNF/CSF1/WNT5A/RPS27A	0.662979615891286
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	12/933	99/9376	1.21809737243821	C3/CFD/C1S/C1R/C2/MASP1/CFI/HLA-DQA2/DEFB1/ICAM1/CFH/CFB	0.725174155415868
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	4/933	28/9376	1.4356147603736	FPGS/AKR1C3/SPR/MOCOS	0.767362048092153
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	42/933	388/9376	1.0878111844068	INSR/IRS2/DKK1/MT-ND4/MT-ATP6/TUBB2B/MAP3K5/TNFRSF1A/APP/MAPK10/GNAQ/PIK3R1/MAPK3/RB1CC1/CACNA1C/WNT2/RTN4/CSNK1E/IL1B/CASP7/XBP1/KIF5A/MT-ND3/TUBB2A/TUBA1A/WNT5B/NCSTN/IL6/LRP1/PPIF/TUBB3/PPP3R1/PPP3CA/TUBB4A/PLCB3/PIK3CA/LRP5/PIK3CD/FZD3/CSF1/WNT5A/PIK3CB	0.587235404493602
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	5/933	37/9376	1.35801396251557	MAOB/AOX1/ADH5/COMT/ADH1C	0.725318415590934
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	17/933	149/9376	1.14656480862053	GABRA2/MT-ND4/GABRE/ADCY1/GNG4/MAPK10/GNAQ/ADCY3/MAPK3/GRIA3/CACNA1C/MT-ND3/CACNA1B/GNG12/PLCB3/GRIA1/ADCY2	0.599474404008177
Organismal Systems	Digestive system	hsa04970	Salivary secretion	11/933	93/9376	1.18862727471793	CST3/ADCY1/CD38/GNAQ/ADCY3/SLC4A2/ATP2B3/BST1/PLCB3/PRKG1/ADCY2	0.607686872442923
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	7/933	56/9376	1.2561629153269	ST6GAL2/MAN1C1/MGAT4A/ALG13/ST6GAL1/B4GALT3/MGAT5	0.639117015270873
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	6/933	47/9376	1.28288978586577	PC/LDHA/ADH5/PCK2/ADH1C/ME3	0.646288926497023
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	6/933	48/9376	1.2561629153269	PIK3R1/HK2/PLCB3/PIK3CA/PIK3CD/PIK3CB	0.591453590551015
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	5/933	39/9376	1.2883722208481	AHCY/MTHFD2/ALDH1L2/SHMT2/CTH	0.599874100377577
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	8/933	67/9376	1.19991681464062	LDHA/ADH5/ALDOA/HK2/ENO1/ENO2/PCK2/ADH1C	0.54590022714214
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	6/933	49/9376	1.23052693746309	MAOB/FOSB/JUN/SLC18A2/GRIN3A/BDNF	0.537807429932274
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	4/933	31/9376	1.29668429969229	H6PD/PRPS2/ALDOA/RPIA	0.550001436621798
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	6/933	50/9376	1.20591639871383	CXCL12/IL15/IL15RA/HLA-DQA2/IL6/CD40	0.485295535774181
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	8/933	70/9376	1.14849180829888	MGST1/GSTK1/GSTT2B/GSTA1/EPHX1/AKR1C2/CYP3A5/SULT1A1	0.414522450966729
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	3/933	23/9376	1.31077869425416	ENPEP/CTSA/NLN	0.496041205110259
Organismal Systems	Digestive system	hsa04978	Mineral absorption	7/933	61/9376	1.15319874193945	SLC40A1/CYBRD1/STEAP1/SLC8A1/ATP2B3/ATOX1/MT1A	0.399031106285482
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	5/933	42/9376	1.19634563364467	SLC40A1/PCBP2/LPCAT3/PRNP/STEAP3	0.423926006723662
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	8/933	72/9376	1.11658925806836	NFKBIA/RNF125/MAPK10/TANK/NFKBIB/CXCL8/AZI2/TRAF6	0.330117084895343
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	7/933	63/9376	1.11658925806836	AASS/SETD7/GCDH/PRDM2/SMYD3/PLOD2/PRDM6	0.308647012261579
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	7/933	63/9376	1.11658925806836	PLA2G2A/GGT5/PTGIS/PLA2G4C/AKR1C3/HPGD/CYP2U1	0.308647012261579
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	9/933	83/9376	1.0896834928137	IFI16/GSDME/NFKBIA/NFKBIB/IL1B/CASP7/GSDMD/IL6/CASP1	0.272804579855363
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	5/933	44/9376	1.14196628666082	MAN1C1/MGAT4A/ALG13/HEXB/B4GALT3	0.313763384854953
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	6/933	54/9376	1.11658925806836	AHCY/LDHA/ADI1/BCAT1/BCAT2/CTH	0.28561363378061
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	6/933	54/9376	1.11658925806836	HLA-C/HLA-A/HLA-DQA2/HLA-F/CD40/HLA-B	0.28561363378061
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	5/933	45/9376	1.11658925806836	ABCC3/TAP1/ABCB1/DEFB1/ABCD2	0.260602613157376
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	5/933	46/9376	1.09231557854513	PSMB9/PSME1/PSME4/PSME2/PSMB8	0.208636916323169
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	12/933	116/9376	1.03958310233951	PC/H6PD/PRPS2/ADH5/ALDH6A1/SHMT2/ALDOA/RPIA/HK2/ENO1/ENO2/ME3	0.142597330675216
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	31/933	308/9376	1.01145585389958	SOD2/TGM2/MT-ND4/MT-ATP6/TUBB2B/MAP3K5/GPX1/MAPK10/GNAQ/GRIA3/RB1CC1/GPX3/HAP1/KIF5A/MT-ND3/TUBB2A/TUBA1A/TAF4B/CACNA1B/PPIF/TUBB3/TUBB4A/PLCB3/EP300/MAP3K10/GRIA1/SP1/PPARG/PPARGC1A/DNAH14/BDNF	0.0679555816790893
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/933	17/9376	1.1822709791312	TXNRD1/CTH	0.250037604250472
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/933	17/9376	1.1822709791312	CLEC4M/PCDH7	0.250037604250472
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	10/933	98/9376	1.02543911455257	INPP4B/PIK3R1/PLCD1/IMPA2/PLCB3/PIK3CA/PIK3CD/INPP4A/DGKI/PIK3CB	0.0841522844589417
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	8/933	78/9376	1.03069777667848	PABPC1/HSPD1/EXOSC5/PNPT1/DCP1B/ENO1/ENO2/BTG2	0.0904976950935602
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	8/933	79/9376	1.01765096937876	MGST1/GSTK1/ADH5/GSTT2B/GSTA1/EPHX1/CYP3A5/ADH1C	0.0523707456180866
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	3/933	28/9376	1.0767110702802	ELOVL3/PPT1/HACD1	0.135131242915349
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	3/933	28/9376	1.0767110702802	B3GNT2/B3GALT5/B4GALT3	0.135131242915349
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	3/933	28/9376	1.0767110702802	ATP6V1C1/ATP6V1B2/CA2	0.135131242915349
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	6/933	59/9376	1.02196304975748	ENPP1/TYMP/DPYD/NT5E/UPP1/AK9	0.0562546813476448
Organismal Systems	Digestive system	hsa04976	Bile secretion	9/933	90/9376	1.00493033226152	LDLR/ADCY1/ABCC3/ADCY3/SLC4A2/EPHX1/ABCB1/CA2/ADCY2	0.0156228825714661
Human Diseases	Substance dependence	hsa05032	Morphine addiction	9/933	91/9376	0.99388714179711	GABRA2/GABRE/ADCY1/GNG4/ADCY3/PDE8B/CACNA1B/GNG12/ADCY2	-0.0194783483889232
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	17/933	174/9376	0.981828485542866	HSPA1B/HSPA1A/HSP90AA1/PPP1R15A/DNAJB1/HSPH1/MAP3K5/NFE2L2/MAPK10/ERO1A/CRYAB/DNAJA1/MAN1C1/XBP1/DERL1/HSPA8/DERL3	-0.0804271536403829
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	8/933	82/9376	0.980419836352704	MGST1/IMPDH2/TYMP/GSTT2B/GSTA1/TPMT/DPYD/UPP1	-0.0591970377283538
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/933	20/9376	1.00493033226152	LIPA/HSD17B7	0.00733709503920628
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/933	20/9376	1.00493033226152	UAP1/TGDS	0.00733709503920628
NA	NA	hsa04981	Folate transport and metabolism	3/933	31/9376	0.972513224769215	ABCC3/SHMT2/FPGS	-0.050955732678514
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	3/933	32/9376	0.942122186495177	LDHA/ALDH6A1/BCKDHA	-0.109018136911764
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	12/933	128/9376	0.942122186495177	NPR1/IMPDH2/ENPP1/ADCY1/FHIT/PRPS2/ADCY3/PDE8B/NTPCR/NT5E/AK9/ADCY2	-0.219165028254505
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	4/933	43/9376	0.934818913731648	ADH5/GCDH/CYP2U1/ADH1C	-0.142404349465739
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	8/933	86/9376	0.934818913731648	ADCY1/GNAQ/ADCY3/CACNA1C/PCLO/CAMK2D/PLCB3/ADCY2	-0.201855704840473
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	7/933	76/9376	0.925593727082981	FABP5/SLC27A6/SORBS1/DBI/PPARG/PCK2/ME3	-0.216497526138746
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/933	10/9376	1.00493033226152	ETHE1	0.00518533926607337
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	3/933	33/9376	0.913573029328656	BCAT1/BCAT2/BCKDHA	-0.165325997562531
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/933	22/9376	0.913573029328656	MAOB/HNMT	-0.134908717583979
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	19/933	205/9376	0.931398844535069	INSR/MT-ND4/MT-ATP6/MMP2/MAPK10/PIK3R1/TGFBR2/MT-ND3/PPIF/CAMK2D/PLCB3/TGFB2/GFPT2/PIK3CA/SP1/GSR/SMAD3/PIK3CD/PIK3CB	-0.330124745897195
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	5/933	56/9376	0.897259225233502	GAS1/BOC/LRP2/CSNK1E/CSNK1G3	-0.256334439478037
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/933	23/9376	0.873852462836106	GLUL/ASS1	-0.201347059864068
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/933	23/9376	0.873852462836106	B4GALT3/B3GALNT2	-0.201347059864068
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	2/933	23/9376	0.873852462836106	POLD4/RPA4	-0.201347059864068
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/933	23/9376	0.873852462836106	PCK2/CA2	-0.201347059864068
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	9/933	103/9376	0.878094465082883	SLC38A2/COL6A2/COL6A1/COL21A1/SLC8A1/COL28A1/SLC7A7/COL4A4/COL11A1	-0.413532809882791
NA	NA	hsa03272	Virion - Hepatitis viruses	4/933	48/9376	0.837441943551268	LDLR/HSPG2/CD81/CLDN10	-0.375329684380351
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	3/933	37/9376	0.814808377509342	GLUL/ASS1/GFPT2	-0.375188982188918
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	7/933	83/9376	0.847531605521766	PCGF5/PHC2/AUTS2/SFMBT2/EP300/L3MBTL3/CBX7	-0.463787426112638
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/933	26/9376	0.773023332508863	PLA2G2A/PLA2G4C	-0.385247784045769
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	6/933	73/9376	0.82597013610536	MAP1A/ELL2/SERINC3/MX2/EP300/MAP1B	-0.49619429373596
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	29/933	323/9376	0.902259431442233	PIM1/MCL1/IRS2/VIM/STAT3/TIMP3/MYC/CD44/TNXB/PIK3R1/MAPK3/ITGA5/TNC/ABCB1/FOXP1/MARCKS/CDC25B/THBS1/TGFB2/EP300/NOTCH2/PIK3CA/BMPR2/PIK3CD/SIRT1/FZD3/SPRY2/PIK3CB/ZFPM2	-0.594234588925956
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	7/933	85/9376	0.827589685391842	IMPDH2/ENPP1/TYMP/NTPCR/NT5E/UPP1/AK9	-0.530786101676666
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/933	27/9376	0.744392838712238	AACS/OXCT2	-0.442130407800005
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	2/933	27/9376	0.744392838712238	ELOVL3/HACD1	-0.442130407800005
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	12/933	142/9376	0.849236900502695	NEDD4L/UBE2L6/CBLB/SOCS3/UBE2B/MID1/CUL4B/KLHL9/UBR5/CUL2/RPS27A/TRAF6	-0.601758675160611
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	13/933	154/9376	0.848317812948038	DHRS3/MTHFD2/SHMT2/HSD17B6/BCAT1/CPOX/RFK/RDH11/BCAT2/FPGS/BCO1/SPR/AK9	-0.63089988594146
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	13/933	154/9376	0.848317812948038	ADCY1/GNAQ/ADCY3/MAPK3/CACNA1C/TPM2/SLC8A1/PPP2R3A/ATP2B3/CAMK2D/PLCB3/CACNB2/ADCY2	-0.63089988594146
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/933	53/9376	0.758437986612469	GNAQ/SLC8A1/ATP2B3/PLCB3	-0.58622832540038
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	3/933	41/9376	0.735314877264528	MAOB/SHMT2/CTH	-0.564601937404684
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/933	15/9376	0.669953554841015	NTPCR	-0.42524344888739
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/933	42/9376	0.717807380186801	MAOB/AOX1/GCDH	-0.609276550864343
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	6/933	79/9376	0.763238227034067	SLC18A2/CACNA1B/ATP6V1C1/STXBP1/STX3/ATP6V1B2	-0.702476465627388
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/933	16/9376	0.628081457663451	MAOB	-0.494934768449119
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	2/933	30/9376	0.669953554841015	PC/PCK2	-0.601867460130341
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	2/933	30/9376	0.669953554841015	PIGN/PIGU	-0.601867460130341
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/933	30/9376	0.669953554841015	PLA2G2A/PLA2G4C	-0.601867460130341
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	11/933	138/9376	0.80103142426643	RPS6KA2/ADCY1/ADCY3/MAPK3/IGF1R/CAMK2D/PPP3R1/PGR/PPP3CA/CPEB2/ADCY2	-0.782732057034622
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	16/933	195/9376	0.824558221342787	C3/ACTB/ACTG1/PIK3R1/TLR4/MAPK3/HDAC7/CASP4/GSDMD/ELANE/CASP1/PPIF/PLCB3/PIK3CA/PIK3CD/PIK3CB	-0.822968853631306
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/933	31/9376	0.648342149846143	ALDH6A1/DPYD	-0.651912901978826
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	2/933	31/9376	0.648342149846143	GLUL/SHMT2	-0.651912901978826
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/933	17/9376	0.591135489565601	HSD3B7	-0.56087646612394
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	2/933	32/9376	0.628081457663451	GALK1/HK2	-0.700542472377444
Human Diseases	Immune disease	hsa05310	Asthma	2/933	32/9376	0.628081457663451	HLA-DQA2/CD40	-0.700542472377444
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/933	18/9376	0.558294629034179	LMBRD1	-0.623527306725141
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	2/933	33/9376	0.609048686219104	STX3/VAMP5	-0.747850068643436
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	22/933	268/9376	0.824942810065428	MAOB/DUSP1/MT-ND4/SLC18A2/MT-ATP6/TUBB2B/UBE2L6/MAP3K5/NFE2L2/MAPK10/SNCAIP/XBP1/KIF5A/GNAL/MT-ND3/TUBB2A/TUBA1A/PPIF/TUBB3/CAMK2D/TUBB4A/RPS27A	-0.966526807878533
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	31/933	368/9376	0.846544573372478	ACTB/MT-ND4/ACTG1/MT-ATP6/TUBB2B/MAP3K5/TNFRSF1A/GPX1/OPTN/RB1CC1/TANK/PFN1/GPX3/XBP1/HAP1/KIF5A/MT-ND3/ANG/TUBB2A/DERL1/TUBA1A/C9orf72/CASP1/TUBB3/PPP3R1/PPP3CA/TUBB4A/GRIA1/NUP35/NEFH/DNAH14	-0.998320609759433
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/933	19/9376	0.528910701190275	BCKDHA	-0.683265968263076
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/933	35/9376	0.574245904149441	ALDOA/HK2	-0.838830544706283
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	4/933	63/9376	0.63805100461049	POLD4/CUL4B/RPA4/GTF2H2	-0.958188411770771
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	2/933	36/9376	0.558294629034179	POLD4/RPA4	-0.882650065649489
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	4/933	65/9376	0.61841866600709	PLPP4/AGPAT4/ABHD16A/DGKI	-1.02618036925755
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	2/933	38/9376	0.528910701190275	TAP1/CD40	-0.967266547029413
NA	NA	hsa04382	Cornified envelope formation	16/933	217/9376	0.740962456967021	S100A3/S100A4/LAMA3/S100A6/PLEC/S100A16/UGCG/JUP/PKP2/PPP2R3A/ABHD5/CLDN10/PPL/COL4A4/S100A1/S100A2	-1.28335443273016
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	2/933	41/9376	0.490209918176352	POLD4/RPA4	-1.08743727223
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	11/933	158/9376	0.699635041447895	GADD45A/MYC/CDC7/GADD45B/CHEK2/CDC25B/TGFB2/EP300/GADD45G/SMAD3/CDKN2B	-1.26571964935406
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	3/933	57/9376	0.528910701190275	ELOVL3/PPT1/HACD1	-1.1858617917281
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/933	26/9376	0.386511666254432	LMBRD1	-1.04127452273323
Organismal Systems	Sensory system	hsa04742	Taste transduction	5/933	86/9376	0.58426182108228	GABRA2/CACNA1C/P2RY1/PLCB3/TAS2R1	-1.28747659695383
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	17/933	235/9376	0.726970878657271	ACTB/MT-ND4/NPR1/ACTG1/RPS6KA2/MT-ATP6/ADCY1/MAP3K5/PRKAA2/RPS6/ADCY3/MT-ND3/PPARG/PPARGC1A/PRKG1/DPF3/ADCY2	-1.40904256785148
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	2/933	44/9376	0.456786514664328	TAF4B/GTF2H2	-1.2005702611986
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	2/933	44/9376	0.456786514664328	POLD4/TDG	-1.2005702611986
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	2/933	44/9376	0.456786514664328	AQP3/ADCY3	-1.2005702611986
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	28/933	370/9376	0.760487819008719	C3/GABRA2/GAL/HTR2A/TSPO/EDNRB/NPW/GABRE/PTGER3/TRH/HRH1/PRLR/GRIA3/P2RY1/GRIN3A/GRIK2/GRID2/GRM8/PTGER2/GRIA1/AVPR1A/OGFRL1/F2RL2/HTR7/PTGIR/GRM7/POMC/PRL	-1.56257388445389
Cellular Processes	Cell motility	hsa04814	Motor proteins	13/933	194/9376	0.673406923680401	ACTB/ACTG1/TUBB2B/MYL9/TPM2/KIF5A/KIF26B/TUBB2A/TUBA1A/TUBB3/TUBB4A/DNAH14/MYO1E	-1.52797855765634
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/933	32/9376	0.314040728831726	GABARAPL1	-1.29206680784312
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	2/933	50/9376	0.401972132904609	MAOB/LAP3	-1.40940816750241
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	4/933	83/9376	0.484303774583866	SOD2/GSTK1/NUDT7/ABCD2	-1.56867543506464
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	2/933	54/9376	0.372196419356119	RPA4/FANCE	-1.53795696909784
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/933	36/9376	0.279147314517089	FGGY	-1.44046396532121
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	4/933	87/9376	0.462036934373114	CACNA1C/TPM2/SLC8A1/CACNB2	-1.67573627140353
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/933	43/9376	0.233704728432912	PLA2G2A	-1.67416325645323
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	7/933	143/9376	0.491923938869276	C3/C1S/C1R/C2/HLA-DQA2/ELANE/CD40	-2.03518268583742
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/933	46/9376	0.218463115709026	CPOX	-1.76630475701961
Human Diseases	Substance dependence	hsa05034	Alcoholism	9/933	191/9376	0.473527381693911	MAOB/FOSB/SLC18A2/GNG4/MAPK3/GRIN3A/HDAC7/GNG12/BDNF	-2.44360473114886
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	4/933	117/9376	0.343565925559495	ACTB/ACTG1/DPF3/CECR2	-2.37508999799461
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	3/933	103/9376	0.292698155027628	PABPC1/EIF4A3/PPP2R3A	-2.39933748361444
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	5/933	138/9376	0.364105192848378	MT-ND4/MT-ATP6/MT-ND3/ATP6V1C1/ATP6V1B2	-2.50157718938452
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	3/933	108/9376	0.279147314517089	EIF4A3/NUP35/IPO4	-2.50462926856228
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	4/933	183/9376	0.219656903226562	EMG1/WDR75/TBL3/EFL1	-3.54372957441355
Genetic Information Processing	Transcription	hsa03040	Spliceosome	5/933	243/9376	0.206775788531177	HSPA1B/HSPA1A/EIF4A3/HNRNPU/HSPA8	-4.16457257714506
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	6/933	449/9376	0.134289131259892	ADCY3/SLC8A1/GNAL/RGS2/CAMK2D/PRKG1	-6.24915560116845