category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	5/23	142/9376	14.3539497856705	FOS/FOSB/SOCS3/JUND/JUNB	7.95120709203139
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	4/23	94/9376	17.3469010175763	FOS/FOSB/JUND/HSP90AA1	7.89864630165987
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	4/23	139/9376	11.7309978104473	FOS/HSPA1A/HSPA1B/HSP90AA1	6.32056822629246
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	4/23	174/9376	9.37131434282858	HSPA1A/HSPA1B/HSP90AA1/DNAJB1	5.52714997134861
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	3/23	82/9376	14.9141039236479	HSPA1A/HSPA1B/HSP90AA1	6.27530623017454
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	4/23	216/9376	7.54911433172303	FOS/HSPA1A/HSPA1B/HSP90AA1	4.82876199535417
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	3/23	112/9376	10.9192546583851	HSPA1A/HSPA1B/LAMA3	5.23676237044652
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	3/23	119/9376	10.276945560833	FOS/SOCS3/JUNB	5.05030312710983
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	3/23	122/9376	10.024233784747	FOS/SOCS3/JUNB	4.97507456887865
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	4/23	275/9376	5.92948616600791	HSPA1A/HSPA1B/NDUFA4L2/CAV2	4.11431492287805
Human Diseases	Infectious disease: viral	hsa05162	Measles	3/23	136/9376	8.9923273657289	FOS/HSPA1A/HSPA1B	4.6556553405905
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	3/23	142/9376	8.61236987140233	FOS/HSP90AA1/CAV2	4.53255630582117
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	4/23	300/9376	5.43536231884058	FOS/HSPA1A/HSPA1B/JUND	3.87183262827432
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	3/23	157/9376	7.78953198559956	FOS/SOCS3/NDUFA4L2	4.25423862566823
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	2/23	56/9376	14.5590062111801	HSPA1A/HSPA1B	5.04647360466904
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	2/23	62/9376	13.1500701262272	HSPA1A/HSPA1B	4.75971119171834
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	2/23	69/9376	11.8160050409578	FOS/FOSB	4.4715764317061
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	2/23	71/9376	11.4831598285364	FOS/SOCS3	4.39680577892716
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	2/23	78/9376	10.4526198439242	FOS/SERPING1	4.15698839101523
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	2/23	88/9376	9.26482213438735	SERPING1/A2M	3.86267201715498
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	3/23	248/9376	4.9312762973352	FOS/HSP90AA1/ANXA2	3.11132717093655
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	3/23	250/9376	4.89182608695652	HSPA1A/HSPA1B/CAV2	3.09283880702279
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	2/23	109/9376	7.47985640207419	FOS/HSP90AA1	3.37429569786318
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	2/23	115/9376	7.08960302457467	FOS/JUND	3.25823983796641
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	2/23	142/9376	5.74157991426822	SOCS3/UBE2B	2.82323091271606
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	2/23	173/9376	4.71274189494848	SOCS3/DNAJB1	2.44414624498029
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	2/23	196/9376	4.15971606033718	FOS/ZFP36	2.21681188794545
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	2/23	203/9376	4.01627757549797	LAMA3/CAV2	2.15445643448132
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	2/23	204/9376	3.99658994032396	PLCE1/CAV2	2.14577641236005
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/23	38/9376	10.7276887871854	NNMT	2.97953588627548
NA	NA	hsa04382	Cornified envelope formation	2/23	217/9376	3.75716289320777	LAMA3/S100A6	2.03770988125155
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	2/23	217/9376	3.75716289320777	FOS/HSP90AA1	2.03770988125155
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	2/23	224/9376	3.63975155279503	FOS/ZFP36	1.98291065534337
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	2/23	226/9376	3.60754136206233	FOS/PLCE1	1.96765506449633
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	2/23	227/9376	3.59164910936602	FOS/NDUFA4L2	1.96009176773751
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/23	47/9376	8.67345050878816	SOCS3	2.61514737250267
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/23	49/9376	8.31943212067435	FOSB	2.54729080678071
Genetic Information Processing	Transcription	hsa03040	Spliceosome	2/23	243/9376	3.35516192521023	HSPA1A/HSPA1B	1.84455355323815
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	1/23	70/9376	5.82360248447205	SOCS3	2.00869082155502
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/23	72/9376	5.66183574879227	RNF125	1.96907588867567
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/23	78/9376	5.2263099219621	PLCE1	1.85860867912947
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	1/23	78/9376	5.2263099219621	CAV2	1.85860867912947
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	1/23	78/9376	5.2263099219621	FOS	1.85860867912947
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	1/23	87/9376	4.68565717141429	TPM1	1.71263245547239
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	1/23	87/9376	4.68565717141429	FOS	1.71263245547239
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	1/23	89/9376	4.58036150464094	LAMA3	1.6828997604768
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	1/23	90/9376	4.52946859903382	FOS	1.66836214242637
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	1/23	91/9376	4.47969421882465	FOS	1.65403582884323
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	1/23	93/9376	4.3833567087424	FOS	1.62599488900446
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	1/23	93/9376	4.3833567087424	LAMA3	1.62599488900446
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	1/23	95/9376	4.29107551487414	FOS	1.59873452150672
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	1/23	97/9376	4.2025997310623	FOS	1.5722153483561
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	1/23	98/9376	4.15971606033718	PLCE1	1.5592221671057
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	1/23	99/9376	4.11769872639438	FOS	1.54640075691803
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	1/23	99/9376	4.11769872639438	FOS	1.54640075691803
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	1/23	99/9376	4.11769872639438	TPM1	1.54640075691803
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	1/23	101/9376	4.03616013775291	PLCE1	1.52125665391274
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	2/23	362/9376	2.25222195532068	LAMA3/HSP90AA1	1.2048997422481
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	1/23	103/9376	3.95778809624314	FOS	1.49675124570024
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	1/23	103/9376	3.95778809624314	LAMA3	1.49675124570024
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	1/23	105/9376	3.8824016563147	TPM1	1.47285484159376
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	1/23	106/9376	3.84577522559475	HSP90AA1	1.46112626896624
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	1/23	109/9376	3.7399282010371	FOS	1.42677975676345
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	1/23	109/9376	3.7399282010371	SOCS3	1.42677975676345
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	1/23	110/9376	3.70592885375494	HSP90AA1	1.4156003368476
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	1/23	115/9376	3.54480151228733	FOS	1.36159510457266
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	1/23	122/9376	3.34141126158232	FOS	1.29082378633334
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	1/23	122/9376	3.34141126158232	PLCE1	1.29082378633334
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	1/23	130/9376	3.13578595317726	FOS	1.2159803209823
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	1/23	133/9376	3.06505393919582	FOS	1.18939150664688
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	1/23	137/9376	2.97556331323389	FOS	1.15508206779898
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	1/23	138/9376	2.95400126023945	NDUFA4L2	1.14669915575602
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	1/23	138/9376	2.95400126023945	SOCS3	1.14669915575602
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	1/23	138/9376	2.95400126023945	FOS	1.14669915575602
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	1/23	148/9376	2.75440658049354	FOS	1.06679605609243
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	1/23	149/9376	2.73592063028888	NDUFA4L2	1.05917281964849
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	1/23	154/9376	2.64709203839639	TPM1	1.02197379144598
NA	NA	hsa04518	Integrin signaling	1/23	154/9376	2.64709203839639	LAMA3	1.02197379144598
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	1/23	154/9376	2.64709203839639	FOS	1.02197379144598
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	1/23	156/9376	2.61315496098105	SOCS3	1.00750454912469
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	1/23	163/9376	2.50093358228861	FOS	0.958581030423052
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	1/23	168/9376	2.42650103519669	HSP90AA1	0.925162808311992
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	1/23	168/9376	2.42650103519669	SOCS3	0.925162808311992
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	1/23	180/9376	2.26473429951691	SOCS3	0.84959149671481
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	1/23	187/9376	2.17995814926761	HSP90AA1	0.808215863753787
Human Diseases	Substance dependence	hsa05034	Alcoholism	1/23	191/9376	2.13430457546096	FOSB	0.785381878289361
Cellular Processes	Cell motility	hsa04814	Motor proteins	1/23	194/9376	2.10129986553115	TPM1	0.768620380647449
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	1/23	200/9376	2.03826086956522	FOS	0.735984843623075
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	1/23	205/9376	1.98854718981972	NDUFA4L2	0.709643254098021
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	1/23	212/9376	1.92288761279737	PLCE1	0.673981996988021
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	1/23	214/9376	1.90491670052824	FOS	0.664040297275343
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	1/23	233/9376	1.74958014554954	TPM1	0.574547268601635
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	1/23	235/9376	1.73469010175763	NDUFA4L2	0.565607753789733
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	1/23	238/9376	1.71282426013884	PLCE1	0.552356491911
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	1/23	238/9376	1.71282426013884	FOS	0.552356491911
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	1/23	253/9376	1.61127341467606	PLCE1	0.488766036801596
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	1/23	254/9376	1.60492981855529	PLCE1	0.484675320238872
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	1/23	268/9376	1.52109020116807	NDUFA4L2	0.429183366110847
NA	NA	hsa04517	IgSF CAM signaling	1/23	299/9376	1.36338519703359	PMP22	0.316669143379999
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	1/23	308/9376	1.32354601919819	NDUFA4L2	0.286305540430905
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	1/23	323/9376	1.26208103378651	TPM1	0.237692064726324
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	1/23	333/9376	1.22418070244157	LAMA3	0.206556167037616
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	1/23	368/9376	1.10775047258979	NDUFA4L2	0.104569009246736
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	1/23	388/9376	1.05064993276558	NDUFA4L2	0.0505286032328537
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	1/23	480/9376	0.84927536231884	NDUFA4L2	-0.168105363146276